FB2022_02, released March 29, 2022

Gene: Dmel\l(2)37Cb

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General Information
Symbol
Dmel\l(2)37Cb
Species
D. melanogaster
Name
lethal (2) 37Cb
Annotation Symbol
CG10689
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086444
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
RNA helicase (3.6.4.13)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(2)E104, Cb

Key Links
Genomic Location
Cytogenetic map
37C5-37C5
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:19123998..19126976
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000433338
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA helicase activity
inferred from sequence or structural similarity with SGD:S000000815
(Lasko, 2000)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred from sequence or structural similarity with SGD:S000005294
(Mount and Salz, 2000)
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of spliceosomal complex
inferred from sequence or structural similarity with SGD:S000005294
(Mount and Salz, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.4.13)
Summaries
Gene Group (FlyBase)
SPLICEOSOME COMPLEX C -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
DEAH-BOX RNA HELICASES -
DEAH-box RNA helicases belong to helicase superfamily 2 (SF2). They are characterized by the presence of nine conserved helicase motifs, including the DEAH sequence in motif II. (Adapted from PMID:21509200.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\l(2)37Cb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VIZ3)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
l(2)37Cb-RA
FBtr0081163
NM_136102
2791
894
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
l(2)37Cb-PA
FBpp0080706
102.8
894
6.49
NP_609946
AAF53766
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)37Cb using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
garland cell primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
antennal primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
garland cell primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\l(2)37Cb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of l(2)37Cb
Transgenic constructs containing regulatory region of l(2)37Cb
Aberrations (Deficiencies and Duplications) ( 25 )
Inferred from experimentation ( 25 )
Gene disrupted in
Df(2L)E71
(Wright et al., 1981)
Df(2L)Exel6042
(Ryder, 2004.4.26)
Df(2L)Exel8040
(Ryder, 2004.4.26)
Df(2L)hk-UC2
(Wright, 1996, Stathakis et al., 1995)
Df(2L)NST
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)
Df(2L)TW50
(Wright et al., 1976)
Df(2L)TW130
(Wright, 1996, Stathakis et al., 1995, Gilbert et al., 1984, Wright et al., 1981, Wright et al., 1976)
Df(2L)VA17
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)
Df(2L)VA21
(Wright, 1996, Stathakis et al., 1995)
Df(2L)VA23
(Stathakis et al., 1995)
Gene not disrupted in
Df(2L)E55
(Stathakis et al., 1995)
Df(2L)hk18
(Wright, 1996, Pentz et al., 1986, Gilbert et al., 1984)
Df(2L)hk-UC1
(Wright, 1996, Stathakis et al., 1995)
Df(2L)OD15
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)
Df(2L)Sd37
(Wright, 1996, Stathakis et al., 1995)
Df(2L)Sd57
(Wright, 1996, Stathakis et al., 1995)
Df(2L)Sd77
(Wright, 1996, Stathakis et al., 1995)
Df(2L)TE37C-1
(Wright, 1996, Wright et al., 1981)
Df(2L)TE37C-7
(Wright, 1996, Stathakis et al., 1995)
Df(2L)TW137
(Stathakis et al., 1995)
Df(2L)TW203
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)
Df(2L)VA12
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Wright et al., 1981)
Df(2L)VA13
(Wright, 1996, Wright et al., 1981)
Df(2L)VA18
(Stathakis et al., 1995, Pentz et al., 1986)
Df(2L)VA19
(Wright, 1996, Stathakis et al., 1995)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DHX16
14 of 15
Yes
Yes
Hsap\DHX8
4 of 15
No
No
Hsap\DHX15
4 of 15
No
No
Hsap\DHX38
4 of 15
No
No
Hsap\DHX32
3 of 15
No
No
Hsap\DHX33
3 of 15
No
No
Hsap\DHX35
3 of 15
No
No
Hsap\DHX40
3 of 15
No
Yes
Hsap\DQX1
3 of 15
No
No
Hsap\DHX37
2 of 15
No
No
Hsap\DHX9
1 of 15
No
No
Hsap\DHX29
1 of 15
No
No
Hsap\DHX30
1 of 15
No
No
Hsap\DHX34
1 of 15
No
No
Hsap\DHX36
1 of 15
No
No
Hsap\DHX57
1 of 15
No
No
Hsap\TDRD9
1 of 15
No
No
Hsap\YTHDC2
1 of 15
No
No
Hsap\ZCCHC17
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dhx16
14 of 15
Yes
Yes
Mmus\Dhx8
4 of 15
No
No
Mmus\Dhx15
4 of 15
No
No
Mmus\Dhx38
4 of 15
No
No
Mmus\Dhx32
3 of 15
No
No
Mmus\Dhx33
3 of 15
No
No
Mmus\Dhx40
3 of 15
No
Yes
Mmus\Dqx1
3 of 15
No
No
Mmus\Dhx35
2 of 15
No
No
Mmus\Dhx37
2 of 15
No
No
Mmus\Dhx9
1 of 15
No
No
Mmus\Dhx29
1 of 15
No
No
Mmus\Dhx30
1 of 15
No
No
Mmus\Dhx34
1 of 15
No
No
Mmus\Dhx36
1 of 15
No
No
Mmus\Dhx57
1 of 15
No
No
Mmus\Tdrd9
1 of 15
No
No
Mmus\Ythdc2
1 of 15
No
No
Mmus\Zcchc17
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (19)
Rnor\Dhx16
11 of 13
Yes
Yes
Rnor\Dhx15
4 of 13
No
No
Rnor\Dhx38
4 of 13
No
No
Rnor\Dhx8
3 of 13
No
No
Rnor\Dhx32
3 of 13
No
No
Rnor\Dhx33
3 of 13
No
No
Rnor\Dhx35
3 of 13
No
No
Rnor\Dhx40
3 of 13
No
Yes
Rnor\Dqx1
3 of 13
No
No
Rnor\Dhx37
2 of 13
No
No
Rnor\LOC103692182
2 of 13
No
Yes
Rnor\Dhx9
1 of 13
No
No
Rnor\Dhx29
1 of 13
No
No
Rnor\Dhx30
1 of 13
No
No
Rnor\Dhx34
1 of 13
No
No
Rnor\Dhx36
1 of 13
No
No
Rnor\LOC100910750
1 of 13
No
Yes
Rnor\Ythdc2
1 of 13
No
No
Rnor\Zcchc17
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (18)
Xtro\dhx16
8 of 12
Yes
Yes
Xtro\dhx8
3 of 12
No
No
Xtro\dhx15
3 of 12
No
No
Xtro\dhx33
3 of 12
No
No
Xtro\dhx35
3 of 12
No
No
Xtro\dhx38
3 of 12
No
No
Xtro\dhx40
3 of 12
No
Yes
Xtro\dhx32
2 of 12
No
No
Xtro\dhx9
1 of 12
No
No
Xtro\dhx29
1 of 12
No
No
Xtro\dhx30
1 of 12
No
No
Xtro\dhx34
1 of 12
No
No
Xtro\dhx36
1 of 12
No
No
Xtro\dhx37
1 of 12
No
No
Xtro\dqx1
1 of 12
No
Yes
Xtro\tdrd9
1 of 12
No
No
Xtro\ythdc2
1 of 12
No
No
Xtro\zcchc17
1 of 12
No
Yes
Danio rerio (Zebrafish) (19)
Drer\dhx16
14 of 15
Yes
Yes
Drer\dhx8
4 of 15
No
No
Drer\dhx15
4 of 15
No
No
Drer\dhx38
4 of 15
No
No
Drer\dhx32b
3 of 15
No
No
Drer\dhx33
3 of 15
No
No
Drer\dhx40
3 of 15
No
Yes
Drer\zgc:158828
3 of 15
No
No
Drer\dhx32a
2 of 15
No
No
Drer\dhx37
2 of 15
No
No
Drer\dqx1
2 of 15
No
Yes
Drer\LOC110438502
2 of 15
No
Yes
Drer\dhx29
1 of 15
No
No
Drer\dhx30
1 of 15
No
No
Drer\dhx34
1 of 15
No
No
Drer\dhx36
1 of 15
No
No
Drer\dhx57
1 of 15
No
No
Drer\tdrd9
1 of 15
No
No
Drer\zcchc17
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\mog-4
15 of 15
Yes
Yes
Cele\ddx-15
4 of 15
No
No
Cele\mog-1
4 of 15
No
No
Cele\mog-5
4 of 15
No
No
Cele\ddx-35
3 of 15
No
No
Cele\let-355
3 of 15
No
No
Cele\rha-2
2 of 15
No
No
Cele\F52B5.3
1 of 15
No
No
Cele\rha-1
1 of 15
No
No
Cele\smgl-2
1 of 15
No
No
Cele\T07D4.5
1 of 15
No
No
Cele\Y108F1.5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\ESP3
9 of 9
Yes
Yes
Atha\MEE29
8 of 9
No
Yes
Atha\AT4G16680
4 of 9
No
Yes
Atha\AT2G47250
2 of 9
No
No
Atha\AT3G26560
2 of 9
No
No
Atha\AT3G62310
2 of 9
No
No
Atha\EMB3011
2 of 9
No
No
Atha\AT1G26370
1 of 9
No
No
Atha\AT1G27900
1 of 9
No
No
Atha\AT4G18465
1 of 9
No
No
Atha\FAS4
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\PRP2
9 of 15
Yes
Yes
Scer\PRP16
3 of 15
No
No
Scer\PRP22
3 of 15
No
No
Scer\PRP43
3 of 15
No
No
Scer\DHR2
2 of 15
No
No
Scer\ECM16
1 of 15
No
No
Scer\YLR419W
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\cdc28
11 of 12
Yes
Yes
Spom\prp16
2 of 12
No
No
Spom\prp22
2 of 12
No
No
Spom\prp43
2 of 12
No
No
Spom\prh1
1 of 12
No
No
Spom\SPAC20H4.09
1 of 12
No
No
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dhx15
6 of 10
pea
6 of 10
Prp16
6 of 10
CG3225
5 of 10
CG4901
5 of 10
kz
4 of 10
CG1582
3 of 10
CG8915
3 of 10
CG32533
3 of 10
mle
3 of 10
Rhau
3 of 10
spn-E
3 of 10
bgcn
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DHX16; DEAH-box helicase 16
    14 of 15
    603405
      DHX8; DEAH-box helicase 8
      4 of 15
      600396
          DHX15; DEAH-box helicase 15
          4 of 15
          603403
              DHX38; DEAH-box helicase 38
              4 of 15
              605584
              DHX32; DEAH-box helicase 32 (putative)
              3 of 15
              607960
                  DHX33; DEAH-box helicase 33
                  3 of 15
                  614405
                      DHX35; DEAH-box helicase 35
                      3 of 15
                          DHX40; DEAH-box helicase 40
                          3 of 15
                          607570
                              DQX1; DEAQ-box RNA dependent ATPase 1
                              3 of 15
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Summary of Genetic Interactions
                                  esyN Network Diagram
                                  esyN Network Key:
                                  Suppression
                                  Enhancement
                                  View in Interactions Browser
                                  Please look at the allele data for full details of the genetic interactions
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  KLHL18
                                  enhanceable
                                  l(2)37Cb
                                  (Fujiyama-Nakamura et al., 2009)
                                  External Data
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                  External Data
                                  Linkouts
                                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  2L
                                  Recombination map
                                  2-54
                                  Cytogenetic map
                                  37C5-37C5
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  37C5-37C5
                                  Left limit from molecular mapping relative to l(2)37Da (FBrf0089206) Right limit from inclusion within Df(2L)hk-UC2 (FBrf0084402)
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  Experimentally Determined Recombination Data
                                  Location

                                  2-54

                                  (FlyBase, 2016)

                                  2-53.6

                                  (Comeron et al., 2012)

                                  2-53.9+

                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (7)
                                  Genomic Clones (12)
                                   

                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                  cDNA Clones (39)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     
                                    Commercially Available Antibodies
                                     
                                    Other Information
                                    Relationship to Other Genes
                                    Source for database identify of
                                    Source for database merge of

                                    Source for merge of: l(2)37Cb CG10689

                                    (FlyBase, 1996-)
                                    Additional comments
                                    Other Comments

                                    Located between coordinates +7.3 and +10.5.

                                    (Stathakis et al., 1995)

                                    Complementation analysis of the 7.6kb PstI fragment demonstrates this fragment carries the Ddc gene alone.

                                    (Marsh et al., 1985)
                                    Origin and Etymology
                                    Discoverer
                                    Etymology
                                    Identification
                                    External Crossreferences and Linkouts ( 40 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    modMine - A data warehouse for the modENCODE project
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    FlyMine - An integrated database for Drosophila genomics
                                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Synonyms and Secondary IDs (6)
                                    Datasets (8)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (8)
                                    Result
                                    Result Type
                                    Title
                                    scRNAseq_2020_Cattenoz_NI_seq_clustering
                                    Clustering analysis of hemocytes from non-infested third instar larvae
                                    scRNAseq_2020_Cattenoz_WI_seq_clustering
                                    Clustering analysis of hemocytes from wasp-infested third instar larvae
                                    scRNAseq_2020_Cho_NI72LG_seq_clustering
                                    Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
                                    scRNAseq_2020_Cho_NI96LG_seq_clustering
                                    Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
                                    scRNAseq_2020_Cho_NI120LG_seq_clustering
                                    Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
                                    scRNAseq_2020_Cho_WI96LG_seq_clustering
                                    Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
                                    scRNAseq_2020_Cho_NI96HL_seq_clustering
                                    Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
                                    scRNAseq_2020_Cho_NI120HL_seq_clustering
                                    Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
                                    References (49)