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Gene Dmel\l(2)37Cb

General Information
Symbol	Dmel\l(2)37Cb	Species	D. melanogaster
Name	lethal (2) 37Cb	Annotation symbol	CG10689
Feature type	protein_coding_gene	FlyBase ID	FBgn0086444
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Cb
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.9+
Cytogenetic map	37C5-37C5	Sequence location	2L:19,123,998..19,126,976 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) 37Cb is referred to in FlyBase by the symbol Dmel\l(2)37Cb (CG10689, FBgn0086444). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent RNA helicase activity; RNA helicase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 39 alleles are reported. The phenotype of these alleles is annotated with: adult thorax. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Domain of unknown function DUF1605; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; Helicase-associated domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1635225_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of l(2)37Cb. Gene sequence location is 2L:19123998..19126976.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37C5-37C5   Left limit from molecular mapping relative to l(2)37Da (FBrf0089206) Right limit from inclusion within Df(2L)hk-UC2 (FBrf0084402)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-53.9+
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)37Cb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)37Cb-RA FBtr0081163  NM_136102   2791   894
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)37Cb-PA   FBpp0080706   102.8   894   6.49     NP_609946   AAF53766
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) Domain of unknown function DUF1605 (IPR011709) Helicase-associated domain (IPR007502) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase, C-terminal (IPR001650) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA941520   AE014134 AAF53766   AI531229   AW942808   AY061330 AAL28878   BH023751   BI357458   BI361925   BI374437   BI581956   BI613666   BI617848   BI620195   BI626062   CO196343   CO262832   CO326141   CO341682   EC052067   EC055111   EC055554   EC056655   EC060473   EC074355   EC217054   EC219493   EC257671   EC258305   FE863514   FE863589   FE863644   FE863669   FE863720   FE863774   FE863833   FE863900   GH740608   GH741753   GH742108   GH761420   GH768344   GH768987   GH779802
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VIZ3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   garland cell primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium garland cell primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    112.2 Larval Midgut    30.8 Larval Hindgut    40.9 Larval Malpighian Tubules    35.8 Larval Fat Body    35.3 Larval Salivary Gland    68.5 Larval Trachea    55.025 Larval Carcass    49.75 Adult Head    30.8 Adult Eye    28.85 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    58.8 Adult Crop    45.1 Adult Midgut    34 Adult Hindgut    39.2 Adult Malpighian Tubules    39.2 Adult Fat Body    30.3 Adult Salivary Gland    43.3 Adult Heart    29.15 Adult VirginFemale Spermatheca    28.2 Adult InseminatedFemale Spermatheca    26.9 Adult Ovary    79.3 Adult Testis    27.6 Adult Male Accessory Gland    37.7 Adult Carcass    39.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30.8   NA  Eye    28.85   NA  Brain    53.1   112.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    58.8   NA  Crop    45.1   no informative data  Midgut    no informative data   40.9  Hindgut    39.2   35.8  Malpighian Tubules    39.2   35.3  Fat Body    30.3   68.5  Salivary Gland    no informative data   NA  Heart    29.15   55.025  Trachea    NA   NA  VirginFemale Spermatheca    28.2   NA  InseminatedFemale Spermatheca    26.9   NA  Ovary    79.3   NA  Testis    27.6   NA  Male Accessory Gland    37.7   49.75  Carcass    39.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    17 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    10 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr  (29) embryo 06-08hr  (28) embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr  29 embryo 06-08hr  28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    17 embryo 04-06hr    29 embryo 06-08hr    28 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    9 embryo 14-16hr    8 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    6 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    5 adult male 30day    5 adult female 01day    9 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2  26 embryonic Kc167  (35) embryonic S1  (35) embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (28) wing disc ML-DmD21  (29) wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  (30) antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2    13 ovary fGS/OSS  (32) ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2  26 embryonic Kc167  (35) embryonic S1  (35) embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9  32 wing disc ML-DmD16-c3  28 wing disc ML-DmD21  29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  29 tumorous blood cells mbn2    13 ovary fGS/OSS  32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    26 embryonic Kc167    35 embryonic S1    35 embryonic S3    19 leg disc CME L1    18 wing disc CME-W2    19 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • CG10689 LD25692 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086444 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10689-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for l(2)37Cb Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal l(2)37Cb30 l(2)37CbGD7065 lethal, with Scer\GAL4pnr-MD237 l(2)37CbGD7065 lethal | adult stage, with Scer\GAL4pnr-MD237 l(2)37CbGD7065 lethal | heat sensitive l(2)37Cb3 l(2)37Cbts1 l(2)37Cbts2 lethal | larval stage l(2)37Cb1 l(2)37Cb8 l(2)37Cb20 lethal | recessive l(2)37Cb1 l(2)37Cb2 Sterility Allele fertile l(2)37Cb3 l(2)37Cbts2 Other Phenotypes Allele neuroanatomy defective | larval stage l(2)37CbGD7065 visible, with Scer\GAL4pnr-MD237 l(2)37CbNIG.10689R wild-type l(2)37Cb+t4.0 l(2)37Cb+t6.6 Phenotype manifest in Allele adult thorax, with Scer\GAL4pnr-MD237 l(2)37CbNIG.10689R embryonic/larval neuroblast | larval stage l(2)37CbGD7065 ganglion mother cell | larval stage l(2)37CbGD7065
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of l(2)37Cb Class Mutagen Stocks Known lesion l(2)37Cb18 ethyl methanesulfonate gamma ray 1 Yes l(2)37Cb1 ethyl methanesulfonate 1 -- l(2)37CbBG01776 P-element activity 1 -- l(2)37CbEY01114 1 -- l(2)37Cb10 ethyl methanesulfonate 0 -- l(2)37Cb11 ethyl methanesulfonate 0 -- l(2)37Cb12 ethyl methanesulfonate 0 -- l(2)37Cb13 ethyl methanesulfonate 0 -- l(2)37Cb14 ethyl methanesulfonate 0 -- l(2)37Cb15 ethyl methanesulfonate 0 -- l(2)37Cb16 ethyl methanesulfonate 0 -- l(2)37Cb17 ethyl methanesulfonate 0 -- l(2)37Cb19 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb20 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb21 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb22 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb23 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb24 ethyl methanesulfonate 0 -- l(2)37Cb25 ethyl methanesulfonate 0 -- l(2)37Cb26 ethyl methanesulfonate 0 -- l(2)37Cb27 ethyl methanesulfonate 0 -- l(2)37Cb28 ethyl methanesulfonate 0 -- l(2)37Cb29 ethyl methanesulfonate 0 -- l(2)37Cb2 ethyl methanesulfonate 0 -- l(2)37Cb30 ethyl methanesulfonate gamma ray 0 -- l(2)37Cb3 ethyl methanesulfonate 0 -- l(2)37Cb4 ethyl methanesulfonate 0 -- l(2)37Cb5 ethyl methanesulfonate 0 -- l(2)37Cb6 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cb7 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cb8 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cb9 ethyl methanesulfonate gamma ray 0 -- l(2)37Cbts1 ethyl methanesulfonate 0 -- l(2)37Cbts2 ethyl methanesulfonate formaldehyde 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)37Cb Class Mutagen Stocks Known lesion l(2)37CbGD7065 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes l(2)37Cb+t4.0 in vitro construct - genomic fragment 0 Yes l(2)37Cb+t6.6 in vitro construct - genomic fragment 0 Yes l(2)37CbC7 in vitro construct - genomic fragment 0 Yes l(2)37CbNIG.10689R in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)E71 (Wright et al., 1981) Df(2L)Exel6042 (Ryder, 2004.4.26) Df(2L)Exel8040 (Ryder, 2004.4.26) Df(2L)hk-UC2 (Stathakis et al., 1995, Wright, 1996) Df(2L)NST (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)TW50 (Wright et al., 1976) Df(2L)TW130 (Wright et al., 1976, Wright et al., 1981, Gilbert et al., 1984, Stathakis et al., 1995, Wright, 1996) Df(2L)VA17 (Wright et al., 1981, Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA21 (Stathakis et al., 1995, Wright, 1996) Df(2L)VA23 (Stathakis et al., 1995)
Not disrupted in	Df(2L)E55 (Stathakis et al., 1995) Df(2L)hk18 (Gilbert et al., 1984, Pentz et al., 1986, Wright, 1996) Df(2L)hk-UC1 (Stathakis et al., 1995, Wright, 1996) Df(2L)OD15 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)Sd37 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd57 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd77 (Stathakis et al., 1995, Wright, 1996) Df(2L)TE37C-1 (Wright et al., 1981, Wright, 1996) Df(2L)TE37C-7 (Stathakis et al., 1995, Wright, 1996) Df(2L)TW137 (Stathakis et al., 1995) Df(2L)TW203 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA12 (Wright et al., 1981, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA13 (Wright et al., 1981, Wright, 1996) Df(2L)VA18 (Pentz et al., 1986, Stathakis et al., 1995) Df(2L)VA19 (Stathakis et al., 1995, Wright, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7065} NA characterization construct P{NIG.10689R} NA P{pC3} NA P{pC6} NA P{pC7} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}l(2)37CbBG01776 NA insertion of mobile activating element P{EPgy2}l(2)37CbEY01114 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR002464, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity inferred from sequence or structural similarity with Saccharomyces PRP2 (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR002464, InterPro:IPR011545 (FlyBase Curators et al., 2004-) RNA helicase activity inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity with NCBI:NP_003578 AND inferred from sequence or structural similarity with Saccharomyces PRP2 (Mount and Salz, 2000) inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
spliceosomal complex inferred from sequence or structural similarity with NCBI:NP_003578 AND inferred from sequence or structural similarity with Saccharomyces PRP2 (Mount and Salz, 2000) inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(2)37Cb - ALiX anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG10802 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG11437 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG13601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG2121 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG31712 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - CG31910 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG32485 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG32812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG33514 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG33523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG3542 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG4119 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG5805 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG6686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CanB2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Crk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - GstO3 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - Ir93a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Pi3K59F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Sh3β experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - Smox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - TpnC25D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - Wwox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - awd experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - eIF-4E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - lft anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - noi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - regucalcin experimental knowledge based (Guruharsha et al., 2011) l(2)37Cb - roq anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - shtd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cb - γSnap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)37Cb allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61176 DroID - A comprehensive database of gene and protein interactions. • FBgn0086444 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35192
Orthologs
OrthoDB Orthologs (66) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG608NTD Dipteran inclusive ortholog search EOG6V43GQ Insect inclusive ortholog search EOG6XWDSR Arthropod inclusive ortholog search EOG6866TF Metazoa inclusive ortholog search EOG6JMMGF
Orthologs in Drosophila Species (EOG608NTD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(2)37Cb     Drosophila simulans   Dsim\GD21776     Drosophila sechellia   Dsec\GM17027     Drosophila erecta   Dere\GG21648     Drosophila yakuba   Dyak\GE12668     Drosophila ananassae   Dana\GF15208     Drosophila pseudoobscura pseudoobscura   Dpse\GA10497     Drosophila persimilis   Dper\GL21126     Drosophila willistoni   Dwil\GK24234     Drosophila virilis   Dvir\GJ17992     Drosophila mojavensis   Dmoj\GI17233     Drosophila grimshawi   Dgri\GH13481
Orthologs in non-Drosophila Dipterans (EOG6V43GQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010732   Anopheles gambiae Malaria mosquito  Agam\AGAP009093   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003520
Orthologs in non-Dipteran Insects (EOG6XWDSR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50695   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001286   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16950   Atta cephalotes Leafcutter ant  Acep\ACEP21378   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18896   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13637   Linepithema humile Argentine ant  Lhum\LH11097   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20775   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006790   Acyrthosiphon pisum Pea aphid  Apim\ACYPI087151   Bombyx mori Silkmoth  Bmor\BGIBMGA003195   Pediculus humanus Human body louse  Phum\PHUM410360   Tribolium castaneum Red flour beetle  Tcas\TC013528
Orthologs in non-Insect Arthropods (EOG6866TF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306213   Ixodes scapularis Deer tick  Isca\ISCW005462
Orthologs in non-Arthropod Metazoa (EOG6JMMGF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mog-4 Y Caenorhabditis elegans Nematode  Cele\mog-1 Y Caenorhabditis elegans Nematode  Cele\mog-5 Y Caenorhabditis elegans Nematode  Cele\F56D2.6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006940gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006038gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017153gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011155gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010853gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007417gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024623gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028381gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025209gn Y Danio rerio Zebrafish  Drer\dhx15 Y Danio rerio Zebrafish  Drer\dhx16 Y Danio rerio Zebrafish  Drer\dhx38 Y Danio rerio Zebrafish  Drer\dhx8 Y Xenopus tropicalis Western clawed frog  Xtro\dhx15 Y Xenopus tropicalis Western clawed frog  Xtro\dhx16 Y Xenopus tropicalis Western clawed frog  Xtro\dhx38 Y Xenopus tropicalis Western clawed frog  Xtro\dhx8 Y Gallus gallus Domestic chicken  Ggal\DHX38 Y Gallus gallus Domestic chicken  Ggal\DHX15 Y Gallus gallus Domestic chicken  Ggal\LOC771596 Y Mus musculus House mouse  Mmus\Dhx16 Y Mus musculus House mouse  Mmus\Dhx38 Y Mus musculus House mouse  Mmus\Dhx8 Y Mus musculus House mouse  Mmus\Dhx15 Y Rattus norvegicus Norway rat  Rnor\Dhx8 Y Rattus norvegicus Norway rat  Rnor\Dhx38 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030157 Y Rattus norvegicus Norway rat  Rnor\Dhx15 Y Homo sapiens Human  Hsap\DHX8 Y Homo sapiens Human  Hsap\DHX16 Y Homo sapiens Human  Hsap\DHX38 Y Homo sapiens Human  Hsap\DHX15 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\DHX8     Hsap\DHX16     Hsap\DHX38     Hsap\DHX15
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	5388 l(2)37Cb18 pr1 or49h/CyO 15495 y1 w67c23; P{EPgy2}l(2)37CbEY01114 3281 rdo1 hk1 l(2)37Cb1 pr1/CyO 12759 y1 w1118; P{GT1}l(2)37CbBG01776/CyO
VDRC	v31324 w1118; P{GD7065}v31324 v31325 w1118; P{GD7065}v31325 v39764 w1118; P{GD7065}v39764/TM3
Genomic Clones ( 2 )
	BACR04C20 BACR48O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25692
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE43952 RE46341 RE62026 RH19810 RH42873 RH48307 RH51272 RH66591 SD02174
Other clones	10831 60118 214415.28 214481.19 CK01.102D.F8 CK01.113D.F8 EC052067 EC055111 EC055554 EC056655 EK003140 EK086456 EP03316 EP12942 RM07441 RM07541 RM07641 RM07741 RM07841 RM07941 RM08041 RM08141 RP01121 RP001003083 RP001006815 RP001029923 RP001036890 RP001040606 RP001046985
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086444 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35192
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)37Cb CG10689 (FlyBase, 1996-)
Additional comments
Other Comments
	Located between coordinates +7.3 and +10.5. (Stathakis et al., 1995) Complementation analysis of the 7.6kb PstI fragment demonstrates this fragment carries the Ddc gene alone. (Marsh et al., 1985)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136102 RefSeq (Proteins) • NP_609946 DDBJ / EMBL / GenBank • AA941520 AAF53766 AAL28878 AW942808 AY061330 BH023751 Entrez Gene - A searchable database of RefSeq genes. • 35192 UniProtKB/TrEMBL • Q9VIZ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) Domain of unknown function DUF1605 (IPR011709) Helicase-associated domain (IPR007502) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase, C-terminal (IPR001650) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG10689 LD25692
Linkouts
	BioGRID - A database of protein and genetic interactions • 61176 DroID - A comprehensive database of gene and protein interactions. • FBgn0086444 DRSC - Results from RNAi screens. • FBgn0086444 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086444 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10689-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086444 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35192 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35192 modMine - Data generated by the modENCODE project. • FBgn0086444
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Cb (Wright, 1996, McCrady and Tolin, 1994) CG10689 (FlyBase, 1996-, Fujiyama-Nakamura et al., 2009, Herold et al., 2009, Liebl and Featherstone, 2005) cg10689 (Lasko, 2000) l(2)37Cb (FlyBase, 1996-, McCrady and Tolin, 1994, Fujiyama-Nakamura et al., 2009, Neumüller et al., 2011) l(2)E104 (Wright et al., 1976, )
Name Synonym	CG10689   lethal (2) 37Cb
Secondary FlyBase IDs
	FBgn0002030 FBgn0032759
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...