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Gene Dmel\l(2)37Cd

General Information
Symbol	Dmel\l(2)37Cd	Species	D. melanogaster
Name	lethal (2) 37Cd	Annotation symbol	CG10563
Feature type	protein_coding_gene	FlyBase ID	FBgn0086445
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Cd
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.9+
Cytogenetic map	37C5-37C5	Sequence location	2L:19,127,262..19,129,326 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) 37Cd is referred to in FlyBase by the symbol Dmel\l(2)37Cd (CG10563, FBgn0086445). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 16 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; wing; melanotic mass. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcription factor IIIC, subunit 5. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1634729_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of l(2)37Cd. Gene sequence location is 2L:19127262..19129326.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)37Cd Late third-instar larval lethal; some form unsclerotized pseudopupae after ten days; imaginal discs and central nervous system half normal size; melanotic tumors [l(2)37Cd4].
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA02069 BKN22827
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37C5-37C5   Left limit from inclusion within Df(2L)VA21 (FBrf0084402) Right limit from non-inclusion within Df(2L)VA12 (FBrf0035993)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-53.9+
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)37Cd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)37Cd-RA FBtr0081156  NM_136103   1819   480
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)37Cd-PA   FBpp0080700   55.6   480   4.98     NP_609947   AAF53767
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor IIIC, subunit 5 (IPR019136)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391023   AA567323   AA941690   AE014134 AAF53767   AI135470   AI513242   AY051463 AAK92887   BH809459   BH809460   BI171507   BI216410   BI227952   BI227975   BI233120   BI361964   BI367159   BI577520   BT021274 AAX33422   CO295664   CO305490   CO306035   EC088887   EC247423   GH950635   GH952647   GH953092   GH971723
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VIZ2 Q961P2 Q5BIF0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086445    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086445 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086445 expression level Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1904) embryo 02-04hr  (1694) embryo 04-06hr  (830) embryo 06-08hr  (839) embryo 08-10hr  (854) embryo 10-12hr  (584) embryo 12-14hr  (520) embryo 14-16hr  (586) embryo 16-18hr  (484) embryo 18-20hr  (271) embryo 20-22hr  (562) embryo 22-24hr  (576) larva L1  (228) larva L2  (251) larva L3 12hr old  (233) larva L3 puffstage 1-2  (265) larva L3 puffstage 3-6  (320) larva L3 puffstage 7-9  (339) white prepupae new  (298) white prepupae 12hr  (373) white prepupae 24hr  (367) pupae 2d postWPP  (291) pupae 3d postWPP  (239) pupae 4d postWPP  (164) adult male 01day  (233) adult male 05day  (275) adult male 30day  (286) adult female 01day  (537) adult female 05day  (954) adult female 30day  (995) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1904) embryo 02-04hr  (1694) embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086445 expression level Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1904) embryo 02-04hr  (1694) embryo 04-06hr  (830) embryo 06-08hr  (839) embryo 08-10hr  (854) embryo 10-12hr  (584) embryo 12-14hr  (520) embryo 14-16hr  (586) embryo 16-18hr  (484) embryo 18-20hr  (271) embryo 20-22hr  (562) embryo 22-24hr  (576) larva L1  (228) larva L2  (251) larva L3 12hr old  (233) larva L3 puffstage 1-2  (265) larva L3 puffstage 3-6  (320) larva L3 puffstage 7-9  (339) white prepupae new  (298) white prepupae 12hr  (373) white prepupae 24hr  (367) pupae 2d postWPP  (291) pupae 3d postWPP  (239) pupae 4d postWPP  (164) adult male 01day  (233) adult male 05day  (275) adult male 30day  (286) adult female 01day  (537) adult female 05day  (954) adult female 30day  (995) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1904 embryo 02-04hr  1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1904 embryo 02-04hr    1694 embryo 04-06hr    830 embryo 06-08hr    839 embryo 08-10hr    854 embryo 10-12hr    584 embryo 12-14hr    520 embryo 14-16hr    586 embryo 16-18hr    484 embryo 18-20hr    271 embryo 20-22hr    562 embryo 22-24hr    576 larva L1    228 larva L2    251 larva L3 12hr old    233 larva L3 puffstage 1-2    265 larva L3 puffstage 3-6    320 larva L3 puffstage 7-9    339 white prepupae new    298 white prepupae 12hr    373 white prepupae 24hr    367 pupae 2d postWPP    291 pupae 3d postWPP    239 pupae 4d postWPP    164 adult male 01day    233 adult male 05day    275 adult male 30day    286 adult female 01day    537 adult female 05day    954 adult female 30day    995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086445    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086445 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086445 expression level Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086445 expression level Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    73.05 Larval Midgut    34.3 Larval Hindgut    34.3 Larval Malpighian Tubules    46.8 Larval Fat Body    27 Larval Salivary Gland    34.1 Larval Trachea    31.925 Larval Carcass    30.125 Adult Head    47.4 Adult Eye    31.3 Adult Brain    66.8 Adult Thoracic-Abdominal Ganglion    64.5 Adult Crop    58.3 Adult Midgut    39.1 Adult Hindgut    38 Adult Malpighian Tubules    31.1 Adult Fat Body    27.1 Adult Salivary Gland no informative data Adult Heart    22.175 Adult VirginFemale Spermatheca    18.5 Adult InseminatedFemale Spermatheca    31.7 Adult Ovary    224.4 Adult Testis    43.8 Adult Male Accessory Gland    30.8 Adult Carcass    29.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    47.4   NA  Eye    31.3   NA  Brain    66.8   73.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    64.5   NA  Crop    58.3   34.3  Midgut    39.1   34.3  Hindgut    38   46.8  Malpighian Tubules    31.1   27  Fat Body    27.1   34.1  Salivary Gland    no informative data   NA  Heart    22.175   31.925  Trachea    NA   NA  VirginFemale Spermatheca    18.5   NA  InseminatedFemale Spermatheca    31.7   NA  Ovary    224.4   NA  Testis    43.8   NA  Male Accessory Gland    30.8   30.125  Carcass    29.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086445 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10563-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage l(2)37Cd7 lethal | pupal stage l(2)37Cd5 Other Phenotypes Allele body color defective | recessive l(2)37Cd5 l(2)37Cdts1 melanotic mass phenotype l(2)37Cd1 l(2)37Cd4 l(2)37Cd6 l(2)37Cd7 wild-type l(2)37Cd+t2.2 Phenotype manifest in Allele adult abdomen & adult cuticle l(2)37Cd1 l(2)37Cd2 l(2)37Cd5 l(2)37Cd8 l(2)37Cdts1 adult abdomen | dorsal l(2)37Cd1 l(2)37Cd2 l(2)37Cd5 l(2)37Cd8 l(2)37Cdts1 adult abdomen | female l(2)37Cd1 l(2)37Cd2 l(2)37Cd5 l(2)37Cd8 l(2)37Cdts1 macrochaeta l(2)37Cd1 l(2)37Cd2 l(2)37Cd5 l(2)37Cd8 l(2)37Cdts1 melanotic mass l(2)37Cd1 l(2)37Cd4 l(2)37Cd6 l(2)37Cd7 wing l(2)37Cd1 l(2)37Cd2 l(2)37Cd5 l(2)37Cd8 l(2)37Cdts1
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of l(2)37Cd Class Mutagen Stocks Known lesion l(2)37Cd1 ethyl methanesulfonate 2 -- l(2)37CdKG04199 P-element activity 1 -- l(2)37Cd10 ethyl methanesulfonate gamma ray 0 -- l(2)37Cd2 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cd3 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cd4 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cd5 ethyl methanesulfonate 0 -- l(2)37Cd6 ethyl methanesulfonate 0 -- l(2)37Cd7 ethyl methanesulfonate gamma ray 0 Yes l(2)37Cd8 ethyl methanesulfonate gamma ray 0 -- l(2)37Cd9 ethyl methanesulfonate gamma ray 0 -- l(2)37Cdts1 ethyl methanesulfonate formaldehyde 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)37Cd Class Mutagen Stocks Known lesion l(2)37CdKK102731 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)37Cd+t2.2 in vitro construct - genomic fragment 0 Yes l(2)37CdC9 in vitro construct - genomic fragment 0 Yes l(2)37CdGD6709 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)E71 (Wright et al., 1981) Df(2L)Exel6042 (Ryder, 2004.4.26) Df(2L)Exel8040 (Ryder, 2004.4.26) Df(2L)NST (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)TW130 (Wright et al., 1981, Gilbert et al., 1984, Stathakis et al., 1995, Wright, 1996) Df(2L)VA17 (Wright et al., 1981, Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA21 (Stathakis et al., 1995, Wright, 1996) Df(2L)VA23 (Stathakis et al., 1995)
Not disrupted in	Df(2L)E55 (Stathakis et al., 1995) Df(2L)hk18 (Gilbert et al., 1984, Pentz et al., 1986, Wright, 1996) Df(2L)hk-UC1 (Stathakis et al., 1995, Wright, 1996) Df(2L)hk-UC2 (Stathakis et al., 1995) Df(2L)OD15 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)Sd37 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd57 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd77 (Stathakis et al., 1995, Wright, 1996) Df(2L)TE37C-1 (Wright et al., 1981, Wright, 1996) Df(2L)TE37C-7 (Stathakis et al., 1995, Wright, 1996) Df(2L)TW137 (Stathakis et al., 1995) Df(2L)TW203 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA12 (Wright et al., 1981, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA13 (Wright et al., 1981, Wright, 1996) Df(2L)VA18 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA19 (Stathakis et al., 1995, Wright, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6709} NA P{KK102731} NA characterization construct P{pC8} NA P{pC9} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0897SH0897 No miscellaneous insertions P{SUPor-P}l(2)37CdKG04199 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)37Cd allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0086445 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35193
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA10397
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009331-PA Aedes aegypti (mosquito) AGAP009321-PA Anopheles gambiae (mosquito) XP_001122915.1 Apis mellifera (honey bee) At3g49410.1 Arabidopsis thaliana (wall cress) 91486 Batrachochytrium dendrobatidis (chytrid fungus) 57181 Branchiostoma floridae (lancelet) XP_001897843.1 Brugia malayi (roundworm nematode) BGIBMGA003127-PA Bombyx mori (silk worm) ENSBTAP00000028493 Bos taurus (bovine) CAL0003581 Candida albicans (a form of yeast) CN14392 Caenorhabditis brenneri (small nematode) CBP27724 Caenorhabditis briggsae (nematode) CE01063 Caenorhabditis elegans (worm) ENSCAFP00000029444 Canis familiaris (dog) Chro.20083 Cryptosporidium hominis (obligate parasite) JA18216 Caenorhabditis japonica (nematode) cn02230 Cryptococcus neoformans (yeast-like fungus) cgd2_730 Cryptosporidium parvum (protozoan parasite) CPIJ007067 Culex pipens (mosquito) ENSCPOP00000010017 Cavia porcellus (guinea pig) 168625 Chlamidomonas reinhardtii (green alga) RP39836 Caenorhabditis remanei (nematode) ENSCSAVP00000016240 Ciona savignyi (sedentary tunicate) 224553 Capitella spl (polychaete worm) DDB0231091 Dictyostelium discoideum (amoeba) DEHA2B03102g Debaryomyces Hansenii (yeast) 310750 Daphnia pulex (daphnia) ENSECAP00000007001 Equus caballus (horse) ENSGACP00000023959 Gymnopilus aculeatus (mushroom) ENSGALP00000005439 Gallus gallus (chicken) 189301 Hypsipyla robusta (cedar shoot borer) ENSP00000361180 Homo sapiens (human) ISCW023432-PA Ixodes scapularis (deer tick) KLLA0B08866g Kluyveromyces lactis (yeast) 229926 Lottia gigantea (owl limpet) 23213 Monocosta brevicollis (choanoflagellate) ENSMODP00000029433 Monodelphis domestica (gray opossum) ENSMMUP00000001694 Macaca mulatta (rhesus monkey) ENSMUSP00000109521 Mus musculus (house mouse) 199476 Nematostella vectensis (starlet anemone) XP_001603262.1 Nasonia vitripennis (wasp) ENSOANP00000023200 Ornithorynchus anatinus (platypus) ENSORLP00000018064 Oryzias latipes (japanese killifish) PFL0520c Plasmodium falciparum (protozoal parasite) PHUM008663-PA Pediculus humanus (human body louse) PP02331 Pristionchus pacificus (nematode) 136248 Physcomitrella patens (moss) ENSPPYP00000003224 Pongo pygmaeus (orangutan) 78993 Phytophthora ramorum (sudden oak death pathogen) 135869 Phytophthora sojae (root rot pathogen) 778154 Populus trichocarpa (black cottonwood) ENSPTRP00000048749 Pan troglodytes (chimpanzee) PVX_084555 Plasmodium vivax (protozoal parasite) ENSRNOP00000015068 Rattus norvegicus (norway rat) 142523 Sorghum bicolor (sorghum) Smp_050740 Schistosoma mansoni (trematode parasite) SPAC6F12.11c Schizosaccharomyces pombe (fission yeast) XP_001810629.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008334 Tetraodon nigroviridis (green spotted pufferfish) 86498.m00601 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000013729 Xenopus tropicalis (frog) YALI0E14663g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17864 NV12408 LH17044 ISCW023432 FBgn0230927 FBgn0226753 FBgn0205404 FBgn0195538 FBgn0172238 JGI_V11_310750 FBgn0070454 FBgn0158782 FBgn0136739 FBgn0120913 FBgn0113343 FBgn0091731 CPIJ007067 BGIBMGA003127 GB17002 AGAP009321 AAEL009331 PHUM626410 GLEAN_10945
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	3385 l(2)37Cd1 pr1/CyO 13975 y1; P{SUPor-P}l(2)37CdKG04199/CyO; ry506
Kyoto	107024 l(2)37Cd1 pr1/CyO
VDRC	v108316 P{KK102731}VIE-260B
Genomic Clones ( 2 )
	BACR04C20 BACR48O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13253 RE46634
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01041 LD09966 LD27048 RE13296 RE23536 RE25344 RE25368 RE29405 RE46404 RE52866 RE71213
Other clones	77875 147334 EK211310 EK248803 EK250137 RP004134692 RP004141158 RP004171071 RP004407806
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086445 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35193 49169
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)37Cd CG10563 (FlyBase, 1996-)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Located between coordinates +11.6 and +12.4. (Stathakis et al., 1995) Complementation analysis of the 7.6kb PstI fragment demonstrates this fragment carries the Ddc gene alone. (Marsh et al., 1985) late L3 larval lethal; some form unsclerotized pseudopupae after ten days; imaginal discs and central nervous system half normal size.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136103 RefSeq (Proteins) • NP_609947 DDBJ / EMBL / GenBank • AAF53767 AAK92887 AAX33422 AI135470 AI513242 AY051463 BH809459 BH809460 BT021274 Entrez Gene - A searchable database of RefSeq genes. • 35193 UniProtKB/TrEMBL • Q5BIF0 Q9VIZ2 Q961P2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor IIIC, subunit 5 (IPR019136)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0086445 DRSC - Results from RNAi screens. • FBgn0086445 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086445 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10563-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086445 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35193 49169 InParanoid A subset of ortholog calls from InParanoid. • AAEL009331-PA Aedes aegypti (mosquito) AGAP009321-PA Anopheles gambiae (mosquito) XP_001122915.1 Apis mellifera (honey bee) At3g49410.1 Arabidopsis thaliana (wall cress) 91486 Batrachochytrium dendrobatidis (chytrid fungus) 57181 Branchiostoma floridae (lancelet) XP_001897843.1 Brugia malayi (roundworm nematode) BGIBMGA003127-PA Bombyx mori (silk worm) ENSBTAP00000028493 Bos taurus (bovine) CAL0003581 Candida albicans (a form of yeast) CN14392 Caenorhabditis brenneri (small nematode) CBP27724 Caenorhabditis briggsae (nematode) CE01063 Caenorhabditis elegans (worm) ENSCAFP00000029444 Canis familiaris (dog) Chro.20083 Cryptosporidium hominis (obligate parasite) JA18216 Caenorhabditis japonica (nematode) cn02230 Cryptococcus neoformans (yeast-like fungus) cgd2_730 Cryptosporidium parvum (protozoan parasite) CPIJ007067 Culex pipens (mosquito) ENSCPOP00000010017 Cavia porcellus (guinea pig) 168625 Chlamidomonas reinhardtii (green alga) RP39836 Caenorhabditis remanei (nematode) ENSCSAVP00000016240 Ciona savignyi (sedentary tunicate) 224553 Capitella spl (polychaete worm) DDB0231091 Dictyostelium discoideum (amoeba) DEHA2B03102g Debaryomyces Hansenii (yeast) 310750 Daphnia pulex (daphnia) ENSECAP00000007001 Equus caballus (horse) ENSGACP00000023959 Gymnopilus aculeatus (mushroom) ENSGALP00000005439 Gallus gallus (chicken) 189301 Hypsipyla robusta (cedar shoot borer) ENSP00000361180 Homo sapiens (human) ISCW023432-PA Ixodes scapularis (deer tick) KLLA0B08866g Kluyveromyces lactis (yeast) 229926 Lottia gigantea (owl limpet) 23213 Monocosta brevicollis (choanoflagellate) ENSMODP00000029433 Monodelphis domestica (gray opossum) ENSMMUP00000001694 Macaca mulatta (rhesus monkey) ENSMUSP00000109521 Mus musculus (house mouse) 199476 Nematostella vectensis (starlet anemone) XP_001603262.1 Nasonia vitripennis (wasp) ENSOANP00000023200 Ornithorynchus anatinus (platypus) ENSORLP00000018064 Oryzias latipes (japanese killifish) PFL0520c Plasmodium falciparum (protozoal parasite) PHUM008663-PA Pediculus humanus (human body louse) PP02331 Pristionchus pacificus (nematode) 136248 Physcomitrella patens (moss) ENSPPYP00000003224 Pongo pygmaeus (orangutan) 78993 Phytophthora ramorum (sudden oak death pathogen) 135869 Phytophthora sojae (root rot pathogen) 778154 Populus trichocarpa (black cottonwood) ENSPTRP00000048749 Pan troglodytes (chimpanzee) PVX_084555 Plasmodium vivax (protozoal parasite) ENSRNOP00000015068 Rattus norvegicus (norway rat) 142523 Sorghum bicolor (sorghum) Smp_050740 Schistosoma mansoni (trematode parasite) SPAC6F12.11c Schizosaccharomyces pombe (fission yeast) XP_001810629.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008334 Tetraodon nigroviridis (green spotted pufferfish) 86498.m00601 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000013729 Xenopus tropicalis (frog) YALI0E14663g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35193 modMine - Data generated by the modENCODE project. • FBgn0086445 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17864 NV12408 LH17044 ISCW023432 FBgn0230927 FBgn0226753 FBgn0205404 FBgn0195538 FBgn0172238 JGI_V11_310750 FBgn0070454 FBgn0158782 FBgn0136739 FBgn0120913 FBgn0113343 FBgn0091731 CPIJ007067 BGIBMGA003127 GB17002 AGAP009321 AAEL009331 PHUM626410 GLEAN_10945
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Cd (Wright, 1996, McCrady and Tolin, 1994) CG10563 (FlyBase, 1996-, Stroschein-Stevenson et al., 2006, Stone and Ayroles, 2009, Keleman et al., 2009.8.5) l(2)37Cd (FlyBase, 1996-, McCrady and Tolin, 1994, Ayroles et al., 2009, Telonis-Scott et al., 2009, Wright, 1987, Fujiyama-Nakamura et al., 2009)
Name Synonym	CG10563   lethal (2) 37Cd
Secondary FlyBase IDs
	FBgn0002032 FBgn0032760
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 2 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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