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Gene Dmel\su(r)

General Information
Symbol	Dmel\su(r)	Species	D. melanogaster
Name	suppressor of rudimentary	Annotation symbol	CG2194
Feature type	protein_coding_gene	FlyBase ID	FBgn0086450
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Dreg-3, Reg-3, Pyd1
Genomic Location
Chromosome (arm)	X	Recombination map	1-27.7
Cytogenetic map	8D1-8D1	Sequence location	X:9,090,841..9,095,849 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene suppressor of rudimentary is referred to in FlyBase by the symbol Dmel\su(r) (CG2194, FBgn0086450). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: dihydropyrimidine dehydrogenase (NADP+) activity. There is experimental evidence that it is involved in the biological process: 'de novo' pyrimidine nucleobase biosynthetic process. 20 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 4Fe-4S binding domain; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; 4Fe-4S ferredoxin-type, iron-sulpur binding domain; Aldolase-type TIM barrel; Alpha-helical ferredoxin; Dihydroorotate dehydrogenase domain; Dihydroorotate dehydrogenase, class 1/ 2; Dihydroorotate dehydrogenase, conserved site; Fumarate reductase, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult fat body, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, adult heart, adult salivary gland, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625686_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of su(r). Gene sequence location is X:9090841..9095849.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	su(r): suppressor of rudimentary Suppresses both the phenotypic effects and the female sterility of all r alleles; also suppresses the r phenocopying and lethal effects of 6-azauracil administration. Little or no dihydrouracil dehydrogenase (EC 1.3.99.11) activity. Thought to interfere with pyrimidine catabolism. Unable to degrade uracil and extremely sensitive to exogenous pyrimidine. Enhances the expression of dp and net, and causes b flies to have very black bodies, darker than wild type, especially along the wing veins; forms synthetic lethals in combination with tt and whd.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8D1-8D1   Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-27.7 (Bahn, 1972) 1-27 (Gojkovic, 2002.9.10)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\su(r) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) su(r)-RC FBtr0071338  NM_167182   3395   1031
Additional Transcript Data & Comments
Reported size (kB)	2.7 (northern blot) (van Gelder et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein su(r)-PC   FBpp0071273   111.2   1031   6.78     NP_727320   AAN09247
Additional Polypeptide Data & Comments
Reported size (kDa)	626 (aa) (van Gelder et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dihydroorotate dehydrogenase, class 1/ 2 (IPR012135) Dihydroorotate dehydrogenase, conserved site (IPR001295) Dihydroorotate dehydrogenase domain (IPR005720) Alpha-helical ferredoxin (IPR009051) Fumarate reductase, C-terminal (IPR012285) Aldolase-type TIM barrel (IPR013785) 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896) 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900) 4Fe-4S binding domain (IPR001450)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950505   AE014298 AAN09247   AF545061 AAN64918   AI062444   AI135525   AI135839   AI292586   AI386947   AI388542   AI405105   AI517613   AI532246   AI533370   AW940058   AY058259 AAL13488   BF491920   BF497947   BF500339   BF501778   BF503001   BG634497   BG636978   BG640321   BI170035   BI171741   BI235053   BI237577   BI241384   BI241460   BI243359   BI243784   BI353756   BI370195   BI485967   BI565990   BI569711   BI570146   BI578993   BI583694   BI584039   BI586411   BI587638   BI607325   BI621544   BI626118   BI626797   BI632656   BI633679   BI633828   BI637590   BI640649   BT032682   CO264172   CO267277   CO277801   CO282650   CO317240   CO335753   CZ487041   DQ027826 AAY44826   DQ257368   DQ257369   DQ257370   DQ257371   EC062093   EC076494   EC083754   EC198975   EC204107   EC221416   EC265933   EL874817   GH945441   GH948664   GH949666   GH958300   GH960060   GH960443   GH961185   GH963437   GH965099   GH967328   GH968283   GH974416   GH981550   GH982720   GH982985   U65491 AAC47288
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W374 Q95U76 Q4TWT4 Q94914
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late     (van Gelder et al., 1995) adult stage   adult head   (van Gelder et al., 1995)
Additional Descriptive Data
	su(r) transcripts are expressed with a circadian rhythm and show a single daily peak and trough of expression. The peak occurs at ZT 2 and the trough at ZT 14. The phase of expression could be altered by a change in the feeding time. Transcript levels continue to cycle in the absence of a light-dark cycle. Transcripts were detected in adult heads but not bodies and were also detected in late embryos. (van Gelder et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult fat body, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, adult heart, adult salivary gland, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca    1292.7 Adult InseminatedFemale Spermatheca    1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules  (819.9) Adult Fat Body  (828.5) Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca  (1292.7) Adult InseminatedFemale Spermatheca  (1070.7) Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca  (1292.7) Adult InseminatedFemale Spermatheca  1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca    1292.7 Adult InseminatedFemale Spermatheca    1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca    1292.7 Adult InseminatedFemale Spermatheca    1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules  (819.9) Adult Fat Body  (828.5) Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca  (1292.7) Adult InseminatedFemale Spermatheca  (1070.7) Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca  1292.7 Adult InseminatedFemale Spermatheca  1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.45 Larval Midgut    387.7 Larval Hindgut    92.6 Larval Malpighian Tubules    21.8 Larval Fat Body    33.3 Larval Salivary Gland    11.9 Larval Trachea    14.275 Larval Carcass    27.35 Adult Head    174.3 Adult Eye    65.075 Adult Brain    58.1 Adult Thoracic-Abdominal Ganglion    97.4 Adult Crop    169.4 Adult Midgut    268.7 Adult Hindgut    227 Adult Malpighian Tubules    819.9 Adult Fat Body    828.5 Adult Salivary Gland    225.7 Adult Heart    379.55 Adult VirginFemale Spermatheca    1292.7 Adult InseminatedFemale Spermatheca    1070.7 Adult Ovary    3.5 Adult Testis    8.5 Adult Male Accessory Gland    237.3 Adult Carcass    294.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    174.3   NA  Eye    65.075   NA  Brain    58.1   15.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    97.4   NA  Crop    169.4   387.7  Midgut    268.7   92.6  Hindgut    227   21.8  Malpighian Tubules    819.9   33.3  Fat Body    828.5   no informative data  Salivary Gland    225.7   NA  Heart    379.55   14.275  Trachea    NA   NA  VirginFemale Spermatheca    1292.7   NA  InseminatedFemale Spermatheca    1070.7   NA  Ovary    3.5   NA  Testis    8.5   NA  Male Accessory Gland    237.3   27.35  Carcass    294.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  (34) head, virgin 4-day female    22 head, virgin 20-day female  (37) head, mated 1-day female    24 head, mated 4-day female  (55) head, mated 20-day female  (34) head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult  (61) digestive system, 4-day adult  (51) digestive system, 20-day adult  (43) fat body, larvae L3 wandering  (32) fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult  (36) carcass, 4-day adult  (41) carcass, 20-day adult  (35) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  (34) head, virgin 4-day female    22 head, virgin 20-day female  (37) head, mated 1-day female    24 head, mated 4-day female  (55) head, mated 20-day female  (34) head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult  (61) digestive system, 4-day adult  (51) digestive system, 20-day adult  (43) fat body, larvae L3 wandering  32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult  (36) carcass, 4-day adult  (41) carcass, 20-day adult  (35) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    34 head, virgin 4-day female    22 head, virgin 20-day female    37 head, mated 1-day female    24 head, mated 4-day female    55 head, mated 20-day female    34 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    21 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    61 digestive system, 4-day adult    51 digestive system, 20-day adult    43 fat body, larvae L3 wandering    32 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    1 carcass, 1-day adult    36 carcass, 4-day adult    41 carcass, 20-day adult    35 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    108 embryo 20-22hr    124 embryo 22-24hr    105 larva L1    142 larva L2    75 larva L3 12hr old    146 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr  (32) embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr  (44) embryo 18-20hr  (108) embryo 20-22hr  (124) embryo 22-24hr  (105) larva L1  (142) larva L2  (75) larva L3 12hr old  (146) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP  26 adult male 01day  26 adult male 05day    18 adult male 30day    16 adult female 01day  26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr  (108) embryo 20-22hr  (124) embryo 22-24hr  105 larva L1  (142) larva L2    75 larva L3 12hr old  (146) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    108 embryo 20-22hr    124 embryo 22-24hr    105 larva L1    142 larva L2    75 larva L3 12hr old    146 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    108 embryo 20-22hr    124 embryo 22-24hr    105 larva L1    142 larva L2    75 larva L3 12hr old    146 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr  32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr  (44) embryo 18-20hr  (108) embryo 20-22hr  (124) embryo 22-24hr  (105) larva L1  (142) larva L2  (75) larva L3 12hr old  (146) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP  26 adult male 01day  26 adult male 05day    18 adult male 30day    16 adult female 01day  26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr  108 embryo 20-22hr  124 embryo 22-24hr  105 larva L1  142 larva L2    75 larva L3 12hr old  (146) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    32 embryo 08-10hr    25 embryo 10-12hr    22 embryo 12-14hr    12 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    108 embryo 20-22hr    124 embryo 22-24hr    105 larva L1    142 larva L2    75 larva L3 12hr old    146 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    18 adult male 30day    16 adult female 01day    26 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    149 embryonic 1182-4H    197 embryonic GM2    378 embryonic Kc167    12 embryonic S1    21 embryonic S3    137 leg disc CME L1    129 wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21    118 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4  (149) embryonic 1182-4H  (197) embryonic GM2  (378) embryonic Kc167    12 embryonic S1    21 embryonic S3  (137) leg disc CME L1  (129) wing disc CME-W2  (95) wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  (62) wing disc ML-DmD21  (118) wing disc ML-DmD32  (69) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (71) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (58) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4  (149) embryonic 1182-4H  (197) embryonic GM2  (378) embryonic Kc167    12 embryonic S1    21 embryonic S3  (137) leg disc CME L1  (129) wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21  (118) wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    149 embryonic 1182-4H    197 embryonic GM2    378 embryonic Kc167    12 embryonic S1    21 embryonic S3    137 leg disc CME L1    129 wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21    118 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    149 embryonic 1182-4H    197 embryonic GM2    378 embryonic Kc167    12 embryonic S1    21 embryonic S3    137 leg disc CME L1    129 wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21    118 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4  (149) embryonic 1182-4H  (197) embryonic GM2  (378) embryonic Kc167    12 embryonic S1    21 embryonic S3  (137) leg disc CME L1  (129) wing disc CME-W2  (95) wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  (62) wing disc ML-DmD21  (118) wing disc ML-DmD32  (69) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (71) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (58) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4  (149) embryonic 1182-4H  (197) embryonic GM2  (378) embryonic Kc167    12 embryonic S1    21 embryonic S3  137 leg disc CME L1  129 wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21  118 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    149 embryonic 1182-4H    197 embryonic GM2    378 embryonic Kc167    12 embryonic S1    21 embryonic S3    137 leg disc CME L1    129 wing disc CME-W2    95 wing disc ML-DmD8    0 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    62 wing disc ML-DmD21    118 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    58 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (40) Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3  (30) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (92) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (40) Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3  30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (92) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    40 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086450 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2194-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable su(r)C4 su(r)C5 su(r)C11 su(r)C43 su(r)f04505 viable, with Scer\GAL4pnr-MD237 su(r)GD8891 Sterility Allele fertile su(r)C4 su(r)C5 su(r)C11 su(r)C43 su(r)f04505 Other Phenotypes Allele chemical sensitive su(r)1 su(r)C11 Phenotype manifest in Allele
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of su(r) Class Mutagen Stocks Known lesion su(r)f04505 piggyBac transposase 2 -- su(r)1 ethyl methanesulfonate 1 Yes su(r)C11 Delta2-3 1 Yes su(r)10 0 -- su(r)2 0 -- su(r)3 0 -- su(r)4 0 -- su(r)5 0 -- su(r)6 0 -- su(r)7 0 -- su(r)8 0 -- su(r)9 0 -- su(r)C43 Delta2-3 0 Yes su(r)C4 Delta2-3 0 Yes su(r)C5 Delta2-3 0 Yes su(r)unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of su(r) Class Mutagen Stocks Known lesion su(r)+t7.3 in vitro construct - genomic fragment 1 Yes su(r)GD8891 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(r)KK108027 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(r)NIG.2194R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8891} NA P{KK108027} NA P{NIG.2194R} NA characterization construct P{PYD1+} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}su(r)f04505 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
'de novo' pyrimidine nucleobase biosynthetic process inferred from genetic interaction with r (Rawls, 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
dihydroorotate oxidase activity inferred from electronic annotation with InterPro:IPR005720 (FlyBase Curators et al., 2004-) dihydropyrimidine dehydrogenase (NADP+) activity inferred from sequence or structural similarity with NCBI_gi:4503373 (FlyBase, 1992-) non-traceable author statement (Gojkovic, 2002.9.10) dihydrouracil dehydrogenase (NAD+) activity traceable author statement (Lindsley and Zimm, 1992) electron carrier activity inferred from electronic annotation with InterPro:IPR001450, InterPro:IPR017900 (FlyBase Curators et al., 2004-) iron-sulfur cluster binding inferred from electronic annotation with InterPro:IPR001450, InterPro:IPR009051, InterPro:IPR012285, InterPro:IPR017896, InterPro:IPR017900 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001295, InterPro:IPR005720, InterPro:IPR012135, InterPro:IPR012285 (FlyBase Curators et al., 2004-) UMP biosynthetic process inferred from electronic annotation with InterPro:IPR012135 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR005720 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions su(r) allele Gene References su(r)1 r (Bahn, 1972) unspecified r (Rawls, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58311 DroID - A comprehensive database of gene and protein interactions. • FBgn0086450 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31858
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QC1QP Dipteran inclusive ortholog search EOG608NH1 Insect inclusive ortholog search EOG6ZCS0C Arthropod inclusive ortholog search EOG67SQVP Metazoa inclusive ortholog search EOG6P06M0
Orthologs in Drosophila Species (EOG6QC1QP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\su(r)     Drosophila simulans   Dsim\GD16077     Drosophila sechellia   Dsec\GM13670     Drosophila erecta   Dere\GG18994     Drosophila yakuba   Dyak\GE17405     Drosophila ananassae   Dana\GF19101     Drosophila pseudoobscura pseudoobscura   Dpse\GA15293     Drosophila persimilis   Dper\GL26798     Drosophila willistoni   Dwil\GK25544     Drosophila virilis   Dvir\GJ18897     Drosophila mojavensis   Dmoj\GI15089     Drosophila grimshawi   Dgri\GH17755
Orthologs in non-Drosophila Dipterans (EOG608NH1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017154   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014199   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010204   Anopheles gambiae Malaria mosquito  Agam\AGAP001021   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005573
Orthologs in non-Dipteran Insects (EOG6ZCS0C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410207   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003258   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22363   Atta cephalotes Leafcutter ant  Acep\ACEP27915   Atta cephalotes Leafcutter ant  Acep\ACEP27912   Atta cephalotes Leafcutter ant  Acep\ACEP27913   Atta cephalotes Leafcutter ant  Acep\ACEP27916   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18749   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18748   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23112   Linepithema humile Argentine ant  Lhum\LH15195   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11266   Solenopsis invicta Red fire ant  Sinv\SINV21319   Solenopsis invicta Red fire ant  Sinv\SINV21284   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004747   Bombyx mori Silkmoth  Bmor\BGIBMGA007111   Pediculus humanus Human body louse  Phum\PHUM424200   Tribolium castaneum Red flour beetle  Tcas\TC010364
Orthologs in non-Insect Arthropods (EOG67SQVP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_202177   Ixodes scapularis Deer tick  Isca\ISCW022746
Orthologs in non-Arthropod Metazoa (EOG6P06M0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dpyd-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000800gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000799gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027398gn   Danio rerio Zebrafish  Drer\CR855273.1   Danio rerio Zebrafish  Drer\dpyd   Danio rerio Zebrafish  Drer\ENSDARG00000086464   Danio rerio Zebrafish  Drer\zgc:153505   Danio rerio Zebrafish  Drer\ENSDARG00000086853   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000008600   Gallus gallus Domestic chicken  Ggal\DPYD   Mus musculus House mouse  Mmus\Dpyd   Rattus norvegicus Norway rat  Rnor\Dpyd   Homo sapiens Human  Hsap\ENSG00000188641
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000188641
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	24478 w*; P{PYD1+}2 5882 su(r)1 rC; b1 18778 w1118 PBac{WH}su(r)f04505 24476 y1 w* su(r)C11 rC/FM0; b1
Harvard	- PBac{WH}su(r)f04505
VDRC	v100560 P{KK108027}VIE-260B v19279 w1118 P{GD8891}v19279
Genomic Clones ( 2 )
	BACR30C13 BACR39L04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01650 GH13260
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12280 AT15190 AT17330 AT18886 AT28765 AT30724 GH13324 GH13737 GH15525 GH17338 GH19484 GH25023 GH28640 GM24990 LD30322 RE11375 RE13574 RE30851 RE33826 RE38439 RE38539 RE40973 RE41518 RE56628 RE69332 RE72953 RH01845 RH02412 RH22359 RH22793 RH26355 RH28370 RH35063 RH52896 RH66664 RH67851 RH74371 SD03670 SD05276 SD11311 SD14821 SD19640 SD23602 SD26486 SD27826 SD27994
Other clones	16033 28933 34321 44943 105260 162984 542695 EK126450 EK137728 EK149320 EK160914 EK267417 EN11130 IP14905 RP004037712 RP004179751 RP004196562 RP004214725 RP004217992 RP004230193 RP004230895 RP004363653 RP004456877 RP004468614 RP004495490 RP004514555 RP004537989 RP004544976 RP004549451
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086450 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31858
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Reg-3 CG2194 (Nusskern, 1999.11)
Source for database merge of	Source for merge of: su(r) Reg-3 (Rawls, 2006)
Additional comments
Other Comments
	Isolated as a rhythmically expressed transcript in fly heads. Transcript shows a single daily peak and a single daily trough in expression, highest expression is in the 'morning'. Reg-3 expression oscillation is dependent on a light-dark cycle, on timed feeding and on the function of the per gene. (van Gelder et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167182 RefSeq (Proteins) • NP_727320 DDBJ / EMBL / GenBank • AAC47288 AAF46461 AAL13488 AAN09247 AAN64918 AAY44826 AF545061 AI062444 AW940058 AY058259 CZ487041 DQ027826 DQ257368 DQ257369 DQ257370 DQ257371 U65491 Entrez Gene - A searchable database of RefSeq genes. • 31858 UniProtKB/TrEMBL • Q4TWT4 Q9W374 Q95U76 Q94914
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dihydroorotate dehydrogenase, class 1/ 2 (IPR012135) Dihydroorotate dehydrogenase, conserved site (IPR001295) Dihydroorotate dehydrogenase domain (IPR005720) Alpha-helical ferredoxin (IPR009051) Fumarate reductase, C-terminal (IPR012285) Aldolase-type TIM barrel (IPR013785) 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896) 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900) 4Fe-4S binding domain (IPR001450)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58311 DroID - A comprehensive database of gene and protein interactions. • FBgn0086450 DRSC - Results from RNAi screens. • FBgn0086450 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086450 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2194-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086450 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31858 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31858 modMine - Data generated by the modENCODE project. • FBgn0086450
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG2194 (Rawls, 2006, Keleman et al., 2009.8.5) Dreg-3 (Nara et al., 2000, Van Gelder, 1996.7.29, van Gelder and Krasnow, 1996, van Gelder et al., 1995) Pyd1 (Gojkovic, 2002.9.10) pyd1 (Borycz et al., 2012) Reg-3 (Altenhein et al., 2006, Gruenewald et al., 2009, Lawniczak and Begun, 2004) su(r) (Rawls, 2006, Wright, 1987, Japanese National Institute of Genetics, 2012.5.21, Borycz et al., 2012)
Name Synonym	Drosophila Rhythmically expressed gene 3 (van Gelder and Krasnow, 1996, van Gelder et al., 1995) Rhythmically expressed gene 3   suppressor of rudimentary (Wright, 1987, Borycz et al., 2012)
Secondary FlyBase IDs
	FBgn0003574 FBgn0016718
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Book  ( 1 )
Recent research papers ( 1 )
	Borycz et al., 2012, J. Exp. Biol. 215(8): 1399--1411 The metabolism of histamine in the Drosophila optic lobe involves an ommatidial pathway: β-alanine recycles through the retina. [FBrf0217847] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...