FB2021_02, released April 13, 2021

Gene: Dmel\jing

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General Information
Symbol
Dmel\jing
Species
D. melanogaster
Name
jing
Annotation Symbol
CG9397
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086655
Gene Model Status
Current
Stock Availability
44 publicly available
Gene Summary
May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary. (UniProt, Q7KHG2)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

1.28, l(2)01094, l(2)22F3, rhumba

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:6,502,006..6,621,792 [+]
Recombination map
2-55
RefSeq locus
NT_033778 REGION:6502006..6621792
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (13 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Sun et al., 2006)
involved_in border follicle cell migration
inferred from mutant phenotype
(Liu and Montell, 2001)
involved_in central nervous system development
inferred from mutant phenotype
(Sedaghat and Sonnenfeld, 2002, Sedaghat et al., 2002)
involved_in glial cell migration
inferred from mutant phenotype
(Sun et al., 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Culi et al., 2006)
involved_in leg disc proximal/distal pattern formation
inferred from mutant phenotype
(Culi et al., 2006)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Culi et al., 2006)
involved_in open tracheal system development
inferred from mutant phenotype
(Sedaghat et al., 2002)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Sonnenfeld et al., 2010)
involved_in specification of segmental identity, maxillary segment
inferred from expression pattern
(Mahaffey et al., 1993)
inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439
(Mahaffey et al., 1993)
involved_in tissue regeneration
inferred from mutant phenotype
(assigned by UniProt )
(McClure and Schubiger, 2008)
involved_in ventral midline development
inferred from mutant phenotype
(assigned by UniProt )
(Sonnenfeld et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002323211
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from direct assay
(Herz et al., 2012)
located_in nucleus
inferred from direct assay
(Liu and Montell, 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from biological aspect of ancestor with PANTHER:PTN002323211
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from sequence or structural similarity with FLYBASE:ci; FB:FBgn0004859
(Liu and Montell, 2001)
inferred from sequence or structural similarity with MGI:MGI:1338038
(Liu and Montell, 2001)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the AEBP2/jing C2H2-type zinc-finger family. (Q7KHG2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary.
(UniProt, Q7KHG2)
Summary (Interactive Fly)

zinc finger transcription factor - a downstream target of required for border cell migration - also plays an essential role in controlling CNS midline and tracheal cell differentiation

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\jing for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
jing-RD
FBtr0301636
NM_206027
4817
1486
jing-RH
FBtr0114364
NM_001103729
5126
1486
jing-RI
FBtr0114365
NM_001103730
6397
1744
jing-RJ
FBtr0332950
NM_136371
7491
1471
Additional Transcript Data and Comments
Reported size (kB)

2.1 (northern blot)

(Mahaffey et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
jing-PD
FBpp0290850
155.3
1486
9.83
NP_995749
AAS64777
jing-PH
FBpp0112913
155.3
1486
9.83
NP_001097199
AAM68380
jing-PI
FBpp0112914
181.2
1744
9.97
NP_001097200
ABV53707
jing-PJ
FBpp0305167
153.4
1471
9.55
NP_610215
AAF57358
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1486 aa isoforms: jing-PD, jing-PH
Additional Polypeptide Data and Comments
Reported size (kDa)

217 (aa); 22 (kD predicted)

(Mahaffey et al., 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jing using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
supraesophageal ganglion
(Sedaghat et al., 2002)
embryonic stage 9 -- 15
ventral midline of embryo
(Sedaghat et al., 2002)
ventral neurectoderm | segmentally repeated
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium | anterior
(Sedaghat et al., 2002)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hindgut
(Mahaffey et al., 1993)
embryonic/larval anterior midgut
(Mahaffey et al., 1993)
embryonic prothoracic segment | restricted
(Mahaffey et al., 1993)
embryonic abdominal segment 8 | restricted
(Mahaffey et al., 1993)
embryonic/larval posterior midgut
(Mahaffey et al., 1993)
epidermis of embryonic maxillary segment
(Mahaffey et al., 1993)
proctodeum
(Mahaffey et al., 1993)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9
supraesophageal ganglion
(Sedaghat et al., 2002)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 15
ventral midline of embryo
(Sedaghat et al., 2002)
ventral neurectoderm | segmentally repeated
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium | anterior
(Sedaghat et al., 2002)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
midline glial cell
(Kearney et al., 2004)
adult stage
adult mushroom body | restricted
(Kobayashi et al., 2006)
Additional Descriptive Data

jing transcripts are first detected in stage 11 embryos in the proctodeum and in within a cluster of cells in the posterior-lateral portion of the eighth abdominal segment. Transcripts also accumulate in the hindgut and in the developing anterior and posterior midguts. After germ band contraction, transcripts accumulate within a few cells along the posterior-mid-lateral edge of the prothoracic segment. In the maxillary lobe, expression is limited to the posterior-lateral epidermis of the lobe and is first detected in stage 12.

(Mahaffey et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 14
ventral midline of embryo
• nucleus
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium
• nucleus
(Sedaghat et al., 2002)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from direct assay
(Herz et al., 2012)
located_in nucleus
inferred from direct assay
(Liu and Montell, 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\jing in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 71 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of jing
Transgenic constructs containing regulatory region of jing
Aberrations (Deficiencies and Duplications) ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable (with Df(2R)BSC326)
Other Phenotypes
Allele
abnormal locomotor behavior, with Scer\GAL4Appl.G1a
abnormal locomotor behavior, with Scer\GAL4elav.PLu
abnormal locomotor behavior, with Scer\GAL4nrv2.PS
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4sim.P3.7
abnormal neuroanatomy, with Scer\GAL4sli.PS
abnormal neuroanatomy (with Df(2R)ST1)
decreased cell death, with Scer\GAL4sli.PS
increased cell death
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4tsh-md621
visible | somatic clone
wild-type
Phenotype manifest in
Allele
abdomen | somatic clone
alula | somatic clone
border follicle cell | somatic clone
commissure & growth cone
dMP2 neuron
dorsal trunk primordium
dorsal trunk primordium, with Scer\GAL4btl.PS
dorsal trunk primordium | embryonic stage 13
dorsal trunk primordium | embryonic stage 15
embryonic/larval dorsal branch, with Scer\GAL4btl.PS
embryonic/larval dorsal branch | embryonic stage 13
embryonic/larval dorsal branch | embryonic stage 15
embryonic/larval dorsal trunk (with Df(2R)ST1)
embryonic/larval ganglionic branch | embryonic stage 15
embryonic/larval ganglionic branch | embryonic stage 15, with Scer\GAL4btl.PS
embryonic/larval glial cell
embryonic/larval glial cell (with Df(2R)ST1)
embryonic/larval neuron
embryonic/larval trachea, with Scer\GAL4arm.PS
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic brain
embryonic brain, with Scer\GAL4sim.P3.7
eye, with Scer\GAL4GMR.PF
femur & bract | somatic clone
femur | somatic clone
interface glial cell
interface glial cell (with Df(2R)ST1)
interommatidial bristle, with Scer\GAL4GMR.PF
larval anterior commissure, with Scer\GAL4elav.PLu
larval longitudinal connective
larval longitudinal connective, with Scer\GAL4elav.PLu
larval longitudinal connective, with Scer\GAL4sim.P3.7
larval longitudinal connective (with Df(2R)ST1)
larval posterior commissure, with Scer\GAL4elav.PLu
larval ventral nerve cord commissure, with Scer\GAL4sli.PS
lateral trunk anterior branch | embryonic stage 15
lateral trunk anterior branch | embryonic stage 15, with Scer\GAL4btl.PS
lateral trunk posterior branch | embryonic stage 15
lateral trunk posterior branch | embryonic stage 15, with Scer\GAL4btl.PS
leg | somatic clone
metatarsus | somatic clone
midline glial cell
midline ventral glial cell
midline ventral glial cell (with Df(2R)ST1)
midline ventral glial cell | ectopic, with Scer\GAL4sli.PS
MP1 neuron
neuroblast MNB
ommatidium, with Scer\GAL4GMR.PF
presumptive embryonic/larval tracheal system
symmetrical commissure
symmetrical commissure, with Scer\GAL4sim.P3.7
tibia | somatic clone
tracheal metamere | embryonic stage 15
tracheal metamere | embryonic stage 15, with Scer\GAL4btl.PS
transverse connective primordium
transverse connective primordium, with Scer\GAL4btl.PS
ventral midline of embryo
visceral branch
visceral branch, with Scer\GAL4btl.PS
vMP2 neuron
VUM neuron
wing margin bristle | somatic clone
wing vein | cell autonomous | somatic clone
wing vein | cell non-autonomous | somatic clone
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | ectopic | somatic clone
wing vein | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AEBP2
6 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aebp2
6 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Aebp2
4 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\aebp2
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\aebp2
6 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901S4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005573
Drosophila simulans
Dsim\GD10410
Drosophila sechellia
Dsec\GM20879
Drosophila erecta
Dere\GG23205
Drosophila yakuba
Dyak\GE19060
Drosophila ananassae
Dana\GF11054
Drosophila pseudoobscura pseudoobscura
Dpse\GA30272
Drosophila persimilis
Dper\GL20348
Drosophila willistoni
Dwil\GK19503
Drosophila virilis
Dvir\GJ21455
Drosophila mojavensis
Dmoj\GI18378
Drosophila grimshawi
Dgri\GH22893
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503QZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020362
Glossina morsitans
Tsetse fly
Gmor\GMOY003608
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00748
Mayetiola destructor
Hessian fly
Mdes\Mdes007520
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000263
Anopheles darlingi
American malaria mosquito
Adar\ADAC005785
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011015
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03J5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000848
Danaus plexippus
Monarch butterfly
Dple\DPOGS202650-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007954
Apis florea
Little honeybee
Aflo\2147508707
Apis mellifera
Western honey bee
Amel\GB55576
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20489
Bombus terrestris
Buff-tailed bumblebee
Bter\15203388
Linepithema humile
Argentine ant
Lhum\LH18405
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000adf
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009411
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04427
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11983
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07760
Pediculus humanus
Human body louse
Phum\PHUM503230
Rhodnius prolixus
Kissing bug
Rpro\RPRC003282
Cimex lectularius
Bed bug
Clec\CLEC009587
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI36131
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10039
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03FU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60562.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60563.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68660.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g12270
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g12230
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_56446
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0594 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z258
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021947gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_014141gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Krl
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003436
Gallus gallus
Domestic chicken
Ggal\AEBP2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AEBP2; AE binding protein 2
    6 of 15
    617934
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        jing
        suppressible
        Egfr
        (Sonnenfeld et al., 2004)
        jing
        suppressible
        Ras85D
        (Sonnenfeld et al., 2004)
        jing
        suppressible
        S
        (Sonnenfeld et al., 2004)
        jing
        enhanceable
        sim
        (Sedaghat et al., 2002)
        jing
        enhanceable
        sli
        (Sedaghat et al., 2002)
        jing
        suppressible
        spi
        (Sonnenfeld et al., 2004)
        sim|jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        trh|jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        jing
        enhanceable
        XNP
        (Sun et al., 2006)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        hng1
        suppressible
        jing
        (Shukla et al., 2014)
        hng1
        enhanceable
        jing
        (Shukla et al., 2014)
        hth
        enhanceable
        jing
        (Culi et al., 2006)
        kay
        enhanceable
        jing
        (Sun et al., 2006)
        lap
        enhanceable
        jing
        (Sun et al., 2006)
        pbl
        suppressible
        jing
        (Gregory et al., 2007)
        Pc
        enhanceable
        jing
        (Culi et al., 2006)
        sim
        enhanceable
        jing
        (Sedaghat et al., 2002)
        slbo
        suppressible
        jing
        (Liu and Montell, 2001)
        trh
        enhanceable
        jing
        (Sedaghat et al., 2002)
        wg
        suppressible
        jing
        (McClure and Schubiger, 2008)
        XNP
        enhanceable
        jing
        (Sun et al., 2006)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        42B1-42B2
        Sequence location
        2R:6,502,006..6,621,792 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        42B1-42B2
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        42B2-42B2
        (Sonnenfeld, 2000.7.7)
        42B-42B
        (Liu, 2000.3.10, Mahaffey, 1992)
        42B1-42B3
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        42B3-42C7
        (determined by deficiency mapping, details unspecified).
        (Liu and Montell, 1999)
        42B1-42B3
        42B2--3
        (BDGP Project Members, 1994-1999)
        42B-42B
        (determined by in situ hybridisation)
        (Mahaffey et al., 1993)
        Experimentally Determined Recombination Data
        Location

        2-55

        (FlyBase, 2016)

        2-55.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (44)
        Genomic Clones (64)
        cDNA Clones (65)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Nair et al., 2013, Sedaghat et al., 2002)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: jing l(2)22F3 l(2)01094 rhumba

        (Liu and Montell, 2001)

        Source for merge of: jing 1.28

        (Culi et al., 2006)
        Additional comments

        "1.28" may correspond to "Scim21". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim21" near/in "1.28".

        (Dobie and Karpen, 2001.4.18)
        Other Comments

        Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

        (Tay and Pek, 2017)

        The jing and Egfr pathways are functionally related in the embryonic central nervous system midline and trachea.

        (Sonnenfeld et al., 2004)

        jing is required for embryonic brain development.

        (Sedaghat and Sonnenfeld, 2002)

        jing is a mediator of cellular differentiation in the central nervous system and tracheal system.

        (Sedaghat et al., 2002)

        jing is required for the initiation of border cell migration.

        (Liu and Montell, 2001)

        jing is required for the transition of border cells from a stationary state to a motile state during oogenesis. jing appears to act downstream of slbo.

        (Liu and Montell, 2000)

        Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

        (Roch et al., 1998)

        The 1.28 gene is directly activated by Dfd in the maxillary segment but not in the mandibular segment. Four Dfd-product binding sites have been identified within a 664bp fragment of the 1.28 regulatory region, in addition to a Dfd epidermal autoactivation element (DEAE).

        (Pederson and Mahaffey, 1995)

        Identified in an enhancer trap screen for target genes of homeoproteins. The 1.28 gene is a target gene that is activated by Dfd. Dfd is required to activate 1.28 in the maxillary segment, but ectopic expression of Dfd is incapable of activating 1.28 elsewhere.

        (Mahaffey et al., 1993)
        Origin and Etymology
        Discoverer
        Etymology

        The gene is named "jing" (meaning "still") as it is required for the transition of border cells from a stationary state to a motile state.

        (Liu and Montell, 2000)
        Identification
        External Crossreferences and Linkouts ( 60 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Reported As
        Symbol Synonym
        1.28
        (Gistelinck et al., 2012, Blard et al., 2007, Buszczak et al., 2007, Gregory et al., 2007, Reiter et al., 2007, Sambandan et al., 2006, Pearson et al., 2005)
        AEBP2
        (Margueron and Reinberg, 2011)
        CG9397
        (Meadows, 2018.10.31, Fukuoh et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Dobie and Karpen, 2001.4.18, Mount, 2001.8.14)
        CG9403
        (Perkins et al., 2009.3.31, Quinones-Coello, 2007, Bessa et al., 2002, Brody et al., 2002, Levis, 2002.12.17, Liu and Montell, 2001)
        CT9093
        (Ceriani et al., 2002)
        Jing
        (Chetverina et al., 2020, DeLuca et al., 2020, Herz et al., 2012)
        jing
        (Chaouch and Lasko, 2021, Berlandi et al., 2019, Hall et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Levis, 2018.8.30, Ma et al., 2018, Fochler et al., 2017, Tay and Pek, 2017, Transgenic RNAi Project members, 2017-, Yadav et al., 2017, Clandinin and Owens, 2016-, Hunter et al., 2016, Ma et al., 2016, de Taffin et al., 2015, Duff et al., 2015, Kang et al., 2015, Morgante et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Dunne et al., 2014, Fedotov et al., 2014, Jalvingh et al., 2014, Rogers et al., 2014, Shukla et al., 2014, Vernes, 2014, Lavagnino et al., 2013, Nair et al., 2013, Sen et al., 2013, Webber et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mackay et al., 2012, Smibert et al., 2012, Spokony and White, 2012.5.22, Carreira et al., 2011, Grimberg et al., 2011, Morozova et al., 2010, Reis et al., 2010, Sonnenfeld et al., 2010, Klattenhoff et al., 2009, Southall and Brand, 2009, McClure and Schubiger, 2008, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Quinones-Coello, 2007, Culi et al., 2006, Kobayashi et al., 2006, Liebl et al., 2006, Otsuna and Ito, 2006, Sun et al., 2006)
        l(2)01094
        (Misra, 2000.8.25, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)
        l(2)22F3
        (Liu and Montell, 1999)
        Name Synonyms
        1.28
        Jing
        (Saadin and Starz-Gaiano, 2016)
        deformed
        (Mahaffey, 1992)
        jing
        (Xu et al., 2016, Dunne et al., 2014, Culi et al., 2006)
        rhumba
        (Sonnenfeld, 2000.7.7)
        Secondary FlyBase IDs
        • FBgn0041145
        • FBan0009403
        • FBgn0010347
        • FBgn0010475
        • FBgn0026656
        • FBgn0033077
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (150)