FlyBase Gene Report: Dmel\jing

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

UniProt Contributed Function Data

May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary.

(UniProt, Q7KHG2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\jing or the JBrowse view of Dmel\jing for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

jing-RD

FBtr0301636

NM_206027

4817

1486

jing-RH

FBtr0114364

NM_001103729

5126

1486

jing-RI

FBtr0114365

NM_001103730

6397

1744

jing-RJ

FBtr0332950

NM_136371

7491

1471

Additional Transcript Data and Comments

Reported size (kB)

2.1 (northern blot)

(Mahaffey et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

jing-PD

FBpp0290850

155.3

1486

9.83

NP_995749

AAS64777

jing-PH

FBpp0112913

155.3

1486

9.83

NP_001097199

AAM68380

jing-PI

FBpp0112914

181.2

1744

9.97

NP_001097200

ABV53707

jing-PJ

FBpp0305167

153.4

1471

9.55

NP_610215

AAF57358

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1486 aa isoforms: jing-PD, jing-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

217 (aa); 22 (kD predicted)

(Mahaffey et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jing using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (15 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nucleic acid binding

inferred from electronic annotation with InterPro:IPR013087

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (12 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

axon guidance

inferred from mutant phenotype

(Sun et al., 2006)

border follicle cell migration

inferred from mutant phenotype

(Liu and Montell, 2001)

central nervous system development

inferred from mutant phenotype

(Sedaghat and Sonnenfeld, 2002, Sedaghat et al., 2002)

glial cell migration

inferred from mutant phenotype

(Sun et al., 2006)

imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Culi et al., 2006)

leg disc proximal/distal pattern formation

inferred from mutant phenotype

(Culi et al., 2006)

negative regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Culi et al., 2006)

open tracheal system development

inferred from mutant phenotype

(Sedaghat et al., 2002)

positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Sonnenfeld et al., 2010)

specification of segmental identity, maxillary segment

inferred from expression pattern

(Mahaffey et al., 1993)

inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439

(Mahaffey et al., 1993)

tissue regeneration

inferred from mutant phenotype

(assigned by UniProt )

(McClure and Schubiger, 2008)

ventral midline development

inferred from mutant phenotype

(assigned by UniProt )

(Sonnenfeld et al., 2004)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

ESC/E(Z) complex

inferred from direct assay

(Herz et al., 2012)

nucleus

inferred from direct assay

(Liu and Montell, 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nucleus

inferred from sequence or structural similarity with FLYBASE:ci; FB:FBgn0004859

(Liu and Montell, 2001)

inferred from sequence or structural similarity with MGI:MGI:1338038

(Liu and Montell, 2001)

Expression Data

Transcript Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9

supraesophageal ganglion

(Sedaghat et al., 2002)

embryonic stage 9 -- 15

ventral midline

(Sedaghat et al., 2002)

ventral neurectoderm | segmentally repeated

(Sedaghat et al., 2002)

embryonic stage 10 -- 16

tracheal primordium | anterior

(Sedaghat et al., 2002)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval hindgut

(Mahaffey et al., 1993)

embryonic/larval anterior midgut

(Mahaffey et al., 1993)

embryonic prothoracic segment | restricted

(Mahaffey et al., 1993)

embryonic abdominal segment 8 | restricted

(Mahaffey et al., 1993)

embryonic/larval posterior midgut

(Mahaffey et al., 1993)

epidermis of embryonic maxillary segment

(Mahaffey et al., 1993)

proctodeum

(Mahaffey et al., 1993)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9

supraesophageal ganglion

(Sedaghat et al., 2002)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 15

ventral midline

(Sedaghat et al., 2002)

ventral neurectoderm | segmentally repeated

(Sedaghat et al., 2002)

embryonic stage 10 -- 16

tracheal primordium | anterior

(Sedaghat et al., 2002)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

adult stage

adult mushroom body | restricted

(Kobayashi et al., 2006)

Additional Descriptive Data

jing transcripts are first detected in stage 11 embryos in the proctodeum and in within a cluster of cells in the posterior-lateral portion of the eighth abdominal segment. Transcripts also accumulate in the hindgut and in the developing anterior and posterior midguts. After germ band contraction, transcripts accumulate within a few cells along the posterior-mid-lateral edge of the prothoracic segment. In the maxillary lobe, expression is limited to the posterior-lateral epidermis of the lobe and is first detected in stage 12.

(Mahaffey et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 14

ventral midline

• nucleus

(Sedaghat et al., 2002)

embryonic stage 10 -- 16

tracheal primordium

• nucleus

(Sedaghat et al., 2002)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

ESC/E(Z) complex

inferred from direct assay

(Herz et al., 2012)

nucleus

inferred from direct assay

(Liu and Montell, 2001)

Expression Deduced from Reporters

Reporter: P{HZ-4.0}

Stage

Tissue/Position (including subcellular localization)

Reference

late embryonic stage

embryonic maxillary segment

(Mahaffey et al., 1993)

Reporter: P{lacW}jing^P

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval anterior midgut

(Mahaffey et al., 1993)

embryonic/larval posterior midgut

(Mahaffey et al., 1993)

abdominal segment 8 | restricted

(Mahaffey et al., 1993)

proctodeum

(Mahaffey et al., 1993)

embryonic/larval hindgut

(Mahaffey et al., 1993)

prothoracic segment | restricted

(Mahaffey et al., 1993)

epidermis of embryonic maxillary segment

(Mahaffey et al., 1993)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\jing in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\jing

View exonic expression by tissue for Dmel\jing

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086655

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0086655

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9397-RA;CG9403-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9403

Flygut - An atlas of the Drosophila adult midgut

FBgn0086655

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\jing

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs and Phenotypes

Classical and Insertion Alleles ( 70 )

For All Classical and Insertion Alleles Show

Allele of jing

Class

Mutagen

Associated Insertion

Stocks

Known lesion

jing⁰¹⁰⁹⁴

P-element activity

P{PZ}jing⁰¹⁰⁹⁴

Yes

jing^k03404

P-element activity

P{lacW}jing^k03404

jing^k02002

P-element activity

P{lacW}jing^k02002

jing³

ethyl methanesulfonate

jing^k05311

P-element activity

P{lacW}jing^k05311

jing^k10314

P-element activity

P{lacW}jing^k10314

jing^k16705

P-element activity

P{lacW}jing^k16705

jing^22F3

ethyl methanesulfonate

Yes

jing^47H6

ethyl methanesulfonate

jing⁰⁷¹¹²

P-element activity

P{PZ}jing⁰⁷¹¹²

jing^k02102a

P-element activity

P{lacW}jing^k02102a

jing^rH623

P-element activity

P{PZ}jing^rH623

jing¹

ethyl methanesulfonate

Yes

jing^31E6

ethyl methanesulfonate

jing⁰⁷¹¹¹

P-element activity

P{PZ}jing⁰⁷¹¹¹

jing^k10323

P-element activity

P{lacW}jing^k10323

jing^KG01549

P{SUPor-P}jing^KG01549

Yes

Yes

Yes

piggyBac activity

PBac{IT.GAL4}jing^0837-G4

Yes

jing^1407-G4

piggyBac activity

PBac{IT.GAL4}jing^1407-G4

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

P{SUPor-P}jing^KG10537

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

ethyl methanesulfonate

jing³⁴⁹⁴

P-element activity

P{PdL}jing³⁴⁹⁴

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

P-element activity

P{lacW}jing^P

Yes

jing^rev

P-element activity

jing^rv13

Delta2-3 transposase

Yes

jing^unspecified

Other relevant insertions

insertion of mobile activating element

Name

Expression Data

P{EP}EP2189

miscellaneous insertions

Name

Expression Data

P{GT1}BG01686^BG01686

P{GT1}BG01803^BG01803

P{GT1}BG02314^BG02314

P{lacW}l(2)SH0335^SH0335

P{lacW}l(2)SH1846^SH1846

P{PTT-GB}CB04492

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of jing

Allele of jing

Mutagen

Associated Transgenic Construct

Stocks

jing^JF02345

P{TRiP.JF02345}

jing^UAS.cSa

in vitro construct - regulatory fusion

in vitro construct - regulatory fusion

P{UAS-jing.FL}

jing^{Znf.E1A.UAS.Tag:NLS(Unk),Tag:MYC}

P{UAS-jing.Znf.E1A}

jing^{Znf.EnR.UAS.Tag:NLS(Unk),Tag:MYC}

P{UAS-jing.Znf.EnR}

jing^{Znf.UAS.Tag:NLS(Unk),Tag:MYC}

P{UAS-jing.Znf}

jing^HMS01493

P{TRiP.HMS01493}

jing^{sfGFP,Tag:FLAG,Tag:CS(PSP),Tag:CS(TEVp),Tag:BLRP}

in vitro construct - coding region fusion

in vitro construct - regulatory fusion

in vitro construct - regulatory fusion

jing^{UAS.ORF.GW.Tag:HA}

M{UAS-jing.ORF.3xHA.GW}

jing^{Δ5N.Tag:polyHis}

P{UAS-jing.Δ5N.His6}

Transgenic constructs containing regulatory region of jing

reporter construct

Name

Expression Data

Yes

Deletions and Duplications ( 11 )

Summary of Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable (with Df(2R)BSC326)

jing^k03204

Other Phenotypes

Allele

decreased cell death, with Scer\GAL4^sli.PS

jing^UAS.cSa

increased cell death

jing³

locomotor behavior defective, with Scer\GAL4^Appl.G1a

jing^JF02345

locomotor behavior defective, with Scer\GAL4^elav.PLu

jing^JF02345

locomotor behavior defective, with Scer\GAL4^nrv2.PS

jing^JF02345

neuroanatomy defective

neuroanatomy defective, with Scer\GAL4^elav.PLu

neuroanatomy defective, with Scer\GAL4^sim.P3.7

jing^UAS.cSa

neuroanatomy defective, with Scer\GAL4^sli.PS

jing^UAS.cSa

neuroanatomy defective (with Df(2R)ST1)

jing³

visible, with Scer\GAL4^en-e16E

visible, with Scer\GAL4^GMR.PF

jing^UAS.cSa

visible, with Scer\GAL4^tsh-md621

jing^JF02345

visible | somatic clone

wild-type

jing^hs.PL

Phenotype manifest in

Allele

abdomen | somatic clone

alula | somatic clone

anterior commissure, with Scer\GAL4^elav.PLu

jing^UAS.cSa

border follicle cell | somatic clone

commissure

jing³

commissure, with Scer\GAL4^sim.P3.7

jing^UAS.cSa

commissure & growth cone

jing³

dMP2 neuron

jing³

dorsal trunk primordium

jing³

dorsal trunk primordium, with Scer\GAL4^btl.PS

jing^UAS.cSa

dorsal trunk primordium | embryonic stage 13

jing³

dorsal trunk primordium | embryonic stage 15

jing³

embryonic/larval dorsal branch, with Scer\GAL4^btl.PS

jing^UAS.cSa

embryonic/larval dorsal branch | embryonic stage 13

jing³

embryonic/larval dorsal branch | embryonic stage 15

jing³

embryonic/larval dorsal trunk (with Df(2R)ST1)

jing³

embryonic/larval ganglionic branch | embryonic stage 15

jing¹

embryonic/larval ganglionic branch | embryonic stage 15, with Scer\GAL4^btl.PS

jing^{dsRNA.UAS.WIZ}

embryonic/larval glial cell

embryonic/larval glial cell (with Df(2R)ST1)

jing³

embryonic/larval neuron

jing³

embryonic/larval trachea, with Scer\GAL4^arm.PS

jing^{Δ5N.Tag:polyHis}

embryonic/larval trachea, with Scer\GAL4^btl.PS

jing^{Δ5N.Tag:polyHis}

embryonic brain

jing³

embryonic brain, with Scer\GAL4^sim.P3.7

jing^UAS.cSa

eye, with Scer\GAL4^GMR.PF

jing^UAS.cSa

femur & bract | somatic clone

jing^22F3

femur | somatic clone

jing^unspecified

interface glial cell

jing^{dsRNA.UAS.WIZ}

interface glial cell (with Df(2R)ST1)

jing³

interommatidial bristle, with Scer\GAL4^GMR.PF

jing^UAS.cSa

lateral trunk anterior branch | embryonic stage 15

lateral trunk anterior branch | embryonic stage 15, with Scer\GAL4^btl.PS

jing^{dsRNA.UAS.WIZ}

lateral trunk posterior branch | embryonic stage 15

lateral trunk posterior branch | embryonic stage 15, with Scer\GAL4^btl.PS

jing^{dsRNA.UAS.WIZ}

leg | somatic clone

jing^22F3

longitudinal connective

jing³

longitudinal connective, with Scer\GAL4^elav.PLu

longitudinal connective, with Scer\GAL4^sim.P3.7

jing^UAS.cSa

longitudinal connective (with Df(2R)ST1)

jing³

metatarsus | somatic clone

jing^unspecified

midline glial cell

jing³

midline ventral glial cell

midline ventral glial cell (with Df(2R)ST1)

jing³

midline ventral glial cell | ectopic, with Scer\GAL4^sli.PS

jing^UAS.cSa

MP1 neuron

jing³

neuroblast MNB

jing³

ommatidium, with Scer\GAL4^GMR.PF

jing^UAS.cSa

posterior commissure, with Scer\GAL4^elav.PLu

jing^UAS.cSa

presumptive embryonic/larval tracheal system

jing³

tibia | somatic clone

jing^unspecified

tracheal metamere | embryonic stage 15

tracheal metamere | embryonic stage 15, with Scer\GAL4^btl.PS

jing^{dsRNA.UAS.WIZ}

transverse connective primordium

jing³

transverse connective primordium, with Scer\GAL4^btl.PS

jing^UAS.cSa

ventral midline

jing³

ventral nerve cord commissure, with Scer\GAL4^sli.PS

jing^UAS.cSa

visceral branch

jing³

visceral branch, with Scer\GAL4^btl.PS

jing^UAS.cSa

vMP2 neuron

jing³

VUM neuron

jing³

wing margin bristle | somatic clone

jing^unspecified

wing vein | cell autonomous | somatic clone

jing^22F3

wing vein | cell non-autonomous | somatic clone

jing^22F3

wing vein | ectopic, with Scer\GAL4^en-e16E

wing vein | ectopic | somatic clone

jing^22F3

wing vein | somatic clone

jing^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\AEBP2

6 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Aebp2

5 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Aebp2

4 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\aebp2

1 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\aebp2

6 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No orthologs reported.

Arabidopsis thaliana (thale-cress) (0)

No orthologs reported.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No orthologs reported.

Schizosaccharomyces pombe (Fission yeast) (0)

No orthologs reported.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901S4 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\jing

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA30272

Drosophila persimilis

Dper\GL20348

Drosophila willistoni

Dwil\GK19503

Drosophila virilis

Dvir\GJ21455

Drosophila mojavensis

Dmoj\GI18378

Drosophila grimshawi

Dgri\GH22893

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503QZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17020362

Glossina morsitans

Tsetse fly

Gmor\GMOY003608

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00748

Mayetiola destructor

Hessian fly

Mdes\Mdes007520

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL000263

Anopheles darlingi

American malaria mosquito

Adar\ADAC005785

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011015

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03J5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000848

Danaus plexippus

Monarch butterfly

Dple\DPOGS202650-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007954

Apis florea

Little honeybee

Aflo\2147508707

Apis mellifera

Western honey bee

Amel\GB55576

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20489

Bombus terrestris

Buff-tailed bumblebee

Bter\15203388

Linepithema humile

Argentine ant

Lhum\LH18405

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000adf

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009411

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04427

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11983

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07760

Pediculus humanus

Human body louse

Phum\PHUM503230

Rhodnius prolixus

Kissing bug

Rpro\RPRC003282

Cimex lectularius

Bed bug

Clec\CLEC009587

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI36131

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10039

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03FU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60562.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60563.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68660.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g12270

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g12230

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_56446

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0594 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Z258

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021947gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_014141gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Krl

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003436

Gallus gallus

Domestic chicken

Ggal\AEBP2

Human Disease Model Data

FlyBase Human Disease Model Reports

Alleles Reported to Model Human Disease (Disease Ontology)

Download

Models ( 0 )

Allele

Disease

Evidence

References

Interactions ( 0 )

Allele

Disease

Interaction

References

Comments ( 0 )

Human Orthologs (via DIOPT v7.1)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

Complementation?

Transgene?

AEBP2; AE binding protein 2

6 of 15

617934

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions

protein-protein

Interacting group

Assay

References

jing - E(z)

tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015)

jing - Jarid2

anti tag coimmunoprecipitation, multidimensional protein identification technology

(Herz et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

jing

suppressible

Egfr

(Sonnenfeld et al., 2004)

jing

suppressible

Ras85D

(Sonnenfeld et al., 2004)

jing

suppressible

(Sonnenfeld et al., 2004)

jing

enhanceable

sim

(Sedaghat et al., 2002)

jing

enhanceable

sli

(Sedaghat et al., 2002)

jing

suppressible

spi

(Sonnenfeld et al., 2004)

sim|jing

enhanceable

tgo

(Sedaghat et al., 2002)

jing

enhanceable

tgo

(Sedaghat et al., 2002)

trh|jing

enhanceable

tgo

(Sedaghat et al., 2002)

jing

enhanceable

XNP

(Sun et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hng1

suppressible

jing

(Shukla et al., 2014)

hng1

enhanceable

jing

(Shukla et al., 2014)

hth

enhanceable

jing

(Culi et al., 2006)

enhanceable

(Sun et al., 2006)

enhanceable

(Sun et al., 2006)

suppressible

(Gregory et al., 2007)

enhanceable

jing

(Culi et al., 2006)

sim

enhanceable

jing

(Sedaghat et al., 2002)

slbo

suppressible

jing

(Liu and Montell, 2001)

trh

enhanceable

jing

(Sedaghat et al., 2002)

suppressible

jing

(McClure and Schubiger, 2008)

XNP

enhanceable

jing

(Sun et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61456

DroID - A comprehensive database of gene and protein interactions.

FBgn0086655

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35555

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

PRC2 methylates histones and DNA

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42B1-42B2

Sequence location

2R:6,502,006..6,621,792 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42B1-42B2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

42B2-42B2

(Sonnenfeld, 2000.7.7)

42B-42B

(Liu, 2000.3.10, Mahaffey, 1992)

42B1-42B3

(determined by in situ hybridisation)

(Spradling et al., 1999)

42B3-42C7

(determined by deficiency mapping, details unspecified).

(Liu and Montell, 1999)

42B1-42B3

42B2--3

(BDGP Project Members, 1994-1999)

42B-42B

(determined by in situ hybridisation)

(Mahaffey et al., 1993)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (53)

d11151

d11284

c00429

c04920

c05964

e00429

e02223

e03962

f02133

f03328

f04824

f05645

More stocks available...

Genomic Clones (64)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (65)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

FI01114

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086655

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086655

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35555

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nair et al., 2013, Sedaghat et al., 2002)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: jing l(2)22F3 l(2)01094 rhumba

(Liu and Montell, 2001)

Source for merge of: jing 1.28

(Culi et al., 2006)

Additional comments

"1.28" may correspond to "Scim21". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim21" near/in "1.28".

(Dobie and Karpen, 2001.4.18)

Other Comments

Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

(Tay and Pek, 2017)

The jing and Egfr pathways are functionally related in the embryonic central nervous system midline and trachea.

(Sonnenfeld et al., 2004)

jing is required for embryonic brain development.

(Sedaghat and Sonnenfeld, 2002)

jing is a mediator of cellular differentiation in the central nervous system and tracheal system.

(Sedaghat et al., 2002)

jing is required for the initiation of border cell migration.

(Liu and Montell, 2001)

jing is required for the transition of border cells from a stationary state to a motile state during oogenesis. jing appears to act downstream of slbo.

(Liu and Montell, 2000)

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)

The 1.28 gene is directly activated by Dfd in the maxillary segment but not in the mandibular segment. Four Dfd-product binding sites have been identified within a 664bp fragment of the 1.28 regulatory region, in addition to a Dfd epidermal autoactivation element (DEAE).

(Pederson and Mahaffey, 1995)

Identified in an enhancer trap screen for target genes of homeoproteins. The 1.28 gene is a target gene that is activated by Dfd. Dfd is required to activate 1.28 in the maxillary segment, but ectopic expression of Dfd is incapable of activating 1.28 elsewhere.

(Mahaffey et al., 1993)

Origin and Etymology

Discoverer

Etymology

The gene is named "jing" (meaning "still") as it is required for the transition of border cells from a stationary state to a motile state.

(Liu and Montell, 2000)

Identification

External Crossreferences and Linkouts ( 57 )

Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35555

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KHG2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086655

InterPro - A database of protein families, domains and functional sites

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

PRC2 methylates histones and DNA

Linkouts

BioGRID - A database of protein and genetic interactions.

61456

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones

FBgn0086655

DroID - A comprehensive database of gene and protein interactions.

FBgn0086655

DRSC - Results frm RNAi screens

FBgn0086655

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0086655

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9397-RA;CG9403-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9403

Flygut - An atlas of the Drosophila adult midgut

FBgn0086655

FlyMine - An integrated database for Drosophila genomics

FBgn0086655

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35555

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007760

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35555

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9397

modMine - A data warehouse for the modENCODE project

FBgn0086655

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

1.28

(Gistelinck et al., 2012, Blard et al., 2007, Buszczak et al., 2007, Gregory et al., 2007, Reiter et al., 2007, Sambandan et al., 2006, Pearson et al., 2005)

AEBP2

(Margueron and Reinberg, 2011)

CG9397

(Fukuoh et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Dobie and Karpen, 2001.4.18, Mount, 2001.8.14)

CG9403

(Perkins et al., 2009.3.31, Quinones-Coello, 2007, Bessa et al., 2002, Brody et al., 2002, Levis, 2002.12.17, Liu and Montell, 2001)

CT9093

(Ceriani et al., 2002)

Jing

(Herz et al., 2012)

jing

(Levis, 2018.8.30, Ma et al., 2018, Fochler et al., 2017, Tay and Pek, 2017, Transgenic RNAi Project members, 2017-, Yadav et al., 2017, Clandinin and Owens, 2016-, Hunter et al., 2016, Ma et al., 2016, Duff et al., 2015, Kang et al., 2015, Morgante et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Dunne et al., 2014, Fedotov et al., 2014, Shukla et al., 2014, Vernes, 2014, Lavagnino et al., 2013, Nair et al., 2013, Sen et al., 2013, Webber et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mackay et al., 2012, Smibert et al., 2012, Spokony and White, 2012.5.22, Carreira et al., 2011, Grimberg et al., 2011, Morozova et al., 2010, Reis et al., 2010, Sonnenfeld et al., 2010, Klattenhoff et al., 2009, Southall and Brand, 2009, McClure and Schubiger, 2008, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Quinones-Coello, 2007, Culi et al., 2006, Kobayashi et al., 2006, Liebl et al., 2006, Otsuna and Ito, 2006, Sun et al., 2006)

l(2)01094

(Misra, 2000.8.25, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)

l(2)22F3

(Liu and Montell, 1999)

Name Synonyms

1.28

Jing

(Saadin and Starz-Gaiano, 2016)

deformed

(Mahaffey, 1992)

jing

(Xu et al., 2016, Dunne et al., 2014, Culi et al., 2006)

rhumba

(Sonnenfeld, 2000.7.7)

Secondary FlyBase IDs

FBgn0041145
FBan0009403
FBgn0010347
FBgn0010475
FBgn0026656
FBgn0033077

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (132)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections