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Gene Dmel\shrb

General Information
Symbol	Dmel\shrb	Species	D. melanogaster
Name	shrub	Annotation symbol	CG8055
Feature type	protein_coding_gene	FlyBase ID	FBgn0086656
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Vps32, vps32/snf7, ESCRT-III
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45A12-45E	Sequence location	2R:5,029,651..5,031,415 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene shrub is referred to in FlyBase by the symbol Dmel\shrb (CG8055, FBgn0086656). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; negative regulation of growth of symbiont in host. 12 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal multidendritic neuron ddaE; dorsal cluster neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: Snf7. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1638126_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of shrb. Gene sequence location is 2R:5029651..5031415.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA07061 BKN28557
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45A12-45E   Limits computationally determined from genome sequence between P{lacW}CG8788k04512&P{lacW}l(2)k13412k13412 and P{PZ}Pkn06736; Left limit from (method unavailable) (FBrf0112136) Right limit from (method unavailable) (FBrf0112136)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49C-50D   Determined by deficiency mapping (details unspecified).   (Gao et al., 1999) 44F-45E     (Gao et al., 1999) 44F-45E     (Gao, 1999.11.4)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\shrb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) shrb-RA FBtr0088623  NM_136618   1263   226
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein shrb-PA   FBpp0087704   25.4   226   4.42     NP_610462   AAF58977
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Snf7 (IPR005024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264253   AA951233   AE013599 AAF58977   AI106910   AI136001   AI513286   AI533379   AX094056   AY069131 AAL39276   BG635683   BG635684   BH840434   BI214045   BI231329   BI231564   BI237434   BI240896   BI568061   BI568137   BI572163   BI572164   BI573056   BI573452   BI573453   BI573739   BI573740   BI591104   BI591271   BI605576   BI607353   BI607654   BI608562   BI609447   BI616520   BI619674   BI620001   BI621752   BI625037   BI628741   BI630070   BI635495   BI641734   BP547005   BP547853   BQ103524   CA803181   CA807631   CK659364   CL610168   CO152978   CO194214   CO286085   CO304344   CO306395   CO314952   CO329330   CO337613   CO338212   CO338213   CO338605   CO338837   CZ472968   EC065862   EC202701   EC203354   EC207349   EC239334   EC262458   EC262643   EC263471   EC263520   EC266201   EC266258   EV598725
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T0Q4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086656    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086656 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086656 expression level Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3673) embryo 02-04hr  (2988) embryo 04-06hr  (3872) embryo 06-08hr  (4296) embryo 08-10hr  (4494) embryo 10-12hr  (3713) embryo 12-14hr  (3686) embryo 14-16hr  (1966) embryo 16-18hr  (2951) embryo 18-20hr  (3913) embryo 20-22hr  (3830) embryo 22-24hr  (5236) larva L1  (2399) larva L2  (2854) larva L3 12hr old  (2613) larva L3 puffstage 1-2  (4133) larva L3 puffstage 3-6  (5954) larva L3 puffstage 7-9  (7763) white prepupae new  (8011) white prepupae 12hr  (6175) white prepupae 24hr  (4972) pupae 2d postWPP  (3603) pupae 3d postWPP  (2655) pupae 4d postWPP  (2902) adult male 01day  (3667) adult male 05day  (3673) adult male 30day  (2930) adult female 01day  (2588) adult female 05day  (3711) adult female 30day  (3551) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3673) embryo 02-04hr  (2988) embryo 04-06hr  (3872) embryo 06-08hr  (4296) embryo 08-10hr  (4494) embryo 10-12hr  (3713) embryo 12-14hr  (3686) embryo 14-16hr  (1966) embryo 16-18hr  (2951) embryo 18-20hr  (3913) embryo 20-22hr  (3830) embryo 22-24hr  (5236) larva L1  (2399) larva L2  (2854) larva L3 12hr old  (2613) larva L3 puffstage 1-2  (4133) larva L3 puffstage 3-6  (5954) larva L3 puffstage 7-9  (7763) white prepupae new  (8011) white prepupae 12hr  (6175) white prepupae 24hr  (4972) pupae 2d postWPP  (3603) pupae 3d postWPP  (2655) pupae 4d postWPP  (2902) adult male 01day  (3667) adult male 05day  (3673) adult male 30day  (2930) adult female 01day  (2588) adult female 05day  (3711) adult female 30day  (3551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086656 expression level Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3673) embryo 02-04hr  (2988) embryo 04-06hr  (3872) embryo 06-08hr  (4296) embryo 08-10hr  (4494) embryo 10-12hr  (3713) embryo 12-14hr  (3686) embryo 14-16hr  (1966) embryo 16-18hr  (2951) embryo 18-20hr  (3913) embryo 20-22hr  (3830) embryo 22-24hr  (5236) larva L1  (2399) larva L2  (2854) larva L3 12hr old  (2613) larva L3 puffstage 1-2  (4133) larva L3 puffstage 3-6  (5954) larva L3 puffstage 7-9  (7763) white prepupae new  (8011) white prepupae 12hr  (6175) white prepupae 24hr  (4972) pupae 2d postWPP  (3603) pupae 3d postWPP  (2655) pupae 4d postWPP  (2902) adult male 01day  (3667) adult male 05day  (3673) adult male 30day  (2930) adult female 01day  (2588) adult female 05day  (3711) adult female 30day  (3551) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3673) embryo 02-04hr  (2988) embryo 04-06hr  (3872) embryo 06-08hr  (4296) embryo 08-10hr  (4494) embryo 10-12hr  (3713) embryo 12-14hr  (3686) embryo 14-16hr  1966 embryo 16-18hr  (2951) embryo 18-20hr  (3913) embryo 20-22hr  (3830) embryo 22-24hr  (5236) larva L1  2399 larva L2  (2854) larva L3 12hr old  (2613) larva L3 puffstage 1-2  (4133) larva L3 puffstage 3-6  (5954) larva L3 puffstage 7-9  (7763) white prepupae new  (8011) white prepupae 12hr  (6175) white prepupae 24hr  (4972) pupae 2d postWPP  (3603) pupae 3d postWPP  (2655) pupae 4d postWPP  (2902) adult male 01day  (3667) adult male 05day  (3673) adult male 30day  (2930) adult female 01day  (2588) adult female 05day  (3711) adult female 30day  (3551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3673 embryo 02-04hr    2988 embryo 04-06hr    3872 embryo 06-08hr    4296 embryo 08-10hr    4494 embryo 10-12hr    3713 embryo 12-14hr    3686 embryo 14-16hr    1966 embryo 16-18hr    2951 embryo 18-20hr    3913 embryo 20-22hr    3830 embryo 22-24hr    5236 larva L1    2399 larva L2    2854 larva L3 12hr old    2613 larva L3 puffstage 1-2    4133 larva L3 puffstage 3-6    5954 larva L3 puffstage 7-9    7763 white prepupae new    8011 white prepupae 12hr    6175 white prepupae 24hr    4972 pupae 2d postWPP    3603 pupae 3d postWPP    2655 pupae 4d postWPP    2902 adult male 01day    3667 adult male 05day    3673 adult male 30day    2930 adult female 01day    2588 adult female 05day    3711 adult female 30day    3551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086656    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086656 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086656 expression level Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut    1011.6 Larval Malpighian Tubules    1712.4 Larval Fat Body    1483.2 Larval Salivary Gland    964.7 Larval Trachea    1172.525 Larval Carcass    1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop    1307.7 Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules    1364.8 Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca    1147.6 Adult InseminatedFemale Spermatheca    1190.5 Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (778.075) Larval Midgut  (989.4) Larval Hindgut  (1011.6) Larval Malpighian Tubules  (1712.4) Larval Fat Body  (1483.2) Larval Salivary Gland  (964.7) Larval Trachea  (1172.525) Larval Carcass  (1015.025) Adult Head  (669.2) Adult Eye  (996.9) Adult Brain  (563) Adult Thoracic-Abdominal Ganglion  (722.9) Adult Crop  (1307.7) Adult Midgut  (835.2) Adult Hindgut  (912.3) Adult Malpighian Tubules  (1364.8) Adult Fat Body  (662.4) Adult Salivary Gland  (716.1) Adult Heart  (813.35) Adult VirginFemale Spermatheca  (1147.6) Adult InseminatedFemale Spermatheca  (1190.5) Adult Ovary  531 Adult Testis    268.4 Adult Male Accessory Gland  (967.9) Adult Carcass  (635.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut  1011.6 Larval Malpighian Tubules  (1712.4) Larval Fat Body  (1483.2) Larval Salivary Gland    964.7 Larval Trachea  (1172.525) Larval Carcass  1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop  (1307.7) Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules  (1364.8) Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca  (1147.6) Adult InseminatedFemale Spermatheca  (1190.5) Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut    1011.6 Larval Malpighian Tubules    1712.4 Larval Fat Body    1483.2 Larval Salivary Gland    964.7 Larval Trachea    1172.525 Larval Carcass    1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop    1307.7 Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules    1364.8 Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca    1147.6 Adult InseminatedFemale Spermatheca    1190.5 Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086656 expression level Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut    1011.6 Larval Malpighian Tubules    1712.4 Larval Fat Body    1483.2 Larval Salivary Gland    964.7 Larval Trachea    1172.525 Larval Carcass    1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop    1307.7 Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules    1364.8 Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca    1147.6 Adult InseminatedFemale Spermatheca    1190.5 Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  778.075 Larval Midgut  (989.4) Larval Hindgut  (1011.6) Larval Malpighian Tubules  (1712.4) Larval Fat Body  (1483.2) Larval Salivary Gland  (964.7) Larval Trachea  (1172.525) Larval Carcass  (1015.025) Adult Head  669.2 Adult Eye  (996.9) Adult Brain  563 Adult Thoracic-Abdominal Ganglion  722.9 Adult Crop  (1307.7) Adult Midgut  (835.2) Adult Hindgut  (912.3) Adult Malpighian Tubules  (1364.8) Adult Fat Body  662.4 Adult Salivary Gland  716.1 Adult Heart  813.35 Adult VirginFemale Spermatheca  (1147.6) Adult InseminatedFemale Spermatheca  (1190.5) Adult Ovary  531 Adult Testis    268.4 Adult Male Accessory Gland  (967.9) Adult Carcass  635.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut  1011.6 Larval Malpighian Tubules  1712.4 Larval Fat Body  1483.2 Larval Salivary Gland    964.7 Larval Trachea  1172.525 Larval Carcass  1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop  1307.7 Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules  1364.8 Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca  1147.6 Adult InseminatedFemale Spermatheca  1190.5 Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    778.075 Larval Midgut    989.4 Larval Hindgut    1011.6 Larval Malpighian Tubules    1712.4 Larval Fat Body    1483.2 Larval Salivary Gland    964.7 Larval Trachea    1172.525 Larval Carcass    1015.025 Adult Head    669.2 Adult Eye    996.9 Adult Brain    563 Adult Thoracic-Abdominal Ganglion    722.9 Adult Crop    1307.7 Adult Midgut    835.2 Adult Hindgut    912.3 Adult Malpighian Tubules    1364.8 Adult Fat Body    662.4 Adult Salivary Gland    716.1 Adult Heart    813.35 Adult VirginFemale Spermatheca    1147.6 Adult InseminatedFemale Spermatheca    1190.5 Adult Ovary    531 Adult Testis    268.4 Adult Male Accessory Gland    967.9 Adult Carcass    635.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    669.2   NA  Eye    996.9   NA  Brain    563   778.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    722.9   NA  Crop    1307.7   989.4  Midgut    835.2   1011.6  Hindgut    912.3   1712.4  Malpighian Tubules    1364.8   1483.2  Fat Body    662.4   964.7  Salivary Gland    716.1   NA  Heart    813.35   1172.525  Trachea    NA   NA  VirginFemale Spermatheca    1147.6   NA  InseminatedFemale Spermatheca    1190.5   NA  Ovary    531   NA  Testis    268.4   NA  Male Accessory Gland    967.9   1015.025  Carcass    635.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8055-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage shrb4 lethal | recessive shrbk11201 viable shrbEY05194 Sterility Allele fertile shrbEY05194 Other Phenotypes Allele increased cell death, with Scer\GAL4GMR.PF shrbScer\UAS.T:Avic\GFP neuroanatomy defective, with Scer\GAL4221 shrbdsRNA.Scer\UAS shrbScer\UAS.T:Avic\GFP neuroanatomy defective | embryonic stage shrb4 Phenotype manifest in Allele dendrite | dorsal | embryonic stage shrb4 dendritic arborizing neuron | embryonic stage shrb4 dendritic arborizing neuron | embryonic stage (with Df(2R)Np5) shrb4 dendritic arborizing neuron | embryonic stage (with In(2LR)w45-32n) shrb4 dorsal cluster neuron shrb4 dorsal cluster neuron (with Df(2R)Np5) shrb4 dorsal cluster neuron (with In(2LR)w45-32n) shrb4 dorsal multidendritic neuron | embryonic stage 16 shrb4 dorsal multidendritic neuron | embryonic stage 16 (with Df(2R)Np5) shrb4 dorsal multidendritic neuron | embryonic stage 16 (with In(2LR)w45-32n) shrb4 dorsal multidendritic neuron | embryonic stage 17 shrb4 dorsal multidendritic neuron | embryonic stage 17 (with Df(2R)Np5) shrb4 dorsal multidendritic neuron | embryonic stage 17 (with In(2LR)w45-32n) shrb4 dorsal multidendritic neuron ddaA | somatic clone shrb4 dorsal multidendritic neuron ddaB | somatic clone shrb4 dorsal multidendritic neuron ddaC | somatic clone shrb4 dorsal multidendritic neuron ddaD | somatic clone shrb4 dorsal multidendritic neuron ddaE, with Scer\GAL4221 shrbScer\UAS.T:Avic\GFP dorsal multidendritic neuron ddaE & dendritic tree | ectopic, with Scer\GAL4221 shrbdsRNA.Scer\UAS dorsal multidendritic neuron ddaE | somatic clone shrb4 dorsal multidendritic neuron ddaF & dendritic tree | ectopic, with Scer\GAL4221 shrbdsRNA.Scer\UAS dorsal multidendritic neuron ddaF | somatic clone shrb4 eye, with Scer\GAL4GMR.PF shrbScer\UAS.T:Avic\GFP
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of shrb Class Mutagen Stocks Known lesion shrbk11201 P-element activity 2 Yes shrbd02738 P-element activity 1 -- shrbEY05194 P-element activity 1 Yes shrbKG01481 P-element activity 1 Yes shrb4 ethyl methanesulfonate 0 Yes shrbG5 ethyl methanesulfonate 0 Yes shrbO3 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of shrb Class Mutagen Stocks Known lesion shrbKK108557 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes shrbScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes shrbdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes shrbGD10619 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes shrbScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Np5 (Sweeney et al., 2006) In(2LR)w45-32n (Sweeney et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10619} NA P{KK108557} NA P{UAS-shrb.dsRNA} NA P{UAS-shrb.S} NA P{UAS-shrb-GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Prp38EY00788 NA P{EPgy2}shrbEY05194 NA P{XP}shrbd02738 NA insertion of enhancer trap P{lacW}l(2)SH0637SH0637 No P{lacW}shrbk11201 No miscellaneous insertions P{SUPor-P}shrbKG01481 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Gao et al., 1999) negative regulation of growth of symbiont in host inferred from mutant phenotype (Philips et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein transport inferred from electronic annotation with InterPro:IPR005024 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions shrb allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61771 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086656 DroID - A comprehensive database of gene and protein interactions. • FBgn0086656 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35933
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA20793
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001698-PA Aedes aegypti (mosquito) AGAP005316-PA Anopheles gambiae (mosquito) XP_395324.2 Apis mellifera (honey bee) XP_001951538.1 Acyrthosiphon pisum (pea aphid) 26522 Batrachochytrium dendrobatidis (chytrid fungus) 221857 Branchiostoma floridae (lancelet) 252836 Branchiostoma floridae (lancelet) BGIBMGA013801-PA Bombyx mori (silk worm) ENSBTAP00000008352 Bos taurus (bovine) CAL0005125 Candida albicans (a form of yeast) CN18498 Caenorhabditis brenneri (small nematode) CBP06720 Caenorhabditis briggsae (nematode) CE02568 Caenorhabditis elegans (worm) ENSCAFP00000011106 Canis familiaris (dog) CAGL0D01936g Candida glabrata (haploid yeast) ENSCINP00000029640 Ciona intestinalis (sea squirt) JA00979 Caenorhabditis japonica (nematode) cn03639 Cryptococcus neoformans (yeast-like fungus) CPIJ015156 Culex pipens (mosquito) ENSCPOP00000003451 Cavia porcellus (guinea pig) 80582 Chlamidomonas reinhardtii (green alga) RP22678 Caenorhabditis remanei (nematode) ENSCSAVP00000004735 Ciona savignyi (sedentary tunicate) 168545 Capitella spl (polychaete worm) DDB0231531 Dictyostelium discoideum (amoeba) DEHA2D08844g Debaryomyces Hansenii (yeast) 62579 Daphnia pulex (daphnia) ENSDARP00000023938 Danio rerio (zebra fish) ENSECAP00000014656 Equus caballus (horse) ENSGACP00000008108 Gymnopilus aculeatus (mushroom) ENSGALP00000003263 Gallus gallus (chicken) 155763 Hypsipyla robusta (cedar shoot borer) ENSP00000217402 Homo sapiens (human) ISCW008685-PA Ixodes scapularis (deer tick) KLLA0F17820g Kluyveromyces lactis (yeast) 203722 Lottia gigantea (owl limpet) LmjF36.3850 Leishmania major (virus) ENSMODP00000003443 Monodelphis domestica (gray opossum) ENSMMUP00000010591 Macaca mulatta (rhesus monkey) ENSMUSP00000036206 Mus musculus (house mouse) 239385 Nematostella vectensis (starlet anemone) XP_001607501.1 Nasonia vitripennis (wasp) ENSOANP00000023164 Ornithorynchus anatinus (platypus) ENSORLP00000004439 Oryzias latipes (japanese killifish) LOC_Os09g09480.1 Oryza sativa (asian rice) 22101 Ostreococcus tauri (green alga) PHUM004770-PA Pediculus humanus (human body louse) PP23204 Pristionchus pacificus (nematode) 215712 Physcomitrella patens (moss) ENSPPYP00000012207 Pongo pygmaeus (orangutan) 85460 Phytophthora ramorum (sudden oak death pathogen) 138834 Phytophthora sojae (root rot pathogen) 561117 Populus trichocarpa (black cottonwood) ENSPTRP00000022993 Pan troglodytes (chimpanzee) ENSRNOP00000045686 Rattus norvegicus (norway rat) 5002176 Sorghum bicolor (sorghum) YLR025W Saccharomyces cerevisiae (budding yeast) Smp_045710.1 Schistosoma mansoni (trematode parasite) SPAC1142.07c Schizosaccharomyces pombe (fission yeast) XP_798689.1 Strongylocentrotus purpuratus (purple sea urchin) 37535 Trichoplax adhaerens (metazoa) TA09240 Theileria annulata (apicomplexan parasite) XP_969990.1 Tribolium castaneum (red flour beetle) Tc00.1047053511229.100 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511589.250 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009347 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014271 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022889 Xenopus tropicalis (frog) YALI0C16027g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10840 NV10839 LH17022 ISCW008685 FBgn0239740 FBgn0224832 FBgn0205735 FBgn0181875 FBgn0175509 JGI_V11_62579 FBgn0080783 FBgn0155067 FBgn0142558 FBgn0127336 FBgn0102887 FBgn0089984 CPIJ015156 BGIBMGA013801 ACYPI007250 GB15628 AGAP005316 AAEL001698 PB21989 PHUM039570 GLEAN_09279
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	32559 w*; P{UAS-shrb-GFP}2; P{NIG.4699R}3 11016 y1 w67c23; P{lacW}shrbk11201/CyO 19705 y1 w67c23; P{EPgy2}shrbEY05194/CyO 14372 y1; P{SUPor-P}shrbKG01481/SM6a; ry506
Harvard	- P{XP}shrbd02738
Kyoto	102787 y1 w67c23 ; P{lacW}shrbk11201 / CyO
VDRC	v106823 P{KK108557}VIE-260B
Genomic Clones ( 1 )
	BACR10M14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13992
Other clones	DPiM_GH13992
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06167 LD08047 LD31593 LP17081 RE19739 RE20780 RE22443 RE33661 RE37852 RH04819 RH05014 RH07515 RH07516 RH08747 RH13132 RH14231 RH39408 RH39519 RH46486 RH50756 RH51155 RH53151 RH57272 RH59034 RH64845 RH71380 RH74408 RH74758 SD05163 SD13154 SD13155 SD16863 SD25313
Other clones	107227 144689 144777 190578 521756 569452 571157 571158 572838 576485 CK01.79B.E2 Dmel_neb_012374_0829_2712 EC37624 EK061649 EK238607 EK244420 EK250939 EK292622 EN00959 EN14922 EN16221 EN16222 EN17154 EN17735 ESG011a.E7.3_C06 ESG018d.E21_B07 FGH112D07 FGH121D06 RH09087 RH09268 UUGC0931
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35933 247524
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Vps32 CG8055 (Vaccari, 2006.3.1)
Source for database merge of	Source for merge of: CG8055 anon-WO0118547.180 (FlyBase, 1996-) Source for merge of: shrb l(2)k11201 (Sweeney et al., 2006) Source for merge of: shrb Vps32 (Sweeney et al., 2006, Sweeney et al., 2006)
Additional comments	A 31 nucleotide deletion in the coding region of shrb4 confirms that shrb is Vps32. (Sweeney et al., 2006) Source for merge of CG8055 anon-WO0118547.180 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Mutants show aberrant endosome morphology, fail to degrade ubiquitinated cargoes, and a degree of endosomal accumulation of the signaling receptors. (Vaccari and Bilder, 2006) dsRNA made from templates generated with primers directed against Vps32 that is transfected into S2 treated with Listeria monocytogenes reveals Vps32 to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape. (Cheng et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Area matching Drosophila EST AA264253. This EST has sequence similarity to SNF7 genes. (Davies, 2001.3.15) shrb has a function in dendritic development. (Gao et al., 1999) "44F--45E" was stated as revision. (Gao, 1999.11.4, Gao et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136618 RefSeq (Proteins) • NP_610462 DDBJ / EMBL / GenBank • AA264253 AAF58977 AAL39276 AI136001 AI513286 AX094056 AY069131 BH840434 CL610168 CZ472968 Entrez Gene - A searchable database of RefSeq genes. • 35933 UniProtKB/TrEMBL • Q8T0Q4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Snf7 (IPR005024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61771 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086656 DroID - A comprehensive database of gene and protein interactions. • FBgn0086656 DRSC - Results from RNAi screens. • FBgn0086656 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8055-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35933 247524 InParanoid A subset of ortholog calls from InParanoid. • AAEL001698-PA Aedes aegypti (mosquito) AGAP005316-PA Anopheles gambiae (mosquito) XP_395324.2 Apis mellifera (honey bee) XP_001951538.1 Acyrthosiphon pisum (pea aphid) 26522 Batrachochytrium dendrobatidis (chytrid fungus) 221857 Branchiostoma floridae (lancelet) 252836 Branchiostoma floridae (lancelet) BGIBMGA013801-PA Bombyx mori (silk worm) ENSBTAP00000008352 Bos taurus (bovine) CAL0005125 Candida albicans (a form of yeast) CN18498 Caenorhabditis brenneri (small nematode) CBP06720 Caenorhabditis briggsae (nematode) CE02568 Caenorhabditis elegans (worm) ENSCAFP00000011106 Canis familiaris (dog) CAGL0D01936g Candida glabrata (haploid yeast) ENSCINP00000029640 Ciona intestinalis (sea squirt) JA00979 Caenorhabditis japonica (nematode) cn03639 Cryptococcus neoformans (yeast-like fungus) CPIJ015156 Culex pipens (mosquito) ENSCPOP00000003451 Cavia porcellus (guinea pig) 80582 Chlamidomonas reinhardtii (green alga) RP22678 Caenorhabditis remanei (nematode) ENSCSAVP00000004735 Ciona savignyi (sedentary tunicate) 168545 Capitella spl (polychaete worm) DDB0231531 Dictyostelium discoideum (amoeba) DEHA2D08844g Debaryomyces Hansenii (yeast) 62579 Daphnia pulex (daphnia) ENSDARP00000023938 Danio rerio (zebra fish) ENSECAP00000014656 Equus caballus (horse) ENSGACP00000008108 Gymnopilus aculeatus (mushroom) ENSGALP00000003263 Gallus gallus (chicken) 155763 Hypsipyla robusta (cedar shoot borer) ENSP00000217402 Homo sapiens (human) ISCW008685-PA Ixodes scapularis (deer tick) KLLA0F17820g Kluyveromyces lactis (yeast) 203722 Lottia gigantea (owl limpet) LmjF36.3850 Leishmania major (virus) ENSMODP00000003443 Monodelphis domestica (gray opossum) ENSMMUP00000010591 Macaca mulatta (rhesus monkey) ENSMUSP00000036206 Mus musculus (house mouse) 239385 Nematostella vectensis (starlet anemone) XP_001607501.1 Nasonia vitripennis (wasp) ENSOANP00000023164 Ornithorynchus anatinus (platypus) ENSORLP00000004439 Oryzias latipes (japanese killifish) LOC_Os09g09480.1 Oryza sativa (asian rice) 22101 Ostreococcus tauri (green alga) PHUM004770-PA Pediculus humanus (human body louse) PP23204 Pristionchus pacificus (nematode) 215712 Physcomitrella patens (moss) ENSPPYP00000012207 Pongo pygmaeus (orangutan) 85460 Phytophthora ramorum (sudden oak death pathogen) 138834 Phytophthora sojae (root rot pathogen) 561117 Populus trichocarpa (black cottonwood) ENSPTRP00000022993 Pan troglodytes (chimpanzee) ENSRNOP00000045686 Rattus norvegicus (norway rat) 5002176 Sorghum bicolor (sorghum) YLR025W Saccharomyces cerevisiae (budding yeast) Smp_045710.1 Schistosoma mansoni (trematode parasite) SPAC1142.07c Schizosaccharomyces pombe (fission yeast) XP_798689.1 Strongylocentrotus purpuratus (purple sea urchin) 37535 Trichoplax adhaerens (metazoa) TA09240 Theileria annulata (apicomplexan parasite) XP_969990.1 Tribolium castaneum (red flour beetle) Tc00.1047053511229.100 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511589.250 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009347 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014271 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022889 Xenopus tropicalis (frog) YALI0C16027g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35933 modMine - Data generated by the modENCODE project. • FBgn0086656 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10840 NV10839 LH17022 ISCW008685 FBgn0239740 FBgn0224832 FBgn0205735 FBgn0181875 FBgn0175509 JGI_V11_62579 FBgn0080783 FBgn0155067 FBgn0142558 FBgn0127336 FBgn0102887 FBgn0089984 CPIJ015156 BGIBMGA013801 ACYPI007250 GB15628 AGAP005316 AAEL001698 PB21989 PHUM039570 GLEAN_09279
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-WO0118547.180   CG8055 (Sweeney et al., 2006, Cheng et al., 2005, Sweeney et al., 2006, Stuart et al., 2007, Irion and St Johnston, 2007, Philips et al., 2008, Vaccari et al., 2009, Keleman et al., 2009.8.5, Gandhi et al., 2007, Cammarato et al., 2011) ESCRT-III (Juhász et al., 2008, Rusten et al., 2007) shrb   Shrb (Lone et al., 2010) shrub (Sweeney et al., 2006) Snf7 (Vaccari et al., 2009) Snf7/Vps32 (Vaccari and Bilder, 2006) Vps32 (Sweeney et al., 2006, Sweeney et al., 2006, Juhász et al., 2008, Chittaranjan et al., 2009, Vaccari et al., 2009) vps32 (Irion and St Johnston, 2007, Rusten et al., 2007, Vaccari et al., 2009, Saj et al., 2010, Uytterhoeven et al., 2011) vps32/snf7 (Vaccari, 2006.3.1, Irion and St Johnston, 2007)
Name Synonym	shrub (Kruger, 2006, Gao et al., 1999, Sweeney et al., 2006, Vaccari et al., 2009, Ahmad et al., 2009, Cammarato et al., 2011) Vps32 (Vaccari, 2006.3.1)
Secondary FlyBase IDs
	FBgn0028565 FBgn0033385 FBgn0062188
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 9 ) Review  ( 1 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 )
Recent research papers ( 4 )
	Uytterhoeven et al., 2011, Cell 145(1): 117--132 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. [FBrf0213384] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Lone et al., 2010, J. Cell Sci. 123(14): 2369--2374 The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila. [FBrf0211180] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...