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Gene Dmel\ik2

General Information
Symbol	Dmel\ik2	Species	D. melanogaster
Name	IκB kinase-like 2	Annotation symbol	CG2615
Feature type	protein_coding_gene	FlyBase ID	FBgn0086657
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	DmIKKε, l(2)38Ea, 38D.31, IKKε, DIK2
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	38D4-38E2	Sequence location	2L:20,676,234..20,679,308 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene IκB kinase-like 2 is referred to in FlyBase by the symbol Dmel\ik2 (CG2615, FBgn0086657). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; microtubule bundle formation; neuron remodeling; chaeta morphogenesis; regulation of cytoskeleton organization; sensory organ precursor cell division; maintenance of epithelial integrity, open tracheal system; cell morphogenesis; actin filament organization; cell death. 28 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; external compound sense organ; cell part; eo support cell; organelle; humeral trabecule; late extended germ band embryo; integumentary plate. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640036_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of ik2. Gene sequence location is 2L:20676234..20679308.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN50555 BKN50209 BKN22489 HFA03550 References Dubin-Bar et al., 2011, Development 138(21): 4661--4671
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 38D4-38E2   Limits computationally determined from genome sequence between P{lacW}k02501&P{lacW}k14810 and P{PZ}Hr3802306&P{PZ}dia1; Left limit from inclusion within Df(2L)DS9 (FBrf0102956) Right limit from non-inclusion within Df(2L)DS6 (FBrf0102956)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 38E1-38E5     (Inohara, 1999.10.22)
Experimentally Determined Recombination Data
Location	2- (Kozlova et al., 1998)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ik2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ik2-RA FBtr0081389  NM_136204   2744   711 ik2-RB FBtr0081390  NM_165337   2771   720
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ik2-PA   FBpp0080919   81.1   711   6.80     NP_610048   AAF53911 ik2-PB   FBpp0080920   82.0   720   6.88     NP_724278   AAN11082
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Protein kinase, catalytic domain (IPR000719) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53911   AE014134 AAN11082   AC002445   AC004759   AF197914 AAF04853   AI109013   AI543320   AW944617   BI240606   BI354284   BP542345   BP542349   BT003170 AAO24925   BT046140   CA804554   CO311321   CO315784   CO322128   CZ479672   CZ479673   EC052500   EC053530   EC053983   EC056333   EC085930   EC087491   EC215227   EC225870   GH941771   GH941935   GH942941   GH964596   GH978872   GH980638   GH981476   L80120
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3Y8 Q8INU8 Q86PE7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086657    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086657 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086657 expression level Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2229) embryo 02-04hr  (1298) embryo 04-06hr  (2280) embryo 06-08hr  (1871) embryo 08-10hr  (1595) embryo 10-12hr  (1181) embryo 12-14hr  (1038) embryo 14-16hr  (623) embryo 16-18hr  (478) embryo 18-20hr  (365) embryo 20-22hr  (371) embryo 22-24hr  (484) larva L1  (442) larva L2  (548) larva L3 12hr old  (518) larva L3 puffstage 1-2  (667) larva L3 puffstage 3-6  (864) larva L3 puffstage 7-9  (1358) white prepupae new  (1431) white prepupae 12hr  (1475) white prepupae 24hr  (1282) pupae 2d postWPP  (1102) pupae 3d postWPP  (490) pupae 4d postWPP  (348) adult male 01day  (518) adult male 05day  (522) adult male 30day  (482) adult female 01day  (761) adult female 05day  (1582) adult female 30day  (1512) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2229) embryo 02-04hr    1298 embryo 04-06hr  (2280) embryo 06-08hr  (1871) embryo 08-10hr  (1595) embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new  1431 white prepupae 12hr  1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day  (1582) adult female 30day  (1512) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086657 expression level Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2229) embryo 02-04hr  (1298) embryo 04-06hr  (2280) embryo 06-08hr  (1871) embryo 08-10hr  (1595) embryo 10-12hr  (1181) embryo 12-14hr  (1038) embryo 14-16hr  (623) embryo 16-18hr  (478) embryo 18-20hr  (365) embryo 20-22hr  (371) embryo 22-24hr  (484) larva L1  (442) larva L2  (548) larva L3 12hr old  (518) larva L3 puffstage 1-2  (667) larva L3 puffstage 3-6  (864) larva L3 puffstage 7-9  (1358) white prepupae new  (1431) white prepupae 12hr  (1475) white prepupae 24hr  (1282) pupae 2d postWPP  (1102) pupae 3d postWPP  (490) pupae 4d postWPP  (348) adult male 01day  (518) adult male 05day  (522) adult male 30day  (482) adult female 01day  (761) adult female 05day  (1582) adult female 30day  (1512) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2229 embryo 02-04hr    1298 embryo 04-06hr  2280 embryo 06-08hr  1871 embryo 08-10hr  1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new  1431 white prepupae 12hr  1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day  1582 adult female 30day  1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2229 embryo 02-04hr    1298 embryo 04-06hr    2280 embryo 06-08hr    1871 embryo 08-10hr    1595 embryo 10-12hr    1181 embryo 12-14hr    1038 embryo 14-16hr    623 embryo 16-18hr    478 embryo 18-20hr    365 embryo 20-22hr    371 embryo 22-24hr    484 larva L1    442 larva L2    548 larva L3 12hr old    518 larva L3 puffstage 1-2    667 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    1358 white prepupae new    1431 white prepupae 12hr    1475 white prepupae 24hr    1282 pupae 2d postWPP    1102 pupae 3d postWPP    490 pupae 4d postWPP    348 adult male 01day    518 adult male 05day    522 adult male 30day    482 adult female 01day    761 adult female 05day    1582 adult female 30day    1512 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086657    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086657 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086657 expression level Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086657 expression level Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.175 Larval Midgut no informative data Larval Hindgut    18.2 Larval Malpighian Tubules    27.4 Larval Fat Body    50.5 Larval Salivary Gland    27.9 Larval Trachea    25.15 Larval Carcass    27.625 Adult Head no informative data Adult Eye    28.025 Adult Brain    28.8 Adult Thoracic-Abdominal Ganglion    41.6 Adult Crop    39.6 Adult Midgut no informative data Adult Hindgut    25.6 Adult Malpighian Tubules    17.3 Adult Fat Body    49.4 Adult Salivary Gland    27.7 Adult Heart    23.525 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    30.7 Adult Ovary    73.1 Adult Testis    10.1 Adult Male Accessory Gland    27.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    28.025   NA  Brain    28.8   45.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    41.6   NA  Crop    39.6   no informative data  Midgut    no informative data   18.2  Hindgut    25.6   27.4  Malpighian Tubules    17.3   50.5  Fat Body    49.4   27.9  Salivary Gland    27.7   NA  Heart    23.525   25.15  Trachea    NA   NA  VirginFemale Spermatheca    21.1   NA  InseminatedFemale Spermatheca    30.7   NA  Ovary    73.1   NA  Testis    10.1   NA  Male Accessory Gland    27.7   27.625  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2615-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dorsal-ventral polarity | first instar larval stage | maternal effect | recessive ik21 ik2alice lethal | first instar larval stage | recessive ik22 ik23 ik24 ik25 lethal | recessive ik21 ik22 ik23 ik24 ik25 viable, with Scer\GAL4pnr-MD237 ik2GD5424 Other Phenotypes Allele cell shape defective ik2Ubi-p63E.PO cell shape defective, with Scer\GAL4Act5C.PI ik2DN.Scer\UAS ik2dsRNA.Scer\UAS increased cell death ik2hs.PK ik2Ubi-p63E.PO increased cell death, with Scer\GAL4Act5C.PHb ik2Scer\UAS.T:Hsap\MYC increased cell death, with Scer\GAL4GMR.PF ik2Scer\UAS.cKa increased cell death | larval stage | heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B ik2Scer\UAS.cKa neuroanatomy defective, with Scer\GAL4ppk.1.9 ik2KK102408 neuroanatomy defective | larval stage | heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B ik2Scer\UAS.cKa neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG ik2DN.Scer\UAS ik2dsRNA.Scer\UAS ik2G250D.Scer\UAS.T:Hsap\MYC ik2GD5424 neuroanatomy defective | pupal stage | somatic clone ik21 ik2alice visible, with Scer\GAL4pnr-MD237 ik2GD5424 Phenotype manifest in Allele arista lateral, with Scer\GAL4ap-md544 ik2DN.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6 ik2Scer\UAS.cOa cuticle | germline clone ik21 ik2alice dendrite, with Scer\GAL4ppk.1.9 ik2KK102408 dendrite & dorsal multidendritic neuron ddaC | larval stage | conditional - heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B ik2Scer\UAS.cKa dendrite & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG ik2DN.Scer\UAS ik2dsRNA.Scer\UAS ik2G250D.Scer\UAS.T:Hsap\MYC ik2GD5424 dendrite & dorsal multidendritic neuron ddaC | pupal stage | somatic clone ik21 ik2alice dorsal appendage | germline clone ik21 ik2alice dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9 ik2KK102408 egg chamber & microtubule | germ-line clone ik21 ik2alice embryonic/first instar larval cuticle | germline clone ik21 ik2alice embryonic abdomen | ectopic | germline clone ik21 ik2alice embryonic head | germline clone ik21 ik2alice embryonic tracheole, with Scer\GAL4btl.PS ik2GS11377 eye, with Scer\GAL4GMR.PF ik2Scer\UAS.cKa humeral bristle ik21 ik22 ik23 ik24 ik25 ik2alice interommatidial bristle ik21 ik22 ik23 ik24 ik25 ik2alice macrochaeta, with Scer\GAL4ap-md544 ik2DN.Scer\UAS ik2dsRNA.Scer\UAS macrochaeta, with Scer\GAL4neur-GAL4-A101 ik2DN.Scer\UAS ik2GD5424 macrochaeta, with Scer\GAL4sca-P309 ik2dsRNA.Scer\UAS macrochaeta | supernumerary, with Scer\GAL4sca-P309 ik2Scer\UAS.cKa microtubule, with Scer\GAL4neur-GAL4-A101 ik2DN.Scer\UAS ik2GD5424 microtubule & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG ik2dsRNA.Scer\UAS ik2G250D.Scer\UAS.T:Hsap\MYC ik2GD5424 S2 cell-line & filamentous actin ik2MtnA.PO S2 cell-line & filamentous actin, with Scer\GAL4Act5C.PI ik2DN.Scer\UAS S2 cell-line & plasma membrane ik2MtnA.PO scutellar bristle, with Scer\GAL4neur-GAL4-A101 ik2DN.Scer\UAS ik2GD5424 sensory mother cell | supernumerary, with Scer\GAL4sca-P309 ik2Scer\UAS.cKa stage S7 oocyte & actin cytoskeleton | germ-line clone ik21 ik2alice terminal tracheal cell ik25 terminal tracheal cell, with Scer\GAL4btl.PS ik2dsRNA.Scer\UAS terminal tracheal cell & filamentous actin ik25 terminal tracheal cell & filopodium ik25 trichogen cell, with Scer\GAL4pnr-MD237 ik2GD5424
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of ik2 Class Mutagen Stocks Known lesion ik21 ethyl methanesulfonate 1 Yes ik25 loss of function allele ethyl methanesulfonate 1 Yes ik2alice ethyl methanesulfonate 1 Yes ik2e01853 piggyBac transposase 1 -- ik2GS11377 1 -- ik2MB11506 1 -- ik22 ethyl methanesulfonate 0 Yes ik23 ethyl methanesulfonate 0 Yes ik24 ethyl methanesulfonate 0 Yes ik2Ubi-p63E.PO 0 Yes
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ik2 Class Mutagen Stocks Known lesion ik2GD5424 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes ik2GL00160 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ik2HMS01188 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ik2KK102408 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ik2D160N.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ik2DN.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ik2dsRNA.cSa in vitro construct - RNAi 0 Yes ik2dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ik2G19R.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ik2G250D.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ik2hs.PK in vitro construct - regulatory fusion 0 Yes ik2MtnA.PO in vitro construct - regulatory fusion 0 Yes ik2Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes ik2Scer\UAS.cOa in vitro construct - regulatory fusion 0 Yes ik2Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ik2Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ik2Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ik2ΔUbl.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)DS5 (Butler et al., 2001) Df(2L)DS9 (Kozlova et al., 1998, Butler et al., 2001) Df(2L)Exel7078 (Ryder, 2004.4.26) Df(2L)Fs(2)Ket-RX32 (Kozlova et al., 1998, Butler et al., 2001, Shapiro and Anderson, 2006) Df(2L)pr11 (Butler et al., 2001) Df(2L)pr9204 (Butler et al., 2001) Df(2L)pr11163 (Butler et al., 2001) Df(2L)TW2 (Butler et al., 2001)
Not disrupted in	Df(2L)DS6 (Kozlova et al., 1998, Butler et al., 2001) Df(2L)pr2b (Butler et al., 2001) Df(2L)pr37 (Butler et al., 2001) Df(2L)pr8311 (Butler et al., 2001) Df(2L)pr-A16 (Butler et al., 2001) Df(2L)Sd14 (Butler et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5424} NA P{KK102408} NA P{TRiP.GL00160} NA P{TRiP.HMS01188} NA P{UAS-ik2.DN} NA P{UAS-ik2.dsRNA} NA P{UAS-ik2.MYC} NA P{UAS-ik2.O} NA P{UASp-EGFP-ik2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}ik2e01853 NA insertion of mobile activating element P{GSV6}ik2GS11377 NA insertion of enhancer trap binary system Mi{ET1}ik2MB11506 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with th (Kuranaga et al., 2006)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Oshima et al., 2006) cell death inferred from mutant phenotype (Kuranaga et al., 2006) cell morphogenesis inferred from mutant phenotype (Oshima et al., 2006) chaeta morphogenesis inferred from mutant phenotype (Bitan et al., 2010) maintenance of epithelial integrity, open tracheal system inferred from mutant phenotype (Oshima et al., 2006) microtubule bundle formation inferred from mutant phenotype (Bitan et al., 2010) neuron remodeling inferred from mutant phenotype (Lee et al., 2009) positive regulation of cysteine-type endopeptidase activity involved in apoptotic process inferred from mutant phenotype (Kuranaga et al., 2006) regulation of cytoskeleton organization inferred from physical interaction with spn-F (Dubin-Bar et al., 2008) sensory organ precursor cell division inferred from genetic interaction with th (Koto et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) IkappaB kinase activity non-traceable author statement (Inohara, 1999.10.22) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity with UniProtKB:Q14164 (FlyBase, 1992-)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) non-traceable author statement (Inohara, 1999.10.22, Morrison et al., 2000) signal transduction non-traceable author statement (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
IkappaB kinase complex non-traceable author statement (Inohara, 1999.10.22)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ik2 allele Gene References unspecified rpr (Kuranaga et al., 2006) th (Oshima et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61292 DroID - A comprehensive database of gene and protein interactions. • FBgn0086657 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35329
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA15402
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005359-PA Aedes aegypti (mosquito) AGAP009565-PA Anopheles gambiae (mosquito) XP_396937.3 Apis mellifera (honey bee) XP_001946184.1 Acyrthosiphon pisum (pea aphid) 199352 Branchiostoma floridae (lancelet) BGIBMGA000198-PA Bombyx mori (silk worm) ENSBTAP00000023134 Bos taurus (bovine) CE28702 Caenorhabditis elegans (worm) ENSCAFP00000000505 Canis familiaris (dog) ENSCINP00000011687 Ciona intestinalis (sea squirt) CPIJ006852 Culex pipens (mosquito) ENSCPOP00000009741 Cavia porcellus (guinea pig) ENSCSAVP00000002756 Ciona savignyi (sedentary tunicate) 124995 Capitella spl (polychaete worm) 300170 Daphnia pulex (daphnia) ENSDARP00000014302 Danio rerio (zebra fish) ENSDARP00000074566 Danio rerio (zebra fish) ENSECAP00000018587 Equus caballus (horse) ENSGACP00000000783 Gymnopilus aculeatus (mushroom) ENSGALP00000015982 Gallus gallus (chicken) 191604 Hypsipyla robusta (cedar shoot borer) ENSP00000329967 Homo sapiens (human) 105441 Lottia gigantea (owl limpet) ENSMODP00000002458 Monodelphis domestica (gray opossum) ENSMMUP00000010063 Macaca mulatta (rhesus monkey) ENSMUSP00000020316 Mus musculus (house mouse) XP_001605938.1 Nasonia vitripennis (wasp) ENSOANP00000015719 Ornithorynchus anatinus (platypus) ENSORLP00000019746 Oryzias latipes (japanese killifish) PHUM005407-PA Pediculus humanus (human body louse) ENSPPYP00000005386 Pongo pygmaeus (orangutan) ENSPTRP00000008798 Pan troglodytes (chimpanzee) ENSRNOP00000009260 Rattus norvegicus (norway rat) XP_001191421.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969718.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005945 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000005087 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015947 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18477 NV14464 LH23091 ISCW020049 FBgn0230090 FBgn0217057 FBgn0210090 FBgn0195622 FBgn0178230 JGI_V11_300170 FBgn0075421 FBgn0156115 FBgn0140989 FBgn0118358 FBgn0113426 FBgn0092374 CPIJ006852 BGIBMGA000198 ACYPI008988 GB14720 AGAP009565 AAEL005359 PHUM387680 GLEAN_09798
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	5322 ik21 dpov1 bw1/CyO 29218 w1118; Mi{ET1}ik2MB11506/SM6a 35266 y1 sc* v1; P{TRiP.GL00160}attP2 34709 y1 sc* v1; P{TRiP.HMS01188}attP2 5324 y1 w*; ik25 dpov1 bw1/CyO, y+ 31035 w*; al1 dpov1 b1 pr1 ik2alice P{neoFRT}40A/CyO, P{hs-hid}4
Harvard	- PBac{RB}ik2e01853
Kyoto	203285 y1 w67c23; P{GSV6}ik2GS11377/SM1
VDRC	v103748 P{KK102408}VIE-260B v12485 w1118; P{GD5424}v12485 v49366 w1118; P{GD5424}v49366 v49365 w1118; P{GD5424}v49365/CyO
Genomic Clones ( 1 )
	BACR31P14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 26 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10041
Other clones	FI05319
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07508 GM18862 RE37485
Other clones	61650 97959 118155 159643 EC052500 EC053530 EC053983 EC056333 EK187263 EK224137 EK262436 ESG0114a.B21_G06 FGC012B04 FGC012B09 RP004231541 RP004239161 RP004253987 RP004254338 RP004260894 RP004263010 RP004501742
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35329 47704
Antibody Information
	polyclonal (Otani et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ik2 CG2615 (Adams, 1999.11)
Source for database merge of	Source for merge of: ik2 l(2)38Ea (Shapiro and Anderson, 2006)
Additional comments
Other Comments
	Mutations in ik2 affect polarized bristle microtubule formation. (Bitan et al., 2010) ik2 is required for dendritic severing during dendrite pruning of ddaC neurons in the pupa. (Lee et al., 2009) ik2 acts upstream of the Tl-dl pathway during oogenesis. (Shapiro and Anderson, 2006) Both the actin cytoskeleton and the anchoring of microtubule minus-ends are disrupted in ik2 mutants. (Shapiro and Anderson, 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities and spindle abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136204 NM_165337 RefSeq (Proteins) • NP_610048 NP_724278 DDBJ / EMBL / GenBank • AAF04853 AAF53911 AAN11082 AAO24925 AC002445 AC004759 AF197914 AI543320 AW944617 BT003170 CZ479672 CZ479673 L80120 Entrez Gene - A searchable database of RefSeq genes. • 35329 UniProtKB/TrEMBL • Q8INU8 Q9V3Y8 Q86PE7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Protein kinase, catalytic domain (IPR000719) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61292 DroID - A comprehensive database of gene and protein interactions. • FBgn0086657 DRSC - Results from RNAi screens. • FBgn0086657 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2615-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35329 47704 InParanoid A subset of ortholog calls from InParanoid. • AAEL005359-PA Aedes aegypti (mosquito) AGAP009565-PA Anopheles gambiae (mosquito) XP_396937.3 Apis mellifera (honey bee) XP_001946184.1 Acyrthosiphon pisum (pea aphid) 199352 Branchiostoma floridae (lancelet) BGIBMGA000198-PA Bombyx mori (silk worm) ENSBTAP00000023134 Bos taurus (bovine) CE28702 Caenorhabditis elegans (worm) ENSCAFP00000000505 Canis familiaris (dog) ENSCINP00000011687 Ciona intestinalis (sea squirt) CPIJ006852 Culex pipens (mosquito) ENSCPOP00000009741 Cavia porcellus (guinea pig) ENSCSAVP00000002756 Ciona savignyi (sedentary tunicate) 124995 Capitella spl (polychaete worm) 300170 Daphnia pulex (daphnia) ENSDARP00000014302 Danio rerio (zebra fish) ENSDARP00000074566 Danio rerio (zebra fish) ENSECAP00000018587 Equus caballus (horse) ENSGACP00000000783 Gymnopilus aculeatus (mushroom) ENSGALP00000015982 Gallus gallus (chicken) 191604 Hypsipyla robusta (cedar shoot borer) ENSP00000329967 Homo sapiens (human) 105441 Lottia gigantea (owl limpet) ENSMODP00000002458 Monodelphis domestica (gray opossum) ENSMMUP00000010063 Macaca mulatta (rhesus monkey) ENSMUSP00000020316 Mus musculus (house mouse) XP_001605938.1 Nasonia vitripennis (wasp) ENSOANP00000015719 Ornithorynchus anatinus (platypus) ENSORLP00000019746 Oryzias latipes (japanese killifish) PHUM005407-PA Pediculus humanus (human body louse) ENSPPYP00000005386 Pongo pygmaeus (orangutan) ENSPTRP00000008798 Pan troglodytes (chimpanzee) ENSRNOP00000009260 Rattus norvegicus (norway rat) XP_001191421.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969718.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005945 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000005087 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015947 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/ikkepsilon1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35329 modMine - Data generated by the modENCODE project. • FBgn0086657 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18477 NV14464 LH23091 ISCW020049 FBgn0230090 FBgn0217057 FBgn0210090 FBgn0195622 FBgn0178230 JGI_V11_300170 FBgn0075421 FBgn0156115 FBgn0140989 FBgn0118358 FBgn0113426 FBgn0092374 CPIJ006852 BGIBMGA000198 ACYPI008988 GB14720 AGAP009565 AAEL005359 PHUM387680 GLEAN_09798
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	38D.31 (McGill Drosophila Genome Project, 2001.9.25, Butler, 2001, Butler et al., 2001) APTX7 (Kuranaga et al., 2006) CG2615 (Kuranaga et al., 2006, Oshima et al., 2006, Morrison et al., 2000, Sinka et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Ni et al., 2011.7.19) DIK2 (Morrison et al., 2000) dik2 (Inohara, 1999.10.22) Dik2   dIKK (Mushegian and Medzhitov, 2001) Dmik2 (Lemaitre, 2000.12.20) DmIKKε (Kuranaga et al., 2006, Bergmann, 2006, Liao et al., 2002, Wasserman, 2000) DmIKKε/dIK2 (Silverman and Maniatis, 2001) DmIKKε (Koto et al., 2009) ik2 (Shapiro and Anderson, 2006, Oshima et al., 2006, Lazzaro et al., 2006, Dubin-Bar and Abdu, 2007, Matthews, 2007.10.18, Somma et al., 2008, Dubin-Bar et al., 2008, Lee et al., 2009, Bitan et al., 2010, Tao and Rolls, 2011, Dubin-Bar et al., 2011) Ik2 (Bergmann, 2006, Wasserman, 2000, Caussinus et al., 2008) IK2 (Sun et al., 2002, Sun et al., 2002, Lazzaro et al., 2004) Ik2/DmIKK (Kuranaga et al., 2006) IKK (Silverman et al., 2008) IKKε (Oshima, 2006, Oshima et al., 2006, ) l(2)38Ea (Oshima, 2006, Kuranaga et al., 2006, Kozlova et al., 2009)
Name Synonym	apoptoxin 7 (Kuranaga et al., 2006) ik2   IkappaB kinase-like 2 (Caussinus et al., 2008) IKK-related kinase (Dubin-Bar et al., 2008) IκB kinase-like 2 (Shapiro and Anderson, 2006) lethal (2) 38Ea
Secondary FlyBase IDs
	FBgn0025164 FBgn0028633 FBgn0043071
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 8 ) Review  ( 6 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Dubin-Bar et al., 2011, Development 138(21): 4661--4671 Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. [FBrf0216406] Otani et al., 2011, Dev. Cell 20(2): 219--232 IKKɛ Regulates Cell Elongation through Recycling Endosome Shuttling. [FBrf0212985] Tao and Rolls, 2011, J. Neurosci. 31(14): 5398--5405 Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. [FBrf0213404] Bitan et al., 2010, Mol. Cell. Biol. 30(2): 496--507 Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. [FBrf0209571] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...