benchwarmer, l(2)10403, l(2)k09905, bnch, diphthong
conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior - a putative lysosomal efflux permease with the hallmarks of a sugar transporter - essential for mTOR reactivation and lysosome reformation following prolonged starvation
Low-frequency RNA-Seq exon junction(s) not annotated.
Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.
Gene model reviewed during 5.50
Alternative translation stop created by use of multiphasic reading frames within coding region.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spin using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\spin in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of spin CG8428 was sequence comparison ( date:010104 ).
spin is required both pre- and post-synaptically for normal synaptic growth at the neuromuscular junction.
Mutant females show strong rejection behaviour in response to male courtship. Mutants of both sexes show a decrease in viability and adult lifespan. Loss of spin gene function interferes with programmed cell death of neurons and nurse cells.
Identification: In a genetic screen for components of the muscle to nerve trans-synaptic signaling system.
Loss-of-function mutations lead to an overgrowth of the neuromuscular synapse (50-150% increase in bouton number). Synaptic function is normal despite the large increase in synapse size.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.
The name 'benchwarmer' refers to the overall lower level of locomotor activity displayed by mutant adult escapers and honors athletes who play rarely and therefore sit on the bench.