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Gene Dmel\jeb

General Information
Symbol	Dmel\jeb	Species	D. melanogaster
Name	jelly belly	Annotation symbol	CG30040
Feature type	protein_coding_gene	FlyBase ID	FBgn0086677
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48E1-48E2	Sequence location	2R:7,978,127..8,006,377 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene jelly belly is referred to in FlyBase by the symbol Dmel\jeb (CG30040, FBgn0086677). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: visceral muscle development; axon guidance; compound eye photoreceptor development; salivary gland morphogenesis. 13 alleles are reported. The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; visceral mesoderm; neuromuscular junction; embryonic/larval digestive system; circular visceral muscle primordium; embryonic visceral muscle; endoderm. It has one annotated transcript and one annotated polypeptide. Protein features are: Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1631060_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of jeb. Gene sequence location is 2R:7978127..8006377.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Alleles jeb[Scer\UAS.cRa] References Gouzi et al., 2011, PLoS Genet. 7(9): e1002281 Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Sequence features BKN31857 HFA06305 HFA06307
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48E1-48E2   Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 48E1-48E2     (Oh et al., 2003) 48E9-48E9     (Weiss, 2001.9.27) 48E9-48E9   (determined by in situ hybridisation)   (Weiss et al., 2001) 48E1-48E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 48E1-48E2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\jeb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) jeb-RA FBtr0088021  NM_136882   4482   560
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein jeb-PA   FBpp0087128   61.5   560   6.32     NP_610726   AAF58582
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58582   AB082046   AF425733 AAL30510   AF425734 AAL30511   AI293149   AQ034149   AW940617   AY060310 AAL25349   AY089516   BI584109   BI627153   BI635484   CO271322   CO309951   CZ479995   EC197585   EC213354
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95NU8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 8 -- 10   somatic mesoderm | segmentally repeated & ventral   (Weiss et al., 2001) embryonic stage 11 -- 12   somatic mesoderm   (Weiss et al., 2001) embryonic stage 16   neuron | subset of ventral nerve cord   (Weiss et al., 2001) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17     (Weiss et al., 2001)
Additional Descriptive Data
	jeb transcript is embryonically expressed in the ventral somatic mesoderm, adjacent to dorsal visceral mesoderm precursors. Somatic mesoderm expression is detected beginning at embryonic stage 8, and can no longer be detected at stage 12. At embryonic stage 10 jeb expressing cell clusters are interdigitated with bap-expressing cell clusters. At embryonic stage 11, jeb-expressing cells form continuous stripes that are adjacent and ventral to bap-expressing cells. At embryonic stage 16, jeb is expressed in a subset of neurons in the ventral nerve cord. (Weiss et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   fusion competent cell   • cell surface (Stute et al., 2004) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   visceral mesoderm | dorsal   • cytoplasm | punctate (Weiss et al., 2001) Comment:jeb is taken up by, but not expressed in, this tissue embryonic stage 11   visceral mesoderm | restricted   • cell surface (Stute et al., 2004) muscle founder cell   • cell surface (Stute et al., 2004) embryonic stage 17   longitudinal connective   (Weiss et al., 2001) neuron   • axon (Weiss et al., 2001)
Additional Descriptive Data
	Secreted jeb protein is taken up by Alk-expressing cells in the visceral mesoderm. (Stute et al., 2004) jeb protein is secreted from cells in the somatic mesoderm and taken up by cells in the visceral mesoderm. Later in development, jeb is localized to a subset of axons in the ventral nerve cord, including the longitudinal connectives, and axons projecting to the periperal nervous system. (Weiss et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086677    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086677 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086677 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr  (218) embryo 06-08hr  (647) embryo 08-10hr  (110) embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr  (202) embryo 20-22hr  (260) embryo 22-24hr  (266) larva L1  (330) larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr  (196) white prepupae 24hr  (286) pupae 2d postWPP  (225) pupae 3d postWPP  (135) pupae 4d postWPP    96 adult male 01day  (129) adult male 05day  (138) adult male 30day  (143) adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086677 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr  (218) embryo 06-08hr  (647) embryo 08-10hr  110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr  (202) embryo 20-22hr  (260) embryo 22-24hr  (266) larva L1  (330) larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr  (196) white prepupae 24hr  (286) pupae 2d postWPP  (225) pupae 3d postWPP  135 pupae 4d postWPP    96 adult male 01day  129 adult male 05day  138 adult male 30day  143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    56 embryo 04-06hr    218 embryo 06-08hr    647 embryo 08-10hr    110 embryo 10-12hr    30 embryo 12-14hr    21 embryo 14-16hr    44 embryo 16-18hr    84 embryo 18-20hr    202 embryo 20-22hr    260 embryo 22-24hr    266 larva L1    330 larva L2    94 larva L3 12hr old    42 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    53 larva L3 puffstage 7-9    56 white prepupae new    69 white prepupae 12hr    196 white prepupae 24hr    286 pupae 2d postWPP    225 pupae 3d postWPP    135 pupae 4d postWPP    96 adult male 01day    129 adult male 05day    138 adult male 30day    143 adult female 01day    54 adult female 05day    13 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086677    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086677 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086677 expression level Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086677 expression level Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.25 Larval Midgut    0.9 Larval Hindgut    2.8 Larval Malpighian Tubules    4.4 Larval Fat Body    2.7 Larval Salivary Gland    1.3 Larval Trachea    2.2 Larval Carcass    2.7 Adult Head no informative data Adult Eye    6.4 Adult Brain    94.4 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    5.3 Adult Midgut    1.9 Adult Hindgut    3.5 Adult Malpighian Tubules    3.3 Adult Fat Body    7.5 Adult Salivary Gland no informative data Adult Heart    1.775 Adult VirginFemale Spermatheca    4.1 Adult InseminatedFemale Spermatheca    2.4 Adult Ovary    1.9 Adult Testis    1.2 Adult Male Accessory Gland    5.4 Adult Carcass    9.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    6.4   NA  Brain    94.4   33.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    65.6   NA  Crop    5.3   0.9  Midgut    1.9   2.8  Hindgut    3.5   4.4  Malpighian Tubules    3.3   2.7  Fat Body    7.5   1.3  Salivary Gland    no informative data   NA  Heart    1.775   2.2  Trachea    NA   NA  VirginFemale Spermatheca    4.1   NA  InseminatedFemale Spermatheca    2.4   NA  Ovary    1.9   NA  Testis    1.2   NA  Male Accessory Gland    5.4   2.7  Carcass    9.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30040-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive jebSH0422 lethal | recessive jeb-c1 jebk05644 jebk13306a jebSH0422 viable, with Scer\GAL4elav-C155 jebScer\UAS.cVa viable, with Scer\GAL4pnr-MD237 jebGD5472 Other Phenotypes Allele learning defective | adult stage, with Scer\GAL4Alk.38, Scer\GAL80ts.αTub84B jebScer\UAS.cVa learning defective | adult stage, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B jebScer\UAS.cVa learning defective | adult stage, with Scer\GAL4Ras64B.PW, Scer\GAL80ts.αTub84B jebScer\UAS.cVa locomotor rhythm defective jebk05644 neuroanatomy defective | somatic clone jebSH0422 neurophysiology defective jebk05644 size defective | pupal stage, with Scer\GAL4386Y jebScer\UAS.cVa size defective | pupal stage, with Scer\GAL4Alk.38 jebScer\UAS.cVa size defective | pupal stage, with Scer\GAL4elav-C155 jebScer\UAS.cVa size defective | pupal stage, with Scer\GAL4Ras64B.PW jebScer\UAS.cVa Phenotype manifest in Allele axon & photoreceptor cell R1 | somatic clone jebSH0422 axon & photoreceptor cell R2 | somatic clone jebSH0422 axon & photoreceptor cell R3 | somatic clone jebSH0422 axon & photoreceptor cell R4 | somatic clone jebSH0422 axon & photoreceptor cell R5 | somatic clone jebSH0422 axon & photoreceptor cell R6 | somatic clone jebSH0422 axon & photoreceptor cell R8 | somatic clone jebSH0422 circular visceral muscle primordium jeb-c1 jebk05644 jebweli circular visceral muscle primordium, with Scer\GAL4bap.3 jebScer\UAS.cVa embryonic/larval digestive system jebk05644 embryonic visceral muscle jeb-c1 jebSH0422 endoderm jeb-c1 jebk05644 fusion competent cell & visceral mesoderm, with Scer\GAL4twi.PG jebScer\UAS.cWa fusion competent cell & visceral muscle primordium jebweli muscle founder cell & circular visceral muscle primordium jebweli muscle founder cell & visceral mesoderm, with Scer\GAL4twi.PG jebScer\UAS.cWa muscle founder cell & visceral muscle primordium jeb-c1 jebk05644 muscle founder cell & visceral muscle primordium | ectopic, with Scer\GAL4twi.2PE jebScer\UAS.cWa neuromuscular junction jebk05644 optic cartridge | somatic clone jebSH0422 presumptive embryonic salivary gland jeb-c1 jebk05644 visceral mesoderm jeb-c1 jebk05644 visceral mesoderm, with Scer\GAL4bap.3 jebScer\UAS.cWa
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of jeb Class Mutagen Stocks Known lesion jebk05644 P-element activity 2 Yes jebe02168 piggyBac transposase 1 -- jebk13306a P-element activity 1 -- jebMI03124 1 -- jeb-c1 P-element activity 0 Yes jebSH0422 P-element activity 0 Yes jebunspecified 0 -- jebweli ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of jeb Class Mutagen Stocks Known lesion jebGD5472 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes jebKK111857 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes jebScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes jebScer\UAS.cVa in vitro construct - regulatory fusion 0 Yes jebScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)vg135 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2R)BSC40 (Deal-Herr and Cook, 2003.8.29, Bazigou et al., 2007) Df(2R)BSC199 (Christensen and Cook, 2006.8.30) Df(2R)BSC699 (Christensen et al., 2008.12.28) Df(2R)BSC879 (Cook and Cook, 2010.5.7)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5472} NA P{KK111857} NA P{UAS-jeb.V} NA P{UAS-jeb.W} NA reporter construct P{jeb-lacZ.B} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}jebk05644 No P{lacW}jebk13306a No P{lacW}l(2)SH0422SH0422 No miscellaneous insertions Mi{MIC}jebMI03124 NA PBac{RB}jebe02168 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Bazigou et al., 2007) compound eye photoreceptor development inferred from mutant phenotype (Bazigou et al., 2007) salivary gland morphogenesis inferred from mutant phenotype (Vining et al., 2005) visceral muscle development inferred from mutant phenotype (Weiss et al., 2001, Englund et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mesoderm migration involved in gastrulation non-traceable author statement (Weiss, 2001.9.27) traceable author statement (Taylor, 2002)
Cellular Component
CV term Evidence References
extracellular region traceable author statement (Taylor, 2002)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions jeb allele Gene References jeb-c1 Ras85D (Lee et al., 2003)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0086677 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36295
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmir\jeb (Bartolome and Charlesworth, 2006) Dpse\GA15598
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001897520.1 Brugia malayi (roundworm nematode) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23736 ISCW023412 FBgn0231146 FBgn0223964 FBgn0208779 FBgn0196354 FBgn0186917 FBgn0175271 JGI_V11_263759 FBgn0075615 FBgn0154989 FBgn0141383 FBgn0128503 FBgn0114780 FBgn0089681 CPIJ013661 ACYPI24769 PHUM211900 GLEAN_01096
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	36200 y1 w*; Mi{MIC}jebMI03124/SM6a 10576 w67c23; P{lacW}jebk05644/CyO, P{sevRas1.V12}FK1
Harvard	- PBac{RB}jebe02168
Kyoto	102865 y1 w67c23 ; P{lacW}jebk13306a / CyO 111183 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}jebk05644 /CyO y+
VDRC	v103047 P{KK111857}VIE-260B v30799 w1118; P{GD5472}v30799 v30800 w1118; P{GD5472}v30800
Genomic Clones ( 1 )
	BACR04E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH16255 GM03978
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH68383 SD16850
Other clones	97582 CK01.167C.H5 EK103031 EK220021 RH22891
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36295
Antibody Information
	polyclonal (Weiss et al., 2001) polyclonal antibody (Stute et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: jelly-belly CG13180 CG13182 (FlyBase, 1996-)
Source for database merge of	Source for merge of: jeb l(2)k05644 (Weiss, 2002.1.2) Source for merge of: jeb l(2)SH0422 (Bazigou et al., 2007)
Additional comments	Annotations CG13180, CG13182 merged as CG30040 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of jelly-belly CG13180 CG13182 was sequence comparison (date:011117). (FlyBase, 1996-)
Other Comments
	jeb is required in R1-R6 cells to target their axons to the appropriate sets of target neurons in the lamina. (Bazigou et al., 2007) ChEST reveals this is a target of Mef2. (Junion et al., 2005) 1 allele of l(2)SH0422 recovered in a P-insertion screen. (Oh et al., 2003) jeb protein is produced by somatic muscle precursors and is taken up by visceral muscle precursors. (Weiss et al., 2001) jeb is required for visceral mesoderm migration and differentiation. (Weiss et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136882 RefSeq (Proteins) • NP_610726 DDBJ / EMBL / GenBank • AAF58582 AAL25349 AAL30510 AAL30511 AB082046 AF425733 AF425734 AI293149 AQ034149 AW940617 AY060310 CZ479995 Entrez Gene - A searchable database of RefSeq genes. • 36295 UniProtKB/TrEMBL • Q95NU8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0086677 DRSC - Results from RNAi screens. • FBgn0086677 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30040-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36295 InParanoid A subset of ortholog calls from InParanoid. • XP_001897520.1 Brugia malayi (roundworm nematode) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/jellyby1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36295 modMine - Data generated by the modENCODE project. • FBgn0086677 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23736 ISCW023412 FBgn0231146 FBgn0223964 FBgn0208779 FBgn0196354 FBgn0186917 FBgn0175271 JGI_V11_263759 FBgn0075615 FBgn0154989 FBgn0141383 FBgn0128503 FBgn0114780 FBgn0089681 CPIJ013661 ACYPI24769 PHUM211900 GLEAN_01096
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG13180 (Bowler et al., 2006) CG13182   CG30040 (Keleman et al., 2009.8.5, Hazelett et al., 2009) jeb (Bazigou et al., 2007, Christensen and Cook, 2006.8.30, Bartolome and Charlesworth, 2006, Bazigou et al., 2007, Sandmann et al., 2007, Christensen et al., 2008.12.28, Liu et al., 2009, Wolfstetter et al., 2009, Cook and Cook, 2010.5.7, Hazelett et al., 2009) Jeb (Shirinian et al., 2007, Varshney and Palmer, 2006, Popichenko et al., 2007, Tong et al., 2011, Gouzi et al., 2011) l(2)k05644 (Spradling et al., 1999, ) l(2)SH0422
Name Synonym	jelly belly (Weiss, 2001.9.27, Weiss et al., 2001, Wolfstetter et al., 2009, Hazelett et al., 2009) Jelly belly (Bazigou et al., 2007, Tong et al., 2011, Rohrbough and Broadie, 2010) jellybelly (Vining and Andrew, 2004) jelly-belly   Jelly Belly (Shirinian et al., 2007, Varshney and Palmer, 2006) lethal (2) SH0422
Secondary FlyBase IDs
	FBgn0022161 FBgn0033681 FBgn0040761 FBgn0050040 FBgn0065792
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 )
Recent research papers ( 4 )
	Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Gouzi et al., 2011, PLoS Genet. 7(9): e1002281 The receptor tyrosine kinase alk controls neurofibromin functions in Drosophila growth and learning. [FBrf0216258] Tong et al., 2011, Neuron 71(3): 447--459 Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. [FBrf0214681] Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. [FBrf0211915] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...