Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jeb using the Feature Mapper tool.
jeb transcript is embryonically expressed in the ventral somatic mesoderm, adjacent to dorsal visceral mesoderm precursors. Somatic mesoderm expression is detected beginning at embryonic stage 8, and can no longer be detected at stage 12. At embryonic stage 10 jeb expressing cell clusters are interdigitated with bap-expressing cell clusters. At embryonic stage 11, jeb-expressing cells form continuous stripes that are adjacent and ventral to bap-expressing cells. At embryonic stage 16, jeb is expressed in a subset of neurons in the ventral nerve cord.
jeb is prdominantly expressed in the CNS and not in salivary gland, fat body, Malpighian tubule, or imaginal discs. High levels of jeb signal are detected in neurons and in the neurite-like structures that surround dorsomedial neurosecretory cells.
jeb is expressed at larval glutamergic neuromusclular junction synapses where it is primarily presynaptic and exhibits a localized punctate bouton expression pattern. It is strongly concentrated in smaller bouton subtypes, Is, II, and III and is heterogeneously and weakly expressed in type Ib boutons (with Alk). Extracellular jeb is localized at all bouton subtypes, predominantly closely associated with the presynaptic membrane. Concentrated jeb puncta are also observed a short distance from synaptic boutons. In mature embryos, jeb exhibited dense and extensive punctate localization along longitudinal neuropil axon tracts, and was also present in neuronal somata and segmental nerve trunks.
jeb protein is expressed in photoreceptor cells R1-8 from the third instar larval stage through adulthood. Expression is strong at 24 and 40 hours APF, decreasing at 50 hours APF. Strong pupal expression is observed in the R1-6 axons in the lamina, and R7-8 axons in the medulla at the 24 and 40 hours APF timepoints. The expression pattern in the developing visual system is complementay to that of Alk.
Secreted jeb protein is taken up by Alk-expressing cells in the visceral mesoderm.
jeb protein is secreted from cells in the somatic mesoderm and taken up by cells in the visceral mesoderm. Later in development, jeb is localized to a subset of axons in the ventral nerve cord, including the longitudinal connectives, and axons projecting to the periperal nervous system.
GBrowse - Visual display of RNA-Seq signalsView Dmel\jeb in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: jelly-belly CG13180 CG13182
jeb is required in R1-R6 cells to target their axons to the appropriate sets of target neurons in the lamina.
jeb protein is produced by somatic muscle precursors and is taken up by visceral muscle precursors.