Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\iav using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\iav in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
iav is required in larvae for choosing the preferred temperature of 17.5[o]C over 14[o]C through avoidance of 14[o]C, and this behaviour is mediated by increases in the number of turns and turning angles at this lower temperature.
Mutant flies fail to become sensitized to cocaine.
Mutants of iav show reductions in locomotor activity and exhibit poor mating success. Levels of the putative neurotransmitter octapamine are 10% that of wild type. In a courtship paradigm iav mutant males show an abnormal learning phenotype as a consequence of the octapamine deficiency.
Lower than normal octopamine levels, especially in extracts from adult heads with dopamine and norepinephrine levels apparently normal.