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Gene Dmel\iav

General Information
Symbol	Dmel\iav	Species	D. melanogaster
Name	inactive	Annotation symbol	CG4536
Feature type	protein_coding_gene	FlyBase ID	FBgn0086693
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-18.8
Cytogenetic map	6D3-6D3	Sequence location	X:6,708,151..6,712,189 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene inactive is referred to in FlyBase by the symbol Dmel\iav (CG4536, FBgn0086693). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium channel activity. There is experimental evidence that it is involved in the biological process: sensory perception of sound; response to heat; flight behavior; thermosensory behavior; thermotaxis; negative gravitaxis. 18 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Ion transport. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625881_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of iav. Gene sequence location is X:6708151..6712189.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	iav: inactive (J.C. Hall) iav1 noted (Kaplan, 1977) to be extremely inactive as adult, with normal external morphology; population of mutants remains quiet and spread out evenly in a container; will walk or fly when container disturbed, but settles into inactivity soon afterward. iav2 noted (Homyk and Sheppard, 1977) to be inactive and difficult to arouse for flight (and, when it does, seems to hover and fixate on objects); to jump and fly abnormally short distances; to exhibit slow running or climbing ability and optomotor response; to be debilitated after mechanical shock (especially in adults more than two weeks old). Gynandromorph analysis of iav2 adult behavioral impairments suggests primary focus could be neural (Homyk, 1977). Open-field activity tests of iav1 and iav2 (O'Dell and Burnet, 1988) showed both to exhibit reduced speed as well as amount of locomotion (the former meaning number of squares in the activity chambered visited/unit time, the latter the proportion of time spent moving); male activity levels higher than for females (also found for wild-type); lower than wildtype levels of activity at all ages between time of eclosion and approximately one-month; yet, unlike wild type, speed and amount of activity increase (in tests of iav2) in parallel between days 1 and 2 of adulthood (reaching a much lower than normal plateau). In tests of homozygous iav1 and iav2 females (with normal males), mating propensity reduced and courtship durations extended, though such females showed normal compositions of cuticular hydrocarbons and were highly attractive to courting males (O'Dell et al., 1989); mutant males with normal females exhibited slightly reduced mating success; mutant males crossed with mutant females had very low mating success rate. Lower than normal octopamine levels, especially in extracts from adult heads (O'Dell et al., 1987), with dopamine and norepinephrine levels apparently normal.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{iav-QF.P} References Petersen and Stowers, 2011, PLoS ONE 6(9): e24531 Matsuura et al., 2009, BMC Evol. Biol. 9: 228
FB2012_01	Sequence features BKN27960 HFA18363
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6D3-6D3   Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
Experimentally Determined Cytological Location
Cytogenetic map Notes References 6C5-6E4   Determined by deficiency and duplication mapping.   (Gong et al., 2004)
Experimentally Determined Recombination Data
Location	1-18.8
Left of (cM)
Right of (cM)
Notes	Based on mapping of iav1; iavhypoB-1 mapped to 1-20.7.
Gene Model & Products
Please see the GBrowse view of Dmel\iav for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) iav-RA FBtr0070969  NM_132125   3372   1123
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein iav-PA   FBpp0070930   124.7   1123   5.98     NP_572353   AAF46203
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ion transport (IPR005821) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46203   BF490258   EC055226   EW712793   EW712974   EY198991   FL502556   FL502822
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3W0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086693    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086693 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086693 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr  (111) embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086693 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr  111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    18 embryo 04-06hr    15 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    83 embryo 12-14hr    73 embryo 14-16hr    90 embryo 16-18hr    81 embryo 18-20hr    111 embryo 20-22hr    53 embryo 22-24hr    46 larva L1    36 larva L2    21 larva L3 12hr old    15 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    23 white prepupae new    24 white prepupae 12hr    34 white prepupae 24hr    31 pupae 2d postWPP    42 pupae 3d postWPP    29 pupae 4d postWPP    48 adult male 01day    44 adult male 05day    61 adult male 30day    86 adult female 01day    31 adult female 05day    12 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086693    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086693 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086693 expression level Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086693 expression level Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.75 Larval Midgut    3.6 Larval Hindgut    2.2 Larval Malpighian Tubules    8.3 Larval Fat Body    7.4 Larval Salivary Gland    7.5 Larval Trachea    1.9 Larval Carcass    2.3 Adult Head no informative data Adult Eye    3.675 Adult Brain    6.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    8.4 Adult Midgut    6.4 Adult Hindgut    6.2 Adult Malpighian Tubules    8.2 Adult Fat Body    5.8 Adult Salivary Gland no informative data Adult Heart    3.975 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    4 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    9.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    3.675   NA  Brain    6.9   3.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    8.4   3.6  Midgut    6.4   2.2  Hindgut    6.2   8.3  Malpighian Tubules    8.2   7.4  Fat Body    5.8   7.5  Salivary Gland    no informative data   NA  Heart    3.975   1.9  Trachea    NA   NA  VirginFemale Spermatheca    6.6   NA  InseminatedFemale Spermatheca    2.9   NA  Ovary    4   NA  Testis    1.9   NA  Male Accessory Gland    no informative data   2.3  Carcass    9.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4536-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 iavGD3260 Other Phenotypes Allele auditory perception defective | female (with iav1) iav3621 auditory perception defective | female (with iav3621) iav1 auditory perception defective | male iav1 iav3621 behavior defective iav1 chemical sensitive iav1 iavhypoB-2 courtship behavior defective | female iav1 iavhypoB-2 heat stress response defective iavhypoB-1 hypoactive | adult stage iav1 iavhypoB-2 locomotor behavior defective | larval stage iav1 mating defective iav1 iavhypoB-2 short lived iav1 iavhypoB-2 thermotaxis behavior defective | third instar larval stage iav1 iav3621 thermotaxis behavior defective | third instar larval stage (with Df(1)pod1Δ17) iav1 iav3621 Phenotype manifest in Allele
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of iav Class Mutagen Stocks Known lesion iav1 hypomorphic allele - genetic evidence spontaneous 2 Yes iav3621 ethyl methanesulfonate 1 Yes iavhypoB-1 ethyl methanesulfonate 0 -- iavhypoB-2 ethyl methanesulfonate 0 -- iavhypoB-3 ethyl methanesulfonate 0 -- iavN+ 0 -- iavN- 0 -- iavS+ 0 -- iavS- 0 -- iavunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of iav Class Mutagen Stocks Known lesion iavGD3260 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes iavJF01904 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes iavKK107960 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes iav+t9.2 in vitro construct - genomic fragment 0 Yes iavCterm.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes iavdsRNA.cRa in vitro construct - RNAi 0 Yes iavNterm.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes iavScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)pod1Δ17 (Rothenberg et al., 2004) Df(1)pod1Δ96 (Rothenberg et al., 2004) Df(1)pod1Δ291 (Rothenberg et al., 2004)
Duplicated in	Tp(1;3)sn13a1 (Gong et al., 2004)
Not disrupted in	Df(1)Sxl-bt (Gong et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3260} NA P{KK107960} NA P{TRiP.JF01904} NA P{UAS-iav.K} NA characterization construct P{iav-GFP.Cterm} NA P{iav-GFP.Nterm} NA P{iav-QF.P} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
flight behavior inferred from mutant phenotype (Homyk and Sheppard, 1977) negative gravitaxis inferred from mutant phenotype (Sun et al., 2009) response to heat inferred from mutant phenotype (Chentsova et al., 2002) sensory perception of sound inferred from mutant phenotype (Gong et al., 2004, Gopfert et al., 2006, Sun et al., 2009) thermosensory behavior inferred from mutant phenotype (Kwon et al., 2010) thermotaxis inferred from mutant phenotype (Kwon et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
calcium channel activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) inferred from sequence or structural similarity with EMBL:AJ133128 (FlyBase, 1992-)
Biological Process
CV term Evidence References
behavioral response to cocaine non-traceable author statement (Rothenfluh and Heberlein, 2002) calcium ion transport inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ion transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-) sensory perception of smell inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) transmembrane transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions iav allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0086693 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31621
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA18240
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009258-PA Aedes aegypti (mosquito) AGAP000413-PA Anopheles gambiae (mosquito) XP_001121881.1 Apis mellifera (honey bee) XP_001950096.1 Acyrthosiphon pisum (pea aphid) 105348 Branchiostoma floridae (lancelet) 76035 Branchiostoma floridae (lancelet) BGIBMGA004308-PA Bombyx mori (silk worm) ENSBTAP00000033351 Bos taurus (bovine) CBP03428 Caenorhabditis briggsae (nematode) CE20445 Caenorhabditis elegans (worm) CPIJ014201 Culex pipens (mosquito) RP04018 Caenorhabditis remanei (nematode) ENSCSAVP00000018669 Ciona savignyi (sedentary tunicate) 175814 Capitella spl (polychaete worm) 41236 Daphnia pulex (daphnia) 77785 Hypsipyla robusta (cedar shoot borer) 132455 Lottia gigantea (owl limpet) 10538 Nematostella vectensis (starlet anemone) XP_001602588.1 Nasonia vitripennis (wasp) PHUM002808-PA Pediculus humanus (human body louse) XP_789784.2 Strongylocentrotus purpuratus (purple sea urchin) 62262 Trichoplax adhaerens (metazoa) ENSTNIP00000011128 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000011373 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000018971 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023158 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012743 Xenopus tropicalis (frog) ENSXETP00000049441 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13362 LH15510 FBgn0234267 FBgn0212285 FBgn0204067 FBgn0167470 JGI_V11_41236 FBgn0078247 FBgn0164335 FBgn0144380 FBgn0131905 FBgn0111815 FBgn0096352 CPIJ014201 BGIBMGA004308 ACYPI004017 GB13007 AGAP000413 AAEL009258 PB25508 PB25509 PHUM581890 GLEAN_12368 GLEAN_12369
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	6029 iav1 25865 y1 v1; P{TRiP.JF01904}attP2 24768 iav3621/C(1)DX, y1 f1
Kyoto	101174 iav1
VDRC	v100701 P{KK107960}VIE-260B v7126 w1118; P{GD3260}v7126 v7128 w1118; P{GD3260}v7128
Genomic Clones ( 2 )
	BACR04D11 BACR48O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT26581
Other clones	DMG1-chrX.7.094.a DMG2-chrX.7.077.a.1 DMG4-chrX.13.001.pred.a EC055226
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31621
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: iav CG4536 (Gong et al., 2004)
Additional comments
Other Comments
	iav is required in larvae for choosing the preferred temperature of 17.5[o]C over 14[o]C through avoidance of 14[o]C, and this behaviour is mediated by increases in the number of turns and turning angles at this lower temperature. (Kwon et al., 2010) Larvae simultaneously injected with dsRNAs against iav and nan show normal thermotactic behaviour. (Rosenzweig et al., 2005) Mutant flies fail to become sensitized to cocaine. (McClung and Hirsh, 1999) Mutants of iav show reductions in locomotor activity and exhibit poor mating success. Levels of the putative neurotransmitter octapamine are 10% that of wild type. In a courtship paradigm iav mutant males show an abnormal learning phenotype as a consequence of the octapamine deficiency. (O'Dell, 1993) Lower than normal octopamine levels, especially in extracts from adult heads with dopamine and norepinephrine levels apparently normal. (O'Dell et al., 1987) Allelism of iav1 to iavhypoB-1 shown by O'Dell and Burnet (1986) in open field tests of heterozygotes; they also note that both mutations are recessive.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132125 RefSeq (Proteins) • NP_572353 DDBJ / EMBL / GenBank • AAF46203 Entrez Gene - A searchable database of RefSeq genes. • 31621 UniProtKB/TrEMBL • Q9W3W0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ion transport (IPR005821) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0086693 DRSC - Results from RNAi screens. • FBgn0086693 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4536-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31621 InParanoid A subset of ortholog calls from InParanoid. • AAEL009258-PA Aedes aegypti (mosquito) AGAP000413-PA Anopheles gambiae (mosquito) XP_001121881.1 Apis mellifera (honey bee) XP_001950096.1 Acyrthosiphon pisum (pea aphid) 105348 Branchiostoma floridae (lancelet) 76035 Branchiostoma floridae (lancelet) BGIBMGA004308-PA Bombyx mori (silk worm) ENSBTAP00000033351 Bos taurus (bovine) CBP03428 Caenorhabditis briggsae (nematode) CE20445 Caenorhabditis elegans (worm) CPIJ014201 Culex pipens (mosquito) RP04018 Caenorhabditis remanei (nematode) ENSCSAVP00000018669 Ciona savignyi (sedentary tunicate) 175814 Capitella spl (polychaete worm) 41236 Daphnia pulex (daphnia) 77785 Hypsipyla robusta (cedar shoot borer) 132455 Lottia gigantea (owl limpet) 10538 Nematostella vectensis (starlet anemone) XP_001602588.1 Nasonia vitripennis (wasp) PHUM002808-PA Pediculus humanus (human body louse) XP_789784.2 Strongylocentrotus purpuratus (purple sea urchin) 62262 Trichoplax adhaerens (metazoa) ENSTNIP00000011128 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000011373 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000018971 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023158 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012743 Xenopus tropicalis (frog) ENSXETP00000049441 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31621 modMine - Data generated by the modENCODE project. • FBgn0086693 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13362 LH15510 FBgn0234267 FBgn0212285 FBgn0204067 FBgn0167470 JGI_V11_41236 FBgn0078247 FBgn0164335 FBgn0144380 FBgn0131905 FBgn0111815 FBgn0096352 CPIJ014201 BGIBMGA004308 ACYPI004017 GB13007 AGAP000413 AAEL009258 PB25508 PB25509 PHUM581890 GLEAN_12368 GLEAN_12369
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG4536 (Mutai and Heller, 2003, King et al., 2002.9.23, McPartland et al., 2006, Roos et al., 2005, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5) CT14708 (Littleton and Ganetzky, 2000) DmIav (Matsuura et al., 2009) hypoB   iav (Gong et al., 2004, Lumpkin, 2007, McClung and Hirsh, 1999, Saraswati et al., 2004, Gopfert et al., 2006, Ruan and Wu, 2008, Lee et al., 2008, Lee et al., 2008, Anaka et al., 2008, Sun et al., 2009, Kwon et al., 2008, Morey et al., 2008, Lee et al., 2010, Kim et al., 2010, Kwon et al., 2010, Roshina and Pasyukova, 2007, Cachero et al., 2011, Wasbrough et al., 2010, Petersen and Stowers, 2011) IAV (Bechstedt et al., 2010) TRPV (Caterina and Montell, 2005)
Name Synonym	inactive (Lumpkin, 2007, Lee et al., 2008, Cachero et al., 2011) Inactive (Lee et al., 2010, Kwon et al., 2010)
Secondary FlyBase IDs
	FBgn0001246 FBgn0029904
References ( 72 )
Generate a list of	All references relating to this gene ( 72 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 5 ) Review  ( 11 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Petersen and Stowers, 2011, PLoS ONE 6(9): e24531 A Gateway MultiSite Recombination Cloning Toolkit. [FBrf0215584] Bechstedt et al., 2010, Nat. Commun. 1: 11 A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. [FBrf0212106] Kim et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(18): 8440--8445 Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. [FBrf0210738] Kwon et al., 2010, J. Neurosci. 30(31): 10465--10471 Fine Thermotactic Discrimination between the Optimal and Slightly Cooler Temperatures via a TRPV Channel in Chordotonal Neurons. [FBrf0211446] Kwon et al., 2010, Curr. Biol. 20(18): 1672--1678 Drosophila TRPA1 Channel Is Required to Avoid the Naturally Occurring Insect Repellent Citronellal. [FBrf0211878] Lee et al., 2010, PLoS ONE 5(6): e11012 Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. [FBrf0210994] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...