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General Information
Symbol
Dmel\iav
Species
D. melanogaster
Name
inactive
Annotation Symbol
CG4536
Feature Type
FlyBase ID
FBgn0086693
Gene Model Status
Stock Availability
Gene Snapshot
inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound. [Date last reviewed: 2019-08-01]
Also Known As

TRPV

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:6,813,978..6,818,156 [+]
Recombination map

1-18

RefSeq locus
NC_004354 REGION:6813978..6818156
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000832860
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
inferred from biological aspect of ancestor with PANTHER:PTN000061616
(assigned by GO_Central )
Biological Process (14 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000061616
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
inferred from sequence or structural similarity
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
inferred from biological aspect of ancestor with PANTHER:PTN000061616
(assigned by GO_Central )
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
TRANSIENT RECEPTOR POTENTIAL CHANNELS -
The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
iav: inactive (J.C. Hall)
iav1 noted (Kaplan, 1977) to be extremely inactive as adult, with normal external morphology; population of mutants remains quiet and spread out evenly in a container; will walk or fly when container disturbed, but settles into inactivity soon afterward. iav2 noted (Homyk and Sheppard, 1977) to be inactive and difficult to arouse for flight (and, when it does, seems to hover and fixate on objects); to jump and fly abnormally short distances; to exhibit slow running or climbing ability and optomotor response; to be debilitated after mechanical shock (especially in adults more than two weeks old). Gynandromorph analysis of iav2 adult behavioral impairments suggests primary focus could be neural (Homyk, 1977). Open-field activity tests of iav1 and iav2 (O'Dell and Burnet, 1988) showed both to exhibit reduced speed as well as amount of locomotion (the former meaning number of squares in the activity chambered visited/unit time, the latter the proportion of time spent moving); male activity levels higher than for females (also found for wild-type); lower than wildtype levels of activity at all ages between time of eclosion and approximately one-month; yet, unlike wild type, speed and amount of activity increase (in tests of iav2) in parallel between days 1 and 2 of adulthood (reaching a much lower than normal plateau). In tests of homozygous iav1 and iav2 females (with normal males), mating propensity reduced and courtship durations extended, though such females showed normal compositions of cuticular hydrocarbons and were highly attractive to courting males (O'Dell et al., 1989); mutant males with normal females exhibited slightly reduced mating success; mutant males crossed with mutant females had very low mating success rate. Lower than normal octopamine levels, especially in extracts from adult heads (O'Dell et al., 1987), with dopamine and norepinephrine levels apparently normal.
Summary (Interactive Fly)

transient receptor potential vanilloid channel - expressed in chordotonal neurons where it is involved in temperature preference - expressed in antenna were it is involved in hearing

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\iav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070969
3512
1123
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070930
124.7
1123
5.98
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\iav using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{iav-GAL4.K}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GAL4.U}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GFP.597}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GFP.Cterm}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-QF.P}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: PBac{iav-GAL4.P}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\iav in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of iav
Transgenic constructs containing regulatory region of iav
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
No
8 of 15
No
No
5 of 15
No
No
1  
5 of 15
No
No
5 of 15
No
No
6  
4 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
No
8 of 15
No
No
5 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
Rattus norvegicus (Norway rat) (7)
8 of 13
Yes
No
8 of 13
Yes
No
5 of 13
No
No
5 of 13
No
No
4 of 13
No
No
4 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (17)
6 of 12
Yes
No
4 of 12
No
No
4 of 12
No
No
4 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (4)
6 of 15
Yes
No
5 of 15
No
No
5 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
13 of 15
Yes
Yes
5 of 15
No
No
4 of 15
No
No
3 of 15
No
No
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901OW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01FK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01DP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0250 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
6 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-18

    Cytogenetic map
    Sequence location
    X:6,813,978..6,818,156 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    6D3-6D3
    Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Determined by deficiency and duplication mapping.
    Experimentally Determined Recombination Data
    Location

    1-18.8

    Left of (cM)
    Right of (cM)
    Notes

    Based on mapping of iav1; iavhypoB-1 mapped to 1-20.7.

    Stocks and Reagents
    Stocks (7)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (4)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: iav CG4536

            Additional comments

            Source for merge of: iav hypoB

            Other Comments

            iav is required in larvae for choosing the preferred temperature of 17.5[o]C over 14[o]C through avoidance of 14[o]C, and this behaviour is mediated by increases in the number of turns and turning angles at this lower temperature.

            Larvae simultaneously injected with dsRNAs against iav and nan show normal thermotactic behaviour.

            Mutant flies fail to become sensitized to cocaine.

            Mutants of iav show reductions in locomotor activity and exhibit poor mating success. Levels of the putative neurotransmitter octapamine are 10% that of wild type. In a courtship paradigm iav mutant males show an abnormal learning phenotype as a consequence of the octapamine deficiency.

            Lower than normal octopamine levels, especially in extracts from adult heads with dopamine and norepinephrine levels apparently normal.

            Allelism of iav1 to iavhypoB-1 shown by O'Dell and Burnet (1986) in open field tests of heterozygotes; they also note that both mutations are recessive.

            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 27 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (12)
            Reported As
            Symbol Synonym
            hypoB
            Secondary FlyBase IDs
            • FBgn0029904
            • FBgn0001246
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (152)