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Gene Dmel\frtz

General Information
Symbol	Dmel\frtz	Species	D. melanogaster
Name	fritz	Annotation symbol	CG17657
Feature type	protein_coding_gene	FlyBase ID	FBgn0086698
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22B1-22B1	Sequence location	2L:1,711,302..1,715,851 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene fritz is referred to in FlyBase by the symbol Dmel\frtz (CG17657, FBgn0086698). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing hair site selection; establishment of planar polarity. 17 alleles are reported. The phenotypes of these alleles are annotated with: leg sensillum; leg; macrochaeta; denticle row; tarsal segment 4; microchaeta; tarsal segment 3; bract; wing hair; triple row. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein of unknown function DUF3312; WD40 repeat; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630378_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of frtz. Gene sequence location is 2L:1711302..1715851.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22B1-22B1   Limits computationally determined from genome sequence between P{PZ}l(2)0411104111 and P{lacW}CG17646k11021
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\frtz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) frtz-RA FBtr0077911  NM_134770   3601   951 frtz-RB FBtr0333544  NM_001272950   3303   951 frtz-RD FBtr0333545  NM_001272951   3586   946
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein frtz-PA   FBpp0077577   106.1   951   8.42     NP_608614   AAF51346 frtz-PB   FBpp0305724   106.1   951   8.42     NP_001259879   AGB92416 frtz-PD   FBpp0305725   105.5   946   8.42     NP_001259880   AGB92417
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) Protein of unknown function DUF3312 (IPR024511) WD40/YVTN repeat-like-containing domain (IPR015943)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141928   AE014134 AAF51346   AE014134 AGB92416   AE014134 AGB92417   AX093981   BI237832   BI606201   BT004832 AAO45188   CO267743   CO267771   CO291793   CO316340   CO317708   CO343847   EC066649   EC068826   EC084657   EC210609   EC252502
UniProtKB/Swiss-Prot	Q9VQ36
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.225 Larval Midgut    52.1 Larval Hindgut    68 Larval Malpighian Tubules    56.7 Larval Fat Body    54.3 Larval Salivary Gland    90.2 Larval Trachea    55.35 Larval Carcass    52.35 Adult Head    64.7 Adult Eye    38.275 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    34.1 Adult Crop    89.1 Adult Midgut    51.9 Adult Hindgut    68.5 Adult Malpighian Tubules    80.2 Adult Fat Body    60.9 Adult Salivary Gland    120.2 Adult Heart    41.575 Adult VirginFemale Spermatheca    65.6 Adult InseminatedFemale Spermatheca    68.6 Adult Ovary    163.7 Adult Testis    17.1 Adult Male Accessory Gland    53.5 Adult Carcass    87 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    64.7   NA  Eye    38.275   NA  Brain    30   59.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    34.1   NA  Crop    89.1   52.1  Midgut    51.9   68  Hindgut    68.5   56.7  Malpighian Tubules    80.2   54.3  Fat Body    60.9   90.2  Salivary Gland    120.2   NA  Heart    41.575   55.35  Trachea    NA   NA  VirginFemale Spermatheca    65.6   NA  InseminatedFemale Spermatheca    68.6   NA  Ovary    163.7   NA  Testis    17.1   NA  Male Accessory Gland    53.5   52.35  Carcass    87 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    6 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    10 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    3 embryonic S1    6 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086698 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17657-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 frtzGD9437 viable | reduced frtz7 Sterility Allele fertile | reduced frtz7 Other Phenotypes Allele planar polarity defective frtz1 frtzunspecified planar polarity defective, with Scer\GAL4pnr-MD237 frtzGD9437 planar polarity defective | cell autonomous | recessive | somatic clone frtz33 planar polarity defective | heat sensitive frtz3 planar polarity defective | recessive frtz1 planar polarity defective | recessive | cold sensitive frtz33 visible frtz1 frtzunspecified visible | cell autonomous | recessive | somatic clone frtz33 visible | heat sensitive frtz3 visible | recessive frtz1 visible | recessive | cold sensitive frtz33 Phenotype manifest in Allele bract frtzunspecified denticle row frtz33 joint | ectopic frtzunspecified leg frtzunspecified leg sensillum frtzunspecified macrochaeta frtz33 microchaeta frtz33 tarsal segment 3 frtzunspecified tarsal segment 4 frtzunspecified triple row frtz1 wing | pupal stage frtz1 wing hair frtz1 wing hair | cell autonomous | somatic clone frtz33 wing hair | cell autonomous | somatic clone | supernumerary frtz33 wing hair | cold sensitive frtz33 wing hair | heat sensitive frtz3 wing hair | supernumerary frtz2 frtz33 wing hair | supernumerary | heat sensitive frtz3
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of frtz Class Mutagen Stocks Known lesion frtz1 ethyl methanesulfonate 2 Yes frtzKG08171 2 -- frtz3 heat sensitive hypomorphic allele - genetic evidence X ray 1 Yes frtzNP2148 1 -- frtz26 ethyl methanesulfonate 0 -- frtz27 X ray 0 Yes frtz28 X ray 0 Yes frtz29 X ray 0 Yes frtz2 0 Yes frtz30 X ray 0 Yes frtz33 X ray 0 Yes frtz7 X ray 0 Yes frtzKG04255a 0 -- frtzunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of frtz Class Mutagen Stocks Known lesion frtzGD9437 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes frtzKK101672 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes frtzNIG.17657R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)dp-79b (Collier et al., 2005) Df(2L)Exel6005 (Ryder, 2004.4.26) Df(2L)F.1 (Collier et al., 2005) Df(2L)frtz11 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz14 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz17 (Roote, 1999.11.22) Df(2L)frtz19 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz24 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz25 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz7 (Collier et al., 2005) Df(2L)S2 (Collier et al., 2005)
Partially disrupted in	Df(2L)frtz7 (Collier et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9437} NA P{KK101672} NA P{NIG.17657R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}frtzNP2148 No miscellaneous insertions P{SUPor-P}frtzKG04255a NA P{SUPor-P}frtzKG08171 NA PBac{WH}mRpL48f08082 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
establishment of planar polarity inferred from mutant phenotype (Collier et al., 2002) imaginal disc-derived wing hair site selection inferred from mutant phenotype (Collier et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
frtz - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) frtz - HIP-R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) frtz - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) frtz - mask anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) frtz - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions frtz allele Gene References frtz3 fy (Collier et al., 2005) in (Collier et al., 2005) unspecified sha (Ren et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59589 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086698 DroID - A comprehensive database of gene and protein interactions. • FBgn0086698 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33349
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PG6KB Dipteran inclusive ortholog search EOG6K9BM9 Insect inclusive ortholog search EOG6CRJV1 Arthropod inclusive ortholog search EOG6S1RP4 Metazoa inclusive ortholog search EOG6KDKCW
Orthologs in Drosophila Species (EOG6PG6KB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\frtz     Drosophila sechellia   Dsec\GM16600     Drosophila sechellia   Dsec\GM13573     Drosophila erecta   Dere\GG24581     Drosophila yakuba   Dyak\GE15489     Drosophila ananassae   Dana\GF24395     Drosophila pseudoobscura pseudoobscura   Dpse\GA14599     Drosophila persimilis   Dper\GL19344     Drosophila willistoni   Dwil\GK14937     Drosophila virilis   Dvir\GJ17221     Drosophila mojavensis   Dmoj\GI16975     Drosophila grimshawi   Dgri\GH11480
Orthologs in non-Drosophila Dipterans (EOG6K9BM9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010795   Anopheles gambiae Malaria mosquito  Agam\AGAP002252   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013527
Orthologs in non-Dipteran Insects (EOG6CRJV1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40363   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006060   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20618   Atta cephalotes Leafcutter ant  Acep\ACEP20316   Atta cephalotes Leafcutter ant  Acep\ACEP12846   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18836   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19612   Linepithema humile Argentine ant  Lhum\LH24280   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25613   Solenopsis invicta Red fire ant  Sinv\SINV17544   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006862   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07658-OG5698
Orthologs in non-Insect Arthropods (EOG6S1RP4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ctaA   Ixodes scapularis Deer tick  Isca\ISCW021937
Orthologs in non-Arthropod Metazoa (EOG6KDKCW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003903gn   Danio rerio Zebrafish  Drer\ENSDARG00000074590   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000013020   Gallus gallus Domestic chicken  Ggal\WDPCP   Mus musculus House mouse  Mmus\Wdpcp   Rattus norvegicus Norway rat  Rnor\Wdpcp   Homo sapiens Human  Hsap\WDPCP
Human Orthologs (1)
Gene OMIM HGNC Hsap\WDPCP
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	5455 frtz1 bw1 5456 frtz3 P{neoFRT}42D cn1/CyO 14939 y1; P{SUPor-P}frtzKG08171/CyO; ry506
Kyoto	108248 frtz1 bw1 104105 w*; P{GawB}frtzNP2148 / CyO 111652 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}frtzKG08171 P{neoFRT}40A/CyO y+
VDRC	v103611 P{KK101672}VIE-260B v40088 w1118; P{GD9437}v40088
Genomic Clones ( 1 )
	BACR19B15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH72421
Other clones	DPiM_RH72421
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE34143
Other clones	EK151645 EK151814 EK198307 EK264601 EK268838 EP18221
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086698 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33349
Antibody Information
	polyclonal (Strutt and Warrington, 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG17657 anon-WO0118547.105 (FlyBase, 1996-) Source for merge of: frtz CG17657 (Collier et al., 2005)
Additional comments	Source for merge of CG17657 anon-WO0118547.105 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	frtz is a planar cell polarity (PCP) effector gene that functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites. (Collier et al., 2005) Area matching Drosophila EST AA141928. (Davies, 2001.3.15) A tissue polarity gene. (Collier et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134770 NM_001272950 NM_001272951 RefSeq (Proteins) • NP_608614 NP_001259879 NP_001259880 DDBJ / EMBL / GenBank • AA141928 AAF51346 AAO45188 AGB92416 AGB92417 AX093981 BI606201 BT004832 Entrez Gene - A searchable database of RefSeq genes. • 33349 UniProtKB/Swiss-Prot • Q9VQ36
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) Protein of unknown function DUF3312 (IPR024511) WD40/YVTN repeat-like-containing domain (IPR015943)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59589 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086698 DroID - A comprehensive database of gene and protein interactions. • FBgn0086698 DRSC - Results from RNAi screens. • FBgn0086698 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086698 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17657-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086698 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 450708 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33349 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33349 modMine - Data generated by the modENCODE project. • FBgn0086698
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0118547.105   CG17657 (Collier et al., 2005, Stark et al., 2003, Giot et al., 2003, FlyBase, 1996-, Davies et al., 2001, Deloger et al., 2009, Lipatov et al., 2005, Keleman et al., 2009.8.5) fritz (Ren et al., 2006) frtz (Strutt and Warrington, 2008, Pataki et al., 2010, Lu et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	fritz (Chanut-Delalande et al., 2006, Collier et al., 1997, Yan et al., 2007, Mihaly et al., 2007, Strutt and Warrington, 2008, Pataki et al., 2010, Lu et al., 2010)
Secondary FlyBase IDs
	FBgn0020302 FBgn0031358 FBgn0062241
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) Patent  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...