FB2021_02, released April 13, 2021

Gene: Dmel\frtz

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General Information
Symbol
Dmel\frtz
Species
D. melanogaster
Name
fritz
Annotation Symbol
CG17657
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086698
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
fritz (frtz) encodes a cytoplasmic protein that functions as a planar polarity effector as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity. frtz protein directly binds to the product of in and accumulates on the proximal side of wing cells. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
22B1-22B1
Sequence location
2L:1,711,302..1,715,851 [-]
Recombination map
2-3
RefSeq locus
NT_033779 REGION:1711302..1715851
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in imaginal disc-derived wing hair site selection
inferred from mutant phenotype
(Collier et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cilium organization
inferred from biological aspect of ancestor with PANTHER:PTN001007408
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in establishment of protein localization
inferred from biological aspect of ancestor with PANTHER:PTN001007408
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in nervous system development
inferred from biological aspect of ancestor with PANTHER:PTN001007408
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in axonemal basal plate
inferred from biological aspect of ancestor with PANTHER:PTN001007408
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the WD repeat fritz family. (Q9VQ36)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
fritz (frtz) encodes a cytoplasmic protein that functions as a planar polarity effector as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity. frtz protein directly binds to the product of in and accumulates on the proximal side of wing cells. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Functions cell autonomously to regulate wing cell hair polarity and number.
(UniProt, Q9VQ36)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\frtz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
frtz-RA
FBtr0077911
NM_134770
3601
951
frtz-RB
FBtr0333544
NM_001272950
3303
951
frtz-RD
FBtr0333545
NM_001272951
3586
946
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
frtz-PA
FBpp0077577
106.1
951
8.42
NP_608614
AAF51346
frtz-PB
FBpp0305724
106.1
951
8.42
NP_001259879
AGB92416
frtz-PD
FBpp0305725
105.5
946
8.42
NP_001259880
AGB92417
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

951 aa isoforms: frtz-PA, frtz-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\frtz using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\frtz in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of frtz
Transgenic constructs containing regulatory region of frtz
Aberrations (Deficiencies and Duplications) ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
semi-fertile
Other Phenotypes
Allele
abnormal planar polarity
abnormal planar polarity, with Scer\GAL4pnr-MD237
abnormal planar polarity, with Scer\GAL4ptc.PU
abnormal planar polarity | adult stage
abnormal planar polarity | cell autonomous | recessive | somatic clone
abnormal planar polarity | heat sensitive
abnormal planar polarity | recessive
abnormal planar polarity | recessive | cold sensitive
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible
visible (with Df(2L)Exel6005)
visible | adult stage
visible | cell autonomous | recessive | somatic clone
visible | heat sensitive
visible | recessive
visible | recessive | cold sensitive
Phenotype manifest in
Allele
abdominal sternite bristle
bract
chaeta (with Df(2L)Exel6005)
denticle row
joint | ectopic
leg
leg sensillum
macrochaeta
microchaeta
tarsal segment 3
tarsal segment 4
triple row
wing | pupal stage
wing hair
wing hair, with Scer\GAL4ptc.PU
wing hair | cell autonomous | somatic clone
wing hair | cell autonomous | somatic clone | increased number
wing hair | cold sensitive
wing hair | heat sensitive
wing hair | increased number
wing hair | increased number | heat sensitive
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\WDPCP
13 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Wdpcp
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Wdpcp
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\wdpcp
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\wdpcp
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901YK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000762
Drosophila simulans
Dsim\GD28664
Drosophila sechellia
Dsec\GM16600
Drosophila sechellia
Dsec\GM13573
Drosophila erecta
Dere\GG24581
Drosophila yakuba
Dyak\GE15489
Drosophila ananassae
Dana\GF24395
Drosophila pseudoobscura pseudoobscura
Dpse\GA14599
Drosophila persimilis
Dper\GL19344
Drosophila willistoni
Dwil\GK14937
Drosophila virilis
Dvir\GJ17221
Drosophila mojavensis
Dmoj\GI16975
Drosophila grimshawi
Dgri\GH11480
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500X5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012438
Glossina morsitans
Tsetse fly
Gmor\GMOY001657
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06822
Mayetiola destructor
Hessian fly
Mdes\Mdes015316
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010795
Anopheles darlingi
American malaria mosquito
Adar\ADAC009559
Anopheles gambiae
Malaria mosquito
Agam\AGAP002252
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013527
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03P0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\3488635028
Apis mellifera
Western honey bee
Amel\GB40363
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23717
Bombus terrestris
Buff-tailed bumblebee
Bter\15207202
Linepithema humile
Argentine ant
Lhum\LH24280
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0014ed
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006060
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04901
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07658-OG5698
Rhodnius prolixus
Kissing bug
Rpro\RPRC005324
Cimex lectularius
Bed bug
Clec\CLEC008155
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006862
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10570
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02M2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012916
Ixodes scapularis
Black-legged tick
Isca\ISCW021937
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75724.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75725.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g10730
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117600
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03ZZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2209
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009181
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012118
Gallus gallus
Domestic chicken
Ggal\WDPCP
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WDPCP; WD repeat containing planar cell polarity effector
    13 of 15
    613580
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    RNA-RNA
    Physical Interaction
    Assay
    References
    frtz - mir-312
    fluorescence technology
    (Schertel et al., 2012)
    frtz - mir-92a
    fluorescence technology
    (Schertel et al., 2012)
    frtz - mir-92b
    fluorescence technology
    (Schertel et al., 2012)
    protein-protein
    Physical Interaction
    Assay
    References
    frtz - dsh
    two hybrid, anti tag coimmunoprecipitation, western blot
    (Wang et al., 2017)
    frtz - fy
    anti bait coimmunoprecipitation, anti tag western blot
    (Wang et al., 2014)
    frtz - in
    anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, two hybrid
    (Wang et al., 2014)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    frtz
    suppressible
    frtz::pk
    (Wang et al., 2017)
    frtz
    enhanceable
    fy
    (Collier et al., 2005)
    frtz
    enhanceable
    in
    (Collier et al., 2005)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    cmb
    enhanceable
    frtz
    (Fagan et al., 2014)
    fy
    enhanceable
    frtz
    (Collier et al., 2005)
    in
    suppressible
    frtz
    (Wang et al., 2017, Wang et al., 2014)
    in
    enhanceable
    frtz
    (Collier et al., 2005)
    Rab23
    enhanceable
    frtz
    (Pataki et al., 2010)
    sha
    enhanceable
    frtz
    (Ren et al., 2006)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-3
    Cytogenetic map
    22B1-22B1
    Sequence location
    2L:1,711,302..1,715,851 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    22B1-22B1
    Limits computationally determined from genome sequence between P{PZ}l(2)0411104111 and P{lacW}CG17646k11021
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-3

    (FlyBase, 2016)

    2-3.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (9)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Strutt and Warrington, 2008)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: frtz CG17657

    (Collier et al., 2005)

    Source for merge of: CG17657 anon-WO0118547.105

    (FlyBase, 1996-)
    Additional comments

    Source for merge of CG17657 anon-WO0118547.105 was sequence comparison ( date:051113 ).

    (FlyBase, 1996-)
    Other Comments

    frtz is a planar cell polarity (PCP) effector gene that functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites.

    (Collier et al., 2005)

    Area matching Drosophila EST AA141928.

    (Davies, 2001.3.15)

    A tissue polarity gene.

    (Collier et al., 1997)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 41 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (5)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (69)