ABCE1
Please see the JBrowse view of Dmel\pix for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Interacts with components of eIF3 complex, namely eIF3a, eIF3j, eIF3b, eIF3c and eIF3i (PubMed:17392269). Associates with the 40S ribosome subunit in an ATP-dependent manner and independently from the presence of the eIF3 complex (PubMed:17392269). Forms a complex with Git and Pak; the interaction with Pak may be mediated by pix/dPIX (PubMed:18996366).
Ubiquitinated by Cnot4 (PubMed:29861391). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (PubMed:29861391).
The ABC transporter 2 domain is necessary and sufficient for association to the 40S ribosome subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pix using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\pix in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show significantly lower levels of global translation within 2 days. Additionally, cell number is reduced and an increased proportion of cells accumulate in G1.
Identification: In a screen for dominant modifiers of a small wing phenotype caused by expression of a kinase dead form of Pi3K92E in the developing wing.
Flies homozygous for weak hypomorphic mutations are viable, show developmental delay and are either normal in size or display a 10 percent reduction in body size. Cells homozygous for the hypomorphic mutations are eliminated when surrounded by wild type cells in mosaic animals.
Identified with: GH18088.5prime <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.
Source for merge of: pixie CG5651
Gene is named "pixie" owing to the small body/wing phenotypes produced by mutations in this gene when in trans to other "E3-c" mutations or when heterozygous in a Pi3K92ED954A.Scer\UAS.T:Hsap\MYC ; Scer\GAL4Bx-MS1096 background.
