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Gene Dmel\cbs

General Information
Symbol	Dmel\cbs	Species	D. melanogaster
Name	centrosomin's beautiful sister	Annotation symbol	CG4840
Feature type	protein_coding_gene	FlyBase ID	FBgn0086757
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	dem
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50A9-50A9	Sequence location	2R:9,338,169..9,340,898 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene centrosomin's beautiful sister is referred to in FlyBase by the symbol Dmel\cbs (CG4840, FBgn0086757). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: centrosome cycle. 6 alleles are reported. The phenotypes of these alleles are annotated with: syncytial blastoderm embryo; centrosome; stage 5 embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: GRIP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval fat body, adult salivary gland, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1625589_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cbs. Gene sequence location is 2R:9338169..9340898.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA06895 BKN32417
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A9-50A9   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes	cbs is very tightly linked to cnn. (Megraw et al., 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\cbs for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cbs-RA FBtr0087666  NM_137031   2179   611 cbs-RB FBtr0309886     2155   603 cbs-RC FBtr0309887     2149   601
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cbs-PA   FBpp0086786   70.8   611   4.97     NP_610875   AAF58374 cbs-PB   FBpp0301620   69.9   603   4.93       cbs-PC   FBpp0301621   69.7   601   4.93
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GRIP (IPR000237)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58374   AI106635   AI294720   AI518834   AW943272   AY051853 AAK93277   BF503854   BI229539   BI355044   BI363683   BI365988   CO302826   CO320536   CZ484652   EC063021   EC250571   EV595555
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K4K7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086757    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086757 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086757 expression level Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1845) embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr  (257) embryo 08-10hr  (332) embryo 10-12hr  (483) embryo 12-14hr  (663) embryo 14-16hr  (552) embryo 16-18hr  (682) embryo 18-20hr  (543) embryo 20-22hr  (455) embryo 22-24hr  (530) larva L1  (553) larva L2  (573) larva L3 12hr old  (393) larva L3 puffstage 1-2  (692) larva L3 puffstage 3-6  (877) larva L3 puffstage 7-9  (1123) white prepupae new  (932) white prepupae 12hr  (1099) white prepupae 24hr  (1215) pupae 2d postWPP  (1264) pupae 3d postWPP  (872) pupae 4d postWPP  (513) adult male 01day  (863) adult male 05day  (1042) adult male 30day  (931) adult female 01day  (769) adult female 05day  (1634) adult female 30day  (1626) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1845) embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day  (1634) adult female 30day  (1626) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086757 expression level Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1845) embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr  (257) embryo 08-10hr  (332) embryo 10-12hr  (483) embryo 12-14hr  (663) embryo 14-16hr  (552) embryo 16-18hr  (682) embryo 18-20hr  (543) embryo 20-22hr  (455) embryo 22-24hr  (530) larva L1  (553) larva L2  (573) larva L3 12hr old  (393) larva L3 puffstage 1-2  (692) larva L3 puffstage 3-6  (877) larva L3 puffstage 7-9  (1123) white prepupae new  (932) white prepupae 12hr  (1099) white prepupae 24hr  (1215) pupae 2d postWPP  (1264) pupae 3d postWPP  (872) pupae 4d postWPP  (513) adult male 01day  (863) adult male 05day  (1042) adult male 30day  (931) adult female 01day  (769) adult female 05day  (1634) adult female 30day  (1626) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day  1634 adult female 30day  1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1845 embryo 02-04hr    74 embryo 04-06hr    70 embryo 06-08hr    257 embryo 08-10hr    332 embryo 10-12hr    483 embryo 12-14hr    663 embryo 14-16hr    552 embryo 16-18hr    682 embryo 18-20hr    543 embryo 20-22hr    455 embryo 22-24hr    530 larva L1    553 larva L2    573 larva L3 12hr old    393 larva L3 puffstage 1-2    692 larva L3 puffstage 3-6    877 larva L3 puffstage 7-9    1123 white prepupae new    932 white prepupae 12hr    1099 white prepupae 24hr    1215 pupae 2d postWPP    1264 pupae 3d postWPP    872 pupae 4d postWPP    513 adult male 01day    863 adult male 05day    1042 adult male 30day    931 adult female 01day    769 adult female 05day    1634 adult female 30day    1626 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086757    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086757 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval fat body, adult salivary gland, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086757 expression level Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland  (548.8) Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086757 expression level Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland  548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.925 Larval Midgut    35.7 Larval Hindgut    76.3 Larval Malpighian Tubules    110.5 Larval Fat Body    124 Larval Salivary Gland    548.8 Larval Trachea    71.9 Larval Carcass    68.575 Adult Head    72.2 Adult Eye    76.6 Adult Brain    252.3 Adult Thoracic-Abdominal Ganglion    258.2 Adult Crop    68.8 Adult Midgut    32.6 Adult Hindgut    72.5 Adult Malpighian Tubules    52.2 Adult Fat Body    63.8 Adult Salivary Gland    177.2 Adult Heart    49.225 Adult VirginFemale Spermatheca    70.1 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    335.3 Adult Testis    126.9 Adult Male Accessory Gland    106.5 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    72.2   NA  Eye    76.6   NA  Brain    252.3   162.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    258.2   NA  Crop    68.8   35.7  Midgut    32.6   76.3  Hindgut    72.5   110.5  Malpighian Tubules    52.2   124  Fat Body    63.8   548.8  Salivary Gland    177.2   NA  Heart    49.225   71.9  Trachea    NA   NA  VirginFemale Spermatheca    70.1   NA  InseminatedFemale Spermatheca    93.2   NA  Ovary    335.3   NA  Testis    126.9   NA  Male Accessory Gland    106.5   68.575  Carcass    57.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086757 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4840-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | partially, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsGRIP.Scer\UAS.P\T.T:Avic\GFP viable, with Scer\GAL4pnr-MD237 cbsGD11443 Phenotype manifest in Allele centrosome, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS centrosome | embryonic stage 4, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS centrosome | embryonic stage 5, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS centrosome | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsGRIP.Scer\UAS.P\T.T:Avic\GFP nucleus | embryonic stage 4, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS nucleus | embryonic stage 5, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS spindle | embryonic stage 4, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS stage 5 embryo, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS syncytial blastoderm embryo, with Scer\GAL4nos.UTR.T:Hsim\VP16 cbsdsRNA.Sym.Scer\UAS
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of cbs Class Mutagen Stocks Known lesion cbsG2391 P-element activity 1 -- cbsf02151 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cbs Class Mutagen Stocks Known lesion cbsGD11443 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cbsKK112417 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cbsdsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes cbsGRIP.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11443} NA P{KK112417} NA P{UAS-cbs-RNAi-UAS} NA P{UASp-cbs.GFP-GRIP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}cbsf02151 NA insertion of mobile activating element P{EP}cbsG2391 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome cycle inferred from mutant phenotype (Eisman et al., 2006)
Cellular Component
CV term Evidence References
chromatin inferred from direct assay (Eisman et al., 2006) cytoplasm inferred from direct assay (Eisman et al., 2006) perinuclear region of cytoplasm inferred from direct assay (Eisman et al., 2006) spindle inferred from direct assay (Eisman et al., 2006)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein targeting to Golgi inferred from electronic annotation with InterPro:IPR000237 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
centrosome non-traceable author statement (Megraw et al., 1999)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cbs allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62252 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086757 DroID - A comprehensive database of gene and protein interactions. • FBgn0086757 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36492
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA18469
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000569-PA Aedes aegypti (mosquito) AGAP001765-PA Anopheles gambiae (mosquito) XP_394136.3 Apis mellifera (honey bee) ENSBTAP00000020327 Bos taurus (bovine) ENSCAFP00000029974 Canis familiaris (dog) CPIJ007301 Culex pipens (mosquito) ENSCPOP00000013251 Cavia porcellus (guinea pig) ENSDARP00000089349 Danio rerio (zebra fish) ENSECAP00000012988 Equus caballus (horse) ENSGACP00000004689 Gymnopilus aculeatus (mushroom) ENSGALP00000001512 Gallus gallus (chicken) 178912 Hypsipyla robusta (cedar shoot borer) ENSP00000362656 Homo sapiens (human) ISCW017221-PA Ixodes scapularis (deer tick) ENSMODP00000024661 Monodelphis domestica (gray opossum) ENSMUSP00000037735 Mus musculus (house mouse) XP_001603845.1 Nasonia vitripennis (wasp) ENSOANP00000020999 Ornithorynchus anatinus (platypus) ENSORLP00000020690 Oryzias latipes (japanese killifish) ENSPPYP00000021969 Pongo pygmaeus (orangutan) ENSPTRP00000036510 Pan troglodytes (chimpanzee) ENSRNOP00000019703 Rattus norvegicus (norway rat) XP_971801.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005534 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017113 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11114 LH23907 ISCW017221 FBgn0230277 FBgn0212659 FBgn0208183 FBgn0182727 FBgn0176350 FBgn0078471 FBgn0154679 FBgn0143344 FBgn0130139 FBgn0112573 FBgn0090722 CPIJ007301 BGIBMGA005964 GB17464 AGAP001765 AAEL000569 PB22384 PHUM248480 GLEAN_14288
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	26992 y1 w*; P{EP}cbsG2391
VDRC	v103509 P{KK112417}VIE-260B v21959 w1118; P{GD11443}v21959
Genomic Clones ( 1 )
	BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35238
Other clones	DPiM_LD35238
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05071 GH06702 GM29321 LP08158 RE27343 RE48602 RE51402
Other clones	61730 180876 Dmel_neb_002038_0650_1744 EK184956 EK286021
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086757 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36492
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cbs CG4840 (Eisman et al., 2006)
Additional comments
Other Comments
	cbs protein undergoes a dramatic relocalization during mitosis from the cytoplasm to an association with chromosomes from late prometaphase to early telophase. (Eisman et al., 2006) cbs appears to participate in microtubule organising centre function. (Megraw et al., 1999) Transcription start sites of cnn and cbs are separated by a mere 134bp. Overall orientation not stated: cnn- cbs+ (Megraw, 1999.3.3)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137031 RefSeq (Proteins) • NP_610875 DDBJ / EMBL / GenBank • AAF58374 AAK93277 AI518834 AW943272 AY051853 CZ484652 Entrez Gene - A searchable database of RefSeq genes. • 36492 UniProtKB/TrEMBL • Q7K4K7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GRIP (IPR000237)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62252 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086757 DroID - A comprehensive database of gene and protein interactions. • FBgn0086757 DRSC - Results from RNAi screens. • FBgn0086757 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086757 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4840-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086757 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36492 InParanoid A subset of ortholog calls from InParanoid. • AAEL000569-PA Aedes aegypti (mosquito) AGAP001765-PA Anopheles gambiae (mosquito) XP_394136.3 Apis mellifera (honey bee) ENSBTAP00000020327 Bos taurus (bovine) ENSCAFP00000029974 Canis familiaris (dog) CPIJ007301 Culex pipens (mosquito) ENSCPOP00000013251 Cavia porcellus (guinea pig) ENSDARP00000089349 Danio rerio (zebra fish) ENSECAP00000012988 Equus caballus (horse) ENSGACP00000004689 Gymnopilus aculeatus (mushroom) ENSGALP00000001512 Gallus gallus (chicken) 178912 Hypsipyla robusta (cedar shoot borer) ENSP00000362656 Homo sapiens (human) ISCW017221-PA Ixodes scapularis (deer tick) ENSMODP00000024661 Monodelphis domestica (gray opossum) ENSMUSP00000037735 Mus musculus (house mouse) XP_001603845.1 Nasonia vitripennis (wasp) ENSOANP00000020999 Ornithorynchus anatinus (platypus) ENSORLP00000020690 Oryzias latipes (japanese killifish) ENSPPYP00000021969 Pongo pygmaeus (orangutan) ENSPTRP00000036510 Pan troglodytes (chimpanzee) ENSRNOP00000019703 Rattus norvegicus (norway rat) XP_971801.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005534 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017113 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/centrosombsis1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36492 modMine - Data generated by the modENCODE project. • FBgn0086757 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11114 LH23907 ISCW017221 FBgn0230277 FBgn0212659 FBgn0208183 FBgn0182727 FBgn0176350 FBgn0078471 FBgn0154679 FBgn0143344 FBgn0130139 FBgn0112573 FBgn0090722 CPIJ007301 BGIBMGA005964 GB17464 AGAP001765 AAEL000569 PB22384 PHUM248480 GLEAN_14288
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	cbs (Eisman et al., 2006, ) Cbs (Finan et al., 2011) CG4840 (Eisman et al., 2006, Yepiskoposyan et al., 2006, Sinka et al., 2008, Keleman et al., 2009.8.5) dem (Megraw et al., 1998, Megraw et al., 1999)
Name Synonym	centrosomin's beautiful sister (Megraw, 1999.3.3, Eisman et al., 2006) Centrosomin's beautiful sister (Finan et al., 2011) CG4840   dementin (Megraw et al., 1999) dGolgin-97 (Sinka et al., 2008)
Secondary FlyBase IDs
	FBgn0026256 FBgn0033840
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Show all research papers ...