Dα7, gfA, nAcRα-18C, nAChR, giant fibre A
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nAChRα7 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nAChRα7 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG8082 and CG8109 merged as CG32538 in release 3 of the genome annotation.
Source for identity of nAcRα-18C CG8109 was sequence comparison ( date:020502 ).
gfA complements pas.
Mutations disrupt the synaptic transmission of the giant fibre (GF) - dorso-longitudinal muscle (DLM) pathway.
Adults have an aberrant startle response; they do not jump when presented with a lights-off stimulus. The dorso-longitudinal indirect flight muscles (DLMs) are abnormally driven by the giant fiber pathway neurons (see entry for ben). DLMs are driven at long and variable latencies after brain stimulation. Morphology of the giant fiber and its response to stimulation is normal. The motor neuron of the tergotrochanteral (jump) muscle is driven normally by the giant fiber. The physiological defect in gfA is probably located at the synapses between the peripherally synapsing interneuron (PSI) and the DLM motor neurons in the thoracic ganglion.