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Gene Dmel\stmA

General Information
Symbol	Dmel\stmA	Species	D. melanogaster
Name	stambha A	Annotation symbol	CG8739
Feature type	protein_coding_gene	FlyBase ID	FBgn0086784
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	cmp44E, rbo
Genomic Location
Chromosome (arm)	2R	Recombination map	2-56.8
Cytogenetic map	44E3-44E3	Sequence location	2R:4,617,003..4,621,809 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene stambha A is referred to in FlyBase by the symbol Dmel\stmA (CG8739, FBgn0086784). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: synaptic transmission; phototransduction; regulation of endocytosis; synaptic vesicle endocytosis; cytokinesis; synaptic vesicle exocytosis. 49 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; multicellular structure; synapse; portion of tissue; extended germ band embryo; embryonic hindgut; cytoplasmic part; sensory cluster; external compound sense organ; late extended germ band embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641233_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of stmA. Gene sequence location is 2R:4617003..4621809.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	stm-A Two-hour heat shocks applied throughout development show 0-8 h and 56-140 h to be highly sensitive, with no survival; 8-56 h and after 140 h show survival with normal phenotype. Early temperature shock leads to blastoderm arrest with no gastrulation. Embryos produced by homozygous stm-A mothers are exceedingly sensitive to a two-hour exposure to 36; leads to complete lethality from 0-3 h irrespective of paternal contribution.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA07593 BKN20589 HFA05120 BKN45292
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44E3-44E3   Limits computationally determined from genome sequence between P{PZ}l(2)44DEa05847 and P{lacW}Rya-r44Fk04913
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44D1-44D2   FBrf0065355 concluded that stmA mapped to 42A16-42B2, however deficiency mapping in FBrf0144960 suggests that stmA maps to 44D1-44D2.   (Kumar et al., 2001) 44E3-44E4     (Faulkner, 1998.10.15)
Experimentally Determined Recombination Data
Location	2-56.8 (Chandrashekaran and Sarla, 1993, Chandrashekaran, 1993)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\stmA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) stmA-RA FBtr0088716  NM_165625   2782   794 stmA-RB FBtr0088715  NM_165624   3105   820 stmA-RC FBtr0301639  NM_001014513   3162   834
Additional Transcript Data & Comments
Reported size (kB)	3.4, 2.9 (northern blot) (Faulkner et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein stmA-PA   FBpp0087795   89.3   794   6.85     NP_724711   AAF59046 stmA-PB   FBpp0087794   92.4   820   6.62     NP_724710   AAF59047 stmA-PC   FBpp0100147   94.0   834   6.76     NP_001014513   AAX52723
Additional Polypeptide Data & Comments
Reported size (kDa)	794 (aa); 91 (kD predicted) (Faulkner et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202906   AA698629   AA801554   AE013599 AAF59046   AE013599 AAF59047   AE013599 AAX52723   AF099028 AAD12254   AI062413   AI109393   AI110069   AI110168   AI113387   AI113623   AI135611   AI135924   AI257064   AI260318   AI293576   AI402533   AI403816   AW942044   AY061062 AAL28610   BE976802   BF487590   BG632497   BG635992   BG637695   BH614996   BI212337   BI361353   BI371099   BI566573   BI571153   BI571570   BI571820   BI571883   BI572100   BI572523   BI573079   BI586993   BI591624   BI604450   BI605479   BI605765   BI610951   BI612782   BI612935   BI616857   BI619320   BI628004   BI628624   BI629588   BI631786   BI631868   BP557313   BP557314   BT001762 AAN71517   BT032775   CA807322   CK132543   CK605386   CK605387   CK661497   CL705838   CO179618   CO262785   CO263809   CO265892   CO269225   CO290924   CO291120   CO293844   CO320574   CO323917   CO328735   CO328841   CO329892   CO340474   CO341666   CZ477967   CZ486490   EC082593   EC200774   EC204882   EC205102   EC209938   EC212656   EC218814   EC227663   EC230899   EC231108   EC232833   EC257046   EC259397   ES690070   GH942144   GH944322   GH946324   GH947702   GH947891   GH947988   GH948523   GH948884   GH950186   GH950650   GH954684   GH954909   GH955667   GH955705   GH957068   GH957428   GH957752   GH958787   GH958854   GH960815   GH961120   GH961350   GH963095   GH965281   GH970403   GH974067   GH974223   GH975632   GH976236   GH976737   GH977248   GH979966   GH981899
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGJ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Faulkner et al., 1998) embryonic brain   (Faulkner et al., 1998) presumptive embryonic/larval central nervous system   (Faulkner et al., 1998) adult stage & oogenesis   germarium   (Faulkner et al., 1998) follicle cell   (Faulkner et al., 1998) adult stageoogenesis stage S1 -- S5   nurse cell   (Faulkner et al., 1998) adult stageoogenesis stage S9 -- S14     (Faulkner et al., 1998) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & adult stage     (Faulkner et al., 1998) embryonic stage -- adult stage     (Faulkner et al., 1998)
Additional Descriptive Data
	The 2.9kb stmA transcript is detected throughout development and in adults on northern blots. (Faulkner et al., 1998) stmA transcripts are ubiquitously distributed in the first half of embryogenesis. They later become more concentrated in the CNS and brain. stmA transcripts are detected in the germline throughout the germarial stages. They are expressed in nurse cells until stage 5 and then are not detected again until stage 9, at which time they are present at high levels. Lower levels are also observed in follicle cells. (Faulkner et al., 1998) The 3.4kb stmA transcript is detected in 12-23hr embryos and in adults. It is present at lower abundance than the 2.9kb transcript. (Faulkner et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086784    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086784 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086784 expression level Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2813) embryo 02-04hr  (1232) embryo 04-06hr  (936) embryo 06-08hr  (1059) embryo 08-10hr  (1150) embryo 10-12hr  (1178) embryo 12-14hr  (1030) embryo 14-16hr  (1336) embryo 16-18hr  (1632) embryo 18-20hr  (1889) embryo 20-22hr  (1604) embryo 22-24hr  (1731) larva L1  (1652) larva L2  (1195) larva L3 12hr old  (1096) larva L3 puffstage 1-2  (976) larva L3 puffstage 3-6  (1088) larva L3 puffstage 7-9  (1106) white prepupae new  (1085) white prepupae 12hr  (1394) white prepupae 24hr  (1221) pupae 2d postWPP  (1497) pupae 3d postWPP  (2413) pupae 4d postWPP  (3162) adult male 01day  (3039) adult male 05day  (3068) adult male 30day  (2795) adult female 01day  (2374) adult female 05day  (2169) adult female 30day  (2210) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2813) embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr  (1632) embryo 18-20hr  (1889) embryo 20-22hr  (1604) embryo 22-24hr  (1731) larva L1  (1652) larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP  1497 pupae 3d postWPP  (2413) pupae 4d postWPP  (3162) adult male 01day  (3039) adult male 05day  (3068) adult male 30day  (2795) adult female 01day  (2374) adult female 05day  (2169) adult female 30day  (2210) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086784 expression level Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2813) embryo 02-04hr  (1232) embryo 04-06hr  (936) embryo 06-08hr  (1059) embryo 08-10hr  (1150) embryo 10-12hr  (1178) embryo 12-14hr  (1030) embryo 14-16hr  (1336) embryo 16-18hr  (1632) embryo 18-20hr  (1889) embryo 20-22hr  (1604) embryo 22-24hr  (1731) larva L1  (1652) larva L2  (1195) larva L3 12hr old  (1096) larva L3 puffstage 1-2  (976) larva L3 puffstage 3-6  (1088) larva L3 puffstage 7-9  (1106) white prepupae new  (1085) white prepupae 12hr  (1394) white prepupae 24hr  (1221) pupae 2d postWPP  (1497) pupae 3d postWPP  (2413) pupae 4d postWPP  (3162) adult male 01day  (3039) adult male 05day  (3068) adult male 30day  (2795) adult female 01day  (2374) adult female 05day  (2169) adult female 30day  (2210) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2813) embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr  1632 embryo 18-20hr  1889 embryo 20-22hr  1604 embryo 22-24hr  1731 larva L1  1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP  1497 pupae 3d postWPP  2413 pupae 4d postWPP  (3162) adult male 01day  (3039) adult male 05day  (3068) adult male 30day  (2795) adult female 01day  2374 adult female 05day  2169 adult female 30day  2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2813 embryo 02-04hr    1232 embryo 04-06hr    936 embryo 06-08hr    1059 embryo 08-10hr    1150 embryo 10-12hr    1178 embryo 12-14hr    1030 embryo 14-16hr    1336 embryo 16-18hr    1632 embryo 18-20hr    1889 embryo 20-22hr    1604 embryo 22-24hr    1731 larva L1    1652 larva L2    1195 larva L3 12hr old    1096 larva L3 puffstage 1-2    976 larva L3 puffstage 3-6    1088 larva L3 puffstage 7-9    1106 white prepupae new    1085 white prepupae 12hr    1394 white prepupae 24hr    1221 pupae 2d postWPP    1497 pupae 3d postWPP    2413 pupae 4d postWPP    3162 adult male 01day    3039 adult male 05day    3068 adult male 30day    2795 adult female 01day    2374 adult female 05day    2169 adult female 30day    2210 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086784    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086784 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086784 expression level Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain    1273.1 Adult Thoracic-Abdominal Ganglion    1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain  (1273.1) Adult Thoracic-Abdominal Ganglion  (1072.4) Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain  (1273.1) Adult Thoracic-Abdominal Ganglion  1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain    1273.1 Adult Thoracic-Abdominal Ganglion    1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086784 expression level Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain    1273.1 Adult Thoracic-Abdominal Ganglion    1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain  (1273.1) Adult Thoracic-Abdominal Ganglion  (1072.4) Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain  1273.1 Adult Thoracic-Abdominal Ganglion  1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.025 Larval Midgut    100.2 Larval Hindgut    164.7 Larval Malpighian Tubules    60.2 Larval Fat Body    75.5 Larval Salivary Gland    114.5 Larval Trachea    90.075 Larval Carcass    92.3 Adult Head    333.5 Adult Eye    305.725 Adult Brain    1273.1 Adult Thoracic-Abdominal Ganglion    1072.4 Adult Crop    193.8 Adult Midgut    141.2 Adult Hindgut    357.1 Adult Malpighian Tubules    147.9 Adult Fat Body    135.9 Adult Salivary Gland    170.2 Adult Heart    98.45 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    82.7 Adult Ovary    146.6 Adult Testis    113.9 Adult Male Accessory Gland    137.7 Adult Carcass    152.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    333.5   NA  Eye    305.725   NA  Brain    1273.1   150.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1072.4   NA  Crop    193.8   100.2  Midgut    141.2   164.7  Hindgut    357.1   60.2  Malpighian Tubules    147.9   75.5  Fat Body    135.9   114.5  Salivary Gland    170.2   NA  Heart    98.45   90.075  Trachea    NA   NA  VirginFemale Spermatheca    78.9   NA  InseminatedFemale Spermatheca    82.7   NA  Ovary    146.6   NA  Testis    113.9   NA  Male Accessory Gland    137.7   92.3  Carcass    152.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086784
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with stmA1-2) stmA12 lethal (with stmA1-4) stmA12 lethal (with stmA2-2) stmA12 lethal (with stmA12) stmA1-2 stmA1-4 stmA2-2 stmA18-2 stmA27-1 stmAPEL1 stmAPEL3 stmAPEL4 stmAPEL6 stmAPEL8 stmAPEL11 lethal (with stmA18-2) stmA12 lethal (with stmA27-1) stmA12 lethal (with stmAPEL1) stmA12 lethal (with stmAPEL3) stmA12 lethal (with stmAPEL4) stmA12 lethal (with stmAPEL6) stmA12 lethal (with stmAPEL8) stmA12 lethal (with stmAPEL11) stmA12 lethal | embryonic stage stmAcmp44E-1 stmAcmp44E-3 stmAcmp44E-4 stmAcmp44E-5 lethal | embryonic stage | recessive stmA7 stmA12 stmArev499 stmArev522 lethal | heat sensitive stmA1 stmA2 lethal | maternal effect stmA7 stmA12 lethal | pupal stage, with Scer\GAL4pnr-MD237 stmAGD14013 lethal | recessive stmA7 stmA12 stmAKP1 stmAKP2 stmAKP3 stmAKP4 stmAKP5 stmAKP6 stmAp1 stmAp2 stmAp3 stmAp4 stmAp5 stmArev787 stmArev792 stmArev828 lethal | semidominant stmAPEL1 stmAPEL3 stmAPEL4 stmAPEL6 stmAPEL8 stmAPEL11 viable stmA1 stmA2 stmAp1 stmAp2 stmAp4 stmApngcl Other Phenotypes Allele chemical resistant stmA1 stmA2 stmAp1 stmAp2 stmAp4 flight defective stmA1 stmAp1 stmAp4 gravitaxis behavior defective stmA1 stmA2 stmAp1 stmAp4 hyperactive stmA2 hypoactive stmA1 stmAp1 neurophysiology defective | heat sensitive stmA1 neurophysiology defective | heat sensitive (with stmA1) stmArev499 neurophysiology defective | heat sensitive (with stmArev499) stmA1 paralytic | adult stage | semidominant stmA1 stmA2 paralytic | dominant stmA7 stmA12 paralytic | dominant | heat sensitive stmA7 stmA12 paralytic | heat sensitive stmA1 stmA2 stmA18-2 stmAp1 stmAp2 stmAp4 stmArev499 paralytic | heat sensitive (with Df(2R)H3C1) stmA1 stmAp1 paralytic | heat sensitive (with Df(2R)H3D3) stmA1 paralytic | heat sensitive (with Df(2R)H3E1) stmA1 stmAp1 paralytic | heat sensitive (with stmA1) stmA2 stmA7 stmA12 stmA18-2 stmAKP1 stmAKP2 stmAKP3 stmAKP4 stmAKP5 stmAKP6 stmAp1 stmAp2 stmAp3 stmAp4 stmAp5 stmAPEL1 stmAPEL3 stmAPEL4 stmAPEL6 stmAPEL8 stmAPEL11 stmArev499 paralytic | heat sensitive (with stmA2) stmA1 paralytic | heat sensitive (with stmA7) stmA1 paralytic | heat sensitive (with stmA12) stmA1 paralytic | heat sensitive (with stmA18-2) stmA1 paralytic | heat sensitive (with stmAKP1) stmA1 paralytic | heat sensitive (with stmAKP2) stmA1 paralytic | heat sensitive (with stmAKP3) stmA1 paralytic | heat sensitive (with stmAKP4) stmA1 paralytic | heat sensitive (with stmAKP5) stmA1 paralytic | heat sensitive (with stmAKP6) stmA1 paralytic | heat sensitive (with stmAp1) stmA1 paralytic | heat sensitive (with stmAp2) stmA1 paralytic | heat sensitive (with stmAp3) stmA1 paralytic | heat sensitive (with stmAp4) stmA1 paralytic | heat sensitive (with stmAp5) stmA1 paralytic | heat sensitive (with stmAPEL1) stmA1 paralytic | heat sensitive (with stmAPEL3) stmA1 paralytic | heat sensitive (with stmAPEL4) stmA1 paralytic | heat sensitive (with stmAPEL6) stmA1 paralytic | heat sensitive (with stmAPEL8) stmA1 paralytic | heat sensitive (with stmAPEL11) stmA1 paralytic | heat sensitive (with stmArev499) stmA1 paralytic | larval stage | semidominant stmA1 stmA2 paralytic | recessive | heat sensitive stmA1 visible | recessive stmArev499 stmArev522 wild-type stmA+t8.5 stmA+t17 stmApngcl Phenotype manifest in Allele amnioserosa stmA12 stmA7 antenno-maxillary complex stmA1 cephalopharyngeal skeleton | embryonic stage stmA12 stmA7 cuticle | anterior | dorsal stmA12 stmA7 denticle belt | embryonic stage stmA12 stmA7 dorsal medial muscle stmA1 ectoderm stmA12 stmA7 embryonic/larval brain | embryonic stage stmA12 stmA7 embryonic/larval foregut | embryonic stage stmA12 stmA7 embryonic/larval neuromuscular junction stmA1 stmArev499 embryonic/larval neuromuscular junction (with stmA1) stmArev499 embryonic/larval neuromuscular junction (with stmArev499) stmA1 embryonic/larval pharynx | embryonic stage stmA12 stmA7 embryonic epidermis stmA1 stmA2 extended germ band embryo stmA12 stmA7 eye stmArev499 stmArev522 garland cell | wandering third instar larval stage | temperature conditional stmA1 head stmA12 stmA7 labral segment stmA12 stmA7 leg stmArev499 stmArev522 mesothoracic extracoxal depressor muscle 66 stmA1 NMJ bouton | wandering third instar larval stage | temperature conditional stmA1 presynaptic active zone membrane stmA1 proctodeum stmA12 stmA7 retina | heat sensitive (with stmA1) stmArev499 retina | heat sensitive (with stmArev499) stmA1 subesophageal ganglion stmA1 synaptic vesicle stmA1 terminal button stmA1 ventral nerve cord stmA1 stmA12 stmA7
Classical Alleles ( 43 )
For All Classical Alleles Show
Allele of stmA Class Mutagen Stocks Known lesion stmAcmp44E-1 ethyl methanesulfonate 2 -- stmAKG03925 P-element activity 2 -- stmA18-2 gamma ray 1 Yes stmA1 neomorphic allele - genetic evidence 1 Yes stmA2 neomorphic allele - genetic evidence ethyl methanesulfonate 1 -- stmAe00058 piggyBac transposase 1 -- stmAEY09152 P-element activity 1 -- stmAf03887 piggyBac transposase 1 -- stmANP0882 1 -- stmA1-2 gamma ray 0 -- stmA1-4 gamma ray 0 -- stmA12 ethyl methanesulfonate 0 -- stmA2-2 gamma ray 0 -- stmA27-1 gamma ray 0 -- stmA7 ethyl methanesulfonate 0 -- stmAcmp44E-3 ethyl methanesulfonate 0 -- stmAcmp44E-4 ethyl methanesulfonate 0 -- stmAcmp44E-5 ethyl methanesulfonate 0 -- stmAKP1 ethyl methanesulfonate 0 -- stmAKP2 ethyl methanesulfonate 0 -- stmAKP3 ethyl methanesulfonate 0 -- stmAKP4 ethyl methanesulfonate 0 -- stmAKP5 ethyl methanesulfonate 0 -- stmAKP6 ethyl methanesulfonate 0 -- stmAp1 Delta2-3 0 -- stmAp2 Delta2-3 0 -- stmAp3 Delta2-3 0 -- stmAp4 Delta2-3 0 Yes stmAp5 Delta2-3 0 -- stmAPEL11 Delta2-3 0 Yes stmAPEL1 Delta2-3 0 Yes stmAPEL3 Delta2-3 0 Yes stmAPEL4 Delta2-3 0 Yes stmAPEL6 Delta2-3 0 Yes stmAPEL8 Delta2-3 0 Yes stmApngcl P-element activity 0 Yes stmArbo-P1 P-element activity 0 Yes stmArbo-P2 P-element activity 0 Yes stmArev499 loss of function allele Delta2-3 0 Yes stmArev522 Delta2-3 0 Yes stmArev787 Delta2-3 0 Yes stmArev792 Delta2-3 0 Yes stmArev828 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of stmA Class Mutagen Stocks Known lesion stmAGD14013 in vitro construct - RNAi in vitro construct - regulatory fusion 4 Yes stmAKK100493 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes stmA+t17 in vitro construct - genomic fragment 0 Yes stmA+t8.5 in vitro construct - genomic fragment 0 Yes stmAMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes stmAT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC268 (Christensen et al., 2008.12.28) Df(2R)BSC269 (Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22) Df(2R)cmp44E-rev390 (Faulkner et al., 1998, Robertson et al., 1999) Df(2R)H3C1 (Kumar et al., 2001, Huang et al., 2004) Df(2R)H3D3 (Huang et al., 2004, Huang et al., 2006) Df(2R)H3E1 (Rao et al., 2001, Kumar et al., 2001, Dockendorff et al., 2000) Df(2R)Np3 (Huang et al., 2004)
Partially disrupted in	Df(2R)H3C1 (Rao et al., 2001)
Not disrupted in	Df(2R)42 (Chandrashekaran and Sarla, 1993) Df(2R)44CE (Kumar et al., 2001) Df(2R)cn9 (Kumar et al., 2001) Df(2R)cn87e (Kumar et al., 2001) Df(2R)pk78k (Chandrashekaran and Sarla, 1993) Df(2R)pk78s (Chandrashekaran and Sarla, 1993) Df(2R)rl10a (Chandrashekaran and Sarla, 1993) Df(2R)rl10b (Chandrashekaran and Sarla, 1993) Df(2R)ST1 (Chandrashekaran and Sarla, 1993) Df(2R)V30 (Chandrashekaran and Sarla, 1993) In(2R)D5LTE146-sz4R (Chandrashekaran and Sarla, 1993)
Duplicated in	Dp(2;3)P32 (Chandrashekaran and Sarla, 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14013} NA P{KK100493} NA characterization construct P{stmA-EGFP.H} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP2233 NA P{EPgy2}stmAEY09152 NA P{GSV1}EP-405EP-405 NA insertion of enhancer trap P{lacW}l(2)SH0382SH0382 No P{lacW}stmApngcl No P{lacW}stmArbo-P1 No P{lacW}stmArbo-P2 No insertion of enhancer trap binary system P{GawB}stmANP0882 No miscellaneous insertions P{}stmAp1 NA P{}stmAp4 NA P{SUPor-P}stmAKG03925 NA PBac{RB}stmAe00058 NA PBac{WH}stmAf03887 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Echard et al., 2004) phototransduction inferred from mutant phenotype (Huang et al., 2004) regulation of endocytosis inferred from mutant phenotype (Vijayakrishnan et al., 2009) synaptic transmission inferred from mutant phenotype (Huang et al., 2006) synaptic vesicle endocytosis inferred from mutant phenotype (Vijayakrishnan et al., 2009) synaptic vesicle exocytosis inferred from mutant phenotype (Huang et al., 2006)
Cellular Component
CV term Evidence References
integral to membrane of membrane fraction inferred from direct assay (Huang et al., 2004) synapse inferred from direct assay (Vijayakrishnan et al., 2009)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011989, InterPro:IPR016024 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Faulkner, 1998.10.15)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions stmA allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61713 DroID - A comprehensive database of gene and protein interactions. • FBgn0086784 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35865
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA21293
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007884-PA Aedes aegypti (mosquito) AGAP012183-PA Anopheles gambiae (mosquito) XP_001120727.1 Apis mellifera (honey bee) XP_001947633.1 Acyrthosiphon pisum (pea aphid) At5g26850.1 Arabidopsis thaliana (wall cress) 27181 Batrachochytrium dendrobatidis (chytrid fungus) 110989 Branchiostoma floridae (lancelet) 111695 Branchiostoma floridae (lancelet) XP_001902723.1 Brugia malayi (roundworm nematode) BGIBMGA013649-PA Bombyx mori (silk worm) ENSBTAP00000032868 Bos taurus (bovine) CBP35211 Caenorhabditis briggsae (nematode) CE01843 Caenorhabditis elegans (worm) ENSCAFP00000006147 Canis familiaris (dog) ENSCINP00000010129 Ciona intestinalis (sea squirt) JA17276 Caenorhabditis japonica (nematode) CPIJ017966 Culex pipens (mosquito) ENSCPOP00000011916 Cavia porcellus (guinea pig) RP34719 Caenorhabditis remanei (nematode) ENSCSAVP00000003152 Ciona savignyi (sedentary tunicate) 225122 Capitella spl (polychaete worm) DDB0219543 Dictyostelium discoideum (amoeba) 315767 Daphnia pulex (daphnia) ENSDARP00000091534 Danio rerio (zebra fish) ENSECAP00000014802 Equus caballus (horse) ENSGACP00000013328 Gymnopilus aculeatus (mushroom) ENSGALP00000026747 Gallus gallus (chicken) 190477 Hypsipyla robusta (cedar shoot borer) ENSP00000386082 Homo sapiens (human) ISCW003004-PA Ixodes scapularis (deer tick) 166379 Lottia gigantea (owl limpet) ENSMODP00000019783 Monodelphis domestica (gray opossum) ENSMMUP00000021630 Macaca mulatta (rhesus monkey) ENSMUSP00000106809 Mus musculus (house mouse) 241346 Nematostella vectensis (starlet anemone) XP_001599882.1 Nasonia vitripennis (wasp) ENSOANP00000012880 Ornithorynchus anatinus (platypus) ENSORLP00000016977 Oryzias latipes (japanese killifish) LOC_Os03g19520.2 Oryza sativa (asian rice) PHUM004315-PA Pediculus humanus (human body louse) PP06792 Pristionchus pacificus (nematode) 132325 Physcomitrella patens (moss) ENSPPYP00000021190 Pongo pygmaeus (orangutan) 729421 Populus trichocarpa (black cottonwood) ENSPTRP00000020132 Pan troglodytes (chimpanzee) ENSRNOP00000034836 Rattus norvegicus (norway rat) 5049562 Sorghum bicolor (sorghum) Smp_158300 Schistosoma mansoni (trematode parasite) 27697 Trichoplax adhaerens (metazoa) XP_969642.2 Tribolium castaneum (red flour beetle) ENSTNIP00000019479 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036342 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000049792 Xenopus tropicalis (frog) YALI0D20042g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14177 NV16792 LH13847 ISCW003004 FBgn0239984 FBgn0222935 FBgn0206804 FBgn0186935 FBgn0181913 FBgn0175546 JGI_V11_315767 FBgn0081281 FBgn0154962 FBgn0143357 FBgn0130152 FBgn0102926 FBgn0089603 CPIJ017966 BGIBMGA013649 ACYPI009050 GB16981 AGAP012183 AAEL007884 GLEAN_09038
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	34517 stmA1 34518 stmA2 34519 stmA18-2/CyO 5494 stmAcmp44E-1/CyO
Harvard	- PBac{RB}stmAe00058 - PBac{WH}stmAf03887
Kyoto	108259 stmAcmp44E-1/CyO
VDRC	v105391 P{KK100493}VIE-260B v23618 w1118 P{GD14013}v23618 v23619 w1118 P{GD14013}v23619 v47750 w1118; P{GD14013}v47750 v47751 w1118; P{GD14013}v47751
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Genomic Clones ( 1 )
	BACR43I04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 112 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD03322 RH07443
Other clones	IP20990
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT22557 GH01607 GH08569 GH09003 GH09523 GH10005 GH13431 GH13847 GH21770 GH23333 HL05359 LP04106 LP05322 LP06746 LP14136 LP21060 RE17414 RE45530 RE57922 RH05976 RH06374 RH06821 RH07120 RH07189 RH08060 RH08775 RH16987 RH27240 RH36256 RH41748 RH41943 RH46961 RH50333 RH57124 RH58478 RH61434 RH61534 RH69528 RH69802 RH71095 SD13546
Other clones	16465 28677 65234 74747 181662 191403 214407.39 214537.46 272525 bs56a10 CK01.76D.G3 CK01.97C.F6 CK01.102C.D8 CK01.123C.F9 EK060026 EK075555 EK076208 EK086348 EK093923 EK136521 EK144402 EK191945 EK204953 EK286321 EK291264 EK291515 EK294118 EP10722 EP12921 ESG017b.E21_H02 FGM308F03 GH09667 HL06650 RH71695 RP004021168 RP004022935 RP004051629 RP004058250 RP004066196 RP004091906 RP004092677 RP004107243 RP004110013 RP004170913 RP004175959 RP004192507 RP004195853 RP004203250 RP004204431 RP004205592 RP004221160 RP004226813 RP004242264 RP004246115 RP004258958 RP004297712 RP004313060 RP004324474 RP004338425 RP004367913 RP004370376 RP004427831 RP004493979 RP004517999 RP004536222 RP004538382 RP004542751 UT01891
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086784 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35865 47864
Antibody Information
Other Information
Discoverer
Etymology
	'stambh' is a Sanskrit word meaning "cessation in general and of locomotion in particular". (Chandrashekaran, 2005.1.4)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: stmA cmp44E rbo (Huang et al., 2004)
Additional comments
Other Comments
	stmA is required for both peripheral glutamatergic neuromuscular junction and central cholinergic PSI-DLMn synaptic transmission. (Huang et al., 2006) stmA is required at the postdocking stage of synaptic vesicle exocytosis, during vesicle priming, or fusion stages. (Huang et al., 2006) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) Required for embryonic development and, in conditional mutants, the acute maintenance of coordinated mobility and phototransduction. (Huang et al., 2001) Homozygous or heterozygous conditional mutant alleles display slow, temperature sensitive adult paralysis and complete, reversible loss of phototransduction in electroretinogram (ERG) records in the adult eye. Mutants show altered synaptic morphology at the larval neuromuscular junction. (Huang et al., 2001) Mutation of stmA causing paralysis also confers veratridine resistance, the two effects are genetically inseparable. (Chandrashekaran, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165624 NM_165625 NM_001014513 RefSeq (Proteins) • NP_724710 NP_724711 NP_001014513 DDBJ / EMBL / GenBank • AA202906 AAD12254 AAF59046 AAF59046.2 AAF59047 AAF59047.2 AAL28610 AAN71517 AAX52723 AF099028 AW942044 AY061062 BH614996 BI572100 BT001762 CL705838 CZ477967 CZ486490 Entrez Gene - A searchable database of RefSeq genes. • 35865 UniProtKB/TrEMBL • Q8IGJ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61713 DroID - A comprehensive database of gene and protein interactions. • FBgn0086784 DRSC - Results from RNAi screens. • FBgn0086784 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086784 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086784 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35865 47864 InParanoid A subset of ortholog calls from InParanoid. • AAEL007884-PA Aedes aegypti (mosquito) AGAP012183-PA Anopheles gambiae (mosquito) XP_001120727.1 Apis mellifera (honey bee) XP_001947633.1 Acyrthosiphon pisum (pea aphid) At5g26850.1 Arabidopsis thaliana (wall cress) 27181 Batrachochytrium dendrobatidis (chytrid fungus) 110989 Branchiostoma floridae (lancelet) 111695 Branchiostoma floridae (lancelet) XP_001902723.1 Brugia malayi (roundworm nematode) BGIBMGA013649-PA Bombyx mori (silk worm) ENSBTAP00000032868 Bos taurus (bovine) CBP35211 Caenorhabditis briggsae (nematode) CE01843 Caenorhabditis elegans (worm) ENSCAFP00000006147 Canis familiaris (dog) ENSCINP00000010129 Ciona intestinalis (sea squirt) JA17276 Caenorhabditis japonica (nematode) CPIJ017966 Culex pipens (mosquito) ENSCPOP00000011916 Cavia porcellus (guinea pig) RP34719 Caenorhabditis remanei (nematode) ENSCSAVP00000003152 Ciona savignyi (sedentary tunicate) 225122 Capitella spl (polychaete worm) DDB0219543 Dictyostelium discoideum (amoeba) 315767 Daphnia pulex (daphnia) ENSDARP00000091534 Danio rerio (zebra fish) ENSECAP00000014802 Equus caballus (horse) ENSGACP00000013328 Gymnopilus aculeatus (mushroom) ENSGALP00000026747 Gallus gallus (chicken) 190477 Hypsipyla robusta (cedar shoot borer) ENSP00000386082 Homo sapiens (human) ISCW003004-PA Ixodes scapularis (deer tick) 166379 Lottia gigantea (owl limpet) ENSMODP00000019783 Monodelphis domestica (gray opossum) ENSMMUP00000021630 Macaca mulatta (rhesus monkey) ENSMUSP00000106809 Mus musculus (house mouse) 241346 Nematostella vectensis (starlet anemone) XP_001599882.1 Nasonia vitripennis (wasp) ENSOANP00000012880 Ornithorynchus anatinus (platypus) ENSORLP00000016977 Oryzias latipes (japanese killifish) LOC_Os03g19520.2 Oryza sativa (asian rice) PHUM004315-PA Pediculus humanus (human body louse) PP06792 Pristionchus pacificus (nematode) 132325 Physcomitrella patens (moss) ENSPPYP00000021190 Pongo pygmaeus (orangutan) 729421 Populus trichocarpa (black cottonwood) ENSPTRP00000020132 Pan troglodytes (chimpanzee) ENSRNOP00000034836 Rattus norvegicus (norway rat) 5049562 Sorghum bicolor (sorghum) Smp_158300 Schistosoma mansoni (trematode parasite) 27697 Trichoplax adhaerens (metazoa) XP_969642.2 Tribolium castaneum (red flour beetle) ENSTNIP00000019479 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036342 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000049792 Xenopus tropicalis (frog) YALI0D20042g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35865 modMine - Data generated by the modENCODE project. • FBgn0086784 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14177 NV16792 LH13847 ISCW003004 FBgn0239984 FBgn0222935 FBgn0206804 FBgn0186935 FBgn0181913 FBgn0175546 JGI_V11_315767 FBgn0081281 FBgn0154962 FBgn0143357 FBgn0130152 FBgn0102926 FBgn0089603 CPIJ017966 BGIBMGA013649 ACYPI009050 GB16981 AGAP012183 AAEL007884 GLEAN_09038
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG8739 (Molnar et al., 2006, Keleman et al., 2009.8.5) cmp44E (Huang et al., 2004, Christensen and Cook, 2007.3.22, Kadener et al., 2006, Molnar et al., 2006, Christensen et al., 2008.12.28, Liebl and Featherstone, 2005) rbo (Huang et al., 2004, Huang et al., 2006, Vijayakrishnan et al., 2009, Kain et al., 2009) stambhA (Kain et al., 2009) stmA (Huang et al., 2004, Jain and Chandrashekara, 2003, Kumar et al., 2001, Kain et al., 2009, Wasbrough et al., 2010) stm-A (Jain and Sharma, 1991, )
Name Synonym	conserved membrane protein at 44E (Faulkner et al., 1998) Rolling blackout (Chandrashekaran, 2005.1.4, Huang et al., 2006, Vijayakrishnan et al., 2009) rolling blackout (Huang et al., 2001, Kain et al., 2009) stambh A (Chandrashekaran, 1993) stambhA (Chandrashekaran and Sarla, 1993) stambha A
Secondary FlyBase IDs
	FBgn0003530 FBgn0025937 FBgn0060295
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...