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Gene Dmel\cv-c

General Information
Symbol	Dmel\cv-c	Species	D. melanogaster
Name	crossveinless c	Annotation symbol	CG34389
Feature type	protein_coding_gene	FlyBase ID	FBgn0086901
Gene Model Status	Current	Stock availability	48 publicly available
Also Known As	RhoGAP88C, l(3)06951, CG8480
Genomic Location
Chromosome (arm)	3R	Recombination map	3-54.1
Cytogenetic map	88B8-88C2	Sequence location	3R:10,217,405..10,307,435 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crossveinless c is referred to in FlyBase by the symbol Dmel\cv-c (CG34389, FBgn0086901). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activator activity. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; open tracheal system development; biological regulation; embryonic development via the syncytial blastoderm; digestive tract development; embryo development ending in birth or egg hatching; synaptic transmission; localization; post-embryonic organ morphogenesis; digestive system development. 50 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; organ system subdivision; non-connected developing system; cephalopharyngeal skeleton; late extended germ band embryo; thoracic segment; pharyngeal sclerite; embryonic hindgut; sense organ; portion of tissue. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Rho GTPase activation protein; Rho GTPase-activating protein domain; START domain; START-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:10217405..10307435.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cv-c: crossveinless-c Posterior crossvein usually absent or greatly reduced. Anterior crossvein usually present but often detached. Eye flattened or with vertical shallow furrow. Legs weak, especially tarsal joints. Occasionally overlaps wild type. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88B8-88C2   Limits computationally determined from genome sequence between P{lacW}trxj14A6&P{PZ}trx00347 and P{PZ}cv-c06951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88B-88C   Cytological location determined by SNP mapping.   (Denholm et al., 2005) 88C1-88C4   (determined by in situ hybridisation)   (Spradling et al., 1999) 88C1-88C4     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-54.1   3-57.9 (Edmondson, 1952)
Left of (cM)
Right of (cM)	red
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cv-c for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cv-c-RA FBtr0112631  NM_169583   4478   1017 cv-c-RC FBtr0112630  NM_001104316   9298   2351 cv-c-RD FBtr0112632  NM_001104318   8631   2351
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cv-c-PA   FBpp0111543   115.2   1017   9.95     NP_731907   AAF55053 cv-c-PC   FBpp0111542   255.9   2351   8.58     NP_001097786   ABW08670 cv-c-PD   FBpp0111544   255.9   2351   8.58     NP_001097788   ABW08671
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) START domain (IPR002913) Rho GTPase activation protein (IPR008936) START-like domain (IPR023393)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55053   AE014297 ABW08670   AE014297 ABW08671   AQ073336   AY075440 AAL68254   BE976267   BF506116   BI162967   BI162992   BI163006   BI169761   BI565279   BI617667   BI640194   BT031104   BT044146   CK132939   CO154557   CO155621   CO156211   CO178337   CO178498   CO185563   CO186511   CO187841   CO187842   CO283936   CO290124   CO290132   CO306113   CO306475   CO310636   CO315934   CO322910   CO337319   CO338560   CO341434   CO342243   CO343856   DQ327791   DQ327804   EC057383   EC068831   EC194468   EC195807   EC203319   EC213031   EC215259   EC225955   EC228893   EC229239   EC241663   EC254738   EC256231   EC259432   EC262423   EC264777   EC266484   EC267151   EC267590   EL881876   EL882113   GH754626   GH755362   GH757780   GH774131   GH793794   GH807463   GH813137   GH821950   GH829093   GH834997   GH857510   GH860153   GH872892   GH891235   GH894710   GH899198   GH901516   GH905680   GH908454   GH917215   GH920189   GH924622   GH927603
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFK2 A8JR05 Q8SY28
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval brain | restricted   (Pilgram et al., 2011) eye-antennal disc | restricted   (Pilgram et al., 2011) wing disc | restricted   (Pilgram et al., 2011) embryonic/larval hypodermal muscle   (Pilgram et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8  (28) carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8  28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    19 fat body, pupae P8    28 carcass, larvae L3 wandering    20 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr  (29) embryo 10-12hr    24 embryo 12-14hr  (29) embryo 14-16hr  (27) embryo 16-18hr    23 embryo 18-20hr  (27) embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new  (29) white prepupae 12hr  (46) white prepupae 24hr  (35) pupae 2d postWPP  (36) pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr  29 embryo 10-12hr    24 embryo 12-14hr  29 embryo 14-16hr  27 embryo 16-18hr    23 embryo 18-20hr  27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new  29 white prepupae 12hr  (46) white prepupae 24hr  (35) pupae 2d postWPP  (36) pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    15 embryo 06-08hr    22 embryo 08-10hr    29 embryo 10-12hr    24 embryo 12-14hr    29 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    27 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    23 white prepupae new    29 white prepupae 12hr    46 white prepupae 24hr    35 pupae 2d postWPP    36 pupae 3d postWPP    22 pupae 4d postWPP    20 adult male 01day    15 adult male 05day    17 adult male 30day    16 adult female 01day    6 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H  (28) embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8  (32) wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H  28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8  32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32  29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    10 embryonic 1182-4H    28 embryonic GM2    18 embryonic Kc167    11 embryonic S1    10 embryonic S3    8 leg disc CME L1    10 wing disc CME-W2    3 wing disc ML-DmD8    32 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    21 ovary fGS/OSS    13 ovary OSC    21 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • RE02250 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086901 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31330-RA;CG14847-RA;CG14846-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4αTub84B.PL cv-cdsRNA.Scer\UAS lethal | embryonic stage cv-c2 cv-c3 cv-c4 cv-c5 cv-c6 cv-c7 cv-c8 cv-c1260 cv-c06951 cv-cC524 cv-cJ8 cv-cJ17 cv-cM62 lethal | recessive cv-c06951 partially lethal - majority die, with Scer\GAL4pnr-MD237 cv-cGD5690 viable cv-c1 cv-cc viable, with Scer\GAL4pnr-MD237 cv-cGD8463 cv-cGD10227 cv-cGD10232 viable | reduced cv-cc Sterility Allele fertile cv-cc Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 cv-cGD5690 developmental rate defective cv-c7 cv-cM62 neuroanatomy defective cv-c1 neuroanatomy defective | embryonic stage cv-c1260 neuroanatomy defective | embryonic stage (with cv-c1260) cv-c06951 cv-cf04940 cv-cf07633 neuroanatomy defective | embryonic stage (with cv-c06951) cv-c1260 neuroanatomy defective | embryonic stage (with cv-cf04940) cv-c1260 neuroanatomy defective | embryonic stage (with cv-cf07633) cv-c1260 neurophysiology defective cv-c1 neurophysiology defective, with Scer\GAL4G14 cv-cdsRNA.Scer\UAS neurophysiology defective, with Scer\GAL4Rapgap1-OK6, cv-c1 cv-cScer\UAS.cDa neurophysiology defective, with Scer\GAL4Rapgap1-OK6, cv-cScer\UAS.cDa cv-c1 neurophysiology defective (with cv-c1) cv-cC524 cv-cM62 neurophysiology defective (with cv-cC524) cv-c1 neurophysiology defective (with cv-cM62) cv-c1 neurophysiology defective | dominant cv-c1 cv-cC524 cv-cM62 visible, with Scer\GAL4pnr-MD237 cv-cGD5690 visible, with Scer\GAL4T80 cv-cdsRNA.Scer\UAS visible | recessive cv-c1 cv-cM1 Phenotype manifest in Allele anterior crossvein cv-c1 cv-cM1 cv-cc anterior crossvein, with Scer\GAL4Bx-MS1096 cv-cdsRNA.Scer\UAS cortical actin cytoskeleton & embryonic posterior spiracle cv-c7 dendritic tree | embryonic stage cv-c1260 dorsal branch primordium cv-c7 dorsal bridge cv-cM62 dorsal closure embryo cv-c7 dorsal multidendritic neuron ddaC | embryonic stage cv-c1260 dorsal multidendritic neuron ddaC | embryonic stage (with cv-c1260) cv-c06951 cv-cf07633 cv-cf04940 dorsal multidendritic neuron ddaC | embryonic stage (with cv-c06951) cv-c1260 dorsal multidendritic neuron ddaC | embryonic stage (with cv-cf04940) cv-c1260 dorsal multidendritic neuron ddaC | embryonic stage (with cv-cf07633) cv-c1260 dorsal multidendritic neuron ddaD | embryonic stage cv-c1260 dorsal multidendritic neuron ddaE | embryonic stage cv-c1260 embryonic/first instar larval cuticle | dorsal cv-c7 cv-cM62 embryonic/larval midgut primordium cv-cM62 embryonic head cv-c7 embryonic leading edge cell cv-c1260 embryonic Malpighian tubule cv-cM62 embryonic Malpighian tubule, with Scer\GAL4ct.CtB cv-cScer\UAS.cDa embryonic Malpighian tubule tip cell, with Scer\GAL4ct.CtB cv-cScer\UAS.cDa embryonic trachea & cortical actin cytoskeleton cv-c7 eye cv-c1 filzkorper cv-cM62 hypostomal sclerite cv-cM62 leg cv-c1 median tooth cv-cM62 mesothoracic tergum, with Scer\GAL4pnr-MD237 cv-cGD5690 neuromuscular junction cv-c1 cv-cC524 cv-cM62 neuromuscular junction, with Scer\GAL4G14 cv-cdsRNA.Scer\UAS neuromuscular junction, with Scer\GAL4Rapgap1-OK6, cv-c1 cv-cScer\UAS.cDa neuromuscular junction, with Scer\GAL4Rapgap1-OK6, cv-cScer\UAS.cDa cv-c1 neuromuscular junction (with cv-c1) cv-cC524 cv-cM62 neuromuscular junction (with cv-cC524) cv-c1 neuromuscular junction (with cv-cM62) cv-c1 posterior crossvein cv-c1 cv-cM1 cv-cc posterior crossvein, with Scer\GAL4Bx-MS1096 cv-cdsRNA.Scer\UAS posterior crossvein (with cv-c1) cv-cM62 posterior crossvein (with cv-cM62) cv-c1 posterior spiracle primordium cv-c7 cv-cM62 posterior spiracle primordium, with Scer\GAL4ems.HRE cv-cScer\UAS.cDa presumptive embryonic/larval tracheal system cv-c7 primordium of embryonic/larval spiracle cv-c7 t-bar cv-c1 tracheal primordium cv-c7 trichogen cell, with Scer\GAL4pnr-MD237 cv-cGD5690 wing cv-cc wing vein L2, with Scer\GAL4T80 cv-cdsRNA.Scer\UAS wing vein L3 cv-cc wing vein L4 cv-cc
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of cv-c Class Mutagen Stocks Known lesion cv-c1 spontaneous 22 -- cv-cf04940 piggyBac transposase 2 -- cv-cf07633 piggyBac transposase 2 -- cv-c06951 P-element activity 1 Yes cv-cc00065 1 -- cv-cc01008 1 -- cv-ce03257 1 -- cv-cf01069 1 -- cv-cMB01956 1 -- cv-cMB03489 1 -- cv-cMB03717 1 -- cv-cMI00245 1 -- cv-cMI02122 1 -- cv-cMI03552 1 -- cv-cMI04045 1 -- cv-cM62 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cv-c1260 ethyl methanesulfonate 0 Yes cv-c2 ethyl methanesulfonate 0 -- cv-c3 ethyl methanesulfonate 0 -- cv-c4 ethyl methanesulfonate 0 -- cv-c5 ethyl methanesulfonate 0 -- cv-c6 ethyl methanesulfonate 0 -- cv-c7 antimorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cv-c8 ethyl methanesulfonate 0 -- cv-cC524 ethyl methanesulfonate 0 Yes cv-cc spontaneous 0 -- cv-cDG20401 0 -- cv-cJ17 Delta2-3 0 Yes cv-cJ8 Delta2-3 0 Yes cv-cM1 0 --
Alleles Carried on Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cv-c Class Mutagen Stocks Known lesion cv-cGD10232 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cv-cGD5690 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cv-cdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes cv-cGD10227 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-cGD8463 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-cKK102060 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-cKK107255 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-cKK111100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-cKK109519 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cv-cL.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-cL.Scer\UAS in vitro construct - regulatory fusion 0 Yes cv-cNIG.14847R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cv-cR601L.S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes cv-cS.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-cS.Scer\UAS in vitro construct - regulatory fusion 0 Yes cv-cScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes cv-cScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-cΔC.S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes cv-cΔN.S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes cv-cΔS.S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;1)O5 (Lindsley and Grell, 1958) Dp(3;3)E(var)88D11 (Green et al., 1990)
Disrupted in	Df(3R)Exel6267 (Ryder, 2004.4.26) Df(3R)kar5l (Green et al., 1990) Df(3R)red1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)red3l (Spradling et al., 1999, Green et al., 1990, BDGP Project Members, 1994-1999)
Not duplicated in	Dp(3;2)ry+ (Green et al., 1990)
Not disrupted in	Df(3R)c(3)G-2 (Nelson and Szauter, 1992) Df(3R)JY19 (Breen and Harte, 1991) Df(3R)Po2 (Nelson and Szauter, 1992) Df(3R)Po3 (Nelson and Szauter, 1992) Df(3R)Po4 (Nelson and Szauter, 1992) Df(3R)red2l (Breen and Harte, 1991) Df(3R)red-P1 (BDGP Project Members, 1994-1999) Df(3R)red-P6 (Breen and Harte, 1991, BDGP Project Members, 1994-1999) Df(3R)red-P52 (Breen and Harte, 1991) Df(3R)red-P93 (Breen and Harte, 1991) Df(3R)sbd26 (Nelson and Szauter, 1992) Df(3R)sbd45 (Nelson and Szauter, 1992) Df(3R)sbd105 (Nelson and Szauter, 1992) Df(3R)su(Hw)V (Breen and Harte, 1991) Df(3R)trxE12 (Breen and Harte, 1991) T(Y;3)redP4 (Breen and Harte, 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5690} NA P{GD8463} NA P{GD10227} NA P{GD10232} NA P{KK102060} NA P{KK107255} NA P{KK109519} NA P{KK111100} NA P{NIG.14847R} NA P{UAS-cv-c.D} NA P{UAS-cv-c.L.EGFP} NA P{UAS-cv-c.L} NA P{UAS-cv-c.S.EGFP} NA P{UAS-cv-c.S.R601L} NA P{UAS-cv-c.S.ΔC} NA P{UAS-cv-c.S.ΔN} NA P{UAS-cv-c.S.ΔS} NA P{UAS-cv-c.S} NA P{UAS-Venus-cv-c} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}cv-c06951 No miscellaneous insertions Mi{MIC}cv-cMI00245 NA Mi{MIC}cv-cMI02122 NA Mi{MIC}cv-cMI03552 NA Mi{MIC}cv-cMI04045 NA P{wHy}cv-cDG20401 NA PBac{PB}cv-cc00065 NA PBac{PB}cv-cc01008 NA PBac{RB}cv-ce03257 NA PBac{WH}cv-cf01069 NA PBac{WH}cv-cf04940 NA PBac{WH}cv-cf07633 NA insertion of enhancer trap binary system Mi{ET1}cv-cMB01956 No Mi{ET1}cv-cMB03489 No Mi{ET1}cv-cMB03717 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from mutant phenotype (Denholm et al., 2005)
Biological Process
CV term Evidence References
dorsal closure inferred from mutant phenotype (Denholm et al., 2005) epidermal growth factor receptor signaling pathway inferred from genetic interaction with Rho1 (Brodu and Casanova, 2006) epithelial cell migration, open tracheal system inferred from mutant phenotype (Brodu and Casanova, 2006) head involution inferred from mutant phenotype (Denholm et al., 2005) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Denholm et al., 2005, Pilgram et al., 2011) maintenance of epithelial integrity, open tracheal system inferred from mutant phenotype (Cela and Llimargas, 2006) Malpighian tubule morphogenesis inferred from mutant phenotype (Denholm et al., 2005) midgut development inferred from mutant phenotype (Denholm et al., 2005) neuromuscular synaptic transmission inferred from mutant phenotype (Pilgram et al., 2011) open tracheal system development inferred from mutant phenotype (Lovegrove et al., 2006) regulation of dendrite morphogenesis inferred from mutant phenotype (Sato et al., 2010) spiracle morphogenesis, open tracheal system inferred from mutant phenotype (Denholm et al., 2005, Simoes et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
Rho GTPase activator activity inferred from sequence or structural similarity with UniProtKB:Q9R0Z9 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cv-c allele Gene References unspecified Rac1 (Denholm et al., 2005) Rac2 (Denholm et al., 2005) rho (Sturtevant and Bier, 1995) Rho1 (Brodu and Casanova, 2006, Denholm et al., 2005) spi (Brodu and Casanova, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66825 DroID - A comprehensive database of gene and protein interactions. • FBgn0086901 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41749
Orthologs
OrthoDB Orthologs (32) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TMRMG Dipteran inclusive ortholog search EOG6D26XW Insect inclusive ortholog search EOG6228DV Arthropod inclusive ortholog search EOG6WM38S Metazoa inclusive ortholog search EOG63VBNG
Orthologs in Drosophila Species (EOG6TMRMG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cv-c     Drosophila simulans   Dsim\GD20423     Drosophila sechellia   Dsec\GM25854     Drosophila erecta   Dere\GG21328     Drosophila yakuba   Dyak\GE26453     Drosophila ananassae   Dana\GF17483     Drosophila pseudoobscura pseudoobscura   Dpse\GA16176     Drosophila persimilis   Dper\GL24017     Drosophila willistoni   Dwil\GK12150     Drosophila virilis   Dvir\GJ24451     Drosophila mojavensis   Dmoj\GI24807     Drosophila grimshawi   Dgri\GH13675
Orthologs in non-Drosophila Dipterans (EOG6D26XW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003220   Anopheles gambiae Malaria mosquito  Agam\AGAP005279   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001075
Orthologs in non-Dipteran Insects (EOG6228DV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47372   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009688   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11782   Atta cephalotes Leafcutter ant  Acep\ACEP27354   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20127   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20043   Linepithema humile Argentine ant  Lhum\LH13123   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17407   Solenopsis invicta Red fire ant  Sinv\SINV19308   Acyrthosiphon pisum Pea aphid  Apim\ACYPI38188   Acyrthosiphon pisum Pea aphid  Apim\ACYPI080860   Bombyx mori Silkmoth  Bmor\BGIBMGA010002   Pediculus humanus Human body louse  Phum\PHUM492460   Tribolium castaneum Red flour beetle  Tcas\TC004611
Orthologs in non-Insect Arthropods (EOG6WM38S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_310342   Ixodes scapularis Deer tick  Isca\ISCW005562
Orthologs in non-Arthropod Metazoa (EOG63VBNG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gei-1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 48 )
Bloomington	472 w1118; cv-c1
Harvard	- PBac{PB}cv-cc00065 - PBac{PB}cv-cc01008 - PBac{RB}cv-ce03257 - PBac{WH}cv-cf01069 - PBac{WH}cv-cf04940 - PBac{WH}cv-cf07633
Kyoto	105929 cv-c1
VDRC	v100247 P{KK107255}VIE-260B v102207 P{KK111100}VIE-260B v105435 P{KK102060}VIE-260B v16786 w1118; P{GD5690}v16786
	More stocks available...
Genomic Clones ( 2 )
	BACR04O02 BACR26A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE02250
Other clones	FI03409 IP11791
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08508 RE02279 RE02293 RH48069 RH63013 SD23004
Other clones	80184 119624 144258 160243 214435.33 214477.32 214537.38 523875 525058 527258 568966 572796 bs48g06 CK01.6A.F5 CK01.6D.G9 CK01.22A.C12 CK01.22C.H1 CK01.71A.B6 CK01.71D.D1 EK010220 EK020442 EK034002 EK034005 EK056439 EK056910 EK073120 EK073132 EK164838 EK189205 EK222202 EK250264 EK251140 EK263145 EN04348 EN06435 EN07558 EN14252 EN17063 EP12436 EP14258 EP18233 IP11691 IP11891 RE11031 RP003009915 RP003048758 RP003052687 RP003099893 RP003104203 RP003130203 RP003132114 RP003145958 RP003146145 RP003205459 RP003225025 RP003253425 RP003257743 RP003278626 RP003292235 RP003297713 RP003341805 RP003352468 RP003416937 RP003465421 RP003540096 RP003586587 RP003632085
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086901 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41749
Antibody Information
Other Information
Discoverer
	Stern, 13th July 1925.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG14845 RhoGAP88C (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG14848 CG14849 (FlyBase Genome Annotators, 2002-2003) Source for merge of: cv-c CG31330 CG14847 CG14846 (FlyBase Genome Annotators, 2007) Source for merge of: cv-c RhoGAP88C l(3)06951 (Denholm et al., 2005)
Additional comments	Annotations CG31319, CG31330, CG14847 and CG14846 merged as CG34389 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) Annotations CG14845 and CG8480 merged as CG31319 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Annotations CG14848 and CG14849 merged as CG31330 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	cv-c is a mediator of trh and Egfr-induced invagination. (Brodu and Casanova, 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Loss of vein mutations cause suppression of rhohs.PSt ectopic vein phenotype and enhancement of the rhove-1 loss of vein phenotype. (Sturtevant and Bier, 1995) Mutations in cv-c remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab. (Diaz-Benjumea and Garcia-Bellido, 1990) ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation. (Diaz-Benjumea et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169583 NM_001104316 NM_001104318 RefSeq (Proteins) • NP_731907 NP_001097786 NP_001097788 DDBJ / EMBL / GenBank • AAF55053 AAL68254 ABW08670 ABW08671 AQ073336 AY075440 BI162967 DQ327791 DQ327804 Entrez Gene - A searchable database of RefSeq genes. • 41749 UniProtKB/TrEMBL • A8JR05 Q8SY28 Q9VFK2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) START domain (IPR002913) Rho GTPase activation protein (IPR008936) START-like domain (IPR023393) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE02250
Linkouts
	BioGRID - A database of protein and genetic interactions • 66825 DroID - A comprehensive database of gene and protein interactions. • FBgn0086901 DRSC - Results from RNAi screens. • FBgn0086901 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086901 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31330-RA;CG14847-RA;CG14846-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086901 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41749 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/crossvnlsc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41749 modMine - Data generated by the modENCODE project. • FBgn0086901
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG8480 (Bernards, 2003, Billuart et al., 2001, ) CG14845   CG14846   CG14847   CG14848 (Furlong et al., 2001, ) CG14849   CG31319   CG31330 (Manak et al., 2006) CG34389 (FlyBase Genome Annotators, 2007, Greenberg and Hatini, 2011, Sato et al., 2010, Keleman et al., 2009.8.5) cv-c (Denholm et al., 2005, Cela and Llimargas, 2006, Simoes et al., 2006, Lovegrove et al., 2006, Campbell et al., 2010, Hughes and Marcus, 2008, Greenberg and Hatini, 2011, Sato et al., 2010, Pilgram et al., 2011, Wasbrough et al., 2010, Mackay et al., 2012, Japanese National Institute of Genetics, 2012.5.21) l(3)06951 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) RhoGAP88C (Hughes and Marcus, 2008, Kolesnikov and Beckendorf, 2007, Manak et al., 2006, Zeitlinger et al., 2007, Manak et al., 2006, Ferjoux et al., 2007) rhoGAP88C (Magalhaes et al., 2007)
Name Synonym	CG14846   CG14847   CG31330   crossveinless-c (Brodu and Casanova, 2006, Hughes and Marcus, 2008, Sato et al., 2010, Manak et al., 2006, Pilgram et al., 2011) crossveinless c   Crossveinless-c (Kolesnikov and Beckendorf, 2007) lethal (3) 06951
Secondary FlyBase IDs
	FBgn0000397 FBgn0010910 FBgn0038226 FBgn0038227 FBgn0038228 FBgn0038231 FBgn0038232 FBgn0040560 FBgn0051319 FBgn0051330 FBgn0085418 FBgn0086696
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 8 ) Review  ( 3 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 5 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Mackay et al., 2012, Nature 482(7384): 173--178 The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Greenberg and Hatini, 2011, Mech. Dev. 128(1-2): 5--17 Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. [FBrf0212976] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...