• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\kis

General Information
Symbol	Dmel\kis	Species	D. melanogaster
Name	kismet	Annotation symbol	CG3696
Feature type	protein_coding_gene	FlyBase ID	FBgn0086902
Gene Model Status	Current	Stock availability	54 publicly available
Also Known As	l(2)k16510, KIS-L
Genomic Location
Chromosome (arm)	2L	Recombination map	2-0
Cytogenetic map	21B4-21B5	Sequence location	2L:210,735..250,823 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent helicase activity. There is experimental evidence for 13 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; biological regulation; regionalization; neuron differentiation; multicellular organismal development; immune response; localization; determination of adult lifespan; post-embryonic organ morphogenesis; segment specification; short-term memory. 150 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; trichogen cell; mesothoracic tergum; wing; imaginal disc; wing vein. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: BRK domain; Chromo domain; Chromo domain-like; Chromo domain/shadow; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636513_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of kis. Gene sequence location is 2L:210735..250823.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	kis: kismet (J.A. Kennison) Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b, and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity. kisS: kismet-Spradling
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21B4-21B5   Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21B6-21B8   Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).   (Kennison and Tamkun, 1988) 21B6-21B7     (Therrien, 1999.12.13) 21B6-21B7     (Daubresse, 1998.12.14) 21B4-21B6   (determined by in situ hybridisation) 21C1--2 (determined by in situ hybridisation)   (Spradling et al., 1999) 21B-21B   (determined by in situ hybridisation)   (Roch et al., 1998) 21B-21B     (Gellon et al., 1997) 21B4-21B6   21B4--7 21B6--7 21B7--8 21C1--2   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-0 (Kennison and Tamkun, 1988)
Left of (cM)
Right of (cM)	net
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\kis for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kis-RA FBtr0078144  NM_078717   17943   5322 kis-RB FBtr0078145  NM_164376   8225   2151 kis-RC FBtr0299837  NM_001144289   18528   5517 kis-RD FBtr0308253  NM_001258889   18006   5343 kis-RE FBtr0308254  NM_001258890   17733   5252 kis-RF FBtr0308255  NM_001258891   17731   5191
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein kis-PA   FBpp0077803   573.6   5322   5.52     NP_523441   AAF51527 kis-PB   FBpp0077804   224.7   2151   6.10     NP_722617   AAF51530 kis-PC   FBpp0289115   593.4   5517   5.34     NP_001137761   ACL82968 kis-PD   FBpp0300573   575.9   5343   5.56     NP_001245818   AFH03495 kis-PE   FBpp0300574   566.1   5252   5.53     NP_001245819   AFH03496 kis-PF   FBpp0300575   560.9   5191   5.53     NP_001245820   AFH03497
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) SNF2-related (IPR000330) Chromo domain/shadow (IPR000953) Helicase, C-terminal (IPR001650) BRK domain (IPR006576) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) Chromo domain-like (IPR016197) Chromo domain (IPR023780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141866   AA141867   AA390965   AA540945   AA567240   AA696166   AA696168   AA696213   AA941494   AE014134 AAF51527   AE014134 AAF51530   AE014134 ACL82968   AF113847 AAD37500   AF215703 AAF43004   AE014134 AFH03495   AE014134 AFH03496   AE014134 AFH03497   AI064684   AI259652   AI533719   AI546323   AQ024954   AQ025961   AQ026108   AQ073293   AQ073424   AQ073555   AQ073613   AQ073679   AW941927   AW942085   AW944430   AX260202   AX482637   AY075355   BG638449   BG639244   BH023743   BI632898   BP542813   BP542814   BP555433   BP555434   BQ103608   BT011123   BT031109   CK131656   CK135370   CK658985   CO156057   CO187917   CO190732   CO191629   CO196647   CO264308   CO273894   CO276480   CO276507   CO282769   CO283643   CO284103   CO292527   CO292807   CO293259   CO299972   CO300566   CO304174   CO306261   CO309811   CO312187   CO316242   CO322688   CO325960   CO331040   CO332824   CO339768   CO339961   CO343735   CW848212   CZ467381   CZ468734   CZ472577   CZ472578   CZ474154   CZ474492   CZ476266   CZ478623   CZ479719   CZ481984   CZ482370   CZ482371   CZ488213   CZ489256   EC057590   EC061071   EC067874   EC073590   EC076501   EC076778   EC077856   EC079928   EC079929   EC083442   EC198488   EC201130   EC203214   EC203332   EC205048   EC209074   EC219370   EC221986   EC222709   EC224220   EC228774   EC229509   EC229510   EC235041   EC237045   EC237694   EC238877   EC246089   EC247983   EC252025   EC253037   EC253775   EC255002   EC258841   EC267573   EL873954   EL884488   EL884722   EL884723   ES696546   EV575361   EV583225   EV586409   EV586517   EV586714   EV589160   EV589753   EV590404   EV591787   EV595402   EV596632   GH941746   GH943768   GH947144   GH948476   GH948845   GH957078   GH960613   GH964646   GH965093   GH966766   GH966923   GH967399   GH971609   GH980345   GH980901   GH982686
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPL6 Q9VPL9 B7Z002 Q9Y1L3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell   • cytoplasm | basal (Lecuyer et al., 2007) epithelium   • cytoplasm | basal (Lecuyer et al., 2007) embryonic stage 1 -- 11   organism | ubiquitous & uniform   (Daubresse et al., 1999) embryonic stage 16 -- 17   embryonic/larval central nervous system   (Daubresse et al., 1999) Comment:expression is uniform along A/P axis northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage   organism   (Daubresse et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 9   organism   • nucleus (Daubresse et al., 1999) third instar larval stage   imaginal disc   • nucleus (Daubresse et al., 1999) Comment:NOT labial disc embryonic/larval salivary gland   • nucleus (Daubresse et al., 1999) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Daubresse et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Clyne et al., 2003)
Expression Deduced from Reporters
Reporter: P{PZ}kis07812 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | segmentally repeated   (Jackle and Janning, 1998.8.10) embryonic/larval midgut   (Jackle and Janning, 1998.8.10) embryonic/larval foregut   (Jackle and Janning, 1998.8.10) embryonic/larval brain | presumptive   (Jackle and Janning, 1998.8.10) stomodeum   (Jackle and Janning, 1998.8.10) presumptive embryonic/larval central nervous system | restricted   (Jackle and Janning, 1998.8.10) ectoderm   (Jackle and Janning, 1998.8.10) presumptive embryonic/larval peripheral nervous system   (Jackle and Janning, 1998.8.10) embryonic/larval hindgut   (Jackle and Janning, 1998.8.10) amnioserosa   (Jackle and Janning, 1998.8.10) epidermis | restricted   (Jackle and Janning, 1998.8.10) cephalic furrow   (Jackle and Janning, 1998.8.10) embryonic/larval proventriculus   (Jackle and Janning, 1998.8.10) mesoderm   (Jackle and Janning, 1998.8.10) embryonic stage 5     (Jackle and Janning, 1998.8.10) wandering third instar larval stage   gonad   (Meister and Braun, 1995.10) embryonic/larval hindgut   (Meister and Braun, 1995.10) adult stage   adult central complex | restricted   (Vosshall, 1998.8.10) adult brain | restricted   (Vosshall, 1998.8.10)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1101.725 Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1101.725) Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea  (723.5) Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain  (993.2) Adult Thoracic-Abdominal Ganglion  (706.6) Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1101.725) Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1101.725 Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1101.725 Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1101.725) Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea  723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain  (993.2) Adult Thoracic-Abdominal Ganglion  706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1101.725 Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1101.725 Larval Midgut    179.7 Larval Hindgut    342 Larval Malpighian Tubules    327.1 Larval Fat Body    293.2 Larval Salivary Gland    398.4 Larval Trachea    723.5 Larval Carcass    340.35 Adult Head    287.2 Adult Eye    499.25 Adult Brain    993.2 Adult Thoracic-Abdominal Ganglion    706.6 Adult Crop    408.9 Adult Midgut    176.2 Adult Hindgut    354.4 Adult Malpighian Tubules    431.1 Adult Fat Body    293.8 Adult Salivary Gland    456.7 Adult Heart    334.25 Adult VirginFemale Spermatheca    305.1 Adult InseminatedFemale Spermatheca    365.9 Adult Ovary    389.5 Adult Testis    59.4 Adult Male Accessory Gland    254.9 Adult Carcass    227.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    287.2   NA  Eye    499.25   NA  Brain    993.2   1101.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    706.6   NA  Crop    408.9   179.7  Midgut    176.2   342  Hindgut    354.4   327.1  Malpighian Tubules    431.1   293.2  Fat Body    293.8   398.4  Salivary Gland    456.7   NA  Heart    334.25   723.5  Trachea    NA   NA  VirginFemale Spermatheca    305.1   NA  InseminatedFemale Spermatheca    365.9   NA  Ovary    389.5   NA  Testis    59.4   NA  Male Accessory Gland    254.9   340.35  Carcass    227.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  (90) central nervous system, pupae P8  (62) head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male  (28) head, mated 4-day male  (28) head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering  (41) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (55) testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  (90) central nervous system, pupae P8  (62) head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male  28 head, mated 4-day male  28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering  (41) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (55) testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    90 central nervous system, pupae P8    62 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    19 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    28 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    10 fat body, white prepupae    18 fat body, pupae P8    20 carcass, larvae L3 wandering    41 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    10 ovary, virgin 4-day female    58 ovary, mated 4-day female    55 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr  (57) embryo 04-06hr  (63) embryo 06-08hr  (61) embryo 08-10hr  (47) embryo 10-12hr    14 embryo 12-14hr  (34) embryo 14-16hr  26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (27) white prepupae new  26 white prepupae 12hr    24 white prepupae 24hr  (38) pupae 2d postWPP  (33) pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day  (42) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr  (57) embryo 04-06hr  (63) embryo 06-08hr  (61) embryo 08-10hr  (47) embryo 10-12hr    14 embryo 12-14hr  (34) embryo 14-16hr  26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  27 white prepupae new  26 white prepupae 12hr    24 white prepupae 24hr  (38) pupae 2d postWPP  (33) pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day  (42) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    57 embryo 04-06hr    63 embryo 06-08hr    61 embryo 08-10hr    47 embryo 10-12hr    14 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    24 embryo 22-24hr    21 larva L1    12 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    27 white prepupae new    26 white prepupae 12hr    24 white prepupae 24hr    38 pupae 2d postWPP    33 pupae 3d postWPP    12 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    42 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3  26 leg disc CME L1    10 wing disc CME-W2  (27) wing disc ML-DmD8  (30) wing disc ML-DmD9  (40) wing disc ML-DmD16-c3  (46) wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  (27) antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  (35) ovary fGS/OSS  (50) ovary OSC  (57) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3  26 leg disc CME L1    10 wing disc CME-W2  27 wing disc ML-DmD8  30 wing disc ML-DmD9  (40) wing disc ML-DmD16-c3  (46) wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  (35) ovary fGS/OSS  (50) ovary OSC  (57) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    24 embryonic Kc167    9 embryonic S1    17 embryonic S3    26 leg disc CME L1    10 wing disc CME-W2    27 wing disc ML-DmD8    30 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    1 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    35 ovary fGS/OSS    50 ovary OSC    57 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086902
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD kisGS2067 lethal, with Scer\GAL4c355 kisGS2067 lethal, with Scer\GAL4dpp.blk1 kisGS2067 lethal, with Scer\GAL4hs.2sev kisGS2067 lethal | larval stage | recessive kisk04513 kisk08827 lethal | pupal stage, with Scer\GAL4da.G32 kisGD16331 lethal | pupal stage, with Scer\GAL4elav-C155 kisGD16331 lethal | recessive kis1 kis2 kis2L-89-19 kis3 kis4 kis5 kis6 kis7 kis8 kis9 kis02532 kis03303 kis04256 kis05148 kis05841 kis07812 kis07815 kis10464 kisk05630 kisk05708 kisk05827 kisk06119 kisk06919 kisk08319 kisk08814 kisk09023 kisk09105 kisk09111 kisk09846 kisk10409 kisk11324 kisk13416 kisk13631 kisk14112 kisk14905 kisk16510 kisk16521 kisrL432 kisS353 kiss3527 kiss4771 kiss4793 kisS kisunspecified viable kisCC00801 kisCC01466 kisEY12846 kisk10237 kisWee-P2 viable, with Scer\GAL4da.G32 kisGD4510 viable, with Scer\GAL4elav-C155 kisGD4510 viable, with Scer\GAL4pnr-MD237 kisGD4510 kisGD16331 Sterility Allele fertile kisEY12846 Other Phenotypes Allele flightless, with Scer\GAL4da.G32 kisGD4510 locomotor behavior defective | adult stage, with Scer\GAL4c309 kisGD16331 locomotor behavior defective | adult stage, with Scer\GAL4da.G32 kisGD4510 locomotor behavior defective | adult stage, with Scer\GAL4DJ757 kisGD16331 locomotor behavior defective | adult stage, with Scer\GAL4OK307 kisGD16331 long lived, with Scer\GAL4da.Switch.PT kisGX2970 kisGX6561 memory defective, with Scer\GAL4ey-OK107 kisGD4510 kisGD16331 neuroanatomy defective | adult stage | somatic clone kisLM27 neuroanatomy defective | pupal stage | somatic clone kisLM27 neuroanatomy defective | somatic clone | third instar larval stage kisLM27 suppressor of variegation, with Dp(?;2)bwD, Scer\GAL4GMR.PF kisEY12846 visible, with Scer\GAL4ap-md544 kisNIG.3696R visible, with Scer\GAL4Bx-MS1096 kisNIG.3696R visible, with Scer\GAL4da.G32 kisGD4510 visible, with Scer\GAL4elav-C155 kisGD4510 visible, with Scer\GAL4GMR.PF kisGD16331 visible, with Scer\GAL4pnr-MD237 kisGD4510 kisGD16331 visible | cell autonomous | homeotic | recessive | somatic clone kis2 visible | homeotic | recessive | somatic clone kis1 kisS visible | recessive kisk08827 visible | recessive | somatic clone kis1 kis29D4 kis59C3 kis61C kis165A1 kis172A3 visible | somatic clone kis1 Phenotype manifest in Allele 1st posterior cell | somatic clone kis172A3 kis165A1 kis61C kis29D4 kis59C3 kis1 adult abdominal segment 5 | cell autonomous | somatic clone kis1 kis2 kisS border follicle cell | somatic clone kisPBac911 kisPBac5201 cephalopharyngeal skeleton | germline clone kis1 denticle belt | germline clone kis1 dorsal cluster neuron | adult stage | somatic clone kisLM27 dorsal cluster neuron | somatic clone | third instar larval stage kisLM27 embryonic abdominal segment 2 | germline clone kis1 embryonic abdominal segment 4 | germline clone kis1 embryonic abdominal segment 6 | germline clone kis1 embryonic abdominal segment 8 | germline clone kis1 embryonic head | germline clone kis1 embryonic head | germline clone | maternal effect kis2L-89-19 embryonic mesothoracic segment | germline clone kis1 embryonic metathoracic segment | germline clone kis1 embryonic segment | germline clone | maternal effect kis2L-89-19 eye, with Scer\GAL4GMR.PF kisGD16331 eye | somatic clone kis1 eye photoreceptor cell | somatic clone | third instar larval stage kisLM27 imaginal disc kisk04513 kisk08827 larval mesothoracic sensillum | embryonic stage | germline clone kis1 larval metathoracic sensillum | embryonic stage | germline clone kis1 leg kisk08827 macrochaeta | supernumerary, with Scer\GAL4elav-C155 kisGD4510 mesothoracic tergum, with Scer\GAL4pnr-MD237 kisGD16331 mesothoracic ventral denticle belt | germline clone kis1 metathoracic femur | somatic clone kis1 kisS metathoracic Keilin's organ | germline clone kis1 metathoracic leg | somatic clone kis1 kisS metathoracic metatarsus | somatic clone kis1 kisS metathoracic tarsal segment 2 | somatic clone kis1 kisS metathoracic tarsal segment 3 | somatic clone kis1 kisS metathoracic tarsal segment 4 | somatic clone kis1 kisS metathoracic tarsal segment 5 | somatic clone kis1 kisS metathoracic tibia | somatic clone kis1 kisS metathoracic ventral denticle belt | germline clone kis1 mushroom body alpha-lobe | adult stage | somatic clone kisLM27 mushroom body beta-lobe | adult stage | somatic clone kisLM27 mushroom body gamma-lobe | adult stage | somatic clone kisLM27 mushroom body gamma-lobe | pupal stage | somatic clone kisLM27 prothoracic leg | anterior compartment | somatic clone kisS prothoracic tibial transverse row bristle | somatic clone kisS sex comb | somatic clone kisS trichogen cell, with Scer\GAL4pnr-MD237 kisGD4510 kisGD16331 wing, with Scer\GAL4da.G32 kisGD4510 wing | somatic clone kis172A3 kis165A1 kis61C kis59C3 kis1 wing vein, with Scer\GAL4ap-md544 kisNIG.3696R wing vein | ectopic, with Scer\GAL4Bx-MS1096 kisNIG.3696R wing vein | ectopic, with Scer\GAL4elav-C155 kisGD4510 wing vein | ectopic | somatic clone kis172A3 kis165A1 kis61C kis59C3 kis1
Classical Alleles ( 142 )
For All Classical Alleles Show
Allele of kis Class Mutagen Stocks Known lesion kis1 loss of function allele ethyl methanesulfonate 2 -- kisBG01657 P-element activity 2 -- kisk10237 P-element activity 2 -- kisk11324 P-element activity 2 -- kisk13416 P-element activity 2 -- kisKG08523 2 -- kis5-HA-1148 1 -- kis5-HA-1614 1 -- kis5-HA-1691 1 -- kis5-HA-2299 1 -- kis5-HA-2916 1 -- kis5-HA-3065 1 -- kis5-SZ-3153 1 -- kisc01706 piggyBac transposase 1 -- kisc03567 piggyBac transposase 1 -- kisCB-6339-3 1 -- kisd04820 P-element activity 1 -- kisd05370 P-element activity 1 -- kise00780 piggyBac transposase 1 -- kise04240 piggyBac transposase 1 -- kise04609 piggyBac transposase 1 -- kisEY12846 P-element activity 1 Yes kisf05612 piggyBac transposase 1 -- kisf06548 piggyBac transposase 1 -- kisGS2067 Delta2-3 1 Yes kisk05630 P-element activity 1 -- kisk14112 P-element activity 1 -- kisk16510 P-element activity 1 -- kisMI00231 1 -- kisMI03782 1 -- kisNP0372 1 -- kisNP0680 1 -- kisNP1119 1 -- kisNP1229 1 -- kisNP2452 1 -- kisNP3385 1 -- kisNP4283 1 -- kisNP4672 1 -- kisNP5207 1 -- kisNP6217 1 -- kisNP7058 1 -- kisNP7337 1 -- kisUM-8106-3 1 -- kisUM-8357-3 1 -- kis02532 P-element activity 0 -- kis03303 P-element activity 0 -- kis04256 P-element activity 0 -- kis05148 P-element activity 0 -- kis05841 P-element activity 0 -- kis06301 P-element activity 0 -- kis07812 P-element activity 0 -- kis07815 P-element activity 0 -- kis10464 P-element activity 0 -- kis165A1 ethyl nitrosourea 0 -- kis172A3 ethyl nitrosourea 0 -- kis29D4 ethyl nitrosourea 0 -- kis2 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- kis2L-89-19 ethyl methanesulfonate 0 -- kis3 ethyl methanesulfonate 0 -- kis4 ethyl methanesulfonate 0 -- kis5-HA-2968 0 -- kis5-HA-3087 0 -- kis59C3 ethyl nitrosourea 0 -- kis5 ethyl methanesulfonate 0 -- kis61C ethyl nitrosourea 0 -- kis6 ethyl methanesulfonate 0 -- kis7 ethyl methanesulfonate 0 -- kis8 ethyl methanesulfonate 0 -- kis9 gamma ray 0 -- kisAO9 ethyl methanesulfonate 0 -- kisAS21 ethyl methanesulfonate 0 -- kisCB-5283-3 0 -- kisCC00801 P-element activity 0 Yes kisCC01466 P-element activity 0 Yes kisCPTI002847 piggyBac transposase 0 Yes kisCPTI003576 piggyBac transposase 0 Yes kisCPTI003615 piggyBac transposase 0 Yes kisd02029 P-element activity 0 -- kisd08502 P-element activity 0 -- kisDG16402 P-element activity 0 -- kise01907 piggyBac transposase 0 -- kiseAL7 X ray 0 -- kiseB15 ethyl methanesulfonate 0 -- kiseBA8 ethyl methanesulfonate 0 -- kiseBD10 ethyl methanesulfonate 0 -- kisEC1 ethyl methanesulfonate 0 -- kiseCM2 ethyl methanesulfonate 0 -- kiseCV2 ethyl methanesulfonate 0 -- kiseDO1 ethyl methanesulfonate 0 -- kiseDV6 ethyl methanesulfonate 0 -- kiseE4 ethyl methanesulfonate 0 -- kiseEA2 ethyl methanesulfonate 0 -- kiseG2 ethyl methanesulfonate 0 -- kiseI7 ethyl methanesulfonate 0 -- kiseJ6 ethyl methanesulfonate 0 -- kiseK15 ethyl methanesulfonate 0 -- kiseP18 X ray 0 -- kisEP2240 P-element activity 0 Yes kisEP2288 P-element activity 0 Yes kisEP2401 P-element activity 0 -- kisEP2469 P-element activity 0 -- kisEP2473 0 -- kisEP2548 P-element activity 0 -- kisEP497 P-element activity 0 Yes kisEP563 P-element activity 0 Yes kisGS9968 0 Yes kisGX2970 Delta2-3 0 Yes kisGX6561 Delta2-3 0 -- kisk04513 P-element activity 0 -- kisk05708 P-element activity 0 -- kisk05827 P-element activity 0 -- kisk06022 P-element activity 0 -- kisk06119 P-element activity 0 -- kisk06919 P-element activity 0 -- kisk07816 0 -- kisk08319 P-element activity 0 -- kisk08814 P-element activity 0 -- kisk08827 P-element activity 0 -- kisk09023 P-element activity 0 -- kisk09105 P-element activity 0 -- kisk09111 P-element activity 0 -- kisk09846 P-element activity 0 -- kisk10409 P-element activity 0 -- kisk13631 P-element activity 0 -- kisk14905 P-element activity 0 -- kisk16521 P-element activity 0 -- kisLA4.3 P-element activity 0 -- kisLM27 ethyl methanesulfonate 0 -- kisNP4667 0 -- kisNP6312 0 -- kisPBac5201 piggyBac transposase 0 Yes kisPBac911 piggyBac transposase 0 Yes kisrL432 P-element activity 0 -- kiss3527 P-element activity 0 -- kisS353 P-element activity 0 Yes kiss4771 P-element activity 0 -- kiss4793 P-element activity 0 -- kisS loss of function allele P-element activity 0 -- kisSH0248 0 -- kisSH1047 0 -- kisunspecified 0 -- kisWee-P2 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of kis Class Mutagen Stocks Known lesion kisGD16331 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kisGD4510 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kisGL00557 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kisHMS01254 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kisisozakB in vitro construct - genomic fragment 0 Yes kisKK100890 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kisNIG.18326R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kisNIG.3696R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7002 (Ryder, 2004.4.26) Df(2L)net-PMC (Daubresse et al., 1999) Df(2L)net-PMF (Netter et al., 1998, Daubresse et al., 1999, Spradling et al., 1999, Therrien et al., 2000, BDGP Project Members, 1994-1999) Df(2R)Px2 (BDGP Project Members, 1994-1999)
Duplicated in	Dp(2;1)L124 (Daubresse et al., 1999) Ts(YLt;2Lt)L124 (Srinivasan et al., 2005)
Not disrupted in	Df(2L)al (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)net62 (Therrien et al., 2000) Df(2L)net-PM29A (Daubresse et al., 1999) Df(2L)net-PM47C (Daubresse et al., 1999, BDGP Project Members, 1994-1999) Df(2L)net-PMF (BDGP Project Members, 1994-1999) Df(2L)TE21A (Daubresse et al., 1999) Df(2L)TW1 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4510} NA P{GD16331} NA P{KK100890} NA P{NIG.18326R} NA P{TRiP.GL00557} NA P{TRiP.HMS01254} NA characterization construct P{kisisozakB} NA P{NIG.3696R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}kisk04513 No P{lacW}kisk05630 No P{lacW}kisk05708 No P{lacW}kisk05827 No P{lacW}kisk06022 No P{lacW}kisk06119 No P{lacW}kisk06919 No P{lacW}kisk08319 No P{lacW}kisk08814 No P{lacW}kisk08827 No P{lacW}kisk09023 No P{lacW}kisk09105 No P{lacW}kisk09111 No P{lacW}kisk09846 No P{lacW}kisk10237 No P{lacW}kisk10409 No P{lacW}kisk11324 No P{lacW}kisk13416 No P{lacW}kisk13631 No P{lacW}kisk14112 No P{lacW}kisk14905 No P{lacW}kisk16510 No P{lacW}kisk16521 No P{lacW}kiss3527 No P{lacW}kiss4771 No P{lacW}kiss4793 No P{lacW}kisSH0248 No P{lacW}kisSH1047 No P{lacW}l(2)SH0896SH0896 No P{lacW}l(2)SH1579SH1579 No P{PZ}kis02532 No P{PZ}kis03303 No P{PZ}kis04256 No P{PZ}kis05148 No P{PZ}kis05841 No P{PZ}kis06301 No P{PZ}kis07812 No P{PZ}kis07815 No P{PZ}kis10464 No P{PZ}kisrL432 No insertion of mobile activating element P{EP}kisEP497 NA P{EP}kisEP563 NA P{EP}kisEP2240 NA P{EP}kisEP2288 NA P{EP}kisEP2401 NA P{EP}kisEP2469 NA P{EP}kisEP2473 NA P{EP}kisEP2548 NA P{EP}kisGX2970 NA P{EP}kisGX6561 NA P{EPgy2}kisEY12846 NA P{GSV1}kisGS2067 NA P{GSV6}kisGS9968 NA P{Mae-UAS.6.11}B0193B0193 NA P{Mae-UAS.6.11}kisLA4.3 NA P{XP}kisd02029 NA P{XP}kisd04820 NA P{XP}kisd05370 NA P{XP}kisd08502 NA miscellaneous insertions Mi{MIC}kisMI00231 NA Mi{MIC}kisMI03782 NA P{GT1}kisBG01657 NA P{PTT-GC}kisCC00801 NA P{PTT-GC}kisCC01466 NA P{RS3}kisCB-5283-3 NA P{RS3}kisCB-6339-3 NA P{RS3}kisUM-8106-3 NA P{RS3}kisUM-8357-3 NA P{RS5}kis5-HA-1148 NA P{RS5}kis5-HA-1614 NA P{RS5}kis5-HA-1691 NA P{RS5}kis5-HA-2299 NA P{RS5}kis5-HA-2916 NA P{RS5}kis5-HA-2968 NA P{RS5}kis5-HA-3065 NA P{RS5}kis5-HA-3087 NA P{RS5}kis5-SZ-3153 NA P{ry11}kisS NA P{SUPor-P}kisKG08523 NA P{Wee-P.ph0}kisWee-P2 NA P{wHy}kisDG16402 NA PBac{768.FSVS-0}kisCPTI003576 NA PBac{768.FSVS-0}kisCPTI003615 NA PBac{CPTI-un}kisCPTI002847 NA PBac{IRES-GFP.GT}kisPBac911 NA PBac{IRES-GFP.GT}kisPBac5201 NA PBac{PB}kisc01706 NA PBac{PB}kisc03567 NA PBac{RB}kise00780 NA PBac{RB}kise01907 NA PBac{RB}kise04240 NA PBac{RB}kise04609 NA PBac{WH}kisf05612 NA PBac{WH}kisf06548 NA insertion of enhancer trap binary system P{GalW}kisS353 No P{GawB}kisNP0372 No P{GawB}kisNP0680 No P{GawB}kisNP1119 No P{GawB}kisNP1229 No P{GawB}kisNP2452 No P{GawB}kisNP3385 No P{GawB}kisNP4283 No P{GawB}kisNP4667 No P{GawB}kisNP4672 No P{GawB}kisNP5207 No P{GawB}kisNP6217 No P{GawB}kisNP6312 No P{GawB}kisNP7058 No P{GawB}kisNP7337 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) axon guidance inferred from mutant phenotype (Berger et al., 2008, Melicharek et al., 2010) blastoderm segmentation inferred from mutant phenotype (Daubresse et al., 1999) border follicle cell migration inferred from mutant phenotype (Mathieu et al., 2007) determination of adult lifespan inferred from mutant phenotype (Paik et al., 2012) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Terriente-Félix et al., 2011) locomotion inferred from mutant phenotype (Melicharek et al., 2010) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Terriente-Félix et al., 2011) neuron remodeling inferred from mutant phenotype (Melicharek et al., 2010) peroxisome organization inferred from mutant phenotype (Mast et al., 2011) positive regulation of organ growth inferred from mutant phenotype (Terriente-Félix et al., 2011) segment specification inferred from mutant phenotype (Daubresse et al., 1999) short-term memory inferred from mutant phenotype (Melicharek et al., 2010)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Clyne et al., 2003)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001650 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from sequence or structural similarity with InterPro:IPR001410 (FlyBase, 1992-) DNA binding inferred from electronic annotation with InterPro:IPR000330 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR000953 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
kis - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) kis - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) kis - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions kis allele Gene References kis1 Pc (Kennison and Tamkun, 1988) Snr1 (Marenda et al., 2004) tna (Gutierrez et al., 2003) kis2 corto (Lopez et al., 2001) Pc (Kennison and Tamkun, 1988) w (Bloyer et al., 2003) kis3 Pc (Kennison and Tamkun, 1988) kis4 Pc (Kennison and Tamkun, 1988) kiseAL7 N (Verheyen et al., 1996) kiseB15 N (Verheyen et al., 1996) kiseBA8 N (Verheyen et al., 1996) kiseBD10 N (Verheyen et al., 1996) kisEP563 pnr (Pena-Rangel et al., 2002) Syx1A (van Swinderen and Greenspan, 2005) kisEP2240 pnr (Pena-Rangel et al., 2002) kisk07816 pnr (Pena-Rangel et al., 2002) kisk13416 pnr (Pena-Rangel et al., 2002) Snr1 (Marenda et al., 2004) tna (Gutierrez et al., 2003) kisunspecified Dfd (Gellon et al., 1997) phl (Therrien et al., 2000) Ras85D (Therrien et al., 2000) unspecified Antp (Kennison and Tamkun, 1988) Etl1 (van Swinderen and Greenspan, 2005) ksr (Therrien et al., 2000) MESR4 (van Swinderen and Greenspan, 2005) N (Verheyen et al., 1996, Go and Artavanis-Tsakonas, 1998) pbl (Gregory et al., 2007) Pc (Kennison and Tamkun, 1988, Gellon et al., 1997) ph-PRE (Bloyer et al., 2003) Ret (Read et al., 2005) RpS23 (van Swinderen and Greenspan, 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59444 DroID - A comprehensive database of gene and protein interactions. • FBgn0086902 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33185
Orthologs
OrthoDB Orthologs (115) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69CQT0 Dipteran inclusive ortholog search EOG62BXHK Insect inclusive ortholog search EOG63R2GJ Arthropod inclusive ortholog search EOG6W3R2W Metazoa inclusive ortholog search EOG67Q8ZK
Orthologs in Drosophila Species (EOG69CQT0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\kis     Drosophila melanogaster fruit fly  Dmel\beat-IIIb     Drosophila erecta   Dere\GG24671   Y Drosophila erecta   Dere\GG15403   Y Drosophila yakuba   Dyak\GE18795   Y Drosophila yakuba   Dyak\GE16349   Y Drosophila yakuba   Dyak\GE15960   Y Drosophila yakuba   Dyak\GE20868   Y Drosophila yakuba   Dyak\GE17761   Y Drosophila ananassae   Dana\GF24504   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA22861   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA17619   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11481   Y Drosophila persimilis   Dper\GL25835   Y Drosophila willistoni   Dwil\GK16771   Y Drosophila willistoni   Dwil\GK10478   Y Drosophila willistoni   Dwil\GK22201   Y Drosophila willistoni   Dwil\GK18181   Y Drosophila willistoni   Dwil\GK15212   Y Drosophila willistoni   Dwil\GK23949   Y Drosophila virilis   Dvir\GJ20928   Y Drosophila virilis   Dvir\GJ24251   Y Drosophila virilis   Dvir\GJ18864   Y Drosophila virilis   Dvir\GJ19114   Y Drosophila virilis   Dvir\GJ17250   Y Drosophila grimshawi   Dgri\GH22785   Y Drosophila grimshawi   Dgri\GH10228   Y Drosophila grimshawi   Dgri\GH25288   Y Drosophila grimshawi   Dgri\GH24788   Y Drosophila grimshawi   Dgri\GH24198   Y Drosophila grimshawi   Dgri\GH14857   Y Drosophila grimshawi   Dgri\GH11003   Y Drosophila grimshawi   Dgri\GH12602   Y Drosophila grimshawi   Dgri\GH24147   Y Drosophila grimshawi   Dgri\GH11816   Y
Orthologs in non-Drosophila Dipterans (EOG62BXHK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002230 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007007 Y Anopheles gambiae Malaria mosquito  Agam\AGAP013234 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008482 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006261 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007536 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007177 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005381 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005813 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003506 Y
Orthologs in non-Dipteran Insects (EOG63R2GJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51962 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008052 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008051 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12225 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19348 Y Atta cephalotes Leafcutter ant  Acep\ACEP12489 Y Atta cephalotes Leafcutter ant  Acep\ACEP12493 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22138 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12934 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23073 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11622 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11493 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15285 Y Linepithema humile Argentine ant  Lhum\LH21344 Y Linepithema humile Argentine ant  Lhum\LH24651 Y Linepithema humile Argentine ant  Lhum\LH10887 Y Linepithema humile Argentine ant  Lhum\LH20703 Y Linepithema humile Argentine ant  Lhum\LH16285 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13012 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27294 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13116 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13422 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18266 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20410 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16547 Y Solenopsis invicta Red fire ant  Sinv\SINV24944 Y Solenopsis invicta Red fire ant  Sinv\SINV22026 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005853 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005925 Y Pediculus humanus Human body louse  Phum\PHUM249060 Y Tribolium castaneum Red flour beetle  Tcas\TC014275 Y
Orthologs in non-Insect Arthropods (EOG6W3R2W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Nrgn Y Daphnia pulex Water flea  Dpux\Orai1 Y Daphnia pulex Water flea  Dpux\ndhF Y Daphnia pulex Water flea  Dpux\ACTA Y Ixodes scapularis Deer tick  Isca\ISCW019024 Y Ixodes scapularis Deer tick  Isca\ISCW024821 Y Ixodes scapularis Deer tick  Isca\ISCW024719 Y Ixodes scapularis Deer tick  Isca\ISCW018963 Y Ixodes scapularis Deer tick  Isca\ISCW009853 Y Ixodes scapularis Deer tick  Isca\ISCW021558 Y Ixodes scapularis Deer tick  Isca\ISCW018262 Y
Orthologs in non-Arthropod Metazoa (EOG67Q8ZK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\chd-7 Y Caenorhabditis elegans Nematode  Cele\M03E7.2 Y Caenorhabditis elegans Nematode  Cele\R12E2.7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019459gn Y Danio rerio Zebrafish  Drer\chd7 Y Danio rerio Zebrafish  Drer\chd8 Y Danio rerio Zebrafish  Drer\ENSDARG00000074498 Y Danio rerio Zebrafish  Drer\ENSDARG00000017244 Y Xenopus tropicalis Western clawed frog  Xtro\chd9 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000017194 Y Xenopus tropicalis Western clawed frog  Xtro\chd8 Y Xenopus tropicalis Western clawed frog  Xtro\chd6 Y Gallus gallus Domestic chicken  Ggal\MARCKSL1 Y Gallus gallus Domestic chicken  Ggal\CHD7 Y Gallus gallus Domestic chicken  Ggal\CHD6 Y Gallus gallus Domestic chicken  Ggal\CHD9 Y Mus musculus House mouse  Mmus\Chd9 Y Mus musculus House mouse  Mmus\Chd6 Y Mus musculus House mouse  Mmus\Chd8 Y Rattus norvegicus Norway rat  Rnor\Chd8 Y Rattus norvegicus Norway rat  Rnor\Chd7 Y Rattus norvegicus Norway rat  Rnor\LOC680231 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000016744 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037536 Y Homo sapiens Human  Hsap\ENSG00000100888 Y Homo sapiens Human  Hsap\CHD7 Y Homo sapiens Human  Hsap\CHD6 Y Homo sapiens Human  Hsap\ENSG00000177200 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000100888     Hsap\CHD7     Hsap\CHD6     Hsap\ENSG00000177200
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 54 )
Harvard	- P{XP}kisd04820 - P{XP}kisd05370 - PBac{PB}kisc01706 - PBac{PB}kisc03567 - PBac{RB}kise00780 - PBac{RB}kise04240 - PBac{RB}kise04609 - PBac{WH}kisf05612 - PBac{WH}kisf06548
Kyoto	124060 w1118; P{RS3}kisCB-6339-3
VDRC	v10762 w1118; P{GD4510}v10762 v46685 w1118; P{GD16331}v46685
	More stocks available...
Genomic Clones ( 1 )
	BACR22C14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02209 LD09721
Other clones	IP15878
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02917 GM05208 GM05210 GM05295 LD20141 LP03119 LP12570 LP16363 SD26794
Other clones	45604 214339.1 CK01.18C.G1 CK01.100C.H10 CK02630 Dmel_dig_007144_0602_3505 Dmel_dig_007910_0701_1345 Dmel_neb_012847_0078_2154 Dmel_neb_013676_0442_1463 Dmel_neb_013876_0170_3345 Dmel_neb_013934_0398_0999 Dmel_neb_014287_0452_1109 Dmel_neb_014445_0437_1562 Dmel_neb_014790_0169_3370 Dmel_neb_015414_0677_3366 Dmel_neb_015819_0876_1980 EC31553 EK007047 EK034836 EK049428 EK112550 EK121104 EK121208 EK138444 EK161158 EK163944 EK165241 EK177127 EK178616 EK188644 EK200360 EK201007 EK202251 EK219401 EK228033 EK244033 EK250643 EK264062 EK297327 EK304748 EN07254 EP02959 EP09358 EP09739 EP17930 FGC017B03 FGM235C05 IP14037 IP15778 IP15978 LD25659 LD47873 RH42660 RP004066098 RP004193447 RP004197848 RP004212718 RP004218936 RP004236187 RP004242489 RP004247903 RP004262651 RP004409742 RP004468194 RP004474349 RP004476813 RP004496291 RP004500543 RP004542495 SD05649 UUGC1016
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086902 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33185
Antibody Information
	polyclonal (Daubresse et al., 1999)
Other Information
Discoverer
	Kennison, 1984.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: kis CG3696 (Guan, 1999.11)
Source for database merge of	Source for merge of: kis anon-WO0172774.164 anon-WO0257455.5 (FlyBase, 1996-) Source for merge of: kis BEST:GM02209 (Bayraktaroglu, 2000.11.2) Source for merge of: kis CG3660 CG18326 (FlyBase Genome Annotators, 2002-2003) Source for merge of: kis l(2)k11324 (FlyBase, 1996-) Source for merge of: kis l(2)k13631 l(2)k14112 (BDGP Project Members, 1994-1999) Source for merge of: kis l(2)k16510 (Read et al., 2005)
Additional comments	snoRNA:kis-a is encoded in an intron of kis. (Graveley et al., 2011) mir-965 is located within kis. (Stark et al., 2007) Annotations CG3696, CG3660 and CG18326 merged as CG3696 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of kis anon-WO0172774.164 anon-WO0257455.5 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of kis l(2)k11324 was sequence comparison (date:050921). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells. (Kleino et al., 2005) Loss of zygotic kis function causes homeotic transformations. Loss of maternal kis function causes segmentation defects similar to those caused by mutations in pair-rule genes. (Daubresse et al., 1999) Three EMS-induced alleles have been isolated that weakly suppress the bristle and wing vein phenotypes of NAx-16. (Go and Artavanis-Tsakonas, 1998) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Mutants also interact with Pc. (Gellon et al., 1997) kis is required for the function of other homeotic genes. (Gellon et al., 1995) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) kis is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle. (Kennison and Tamkun, 1988) Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078717 NM_164376 NM_001144289 NM_001258889 NM_001258890 NM_001258891 RefSeq (Proteins) • NP_523441 NP_722617 NP_001137761 NP_001245818 NP_001245819 NP_001245820 DDBJ / EMBL / GenBank • AA390965 AA567240 AAD37500 AAF43004 AAF51527 AAF51530 ACL82968 AF113847 AF215703 AFH03495 AFH03496 AFH03497 AI533719 AQ024954 AQ025961 AQ026108 AQ073293 AQ073424 AQ073555 AQ073613 AQ073679 AW941927 AW942085 AW944430 AX260202 AX482637 AY075355 BH023743 CW848212 CZ467381 CZ468734 CZ472577 CZ472578 CZ474154 CZ474492 CZ476266 CZ478623 CZ479719 CZ481984 CZ482370 CZ482371 CZ488213 CZ489256 Entrez Gene - A searchable database of RefSeq genes. • 33185 UniProtKB/TrEMBL • B7Z002 Q9VPL6 Q9VPL9 Q9Y1L3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) SNF2-related (IPR000330) Chromo domain/shadow (IPR000953) Helicase, C-terminal (IPR001650) BRK domain (IPR006576) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) Chromo domain-like (IPR016197) Chromo domain (IPR023780)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59444 DroID - A comprehensive database of gene and protein interactions. • FBgn0086902 DRSC - Results from RNAi screens. • FBgn0086902 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086902 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086902 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33185 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/kismet1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33185 modMine - Data generated by the modENCODE project. • FBgn0086902
Synonyms & Secondary IDs ( 35 )
Reported As
Symbol Synonym	136/31 (Roch et al., 1998) 2532 (Harvie et al., 1998) 5841 (Harvie et al., 1998) anon-WO0172774.164   anon-WO0257455.5   BEST:GM02209   CG3660 (Eissenberg, 2001, ) CG3696 (Hadar et al., 2012, Grieder et al., 2007, Schneiderman et al., 2009, Berger et al., 2008, Hughes et al., 2008, Schneiderman et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Mast et al., 2011) CG18326   DmelPex20 (Mast et al., 2011) EK2-4 (Therrien et al., 2000) FBtr0078144 (Li et al., 2012) GM02209 (Toba et al., 1999) kis (Edwards et al., 2006, Curtis et al., 2011, Hadar et al., 2012, Gan et al., 2010, Buszczak et al., 2007, Arancio et al., 2010, Lecuyer et al., 2007, Grieder et al., 2007, Ivaldi et al., 2007, Srinivasan et al., 2008, Kankel et al., 2007, Mudiganti et al., 2010, Vázquez et al., 2008, Kucherenko et al., 2008, Petruk et al., 2008, Doheny et al., 2008, Raymond et al., 2004, Font-Burgada et al., 2008, Melicharek et al., 2008, Schneiderman et al., 2009, Paik et al., 2012, Berger et al., 2008, Dubruille et al., 2009, Terriente-Félix et al., 2010, Stark et al., 2007, Bhatia et al., 2010, Di Stefano et al., 2011, Friedman et al., 2011, Terriente-Félix et al., 2011, Wasbrough et al., 2010, Daubresse et al., 1999, Graveley et al., 2011, Karam et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Kis (Ji et al., 2012, Secombe et al., 2007) KIS (Corona et al., 2001, McDaniel et al., 2008, Tie et al., 2012) KIS-L (Srinivasan et al., 2008, Fasulo et al., 2012) kiss (Bejarano and Busturia, 2004) l(2)07812   l(2)k08827   l(2)k11324   l(2)k13631 (BDGP Project Members, 1994-1999) l(2)k14112 (BDGP Project Members, 1994-1999) l(2)k16510 (Spradling et al., 1999, Spradling, 1999.12.9, ) l(2)s3527   l(2)s4771   l(2)s4793   Pex20 (Mast et al., 2011) Su(Pc)21AB   unnamed (Berg and Spradling, 1991)
Name Synonym	kismet (Edwards et al., 2006, Robin et al., 2007, Gellon et al., 1997, Gregory et al., 2007, Secombe et al., 2007, Marenda et al., 2008, Mathieu et al., 2007, Thompson et al., 2008, Srinivasan et al., 2008, Kankel et al., 2007, Singer and Gall, 2011, Doheny et al., 2008, Raymond et al., 2004, Melicharek et al., 2008, Paik et al., 2012, Berger et al., 2008, Dubruille et al., 2009, Terriente-Félix et al., 2010, Melicharek et al., 2010, Schneiderman et al., 2010, Terriente-Félix et al., 2011, Daubresse et al., 1999, Fisher et al., 2008, Davis et al., 2011, Fasulo et al., 2012) Kismet (Armstrong et al., 2007, Schuettengruber et al., 2007, Papp and Muller, 2006, Graves and Tamkun, 2006, Dorighi et al., 2008, Nakayama et al., 2012) lethal (2) k11324   lethal (2) k16510   Peroxin 20 (Mast et al., 2011)
Secondary FlyBase IDs
	FBgn0001309 FBgn0010642 FBgn0010689 FBgn0010697 FBgn0010698 FBgn0021813 FBgn0021918 FBgn0026596 FBgn0031234 FBgn0031236 FBgn0046436 FBgn0063789
References ( 161 )
Generate a list of	All references relating to this gene ( 161 )
List References by type	Research paper  ( 96 ) Supplementary material  ( 10 ) Review  ( 8 ) Personal communication to FlyBase  ( 23 ) Abstract  ( 11 ) FlyBase analysis  ( 4 ) Conference report  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 2 ) Patent  ( 2 )
Recent research papers ( 16 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Fasulo et al., 2012, PLoS Genet. 8(8): e1002878 The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. [FBrf0219217] Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Ji et al., 2012, G3 (Bethesda) 2(12): 1651--1660 In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila. [FBrf0220353] Li et al., 2012, Cell Rep. 1(1): 69--82 Global analysis of RNA secondary structure in two metazoans. [FBrf0219052] Nakayama et al., 2012, Development 139(24): 4582--4590 The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. [FBrf0219981] Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Tie et al., 2012, Mol. Cell. Biol. 32(12): 2323--2334 Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27. [FBrf0218406] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. [FBrf0215017] Singer and Gall, 2011, Nucleus 2(5): 403--409 An inducible nuclear body in the Drosophila germinal vesicle. [FBrf0216533] Terriente-Félix et al., 2011, Dev. Biol. 350(2): 382--392 A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression. [FBrf0212899] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...