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Gene Dmel\sls

General Information
Symbol	Dmel\sls	Species	D. melanogaster
Name	sallimus	Annotation symbol	CG1915
Feature type	protein_coding_gene	FlyBase ID	FBgn0086906
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	Titin, Ket, CG18242, D-titin, l(3)dre8, l(3)rL182, sam, l(3)62Ca, kettin
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	62C2-62C4	Sequence location	3L:2,039,681..2,115,611 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sallimus is referred to in FlyBase by the symbol Dmel\sls (CG1915, FBgn0086906). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding; structural constituent of muscle. There is experimental evidence that it is involved in the biological process: myoblast fusion; mitotic chromosome condensation; locomotion; skeletal muscle tissue development; sarcomere organization; regulation of hemocyte proliferation; muscle attachment; sister chromatid cohesion; mesoderm development. 68 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; organ system; anatomical structure; organelle; cytoplasmic part; non-connected developing system; adult segment; intracellular organelle; eo support cell; nucleus; embryonic procephalic segment; intracellular non-membrane-bounded organelle; organ system subdivision; cell cycle. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold; Protein of unknown function DUF1136; Ribonuclease H-like domain; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval midgut, adult hindgut, adult heart, adult male reproductive system, adult carcass. Gene sequence location is 3L:2039681..2115611.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(3)62Ca Hemizygotes for seventeen of nineteen alleles die during the first larval instar; four of these show some escape into the second instar; two alleles cause lethality in the pupal-adult stage. sls: sallimus (J.A. Kennison) Dominant suppressor of the extra-sex-combs phenotype of heterozygous Pc alleles. Also suppresses the dominant extra-sex-combs phenotype of Pcl alleles.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62C2-62C4   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References 62C-62C   (determined by in situ hybridisation)   (Pokholkova and Zhimulev, 2002) 62C1-62C2   (determined by in situ hybridisation) 62C (determined by in situ hybridisation)   (Zhang et al., 2000) 62C1-62C2     (Machado, 1999.3.16) 62C1-62C1     (Benes, 1999.7.29) 62C1-62C3   (determined by in situ hybridisation)   (Kolmerer et al., 2000) 62C-62C     (Zhang, 1999.4.26) 62C-62C     (Zhang, 1999.4.26) 61C1-61C2     (Machado, 1998.2.2) 62C1-62C2   (determined by in situ hybridisation) 62C3--4 (determined by in situ hybridisation)   (Spradling et al., 1999) 62C-62C   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 62C1-62C2     (Bullard, 1998.5.11) 62C1-62C2   (determined by in situ hybridisation)   (Machado et al., 1998) 62C-62C   (determined by in situ hybridisation)   (Deak et al., 1997) 62C-62C     (Gellon et al., 1997) 62C1-62C2   (determined by in situ hybridisation)   (Machado, 1997.4.17) 62C1-62C3   (determined by in situ hybridisation)   (Machado et al., 1996) 68B8-68F2   (determined by in situ hybridisation)   (Harding et al., 1995) 62C1-62C2   62C3--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Kennison and Tamkun, 1988, Machado et al., 1996)
Left of (cM)	h (Zhang et al., 2000)
Right of (cM)	ru (Zhang et al., 2000)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sls for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sls-RA FBtr0072848  NM_079937   15266   4796 sls-RD FBtr0309042  NM_001259622   17268   4811 sls-RP FBtr0332674  NM_001274375   56489   18468 sls-RQ FBtr0332675  NM_001274376   56405   18440 sls-RR FBtr0332676  NM_001274377   55436   18117 sls-RS FBtr0332677  NM_001274378   47528   15481 sls-RT FBtr0332678  NM_001274379   55136   18017 sls-RU FBtr0332679  NM_001274380   48944   15953 sls-RV FBtr0332680  NM_001274381   49523   16146 sls-RW FBtr0332681  NM_001274382   47519   15478 sls-RX FBtr0332682  NM_001274383   55178   18031 sls-RY FBtr0332683  NM_001274384   32960   10625 sls-RZ FBtr0332684  NM_001274385   46550   15155
Additional Transcript Data & Comments
Reported size (kB)	18.0, 14.5 (northern blot) (Hakeda et al., 2000) 11.5 (northern blot) (Lakey et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sls-PA   FBpp0072727   540.7   4796   5.89     NP_524676   AAF47604 sls-PD   FBpp0301063   542.5   4811   5.88     NP_001246551   AFH04222 sls-PP   FBpp0304920   2102.8   18468   4.66     NP_001261304   AGB93999 sls-PQ   FBpp0304921   2099.5   18440   4.66     NP_001261305   AGB94000 sls-PR   FBpp0304922   2063.4   18117   4.66     NP_001261306   AGB94001 sls-PS   FBpp0304923   1759.9   15481   4.65     NP_001261307   AGB94002 sls-PT   FBpp0304924   2051.1   18017   4.66     NP_001261308   AGB94003 sls-PU   FBpp0304925   1810.7   15953   4.70     NP_001261309   AGB94004 sls-PV   FBpp0304926   1844.1   16146   4.70     NP_001261310   AGB94005 sls-PW   FBpp0304927   1760.3   15478   4.64     NP_001261311   AGB94006 sls-PX   FBpp0304928   2053.6   18031   4.66     NP_001261312   AGB94007 sls-PY   FBpp0304929   1207.3   10625   4.81     NP_001261313   AGB94008 sls-PZ   FBpp0304930   1724.3   15155   4.64     NP_001261314   AGB94009
Additional Polypeptide Data & Comments
Reported size (kDa)	4796 (aa); 540 (kD predicted) (Hakeda et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Protein of unknown function DUF1136 (IPR010939) Immunoglobulin-like fold (IPR013783) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Immunoglobulin I-set (IPR013098) Ribonuclease H-like domain (IPR012337)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140911   AA140912   AA142210   AA567397   AA696212   AA696968   AA697537   AA698266   AA698406   AA699286   AA802415   AA803985   AA941598   AA949978   AE014296 AAF47604   AB026845 BAA90301   AF045775   AF045776 AAC23965   AF045777 AAC23964   AF045778 AAC23963   AF135062 AAF61414   AF135167 AAF62351   AF241648 AAG40155   AF241649 AAF44704   AF241650   AF241651   AE014296 AFH04222   AE014296 AGB93999   AE014296 AGB94000   AE014296 AGB94001   AE014296 AGB94002   AE014296 AGB94003   AE014296 AGB94004   AE014296 AGB94005   AE014296 AGB94006   AE014296 AGB94007   AE014296 AGB94008   AE014296 AGB94009   AI063351   AI063381   AI107689   AI107943   AI113444   AI134977   AI238030   AI238172   AI257291   AI257513   AI257550   AI257730   AI258857   AI259834   AI259889   AI260140   AI260504   AI260962   AI261152   AI293168   AI294011   AI294193   AI294391   AI295519   AI297186   AI387585   AI389637   AI402326   AI404153   AI405798   AI406131   AI516928   AI517017   AI517325   AI531608   AI532745   AI534123   AI534273   AI534592   AI534743   AI534930   AI541852   AI542234   AI542235   AI543088   AI543200   AI543455   AJ012279 CAA09970   AJ012280 CAA09971   AJ238575   AJ238576   AJ238577 CAB43739   AJ245406 CAB76253   AJ271740 CAB93524   AJ400900 CAB96426   AJ400901 CAB96427   AJ400902 CAB96531   AQ025295   AQ026295   AQ026367   AW941248   AW941251   AY075361   AY089650   AY089662   AY094749 AAM11102   BE977632   BG632011   BG632325   BG633144   BG635473   BG636039   BG639316   BH740686   BI167919   BI168019   BI168164   BI170293   BI170847   BI172908   BI214816   BI215283   BI215374   BI227597   BI227635   BI236401   BI237587   BI238254   BI239895   BI363513   BI372395   BI374263   BI482625   BI482661   BI565498   BI565779   BI567733   BI571083   BI572036   BI572114   BI577403   BI577737   BI583498   BI584544   BI585654   BI587999   BI588462   BI589204   BI592160   BI606034   BI611279   BI613115   BI613209   BI613274   BI613581   BI617077   BI623047   BI628351   BI628385   BI628590   BI628593   BI629126   BI632500   BI633327   BI633715   BI635066   BI635340   BI635522   BI635690   BI635718   BI635939   BI637349   BI637631   BI637753   BI638148   BI638154   BI641482   BI641727   BK000146   BT133415   BT133502   CK131504   CK132192   CK135729   CK656963   CK657249   CK657590   CK659243   CK659578   CK659590   CK659681   CK659921   CK660732   CK661116   CK661571   CK661903   CK661941   CK662076   CK662307   CK662482   CO152948   CO153471   CO153526   CO153870   CO154046   CO154126   CO154251   CO154640   CO154642   CO154705   CO154880   CO154925   CO155543   CO155583   CO155672   CO155685   CO156474   CO156813   CO156877   CO157078   CO178959   CO180964   CO181280   CO188167   CO188790   CO189376   CO190213   CO263795   CO264296   CO266307   CO268577   CO268641   CO268645   CO268679   CO268743   CO270000   CO272527   CO274146   CO274617   CO276003   CO279675   CO281270   CO282479   CO286602   CO286681   CO287664   CO288808   CO291042   CO291757   CO295751   CO302498   CO302522   CO305677   CO306559   CO310442   CO312358   CO312958   CO317136   CO317688   CO318307   CO322056   CO322058   CO323368   CO327020   CO328263   CO328741   CO328834   CO329543   CO330953   CO332640   CO334089   CO335567   CO335609   CO336076   CO336208   CO336590   CO337559   CO337826   CO337915   CO337961   CO338185   CO338385   CO338387   CO338436   CO338454   CO338470   CO338543   CO342197   CO342403   CO343683   CO344504   CO345334   CZ468524   CZ469683   CZ475822   CZ480509   CZ485690   CZ488030   CZ488031   EC069255   EC069523   EC071848   EC073277   EC078006   EC080700   EC081969   EC083520   EC090474   EC090502   EC091009   EC201022   EC204296   EC206996   EC208305   EC209442   EC209841   EC213581   EC215816   EC215986   EC216955   EC224560   EC226338   EC228403   EC230268   EC230371   EC236604   EC239771   EC253168   EC257865   EC258514   EL883857   ES691012   ES691013   ES691021   ES691023   ES691062   ES691097   ES691098   ES691099   ES691101   ES691104   ES691109   ES691110   ES696222   ES696223   ES696224   ES696227   ES696309   EV593725   EV598864   EW712639   EW712692   GH291245   GH291251   GH291399   GH951263   GH951565   GH954244   GH957147   GH963575   GH964867   GH966036   GH967418   GH976948   GH980268   GH981913   GH984727   GR705769   GR705842   X72709
UniProtKB/Swiss-Prot	Q9I7U4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435453 3L:2,118,348..2,118,675 evidence=Reporter construct (in vivo) (Junion et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000436381 3L:2,114,681..2,114,995 evidence=Reporter construct (in vivo) (Junion et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000436629 3L:2,089,506..2,089,854 evidence=Reporter construct (in vivo) (Junion et al., 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   pharyngeal muscle   (Machado et al., 1998) embryonic stage 11   mesoderm   (Hakeda et al., 2000) posterior midgut primordium   (Kolmerer et al., 2000) anterior midgut primordium   (Kolmerer et al., 2000) embryonic stage 11 -- 17   embryonic/larval salivary gland   (Kolmerer et al., 2000) visceral mesoderm   (Machado et al., 1998, Hakeda et al., 2000) somatic mesoderm   (Machado et al., 1998, Hakeda et al., 2000, Kolmerer et al., 2000) pharyngeal muscle   (Kolmerer et al., 2000) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 13 -- 17   embryonic/larval somatic muscle   (Machado et al., 1998, Hakeda et al., 2000, Kolmerer et al., 2000) embryonic/larval visceral muscle   (Machado et al., 1998, Hakeda et al., 2000, Kolmerer et al., 2000) embryonic stage 14 -- 17   pharyngeal muscle   (Hakeda et al., 2000) embryonic stage 16   muscle attachment site   (Hakeda et al., 2000) first instar larval stage   embryonic/larval muscle system   (Hakeda et al., 2000)
Additional Descriptive Data
	The 18kb sls transcript is a minor species observed on northern blots. (Hakeda et al., 2000) sls transcripts are first expressed at stage 11 in the mesoderm. They are expressed in most if not all muscles until the third instar larval stage. At stage 14, they are expressed in nearly all somatic, visceral, and pharyngeal muscles. Later they are expressed in muscle attachment sites. (Hakeda et al., 2000) sls transcripts are first detected in early stage 11 embryos. Expression is observed mainly in the hindgut and posterior midgut invagination. By late stage 11, expression is observed throughout the mesoderm and can be seen in the progenitors to the pharyngeal muscles and salivary glands. By stage 12,13, the mesodermal pattern has resolved into a parasegmental pattern. By stage 13,14, expression is present in both somatic and visceral mesoderm. (Kolmerer et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval somatic muscle   (Hakeda et al., 2000) embryonic/larval visceral muscle   (Hakeda et al., 2000) muscle attachment site   (Hakeda et al., 2000) embryonic stage | late   pharyngeal muscle   (Machado et al., 1998) embryonic stage 12 -- 17   myotube   • plasma membrane | restricted (Menon and Chia, 2001) fusion competent cell   • plasma membrane (Menon and Chia, 2001) muscle founder cell   • cytoplasm (Menon and Chia, 2001) embryonic stage 13 -- 17   embryonic/larval somatic muscle   (Machado et al., 1998) embryonic/larval visceral muscle   (Machado et al., 1998) larval stage   muscle cell   • Z disc (Hakeda et al., 2000) pupal stage P6   indirect flight muscle | punctate   (Ayme-Southgate et al., 2004) Comment:30 hr APF pupal stage P7 -- pharate adult stage P8   indirect flight muscle | precursor   • myofibril (Ayme-Southgate et al., 2004) Comment:start at 36 hr APF pharate adult stage P8 -- P15   indirect flight muscle | precursor   • Z disc (Ayme-Southgate et al., 2004) Comment:48 hr APF adult stage   muscle cell   • Z disc (Lakey et al., 1993, Machado et al., 1998, Hakeda et al., 2000) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   indirect flight muscle   (Kolmerer et al., 2000)
Additional Descriptive Data
	sls protein localizes to the nucleus during interphase and to the chromosomes during mitosis. (Lakey et al., 1993, Machado et al., 1998) sls protein can be detected in scattered aggregates dispersed in the cytoplasm of muscle cell precursors as early at 30 hrs APF. By 48 hours sls, along with other myofibrillar proteins, have organized into Z-bands. (Ayme-Southgate et al., 2004) The protein is enriched at the membrane of fusion competent cells and primarily cytoplasmic in founder cells in the developing muscle system. In myotubes sls protein islocated near the points of contact with myoblasts. (Menon and Chia, 2001)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
condensed nuclear chromosome inferred from direct assay (assigned by UniProtKB) (Machado et al., 1998) microtubule associated complex inferred from direct assay (Hughes et al., 2008) sarcomere inferred from direct assay (Hakeda et al., 2000) inferred from direct assay (assigned by UniProtKB) (Machado et al., 1998) Z disc inferred from direct assay (Ayme-Southgate et al., 2004, Hudson et al., 2008) inferred from direct assay (assigned by UniProtKB) (van Straaten et al., 1999) inferred from mutant phenotype (assigned by UniProtKB) (Kolmerer et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval midgut, adult hindgut, adult heart, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult  (59) carcass, 4-day adult  (44) carcass, 20-day adult  (29) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult  (59) carcass, 4-day adult  (44) carcass, 20-day adult  29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    16 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    15 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    12 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    18 carcass, 1-day adult    59 carcass, 4-day adult    44 carcass, 20-day adult    29 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP  (32) pupae 4d postWPP  (34) adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP  32 pupae 4d postWPP  (34) adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    6 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    8 larva L2    10 larva L3 12hr old    19 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    7 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    12 pupae 3d postWPP    32 pupae 4d postWPP    34 adult male 01day    24 adult male 05day    22 adult male 30day    19 adult female 01day    13 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	BDGP expression data • GM05288 GM05521 RH63601 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086906 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sls Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sls62Ca-14 sls62Ca-15 lethal, with Scer\GAL4elav.PLu slsGD9680 lethal, with Scer\GAL4Mef2.PR slsGD9680 lethal | embryonic stage | recessive slsB68 slsB170 slsB173 slsB247 slsC872 slsC995 slsj1D7 slsKet-14 lethal | larval stage sls62Ca-1 sls62Ca-2 sls62Ca-3 sls62Ca-4 sls62Ca-5 sls62Ca-6 sls62Ca-7 sls62Ca-8 sls62Ca-9 sls62Ca-10 sls62Ca-11 sls62Ca-12 sls62Ca-13 sls62Ca-16 sls62Ca-17 sls62Ca-18 sls62Ca-19 lethal | larval stage | recessive sls62Ca-13 slsg72 lethal | recessive sls1 sls62Ca-1 sls62Ca-2 sls62Ca-3 sls62Ca-4 sls62Ca-5 sls62Ca-6 sls62Ca-7 sls62Ca-8 sls62Ca-9 sls62Ca-10 sls62Ca-11 sls62Ca-12 sls62Ca-14 sls62Ca-15 sls62Ca-16 sls62Ca-17 sls62Ca-18 sls62Ca-19 sls110ry- sls04860a slse4 slse82 slsg65 slsj1D7 slsKet-5 slsKet-132 slsrL182 slsS000201 slsS002001 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 slsGD9680 viable sls04860a slsCA06744 slsrL182 Other Phenotypes Allele flightless | dominant slsKet-14 locomotor behavior defective | embryonic stage | recessive slsB68 slsB170 slsB173 slsB247 slsC872 slsC995 slsj1D7 slsS000201 mitotic cell cycle defective sls110ry- slse4 slsg65 slsj1D7 mitotic cell cycle defective (with sls110ry-) slse4 mitotic cell cycle defective (with slse4) sls110ry- slsg65 slsj1D7 mitotic cell cycle defective (with slsg65) slse4 mitotic cell cycle defective (with slsj1D7) slse4 paralytic | larval stage | recessive slsKet-132 visible, with Scer\GAL4pnr-MD237 slsGD9680 visible | pupal stage (with slsg65) slsj1D7 visible | pupal stage (with slsj1D7) slsg65 Phenotype manifest in Allele embryonic/larval hypodermal muscle (with slse4) slsg05 embryonic/larval hypodermal muscle (with slsg05) slse4 embryonic/larval muscle system slse83 slse90 slsg65 slsunspecified embryonic/larval muscle system | third instar larval stage (with slse4) slsg05 embryonic/larval muscle system | third instar larval stage (with slsg05) slse4 embryonic/larval somatic muscle slsC872 slsKet-132 slsKet-14 embryonic labral segment slsC138 embryonic myoblast slsC872 slse90 slsg65 indirect flight muscle slsKet-14 slsKet-5 indirect flight muscle & myofibril slsKet-14 indirect flight muscle & striated muscle thick filament slsKet-14 indirect flight muscle & Z disc slsKet-14 slsKet-5 median tooth | ectopic slsC138 mesothoracic tergum, with Scer\GAL4pnr-MD237 slsGD9680 midgut constriction slse83 slsg65 mitosis & nuclear chromosome sls110ry- slse4 slsg65 slsj1D7 mitosis & nuclear chromosome (with sls110ry-) slse4 mitosis & nuclear chromosome (with slse4) sls110ry- slsg65 slsj1D7 mitosis & nuclear chromosome (with slsg65) slse4 mitosis & nuclear chromosome (with slsj1D7) slse4 mitotic cell cycle sls110ry- slse4 slsg65 slsj1D7 mitotic cell cycle (with sls110ry-) slse4 mitotic cell cycle (with slse4) sls110ry- slsg65 slsj1D7 mitotic cell cycle (with slsg65) slse4 mitotic cell cycle (with slsj1D7) slse4 muscle fiber & nucleus & embryo slsB173 slsB68 slsC872 muscle fiber | embryonic stage slsB170 slsB173 slsB247 slsB68 slsC872 slsC995 slsS000201 slsj1D7 muscle tendon junction | embryonic stage slsKet-14 myofibril slsB173 slsC872 slsj1D7 nucleus slse4 pupal cuticle (with slse4) slsS002001 slsg05 pupal cuticle (with slsg05) slse4 pupal cuticle (with slsS002001) slse4 sarcomere slsB173 slsB68 slsC872 sarcomere | embryonic stage slsKet-14 striated muscle myosin thick filament | embryonic stage slsKet-14 striated muscle thin filament | embryonic stage slsKet-14 trichogen cell, with Scer\GAL4pnr-MD237 slsGD9680 Z disc | embryonic stage slsKet-14
Classical Alleles ( 65 )
For All Classical Alleles Show
Allele of sls Class Mutagen Stocks Known lesion sls1 ethyl methanesulfonate 2 -- slsj1D7 loss of function allele P-element activity 2 Yes slsKG00981 P-element activity 2 -- slsc03242 piggyBac transposase 1 -- slsc05020 piggyBac transposase 1 -- slsd00134 1 -- slsd07587 P-element activity 1 -- slse02736 piggyBac transposase 1 -- slsf03023 1 -- slsf03142 piggyBac transposase 1 -- slsf05452 piggyBac transposase 1 -- slsMI01406 1 -- slsrL182 P-element activity 1 Yes sls04860a P-element activity 0 Yes sls110ry- P-element activity 0 Yes sls136ry+ P-element activity 0 Yes sls136ry- P-element activity 0 Yes sls62Ca-10 ethyl methanesulfonate 0 -- sls62Ca-11 ethyl methanesulfonate 0 -- sls62Ca-12 ethyl methanesulfonate 0 -- sls62Ca-13 ethyl methanesulfonate 0 -- sls62Ca-14 gamma ray 0 -- sls62Ca-15 gamma ray 0 -- sls62Ca-16 gamma ray 0 -- sls62Ca-17 gamma ray 0 -- sls62Ca-18 gamma ray 0 -- sls62Ca-19 gamma ray 0 -- sls62Ca-1 ethyl methanesulfonate 0 -- sls62Ca-2 ethyl methanesulfonate 0 -- sls62Ca-3 ethyl methanesulfonate 0 -- sls62Ca-4 ethyl methanesulfonate 0 -- sls62Ca-5 ethyl methanesulfonate 0 -- sls62Ca-6 ethyl methanesulfonate 0 -- sls62Ca-7 ethyl methanesulfonate 0 -- sls62Ca-8 ethyl methanesulfonate 0 -- sls62Ca-9 ethyl methanesulfonate 0 -- slsB170 ethyl methanesulfonate 0 -- slsB173 ethyl methanesulfonate 0 -- slsB247 ethyl methanesulfonate 0 -- slsB68 ethyl methanesulfonate 0 -- slsC138 ethyl methanesulfonate 0 -- slsC872 ethyl methanesulfonate 0 -- slsC995 ethyl methanesulfonate 0 -- slsCA06744 P-element activity 0 Yes slsDG10710 0 -- slse22 ethyl methanesulfonate 0 -- slse4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- slse80 ethyl methanesulfonate 0 -- slse82 ethyl methanesulfonate 0 -- slse83 ethyl methanesulfonate 0 -- slse90 ethyl methanesulfonate 0 -- slsEP3119 P-element activity 0 Yes slsg05 hypomorphic allele - genetic evidence 0 -- slsg27 gamma ray 0 -- slsg32 gamma ray 0 -- slsG53 P-element activity 0 Yes slsg65 gamma ray 0 -- slsg72 gamma ray 0 -- slsKet-132 hypomorphic allele - genetic evidence P-element activity 0 Yes slsKet-14 loss of function allele Delta2-3 0 Yes slsKet-5 hypomorphic allele - genetic evidence Delta2-3 0 Yes slsS000201 P-element activity 0 Yes slsS002001 hypomorphic allele - genetic evidence Delta2-3 P-element activity 0 -- slsunspecified 0 -- slsZCL2144 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sls Class Mutagen Stocks Known lesion slsGD9680 in vitro construct - RNAi in vitro construct - regulatory fusion 4 Yes slsJF01098 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slsJF01099 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Aprt-1 (Wang et al., 1994) Df(3L)Aprt-3 (Zhang et al., 2000, Wang et al., 1994) Df(3L)Aprt-9 (Wang et al., 1994) Df(3L)Aprt-10 (Wang et al., 1994) Df(3L)Aprt-12 (Wang et al., 1994) Df(3L)Aprt-13 (Wang et al., 1994) Df(3L)Aprt-14 (Zhang et al., 2000, Wang et al., 1994) Df(3L)Aprt-16 (Wang et al., 1994) Df(3L)Aprt-19 (Wang et al., 1994) Df(3L)Aprt-24 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-26 (Wang et al., 1994) Df(3L)Aprt-27 (Wang et al., 1994) Df(3L)Aprt-29 (Wang et al., 1994) Df(3L)Aprt-31 (Wang et al., 1994) Df(3L)Aprt-32 (Spradling et al., 1999, Wang et al., 1994) Df(3L)Aprt-36 (Wang et al., 1994) Df(3L)Aprt-42 (Wang et al., 1994) Df(3L)Aprt-46 (Wang et al., 1994) Df(3L)Aprt-47 (Wang et al., 1994) Df(3L)Aprt-53 (Wang et al., 1994) Df(3L)Aprt-54 (Wang et al., 1994) Df(3L)Aprt-61 (Wang et al., 1994) Df(3L)Aprt-65 (Wang et al., 1994) Df(3L)Aprt-72 (Wang et al., 1994) Df(3L)Aprt-73 (Wang et al., 1994) Df(3L)Aprt-74 (Wang et al., 1994) Df(3L)Aprt-79 (Wang et al., 1994) Df(3L)Aprt-87 (Wang et al., 1994) Df(3L)Aprt-88 (Wang et al., 1994) Df(3L)Aprt-91 (Wang et al., 1994) Df(3L)Aprt-92 (Wang et al., 1994) Df(3L)Aprt-93 (Wang et al., 1994) Df(3L)Aprt-95 (Wang et al., 1994) Df(3L)Aprt-98 (Wang et al., 1994) Df(3L)Aprt-99 (Wang et al., 1994) Df(3L)Aprt-100 (Wang et al., 1994) Df(3L)Aprt-102 (Wang et al., 1994) Df(3L)Aprt-105 (Wang et al., 1994) Df(3L)Aprt-106 (Wang et al., 1994) Df(3L)Aprt-107 (Wang et al., 1994) Df(3L)Aprt-108 (Wang et al., 1994) Df(3L)Aprt-109 (Wang et al., 1994) Df(3L)Aprt-110 (Wang et al., 1994) Df(3L)Aprt-112 (Wang et al., 1994) Df(3L)Aprt-113 (Wang et al., 1994) Df(3L)Aprt-114 (Wang et al., 1994) Df(3L)Aprt-117 (Wang et al., 1994) Df(3L)Aprt-122 (Wang et al., 1994) Df(3L)Aprt-124 (Wang et al., 1994) Df(3L)Aprt-130 (Wang et al., 1994) Df(3L)Aprt-131 (Wang et al., 1994) Df(3L)Aprt-133 (Wang et al., 1994) Df(3L)Aprt-134 (Wang et al., 1994) Df(3L)Aprt-137 (Wang et al., 1994) Df(3L)Aprt-138 (Wang et al., 1994) Df(3L)Aprt-140 (Wang et al., 1994) Df(3L)Aprt-142 (Wang et al., 1994) Df(3L)Aprt-143 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-144 (Wang et al., 1994) Df(3L)Aprt-148 (Wang et al., 1994) Df(3L)Aprt-151 (Wang et al., 1994) Df(3L)Aprt-152 (Wang et al., 1994) Df(3L)Aprt-153 (Wang et al., 1994) Df(3L)Aprt-156 (Wang et al., 1994) Df(3L)Aprt-159 (Wang et al., 1994) Df(3L)Aprt-161 (Wang et al., 1994) Df(3L)Aprt-162 (Wang et al., 1994) Df(3L)Aprt-163 (Wang et al., 1994) Df(3L)Aprt-164 (Wang et al., 1994) Df(3L)Aprt-165 (Wang et al., 1994) Df(3L)Aprt-166 (Wang et al., 1994) Df(3L)Aprt-167 (Wang et al., 1994) Df(3L)Aprt-169 (Wang et al., 1994) Df(3L)Aprt-170 (Wang et al., 1994) Df(3L)Aprt-172 (Wang et al., 1994) Df(3L)Aprt-173 (Wang et al., 1994) Df(3L)Aprt-175 (Wang et al., 1994) Df(3L)Aprt-176 (Wang et al., 1994) Df(3L)Aprt-177 (Wang et al., 1994) Df(3L)Aprt-181 (Wang et al., 1994) Df(3L)Aprt-184 (Wang et al., 1994) Df(3L)Aprt-186 (Wang et al., 1994) Df(3L)Aprt-189 (Wang et al., 1994) Df(3L)Aprt-191 (Wang et al., 1994) Df(3L)Aprt-192 (Wang et al., 1994) Df(3L)Aprt-193 (Wang et al., 1994) Df(3L)Aprt-194 (Wang et al., 1994) Df(3L)Aprt-199 (Zhang et al., 2000, Wang et al., 1994) Df(3L)Aprt-201 (Wang et al., 1994) Df(3L)BSC364 (Christensen et al., 2007.10.29) Df(3L)BSC365 (Christensen et al., 2007.10.29) Df(3L)BSC366 (Christensen et al., 2007.10.29) Df(3L)R-G5 (Szeged Stock Center, 1998-, Spradling et al., 1999, Zhang et al., 2000, BDGP Project Members, 1994-1999) Df(3L)R-G7 (Szeged Stock Center, 1998-, Spradling et al., 1999, BDGP Project Members, 1994-1999, Harding et al., 1995) Ts(2Rt;3Rt)Aprt-185 (Wang et al., 1994)
Not disrupted in	Df(3L)Aprt-15 (Wang et al., 1994) Df(3L)Aprt-18 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-21 (Wang et al., 1994) Df(3L)Aprt-48 (Wang et al., 1994) Df(3L)Aprt-56 (Wang et al., 1994) Df(3L)Aprt-57 (Wang et al., 1994) Df(3L)Aprt-66 (Wang et al., 1994) Df(3L)Aprt-71 (Zhang et al., 2000, Wang et al., 1994) Df(3L)Aprt-77 (Wang et al., 1994) Df(3L)Aprt-84 (Wang et al., 1994) Df(3L)Aprt-89 (Wang et al., 1994) Df(3L)Aprt-90 (Wang et al., 1994) Df(3L)Aprt-94 (Wang et al., 1994) Df(3L)Aprt-96 (Zhang et al., 2000, Wang et al., 1994) Df(3L)Aprt-97 (Wang et al., 1994) Df(3L)Aprt-101 (Wang et al., 1994) Df(3L)Aprt-103 (Wang et al., 1994) Df(3L)Aprt-104 (Wang et al., 1994) Df(3L)Aprt-111 (Wang et al., 1994) Df(3L)Aprt-115 (Wang et al., 1994) Df(3L)Aprt-116 (Wang et al., 1994) Df(3L)Aprt-118 (Wang et al., 1994) Df(3L)Aprt-119 (Wang et al., 1994) Df(3L)Aprt-120 (Wang et al., 1994) Df(3L)Aprt-121 (Wang et al., 1994) Df(3L)Aprt-123 (Zhang et al., 2000, Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-125 (Wang et al., 1994) Df(3L)Aprt-126 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-127 (Wang et al., 1994) Df(3L)Aprt-128 (Wang et al., 1994) Df(3L)Aprt-129 (Wang et al., 1994) Df(3L)Aprt-132 (Wang et al., 1994) Df(3L)Aprt-135 (Wang et al., 1994) Df(3L)Aprt-136 (Wang et al., 1994) Df(3L)Aprt-139 (Wang et al., 1994) Df(3L)Aprt-141 (Wang et al., 1994) Df(3L)Aprt-145 (Wang et al., 1994) Df(3L)Aprt-146 (Wang et al., 1994) Df(3L)Aprt-147 (Wang et al., 1994) Df(3L)Aprt-149 (Wang et al., 1994) Df(3L)Aprt-150 (Wang et al., 1994) Df(3L)Aprt-154 (Wang et al., 1994) Df(3L)Aprt-157 (Wang et al., 1994) Df(3L)Aprt-158 (Wang et al., 1994) Df(3L)Aprt-160 (Wang et al., 1994) Df(3L)Aprt-168 (Wang et al., 1994) Df(3L)Aprt-171 (Wang et al., 1994) Df(3L)Aprt-174 (Wang et al., 1994) Df(3L)Aprt-178 (Wang et al., 1994) Df(3L)Aprt-179 (Wang et al., 1994) Df(3L)Aprt-180 (Wang et al., 1994) Df(3L)Aprt-182 (Wang et al., 1994) Df(3L)Aprt-183 (Wang et al., 1994) Df(3L)Aprt-187 (Wang et al., 1994) Df(3L)Aprt-188 (Wang et al., 1994) Df(3L)Aprt-190 (Wang et al., 1994) Df(3L)Aprt-195 (Wang et al., 1994) Df(3L)Aprt-196 (Wang et al., 1994) Df(3L)Aprt-198 (Zhang et al., 2000, Wang et al., 1994) Df(3L)HR370 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)M21 (BDGP Project Members, 1994-1999)
Duplicated in	Ts(YLt;3Lt)B21 (Hakeda et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{sls-lacZ.CRM1} No P{sls-lacZ.CRM2} No P{sls-lacZ.CRM3} No UAS construct P{GD9680} NA P{TRiP.JF01098} NA P{TRiP.JF01099} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}slsj1D7 No P{lacW}slsS000201 No P{lacW}slsS002001 No P{PZ}sls04860a No P{PZ}slsrL182 No insertion of mobile activating element P{EP}slsEP3119 NA P{XP}slsd00134 NA P{XP}slsd07587 NA miscellaneous insertions Mi{MIC}slsMI01406 NA P{IT1}slsKet-132 NA P{IT1-Δ5}slsKet-5 NA P{PTT-GA}slsCA06744 NA P{PTT-un1}slsG53 NA P{PTT-un1}slsZCL2144 NA P{SUPor-P}slsKG00981 NA P{wHy}slsDG10710 NA PBac{PB}slsc03242 NA PBac{PB}slsc05020 NA PBac{RB}slse02736 NA PBac{WH}slsf03023 NA PBac{WH}slsf03142 NA PBac{WH}slsf05452 NA
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
actin binding inferred from direct assay (assigned by UniProtKB) (van Straaten et al., 1999) inferred from mutant phenotype (assigned by UniProtKB) (Kolmerer et al., 2000) structural constituent of muscle inferred from mutant phenotype (assigned by UniProtKB) (Hakeda et al., 2000)
Biological Process
CV term Evidence References
locomotion inferred from mutant phenotype (assigned by UniProtKB) (Hakeda et al., 2000) mesoderm development inferred from expression pattern (Furlong et al., 2001) mitotic chromosome condensation inferred from mutant phenotype (Machado and Andrew, 2000) muscle attachment inferred from mutant phenotype (assigned by UniProtKB) (Hakeda et al., 2000) myoblast fusion inferred from mutant phenotype (Zhang et al., 2000) regulation of hemocyte proliferation inferred from mutant phenotype (Sinenko et al., 2010) sarcomere organization inferred from genetic interaction with Mlp84B (Clark et al., 2007) inferred from mutant phenotype (assigned by UniProtKB) (Hakeda et al., 2000) sister chromatid cohesion inferred from mutant phenotype (assigned by UniProtKB) (Machado and Andrew, 2000) skeletal muscle tissue development inferred from mutant phenotype (assigned by UniProtKB) (Hakeda et al., 2000, Zhang et al., 2000)
Cellular Component
CV term Evidence References
condensed nuclear chromosome inferred from direct assay (assigned by UniProtKB) (Machado et al., 1998) microtubule associated complex inferred from direct assay (Hughes et al., 2008) sarcomere inferred from direct assay (Hakeda et al., 2000) inferred from direct assay (assigned by UniProtKB) (Machado et al., 1998) Z disc inferred from direct assay (Ayme-Southgate et al., 2004, Hudson et al., 2008) inferred from direct assay (assigned by UniProtKB) (van Straaten et al., 1999) inferred from mutant phenotype (assigned by UniProtKB) (Kolmerer et al., 2000)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
myosin light chain kinase activity inferred from sequence or structural similarity with UniProtKB:Q10466 (FlyBase, 1992-) nucleic acid binding inferred from electronic annotation with InterPro:IPR012337 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
muscle organ development traceable author statement (Dworak and Sink, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sls - Arf51F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - CG10960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - CG13983 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - CG2121 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - CG3009 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - CG32016 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - Cyp4e2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - Or49b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - RASSF8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sls - wun anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sls allele Gene References sls1 E(z) (Bajusz et al., 2001) Pc (Kennison and Tamkun, 1988) slsC138 Dfd (Harding et al., 1995) slsg72 ecd (Henrich et al., 1993) slsunspecified Dfd (Gellon et al., 1997) unspecified ph-p (Fauvarque et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68776 DroID - A comprehensive database of gene and protein interactions. • FBgn0086906 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44013 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9I7U4
Orthologs
OrthoDB Orthologs (251) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Q2F0S Dipteran inclusive ortholog search EOG6V6ZQH Insect inclusive ortholog search EOG6N5TRM, EOG6RN949 Arthropod inclusive ortholog search EOG6MW6MV Metazoa inclusive ortholog search EOG60GRHF
Orthologs in Drosophila Species (EOG6Q2F0S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mst84Db     Drosophila melanogaster fruit fly  Dmel\Ccp84Aa     Drosophila melanogaster fruit fly  Dmel\CG43348     Drosophila melanogaster fruit fly  Dmel\CG15282     Drosophila melanogaster fruit fly  Dmel\Mst87F     Drosophila melanogaster fruit fly  Dmel\CG14742     Drosophila melanogaster fruit fly  Dmel\sls     Drosophila simulans   Dsim\GD13414   Y Drosophila simulans   Dsim\GD13413   Y Drosophila sechellia   Dsec\GM14142   Y Drosophila erecta   Dere\GG14535   Y Drosophila yakuba   Dyak\GE20888   Y Drosophila ananassae   Dana\GF24936   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA15129   Y Drosophila persimilis   Dper\GL24634   Y Drosophila willistoni   Dwil\GK12605   Y Drosophila virilis   Dvir\GJ13444   Y Drosophila mojavensis   Dmoj\GI12167   Y Drosophila grimshawi   Dgri\GH16493   Y
Orthologs in non-Drosophila Dipterans (EOG6V6ZQH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005324 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010022 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007478 Y Anopheles gambiae Malaria mosquito  Agam\CPR5 Y Anopheles gambiae Malaria mosquito  Agam\AGAP013099 Y Anopheles gambiae Malaria mosquito  Agam\AGAP011620 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005376 Y Anopheles gambiae Malaria mosquito  Agam\CPR119 Y Anopheles gambiae Malaria mosquito  Agam\CPR121 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010597 Y Anopheles gambiae Malaria mosquito  Agam\AGAP003486 Y Anopheles gambiae Malaria mosquito  Agam\AGAP009286 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005156 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008567 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000437 Y Anopheles gambiae Malaria mosquito  Agam\CPR2 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005264 Y Anopheles gambiae Malaria mosquito  Agam\AGAP013530 Y Anopheles gambiae Malaria mosquito  Agam\CPR6 Y Anopheles gambiae Malaria mosquito  Agam\Ccp84Ab Y Anopheles gambiae Malaria mosquito  Agam\CPR120 Y Anopheles gambiae Malaria mosquito  Agam\CPR2 Y Anopheles gambiae Malaria mosquito  Agam\CPR117 Y Anopheles gambiae Malaria mosquito  Agam\CPR1 Y Anopheles gambiae Malaria mosquito  Agam\CPR115 Y Anopheles gambiae Malaria mosquito  Agam\CPR119 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005266 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007563 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011765 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012427 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007029 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014141 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012200 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012414 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012435 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018253 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004287 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008315 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012392 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012396 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014770 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012409 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018642 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012400 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012385 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002800 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012447 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012451 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013523 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001517 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012439 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012377 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002801 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008950 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010358 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005383 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012382 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012443 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005040 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012405 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004290 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012431 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012416 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006894 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015243 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018641 Y
Orthologs in non-Dipteran Insects (EOG6N5TRM, EOG6RN949)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43664 Y Apis mellifera Western honey bee  Amel\GB50933 Y Apis mellifera Western honey bee  Amel\GB55599 Y Apis mellifera Western honey bee  Amel\GB43665 Y Apis mellifera Western honey bee  Amel\GB48278 Y Apis mellifera Western honey bee  Amel\Ubx Y Apis mellifera Western honey bee  Amel\GB40241 Y Apis mellifera Western honey bee  Amel\GB47977 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016092 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10867 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13007 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19675 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10894 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23709 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24406 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17353 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23780 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26795 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24163 Y Atta cephalotes Leafcutter ant  Acep\ACEP15051 Y Atta cephalotes Leafcutter ant  Acep\ACEP15062 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12477 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO11251 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14728 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12426 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO25481 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26206 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO25479 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO11962 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12110 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26673 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO24414 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO25577 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO24382 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO11427 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26262 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO25478 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24942 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27059 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10529 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24599 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12192 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24103 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12151 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24059 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10864 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17676 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27388 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27658 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25577 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12195 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10941 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27778 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27303 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11273 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25829 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10702 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28179 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27651 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12004 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25821 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26058 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11096 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28346 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27506 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11530 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10871 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15472 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24193 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11069 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26618 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11306 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11769 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28330 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25121 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24060 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11969 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11137 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24540 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12173 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27637 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26622 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27688 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27879 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27058 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10751 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24964 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25126 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15482 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26924 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19327 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27797 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21942 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20460 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11707 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10725 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27851 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27340 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26160 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26367 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27799 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20777 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24337 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27837 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11221 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10870 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27400 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27270 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10892 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19318 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10510 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26449 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10762 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28475 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27427 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19326 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26509 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24920 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26404 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25568 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27832 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24605 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27560 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24983 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26923 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11242 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11808 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27897 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28183 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28111 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27636 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10789 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11416 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26400 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22447 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26616 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26257 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24087 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24305 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11603 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11075 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26615 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26528 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26056 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11677 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27781 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24511 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11810 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25965 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28255 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11963 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26926 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27608 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26837 Y Linepithema humile Argentine ant  Lhum\LH15999 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15735 Y Solenopsis invicta Red fire ant  Sinv\SINV13501 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI072205 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000622 Y Pediculus humanus Human body louse  Phum\PHUM541090 Y Tribolium castaneum Red flour beetle  Tcas\TC030701 Y
Orthologs in non-Insect Arthropods (EOG6MW6MV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305290 Y Ixodes scapularis Deer tick  Isca\ISCW017764 Y
Orthologs in non-Arthropod Metazoa (EOG60GRHF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F54E2.3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022021gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023142gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Harvard	- P{XP}slsd00134 - P{XP}slsd07587 - PBac{PB}slsc03242 - PBac{PB}slsc05020 - PBac{RB}slse02736 - PBac{WH}slsf03023 - PBac{WH}slsf03142 - PBac{WH}slsf05452
VDRC	v20755 w1118 P{GD9680}v20755 v47298 w1118; P{GD9680}v47298 v47301 w1118; P{GD9680}v47301 v47300 w1118; P{GD9680}v47300/TM3
	More stocks available...
Genomic Clones ( 3 )
	BACR04A21 BACR11G24 BACR16A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 288 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM05288 GM05521 LD28564 RH07382 RH25742
Other clones	MIP34984
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01350 GH03103 GH03155 GH05506 GH05843 GH06559 GH09708 GH12578 GH14012 GH14173 GH16278 GH18146 GH21386 GH23761 GH25930 GH26336 GH27532 GH27637 GH28037 GM08816 GM12455 HL01126 HL02733 HL04073 HL04417 HL08090 LP02153 LP03339 LP03409 LP04393 LP05016 LP05285 LP05607 LP05910 LP05952 LP06184 LP06726 LP07291 LP07513 LP07752 LP09178 LP11433 LP13525 LP16868 LP17435 LP17453 LP17610 LP18060 LP19559 LP20276 LP21169 LP21694 LP21767 LP22030 LP22404 LP22737 LP22842 LP23389 LP24008 RE08421 RE08551 RE08733 RE11690 RE12447 RE15610 RE20945 RE21644 RE21758 RE24691 RE24739 RE32451 RE33836 RE34661 RE36512 RE48340 RE59347 RE61810 RE65339 RE65378 RE71071 RE71462 RH05901 RH07371 RH07451 RH09786 RH17463 RH22126 RH23770 RH28968 RH29693 RH31563 RH38292 RH42193 RH42315 RH42390 RH42765 RH47292 RH55113 RH56721 RH56761 RH57062 RH57068 RH57941 RH63278 RH72114 SD01220 SD02728 SD04346 SD06638 SD07044 SD07502 SD07692 SD07749 SD08394 SD08395 SD09683 SD09891 SD10211 SD12885 SD13621 SD16303 SD16663 SD16891 SD17116 SD17158 SD17481 SD19335 SD19684 SD19822 SD20365 SD20373 SD24831 SD25303 SD26294 SD27390 SD27862
Other clones	8773 12500 12771 31024 39814 70365 77942 99231 101668 146687 161824 166254 174742 177529 214249.24 214311.26 214565.4 272636 273100 277159 283524 bs67b06 CK01.45A.F10 CK01.54B.C7 CK01.60A.H1 CK01.73D.C12 CK01.78B.C8 CK01.98B.E9 CK01.108B.A4 CK01.111A.D3 CK01.112C.C6 CK00340 CK00556 Dmel_neb_003504_0632_3774 Dmel_neb_016209_0950_1879 DMG5-chr3L.4.010.pred.a EC13256 EC13949 EK037941 EK041922 EK044112 EK047322 EK058044 EK063329 EK063544 EK066437 EK069419 EK075919 EK092013 EK092212 EK092220 EK092334 EK092554 EK097106 EK107515 EK113347 EK114641 EK119362 EK135621 EK136446 EK138432 EK146004 EK156332 EK160555 EK184304 EK184335 EK187122 EK187125 EK190327 EK198118 EK211522 EK221646 EK228538 EK230808 EK249230 EK251433 EK267205 EK268810 EK271518 EK291309 EK291506 EK293060 EK296651 EK304125 EK308851 EN00908 EN02032 EN02304 EN03003 EN03353 EN03539 EN03807 EN04520 EN04522 EN04631 EN04955 EN05038 EN06303 EN06355 EN06536 EN06551 EN08131 EN09346 EN09462 EN09906 EN10733 EN10825 EN11755 EN12050 EN12838 EN14810 EN15355 EN15558 EN15658 EN16131 EN16663 EN16703 EN16812 EN16836 EN16858 EN17040 EP05516 EP08840 EP14135 EP14838 EP17825 EP19408 EP21843 GH20861 IP13501 LD25812 LP03833 MB6-CG1915.a RH63601 RP004064437 RP004117763 RP004157461 RP004161894 RP004218006 RP004227197 RP004242714 RP004306129 RP004467554 RP004485148 RP004498449 RP004513381
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086906 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44013
Antibody Information
	polyclonal (Machado et al., 1998, Fabian et al., 2007, Leake et al., 2003)
Other Information
Discoverer
	Kennison, 1984.
Etymology
	'sallimus' is Finnish for 'fate'. (Bullard et al., 2004) Named 'Kettin' after the German word 'Kette', meaning 'chain'. (Lakey et al., 1993)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Titin CG1915 (Zhong, 1999.11)
Source for database merge of	Source for merge of: Ket l(3)rL182 l(3)62Ca (Kolmerer et al., 2000) Source for merge of: Ket Titin (Hakeda et al., 2000) Source for merge of: sls CG18242 (FlyBase Genome Annotators, 2002-2003) Source for merge of: sls CG18857 (Hazelett, 2002.4.8) Source for merge of: sls Ket (Machado and Andrew, 2000) Source for merge of: sls l(3)S002001 (Zhang, 1999.4.26)
Additional comments	FlyBase curator comment: Correspondence with author Sparrow confirmed that 'Salimus' is identical to 'sallimus' (CG1915). (Sparrow and Orfanos, 2008) Annotations CG1915, CG18242 and CG18857 merged as CG1915 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) sls may be involved in the morphogenesis of leg imaginal discs, and it is necessary for condensation and separation of sister chromatids during mitosis. (Pokholkova and Zhimulev, 2002) sls along with bt protein may determine most of the high passive stiffness of the indirect flight muscle that is necessary for stretch activation. (Kulke et al., 2001) sls is essential for the formation and maintenance of normal sarcomere structure of muscles and muscle tendons. (Hakeda et al., 2000) Mutations in sls result in chromosome undercondensation, chromosome breakage, loss of diploidy and premature sister chromatid separation. Mutants also have defects in myoblast fusion and muscle organisation. (Machado and Andrew, 2000) sls has a role in myoblast fusion during myogenesis and later serves to organise myofilaments into the highly ordered arrays underlying skeletal muscle striation. (Zhang et al., 2000) maps to clone: DS07136 (Benes, 1999.7.29) Identification: Via an autoimmune serum from a scleroderma patient. During embryogenesis, sls RNA and protein accumulate in all the somatic and visceral muscles. Antisera made against two different domains of sls localize this portion of the protein to the Z-discs of both larval visceral and adult thoracic muscles by confocal microscopy. (Machado et al., 1998) sls has been cloned and its expression pattern has been analysed. Isolated from a genomic library using human autoimmune scleroderma serum that identifies a chromosomal protein in human cells and Drosophila embryos. (Machado et al., 1998) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype. (Gellon et al., 1997) sls encodes a mitotic chromosomal epitope and is expressed in the somatic musculature during late embryogenesis. (Machado et al., 1997) sls encodes a mitotic chromosomal epitope. (Machado, 1997.4.17) Isolated from a screen of a cDNA expression library with a human CREST serum. (Machado et al., 1996) sls is required for the function of other homeotic genes. (Gellon et al., 1995) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) Mutations of sls interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination. (Harding et al., 1995) Identified as the gene encoding the epitope for a monoclonal antibody, MAC155, that recognises the Z-discs of Drosophila and Lethocerus. The encoded protein may act as scaffolding in the Z-disc. (Lakey et al., 1993) Recessive lethal mutations in this complementation group were identified by failure to complement the recessive lethality of Df(3L)R-R2. (Sliter et al., 1989) sls is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. (Kennison and Tamkun, 1988) Hemizygotes for seventeen of nineteen alleles die during the first larval instar; four of these show some escape into the second instar; two alleles cause lethality in the pupal-adult stage.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079937 NM_001259622 NM_001274375 NM_001274376 NM_001274377 NM_001274378 NM_001274379 NM_001274380 NM_001274381 NM_001274382 NM_001274383 NM_001274384 NM_001274385 RefSeq (Proteins) • NP_524676 NP_001246551 NP_001261304 NP_001261305 NP_001261306 NP_001261307 NP_001261308 NP_001261309 NP_001261310 NP_001261311 NP_001261312 NP_001261313 NP_001261314 DDBJ / EMBL / GenBank • AA140911 AA140912 AA696212 AA802415 AA803985 AA941598 AA949978 AAC23963 AAC23964 AAC23965 AAC23966 AAF44704 AAF47604 AAF61414 AAF62351 AAG22226 AAG40155 AAM11102 AB026845 AF045775 AF045776 AF045777 AF045778 AF135062 AF135167 AF241648 AF241649 AF241650 AF241651 AFH04222 AGB93999 AGB94000 AGB94001 AGB94002 AGB94003 AGB94004 AGB94005 AGB94006 AGB94007 AGB94008 AGB94009 AI260140 AI260962 AI405798 AJ012279 AJ012280 AJ238575 AJ238576 AJ238577 AJ245406 AJ271740 AJ400900 AJ400901 AJ400902 AQ025295 AQ026295 AQ026367 AW941248 AW941251 AY075361 AY094749 BAA90301 BG639316 BH740686 BI565779 BI585654 BK000146 CAA09970 CAA09971 CAB43710 CAB43739 CAB76253 CAB93524 CAB96426 CAB96427 CAB96531 CZ468524 CZ469683 CZ475822 CZ480509 CZ485690 CZ488030 CZ488031 DAA00021 X72709 Entrez Gene - A searchable database of RefSeq genes. • 44013 UniProtKB/Swiss-Prot • Q9I7U4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Protein of unknown function DUF1136 (IPR010939) Immunoglobulin-like fold (IPR013783) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Immunoglobulin I-set (IPR013098) Ribonuclease H-like domain (IPR012337) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM05288 GM05521 RH63601
Linkouts
	BioGRID - A database of protein and genetic interactions • 68776 DroID - A comprehensive database of gene and protein interactions. • FBgn0086906 DRSC - Results from RNAi screens. • FBgn0086906 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086906 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086906 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44013 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44013 modMine - Data generated by the modENCODE project. • FBgn0086906 REDfly - A database of transcriptional regulatory elements. • FBgn0086906 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9I7U4
Synonyms & Secondary IDs ( 39 )
Reported As
Symbol Synonym	0020/01 (Deak et al., 1997) anon-CREST   CG1915 (Vogel et al., 2003, Goldstein and Gunawardena, 2000, Deloger et al., 2009, Quinones-Coello, 2007, Loevenich et al., 2009, Hughes et al., 2008, Ni et al., 2008, Kim et al., 2010, Burkart et al., 2007, Cammarato et al., 2011) CG18242 (Bier and Bodmer, 2004, Montana and Littleton, 2006, Hughes et al., 2008) CG18245   CG18857   CT41299 (Hynes and Zhao, 2000) D-titin (Kulke et al., 2001) D-Titin (Beuchle et al., 2007) d-titin (Hossain et al., 2005) Ket (Junion et al., 2005, Hakeda et al., 2000, van Straaten et al., 1999, Bullard, 1998.5.11, Halaby and Mornon, 1998, Artero et al., 1998, Lakey et al., 1993, Montana and Littleton, 2006) ket (Hakeda et al., 2000) kettin (Texada et al., 2011, Perkins et al., 2010) KZ (Bai et al., 2007) l(3)62Ca (Wang et al., 1994, Lindsley and Zimm, 1992, ) l(3)Ca (Henrich et al., 1993) l(3)dre8 (Kolmerer et al., 2000, Sliter et al., 1989, Lindsley and Zimm, 1992, ) l(3)j1D7 (Spradling et al., 1999, ) l(3)rL182 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(3)S002001 (Szeged Stock Center, 1998-, ) MCP   sal (Artero et al., 2003) sam (Gindhart and Kaufman, 1995, Kennison and Tamkun, 1988, ) sls (Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Buszczak et al., 2007, Quinones-Coello, 2007, Dietzl et al., 2007, Dorus et al., 2006, Xing et al., 2007, Jia and Huan, 2010, Sinenko et al., 2010, Susic-Jung et al., 2012, Vázquez et al., 2008, Bakal et al., 2008, Bai et al., 2008, Petruk et al., 2008, Hudson et al., 2008, Clark et al., 2007, Junion et al., 2007, Loevenich et al., 2009, Lipatov et al., 2005, Leake et al., 2003, Baker et al., 2007, Schnorrer et al., 2010, Kim et al., 2010, Burkart et al., 2007, Wasbrough et al., 2010, Nir et al., 2012, Cingolani et al., 2012) Sls (Deloger et al., 2009, Miller et al., 2008) SLS (Bai et al., 2007, Grzegorczyk and Husmeier, 2012) Titin (Vogel et al., 2003, Hazelett, 2002.4.8, Champagne et al., 2000, Machado, 1998.2.2, Machado, 1997.4.17, Machado et al., 1996, BDGP Project Members, 1994-1999, Machado and Sunkel, 1992, ) titin (Woodcock and Dimitrov, 2001, Padgett and Cho, 1999, Zhang, 1999.4.26, Zhang, 1999.4.26, Zhang, 1999.4.26, Bhanot et al., 1999, Kenny et al., 1999, Pennisi, 1999) unnamed (Vigoreaux, 2001, Machado et al., 1997)
Name Synonym	D-Titin (Chen and Olson, 2004, Taylor, 2003, Dworak and Sink, 2002, Menon and Chia, 2001, Wells, 2000, Machado and Andrew, 1999, Machado and Andrew, 1998, Pokholkova and Zhimulev, 2002, Bradley et al., 2003, Machado and Andrew, 2000, Zhang et al., 2000, Machado et al., 1998, Machado et al., 1998, Menon et al., 2005, Beuchle et al., 2007, Bulchand et al., 2010, Fisher et al., 2008, Elhanany-Tamir et al., 2012, Labeau-Dimenna et al., 2012) Dtitin (Taylor, 2002) D-titin (Clark et al., 2007, Clark et al., 2007, Fabian et al., 2007) D-titin-KZ (Jani and Schock, 2007) Kettin (Jacinto and Baum, 2003, Champagne et al., 2000, Montana and Littleton, 2006, Katzemich et al., 2012, Langer et al., 2010, Beuchle et al., 2007, Susic-Jung et al., 2012, Hudson et al., 2008, Leake et al., 2003, Clark et al., 2007, Bulchand et al., 2010) kettin (Roper et al., 2002, Morin et al., 2001, Dove, 2001, Furlong et al., 2001, Kulke et al., 2001, Labeit, 1993.3.18, Kulke et al., 2001, Kenny et al., 1999, Southgate et al., 2007, Burkart et al., 2007, Ayme-Southgate et al., 2004, Carrasco-Rando and Ruiz-Gómez, 2008, Fabian et al., 2007, Texada et al., 2011) lethal(3)62Ca   lethal (3) S002001   Mitotic Chromosomal Protein   Salimus (Sparrow and Orfanos, 2008) salimus (Labeau-Dimenna et al., 2012) sallimus (Gellon et al., 1997, Burkart et al., 2007, Clark and Beckerle, 2008, Xing et al., 2007, Susic-Jung et al., 2012, Bai et al., 2008, Hudson et al., 2008, Clark et al., 2007, Fabian et al., 2007, Harbison et al., 2005, Cammarato et al., 2011, Sinenko et al., 2010) Sallimus (Cho et al., 2005, Bai et al., 2007, Miller et al., 2008, Elhanany-Tamir et al., 2012) Titin (Griemert et al., 2007, Harris and Beckendorf, 2007, Kim et al., 2007, Dialynas et al., 2010, Elhanany-Tamir et al., 2012, Chechenova et al., 2013) titin (Jani and Schock, 2007, Fabian et al., 2007, Banyai and Patthy, 2004, Leake et al., 2003)
Secondary FlyBase IDs
	FBgn0002186 FBgn0003432 FBgn0010396 FBgn0010850 FBgn0011512 FBgn0015898 FBgn0020409 FBgn0024279 FBgn0028238 FBgn0035301 FBgn0035302 FBgn0042183
References ( 176 )
Generate a list of	All references relating to this gene ( 176 )
List References by type	Research paper  ( 97 ) Supplementary material  ( 11 ) Review  ( 15 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 16 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 9 ) Book  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 10 )
	Chechenova et al., 2013, J. Biol. Chem. 288(6): 3718--3726 The Drosophila Z-disc Protein Z(210) Is an Adult Muscle Isoform of Zasp52, Which Is Required for Normal Myofibril Organization in Indirect Flight Muscles. [FBrf0220782] Cingolani et al., 2012, Front. Genet. 3: 35 Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. [FBrf0217795] Elhanany-Tamir et al., 2012, J. Cell Biol. 198(5): 833--846 Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules. [FBrf0219334] Grzegorczyk and Husmeier, 2012, Stat. Appl. Genet. Mol. Biol. 11(4): A non-homogeneous dynamic bayesian network with sequentially coupled interaction parameters for applications in systems and synthetic biology. [FBrf0219097] Jumbo-Lucioni et al., 2012, BMC Genomics 13: 659 Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. [FBrf0220442] Katzemich et al., 2012, J. Cell Sci. 125(14): 3367--3379 The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila. [FBrf0219368] Labeau-Dimenna et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(44): 17983--17988 Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila. [FBrf0219862] Nir et al., 2012, PLoS Genet. 8(3): e1002632 Phosphorylation of the Drosophila melanogaster RNA-Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity. [FBrf0217996] Susic-Jung et al., 2012, Dev. Biol. 370(1): 86--97 Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. [FBrf0219326] Texada et al., 2011, Exp. Cell Res. 317(4): 474--487 Tropomyosin is an interaction partner of the Drosophila coiled coil protein Yuri Gagarin. [FBrf0212786] Show all research papers ...
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	All reviews listed in FlyBase were published before 2011 Show reviews ...