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Gene Dmel\egg

General Information
Symbol	Dmel\egg	Species	D. melanogaster
Name	eggless	Annotation symbol	CG12196
Feature type	protein_coding_gene	FlyBase ID	FBgn0086908
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	dSETDB1, CG30426, DmSetdb1, CG30422, SetDB1, dEset
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60E1-60E1	Sequence location	2R:20,663,057..20,667,437 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eggless is referred to in FlyBase by the symbol Dmel\egg (CG12196, FBgn0086908). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; histone methyltransferase activity (H3-K9 specific); double-stranded methylated DNA binding. There is experimental evidence that it is involved in the biological process: wing disc development; histone methylation; regulation of gene expression, epigenetic; histone H3-K9 methylation; DNA hypermethylation; instar larval or pupal development; negative regulation of gene expression, epigenetic; oogenesis; female germ-line stem cell division; negative regulation of transcription, DNA-dependent. 28 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; organelle; external compound sense organ; adult segment; portion of tissue; intracellular non-membrane-bounded organelle; intracellular organelle; intracellular organelle part; imaginal precursor. It has one annotated transcript and one annotated polypeptide. Protein features are: Methyl-CpG DNA binding; Post-SET domain; Pre-SET domain; SET domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Gene sequence location is 2R:20663057..20667437.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{UAS-egg.T}
FB2012_01	References Chiolo et al., 2011, Cell 144(5): 732--744 Sequence features BKN22913 HFA04119 BKN24543
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60E1-60E1   Limits computationally determined from genome sequence between P{lacW}Mmp1k04809 and P{EP}Reg-5EP1065
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\egg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) egg-RA FBtr0112777  NM_138122   3950   1262
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein egg-PA   FBpp0111689   141.9   1262   5.16     NP_611966   AAF47268
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pre-SET domain (IPR007728) SET domain (IPR001214) Post-SET domain (IPR003616) Methyl-CpG DNA binding (IPR001739)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264251   AA390510   AA951219   AE013599 AAF47268   AY051799 AAK93223   BF499338   BI638748   BT001309 AAN71064   BT023947   BT024273   CO277559   CO285620   CO301054   CO304977   CO326412   CO327193   CO343096   EC057647   EC074632   EC077190   EC201312   EC211349   EC232297   EC259131   EC259861   EL874424   EV584102   GH746201   GH746508   GH762245   GH764171   GH765687
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086908    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086908 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086908 expression level Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3665) embryo 02-04hr  (5726) embryo 04-06hr  (4954) embryo 06-08hr  (2793) embryo 08-10hr  (2330) embryo 10-12hr  (1518) embryo 12-14hr  (1252) embryo 14-16hr  (1579) embryo 16-18hr  (1216) embryo 18-20hr  (678) embryo 20-22hr  (2171) embryo 22-24hr  (1667) larva L1  (633) larva L2  (558) larva L3 12hr old  (525) larva L3 puffstage 1-2  (603) larva L3 puffstage 3-6  (864) larva L3 puffstage 7-9  (899) white prepupae new  (908) white prepupae 12hr  (1242) white prepupae 24hr  (1396) pupae 2d postWPP  (732) pupae 3d postWPP  (418) pupae 4d postWPP  (326) adult male 01day  (440) adult male 05day  (535) adult male 30day  (535) adult female 01day  (1087) adult female 05day  (1808) adult female 30day  (1881) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3665) embryo 02-04hr  (5726) embryo 04-06hr  (4954) embryo 06-08hr  (2793) embryo 08-10hr  (2330) embryo 10-12hr  (1518) embryo 12-14hr    1252 embryo 14-16hr  (1579) embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr  (2171) embryo 22-24hr  (1667) larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day  (1808) adult female 30day  (1881) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086908 expression level Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3665) embryo 02-04hr  (5726) embryo 04-06hr  (4954) embryo 06-08hr  (2793) embryo 08-10hr  (2330) embryo 10-12hr  (1518) embryo 12-14hr  (1252) embryo 14-16hr  (1579) embryo 16-18hr  (1216) embryo 18-20hr  (678) embryo 20-22hr  (2171) embryo 22-24hr  (1667) larva L1  (633) larva L2  (558) larva L3 12hr old  (525) larva L3 puffstage 1-2  (603) larva L3 puffstage 3-6  (864) larva L3 puffstage 7-9  (899) white prepupae new  (908) white prepupae 12hr  (1242) white prepupae 24hr  (1396) pupae 2d postWPP  (732) pupae 3d postWPP  (418) pupae 4d postWPP  (326) adult male 01day  (440) adult male 05day  (535) adult male 30day  (535) adult female 01day  (1087) adult female 05day  (1808) adult female 30day  (1881) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3665) embryo 02-04hr  (5726) embryo 04-06hr  (4954) embryo 06-08hr  (2793) embryo 08-10hr  2330 embryo 10-12hr  1518 embryo 12-14hr    1252 embryo 14-16hr  1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr  2171 embryo 22-24hr  1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day  1808 adult female 30day  1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3665 embryo 02-04hr    5726 embryo 04-06hr    4954 embryo 06-08hr    2793 embryo 08-10hr    2330 embryo 10-12hr    1518 embryo 12-14hr    1252 embryo 14-16hr    1579 embryo 16-18hr    1216 embryo 18-20hr    678 embryo 20-22hr    2171 embryo 22-24hr    1667 larva L1    633 larva L2    558 larva L3 12hr old    525 larva L3 puffstage 1-2    603 larva L3 puffstage 3-6    864 larva L3 puffstage 7-9    899 white prepupae new    908 white prepupae 12hr    1242 white prepupae 24hr    1396 pupae 2d postWPP    732 pupae 3d postWPP    418 pupae 4d postWPP    326 adult male 01day    440 adult male 05day    535 adult male 30day    535 adult female 01day    1087 adult female 05day    1808 adult female 30day    1881 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086908    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086908 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086908 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30426-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for egg Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)Dll-MP) egg1473 lethal | male (with Df(2R)Dll-MP) egg235 lethal | partially, with Scer\GAL4Act5C.PU eggdsRNA.hp.Scer\UAS lethal | P-stage, with Scer\GAL4da.G32 egg421-1261.Scer\UAS.P\T lethal | pupal stage, with Scer\GAL4c698a eggdsRNA.Scer\UAS lethal | pupal stage | recessive egg10.1a lethal | recessive egg1473 semi-lethal (with Df(2R)ED4071) eggGS7132 semi-lethal (with eggGS7132) eggnull semi-lethal (with eggnull) eggGS7132 semi-lethal | recessive eggGS7132 eggnull viable egg3HA viable, with Scer\GAL4pnr-MD237 eggGD10078 eggGD10080 Sterility Allele female sterile eggunspecified female sterile (with Df(2R)Dll-MP) egg235 egg1473 female sterile | germline clone | recessive egg1473 fertile egg3HA sterile eggG19561 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 eggGD10080 developmental rate defective | larval stage, with Scer\GAL4da.G32 eggdsRNA.Scer\UAS increased cell death (with Df(2R)Dll-MP) egg1473 locomotor behavior defective eggunspecified locomotor behavior defective | larval stage, with Scer\GAL4Act5C.PU eggdsRNA.hp.Scer\UAS non-suppressor of variegation, with P{RS5}5-HA-1005 egg1430 non-suppressor of variegation | dominant, with In(1)wm4 egg1473 non-suppressor of variegation | dominant, with P{RS3}panCB-5204-3 egg1473 non-suppressor of variegation | dominant, with P{RS5}5-HA-1902 egg1473 non-suppressor of variegation | dominant, with P{RS5}5-HA-1992 egg1473 non-suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3 egg1473 short lived, with Scer\GAL4Act5C.PU eggdsRNA.hp.Scer\UAS suppressor of variegation egg10.1a suppressor of variegation, with P{hsp26-pt-T}118E-10 egg1430 suppressor of variegation | recessive egg10.1a visible, with Scer\GAL4lz-gal4 eggdsRNA.Scer\UAS visible, with Scer\GAL4pnr-MD237 eggGD10080 Phenotype manifest in Allele chromocenter, with Scer\GAL4da.G32 egg421-1261.Scer\UAS.P\T egg, with Scer\GAL4nos.PG eggdsRNA.hp.Scer\UAS egg chamber (with Df(2R)Dll-MP) egg1473 egg chamber | germline clone egg1473 eye disc posterior to the morphogenetic furrow, with Scer\GAL4lz-gal4 eggdsRNA.Scer\UAS follicle cell (with Df(2R)Dll-MP) egg1473 germarium (with Df(2R)Dll-MP) egg1473 germline cyst (with Df(2R)Dll-MP) egg1473 interommatidial bristle eggGS7132 interommatidial bristle, with Scer\GAL4lz-gal4 eggdsRNA.Scer\UAS mesothoracic tergum, with Scer\GAL4pnr-MD237 eggGD10080 ommatidium, with Scer\GAL4lz-gal4 eggdsRNA.Scer\UAS ovary eggG19561 ovary (with Df(2R)Dll-MP) egg1473 ovary (with Df(2R)ED4065) eggG19561 polytene chromosome, with Scer\GAL4da.G32 egg421-1261.Scer\UAS.P\T wing eggGS7132 eggnull eggunspecified wing, with Scer\GAL4Act5C.PU eggdsRNA.hp.Scer\UAS wing, with Scer\GAL4ap-md544 eggdsRNA.Scer\UAS wing (with eggGS7132) eggnull wing (with eggnull) eggGS7132
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of egg Class Mutagen Stocks Known lesion egg1473 ethyl methanesulfonate 1 Yes egg235 ethyl methanesulfonate 1 Yes eggGS7132 hypomorphic allele - molecular evidence 1 Yes eggKG05872 P-element activity 1 -- eggMB00702 1 -- egg10.1a amorphic allele - genetic evidence recombination 0 Yes egg1430 0 -- egg3HA recombination 0 Yes eggG19561 0 Yes eggnull FLPase 0 Yes eggunspecified 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of egg Class Mutagen Stocks Known lesion eggGD10078 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eggGD10080 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eggdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes eggHMS00112 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eggHMS00443 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eggJF01310 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eggKK105407 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes egg+t9 in vitro construct - genomic fragment 0 Yes egg421-1261.Scer\UAS.P\T.T:Ivir\HA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes egg421-1261.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes eggdsRNA.hp.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes eggH1195K.Scer\UAS.P\T.T:Ivir\HA in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes eggH1195K.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes eggKK102817 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes eggScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes eggScer\UAS.P\T.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eggScer\UAS.Δset.T:Disc\RFP-DsRed2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Dll-MP (Clough et al., 2007) Df(2R)ED4065 (Seum et al., 2007) Df(2R)ED4071 (Tzeng et al., 2007, Tzeng et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10078} NA P{GD10080} NA P{KK102817} NA P{KK105407} NA P{TRiP.HMS00112} NA P{TRiP.HMS00443} NA P{TRiP.JF01310} NA P{UAS-dSETDB1.hp} NA P{UAS-egg.T} NA P{UAS-egg-dsRed2} NA P{UAS-Eset.IR} NA P{UASp-egg.421-1261} NA P{UASp-egg.H1195K} NA P{UASp-egg.HA.421-1261} NA P{UASp-egg.HA.H1195K} NA P{UASp-egg.RFP} NA characterization construct P{GC64N} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}eggKG05872 NA insertion of enhancer trap binary system Mi{ET1}eggMB00702 No insertion of mobile activating element P{GSV2}eggGS7132 NA P+PBac{XP5.WH5}eggnull NA
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
double-stranded methylated DNA binding inferred from direct assay (Gou et al., 2010) histone methyltransferase activity (H3-K9 specific) inferred from direct assay (Gou et al., 2010, Tzeng et al., 2007) inferred from mutant phenotype (Clough et al., 2006, Clough et al., 2007, Seum et al., 2007) protein binding inferred from physical interaction with Ca-P60A (Stabell et al., 2006) inferred from physical interaction with CG14820 (Stabell et al., 2006) inferred from physical interaction with CG32626 (Stabell et al., 2006) inferred from physical interaction with ctp (Stabell et al., 2006) inferred from physical interaction with Mcr (Stabell et al., 2006) inferred from physical interaction with Pof (Tzeng et al., 2007) inferred from physical interaction with spir (Stabell et al., 2006) inferred from physical interaction with UbcD10 (Stabell et al., 2006) inferred from physical interaction with usp (Stabell et al., 2006) inferred from physical interaction with Zasp52 (Stabell et al., 2006)
Biological Process
CV term Evidence References
DNA hypermethylation inferred from mutant phenotype (Gou et al., 2010) female germ-line stem cell division inferred from direct assay (Yoon et al., 2008) histone H3-K9 methylation inferred from direct assay (Tzeng et al., 2007) inferred from mutant phenotype (Clough et al., 2007, Seum et al., 2007) histone methylation inferred from mutant phenotype (Clough et al., 2006) instar larval or pupal development inferred from mutant phenotype (Stabell et al., 2006) negative regulation of gene expression, epigenetic inferred from direct assay (Gou et al., 2010) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Gou et al., 2010) oogenesis inferred from direct assay (Yoon et al., 2008) inferred from mutant phenotype (Clough et al., 2006, Clough et al., 2007) regulation of gene expression, epigenetic inferred from mutant phenotype (Tzeng et al., 2007) wing disc development inferred from mutant phenotype (Stabell et al., 2006)
Cellular Component
CV term Evidence References
colocalizes_with chromocenter inferred from direct assay (Seum et al., 2007) cytoplasm inferred from direct assay (Clough et al., 2007) nucleus inferred from direct assay (Clough et al., 2007, Koch et al., 2009) polytene chromosome inferred from direct assay (Stabell et al., 2006, Seum et al., 2007)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007728 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions egg allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63532 DroID - A comprehensive database of gene and protein interactions. • FBgn0086908 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37962
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA15835
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004290-PA Aedes aegypti (mosquito) AGAP007978-PA Anopheles gambiae (mosquito) XP_392624.3 Apis mellifera (honey bee) XP_001952618.1 Acyrthosiphon pisum (pea aphid) 125839 Branchiostoma floridae (lancelet) XP_001895454.1 Brugia malayi (roundworm nematode) ENSBTAP00000009641 Bos taurus (bovine) CN20718 Caenorhabditis brenneri (small nematode) CBP26723 Caenorhabditis briggsae (nematode) CE42016 Caenorhabditis elegans (worm) ENSCAFP00000031500 Canis familiaris (dog) CPIJ016652 Culex pipens (mosquito) ENSCPOP00000001472 Cavia porcellus (guinea pig) 224568 Capitella spl (polychaete worm) 304216 Daphnia pulex (daphnia) ENSDARP00000082796 Danio rerio (zebra fish) ENSECAP00000021483 Equus caballus (horse) ENSGACP00000015449 Gymnopilus aculeatus (mushroom) ENSP00000357965 Homo sapiens (human) ISCW001711-PA Ixodes scapularis (deer tick) 111681 Lottia gigantea (owl limpet) ENSMODP00000023474 Monodelphis domestica (gray opossum) ENSMUSP00000015841 Mus musculus (house mouse) XP_001603698.1 Nasonia vitripennis (wasp) ENSORLP00000013295 Oryzias latipes (japanese killifish) LOC_Os08g30910.1 Oryza sativa (asian rice) PHUM001943-PA Pediculus humanus (human body louse) ENSPPYP00000001036 Pongo pygmaeus (orangutan) 243333 Populus trichocarpa (black cottonwood) ENSPTRP00000051798 Pan troglodytes (chimpanzee) ENSRNOP00000028709 Rattus norvegicus (norway rat) Smp_150850.2 Schistosoma mansoni (trematode parasite) 61660 Trichoplax adhaerens (metazoa) XP_969790.2 Tribolium castaneum (red flour beetle) ENSTNIP00000010889 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037410 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019584 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10069 LH15981 ISCW005550 ISCW001711 FBgn0229227 FBgn0223644 FBgn0208216 FBgn0196235 FBgn0166737 JGI_V11_303556 JGI_V11_304216 FBgn0246264 FBgn0155302 FBgn0142251 FBgn0129002 FBgn0112094 FBgn0088586 CPIJ016652 BGIBMGA011407 ACYPI22783 ACYPI009716 ACYPI006306 ACYPI006182 ACYPI003919 GB17661 AGAP007978 AAEL004290 PB21545 PHUM415050 GLEAN_06043
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	24106 y1 w1118; P{UAS-Eset.IR}48 30566 w*; bw1 egg235/SM1 31352 y1 v1; P{TRiP.JF01310}attP2 30565 w*; bw1 egg1473/SM1 14129 y1 w67c23; P{SUPor-P}eggKG05872 22876 y1 w67c23; Mi{ET1}eggMB00702/CyO
Kyoto	201031 y1 w67c23; P{GSV2}eggGS7132/SM1
VDRC	v101677 P{KK105407}VIE-260B v21172 w1118; P{GD10080}v21172 v21173 w1118; P{GD10080}v21173 v33729 w1118; P{GD10078}v33729 v33730 w1118; P{GD10078}v33730
	More stocks available...
Genomic Clones ( 1 )
	BACR27P17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13877 IP14531 IP14732 LD31569
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD09692 SD21118
Other clones	7594 54720 63965 74421 124203 214275.78 214539.70 CK01.37D.F4 Dmel_dig_009583_0593_1687 EK125460 EK169702 EK179957 EK246833 EP03853 EP06432 EP16108 IP14432 RP001012599 RP001029522 RP001038108 RP001051760 RP001052977
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086908 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37962 246607
Antibody Information
	monoclonal (Gou et al., 2010) polyclonal (Chiolo et al., 2011, Yoon et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: egg CG30422 CG30426 (Hazelrigg, 2006.3.6) Source for identity of: egg CG30426 (FlyBase Genome Annotators, 2007) Source for identity of: egg Dmsetdb1 (Seum, 2007.2.26)
Source for database merge of	Source for merge of: CG30422 CG30426 (Hazelrigg, 2006.3.6) Source for merge of: CG30426 BcDNA:AT13877 (FlyBase, 1996-)
Additional comments	Annotations CG30422 and CG30426 merged as CG12196 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) FlyBase curator comment: Correspondence with author Lee revealed that 'dSETDB1' corresponds to 'egg'. (Lee et al., 2007) Source for merge of CG30426 BcDNA:AT13877 was shared cDNA (AT13877) (date:030602). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
Other Comments
	egg is required in the ovary for trimethylation of His3 at its K9 residue. (Clough et al., 2007) egg is required for for the proliferation and viability of somatic cells in the germarium of the ovary. egg is also required for the viability of germ cells in the ovary. (Clough et al., 2007) Identification: In a genetic screen for EMS-induced lethal and female sterile mutations uncovered by Df(2R)Dll-MP. (Clough et al., 2006) egg mediates trimethylation of histone H3 at lysine 9 in ovary germ cells. (Clough et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138122 RefSeq (Proteins) • NP_611966 DDBJ / EMBL / GenBank • AA264251 AA951219 AAF47268 AAK93223 AAN71064 AY051799 BF499338 BT001309 Entrez Gene - A searchable database of RefSeq genes. • 37962
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pre-SET domain (IPR007728) SET domain (IPR001214) Post-SET domain (IPR003616) Methyl-CpG DNA binding (IPR001739)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63532 DroID - A comprehensive database of gene and protein interactions. • FBgn0086908 DRSC - Results from RNAi screens. • FBgn0086908 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086908 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30426-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086908 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37962 246607 InParanoid A subset of ortholog calls from InParanoid. • AAEL004290-PA Aedes aegypti (mosquito) AGAP007978-PA Anopheles gambiae (mosquito) XP_392624.3 Apis mellifera (honey bee) XP_001952618.1 Acyrthosiphon pisum (pea aphid) 125839 Branchiostoma floridae (lancelet) XP_001895454.1 Brugia malayi (roundworm nematode) ENSBTAP00000009641 Bos taurus (bovine) CN20718 Caenorhabditis brenneri (small nematode) CBP26723 Caenorhabditis briggsae (nematode) CE42016 Caenorhabditis elegans (worm) ENSCAFP00000031500 Canis familiaris (dog) CPIJ016652 Culex pipens (mosquito) ENSCPOP00000001472 Cavia porcellus (guinea pig) 224568 Capitella spl (polychaete worm) 304216 Daphnia pulex (daphnia) ENSDARP00000082796 Danio rerio (zebra fish) ENSECAP00000021483 Equus caballus (horse) ENSGACP00000015449 Gymnopilus aculeatus (mushroom) ENSP00000357965 Homo sapiens (human) ISCW001711-PA Ixodes scapularis (deer tick) 111681 Lottia gigantea (owl limpet) ENSMODP00000023474 Monodelphis domestica (gray opossum) ENSMUSP00000015841 Mus musculus (house mouse) XP_001603698.1 Nasonia vitripennis (wasp) ENSORLP00000013295 Oryzias latipes (japanese killifish) LOC_Os08g30910.1 Oryza sativa (asian rice) PHUM001943-PA Pediculus humanus (human body louse) ENSPPYP00000001036 Pongo pygmaeus (orangutan) 243333 Populus trichocarpa (black cottonwood) ENSPTRP00000051798 Pan troglodytes (chimpanzee) ENSRNOP00000028709 Rattus norvegicus (norway rat) Smp_150850.2 Schistosoma mansoni (trematode parasite) 61660 Trichoplax adhaerens (metazoa) XP_969790.2 Tribolium castaneum (red flour beetle) ENSTNIP00000010889 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037410 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019584 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/eggless.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37962 modMine - Data generated by the modENCODE project. • FBgn0086908 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10069 LH15981 ISCW005550 ISCW001711 FBgn0229227 FBgn0223644 FBgn0208216 FBgn0196235 FBgn0166737 JGI_V11_303556 JGI_V11_304216 FBgn0246264 FBgn0155302 FBgn0142251 FBgn0129002 FBgn0112094 FBgn0088586 CPIJ016652 BGIBMGA011407 ACYPI22783 ACYPI009716 ACYPI006306 ACYPI006182 ACYPI003919 GB17661 AGAP007978 AAEL004290 PB21545 PHUM415050 GLEAN_06043
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	AAF47268 Dm (Alvarez-Venegas and Avramova, 2002) AAM70794 (Hendrich and Tweedie, 2003) BcDNA:AT13877   CG12196 (FlyBase Genome Annotators, 2007, Tzeng et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) CG30422 (Seum, 2007.2.26, Clough et al., 2007, Tzeng et al., 2007, Seum et al., 2007) CG30426 (Koh et al., 2007, Schotta et al., 2004, FlyBase, 1996-, Seum, 2007.2.26, Clough et al., 2007, Mis et al., 2006, Tzeng et al., 2007, Seum et al., 2007) dEset (Stabell et al., 2006, Hines et al., 2009) DmSetdb1 (Seum et al., 2007, Seum et al., 2007, Huang et al., 2008) Dm-setdb1 (Seum et al., 2007) Dmsetdb1 (Seum, 2007.2.26) dSETDB1 (Lee et al., 2007, Mis et al., 2006, Tzeng et al., 2007, Brower-Toland et al., 2009, Hines et al., 2009, Koch et al., 2009, Gou et al., 2010, Yoon et al., 2008, Tzeng et al., 2007) dsetdb1 (Yoon et al., 2008) dSetdb1 (Cryderman et al., 2011) egg (Clough and Hazelrigg, 2007, Clough et al., 2007, Nurminsky, 2007, Gan et al., 2010, Koryakov et al., 2011, Brower-Toland et al., 2009, Hines et al., 2009, Koch et al., 2009, Yoon et al., 2008) Egg (Koch et al., 2008) SetDB1 (Phalke et al., 2009) SETDB1 (Seum et al., 2007, Gou et al., 2010)
Name Synonym	dSETDB1 (Mis et al., 2006) eggless (Hazelrigg, 2006.3.6, Clough et al., 2006, Nurminsky, 2007, Clough et al., 2007, Brower-Toland et al., 2009, Hines et al., 2009) Eggless (Koch et al., 2008, Koch et al., 2009) Histone-lysine N-methyltransferase (Anholt and Williams, 2010)
Secondary FlyBase IDs
	FBgn0035061 FBgn0050422 FBgn0050426 FBgn0065010
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 4 ) Conference report  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Cryderman et al., 2011, Transcription 2(2): 95--99 Heterochromatin protein 1a is required for an open chromatin structure. [FBrf0213370] Koryakov et al., 2011, Chromosome Res. 19(2): 235--249 The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster. [FBrf0213472] Rangan et al., 2011, Curr. Biol. 21(16): 1373--1379 piRNA Production Requires Heterochromatin Formation in Drosophila. [FBrf0214714] Anholt and Williams, 2010, Chem. Senses 35(1): 21--30 The soluble proteome of the Drosophila antenna. [FBrf0209552] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Gou et al., 2010, PLoS ONE 5(5): e10581 SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila. [FBrf0210815] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...