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Gene Dmel\l(3)neo38

General Information
Symbol	Dmel\l(3)neo38	Species	D. melanogaster
Name	lethal (3) neo38	Annotation symbol	CG6930
Feature type	protein_coding_gene	FlyBase ID	FBgn0086910
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	CG14725
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E18-86E18	Sequence location	3R:7,590,760..7,604,886 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (3) neo38 is referred to in FlyBase by the symbol Dmel\l(3)neo38 (CG6930, FBgn0086910). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: regulation of chromatin silencing. 27 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 11 annotated transcripts and 11 annotated polypeptides. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. Gene sequence location is 3R:7590760..7604886.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features BKN34201 HFA16138 BKN31603 HFA14946 BKN30684
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E18-86E18   Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86F1-86F11   (determined by in situ hybridisation)   (Spradling et al., 1999) 86F1-86F11     (BDGP Project Members, 1994-1999) 86F-86F   (determined by in situ hybridisation)   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(3)neo38 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(3)neo38-RA FBtr0082533  NM_141856   1522   380 l(3)neo38-RB FBtr0110876  NM_001043243   6229   447 l(3)neo38-RC FBtr0110877  NM_001043244   2244   447 l(3)neo38-RD FBtr0305186     4956   434 l(3)neo38-RE FBtr0307081     1511   373 l(3)neo38-RF FBtr0307082     1417   373 l(3)neo38-RG FBtr0307083     3808   360 l(3)neo38-RH FBtr0307084     5054   373 l(3)neo38-RI FBtr0307085     1411   373 l(3)neo38-RJ FBtr0307086     3727   360 l(3)neo38-RK FBtr0307087     1611   447
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(3)neo38-PA   FBpp0082007   40.4   380   10.08     NP_650113   AAF54696 l(3)neo38-PB   FBpp0110176   47.1   447   10.03     NP_001036708   AAN13528 l(3)neo38-PC   FBpp0110177   47.1   447   10.03     NP_001036709   ABI31165 l(3)neo38-PD   FBpp0293716   45.5   434   10.06       l(3)neo38-PE   FBpp0297924   39.6   373   10.08       l(3)neo38-PF   FBpp0297925   39.6   373   10.08       l(3)neo38-PG   FBpp0297926   38.1   360   10.10       l(3)neo38-PH   FBpp0297927   39.6   373   10.08       l(3)neo38-PI   FBpp0297928   39.6   373   10.08       l(3)neo38-PJ   FBpp0297929   38.1   360   10.10       l(3)neo38-PK   FBpp0297930   47.1   447   10.03
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141458   AA433263   AA433276   AA694871   AE014297 AAF54696   AE014297 AAN13528   AE014297 ABI31165   AI109744   AI135433   AI390033   AQ034103   AY070621 AAL48092   AY119215 AAM51075   BI142014   BI163270   BI358243   BI364196   BI365781   BI370919   BI372974   BI577576   BI578793   BI579999   BI580872   BP556545   BP556546   BT006018   BT125573   BT125681   CK132041   CO177487   CO178015   CO187242   CO189490   CO262696   CO262916   CO264162   CO267947   CO273729   CO279510   CO279859   CO279990   CO286863   CO287903   CO289711   CO289717   CO290029   CO290462   CO290500   CO292332   CO294494   CO294641   CO298579   CO298771   CO300018   CO301449   CO302041   CO303165   CO305310   CO307079   CO308599   CO310672   CO311517   CO314314   CO317908   CO319921   CO320252   CO326780   CO329181   CO331581   CO333953   CO339217   CO342151   CO345295   CZ473291   CZ474258   CZ475579   CZ477586   CZ479296   EC058143   EC058267   EC058818   EC059188   EC060245   EC061752   EC063917   EC064542   EC067150   EC067171   EC068344   EC068593   EC070376   EC072272   EC072796   EC073716   EC075384   EC075614   EC076624   EC077488   EC079779   EC079920   EC080368   EC082008   EC085727   EC090513   EC090804   EC091152   EC195701   EC196145   EC196758   EC197082   EC198032   EC198312   EC199267   EC201104   EC203094   EC203607   EC204614   EC208792   EC210479   EC211096   EC212764   EC213459   EC213688   EC217528   EC217868   EC218929   EC219101   EC221196   EC224376   EC224588   EC225262   EC227071   EC231097   EC232545   EC240418   EC242160   EC242270   EC245061   EC246152   EC246889   EC248777   EC250012   EC251721   EC252965   EC254059   EC254246   EC254269   EC254434   EC256629   EC257569   EC258391   EC260463   EG974114   EL878127   EL878247   GH749714   GH749918   GH750844   GH752141   GH752217   GH753896   GH761238   GH771590   GH772622   GH772767   GH773109   GH773708   GH774584   GH774594   GH777932   GH777956   GH784017   GH785325   GH788535   GH788568   GH793775   GH799495   GH799800   GH808609   GH809365   GH809640   GH810257   GH810278   GH811314   GH816609   GH819200   GH821674   GH822288   GH824338   GH829796   GH830821   GH832723   GH838724   GH839570   GH847332   GH848873   GH849154   GH849350   GH852836   GH854951   GH855809   GH856411   GH856424   GH858473   GH860305   GH860961   GH861715   GH861912   GH865679   GH872657   GH873664   GH874244   GH875433   GH876055   GH877402   GH878293   GH878626   GH879940   GH887540   GH888074   GH894521   GH896670   GH896861   GH897702   GH898886   GH902124   GH903803   GH905845   GH907140   GH907738   GH911398   GH911790   GH912169   GH913696   GH915457   GH915696   GH920061   GH920987   GH922030   GH924769   GH925121   GH929262   GH933074   GH933917   GH935751   GH939873   GH940107   GH941408   GH949231   GH951785   GH953618   GH955358   GH955798   GH956395   GH956621   GH959994   GH962026   GH962136   GH962979   GH963807   GH964238   GH968181   GH969029   GH972115   GH972203   GH977673   GH978285   GH978355   GH979998   GH980441
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MRX4 Q8SZN9 Q7KSP5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086910    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086910 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086910 expression level Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr    12944 embryo 08-10hr    12322 embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (332) embryo 02-04hr  (3469) embryo 04-06hr  (9648) embryo 06-08hr  (12944) embryo 08-10hr  (12322) embryo 10-12hr  (9135) embryo 12-14hr  (7081) embryo 14-16hr  (5807) embryo 16-18hr  (2733) embryo 18-20hr  (1756) embryo 20-22hr  (940) embryo 22-24hr  (898) larva L1  (1018) larva L2  (426) larva L3 12hr old  (317) larva L3 puffstage 1-2  (492) larva L3 puffstage 3-6  (1914) larva L3 puffstage 7-9  (2250) white prepupae new  (2880) white prepupae 12hr  (3102) white prepupae 24hr  (3229) pupae 2d postWPP  (1632) pupae 3d postWPP  (452) pupae 4d postWPP  (569) adult male 01day  (486) adult male 05day  (477) adult male 30day  (444) adult female 01day  (521) adult female 05day  (257) adult female 30day  (294) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr  (3469) embryo 04-06hr  (9648) embryo 06-08hr  (12944) embryo 08-10hr  (12322) embryo 10-12hr  (9135) embryo 12-14hr  (7081) embryo 14-16hr  (5807) embryo 16-18hr  (2733) embryo 18-20hr  (1756) embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6  (1914) larva L3 puffstage 7-9  (2250) white prepupae new  (2880) white prepupae 12hr  (3102) white prepupae 24hr  (3229) pupae 2d postWPP  (1632) pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr  (12944) embryo 08-10hr  (12322) embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr    12944 embryo 08-10hr    12322 embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086910 expression level Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr    12944 embryo 08-10hr    12322 embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (332) embryo 02-04hr  (3469) embryo 04-06hr  (9648) embryo 06-08hr  (12944) embryo 08-10hr  (12322) embryo 10-12hr  (9135) embryo 12-14hr  (7081) embryo 14-16hr  (5807) embryo 16-18hr  (2733) embryo 18-20hr  (1756) embryo 20-22hr  (940) embryo 22-24hr  (898) larva L1  (1018) larva L2  (426) larva L3 12hr old  (317) larva L3 puffstage 1-2  (492) larva L3 puffstage 3-6  (1914) larva L3 puffstage 7-9  (2250) white prepupae new  (2880) white prepupae 12hr  (3102) white prepupae 24hr  (3229) pupae 2d postWPP  (1632) pupae 3d postWPP  (452) pupae 4d postWPP  (569) adult male 01day  (486) adult male 05day  (477) adult male 30day  (444) adult female 01day  (521) adult female 05day  (257) adult female 30day  (294) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr  (3469) embryo 04-06hr  (9648) embryo 06-08hr  (12944) embryo 08-10hr  (12322) embryo 10-12hr  (9135) embryo 12-14hr  (7081) embryo 14-16hr  (5807) embryo 16-18hr  (2733) embryo 18-20hr  1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6  1914 larva L3 puffstage 7-9  2250 white prepupae new  (2880) white prepupae 12hr  (3102) white prepupae 24hr  (3229) pupae 2d postWPP  1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr  12944 embryo 08-10hr  12322 embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    332 embryo 02-04hr    3469 embryo 04-06hr    9648 embryo 06-08hr    12944 embryo 08-10hr    12322 embryo 10-12hr    9135 embryo 12-14hr    7081 embryo 14-16hr    5807 embryo 16-18hr    2733 embryo 18-20hr    1756 embryo 20-22hr    940 embryo 22-24hr    898 larva L1    1018 larva L2    426 larva L3 12hr old    317 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    1914 larva L3 puffstage 7-9    2250 white prepupae new    2880 white prepupae 12hr    3102 white prepupae 24hr    3229 pupae 2d postWPP    1632 pupae 3d postWPP    452 pupae 4d postWPP    569 adult male 01day    486 adult male 05day    477 adult male 30day    444 adult female 01day    521 adult female 05day    257 adult female 30day    294 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086910    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086910 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086910 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for l(3)neo38 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI l(3)neo38LAS146 lethal | recessive l(3)neo381 semi-lethal | recessive l(3)neo381 l(3)neo3802 viable l(3)neo38CA06556 viable, with Scer\GAL4pnr-MD237 l(3)neo38GD12076 l(3)neo38GD17123 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 l(3)neo38GD12076 l(3)neo38GD17123 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 l(3)neo38GD12076 mesothoracic tergum, with Scer\GAL4pnr-MD237 l(3)neo38GD12076 l(3)neo38GD17123
Classical Alleles ( 24 )
For All Classical Alleles Show
Allele of l(3)neo38 Class Mutagen Stocks Known lesion l(3)neo3802 1 Yes l(3)neo381 P-element activity 1 Yes l(3)neo385-HA-1560 1 -- l(3)neo385-HA-1823 1 -- l(3)neo38c01191 1 -- l(3)neo38c03131 1 -- l(3)neo38CB-0491-3 1 -- l(3)neo38d03325 P-element activity 1 -- l(3)neo38d05010 P-element activity 1 -- l(3)neo38e01481 piggyBac transposase 1 -- l(3)neo38KG00059 1 -- l(3)neo38KG01200 1 -- l(3)neo38MI01923 1 -- l(3)neo38NP0970 1 -- l(3)neo38NP4640 1 -- l(3)neo38NP4779 1 -- l(3)neo38[EY07970] P-element activity 1 -- l(3)neo38c00790 0 -- l(3)neo38CA06556 P-element activity 0 Yes l(3)neo38d01950 0 -- l(3)neo38d04629 0 -- l(3)neo38d07181 P-element activity 0 -- l(3)neo38d11157 P-element activity 0 -- l(3)neo38LAS146 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(3)neo38 Class Mutagen Stocks Known lesion l(3)neo38GD12076 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes l(3)neo38GD17123 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes l(3)neo38KK110684 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7310 (Ryder, 2004.4.26) Df(3R)M-Kx1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12076} NA P{GD17123} NA P{KK110684} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}l(3)neo38MI01923 NA P{hsneo}l(3)neo381 NA P{PTT-GA}l(3)neo38CA06556 NA P{RS3}l(3)neo38CB-0491-3 NA P{RS5}l(3)neo385-HA-1560 NA P{RS5}l(3)neo385-HA-1823 NA P{SUPor-P}KG08621 NA P{SUPor-P}l(3)neo38KG00059 NA P{SUPor-P}l(3)neo38KG01200 NA P{UAST-YFP.Rab2}l(3)neo3802 NA PBac{PB}l(3)neo38c00790 NA PBac{PB}l(3)neo38c01191 NA PBac{PB}l(3)neo38c03131 NA PBac{RB}l(3)neo38e01481 NA insertion of mobile activating element P{EPgy2}l(3)neo38EY07970 NA P{GSV1}C547C547 NA P{GSV1}GSd452GSd452 NA P{Mae-UAS.6.11}l(3)neo38LAS146 NA P{XP}l(3)neo38d01950 NA P{XP}l(3)neo38d03325 NA P{XP}l(3)neo38d04629 NA P{XP}l(3)neo38d05010 NA P{XP}l(3)neo38d07181 NA P{XP}l(3)neo38d11157 NA insertion of enhancer trap binary system P{GAL4}ikar1 No P{GawB}l(3)neo38NP0970 No P{GawB}l(3)neo38NP4640 No P{GawB}l(3)neo38NP4779 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of chromatin silencing inferred from mutant phenotype (Schneiderman et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(3)neo38 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66546 DroID - A comprehensive database of gene and protein interactions. • FBgn0086910 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41423
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA19962
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011304-PA Aedes aegypti (mosquito) AGAP004178-PA Anopheles gambiae (mosquito) XP_001944474.1 Acyrthosiphon pisum (pea aphid) 88507 Batrachochytrium dendrobatidis (chytrid fungus) CE40380 Caenorhabditis elegans (worm) 170128 Hypsipyla robusta (cedar shoot borer) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16704 NV16614 LH12771 FBgn0239071 FBgn0227969 FBgn0219173 FBgn0213994 FBgn0201269 FBgn0197445 FBgn0192103 FBgn0186000 FBgn0180928 FBgn0180144 JGI_V11_50915 FBgn0080297 FBgn0079958 FBgn0160397 FBgn0149856 FBgn0136464 FBgn0133068 FBgn0036179 FBgn0130617 FBgn0122335 FBgn0109422 FBgn0107763 FBgn0102268 FBgn0093638 CPIJ016287 CPIJ001334 CPIJ001178 BGIBMGA005626 BGIBMGA005627 ACYPI004878 ACYPI004340 ACYPI000727 GB19463 GB13693 AGAP011548 AGAP004178 AGAP001269 AAEL011664 AAEL011304 AAEL007260 PB20879 PHUM430410 PHUM430420 GLEAN_15472 GLEAN_15473
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Harvard	- P{XP}l(3)neo38d03325 - P{XP}l(3)neo38d05010 - PBac{PB}l(3)neo38c01191 - PBac{PB}l(3)neo38c03131 - PBac{RB}l(3)neo38e01481
Kyoto	123201 w1118; P{RS3}l(3)neo38CB-0491-3 125258 w1118; P{RS5}l(3)neo385-HA-1560
VDRC	v107927 P{KK110684}VIE-260B v35145 w1118; P{GD12076}v35145 v35147 w1118; P{GD12076}v35147 v46831 w1118; P{GD17123}v46831 v46830 w1118; P{GD17123}v46830/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR03D22 BACR11G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 255 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM07658 LP14345 RE64859 RE72719 SD16005
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09034 GH13205 GH21481 GM01705 LP13255 RE02624 RE44951 RE49260 RE51160 RE57694 RE60176 RE71277 RE74117 RE75107
Other clones	1928 10989 11898 20945 28350 29102 31933 36977 38076 38883 39147 50544 50915 58586 58971 69956 71481 75083 75400 76365 76366 78211 96991 99445 102005 102931 107055 118631 120477 147925 148878 164896 165000 176692 178340 178955 214243.56 214253.48 214309.50 214315.52 214377.48 214439.63 214471.47 214473.49 214475.48 214543.46 273299 282731 AA433263 AA433276 CK01.2D.F6 CK01.8D.A10 CK01.13B.E4 CK01.17C.H3 CK01.18B.C6 CK01.28B.A8 CK01.31D.E6 CK01.63D.H4 CK01.65D.E10 CK01.68D.E1 CK01.84C.F9 CK01.84C.H8 CK01.91D.C8 CK01.91D.G8 CK01.93C.E1 CK01.95A.F10 CK01.95B.F4 CK01.102B.F7 CK01.103B.F11 CK01.117B.E1 CK01.117C.B12 CK01.118A.B6 CK01.132D.H2 CK01775 EK027451 EK044408 EK053649 EK055013 EK064062 EK067117 EK071844 EK071860 EK072917 EK074041 EK074154 EK086124 EK086822 EK089730 EK112028 EK134917 EK136213 EK137646 EK152155 EK173303 EK173830 EK177233 EK180964 EK182939 EK199849 EK207054 EK207341 EK222249 EK224763 EK235738 EK240336 EK248201 EK253458 EK258825 EK269661 EK281431 EK283131 EK292202 EK300561 EK308440 EP01239 EP04622 EP13949 EP21753 FGM304B07 IP08030 IP08130 RP003024016 RP003050291 RP003052328 RP003054635 RP003061054 RP003068126 RP003068940 RP003069473 RP003074476 RP003074910 RP003081303 RP003082947 RP003084715 RP003090303 RP003093648 RP003093795 RP003093802 RP003097670 RP003098591 RP003100755 RP003113826 RP003114558 RP003119599 RP003133017 RP003133876 RP003135045 RP003135475 RP003138058 RP003138548 RP003153725 RP003156541 RP003157794 RP003175888 RP003178651 RP003182277 RP003191656 RP003198519 RP003199329 RP003199719 RP003212558 RP003218772 RP003220433 RP003234924 RP003236338 RP003239113 RP003241065 RP003256729 RP003276741 RP003288991 RP003300618 RP003307415 RP003308841 RP003314090 RP003320789 RP003326467 RP003333303 RP003347338 RP003349047 RP003355079 RP003356827 RP003363658 RP003366585 RP003373727 RP003376324 RP003389351 RP003392456 RP003396184 RP003400591 RP003405911 RP003435278 RP003460609 RP003460818 RP003500954 RP003505746 RP003510492 RP003525646 RP003532142 RP003533130 RP003541306 RP003542028 RP003606185 RP003619769 RP003628568 RP003639844 RP003642568 RP003649138 RP003655402 RP003663268 RP003666220 RP003666381 RP003671205 RP003671908 RP004075307 RP004079617 RP004090819 RP004099694 RP004126734 RP004153629 RP004186864 RP004240706 RP004243852 RP004261210 RP004261623 RP004268760 RP004283346 RP004400905 RP004402048 RP004446540 RP004458970 RP004505994 RP004510264 RP004519640 RP004527632 RP004529678 RP004551230
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086910 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41423 318699
Antibody Information
Other Information
Discoverer
	A. Spradling.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(3)neo38 BcDNA:SD16005 (FlyBase Genome Annotators, 2006, FlyBase, 1996-) Source for merge of: l(3)neo38 CG31364 (Levis, 2003.3.6)
Additional comments	Source for merge of l(3)neo38 BcDNA:SD16005 was a shared cDNA (date:030728). (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
Other Comments
	New annotation (CG31364) in release 3 of the genome annotation. Annotation CG14725 was eliminated in release 3 of the genome annotation, October 2002. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141856 NM_001043243 NM_001043244 RefSeq (Proteins) • NP_650113 NP_001036708 NP_001036709 DDBJ / EMBL / GenBank • AAF54696 AAL48092 AAM51075 AAN13528 ABI31165 AI135433 AQ034103 AY070621 AY119215 BI142014 BI578793 CZ473291 CZ474258 CZ475579 CZ477586 CZ479296 Entrez Gene - A searchable database of RefSeq genes. • 41423 UniProtKB/TrEMBL • Q7KSP5 Q8MRX4 Q8SZN9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66546 DroID - A comprehensive database of gene and protein interactions. • FBgn0086910 DRSC - Results from RNAi screens. • FBgn0086910 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086910 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086910 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41423 318699 InParanoid A subset of ortholog calls from InParanoid. • AAEL011304-PA Aedes aegypti (mosquito) AGAP004178-PA Anopheles gambiae (mosquito) XP_001944474.1 Acyrthosiphon pisum (pea aphid) 88507 Batrachochytrium dendrobatidis (chytrid fungus) CE40380 Caenorhabditis elegans (worm) 170128 Hypsipyla robusta (cedar shoot borer) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41423 modMine - Data generated by the modENCODE project. • FBgn0086910 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16704 NV16614 LH12771 FBgn0239071 FBgn0227969 FBgn0219173 FBgn0213994 FBgn0201269 FBgn0197445 FBgn0192103 FBgn0186000 FBgn0180928 FBgn0180144 JGI_V11_50915 FBgn0080297 FBgn0079958 FBgn0160397 FBgn0149856 FBgn0136464 FBgn0133068 FBgn0036179 FBgn0130617 FBgn0122335 FBgn0109422 FBgn0107763 FBgn0102268 FBgn0093638 CPIJ016287 CPIJ001334 CPIJ001178 BGIBMGA005626 BGIBMGA005627 ACYPI004878 ACYPI004340 ACYPI000727 GB19463 GB13693 AGAP011548 AGAP004178 AGAP001269 AAEL011664 AAEL011304 AAEL007260 PB20879 PHUM430410 PHUM430420 GLEAN_15472 GLEAN_15473
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:SD16005   CG6930 (Brody et al., 2002, Giot et al., 2003, Buszczak et al., 2007, Peng et al., 2007, Keleman et al., 2009.8.5, Magalhaes et al., 2007, Schneiderman et al., 2010) CG14725 (Luschnig, 2003.12.17, Akdemir et al., 2007) CG31364 (Molnar et al., 2006) l(3)neo38 (Zhang et al., 2007, Molnar et al., 2006, Minidorff et al., 2007, Schneiderman et al., 2010, Hoskins et al., 2011)
Name Synonym	lethal (3) neo38
Secondary FlyBase IDs
	FBan0006930 FBgn0011471 FBgn0037947 FBgn0037948 FBgn0051364 FBgn0062876
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 5 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Hoskins et al., 2011, Genome Res. 21(2): 182--192 Genome-wide analysis of promoter architecture in Drosophila melanogaster. [FBrf0213090] Schneiderman et al., 2010, PLoS Genet. 6(9): e1001095 Perturbation Analysis of Heterochromatin-Mediated Gene Silencing and Somatic Inheritance. [FBrf0211786] Show all research papers ...