PHD finger superfamily protein - a nucleolar protein required for small ribosomal subunit biogenesis - transcriptionally regulated by Myc which relays information from nutrient dependent signaling pathways to ribosomal gene expression - part of the Myc and CK2 regulatory networks for coordination of neuroblast growth and proliferation
Gene model reviewed during 5.39
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
May be phosphorylated in vivo by CkIIalpha. mbm and CkIIalpha colocalize to the nucleolus and mbm is phosphorylated in vitro by CkIIalpha.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mbm using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mbm in GBrowse 2
Maps meiotically to distal 2L.
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
mbm mutants exhibit a striking sexual dimorphism, mushroom bodies of females are completely absent while those of males are reduced by 30%. All mutant are impaired in associative odour learning and memory.
mbm males display courtship behaviour similar to that of wild type males although courtship intensity is reduced. This suggests that mushroom bodies do not play an important role in male courtship behaviour.
Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.
All three mbm alleles, when heterozygous with Df(2L)al, lead to stronger mutant phenotypes than mutant homozygotes or heteroallelic combinations; mbmK1/mbmK7 causes a very weak (i.e., near normal) mushroom body defect. mbmK1 and mbmK7 are from stocks originally termed "Df(2L)netK1" and "Df(2L)netK7"; each of these turns out not to be a deletion, i.e. they appear to be cytologically normal, but the former is mutant for net, mbm and a vital gene, as is the latter, though the lethal here complements that on the K1 chromosome. In both of these stocks, the various abnormalities are separable by recombination. Isolation: Mutagenized second chromosome provided by C. Nusslein-Volhard.
H. Heisenberg and K. Fischbach.