FlyBase Gene Report: Dmel\Rab26

General Information

Symbol

Dmel\Rab26

Species

D. melanogaster

Name

Rab26

Annotation Symbol

CG34410

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086913

Gene Model Status

Current

Stock Availability

38 publicly available

Gene Summary

Participates in exocrine secretion. (UniProt, Q9VP48)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DmRab26

Key Links

Genomic Location

Cytogenetic map

78C7-78C7

Sequence location

3L:21,318,774..21,335,027 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21318774..21335027

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN004662974

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P51156

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN004662974

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in symbiont entry into host cell

inferred from high throughput mutant phenotype

(Hodgson et al., 2019)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in Rab protein signal transduction

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

involved_in regulation of exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN001179116

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P51156

(Gene Ontology Curators, 2002-)

involved_in vesicle-mediated transport

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in recycling endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in synapse

inferred from high throughput direct assay

(Chan et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in endosome

inferred from biological aspect of ancestor with PANTHER:PTN000635999

(GO Reference Genome Project, 2011-)

is_active_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN000635999

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with UniProtKB:P51156

(Gene Ontology Curators, 2002-)

located_in vesicle

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

RAB GTPASES

Protein Family (UniProt)

Belongs to the small GTPase superfamily. Rab family. (Q9VP48)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Group (FlyBase)

RAB GTPASES -: The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).

Protein Function (UniProtKB)

Participates in exocrine secretion.

(UniProt, Q9VP48)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rab26 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VP48)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rab26-RB

FBtr0112677

NM_141046

2518

388

Rab26-RC

FBtr0112678

NM_001104188

2078

410

Rab26-RD

FBtr0301529

NM_001170017

1658

410

Rab26-RE

FBtr0331794

NM_001275222

3311

410

Rab26-RF

FBtr0331795

NM_001275223

1547

373

Rab26-RG

FBtr0345428

NM_001300213

3355

388

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rab26-PB

FBpp0111589

43.0

388

6.48

FBpp0111590

45.1

410

9.55

FBpp0290744

45.1

410

9.55

FBpp0304179

45.1

410

9.55

FBpp0304180

40.9

373

9.29

FBpp0311553

43.0

388

6.48

Q9VP48

NP_001287142

AHN58167

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

388 aa isoforms: Rab26-PB, Rab26-PG

410 aa isoforms: Rab26-PC, Rab26-PD, Rab26-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab26 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in recycling endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in synapse

inferred from high throughput direct assay

(Chan et al., 2011)

Expression Deduced from Reporters

Reporter: PBac{I-SceI(FRT.Rab26-GAL4.ex1(loxP.3xP3-RFP))}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6 -- P7

neuron | subset of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab26 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rab26

View exonic expression by tissue for Dmel\Rab26

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086913

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40359/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086913

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086913

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086913

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7605

Flygut - An atlas of the Drosophila adult midgut

FBgn0086913

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rab26

Transgenic constructs containing regulatory region of Rab26

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Scer\GAL4^Mef2.PR

Rab26^GD9927

viable, with Scer\GAL4^pnr-MD237

Rab26^GD9927

Sterility

Allele

fertile

Rab26^CRISPR

Other Phenotypes

Allele

abnormal neuroanatomy | adult stage

Rab26^CRISPR

abnormal neurophysiology | adult stage

Rab26^CRISPR

Phenotype manifest in

Allele

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Rab26^{Q250L.UAS.YFP}

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Rab26^{Q250L.UAS.YFP}

outer photoreceptor cell | adult stage

Rab26^CRISPR

prepupa

retina

Rab26^CRISPR

rhabdomere of eye photoreceptor cell | adult stage

Rab26^CRISPR

salivary gland | larval stage

Rab26^CRISPR

salivary gland | prepupal stage

secretory granule | ectopic | prepupal stage

Rab26^EYFP

secretory granule | larval stage

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (53)

Hsap\RAB26

11 of 14

Yes

Hsap\RAB37

9 of 14

Yes

Hsap\CPLANE2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Rab26

10 of 14

Yes

Rnor\Rab37

8 of 14

Yes

Rnor\Cplane2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Rab26

11 of 14

Yes

Mmus\Rab37

8 of 14

Yes

Mmus\Cplane2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (27)

Xtro\rab26

8 of 13

Yes

Xtro\nipsnap2

6 of 13

Xtro\rab37

6 of 13

Yes

Xtro\cplane2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (22)

Drer\LOC101885697

8 of 14

Yes

Drer\cplane2

1 of 14

Yes

Drer\LOC101882208

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:171927

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (22)

Cele\rab-37

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP000671

1 of 12

Yes

Agam\AgaP_AGAP001211

1 of 12

Yes

Agam\AgaP_AGAP001617

1 of 12

Yes

Agam\AgaP_AGAP001874

1 of 12

Yes

Agam\AgaP_AGAP002092

1 of 12

Yes

Agam\AgaP_AGAP003028

1 of 12

Yes

Agam\AgaP_AGAP004146

1 of 12

Yes

Agam\AgaP_AGAP005159

1 of 12

Yes

Agam\AgaP_AGAP005248

1 of 12

Yes

Agam\AgaP_AGAP005255

1 of 12

Yes

Agam\AgaP_AGAP005393

1 of 12

Yes

Agam\AgaP_AGAP006159

1 of 12

Yes

Agam\AgaP_AGAP006873

1 of 12

Yes

Agam\AgaP_AGAP007699

1 of 12

Yes

Agam\AgaP_AGAP008419

1 of 12

Yes

Agam\AgaP_AGAP009325

1 of 12

Yes

Agam\AgaP_AGAP011283

1 of 12

Yes

Agam\AgaP_AGAP011306

1 of 12

Yes

Agam\AgaP_AGAP011363

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (40)

Atha\RAB11c

2 of 13

Yes

Atha\RABA2b

2 of 13

Yes

Atha\RABA2c

2 of 13

Yes

Atha\RABA2D

2 of 13

Yes

Atha\RABA4a

2 of 13

Yes

Atha\RABA4B

2 of 13

Yes

Atha\RABA4D

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SGP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\GSP1

1 of 13

Yes

Scer\GSP2

1 of 13

Yes

Scer\RSR1

1 of 13

Yes

Scer\SEC4

1 of 13

Yes

Scer\TEM1

1 of 13

Yes

Scer\YPT1

1 of 13

Yes

Scer\YPT6

1 of 13

Yes

Scer\YPT31

1 of 13

Yes

Scer\YPT32

1 of 13

Yes

Scer\YPT53

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\spg1

1 of 12

Yes

Spom\ypt1

1 of 12

Yes

Spom\ypt2

1 of 12

Yes

Spom\ypt3

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rab26. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (39)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Ran

1 of 13

Rap1

1 of 13

Ras85D

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Rab26^GD9927

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Merlo et al., 2014)

Rab26^UAS.YFP

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Merlo et al., 2014)

Rab26^{T204N.UAS.YFP}

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Merlo et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RAB26; RAB26, member RAS oncogene family

11 of 14

605455

RAB37; RAB37, member RAS oncogene family

9 of 14

609956

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rab26 - CG13531

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab26 - Pgam5

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab26 - Pxn

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab26 - Sptz

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab26 - faf

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab26 - sgg

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Osbp

suppressible

Rab26

(Ma et al., 2012)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65607

DroID - A comprehensive database of gene and protein interactions.

FBgn0086913

MIST (protein-protein) - An integrated Molecular Interaction Database

40359

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011, Stapleton et al., 2006)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

78C7-78C7

Sequence location

3L:21,318,774..21,335,027 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78C7-78C7

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (38)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

71642

w¹¹¹⁸; P{VT034258-p65.AD}attP40

74302

w¹¹¹⁸; P{VT034255-p65.AD}attP40

74303

w¹¹¹⁸; P{VT034259-p65.AD}attP40

74498

w¹¹¹⁸; P{VT034252-p65.AD}attP40

Korea

12700

P{VT034252-GAL4}attP2

13492

P{VT034255-GAL4}attP2

14871

P{VT034258-GAL4}attP2

14937

P{VT034259-GAL4}attP2

7605R-2

32439R-2

v101330

v43730

w¹¹¹⁸; P{GD9927}v43730

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086913

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086913

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Kouranti et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Rab26 CG32439

(FlyBase Genome Annotators, 2007)

Additional comments

The Rab26 gene may have been derived from the Rab3 gene by retroposition.

(Pan and Zhang, 2009)

Annotations CG7605 and CG32439 merged as CG34410 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Release 2 annotation CG7605 split into CG7605, CG32439 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

AAF51708

(Armstrong, 2000)

CG32439

(Japanese National Institute of Genetics, 2012.5.21, Pan and Zhang, 2009)

CG34410

(Dunst et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Li et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2008, Sinka et al., 2008, FlyBase Genome Annotators, 2007)

CG7605

(Zhang et al., 2007, Colicelli, 2004, Giot et al., 2003)

DmRab26

(Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)

Q8IPT6

(Rojas et al., 2012)

Q9VP48

(Rojas et al., 2012)

rab26

(Lammers et al., 2017, Kanamori et al., 2015, van den Brink et al., 2013, Jin et al., 2012, Chan et al., 2011, Holtzman et al., 2005)

Name Synonyms

CG32439

Rab26

Secondary FlyBase IDs

FBgn0037072
FBgn0052439
FBgn0085439
FBan0032439

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

Rab_Effectors_interaction_map

interactome

Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40359

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VP48

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VP48

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VP48

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086913

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40359/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086913

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086913

FlyMine - An integrated database for Drosophila genomics

FBgn0086913

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34410

MARRVEL_MODEL - MARRVEL (model organism gene)

40359

Linkouts

BioGRID - A database of protein and genetic interactions.

65607

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086913

DroID - A comprehensive database of gene and protein interactions.

FBgn0086913

DRSC - Results frm RNAi screens

FBgn0086913

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086913

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086913

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7605

Flygut - An atlas of the Drosophila adult midgut

FBgn0086913

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0086913

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011797

MIST (protein-protein) - An integrated Molecular Interaction Database

40359

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

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