FlyBase Gene Report: Dmel\bbg

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bbg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (5 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

border follicle cell migration

inferred from mutant phenotype

(Aranjuez et al., 2012)

innate immune response in mucosa

inferred from mutant phenotype

(Bonnay et al., 2013)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

apical part of cell

inferred from direct assay

(Bonnay et al., 2013)

nucleus

inferred from direct assay

(Kim et al., 2006)

septate junction

inferred from direct assay

(Bonnay et al., 2013)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

posterior endoderm anlage

(Kim et al., 2006)

embryonic stage 5 -- 6

mesectoderm

(Kearney et al., 2004)

embryonic stage 6 -- 10

dorsal ectoderm

(Kim et al., 2006)

embryonic stage 6 -- 12

posterior midgut primordium

(Kim et al., 2006)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

mesectoderm anlage

(Kearney et al., 2004)

inclusive hindgut primordium

(Kim et al., 2006)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium

(Kearney et al., 2004)

anterior midgut primordium

(Kim et al., 2006)

hindgut proper primordium

(Kim et al., 2006)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

embryonic stage 11 -- 15

foregut primordium

(Kim et al., 2006)

embryonic stage 12 -- 15

small intestine primordium

(Kim et al., 2006)

embryonic stage 13

posterior spiracle primordium

(Kim et al., 2006)

embryonic stage 16 -- 17

embryonic/larval proventriculus

(Kim et al., 2006)

embryonic/larval pharynx

(Kim et al., 2006)

Keilin's organ

(Kim et al., 2006)

mechanosensory sensory organ of embryonic abdominal segment

(Kim et al., 2006)

embryonic/larval posterior spiracle

(Kim et al., 2006)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Kim et al., 2006)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ovary

(Aranjuez et al., 2012)

Additional Descriptive Data

During embryogenesis, bbg transcript is predominantly expressed in the developing gut. bbg transcript is first detected at embryonic stage 5, in the posterior endoderm anlage. bbg transcript is expressed in posterior midgut primordium by stage 6, in the invaginating hindgut primordium by stage 7, in the anterior midgut primordium at stages 9-10, and in the forgut primordium by stages 11-12. Gut expression is maintained though late embryogenesis, and becomes restricted to the pharynx and proventriculus at late embryonic stages. bbg transcript expression in the dorsal ectoderm begins at embryonic stage 6; this expression is restricted to the dorsal edge of the dorsal ectoderm by embryonic stage 9-10. In the wing disc, bbg transcript is expressed at the presumptive wing margin, and in a small stripe perpendicular to the wing margin in the dorsal wing pouch. bbg transcript is expressed at the dorsal-ventral compartment boundary of the haltere disc. bbg transcript is expressed in a pair of cell clusters near the center of the leg discs; at the medial side of the antennal disc; in a ring-shaped pattern in the larval optic lobe; and at and posterior to the morphogenetic furrow of the eye disc. bbg transcript expression exhibits isoform-specificity at embryonic and larval stages.

(Kim et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 10

dorsal ectoderm

(Kim et al., 2006)

embryonic stage 6 -- 12

posterior midgut primordium

(Kim et al., 2006)

embryonic stage 7 -- 8

inclusive hindgut primordium

(Kim et al., 2006)

embryonic stage 9 -- 12

anterior midgut primordium

(Kim et al., 2006)

hindgut proper primordium

(Kim et al., 2006)

embryonic stage 11 -- 15

foregut primordium

(Kim et al., 2006)

embryonic stage 12 -- 15

small intestine primordium

(Kim et al., 2006)

embryonic stage 13

posterior spiracle primordium

(Kim et al., 2006)

embryonic stage 16 -- 17

embryonic/larval proventriculus

(Kim et al., 2006)

embryonic/larval pharynx

(Kim et al., 2006)

Keilin's organ

(Kim et al., 2006)

mechanosensory sensory organ of embryonic abdominal segment

(Kim et al., 2006)

wandering third instar larval stage

presumptive wing margin

(Kim et al., 2006)

ventral thoracic disc | distal

(Kim et al., 2006)

antennal disc | medial

(Kim et al., 2006)

eye disc posterior to the morphogenetic furrow

(Kim et al., 2006)

morphogenetic furrow

(Kim et al., 2006)

ommatidial precursor cluster

(Kim et al., 2006)

pupal stage P6 -- P7

eye photoreceptor cell

• apical plasma membrane

Comment: 30 hr APF

(Kim et al., 2006)

pupal stage P7 -- pharate adult stage P9

cone cell

• plasma membrane

Comment: 40-60 hr APF

(Kim et al., 2006)

pharate adult stage P8

interommatidial bristle

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

pharate adult stage P9

secondary pigment cell

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

tertiary pigment cell

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

adult stage

adult proventriculus

(Bonnay et al., 2013)

gut epithelium

(Bonnay et al., 2013)

adult midgut epithelium

(Bonnay et al., 2013)

oogenesis & adult stage | female

polar follicle cell

(Kim et al., 2006)

oocyte

• nucleus

(Kim et al., 2006)

adult stage | female & oogenesis stage S10

oocyte associated follicle cell

(Kim et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

Additional Descriptive Data

bbg protein is localized to the apical and lateral sides of gut epithelial cells.

(Bonnay et al., 2013)

During oogenesis, bbg protein is expressed in the profollicular mesoderm, a layer of follicle cells that separates the germline cyst found at the posterior end of the germarium, from the anterior neighbouring younger cyst; strongly expressed in polar follicle cells; weakly expressed in somatic follicle cells surrounding early egg chambers; in follicle cells surrounding the oocyte; and in the oocyte nucleus. During embryogenesis, bbg protein is predominantly expressed in the developing gut. bbg protein is first detected at embryonic stage 6, in the posterior midgut primordium. bbg protein is expressed in the invaginating hindgut primordium by stage 7, in the anterior midgut primordium at stages 9-10, and in the forgut primordium by stages 11-12. Gut expression is maintained though late embryogenesis, and becomes restricted to the pharynx and proventriculus at late embryonic stages. bbg protein expression in the dorsal ectoderm begins at embryonic stage 6; this expression is restricted to the dorsal edge of the dorsal ectoderm by embryonic stage 9-10. In the wing disc, bbg protein is expressed at the presumptive wing margin, and in a similar pattern in the haltere disc. bbg protein is expressed in a pair of cell clusters near the center of the leg discs; at the medial side of the antennal disc; in a ring-shaped pattern in the larval optic lobe; and at and posterior to the morphogenetic furrow of the eye disc. During pupal eye development, bbg protein is also specifically and dynamically expressed in cone cells, mechanosensory bristle cells, and in secondary and tertiary pigment cells as each cell type becomes specified.

(Kim et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

apical part of cell

inferred from direct assay

(Bonnay et al., 2013)

nucleus

inferred from direct assay

(Kim et al., 2006)

septate junction

inferred from direct assay

(Bonnay et al., 2013)

Expression Deduced from Reporters

Reporter: P{GawB}bbg^C96

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

abdominal sensory neuron

(Kim et al., 2006)

pharyngeal muscle

(Kim et al., 2006)

embryonic/larval salivary gland

(Kim et al., 2006)

mechanosensory neuron of embryonic/larval posterior spiracle

(Kim et al., 2006)

mechanosensory neuron of embryonic telson

(Kim et al., 2006)

larval stage

embryonic/larval central nervous system

(Kim et al., 2006)

third instar larval stage

dorsal-ventral compartment boundary of the wing disc

(Usha and Shashidhara, 2010)

wandering third instar larval stage

presumptive wing margin

(Kim et al., 2006, Gustafson and Boulianne, 1996)

mechanosensory neuron of wing hinge primordium

(Kim et al., 2006)

dorsal-ventral compartment boundary of the haltere disc

(Kim et al., 2006)

eye disc posterior to the morphogenetic furrow

(Kim et al., 2006)

presumptive second segment of antenna | restricted

(Kim et al., 2006)

antennal disc | restricted

(Gustafson and Boulianne, 1996)

oogenesis

polar follicle cell

Comment: early stages

(Aranjuez et al., 2012)

oogenesis stage S9 -- S10

border follicle cell

(Aranjuez et al., 2012)

follicle cell

(Aranjuez et al., 2012)

Reporter: P{ST.lexA::HG}bbg^DL-4

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval proventriculus

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval salivary gland

(Bloomington Drosophila Stock Center, 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bbg in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bbg

View exonic expression by tissue for Dmel\bbg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0087007

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0087007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9587-RA;CG9598-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9598

Flygut - An atlas of the Drosophila adult midgut

FBgn0087007

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\bbg

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 50 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bbg

Transgenic constructs containing regulatory region of bbg

Deletions and Duplications ( 1 )

Disrupted in

Df(3L)Exel6123

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

bbg^GD6101

Other Phenotypes

Allele

immune response defective | adult stage

bbg^B211

immune response defective | adult stage (with bbg^B211)

bbg^EY02818

immune response defective | adult stage (with bbg^EY02818)

bbg^B211

immune response defective | adult stage (with Df(3L)fz-GS1a)

bbg^EY02818

increased occurrence of cell division

bbg^B211

increased occurrence of cell division | adult stage

bbg^B211

short lived

bbg^B211

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

bbg^GD6101

some die during larval stage | recessive

Phenotype manifest in

Allele

adult midgut

bbg^B211

border follicle cell, with Scer\GAL4^c306

bbg^GD6101

imaginal disc

smooth septate junction

bbg^B211

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\IL16

3 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\USH1C

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Il16

4 of 15

Yes

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Mpdz

1 of 15

Mmus\Patj

1 of 15

Mmus\Pclo

1 of 15

Yes

Mmus\Pdzd11

1 of 15

Mmus\Pdzph1

1 of 15

Mmus\Ush1c

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Il16

2 of 13

Yes

Rnor\Pdzd2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Pdzd11

1 of 13

Xenopus tropicalis (Western clawed frog) (5)

Xtro\dlg5

1 of 12

Yes

Xtro\grid2ip

1 of 12

Yes

Xtro\grip1

1 of 12

Yes

Xtro\grip2

1 of 12

Yes

Xtro\lnx1

1 of 12

Yes

Danio rerio (Zebrafish) (14)

Drer\si:dkey-92i15.4

3 of 15

Yes

Drer\il16

2 of 15

Yes

Drer\aim1a

1 of 15

Yes

Drer\dlg5a

1 of 15

Drer\grid2ipa

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\pdzd2

1 of 15

Drer\pdzd7b

1 of 15

Drer\slc9a3r1a

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\C46H11.6

1 of 15

Yes

Cele\C50D2.3

1 of 15

Yes

Cele\C50F7.3

1 of 15

Yes

Cele\C52A11.3

1 of 15

Yes

Cele\F16G10.5

1 of 15

Yes

Cele\F20D6.1

1 of 15

Yes

Cele\F28E10.4

1 of 15

Yes

Cele\F40F9.3

1 of 15

Yes

Cele\let-413

1 of 15

Yes

Cele\mpz-1

1 of 15

Yes

Cele\mpz-4

1 of 15

Yes

Cele\smz-2

1 of 15

Yes

Cele\syd-1

1 of 15

Yes

Cele\unc-10

1 of 15

Yes

Cele\ZK849.1

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900O9 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\bbg

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21904

Drosophila persimilis

Dper\GL20990

Drosophila willistoni

Dwil\GK10321

Drosophila virilis

Dvir\GJ13937

Drosophila mojavensis

Dmoj\GI26407

Drosophila grimshawi

Dgri\GH14457

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

1 of 10

baz

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

inflammatory bowel disease, tight/septate junction defect

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

bbg^B211

model of inflammatory bowel disease

CEA

(Bonnay et al., 2013)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

IL16; interleukin 16

3 of 15

603035

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bbg - kst

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Forest et al., 2018)

bbg - sqh

anti tag coimmunoprecipitation, western blot

(Tsoumpekos et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

DCTN1-p150

enhanceable

bbg

(Chang et al., 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0087007

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39583

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q15K23

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70E1-70D7

Sequence location

3L:14,412,828..14,536,276 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70E1-70D7

Limits computationally determined from genome sequence between P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸ and P{PZ}Mpcp⁰⁰⁵⁶⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70D-70D

(determined by in situ hybridisation)

(Kim and Boulianne, 1998)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (45)

d00241

d03387

d05385

d05690

d07710

d08516

d09995

d11383

c02006

c02862

e01345

v101691

More stocks available...

Genomic Clones (63)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (153)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

RE18302

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0087007

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0087007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39583

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Forest et al., 2018, Tsoumpekos et al., 2018)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: bbg CG9587

(Kim et al., 2005.8.15)

Source for database merge of

Source for merge of: bbg CG9598 C96

(Kim et al., 2006)

Source for merge of: bbg CG9598

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG9598 and CG9587 merged as CG42230 in release 5.5 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

The gene is named "big bang" based on the fact that the gene is quite large, and mutants all appear to be mildly bang-sensitive.

(Kim et al., 2006)

Identification

External Crossreferences and Linkouts ( 96 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39583

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0087007

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0087007

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9598

Flygut - An atlas of the Drosophila adult midgut

FBgn0087007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39583

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42230

modMine - A data warehouse for the modENCODE project

FBgn0087007

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q15K23

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0087007

DRSC - Results frm RNAi screens

FBgn0087007

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0087007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9587-RA;CG9598-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0087007

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39583

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

BBG

(Kim et al., 2005.8.15)

C96

(Hall et al., 2004)

CG42230

(Bonnay et al., 2013, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

CG9587

(Dorus et al., 2006, Kim et al., 2006)

CG9598

(Sarov et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Peng et al., 2007, Kim et al., 2006)

bbg

(Haines and Eisen, 2018, Rajpurohit et al., 2018, Resnik-Docampo et al., 2017, Kockel et al., 2016, Duff et al., 2015, El Chamy et al., 2015, Gene Disruption Project members, 2015-, DeSalvo et al., 2014, Bonnay et al., 2013, Sen et al., 2013, Aranjuez et al., 2012, Fay et al., 2011, Wasbrough et al., 2010, FlyBase Curators, 2008-, Kim et al., 2006)

Name Synonyms

C96

CG9587

CG9598

big bang

(Bonnay et al., 2013, Aranjuez et al., 2012, Fay et al., 2011, Kim et al., 2006)

Secondary FlyBase IDs

FBgn0036425
FBgn0036424
FBgn0024488
FBan0009598

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (61)

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