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Gene Dmel\e(y)3

General Information
Symbol	Dmel\e(y)3	Species	D. melanogaster
Name	enhancer of yellow 3	Annotation symbol	CG12238
Feature type	protein_coding_gene	FlyBase ID	FBgn0087008
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	SAYP, l(1)G0084
Genomic Location
Chromosome (arm)	X	Recombination map	1-62.2
Cytogenetic map	18D8-18D11	Sequence location	X:19,520,581..19,532,402 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene enhancer of yellow 3 is referred to in FlyBase by the symbol Dmel\e(y)3 (CG12238, FBgn0087008). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: gene silencing; negative regulation of chromatin silencing; oogenesis; positive regulation of transcription, DNA-dependent; imaginal disc-derived leg morphogenesis; positive regulation of JAK-STAT cascade; negative regulation of transcription, DNA-dependent. 37 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; adult segment; anatomical structure; thoracic segment; adult; non-connected developing system; sense organ; embryonic hindgut. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Zinc finger, FYVE/PHD-type; Zinc finger, PHD-finger; Zinc finger, PHD-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1625117_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of e(y)3. Gene sequence location is X:19520581..19532402.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18D8-18D11   Limits computationally determined from genome sequence between P{EP}EP1348&P{EP}e(y)3EP1036 and P{EP}Sec61γEP1511
Experimentally Determined Cytological Location
Cytogenetic map Notes References 18D5-18D8   (determined by in situ hybridisation)   (Peter et al., 2002) 18D5-18D8   (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 18D5-18D8   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 18D5-18D8   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29) 18C-18D   (determined by in situ hybridisation)   (Georgiev and Gerasimova, 1989)
Experimentally Determined Recombination Data
Location	1-62.2 (Georgiev and Gerasimova, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\e(y)3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) e(y)3-RA FBtr0074762  NM_134490   6937   2006 e(y)3-RB FBtr0334278  NM_001272789   7784   2006 e(y)3-RC FBtr0334279  NM_001272790   7200   2012 e(y)3-RD FBtr0334280  NM_001272791   7718   2011 e(y)3-RE FBtr0334281  NM_001272792   6531   2006
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein e(y)3-PA   FBpp0074531   212.7   2006   7.54     NP_608334   AAF48990 e(y)3-PB   FBpp0306393   212.7   2006   7.54     NP_001259718   AGB95558 e(y)3-PC   FBpp0306394   213.3   2012   7.54     NP_001259719   AGB95559 e(y)3-PD   FBpp0306395   213.4   2011   7.54     NP_001259720   AGB95560 e(y)3-PE   FBpp0306396   212.7   2006   7.54     NP_001259721   AGB95561
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, PHD-type (IPR001965) Zinc finger, FYVE/PHD-type (IPR011011) Zinc finger, PHD-finger (IPR019787) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201173   AA246287   AA246693   AA263464   AA390758   AA391400   AA391517   AA391599   AA440070   AA441051   AA441353   AA539932   AA821152   AA942574   AE014298 AAF48990   AE014298 AGB95558   AE014298 AGB95559   AE014298 AGB95560   AE014298 AGB95561   AI405363   AI511841   AI512187   AI512653   AI514709   AI518475   AI518629   AI519278   AI533836   AI534970   AI541623   AI543718   AJ427000   AJ427002   AJ427003   AJ427004   AJ427005   AQ025376   AW942139   AY118323 AAM48352   BG636615   BG637631   BG638083   BG639027   BG639760   BH900864   BI352052   BI352683   BI353146   BI355204   BP546694   BT099689   BZ748868   CA804173   CK660292   CL528129   CO283904   CO284417   CO301547   CO324332   CO326648   CO333629   CZ482264   EC051256   EC074226   EC086253   EC086651   EC089225   EC215639   EC245827   EL878166   EL878167   EL878285   EL878412   EL878524   GH742259   GH942824   GH944675   GH949226   GH956476   GH958463   GH961319   GH962357   GH962598   GH962728   GH966070   GH966671   GH975211   GH975392   GH977856   GH980772   GH983728
UniProtKB/Swiss-Prot	Q9VWF2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
euchromatin inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) heterochromatin inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) nucleus inferred from direct assay (Shidlovskii et al., 2005) inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) PBAF complex inferred from physical interaction with brm, polybromo, mor, Bap170 (Chalkley et al., 2008) polytene chromosome inferred from direct assay (Chalkley et al., 2008, Nikolenko et al., 2005) inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105 Larval Midgut    50.3 Larval Hindgut    50.4 Larval Malpighian Tubules    38 Larval Fat Body    38 Larval Salivary Gland    56.6 Larval Trachea    170.2 Larval Carcass    59.075 Adult Head    41.5 Adult Eye    125.9 Adult Brain    99.2 Adult Thoracic-Abdominal Ganglion    74.9 Adult Crop    32.4 Adult Midgut    36.9 Adult Hindgut    39 Adult Malpighian Tubules    91.3 Adult Fat Body    28.4 Adult Salivary Gland    43 Adult Heart    66.5 Adult VirginFemale Spermatheca    81.1 Adult InseminatedFemale Spermatheca    84.9 Adult Ovary    158.1 Adult Testis    26.4 Adult Male Accessory Gland    39.1 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    125.9   NA  Brain    99.2   105  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    74.9   NA  Crop    no informative data   50.3  Midgut    no informative data   50.4  Hindgut    39   38  Malpighian Tubules    91.3   38  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    66.5   170.2  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    158.1   NA  Testis    26.4   NA  Male Accessory Gland    39.1   59.075  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (44) central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (87) ovary, mated 4-day female  (87) testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  (44) central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (87) ovary, mated 4-day female  (87) testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    44 central nervous system, pupae P8    19 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    87 ovary, mated 4-day female    87 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (86) embryo 04-06hr  (64) embryo 06-08hr  (72) embryo 08-10hr  (61) embryo 10-12hr  (34) embryo 12-14hr  (33) embryo 14-16hr  (43) embryo 16-18hr  (29) embryo 18-20hr    20 embryo 20-22hr  (28) embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day  (42) adult female 05day  (65) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (86) embryo 04-06hr  (64) embryo 06-08hr  (72) embryo 08-10hr  (61) embryo 10-12hr  (34) embryo 12-14hr  (33) embryo 14-16hr  (43) embryo 16-18hr  29 embryo 18-20hr    20 embryo 20-22hr  28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day  (42) adult female 05day  (65) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  113 embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    86 embryo 04-06hr    64 embryo 06-08hr    72 embryo 08-10hr    61 embryo 10-12hr    34 embryo 12-14hr    33 embryo 14-16hr    43 embryo 16-18hr    29 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    23 larva L1    15 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    42 adult female 05day    65 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  (28) embryonic 1182-4H  (31) embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1  (36) wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2    14 ovary fGS/OSS  (48) ovary OSC  (40) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  28 embryonic 1182-4H  31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1  (36) wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2    14 ovary fGS/OSS  (48) ovary OSC  (40) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    28 embryonic 1182-4H    31 embryonic GM2    18 embryonic Kc167    17 embryonic S1    22 embryonic S3    15 leg disc CME L1    36 wing disc CME-W2    11 wing disc ML-DmD8    22 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    14 ovary fGS/OSS    48 ovary OSC    40 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (28) cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (64) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (51) Caffeine 25 mg/ml 48 hrs, 4-day adult  (29) Paraquat 5 mM 48 hrs, 4-day adult  (42) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (64) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (51) Caffeine 25 mg/ml 48 hrs, 4-day adult  29 Paraquat 5 mM 48 hrs, 4-day adult  (42) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    42 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD10287 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0087008 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for e(y)3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal e(y)3EMSl lethal | embryonic stage | recessive e(y)3EMSl lethal | partially | recessive e(y)31 e(y)32 e(y)33 lethal | pharate adult stage e(y)3G0381 e(y)3G0409 lethal | pupal stage e(y)3G0084 e(y)3G0266 e(y)3G0283 e(y)3G0409 lethal | recessive e(y)3G0084 e(y)3G0266 e(y)3G0283 e(y)3G0381 e(y)3G0409 e(y)3PG143 partially lethal - majority die | male limited e(y)34 partially lethal - majority live e(y)34 viable e(y)34 e(y)3CC01368 e(y)3EY08767 viable, with Scer\GAL4pnr-MD237 e(y)3GD7544 viable | reduced e(y)34 Sterility Allele female sterile e(y)34 female sterile | recessive e(y)31 e(y)32 e(y)33 e(y)34 fertile e(y)3EY08767 Other Phenotypes Allele cell cycle defective e(y)34 neuroanatomy defective e(y)3dsRNA.cIa non-suppressor of variegation, with P{hsp26-pt-T}118E-3 e(y)34 small body e(y)34 suppressor of variegation e(y)34 e(y)3ΔPHD suppressor of variegation, with In(1)wm4h e(y)34 suppressor of variegation, with P{hsp26-pt-T}39C-12 e(y)34 suppressor of variegation, with P{hsp26-pt-T}39C-42 e(y)34 suppressor of variegation, with P{hsp26-pt-T}39C-52 e(y)34 suppressor of variegation, with P{hsp26-pt-T}118E-10 e(y)34 suppressor of variegation, with P{hsp26-pt-T}118E-19 e(y)34 suppressor of variegation, with P{hsp26-pt-T}118E-25 e(y)34 visible e(y)34 visible, with Scer\GAL4pnr-MD237 e(y)3GD7544 visible | recessive e(y)31 e(y)32 e(y)33 Phenotype manifest in Allele adult head e(y)34 embryonic/larval midgut e(y)3EMSl embryonic/larval midgut primordium e(y)3EMSl embryonic head e(y)3EMSl embryonic Malpighian tubule e(y)3EMSl femur e(y)34 femur | male limited e(y)34 gonad | embryonic stage e(y)3EMSl leg e(y)34 macrochaeta e(y)31 e(y)32 e(y)33 e(y)34 mesothoracic tergum, with Scer\GAL4pnr-MD237 e(y)3GD7544 ventral nerve cord commissure e(y)3dsRNA.cIa wing e(y)34
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of e(y)3 Class Mutagen Stocks Known lesion e(y)3G0381 P-element activity 2 -- e(y)3G0409 P-element activity 2 -- e(y)3CB-5689-3 1 -- e(y)3CB-5736-3 1 -- e(y)3e04514 piggyBac transposase 1 -- e(y)3EY02011 P-element activity 1 -- e(y)3EY08767 P-element activity 1 -- e(y)3G0084 P-element activity 1 -- e(y)3G0266 P-element activity 1 -- e(y)3G0283 P-element activity 1 -- e(y)3KG01940 P-element activity 1 -- e(y)3NP0968 1 -- e(y)3NP1003 1 -- e(y)31 PM hybrid dysgenesis 0 Yes e(y)32 PM hybrid dysgenesis 0 Yes e(y)33 PM hybrid dysgenesis 0 Yes e(y)34 Stalker-hybrid dysgenesis 0 Yes e(y)3CB-6344-3 0 -- e(y)3CC01368 P-element activity 0 Yes e(y)3EMSl ethyl methanesulfonate 0 Yes e(y)3EP1036 P-element activity 0 -- e(y)3G0135b P-element activity 0 -- e(y)3GG01163 0 -- e(y)3GG01276 0 -- e(y)3NP4118 0 -- e(y)3PG143 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of e(y)3 Class Mutagen Stocks Known lesion e(y)3GD7544 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes e(y)3HMS00337 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes e(y)3KK112108 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes e(y)3+tSa in vitro construct - genomic fragment 0 Yes e(y)3dsRNA.cIa in vitro construct - RNAi 0 Yes e(y)3GD16966 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes e(y)3NIG.12238R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes e(y)3t18D-5A in vitro construct 0 Yes e(y)3t18D-5B in vitro construct 0 Yes e(y)3T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes e(y)3ΔPHD in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC364 (Popodi et al., 2010-, Venken et al., 2010) Dp(1;3)DC365 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7544} NA P{GD16966} NA P{KK112108} NA P{NIG.12238R} NA P{TRiP.HMS00337} NA characterization construct P{e(y)3} NA P{e(y)3ΔPHD} NA P{FLAG-e(y)3+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}e(y)3EP1036 NA P{EPgy2}e(y)3EY02011 NA P{EPgy2}e(y)3EY08767 NA P{Mae-UAS.6.11}e(y)3GG01163 NA P{Mae-UAS.6.11}e(y)3GG01276 NA miscellaneous insertions P{}e(y)31 NA P{}e(y)32 NA P{}e(y)33 NA P{PTT-GC}e(y)3CC01368 NA P{RS3}e(y)3CB-5689-3 NA P{RS3}e(y)3CB-5736-3 NA P{RS3}e(y)3CB-6344-3 NA P{SUPor-P}e(y)3KG01940 NA PBac{RB}e(y)3e04514 NA Stalker{}e(y)34 NA insertion of enhancer trap binary system P{GawB}e(y)3NP0968 No P{GawB}e(y)3NP1003 No P{GawB}e(y)3NP4118 No P{GawB}e(y)3PG143 No insertion of enhancer trap P{lacW}e(y)3G0084 No P{lacW}e(y)3G0135b No P{lacW}e(y)3G0266 No P{lacW}e(y)3G0283 No P{lacW}e(y)3G0381 No P{lacW}e(y)3G0409 No P{lacW}l(1)G0285G0285 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005)
Biological Process
CV term Evidence References
gene silencing inferred from mutant phenotype (assigned by UniProtKB) (Shidlovskii et al., 2005) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Chalkley et al., 2008) negative regulation of chromatin silencing inferred from genetic interaction with Pc (Chalkley et al., 2008) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (assigned by UniProtKB) (Shidlovskii et al., 2005) oogenesis inferred from mutant phenotype (assigned by UniProtKB) (Shidlovskii et al., 2005) positive regulation of JAK-STAT cascade inferred from mutant phenotype (Muller et al., 2005) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (assigned by UniProtKB) (Shidlovskii et al., 2005)
Cellular Component
CV term Evidence References
euchromatin inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) heterochromatin inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) nucleus inferred from direct assay (Shidlovskii et al., 2005) inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005) PBAF complex inferred from physical interaction with brm, polybromo, mor, Bap170 (Chalkley et al., 2008) polytene chromosome inferred from direct assay (Chalkley et al., 2008, Nikolenko et al., 2005) inferred from direct assay (assigned by UniProtKB) (Shidlovskii et al., 2005)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001965 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
e(y)3 - Stat92E anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, molecular sieving (Panov et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions e(y)3 allele Gene References e(y)31 y (Georgiev and Gerasimova, 1989) e(y)32 y (Georgiev and Gerasimova, 1989) e(y)33 y (Georgiev and Gerasimova, 1989) e(y)34 ct (Melnikova et al., 1996) e(y)1 (Soldatov et al., 1999) sc (Gause et al., 1996) y (Georgiev and Gerasimova, 1989, Shidlovskii et al., 2005) z (Georgiev, 1994) unspecified w (Georgiev, 1994)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59261 DroID - A comprehensive database of gene and protein interactions. • FBgn0087008 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32965
Orthologs
OrthoDB Orthologs (136) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BRX4Z Dipteran inclusive ortholog search EOG6GXFVN Insect inclusive ortholog search EOG6547TC Arthropod inclusive ortholog search EOG64XGXK Metazoa inclusive ortholog search EOG6RZ9RS
Orthologs in Drosophila Species (EOG6BRX4Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\e(y)3     Drosophila melanogaster fruit fly  Dmel\CG32676     Drosophila melanogaster fruit fly  Dmel\dac     Drosophila melanogaster fruit fly  Dmel\tyf     Drosophila melanogaster fruit fly  Dmel\Cpr64Ad     Drosophila melanogaster fruit fly  Dmel\CG10915     Drosophila melanogaster fruit fly  Dmel\RhoGAP19D     Drosophila melanogaster fruit fly  Dmel\CG43349     Drosophila melanogaster fruit fly  Dmel\dp     Drosophila melanogaster fruit fly  Dmel\CG32603     Drosophila melanogaster fruit fly  Dmel\nocte     Drosophila melanogaster fruit fly  Dmel\elav     Drosophila melanogaster fruit fly  Dmel\CG7300     Drosophila melanogaster fruit fly  Dmel\NFAT     Drosophila melanogaster fruit fly  Dmel\bif     Drosophila melanogaster fruit fly  Dmel\Aef1     Drosophila melanogaster fruit fly  Dmel\CG16711     Drosophila melanogaster fruit fly  Dmel\Vsx1     Drosophila melanogaster fruit fly  Dmel\sbb     Drosophila melanogaster fruit fly  Dmel\CG30069     Drosophila melanogaster fruit fly  Dmel\sens-2     Drosophila melanogaster fruit fly  Dmel\CG8157     Drosophila melanogaster fruit fly  Dmel\Muc12Ea     Drosophila melanogaster fruit fly  Dmel\Samuel     Drosophila melanogaster fruit fly  Dmel\CG15894     Drosophila melanogaster fruit fly  Dmel\CG32767     Drosophila simulans   Dsim\GD22700   Y Drosophila erecta   Dere\GG24368   Y Drosophila yakuba   Dyak\GE14706   Y Drosophila ananassae   Dana\GF23960   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA26108   Y Drosophila persimilis   Dper\GL14154   Y Drosophila virilis   Dvir\GJ17387   Y Drosophila mojavensis   Dmoj\GI17886   Y Drosophila grimshawi   Dgri\GH13743   Y
Orthologs in non-Drosophila Dipterans (EOG6GXFVN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012909 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000819 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012905 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009265 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010021 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010024 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013285 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005058 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004536 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012484 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015316 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007969 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002709 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007483 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015312 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015311 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006893 Y
Orthologs in non-Dipteran Insects (EOG6547TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41255 Y Apis mellifera Western honey bee  Amel\GB43208 Y Apis mellifera Western honey bee  Amel\GB43666 Y Apis mellifera Western honey bee  Amel\CPR2 Y Apis mellifera Western honey bee  Amel\GB52999 Y Apis mellifera Western honey bee  Amel\LOC551587 Y Apis mellifera Western honey bee  Amel\GB55781 Y Apis mellifera Western honey bee  Amel\GB42621 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004953 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036228 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008772 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004406 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000786 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006740 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG035759 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009060 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG034456 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013086 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027795 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG032807 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008673 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016473 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004397 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005049 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001062 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004225 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008627 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG029848 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014054 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008994 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007076 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14778 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14777 Y Atta cephalotes Leafcutter ant  Acep\ACEP23948 Y Atta cephalotes Leafcutter ant  Acep\ACEP23943 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16689 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12372 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12371 Y Linepithema humile Argentine ant  Lhum\LH24821 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25725 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27161 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27158 Y Solenopsis invicta Red fire ant  Sinv\SINV24596 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI060717 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001358 Y Bombyx mori Silkmoth  Bmor\CPG33 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003481 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011157 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006856 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007313 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010134 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002715 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001620 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012308 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005012 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014578 Y Tribolium castaneum Red flour beetle  Tcas\TC011986 Y Tribolium castaneum Red flour beetle  Tcas\TC009709 Y Tribolium castaneum Red flour beetle  Tcas\Ubx Y Tribolium castaneum Red flour beetle  Tcas\TC011154 Y Tribolium castaneum Red flour beetle  Tcas\TC013169 Y
Orthologs in non-Insect Arthropods (EOG64XGXK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\petN Y Daphnia pulex Water flea  Dpux\JGI_V11_332869 Y Ixodes scapularis Deer tick  Isca\ISCW020313 Y
Orthologs in non-Arthropod Metazoa (EOG6RZ9RS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014572gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026550gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006001gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006000gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016681gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004895gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024374gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015008gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020905gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018275gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019854gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016807gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026651gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021044gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027006gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004845gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016555gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026649gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021866gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020968gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	14581 y1 P{SUPor-P}e(y)3KG01940 10270 w67c23 P{lacW}e(y)3G0283/FM7c 11807 w67c23 P{lacW}e(y)3G0084/FM7c 11897 w67c23 P{lacW}e(y)3G0266/FM7c 11910 w67c23 P{lacW}e(y)3G0409/FM7c 11996 w67c23 P{lacW}e(y)3G0381/FM7c
Harvard	- PBac{RB}e(y)3e04514
Kyoto	123758 w1118 P{RS3}e(y)3CB-5689-3 123786 w1118 P{RS3}e(y)3CB-5736-3
VDRC	v105946 P{KK112108}VIE-260B v38637 w1118; P{GD7544}v38637 v38638 w1118; P{GD7544}v38638
	More stocks available...
Genomic Clones ( 2 )
	BACR10M08 BACR33M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 70 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10526 LD27440
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25340 GM17364 GM20366 GM22464 GM29926 LD03881 LD05074 LD05611 LD07293 LD08842 LD10287 LD10646 LD15823 LD16254 LD19234 LD26880 LD38003 LD38248 LD38804 LD41205 LD41940 LD43379 LD43944 LD44579 LP18736 SD01274 SD05806 SD10602 SD14361
Other clones	54162 58339 65826 72944 157941 167446 EC051256 EK164757 EK166015 EK181362 EK193243 EK307507 EP04361 ESG0112b.B21_G05 FGH109B04 GM14710 IP08065 IP08165 IP08265 IP08365 LD15151 RP001012058 RP004032663 RP004077457 RP004187247 RP004206123 RP004237584 RP004238669 RP004254379 RP004275820 RP004343829 RP004348155 RP004477368 RP004483766 RP004521926 RP004524154 RP004525883 RP004536560 SD05644
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0087008 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32965
Antibody Information
	polyclonal (Shidlovskii et al., 2005, Chalkley et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(1)G0084 CG12238 l(1)G0409 l(1)G0381 l(1)G0266 l(1)G0283 (Peter et al., 2002) Source for merge of: l(1)G0084 e(y)3 (Shidlovskii et al., 2005)
Additional comments	"l(1)G0285" may affect "CG12238". (Peter et al., 2002)
Other Comments
	The effect of mutations in the e(y)3 locus on mutagenesis in the y2ns scme double superunstable system has been analysed. (Elagin et al., 1994) Mutations at the e(y)3 loci enhance the phenotypic expression of several insertion mutations of y without exerting any effect on mdg4 induced mutations at other loci. One mutation in e(y)3 is due to insertion of a Stalker element. (Georgiev et al., 1990) Modifies the expression of y2, a gypsy-induced allele, but not other gypsy-induced mutations. The effects of all e(y) alleles on bristle color persist in the presence of su(Hw)2. No effect on the phenotype of y+
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134490 NM_001272789 NM_001272790 NM_001272791 NM_001272792 RefSeq (Proteins) • NP_608334 NP_001259718 NP_001259719 NP_001259720 NP_001259721 DDBJ / EMBL / GenBank • AA391400 AA391517 AAF48990 AAM48352 AGB95558 AGB95559 AGB95560 AGB95561 AJ427000 AJ427002 AJ427003 AJ427004 AJ427005 AQ025376 AW942139 AY118323 BH900864 BZ748868 CL528129 CZ482264 Entrez Gene - A searchable database of RefSeq genes. • 32965 UniProtKB/Swiss-Prot • Q9VWF2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, PHD-type (IPR001965) Zinc finger, FYVE/PHD-type (IPR011011) Zinc finger, PHD-finger (IPR019787) Zinc finger, RING/FYVE/PHD-type (IPR013083) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD10287
Linkouts
	BioGRID - A database of protein and genetic interactions • 59261 DroID - A comprehensive database of gene and protein interactions. • FBgn0087008 DRSC - Results from RNAi screens. • FBgn0087008 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0087008 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0087008 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32965 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32965 modMine - Data generated by the modENCODE project. • FBgn0087008
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG12238 (Ivanov et al., 2004, Oh et al., 2004, Michaut et al., 2003, Bourbon et al., 2002, Bienz, 2006, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Shidlovskii et al., 2005) e(y)3 (Bienz, 2006, Vorobyeva et al., 2009, Abramov et al., 2011, Toku et al., 2011, Baig et al., 2010, Popodi et al., 2010-, Vorobyeva et al., 2009, Shidlovskii et al., 2005, Nikolenko et al., 2005, Vorobyeva et al., 2008, Kuzmina et al., 2010, Venken et al., 2010) e(y)3 (Georgiev et al., 1990) l(1)G0084 (Muller et al., 2005, Peter et al., 2002, Schaefer et al., 1999.3.29, Buszczak et al., 2007, McGraw et al., 2008, Straub et al., 2008, Japanese National Institute of Genetics, 2012.5.21) l(1)G0266 (Schaefer et al., 1999.6.15, ) l(1)G0283   l(1)G0381 (Schaefer et al., 1999.8.12, ) l(1)G0409   SAYP (Bienz, 2006, Vorobyeva et al., 2009, Vorobyeva et al., 2011, Vorobyeva et al., 2009, Shidlovskii et al., 2005, Nikolenko et al., 2005, Soshnikova et al., 2008, Vorobyeva et al., 2008, Moshkin et al., 2012, Kuzmina et al., 2010) sayp (Chalkley et al., 2008)
Name Synonym	enhancer of yellow 3 (McGraw et al., 2008, Baig et al., 2010) lethal (1) G0084   Supporter of Activation of Yellow Protein (Shidlovskii et al., 2005, Vorobyeva et al., 2009, Shidlovskii et al., 2005) supporter of activation of yellow protein (Soshnikova et al., 2008)
Secondary FlyBase IDs
	FBgn0000619 FBgn0026680 FBgn0027204 FBgn0027235 FBgn0027245 FBgn0028301 FBgn0031046
References ( 62 )
Generate a list of	All references relating to this gene ( 62 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 6 )
	Moshkin et al., 2012, Mol. Cell. Biol. 32(3): 675--688 Remodelers Organize Cellular Chromatin by Counteracting Intrinsic Histone-DNA Sequence Preferences in a Class-Specific Manner. [FBrf0217223] Panov et al., 2012, Nucleic Acids Res. 40(6): 2445--2453 Transcription co-activator SAYP mediates the action of STAT activator. [FBrf0218425] Vorobyeva et al., 2012, Nucleic Acids Res. 40(15): 7319--7331 SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing. [FBrf0219302] Abramov et al., 2011, Dokl. Biochem. Biophys. 437(1): 72--76 Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster. [FBrf0213780] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vorobyeva et al., 2011, Cell Cycle 10(11): 1821--1827 SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. [FBrf0213948] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...