5-HT2, 5-HT2Dro, 5-HT2, 5HT2Dro, 5HT2a
seven-pass transmembrane protein - coordinates germband extension movements
Please see the JBrowse view of Dmel\5-HT2A for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Gene model reviewed during 5.49
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
3.9 (compiled cDNA)
None of the polypeptides share 100% sequence identity.
868 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\5-HT2A using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
5-HT2A is expressed in seven stripes in the blastoderm embryo. The first two and last two stripes are stronger than the middle three. Expression remains detectable through gastrulation with expression weaker in the 4th and 5th stripes. Expression fades during germ band extension.
5-HT2 transcripts are present in embryos, larvae, and adults with a peak in 3-6hr embryos. They are first detected by in situ hybridization in cellular blastoderm embryos in even pair-rule stripes which persist through germ band extension. They are later seen in a pair of cells per neuromere in the CNS starting at stage 13.
JBrowse - Visual display of RNA-Seq signals
View Dmel\5-HT2A in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
Serotinin, acting through the 5-HT2 gene product, is necessary for proper gastrulation.
Deletion of 5-HT2 is associated with a specific, double-line cuticular phenotype.
Peaks of 5-HT2 expression and serotonin synthesis coincide precisely with the onset of convergent extension of the ectoderm.
Mutants do not extend the germband properly, and ectodermal movements become asynchronous with the morphogenetic movements in the endoderm and mesoderm. Adherens junctions in the ectoderm show altered subcellular distribution at the onset of the asynchronicity.
Identified in a screen for genes encoding G-protein coupled receptors.
This serotonin receptor displays a sequence, gene organisation and pharmacology typical of the mammalian serotonin 5-HT2 receptor type (5-HT2B subtype) acting on phospholipase C.
Source for merge of: 5-HT2 l(3)82CDb
Source for identity of: 5-HT2A 5-HT2
