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Gene Dmel\5-HT2

General Information
Symbol	Dmel\5-HT2	Species	D. melanogaster
Name	Serotonin receptor 2	Annotation symbol	CG1056
Feature type	protein_coding_gene	FlyBase ID	FBgn0087012
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	5-HT2Dro, 5-HT2, 5-HT2Dro, 5HT2Dro, 5-HT2Dro
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	82C3-82D5	Sequence location	3R:438,597..459,026 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serotonin receptor 2 is referred to in FlyBase by the symbol Dmel\5-HT2 (CG1056, FBgn0087012). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity. There is experimental evidence that it is involved in the biological process: germ-band extension. 16 alleles are reported. The phenotypes of these alleles are annotated with: gastrula embryo; extended germ band embryo; pole cell; embryonic epidermis; ventral midline; denticle belt. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1633198_a_at completely aligns to an exonic region of only a subset of 4 of the 5 FlyBase-annotated transcript isoforms of 5-HT2. Gene sequence location is 3R:438597..459026.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Johnson et al., 2011, Neuroscience 192: 372--381
FB2012_01	Insertions Mi{MIC}5-HT2[MI03299] Alleles 5-HT2[MI03299] Sequence features HFA11990 BKN30704 References Bellen, 2011.11.10, set958.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82C3-82D5   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974; Left limit from inclusion within Df(3R)110 (FBrf0104943) Right limit from non-inclusion within Df(3R)6-7 (FBrf0104943)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82C-82C     (Maroteaux, 1995.3.14) 82C-82E     (Colas et al., 1999) 82C-82D   (determined by in situ hybridisation)   (Maroteaux, 1995.5.31)
Experimentally Determined Recombination Data
Location	3- (Maroteaux, 1995.3.14)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\5-HT2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone HL07802 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) 5-HT2-RA FBtr0078854  NM_079499   4350   868 5-HT2-RB FBtr0078855  NM_169011   3717   930 5-HT2-RC FBtr0112871  NM_001104214   4311   855 5-HT2-RD FBtr0300474  NM_001170034   3173   638 5-HT2-RE FBtr0301885  NM_001170035   3881   868
Additional Transcript Data & Comments
Reported size (kB)	3.9 (compiled cDNA) (Colas et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein 5-HT2-PA   FBpp0078494   95.1   868   8.90     NP_524223   AAF52113 5-HT2-PB   FBpp0078495   101.6   930   8.82     NP_730859   AAN13284 5-HT2-PC   FBpp0111784   93.6   855   8.76     NP_001097684   ABW08600 5-HT2-PD   FBpp0289701   70.1   638   6.93     NP_001163505   ACZ94804 5-HT2-PE   FBpp0291099   95.1   868   8.90     NP_001163506   ACZ94805
Additional Polypeptide Data & Comments
Reported size (kDa)	868 (aa) (Colas et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) GPCR, rhodopsin-like superfamily (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699149   AE014297 AAF52113   AE014297 AAN13284   AE014297 ABW08600   AE014297 ACZ94804   AE014297 ACZ94805   AW942018   AY061039 AAL28587   BI363452   BI570663   BI571884   BI641207   BT015194 AAT94423   BT066316   CO177669   CO189293   CO190936   CO267413   CO272394   CO281019   CO285887   CO285995   CO305028   CO311436   CO318227   CO326776   CZ468968   CZ470073   CZ479170   CZ479171   CZ490214   DD177562   EC053283   EC055536   EC056114   EC056365   EC056594   EC073129   EC081294   EC084591   EC086853   EC194818   EC207125   EC217657   EC225332   EC230003   GH746600   X81835 CAA57429   X85407
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24511 Q6AWQ4 Q8IPN2 Q95RY6 Q9VN38 A8JQT4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   organism | even pair rule expression pattern   (Colas et al., 1995) embryonic stage 13 -- 17   central nervous system | restricted   (Colas et al., 1995)
Additional Descriptive Data
	5-HT2 transcripts are present in embryos, larvae, and adults with a peak in 3-6hr embryos. They are first detected by in situ hybridization in cellular blastoderm embryos in even pair-rule stripes which persist through germ band extension. They are later seen in a pair of cells per neuromere in the CNS starting at stage 13. (Colas et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0087012    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0087012 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0087012 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr  (161) embryo 04-06hr  (249) embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr  (117) pupae 2d postWPP  (182) pupae 3d postWPP    91 pupae 4d postWPP  (474) adult male 01day  (314) adult male 05day  (331) adult male 30day  (291) adult female 01day  (183) adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0087012 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr  (161) embryo 04-06hr  (249) embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr  117 pupae 2d postWPP  (182) pupae 3d postWPP    91 pupae 4d postWPP  (474) adult male 01day  (314) adult male 05day  (331) adult male 30day  (291) adult female 01day  (183) adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    161 embryo 04-06hr    249 embryo 06-08hr    83 embryo 08-10hr    57 embryo 10-12hr    48 embryo 12-14hr    39 embryo 14-16hr    41 embryo 16-18hr    46 embryo 18-20hr    54 embryo 20-22hr    83 embryo 22-24hr    97 larva L1    75 larva L2    34 larva L3 12hr old    15 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    33 white prepupae new    43 white prepupae 12hr    93 white prepupae 24hr    117 pupae 2d postWPP    182 pupae 3d postWPP    91 pupae 4d postWPP    474 adult male 01day    314 adult male 05day    331 adult male 30day    291 adult female 01day    183 adult female 05day    61 adult female 30day    55 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0087012    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0087012 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0087012 expression level Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland    1659.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye  (587.6) Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland  (1659.6) Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland  (1659.6) Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland    1659.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0087012 expression level Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland    1659.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye  587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland  (1659.6) Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland  1659.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    13 Larval Midgut    9.1 Larval Hindgut    6 Larval Malpighian Tubules    2.7 Larval Fat Body    9.9 Larval Salivary Gland    25.6 Larval Trachea no informative data Larval Carcass    3.075 Adult Head    156.9 Adult Eye    587.6 Adult Brain    93.2 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    29.4 Adult Midgut    9.1 Adult Hindgut    14.7 Adult Malpighian Tubules    2.1 Adult Fat Body    7.4 Adult Salivary Gland    1659.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    7 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    1.1 Adult Testis    33.5 Adult Male Accessory Gland    103.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    156.9   NA  Eye    587.6   NA  Brain    93.2   13  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    31   NA  Crop    29.4   9.1  Midgut    9.1   6  Hindgut    14.7   2.7  Malpighian Tubules    2.1   9.9  Fat Body    7.4   25.6  Salivary Gland    1659.6   NA  Heart    15.275   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    7   NA  InseminatedFemale Spermatheca    6.9   NA  Ovary    1.1   NA  Testis    33.5   NA  Male Accessory Gland    103.5   3.075  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0087012 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for 5-HT2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dominant | heat sensitive 5-HT2hs.PC lethal | embryonic stage (with Df(3R)HTRI) 5-HT2C1644 lethal | embryonic stage | recessive 5-HT2C1644 5-HT2M51 lethal | first instar larval stage | recessive 5-HT2C1644 lethal | heat sensitive 5-HT2a.Y32.hs lethal | recessive 5-HT2C1644 viable 5-HT2PL00052 viable, with Scer\GAL4Kr.PM 5-HT2Scer\UAS.cCa viable (with Df(3R)HTR6) 5-HT2C1644 viable | poor | heat sensitive, with Scer\GAL4Kr.PM 5-HT2Scer\UAS.cCa Sterility Allele fertile 5-HT2PL00052 Phenotype manifest in Allele denticle belt 5-HT2C1644 embryonic epidermis 5-HT2hs.PC extended germ band embryo 5-HT2a.Y32.hs gastrula embryo, with Scer\GAL4Kr.PM 5-HT2Scer\UAS.cCa pole cell 5-HT2a.Y32.hs ventral midline 5-HT2a.Y32.hs
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of 5-HT2 Class Mutagen Stocks Known lesion 5-HT2c04028 piggyBac transposase 1 -- 5-HT2C1644 gain of function allele 1 Yes 5-HT2e01363 loss of function allele piggyBac transposase 1 Yes 5-HT2f07458 piggyBac transposase 1 -- 5-HT2MI00459 1 -- 5-HT2PL00052 P-element activity 1 Yes 5-HT2c05529 piggyBac transposase 0 -- 5-HT2M51 0 -- 5-HT2MI03299 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of 5-HT2 Class Mutagen Stocks Known lesion 5-HT2a.Y32.hs in vitro construct - regulatory fusion 1 Yes 5-HT2DCIII.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 1 Yes 5-HT2JF02157 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 5-HT2KK110704 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 5-HT2Scer\UAS.cCa in vitro construct - regulatory fusion 1 Yes 5-HT2GD664 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes 5-HT2hs.PC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)110 (Colas et al., 1999, Colas et al., 1995, Megraw and Kaufman, 1998.10.2, Schaerlinger et al., 2007) Df(3R)HTRE (Colas et al., 1999) Df(3R)HTRI (Colas et al., 1999, Colas et al., 1999, Schaerlinger et al., 2007) Df(3R)Z1 (Megraw and Kaufman, 1998.10.2)
Not disrupted in	Df(3R)3-4 (Megraw and Kaufman, 1998.10.2) Df(3R)6-7 (Colas et al., 1995, Megraw and Kaufman, 1998.10.2, Schaerlinger et al., 2007) Df(3R)107 (Megraw and Kaufman, 1998.10.2) Df(3R)HTR6 (Colas et al., 1999, Colas et al., 1999, Schaerlinger et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD664} NA P{KK110704} NA P{TRiP.JF02157} NA P{UAS-5-HT2.C} NA P{UAS-5-HT2.DCIII} NA heat-shock construct P{hs-5-HT2.C} NA P{hs-5-HT2.Y32.a} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}5-HT2MI00459 NA Mi{MIC}5-HT2MI03299 NA P{UAST-YFP.RabX6.S22N}02 NA PBac{PB}5-HT2c04028 NA PBac{PB}5-HT2c05529 NA PBac{RB}5-HT2e01363 NA PBac{WH}5-HT2f07458 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}5-HT2PL00052 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
germ-band extension inferred from mutant phenotype (Colas et al., 1999)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay AND inferred from sequence or structural similarity (Colas et al., 1995)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
G-protein coupled amine receptor activity inferred from sequence or structural similarity (Radford et al., 2002) Gq/11-coupled serotonin receptor activity non-traceable author statement (Tierney, 2001) serotonin receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) non-traceable author statement (Maroteaux, 1995.3.14) traceable author statement (Tierney, 2001)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276 (FlyBase Curators et al., 2004-) serotonin receptor signaling pathway inferred from sequence or structural similarity (Brody and Cravchik, 2000) non-traceable author statement (Maroteaux, 1995.3.14) traceable author statement (Tierney, 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000276 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000) plasma membrane non-traceable author statement (Maroteaux, 1995.3.14)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions 5-HT2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65794 DroID - A comprehensive database of gene and protein interactions. • FBgn0087012 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40575
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmau\5-HT2 (Zeng et al., 2000) Dpse\GA10393   Dsim\5-HT2 (Zeng et al., 2000)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002232-PA Anopheles gambiae (mosquito) XP_001947553.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000017943 Bos taurus (bovine) CBP03892 Caenorhabditis briggsae (nematode) ENSCAFP00000026933 Canis familiaris (dog) ENSCINP00000001494 Ciona intestinalis (sea squirt) JA00148 Caenorhabditis japonica (nematode) ENSCPOP00000000132 Cavia porcellus (guinea pig) RP02425 Caenorhabditis remanei (nematode) 141683 Capitella spl (polychaete worm) ENSDARP00000075409 Danio rerio (zebra fish) ENSECAP00000018999 Equus caballus (horse) ENSGALP00000027400 Gallus gallus (chicken) ENSP00000276198 Homo sapiens (human) 82265 Lottia gigantea (owl limpet) ENSMODP00000014108 Monodelphis domestica (gray opossum) ENSMMUP00000012572 Macaca mulatta (rhesus monkey) ENSMUSP00000043936 Mus musculus (house mouse) XP_001607771.1 Nasonia vitripennis (wasp) ENSOANP00000024516 Ornithorynchus anatinus (platypus) ENSORLP00000010602 Oryzias latipes (japanese killifish) PHUM000364-PA Pediculus humanus (human body louse) PP14182 Pristionchus pacificus (nematode) ENSPPYP00000023110 Pongo pygmaeus (orangutan) ENSPTRP00000038211 Pan troglodytes (chimpanzee) ENSRNOP00000013408 Rattus norvegicus (norway rat) ENSTRUP00000044601 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021042 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10792 LH20553 FBgn0242495 FBgn0215836 FBgn0209760 FBgn0191229 FBgn0165711 JGI_V11_7660 JGI_V11_8518 FBgn0070450 FBgn0159662 FBgn0147313 FBgn0125559 FBgn0104772 FBgn0093683 CPIJ011883 ACYPI008969 ACYPI007093 GB18151 GPR5HT2A GPR5HT2 PHUM220540 GLEAN_13979 GLEAN_13980
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	24504 w1118; P{UAS-5-HT2.C}2 24505 w1118; P{hs-5-HT2.Y32.a}2 24506 w1118; P{UAS-5-HT2.DCIII}2 31882 y1 v1; P{TRiP.JF02157}attP2 4830 5-HT2C1644 kar1 ry506/TM3, Sb1 31012 y1 w*; Mi{MIC}5-HT2MI00459/TM6B, Tb1 19367 w*; P{FRT(whs)}2A P{neoFRT}82B PBac{GAL4D,EYFP}5-HT2PL00052
Harvard	- PBac{PB}5-HT2c04028 - PBac{RB}5-HT2e01363 - PBac{WH}5-HT2f07458
VDRC	v102105 P{KK110704}VIE-260B
Genomic Clones ( 1 )
	BACR07E06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL07802 RH04788
Other clones	MIP06036
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE48265 RH05432 RH07190
Other clones	37491 37546 76140 102821 CK01.22A.H1 CK01.62B.G10 CK01.66D.F5 CK01.79A.E3 EC053283 EC055536 EC056114 EC056365 EC056594 EK043822 EK050144 EK054023 EK061106 EK061418 EK107008 EK150053 EK155738 EK224546 EK247102 EK271111 EP04618 RP001017147 SD24424
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0087012 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40575 46794
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: 5-HT2 l(3)82CDb (Schaerlinger et al., 2007)
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Peaks of 5-HT2 expression and serotonin synthesis coincide precisely with the onset of convergent extension of the ectoderm. (Colas et al., 1999) Mutants do not extend the germband properly, and ectodermal movements become asynchronous with the morphogenetic movements in the endoderm and mesoderm. Adherens junctions in the ectoderm show altered subcellular distribution at the onset of the asynchronicity. (Colas et al., 1999) Serotinin, acting through the 5-HT2 gene product, is necessary for proper gastrulation. (Colas et al., 1999) Deletion of 5-HT2 is associated with a specific, double-line cuticular phenotype. (Colas et al., 1999) Identified in a screen for genes encoding G-protein coupled receptors. (Colas et al., 1995) Characterisation of 5-HT2 reveals it is expressed in the central nervous system during larval and adult stages and the receptor is expressed at the blastoderm stage in a pattern similar to that of ftz. (Colas et al., 1995) This serotonin receptor displays a sequence, gene organisation and pharmacology typical of the mammalian serotonin 5-HT2 receptor type (5-HT2B subtype) acting on phospholipase C. (Maroteaux, 1995.5.31)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079499 NM_169011 NM_001104214 NM_001170034 NM_001170035 RefSeq (Proteins) • NP_524223 NP_730859 NP_001097684 NP_001163505 NP_001163506 DDBJ / EMBL / GenBank • AA699149 AAF52113 AAL28587 AAN13284 AAT94423 ABW08600 ACZ94804 ACZ94805 AW942018 AY061039 BT015194 CAA57429 CZ468968 CZ470073 CZ479170 CZ479171 CZ490214 DD177562 X81835 X85407 Entrez Gene - A searchable database of RefSeq genes. • 40575 UniProtKB/TrEMBL • A8JQT4 Q6AWQ4 Q8IPN2 Q9VN38 Q95RY6 Q24511
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) GPCR, rhodopsin-like superfamily (IPR017452)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65794 DroID - A comprehensive database of gene and protein interactions. • FBgn0087012 DRSC - Results from RNAi screens. • FBgn0087012 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0087012 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0087012 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40575 46794 InParanoid A subset of ortholog calls from InParanoid. • AGAP002232-PA Anopheles gambiae (mosquito) XP_001947553.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000017943 Bos taurus (bovine) CBP03892 Caenorhabditis briggsae (nematode) ENSCAFP00000026933 Canis familiaris (dog) ENSCINP00000001494 Ciona intestinalis (sea squirt) JA00148 Caenorhabditis japonica (nematode) ENSCPOP00000000132 Cavia porcellus (guinea pig) RP02425 Caenorhabditis remanei (nematode) 141683 Capitella spl (polychaete worm) ENSDARP00000075409 Danio rerio (zebra fish) ENSECAP00000018999 Equus caballus (horse) ENSGALP00000027400 Gallus gallus (chicken) ENSP00000276198 Homo sapiens (human) 82265 Lottia gigantea (owl limpet) ENSMODP00000014108 Monodelphis domestica (gray opossum) ENSMMUP00000012572 Macaca mulatta (rhesus monkey) ENSMUSP00000043936 Mus musculus (house mouse) XP_001607771.1 Nasonia vitripennis (wasp) ENSOANP00000024516 Ornithorynchus anatinus (platypus) ENSORLP00000010602 Oryzias latipes (japanese killifish) PHUM000364-PA Pediculus humanus (human body louse) PP14182 Pristionchus pacificus (nematode) ENSPPYP00000023110 Pongo pygmaeus (orangutan) ENSPTRP00000038211 Pan troglodytes (chimpanzee) ENSRNOP00000013408 Rattus norvegicus (norway rat) ENSTRUP00000044601 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021042 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/serotr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40575 modMine - Data generated by the modENCODE project. • FBgn0087012 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10792 LH20553 FBgn0242495 FBgn0215836 FBgn0209760 FBgn0191229 FBgn0165711 JGI_V11_7660 JGI_V11_8518 FBgn0070450 FBgn0159662 FBgn0147313 FBgn0125559 FBgn0104772 FBgn0093683 CPIJ011883 ACYPI008969 ACYPI007093 GB18151 GPR5HT2A GPR5HT2 PHUM220540 GLEAN_13979 GLEAN_13980
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	5-HT2 (Hoopfer et al., 2008, Heitzler, 2007.11.4, Nichols, 2007, Zhang et al., 2007, Rodriguez Moncalvo and Campos, 2009, Hou et al., 2009) 5-HT2Dro (Schaerlinger et al., 2004, Maroteaux, 1994.9.19, Maroteaux et al., 1998, Colas et al., 1996, Colas et al., 1995, Colas et al., 1995, Maroteaux, 1995.5.31, Johnson et al., 2009) 5HT2-Dro (Vanden Broeck, 2001) 5-ht2Dro (Colas et al., 1999, Maroteaux et al., 1999) 5HT2Dro (Colas et al., 1997) 5-HT2 (Colas et al., 1995, Nichols and Johnson, 2007, Shen et al., 2011, Johnson et al., 2011) 5-HT2Dro (Nichols, 2007, Johnson et al., 2011) 5-HT2Dro (Schaerlinger et al., 2007, Tierney, 2001) 5HT2Dro (Colas et al., 1999, Colas et al., 1999) 5-HT2Dro (Johnson et al., 2009) 5HT-dro1 (Hen, 1993) 5HT-R82A   CG1056 (Keleman et al., 2009.8.5, Perkins et al., 2009) d5-HT2 (Yuan et al., 2006) Dm5HT2 (Blenau and Baumann, 2001) l(3)82CDb (Schaerlinger et al., 2007, )
Name Synonym	5-HT2Dro receptor (Nichols and Johnson, 2007) lethal (3) 82CDb   Serotonin receptor 2
Secondary FlyBase IDs
	FBgn0013743 FBgn0025495
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Johnson et al., 2011, Neuroscience 192: 372--381 Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. [FBrf0215034] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...