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General Information
Symbol
Dmel\AGO2
Species
D. melanogaster
Name
Argonaute 2
Annotation Symbol
CG7439
Feature Type
FlyBase ID
FBgn0087035
Gene Model Status
Stock Availability
Gene Snapshot
Argonaute 2 (AGO2) encodes an Argonaute/Piwi family protein, which interacts with small interfering RNAs (siRNAs) to form RNA-induced silencing complexes (RISCs). RISCs are guided to target and cleave transcripts (mostly from transposons and viruses). [Date last reviewed: 2019-03-07]
Also Known As
Ago-2, dAgo2, Argonaute
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:15,554,113..15,561,042 [+]
Recombination map
3-43
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the argonaute family. Ago subfamily. (Q9VUQ5)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.
(UniProt, Q9VUQ5)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\AGO2 or the JBrowse view of Dmel\AGO2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075559
4050
1214
FBtr0075560
4117
1217
FBtr0331933
3784
787
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075312
136.9
1214
10.05
FBpp0075313
137.2
1217
10.00
FBpp0304266
90.3
787
9.60
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Fmr1, Dcr-1 and vig to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are RpL5, RpL11 and Rm62 (PubMed:11498593, PubMed:14508492, PubMed:12368261). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492). (Microbial infection) Interacts with cricket paralysis virus protein 1A; this interaction may block the RISC activity.
(UniProt, Q9VUQ5)
Domain
PAZ domain provides a major contribution for nucleic acid recognition. PAZ binds oligonucleotides of different lengths and has a strong preference for single-stranded nucleic acids (ssRNA or SSDNA) or RNA duplexes with single-stranded 3' overhangs. Can bind the characteristic two-base 3' overhangs of siRNAs, indicating that it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.
(UniProt, Q9VUQ5)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AGO2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (26 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with UniProtKB:Q9NFU0,UniProtKB:Q9V426,UniProtKB:Q9W0S7
(assigned by UniProt )
inferred from physical interaction with FLYBASE:AGO1; FB:FBgn0262739
inferred from physical interaction with FLYBASE:Fmr1; FB:FBgn0028734
inferred from physical interaction with FLYBASE:Dcr-1; FB:FBgn0039016
Terms Based on Predictions or Assertions (0 terms)
Biological Process (16 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Cellular Component (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:Q9UKV8
(assigned by UniProt )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain cell body rind

Comment: low expression in the adult brain cortex

Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AGO2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AGO2
Transgenic constructs containing regulatory region of AGO2
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
Yes
No
3 of 15
Yes
No
3 of 15
Yes
No
 
3 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
3 of 13
Yes
No
3 of 13
Yes
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
1 of 12
Yes
No
1 of 12
Yes
No
1 of 12
Yes
No
1 of 12
Yes
No
Danio rerio (Zebrafish) (6)
3 of 15
Yes
No
3 of 15
Yes
No
3 of 15
Yes
No
3 of 15
Yes
No
2 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (26)
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (10)
2 of 9
Yes
Yes
2 of 9
Yes
Yes
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902L9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila willistoni
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501EF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W015Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01AM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G020J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
4 of 10
3 of 10
3 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Fmr1, Dcr-1 and vig to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are RpL5, RpL11 and Rm62 (PubMed:11498593, PubMed:14508492, PubMed:12368261). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492). (Microbial infection) Interacts with cricket paralysis virus protein 1A; this interaction may block the RISC activity.
    (UniProt, Q9VUQ5 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-43
    Cytogenetic map
    Sequence location
    3L:15,554,113..15,561,042 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    71C3-71E5
    Left limit from inclusion within Df(3L)BK10 (FBrf0057258) Right limit from inclusion within Df(3L)BK10 (FBrf0057258)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    3-[42]
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (68)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: AGO2 CG7439
      Source for database merge of
      Source for merge of: AGO2 CG13452
      Additional comments
      "dop" is not allelic to "AGO2".
      In contrast to what is stated in FBrf0194224, the "drop out" complementation group is not allelic to "AGO2". Recently isolated mRNA null mutations of the AGO2 locus fully complement dop mutant alleles. The molecular lesions of dop mutant alleles were reported in FBrf0194224 to represent in frame deletions of glutamine rich repeats (GRR) in the amino-terminus of AGO2. Analysis of 24 different D.melanogaster haplotypes show that the amino-terminal domain of AGO2 is highly variable and that the alteration of the amino-terminal GRR pattern observed in the dop[46] allele is not unique. The GRR haplotype of dop[46] is not the cause of the developmental phenotype of embryos derived from homozygous mothers. A D.melanogaster strain with the identical GRR haplotype does not exhibit gross developmental defects.
      FlyBase curator comment: In contrast to what is stated in FBrf0194224, the "drop out" complementation group is not allelic to "AGO2" (see FBrf0211203 for more details).
      Annotations CG7439 and CG13452 merged as CG7439 in release 3 of the genome annotation.
      Other Comments
      The N-terminal glutamine rich repeat (GRR) domain of the long isoform of AGO2 appears to be subject to rapid evolution, with extensive variation in GRR copy number being seen among D. melanogaster strains isolated from natural and laboratory populations. GRR variation does not cause striking defects in embryonic development and assembly of the RNA induced silencing complex is unimpaired in embryos when GRR copy number is altered. The AGO2 locus also produces a putative short isoform that does not contain the N-terminal GRR containing domain.
      Many miRNA* species, unlike their partner mature miRNAs, are preferentially incorporated into the AGO2 complex and are 3' modified. The miRNA strand selection of AGO2 is very sensitive to the base-pairing status of the 9th and 10th position of the miRNA duplex.
      AGO2 binds endogenous short interfering RNAs (esiRNAs) derived from retrotransposons and esiRNAs arising from stem-loop structures.
      Production of mature siRNAs from endogenous long hairpin RNA genes is a hybrid mechanism that combines canonical RNA interference factors (Dcr-2, Hen1 and AGO2) and a canonical microRNA factor loqs.
      Double-stranded miRNAs and siRNAs participate in a common sorting step that partitions them into AGO1- or AGO2-containing effector complexes.
      The Dcr-2-r2d2 heterodimer acts as a gatekeeper for the assembly of AGO2 complexes, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for AGO2. A separate mechanism acts in parallel to favor miRNA/miRNA* duplexes and exclude siRNAs from assembly into AGO1 complexes.
      dsRNA made from templates generated with primers directed against this gene are used to infer a role for this gene in the miRNA pathway.
      AGO2 is in the top 3% of fastest-evolving Drosophila genes.
      AGO2 is not required for repeat-associated small interfering RNA (rasiRNA) production.
      In vitro assays show that the AGO2 protein directly receives the double-stranded siRNA from the RISC complex machinery and cleaves the siRNA passenger strand, releasing the single-stranded guide.
      AGO2 protein associated with guide siRNA is able to cleave passenger siRNA.
      AGO2 protein binds both strands of siRNA and cleaves the anti-guide strand to produce active RISC.
      dsRNA has been made from templates generated with primers directed against this gene.
      AGO1 and AGO2 are not redundant.
      The orientation of the Dcr-2/r2d2 protein heterodimer on the siRNA duplex determines which siRNA strand associates with the core RISC (RNA-induced silencing complex) protein AGO2. r2d2 protein binds the siRNA end with the greatest double-stranded character, thereby orienting the Dcr-2/r2d2 heterodimer on the siRNA duplex. Strong binding by the r2d2 protein requires a 5'-phosphate on the siRNA strand that is excluded from the RISC.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 64 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (25)
      Reported As
      Symbol Synonym
      AGO2
      (Dou et al., 2019, Harbison et al., 2019, Liu et al., 2019, Palmer et al., 2019, Rech et al., 2019, Barckmann et al., 2018, Crofton et al., 2018, Goto et al., 2018, Lee et al., 2018, Lin et al., 2018, Nazer et al., 2018, Palmer et al., 2018, Chinen and Lei, 2017, Marygold et al., 2017, Mussabekova et al., 2017, Teixeira et al., 2017, Azlan et al., 2016, Brewer-Jensen et al., 2016, Clandinin and Owens, 2016-, Guida et al., 2016, Karlikow et al., 2016, Na et al., 2016, Aradska et al., 2015, Chak et al., 2015, Merkling et al., 2015, Wen et al., 2015, Andlauer et al., 2014, Bronkhorst et al., 2014, Comoglio and Paro, 2014, Majzoub et al., 2014, Matzat and Lei, 2014, Mukherjee et al., 2014, Wen et al., 2014, Yang et al., 2014, Castel and Martienssen, 2013, Fukuyama et al., 2013, Kemp et al., 2013, Kwon et al., 2013, Meister, 2013, Okamura et al., 2013, Sentmanat et al., 2013, Smibert et al., 2013, Wei et al., 2013, Xiong et al., 2013, Graze et al., 2012, Spasic et al., 2012, Toledano et al., 2012, Berezikov et al., 2011, Chung et al., 2011, Ding and Lu, 2011, Eleftherianos et al., 2011, Friedman et al., 2011, Guan et al., 2011, Jovel and Schneemann, 2011, Khong and Jan, 2011, Kolaczkowski et al., 2011, Lindquist et al., 2011, Liu et al., 2011, Ni et al., 2011, Obbard et al., 2011, Okamura et al., 2011, Miyoshi et al., 2010, Moshkovich and Lei, 2010, Mueller et al., 2010, Swami, 2010, Czech et al., 2009, Graze et al., 2009, Habayeb et al., 2009, Hurt et al., 2009, Miyoshi et al., 2009, Okamura et al., 2009, Reich et al., 2009, Robine et al., 2009, Taft et al., 2009, Berdnik et al., 2008, Chotkowski et al., 2008, Czech et al., 2008, Deddouche et al., 2008, Haley et al., 2008, Kawamura et al., 2008, Okamura et al., 2008, Okamura et al., 2008, Teleman et al., 2008, Brower-Toland et al., 2007, Curtis et al., 2007, Eulalio et al., 2007, Grewal and Elgin, 2007, Grieder et al., 2007, Gunawardane et al., 2007, Marygold et al., 2007, Nishida et al., 2007, Behm-Ansmant et al., 2006, Dorner et al., 2006, Rehwinkel et al., 2006, Ulvila et al., 2006, Jiang et al., 2005, Miyoshi et al., 2005, Rehwinkel et al., 2005, Siomi et al., 2005, Jin et al., 2004, Okamura et al., 2004, Ishizuka et al., 2002, Hammond et al., 2001)
      Ago2
      (Martins et al., 2019, Merkling et al., 2019, Specchia et al., 2019, Deshpande and Meller, 2018, Palmer et al., 2018, Tsuboyama et al., 2018, Yamashiro and Siomi, 2018, Busto et al., 2017, Chow et al., 2017, Hyun, 2017, Kunzelmann and Förstemann, 2017, Tassetto et al., 2017, Cao et al., 2016, Lewis et al., 2016, Zhang et al., 2016, Iwasaki et al., 2015, Karaiskos et al., 2015, Liang et al., 2015, Spellberg and Marr, 2015, Abe et al., 2014, Karlikow et al., 2014, Lim et al., 2014, McElroy et al., 2014, Weidmann et al., 2014, Xu and Cherry, 2014, Gomes et al., 2013, Kingsolver et al., 2013, Li et al., 2013, Nishida et al., 2013, Thomae et al., 2013, Xie et al., 2013, Aumiller et al., 2012, Ameres et al., 2011, Cernilogar et al., 2011, Han et al., 2011, Harris et al., 2011, Liu et al., 2011, McCann et al., 2011, Ghildiyal et al., 2010, Glaser and Meola, 2010, González et al., 2010, Iwasaki et al., 2010, Miyoshi et al., 2010, Nayak et al., 2010, Berry et al., 2009, Borah et al., 2009, Iwasaki et al., 2009, Li et al., 2009, Obbard et al., 2009, Pepper et al., 2009, Sabin et al., 2009, Saleh et al., 2009, González et al., 2008, Jacquier et al., 2008, Seitz et al., 2008, Shah and Förstemann, 2008, Zhou et al., 2008, Easow et al., 2007, Förstemann et al., 2007, Kim et al., 2007, Okamura et al., 2007, Peng and Karpen, 2007, Sofola et al., 2007, Tomari et al., 2007, Zamore, 2007, Zaratiegui, 2007, Du et al., 2006, Meyer et al., 2006, Obbard et al., 2006, Sommer, 2006, Vagin et al., 2006, Valencia-Sanchez et al., 2006, Filipowicz, 2005, Hammond, 2005, Li and Ding, 2005, Matranga et al., 2005, Pham and Sontheimer, 2005, Preall and Sontheimer, 2005, Rand et al., 2005, Zamore and Haley, 2005, Lingel et al., 2004, Mason et al., 2004, Pham et al., 2004, Skipper, 2004, Tomari et al., 2004, Lingel et al., 2003, Song et al., 2003)
      CG13452
      Secondary FlyBase IDs
      • FBgn0046812
      • FBgn0036508
      • FBgn0040803
      • FBgn0004891
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • allele_used
      Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
      References (401)