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General Information
Symbol
Dmel\puc
Species
D. melanogaster
Name
puckered
Annotation Symbol
CG7850
Feature Type
FlyBase ID
FBgn0243512
Gene Model Status
Stock Availability
Enzyme Name (EC)
Protein-serine/threonine phosphatase (3.1.3.16)
Protein-tyrosine-phosphatase (3.1.3.48)
Gene Snapshot
puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. [Date last reviewed: 2019-03-14]
Also Known As
hrt, l(3)84Eh, hearty, vco
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:8,105,332..8,122,294 [+]
Recombination map
3-48
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate (3.1.3.16)
Predictions / Assertions
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)
Summaries
Gene Group (FlyBase)
DUAL SPECIFICITY PHOSPHATASES -
Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).
Summary (Interactive Fly)
dual specificity phosphatase KH-1 subfamily JNK specific phosphatase - mediates a feedback loop that regulates the Jun-N-terminal kinase pathway - functions in dorsal closure
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\puc or the JBrowse view of Dmel\puc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0081792
2919
476
FBtr0339722
2407
369
Additional Transcript Data and Comments
Reported size (kB)
2.9 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0081288
51.3
476
6.02
FBpp0308778
39.5
369
5.41
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
476 (aa); 58 (kD predicted)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\puc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (39 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
traceable author statement
inferred from electronic annotation with InterPro:IPR016130
(assigned by InterPro )
inferred from sequence or structural similarity
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN001605855
(assigned by GO_Central )
Biological Process (31 terms)
Terms Based on Experimental Evidence (27 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q7K5M0
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002468407
(assigned by GO_Central )
inferred from sequence or structural similarity
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001605855
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
epidermis | dorsal

Comment: reference states 4-8 hr AEL

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
puc transcripts are detected throughout embryogenesis by northern blot. By in situ hybridization, puc transcripts are detected weakly in the dorsal-most cells at the leading edge of the epidermis. After stage 11, expression decays.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{A92}pucE69
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lArB}pucA251.1F3
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PTT-un}pucG00462
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\puc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4Act5C.PI
dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4Act5C.PI, pucE69
dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4Act5C.PI, pucUAS.cMa
dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4Act5C.PI
dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4Act5C.PI, pucE69
dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4Act5C.PI, pucUAS.cMa
nucleus & follicle cell | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
 
4 of 15
Yes
No
4 of 15
No
Yes
3 of 15
Yes
No
 
3 of 15
Yes
No
3 of 15
No
No
 
3 of 15
No
No
 
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
 
2 of 15
Yes
No
2 of 15
No
No
 
2 of 15
Yes
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
4 of 15
No
Yes
4 of 15
No
No
3 of 15
Yes
No
3 of 15
No
Yes
3 of 15
Yes
No
 
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
Yes
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (31)
6 of 13
Yes
Yes
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
 
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (19)
4 of 12
Yes
No
3 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (37)
6 of 15
Yes
Yes
5 of 15
No
Yes
4 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
4 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
3 of 9
Yes
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
7 of 15
Yes
Yes
6 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
5 of 12
Yes
Yes
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BGC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915074Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07DR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0B16 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0249 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
4 of 10
4 of 10
3 of 10
3 of 10
2 of 10
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
     
    Expression of pucScer\UAS.cMa ameliorates tumor-like growth and invasion when Ras85DV12.Scer\UAS is expressed in l(2)gl4 mutant cells.
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-48
    Cytogenetic map
    Sequence location
    3R:8,105,332..8,122,294 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    84E12-84E11
    Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930; Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    84E10-84E11
    (determined by in situ hybridisation)
    84F-84F
    (determined by in situ hybridisation)
    84E-84E
    (determined by in situ hybridisation)
    84F1-84F2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (35)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (72)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: puc CG7850
    Source for database merge of
    Source for merge of: puc hrt
    Source for merge of: puc l(3)j4E1
    Additional comments
    Other Comments
    dsRNA directed against puc inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.
    dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.
    Proper levels of puc activity in the follicle cells are critical for the production of a normal egg.
    Either reduced or increased puc activity results in incomplete nurse cell dumping and aberrant dorsal appendages.
    Mutations in puc, a known negative regulator of JNK signaling, suppress both the dorsal closure and ventral segment polarity defects associated with a decrease in wg signaling.
    puc normally antagonizes wg signalling in the ventral epidermis.
    Loss of function and gain of function mutants in puc cause planar polarity phenotypes in the eye.
    hep controls puc expression but not dpp expression in imaginal discs.
    Candidate gene for quantitative trait (QTL) locus determining bristle number.
    puc has a negative regulatory role in thorax closure during metamorphosis.
    puc encodes a phosphatase that regulates signaling through the bsk pathway and participates in a negative feedback loop leading to a transient activity of the bsk signal during dorsal closure.
    puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.
    puc expression is regulated by bsk function.
    puc is negatively autoregulated in the follicle cells and that depression of puc in the squamous follicle cells at stage 10 is necessary for nurse cell transport.
    Ectopic expression of puc can cause defects in dorsal closure, dorsal puckering and denticle belt patterning. These phenotypes overlap those caused by loss of function alleles of puc.
    The General Council of the Velcro Group Corporation prohibited the use of the name 'velcro' for this gene, as that would constitute an infringement of trademark.
    Mutation in puc affects neuronal connections, affecting fasciculation.
    puc is required for PNS development in the embryo.
    Origin and Etymology
    Discoverer
    L. and Y. Jan.
    Etymology
    Identification
    External Crossreferences and Linkouts ( 66 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (20)
    Reported As
    Symbol Synonym
    l(3)A251.1
    l(3)j4E1
    puc
    (Binh et al., 2019, Galenza and Foley, 2019, Ma et al., 2019, Pinal et al., 2019, Sun et al., 2019, Sun et al., 2019, Wang et al., 2019, Wang et al., 2019, Zhang et al., 2019, Zhu et al., 2019, Ahmed-de-Prado and Baonza, 2018, Akagi et al., 2018, Bardai et al., 2018, Bushnell et al., 2018, Doupé et al., 2018, Dutta et al., 2018, Feng et al., 2018, Hao et al., 2018, Kumar and Tiwari, 2018, Luong et al., 2018, Mlih et al., 2018, Mondal et al., 2018, Palu and Chow, 2018, Paul et al., 2018, Pinal et al., 2018, Resende et al., 2018, Sarkar et al., 2018, Sharma et al., 2018, Wang et al., 2018, Wang et al., 2018, Yanku et al., 2018, Yu et al., 2018, Jordán-Álvarez et al., 2017, Lee et al., 2017, Liu and Jin, 2017, Ma et al., 2017, Ma et al., 2017, Ma et al., 2017, Martín et al., 2017, Rao and Rolls, 2017, Takemura and Nakato, 2017, Taylor et al., 2017, Wang et al., 2017, Xie et al., 2017, Xu et al., 2017, Zhou et al., 2017, Aggarwal et al., 2016, Agrawal et al., 2016, Bonfini et al., 2016, Calleja et al., 2016, Clandinin and Owens, 2016-, Deng et al., 2016, Diaz-Garcia et al., 2016, Li et al., 2016, Ma et al., 2016, Maistrenko et al., 2016, Tare et al., 2016, Voelzmann et al., 2016, Willsey et al., 2016, Yasin et al., 2016, Zhang et al., 2016, Álvarez-Fernández et al., 2015, Andersen et al., 2015, Chen et al., 2015, Doggett et al., 2015, Flores-Benitez and Knust, 2015, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Katsuyama et al., 2015, Kavi et al., 2015, Kim et al., 2015, Külshammer et al., 2015, Legent et al., 2015, Lim et al., 2015, Liu et al., 2015, Merino et al., 2015, Moreno et al., 2015, Ríos-Barrera et al., 2015, Srivastava, 2015, West et al., 2015, Wu et al., 2015, Yamamoto-Hino et al., 2015, Zaessinger et al., 2015, Zang et al., 2015, Zhai et al., 2015, Zhang et al., 2015, Zimmermann et al., 2015, Ashwal-Fluss et al., 2014, Ballard et al., 2014, Ballesteros-Arias et al., 2014, Brace et al., 2014, Fan et al., 2014, Handke et al., 2014, Herrera and Morata, 2014, Huang et al., 2014, Li et al., 2014, Okumura et al., 2014, Pereira et al., 2014, Ruiz et al., 2014, Sing et al., 2014, Sopko et al., 2014, Yanai et al., 2014, Bai et al., 2013, Bonke et al., 2013, Carter, 2013, Das et al., 2013, Herrera et al., 2013, Humphreys et al., 2013, Hwang et al., 2013, Klinedinst et al., 2013, Külshammer and Uhlirova, 2013, Langen et al., 2013, Losick et al., 2013, Macdonald et al., 2013, Ma et al., 2013, Ma et al., 2013, Owusu-Ansah et al., 2013, Pechkovsky et al., 2013, Perea et al., 2013, Pérez-Garijo et al., 2013, Petzoldt et al., 2013, Schertel et al., 2013, Sen et al., 2013, Tamori and Deng, 2013, Valakh et al., 2013, Vaque et al., 2013, Whitaker et al., 2013, Woodfield et al., 2013, Yang et al., 2013, Yin et al., 2013, Bangi et al., 2012, Belozerov et al., 2012, Chakrabarti et al., 2012, Chatterjee and Bohmann, 2012, Colombani et al., 2012, Eleftherianos and Castillo, 2012, Foronda et al., 2012, Gonda et al., 2012, Gowda et al., 2012, Jemc et al., 2012, Kapfhamer et al., 2012, Kelsey et al., 2012, Lada et al., 2012, Lim et al., 2012, Lu et al., 2012, Ma et al., 2012, Marchal et al., 2012, Meinander et al., 2012, Nam et al., 2012, Pezzulo et al., 2012, Poernbacher et al., 2012, Rynes et al., 2012, Abruzzi et al., 2011, Belacortu et al., 2011, Boyd et al., 2011, Glittenberg et al., 2011, Greenberg and Hatini, 2011, Huang et al., 2011, Jiang et al., 2011, Jiang et al., 2011, Marinho et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Opota et al., 2011, Repiso et al., 2011, Resnik-Docampo and de Celis, 2011, Rumpf et al., 2011, Seisenbacher et al., 2011, Tare et al., 2011, Tripura et al., 2011, Beam and Moberg, 2010, Bergantiños et al., 2010, Bergantiños et al., 2010, Bhuin and Roy, 2010, Bosch et al., 2010, Campos et al., 2010, Chen et al., 2010, Gettings et al., 2010, Lam et al., 2010, Lennox and Stronach, 2010, Li et al., 2010, Neisch et al., 2010, Okumura et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Rousset et al., 2010, Shaw et al., 2010, Singh et al., 2010, Sorrosal et al., 2010, Sun et al., 2010, Tamori et al., 2010, Umehara et al., 2010, Vidal et al., 2010, Wang and Ward, 2010, Wang et al., 2010, Warner et al., 2010, Wu et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Zhang et al., 2010, Apidianakis et al., 2009, Baril et al., 2009, Buchon et al., 2009, Cruz et al., 2009, Dichtel-Danjoy et al., 2009, Glavic et al., 2009, González et al., 2009, Hull-Thompson et al., 2009, Jiang et al., 2009, Mallik and Lakhotia, 2009, Massaro et al., 2009, McNamee and Brodsky, 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shen et al., 2009, Thevenon et al., 2009, Tiwari and Roy, 2009, Tuxworth et al., 2009, Umemori et al., 2009, Wu et al., 2009, Ziv et al., 2009, Bakal et al., 2008, Bates et al., 2008, Biteau et al., 2008, Bosch et al., 2008, Carrera et al., 2008, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Doheny et al., 2008, FlyBase Curators, 2008-, Grima et al., 2008, Griswold et al., 2008, Kleino et al., 2008, Libert et al., 2008, Llense and Martín-Blanco, 2008, Maillet et al., 2008, McNamee and Brodsky, 2008, Owusu-Ansah et al., 2008, Pastor-Pareja et al., 2008, Weber et al., 2008, Xi et al., 2008, Yoshioka et al., 2008, Avet-Rochex et al., 2007, Baeg et al., 2007, Bidla et al., 2007, Chen et al., 2007, Kankel et al., 2007, Kirchner et al., 2007, Krieser et al., 2007, Langton et al., 2007, Libert et al., 2007, Lin et al., 2007, Löw et al., 2007, Luo et al., 2007, Manjon et al., 2007, Neuman-Silberberg, 2007, Pfleger et al., 2007, Quinones-Coello, 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Umemori et al., 2007, Xue et al., 2007, Zeitlinger et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Balakireva et al., 2006, Cerrato et al., 2006, Delaney et al., 2006, Dionne et al., 2006, Friedman and Perrimon, 2006, Herz et al., 2006, Homsy et al., 2006, Hyun et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jordan et al., 2006, Lee et al., 2006, Murray et al., 2006, Polaski et al., 2006, Sato et al., 2006, Schimmelpfeng et al., 2006, Singh et al., 2006, Srahna et al., 2006, Tsuda et al., 2006, Uhlirova and Bohmann, 2006, Coffman et al., 2005, Gesellchen et al., 2005, Jordan et al., 2005, Lee et al., 2005, Mattila et al., 2005, McEwen and Peifer, 2005, Nelson et al., 2005, Tsuda et al., 2005, Pastor-Pareja et al., 2004, Ryoo et al., 2004, Wheeler et al., 2004, Cha et al., 2003, Jiang and Crews, 2003, Boutros et al., 2002, Sem et al., 2002)
    Name Synonyms
    Jun N-terminal kinase dual-specificity phosphatase
    lethal (3) j4E1
    puckered
    (Jeong et al., 2018, Paul et al., 2018, Romey-Glüsing et al., 2018, Wang et al., 2018, Brace and DiAntonio, 2017, Lu et al., 2017, Muzzopappa et al., 2017, Takemura and Nakato, 2017, Whon et al., 2017, Yadav et al., 2017, Maistrenko et al., 2016, Katsuyama et al., 2015, Lim et al., 2015, Simon and Guerrero, 2015, Su, 2015, West et al., 2015, Yamamoto-Hino et al., 2015, Fernando et al., 2014, Handke et al., 2014, Pereira et al., 2014, Das et al., 2013, Herrera et al., 2013, Humphreys et al., 2013, Külshammer and Uhlirova, 2013, Losick et al., 2013, Macdonald et al., 2013, Ma et al., 2013, Owusu-Ansah et al., 2013, Pérez-Garijo et al., 2013, Tamori and Deng, 2013, Bangi et al., 2012, Colombani et al., 2012, Eleftherianos and Castillo, 2012, Foronda et al., 2012, Förster and Luschnig, 2012, Jemc et al., 2012, Lu et al., 2012, Meinander et al., 2012, Wang et al., 2012, Boyd et al., 2011, Jiang et al., 2011, Miles et al., 2011, Repiso et al., 2011, Beam and Moberg, 2010, Bergantiños et al., 2010, Bergantiños et al., 2010, Campos et al., 2010, Gettings et al., 2010, Lennox and Stronach, 2010, Li et al., 2010, Okumura et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Radyuk et al., 2010, Rousset et al., 2010, Tamori et al., 2010, Umehara et al., 2010, Vidal et al., 2010, Wang and Ward, 2010, Warner et al., 2010, Xiong et al., 2010, Buchon et al., 2009, Dichtel-Danjoy et al., 2009, Ha et al., 2009, Jiang et al., 2009, Mallik and Lakhotia, 2009, Massaro et al., 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shalaby et al., 2009, Shen et al., 2009, Wu et al., 2009, Bakal et al., 2008, Bates et al., 2008, Bosch et al., 2008, Doheny et al., 2008, Grima et al., 2008, Kleino et al., 2008, Llense and Martín-Blanco, 2008, Maillet et al., 2008, Melani et al., 2008, Owusu-Ansah et al., 2008, Weber et al., 2008, Yoshioka et al., 2008, Avet-Rochex et al., 2007, Kankel et al., 2007, Lee et al., 2007, Manjon et al., 2007, Mathieu et al., 2007, Neuman-Silberberg, 2007, Tadros et al., 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Xue et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Cerrato et al., 2006, Eissenberg, 2006, Homsy et al., 2006, Lee et al., 2006, Leulier et al., 2006, Sato et al., 2006, Tsuda et al., 2006, Jordan et al., 2005, Lee et al., 2005, Mattila et al., 2005, Nelson et al., 2005, Tsuda et al., 2005, Wang et al., 2004, Cha et al., 2003, Jiang and Crews, 2003, Kauppila et al., 2003, Martin-Blanco, 1998.1.12)
    velcro
    Secondary FlyBase IDs
    • FBgn0011600
    • FBgn0004210
    • FBgn0011369
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (618)