FlyBase Gene Report: Dmel\puc

General Information

Symbol

Dmel\puc

Species

D. melanogaster

Name

puckered

Annotation Symbol

CG7850

Feature Type

protein_coding_gene

FlyBase ID

FBgn0243512

Gene Model Status

Current

Stock Availability

25 publicly available

Enzyme Name (EC)

Protein-serine/threonine phosphatase (3.1.3.16)

Protein-tyrosine-phosphatase (3.1.3.48)

Gene Snapshot

puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

hrt, l(3)84Eh, hearty, vco

Key Links

Genomic Location

Cytogenetic map

84E12-84E11

Sequence location

3R:8,105,332..8,122,294 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8105332..8122294

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

DUAL SPECIFICITY PHOSPHATASES

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

JUN kinase phosphatase activity; phosphoprotein phosphatase activity

Predictions / Assertions

protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Catalytic Activity (EC)

Experimental Evidence

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate (3.1.3.16)

Predictions / Assertions

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Summaries

Gene Group (FlyBase)

DUAL SPECIFICITY PHOSPHATASES -: Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)

Summary (Interactive Fly)

dual specificity phosphatase KH-1 subfamily JNK specific phosphatase - mediates a feedback loop that regulates the Jun-N-terminal kinase pathway - functions in dorsal closure

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\puc or the JBrowse view of Dmel\puc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

puc-RA

FBtr0081792

NM_079549

2919

476

puc-RB

FBtr0339722

NM_001300294

2407

369

Additional Transcript Data and Comments

Reported size (kB)

2.9 (northern blot)

(Martin-Blanco et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

puc-PA

FBpp0081288

51.3

476

6.02

NP_524273

AAF54191

puc-PB

FBpp0308778

39.5

369

5.41

NP_001287223

AHN57222

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

476 (aa); 58 (kD predicted)

(Martin-Blanco et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\puc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

puc_1
puc_2

Linkouts

Gene Ontology (36 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

JUN kinase phosphatase activity

inferred from mutant phenotype

(Martin-Blanco et al., 1998)

phosphoprotein phosphatase activity

inferred from direct assay

(Martin-Blanco et al., 1998)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

protein tyrosine phosphatase activity

inferred from electronic annotation with InterPro:IPR016130

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

protein tyrosine/serine/threonine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN001605855

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (29 terms)

Terms Based on Experimental Evidence (28 terms)

CV Term

Evidence

References

actin cytoskeleton organization

inferred from mutant phenotype

(Martin-Blanco et al., 1998)

cellular response to oxidative stress

inferred from direct assay

(Wu et al., 2009)

chitin-based embryonic cuticle biosynthetic process

inferred from mutant phenotype

(McEwen and Peifer, 2005)

chorion micropyle formation

inferred from mutant phenotype

(Suzanne et al., 2001)

compound eye development

inferred from mutant phenotype

(McEwen and Peifer, 2005)

determination of adult lifespan

inferred from mutant phenotype

(Libert et al., 2008, Wang et al., 2003)

determination of digestive tract left/right asymmetry

inferred from mutant phenotype

(Taniguchi et al., 2007)

dorsal appendage formation

inferred from mutant phenotype

(Suzanne et al., 2001)

dorsal closure

inferred from mutant phenotype

(Ring and Martinez Arias, 1993)

embryonic anterior midgut (ectodermal) morphogenesis

inferred from mutant phenotype

(Taniguchi et al., 2007)

epidermis development

inferred from mutant phenotype

(Ring and Martinez Arias, 1993)

imaginal disc eversion

inferred from mutant phenotype

(Pastor-Pareja et al., 2004)

imaginal disc fusion

inferred from mutant phenotype

(Pastor-Pareja et al., 2004)

imaginal disc fusion, thorax closure

inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018

(Baril et al., 2009)

imaginal disc-derived male genitalia morphogenesis

inferred from mutant phenotype

(assigned by UniProt )

(Rousset et al., 2010)

inferred from genetic interaction with UniProtKB:Q7K5M0

(assigned by UniProt )

(Rousset et al., 2010)

JNK cascade

inferred from mutant phenotype

(Martin-Blanco et al., 1998)

negative regulation of apoptotic process

inferred from mutant phenotype

(McEwen and Peifer, 2005)

negative regulation of peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Delaney et al., 2006, Boutros et al., 2002)

negative regulation of stress-activated protein kinase signaling cascade

inferred from mutant phenotype

(Boutros et al., 2002)

ovarian follicle cell development

inferred from mutant phenotype

(Jordan et al., 2006)

positive regulation of border follicle cell migration

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Mathieu et al., 2007)

inferred from mutant phenotype

(assigned by UniProt )

(Melani et al., 2008)

positive regulation of gene expression

inferred from mutant phenotype

(assigned by UniProt )

(Sorrosal et al., 2010)

positive regulation of immune response

inferred from mutant phenotype

(Libert et al., 2008)

protein dephosphorylation

inferred from direct assay

(Martin-Blanco et al., 1998)

protein secretion

inferred from mutant phenotype

(Bard et al., 2006)

regulation of G2/M transition of mitotic cell cycle

inferred from mutant phenotype

(Chen et al., 2007)

response to oxidative stress

inferred from mutant phenotype

(Wu et al., 2009, Wang et al., 2003)

wound healing

inferred from expression pattern

(Ramet et al., 2002)

inferred from mutant phenotype

(Bosch et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

inactivation of MAPK activity

inferred from biological aspect of ancestor with PANTHER:PTN002468407

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

endoplasmic reticulum

inferred from direct assay

(Bard et al., 2006)

Golgi apparatus

inferred from direct assay

(Bard et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN001605855

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

epidermis | dorsal

Comment: reference states 4-8 hr AEL

(Martin-Blanco et al., 1998)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Martin-Blanco et al., 1998)

Additional Descriptive Data

puc transcripts are detected throughout embryogenesis by northern blot. By in situ hybridization, puc transcripts are detected weakly in the dorsal-most cells at the leading edge of the epidermis. After stage 11, expression decays.

(Martin-Blanco et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

endoplasmic reticulum

inferred from direct assay

(Bard et al., 2006)

Golgi apparatus

inferred from direct assay

(Bard et al., 2006)

Expression Deduced from Reporters

Reporter: P{A92}puc^E69

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 15

amnioserosa | ventral to

(Ring and Martinez Arias, 1993)

embryonic stage 11 -- 17

epidermis | dorsal

(Ring and Martinez Arias, 1993)

third instar larval stage

wing disc | restricted

(del Alamo Rodriguez et al., 2004)

embryonic stage 13 -- 16

embryonic leading edge cell

(Stronach and Perrimon, 2001)

embryonic stage 15

embryonic leading edge cell

(Goberdhan and Wilson, 1998)

embryonic stage 14

embryonic leading edge cell

(Tateno et al., 2000)

embryonic stage

leading edge mixer cell | subset

(Gettings et al., 2010)

embryonic stage 14 -- 15

embryonic leading edge cell

(Magie et al., 1999)

Reporter: P{GAL4E69}puc^GAL4E69

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval head sense organ | subset

(Adachi-Yamada, 2002)

embryonic/larval peripheral nervous system | restricted

(Adachi-Yamada, 2002)

adult stage | male

seminal vesicle

(Adachi-Yamada, 2002)

male accessory gland

(Adachi-Yamada, 2002)

Reporter: P{GawB}puc^E69-unk

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

female genital disc | restricted

(Benitez et al., 2010)

male genital disc | restricted

(Benitez et al., 2010)

wandering third instar larval stage

anterior-posterior compartment boundary of the female genital disc

(Benitez et al., 2010)

anterior-posterior compartment boundary of the male genital disc

(Benitez et al., 2010)

prepupal stage

female genital disc | restricted

(Benitez et al., 2010)

male genital disc | restricted

(Benitez et al., 2010)

Reporter: P{lArB}puc^A251.1F3

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

ventral thoracic disc | distal

(Azpiazu and Morata, 2002)

embryonic stage

epidermis | dorsal

(Bellen, 1998.8.10)

amnioserosa | vicinity of

(Bellen, 1998.8.10)

adult stage & oogenesis stage S10

follicle cell

(Bellen, 1998.8.10)

Reporter: P{PTT-un}puc^G00462

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 14

longitudinal visceral muscle primordium

(Taniguchi et al., 2007)

embryonic dorsal epidermis

(Taniguchi et al., 2007)

embryonic stage 10 -- 11

amnioserosa

(Taniguchi et al., 2007)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\puc in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\puc

View exonic expression by tissue for Dmel\puc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0243512

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0243512

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7850

Flygut - An atlas of the Drosophila adult midgut

FBgn0243512

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 54 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of puc

Transgenic constructs containing regulatory region of puc

Deletions and Duplications ( 21 )

Not disrupted in

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

lethal

lethal | pupal stage, with Scer\GAL4^pnr-MD237

puc^GD1515

lethal | recessive

lethal | somatic clone

puc^E69

lethal - all die before end of embryonic stage | dominant

puc^A251.1F3

lethal - all die before end of embryonic stage | recessive

lethal - all die before end of pupal stage | recessive

puc^E69-F

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

puc^GD1515

partially lethal - majority live | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

puc^GD1515

viable, with Scer\GAL4^en-e16E

puc^{Dead.UAS.Tag:MYC}

viable, with Scer\GAL4^Mef2.PR

puc^GD1515

viable, with Scer\GAL4^tin.CΔ4

puc^GD1515

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

puc^GL00504

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

female semi-sterile | germline clone

puc^A251.1F3

female sterile | germline clone

puc¹

fertile

sterile | recessive

Other Phenotypes

Allele

cell migration defective | third instar larval stage, with Scer\GAL4^ptc-559.1

puc^GD1515

chemical resistant | dominant

decreased fecundity | female | germline clone

puc^A251.1F3

developmental rate defective | embryonic stage

puc^A251.1F3

increased cell death

puc^A251.1F3

increased cell death | third instar larval stage, with Scer\GAL4^ptc-559.1

puc^GD1515

locomotor behavior defective | day 40 of adulthood | dominant

puc^E69

long lived | dominant

neuroanatomy defective, with Scer\GAL4^elav-C155

puc^UAS.cMa

neuroanatomy defective, with Scer\GAL4^GMR.PF

puc^UAS.cMa

neurophysiology defective, with Scer\GAL4^elav-C155

puc^UAS.cMa

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

puc^unspecified

oxidative stress response defective | adult stage | dominant

puc^E69

oxidative stress response defective | dominant

puc^E69

planar polarity defective, with Scer\GAL4^hs.2sev

puc^UAS.cMa

radiation resistant, with Scer\GAL4^en-e16E

puc^UASp.Tag:MYC

size defective | somatic clone, with Scer\GAL4^Act5C.PU

puc^{dsRNA.UAS.cUa}

some die during embryonic stage | dominant

puc^A251.1F3

some die during embryonic stage | recessive

some die during pupal stage | recessive

puc^E69-F

stress response defective | dominant

puc^E69

suppressor of variegation | dominant, with In(1)w^m4

puc^unspecified

visible, with Scer\GAL4^455.2

puc^UAS.cMa

visible, with Scer\GAL4^Abd-B-LDN

puc^UAS.cMa

visible, with Scer\GAL4^ap-md544

puc^UAS.cMa

visible, with Scer\GAL4^en-e16E

puc^UAS.cMa

visible, with Scer\GAL4^hs.2sev

puc^UAS.cMa

visible, with Scer\GAL4^opa

puc^EP3194

visible, with Scer\GAL4^pnr-MD237

puc^UAS.cMa

visible, with Scer\GAL4^ptc-559.1

wild-type

puc^E69-A

wild-type, with Scer\GAL4^nub-AC-62

puc^UAS.cMa

wound healing defective, with Scer\GAL4^en-e16E

puc^UAS.cMa

Phenotype manifest in

Allele

adult external abdomen | dorsal, with Scer\GAL4^dpp.blk1

puc^UAS.cMa

adult external abdomen | dorsal, with Scer\GAL4^en-e16E

puc^UAS.cMa

adult thorax, with Scer\GAL4^ap-md544

puc^UAS.cMa

adult thorax, with Scer\GAL4^LE

puc^UAS.cMa

adult thorax, with Scer\GAL4^opa

puc^EP3194

adult thorax, with Scer\GAL4^pnr-MD237

puc^UAS.cMa

anterior crossvein, with Scer\GAL4^ptc-559.1

puc^{dsRNA.UAS.cUa}

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

puc^GD1515

bouton, with Scer\GAL4^elav-C155

puc^UAS.cMa

cardioblast

puc^E69

chorion | maternal effect | somatic clone

puc^A251.1F3

collar | maternal effect | somatic clone

puc^A251.1F3

denticle belt

puc^A251.1F3

denticle belt | maternal effect

puc^A251.1F3

dorsal appendage, with Scer\GAL4^55B

puc^UAS.cMa

dorsal appendage, with Scer\GAL4^CY2

puc^UAS.cMa

dorsal appendage, with Scer\GAL4^hs.PB

puc^UAS.cMa

dorsal appendage, with Scer\GAL4^T155

puc^UAS.cMa

dorsal appendage | maternal effect | somatic clone

puc^A251.1F3

dorsal fine hair

puc^E69

dorsal hair

puc^A251.1F3

dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4^Act5C.PI

puc^UAS.cMa

dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4^Act5C.PI, puc^E69

puc^UAS.cMa

dorsal mesothoracic disc & peripodial epithelium & prepupa, with Scer\GAL4^Act5C.PI, puc^UAS.cMa

puc^E69

dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4^Act5C.PI

puc^UAS.cMa

dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4^Act5C.PI, puc^E69

puc^UAS.cMa

dorsal mesothoracic disc & peripodial stalk & prepupa, with Scer\GAL4^Act5C.PI, puc^UAS.cMa

puc^E69

egg, with Scer\GAL4^hs.PB

puc^UAS.cMa

egg | maternal effect | somatic clone

puc^A251.1F3

egg | somatic clone, with Scer\GAL4^Act5C.PP

puc^UAS.cMa

egg operculum | maternal effect | somatic clone

puc^A251.1F3

ejaculatory bulb, with Scer\GAL4^dpp.blk1

puc^UAS.cMa

ejaculatory bulb, with Scer\GAL4^en-e16E

puc^UAS.cMa

ejaculatory duct, with Scer\GAL4^dpp.blk1

puc^UAS.cMa

ejaculatory duct, with Scer\GAL4^en-e16E

puc^UAS.cMa

embryo | dorsal, with Scer\GAL4^69B

puc^UAS.cMa

embryo | dorsal, with Scer\GAL4^e22c

puc^UAS.cMa

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

puc^HMS04497

embryonic/first instar larval cuticle

puc^E69

embryonic/first instar larval cuticle, with Scer\GAL4^69B

puc^UAS.cMa

embryonic/first instar larval cuticle | dorsal

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^hs.PB

puc^UAS.cMa

embryonic/first instar larval cuticle | maternal effect

puc^A251.1F3

embryonic/larval anterior midgut

embryonic/larval anterior midgut (with Df(3R)dsx10D)

puc^GS16811

embryonic/larval anterior midgut | heat sensitive, with Scer\GAL4^hs.PU

puc^UAS.cMa

embryonic/larval dorsal vessel | posterior

embryonic/larval proventriculus

puc^GS16811

embryonic dorsal epidermis

embryonic dorsal vessel

puc^E69

embryonic epidermis

puc^E69

embryonic epidermis | dorsal

embryonic epidermis | dorsal, with Scer\GAL4^arm.PS

puc^UAS.cMa

embryonic epidermis | dorsal, with Scer\GAL4^VP16.arm

puc^UAS.cMa

embryonic leading edge cell

puc^E69

embryonic leading edge cell, with Scer\GAL4^ptc-559.1

puc^UAS.cMa

embryonic segment | dorsal

puc²

embryonic segment | maternal effect

puc^A251.1F3

epandrium, with Scer\GAL4^en-e16E

puc^UAS.cMa

epandrium, with Scer\GAL4^ptc-559.1

puc^UAS.cMa

eye

eye, with Scer\GAL4^GMR.PF

puc^UAS.cMa

eye, with Scer\GAL4^hs.2sev

puc^UAS.cMa

eye disc | somatic clone

puc^E69

eye photoreceptor cell, with Scer\GAL4^GMR.PF

puc^UAS.cMa

follicle cell | somatic clone

puc^A251.1F3

germline cell | embryonic stage 15

puc^E69

imaginal disc

lamina, with Scer\GAL4^GMR.PF

puc^UAS.cMa

macrochaeta | supernumerary, with Scer\GAL4^ptc-559.1

puc^UASp.Tag:MYC

male genitalia, with Scer\GAL4^en-e16E

puc^UASp.Tag:MYC

male terminalia, with Scer\GAL4^Abd-B-LDN

puc^UAS.cMa

male terminalia, with Scer\GAL4^dpp.blk1

puc^UAS.cMa

male terminalia, with Scer\GAL4^en-e16E

puc^UAS.cMa

male terminalia, with Scer\GAL4^ptc-559.1

puc^UAS.cMa

mesothoracic cleft | ectopic, with Scer\GAL4^ap-md544

puc^UAS.cMa

mesothoracic tergum, with Scer\GAL4^pnr-MD237

puc^UAS.cMa

micropyle, with Scer\GAL4^55B

puc^UAS.cMa

micropyle, with Scer\GAL4^CY2

puc^UAS.cMa

micropyle, with Scer\GAL4^slbo.2.6

puc^UAS.cMa

micropyle, with Scer\GAL4^T155

puc^UAS.cMa

neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

puc^UAS.cMa

neuron, with Scer\GAL4^GMR.PF

puc^UAS.cMa

nucleus & follicle cell | somatic clone

puc^A251.1F3

nurse cell | maternal effect | somatic clone

puc^A251.1F3

nurse cell | somatic clone, with Scer\GAL4^Act5C.PP

puc^UAS.cMa

ommatidium, with Scer\GAL4^hs.2sev

puc^UAS.cMa

peripheral nervous system

puc^H246

presumptive embryonic/larval peripheral nervous system

scutellar bristle | ectopic, with Scer\GAL4^455.2

puc^UAS.cMa

scutellum, with Scer\GAL4^455.2

puc^UAS.cMa

ventral midline | dorsal

puc^E69

wing disc, with Scer\GAL4^Bx-MS1096-KE

puc^UAS.cMa

wing disc, with Scer\GAL4^en-e16E

puc^UAS.cMa

wing disc | prepupal stage, with Scer\GAL4^Act5C.PI

puc^UAS.cMa

wing disc | prepupal stage, with Scer\GAL4^Act5C.PI, puc^E69

puc^UAS.cMa

wing disc | prepupal stage, with Scer\GAL4^Act5C.PI, puc^UAS.cMa

puc^E69

wing disc | somatic clone, with Scer\GAL4^Act5C.PU

puc^{dsRNA.UAS.cUa}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (32)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DUSP10

8 of 15

Yes

Hsap\DUSP8

4 of 15

Yes

Hsap\DUSP16

4 of 15

Yes

Hsap\DUSP1

3 of 15

Yes

Hsap\DUSP4

3 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (30)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dusp10

7 of 15

Yes

Mmus\Dusp16

4 of 15

Yes

Mmus\Dusp28

4 of 15

Mmus\Dusp1

3 of 15

Yes

Mmus\Dusp4

3 of 15

Yes

Mmus\Dusp8

3 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

Yes

Mmus\Dusp3

2 of 15

Mmus\Dusp5

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Megf9

1 of 15

Mmus\Styxl1

1 of 15

Yes

Mmus\Styx

1 of 15

Rattus norvegicus (Norway rat) (32)

Rnor\Dusp10

5 of 13

Yes

Rnor\Dusp16

3 of 13

Yes

Rnor\Dupd1

2 of 13

Rnor\Dusp1

2 of 13

Yes

Rnor\Dusp2

2 of 13

Yes

Rnor\Dusp3

2 of 13

Rnor\Dusp4

2 of 13

Yes

Rnor\Dusp5

2 of 13

Yes

Rnor\Dusp8

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\LOC100909469

1 of 13

Yes

Rnor\LOC108348179

1 of 13

Rnor\LOC108348213

1 of 13

Yes

Rnor\Megf9

1 of 13

Rnor\Styxl1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (29)

Xtro\dusp28

4 of 12

Yes

Xtro\dusp10

3 of 12

Yes

Xtro\dupd1

2 of 12

Xtro\dusp1

2 of 12

Yes

Xtro\dusp4

2 of 12

Yes

Xtro\dusp5

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\dusp3

1 of 12

Yes

Xtro\dusp6

1 of 12

Xtro\dusp8

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\dusp27

1 of 12

Yes

Xtro\epm2a

1 of 12

Yes

Xtro\LOC100492691

1 of 12

Yes

Xtro\LOC101734793

1 of 12

Yes

Xtro\LOC105947969

1 of 12

Xtro\ssh3

1 of 12

Yes

Xtro\styxl1

1 of 12

Yes

Danio rerio (Zebrafish) (45)

Drer\si:dkey-175m17.7

5 of 15

Yes

Drer\dusp10

4 of 15

Yes

Drer\dusp28

4 of 15

Drer\dusp4

3 of 15

Yes

Drer\dusp14

3 of 15

Drer\dusp16

3 of 15

Yes

Drer\LOC100150565

3 of 15

Drer\si:ch211-121a2.2

3 of 15

Drer\si:ch211-195b15.8

3 of 15

Yes

Drer\si:ch211-203d1.3

3 of 15

Drer\ssh2a

3 of 15

Drer\dusp1

2 of 15

Yes

Drer\dusp2

2 of 15

Yes

Drer\dusp3a

2 of 15

Drer\dusp3b

2 of 15

Drer\dusp5

2 of 15

Yes

Drer\dusp8a

2 of 15

Yes

Drer\dusp8b

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\LOC100538052

2 of 15

Yes

Drer\si:ch211-223p8.8

2 of 15

Drer\si:ch1073-184j22.2

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\LOC100333749

1 of 15

Yes

Drer\LOC108179554

1 of 15

Yes

Drer\LOC108179555

1 of 15

Yes

Drer\LOC110440191

1 of 15

Drer\si:dkey-220k22.1

1 of 15

Drer\styxl1

1 of 15

Yes

Drer\zgc:153981

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\F13D11.3

4 of 15

Yes

Cele\vhp-1

4 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\DSPTP1

1 of 9

Yes

Atha\IBR5

1 of 9

Yes

Atha\MKP1

1 of 9

Yes

Atha\MKP2

1 of 9

Yes

Atha\PHS1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\MSG5

6 of 15

Yes

Scer\SDP1

6 of 15

Yes

Scer\PPS1

4 of 15

Yes

Scer\YVH1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pmp1

3 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BGC )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20632

Drosophila persimilis

Dper\GL24256

Drosophila willistoni

Dwil\GK14377

Drosophila virilis

Dvir\GJ24161

Drosophila mojavensis

Dmoj\GI23305

Drosophila grimshawi

Dgri\GH18324

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915074Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17010646

Glossina morsitans

Tsetse fly

Gmor\GMOY007515

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12789

Mayetiola destructor

Hessian fly

Mdes\Mdes000455

Mayetiola destructor

Hessian fly

Mdes\Mdes015144

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010411

Anopheles gambiae

Malaria mosquito

Agam\GPROR57

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008018

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07DR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis florea

Little honeybee

Aflo\2233727844

Apis mellifera

Western honey bee

Amel\GB44634

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18976

Bombus terrestris

Buff-tailed bumblebee

Bter\15216646

Linepithema humile

Argentine ant

Lhum\LH22171

Linepithema humile

Argentine ant

Lhum\LH22179

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0005af

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09081

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09080

Tribolium castaneum

Red flour beetle

Tcas\TC010766

Pediculus humanus

Human body louse

Phum\PHUM490910

Rhodnius prolixus

Kissing bug

Rpro\RPRC001918

Cimex lectularius

Bed bug

Clec\CLEC003273

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005391

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00473

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0B16 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR004509

Strigamia maritima

European centipede

Smar\SMAR015582

Ixodes scapularis

Black-legged tick

Isca\ISCW021412

Ixodes scapularis

Black-legged tick

Isca\ISCW011863

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77964.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g03710

Tetranychus urticae

Two-spotted spider mite

Turt\tetur25g00730

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g03740

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g01190

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_48778

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_23494

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0249 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ssh_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dusp14/18/21

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ssh

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Styx

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Jak_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dusp6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_016407gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dsp3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dsp6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dusp16

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dusp1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000009331

Ciona intestinalis

Vase tunicate

Cint\dusp1.2.4.5

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007989

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007532

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003538

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000005007

Gallus gallus

Domestic chicken

Ggal\DUSP6

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000011419

Gallus gallus

Domestic chicken

Ggal\DUSP19

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003706

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008581

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028155

Gallus gallus

Domestic chicken

Ggal\SSH2

Gallus gallus

Domestic chicken

Ggal\SSH1

Gallus gallus

Domestic chicken

Ggal\DUSP13

Gallus gallus

Domestic chicken

Ggal\DUSP26

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000029003

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026085

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000006647

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027641

Gallus gallus

Domestic chicken

Ggal\DUPD1

Gallus gallus

Domestic chicken

Ggal\DUSP18

Gallus gallus

Domestic chicken

Ggal\DUSP27

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

ssh

3 of 10

CG7378

2 of 10

Mkp

2 of 10

MKP-4

1 of 10

PTPMT1

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

puc^UAS.cMa

ameliorates rhabdoid cancer

modeled by Snr1^HMS00363, BacA\p35^UAS.cHa

(Xie et al., 2017)

ameliorates gastrointestinal adenoma

modeled by Apc^Q8, Apc2^g10

(Suijkerbuijk et al., 2016)

ameliorates cancer

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Ma et al., 2014)

modeled by Rab5^GD10492

(Ballesteros-Arias et al., 2014)

ameliorates neurodegenerative disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Tare et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DUSP10; dual specificity phosphatase 10

8 of 15

608867

DUSP8; dual specificity phosphatase 8

4 of 15

602038

DUSP16; dual specificity phosphatase 16

4 of 15

607175

DUSP1; dual specificity phosphatase 1

3 of 15

600714

DUSP4; dual specificity phosphatase 4

3 of 15

602747

DUSP14; dual specificity phosphatase 14

3 of 15

606618

DUSP18; dual specificity phosphatase 18

3 of 15

611446

DUSP28; dual specificity phosphatase 28

3 of 15

SSH2; slingshot protein phosphatase 2

3 of 15

606779

SSH3; slingshot protein phosphatase 3

3 of 15

606780

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

puc - p38b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

puc - rdx

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2009, Zhang et al., 2009, Zhuang et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Csk|puc

enhanceable

ASPP

(Langton et al., 2007)

suppressible

(Wu et al., 2009)

suppressible

(Wu et al., 2009)

suppressible

(Tang et al., 2013)

puc

suppressible

Atg12

(Tang et al., 2013)

gfr|puc

suppressible

bru3

(Beam and Moberg, 2010)

puc

suppressible

bsk

(Taniguchi et al., 2007, McEwen and Peifer, 2005, Wang et al., 2003, Sanyal et al., 2002)

flw|puc

suppressible

bsk

(Kirchner et al., 2007)

puc

suppressible

foxo

(Wang et al., 2005)

bi|puc

suppressible

(Adachi-Yamada and O'Connor, 2002)

suppressible

(Ren et al., 2017)

suppressible

(Adachi-Yamada et al., 1999)

puc

suppressible

hep

(Wang et al., 2003, Weber et al., 2000, Zeitlinger and Bohmann, 1999)

puc

suppressible

Jra

(Zhang et al., 2019)

puc

suppressible

kay

(Zhang et al., 2019)

egr|puc

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2009)

puc

suppressible

pan

(Zhang et al., 2019, Zhang et al., 2015)

enhanceable

(Cha et al., 2005)

suppressible

(Neisch et al., 2010)

Moe|puc

suppressible

Rho1

(Neisch et al., 2010)

puc

enhanceable

scaf

(Rousset et al., 2010)

puc

suppressible

sgg

(Zhang et al., 2015)

Moe|puc

suppressible

slpr

(Neisch et al., 2010)

flw|puc

suppressible

sqh

(Kirchner et al., 2007)

Moe|puc

suppressible

Tak1

(Neisch et al., 2010)

puc

suppressible

Traf6

(Tang et al., 2013)

puc

suppressible

(Zhang et al., 2019, Zhang et al., 2015)

flw|puc

suppressible

zip

(Kirchner et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Apc2|Apc

suppressible

puc

(Suijkerbuijk et al., 2016)

arm

suppressible

puc

(Cox et al., 2000, McEwen et al., 2000)

arm

enhanceable

puc

(McEwen et al., 2000)

arr

enhanceable

puc

(Giraldez and Cohen, 2003)

arr

suppressible

puc

(Giraldez and Cohen, 2003)

Atg9

suppressible

puc

(Tang et al., 2013)

Axud1

enhanceable

puc

(Glavic et al., 2009)

suppressible

puc

(del Alamo Rodriguez et al., 2004)

enhanceable

puc

(Adachi-Yamada et al., 1999)

brk

suppressible

puc

(Moreno et al., 2002)

bsk

suppressible

puc

(Wang et al., 2003)

chm

suppressible

puc

(Miotto et al., 2006)

crb

suppressible

puc

(Andersen et al., 2015)

Csk

enhanceable

puc

(Vidal et al., 2006)

Csk

suppressible

puc

(Vidal et al., 2006)

Daxx

suppressible

puc

(Hwang et al., 2013)

Dok

suppressible

puc

(Biswas et al., 2006)

dpp

enhanceable

puc

(Adachi-Yamada et al., 1999)

enhanceable

(Lim et al., 2012)

suppressible

(Andersen et al., 2015, Ma et al., 2012, Narasimamurthy et al., 2009, Moreno et al., 2002)

egr

enhanceable

puc

(Mallik and Lakhotia, 2009, Moreno et al., 2002)

FER

suppressible

puc

(Murray et al., 2006)

suppressible

(Ma et al., 2017)

enhanceable

(Padash-Barmchi et al., 2010)

enhanceable

puc

(Müller et al., 2005)

suppressible

(Nam et al., 2012)

enhanceable

(Baril et al., 2009, Zeitlinger and Bohmann, 1999)

hep

suppressible

puc

(Bosch et al., 2005, Wang et al., 2003, Agnes et al., 1999, Zeitlinger and Bohmann, 1999, Martin-Blanco et al., 1998)

hid

suppressible

puc

(Ryoo et al., 2004)

His1:CG31617

suppressible

puc

(Bayona-Feliu et al., 2017)

hppy

enhanceable

puc

(Resnik-Docampo and de Celis, 2011)

hppy

suppressible

puc

(Resnik-Docampo and de Celis, 2011)

suppressible

(Ha et al., 2005)

suppressible

(Sanyal et al., 2002)

kay

suppressible

puc

(Ramet et al., 2002, Zeitlinger and Bohmann, 1999)

knrl

suppressible

puc

(Gritzan et al., 2002)

l(2)gl

suppressible

puc

(Ma et al., 2013, Tamori et al., 2010)

suppressible

puc

(Singh et al., 2006)

suppressible

(Sun et al., 2019)

enhanceable

(Lee et al., 2006)

suppressible

(Tamori et al., 2010)

Moe

enhanceable

puc

(Neisch et al., 2010)

mol

suppressible

puc

(Khan et al., 2017)

Mrp4

suppressible

puc

(Huang et al., 2014)

Myc

suppressible

puc

(Moreno and Basler, 2004)

nab

suppressible

puc

(Suissa et al., 2011)

pan

suppressible

puc

(McEwen et al., 2000)

enhanceable

(Cha et al., 2005)

suppressible

(Wilk et al., 2004)

PSR

suppressible

puc

(Krieser et al., 2007)

Pvr

suppressible

puc

(Ishimaru et al., 2004)

Pvr

enhanceable

puc

(Mathieu et al., 2007)

Rab5

suppressible

puc

(Ballesteros-Arias et al., 2014)

Rab11

enhanceable

puc

(Tiwari and Roy, 2009)

Rab11

suppressible

puc

(Tiwari and Roy, 2009)

Rac1

enhanceable

puc

(Baril et al., 2009, Taniguchi et al., 2007, Stronach and Perrimon, 2002)

Rala

suppressible

puc

(Balakireva et al., 2006)

Rala

enhanceable

puc

(Balakireva et al., 2006)

Ras85D

suppressible

puc

(Ma et al., 2013, Uhlirova and Bohmann, 2006)

Ras85D

suppressible

puc|scrib

(Uhlirova and Bohmann, 2006)

Ras85D|l(2)gl

suppressible

puc

(Sun et al., 2019, Zhang et al., 2019, Ma et al., 2014, Ma et al., 2013, Ma et al., 2013)

Ras85D|scrib

suppressible

puc

(Uhlirova and Bohmann, 2006)

Rho1

enhanceable

puc

(Neisch et al., 2010)

Rho1

suppressible

puc

(Neisch et al., 2010)

suppressible

puc

(Martin-Blanco, 1998)

RpL7

suppressible

puc

(Colombani et al., 2012)

rpr

suppressible

puc

(Ryoo et al., 2004)

scrib

suppressible

puc

(Sun et al., 2019, Zhang et al., 2019)

enhanceable

puc

(Miotto et al., 2006)

sds22

suppressible

puc

(Jiang et al., 2011)

enhanceable

(Das et al., 2013)

suppressible

(Griswold et al., 2008)

slpr

suppressible

puc

(Baril et al., 2009, Polaski et al., 2006, Stronach and Perrimon, 2002)

slpr

enhanceable

puc

(Baril et al., 2009, Polaski et al., 2006)

suppressible

(Xie et al., 2017)

enhanceable

(Zhai et al., 2015)

Src42A

suppressible

puc

(Tateno et al., 2000)

Syx7

suppressible

puc

(Colombani et al., 2012)

tkv

enhanceable

puc

(Adachi-Yamada et al., 1999)

suppressible

puc

(Baena-Lopez and Garcia-Bellido, 2006)

Vha44

suppressible

puc

(Petzoldt et al., 2013)

Vps4

suppressible

puc

(Rodahl et al., 2009)

suppressible

puc

(McEwen et al., 2000)

enhanceable

puc

(McEwen et al., 2000)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66141

DroID - A comprehensive database of gene and protein interactions.

FBgn0243512

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40958

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84E12-84E11

Sequence location

3R:8,105,332..8,122,294 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84E12-84E11

Limits computationally determined from genome sequence between P{EP}EP3060^EP3060 and P{PZ}grn⁰⁵⁹³⁰; Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

84E-84E

(Martin-Blanco, 1998.1.12)

84E10-84E11

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

84F-84F

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997, Salzberg et al., 1997)

84E-84E

(determined by in situ hybridisation)

(Martin-Blanco et al., 1998, Ring and Martinez Arias, 1993)

84F1-84F2

(determined by in situ hybridisation)

(Salzberg et al., 1994)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.8

(Comeron et al., 2012)

3-47.6

(Salzberg et al., 1994)

Left of (cM)

(Kirchner et al., 2007)

Right of (cM)

(Kirchner et al., 2007)

Notes

Stocks and Reagents

Stocks (25)

Bloomington

20627

w^*; P{EPgy2}puc^EY09772/TM6C

31557

y¹ v¹; P{TRiP.JF01127}attP2

53019

y¹ v¹; P{TRiP.HMJ21742}attP40

56276

y¹ w^*; Mi{MIC}puc^MI11060

11173

P{lArB}puc^A251.1F3 ry⁵⁰⁶/TM3, Sb¹

FlyORF

F001556

M{UAS-puc.ORF}ZH-86Fb

F001235

M{UAS-puc.ORF.3xHA}ZH-86Fb

Kyoto

107559

puc¹ red¹ e⁴/TM3, Sb¹

109029

w^*; cno³ P{A92}puc^E69 / TM6B,abdA-LacZ

VDRC

v3019

w¹¹¹⁸ P{GD1515}v3019

v3018

w¹¹¹⁸; P{GD1515}v3018

v341126

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00146}attP40/CyO-GFP

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (72)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

SD08157

Other clones

DPiM_SD08157

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0243512

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0243512

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40958

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: puc CG7850

(Zhao, 1999.11)

Source for database merge of

Source for merge of: puc hrt

(Prokopenko et al., 2000)

Source for merge of: puc l(3)j4E1

(Kirchner et al., 2007)

Additional comments

Other Comments

dsRNA directed against puc inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.

(Bard et al., 2006)

dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

(Bard et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.

(Kiger et al., 2003)

Proper levels of puc activity in the follicle cells are critical for the production of a normal egg.

(Dobens et al., 2001)

Either reduced or increased puc activity results in incomplete nurse cell dumping and aberrant dorsal appendages.

(Dobens et al., 2001)

Mutations in puc, a known negative regulator of JNK signaling, suppress both the dorsal closure and ventral segment polarity defects associated with a decrease in wg signaling.

(McEwen et al., 2000)

puc normally antagonizes wg signalling in the ventral epidermis.

(McEwen et al., 2000)

Loss of function and gain of function mutants in puc cause planar polarity phenotypes in the eye.

(Weber et al., 2000)

hep controls puc expression but not dpp expression in imaginal discs.

(Agnes et al., 1999)

Candidate gene for quantitative trait (QTL) locus determining bristle number.

(Nuzhdin et al., 1999)

puc has a negative regulatory role in thorax closure during metamorphosis.

(Zeitlinger and Bohmann, 1999)

puc encodes a phosphatase that regulates signaling through the bsk pathway and participates in a negative feedback loop leading to a transient activity of the bsk signal during dorsal closure.

(Martin-Blanco et al., 1998)

puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.

(Glise and Noselli, 1997)

puc expression is regulated by bsk function.

(Riesgo-Escovar et al., 1996)

puc is negatively autoregulated in the follicle cells and that depression of puc in the squamous follicle cells at stage 10 is necessary for nurse cell transport.

(Dobens et al., 1995)

Ectopic expression of puc can cause defects in dorsal closure, dorsal puckering and denticle belt patterning. These phenotypes overlap those caused by loss of function alleles of puc.

(Gampel and Martinez Arias, 1995)

The General Council of the Velcro Group Corporation prohibited the use of the name 'velcro' for this gene, as that would constitute an infringement of trademark.

(Skaer, 1995.12.11)

Mutation in puc affects neuronal connections, affecting fasciculation.

(Salzberg et al., 1994)

puc is required for PNS development in the embryo.

(Salzberg et al., 1994)

Origin and Etymology

Discoverer

L. and Y. Jan.

Etymology

Identification

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40958

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0243512

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0243512

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

puc_1
puc_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7850

Flygut - An atlas of the Drosophila adult midgut

FBgn0243512

FlyMine - An integrated database for Drosophila genomics

FBgn0243512

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

205628

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40958

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010766

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7850

modMine - A data warehouse for the modENCODE project

FBgn0243512

Linkouts

BioGRID - A database of protein and genetic interactions.

66141

DPiM - Drosophila Protein interaction map

FBgn0243512

DroID - A comprehensive database of gene and protein interactions.

FBgn0243512

DRSC - Results frm RNAi screens

FBgn0243512

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0243512

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0243512

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40958

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

0238/03

(Deak et al., 1997)

1351/08

(Deak et al., 1997)

CG7850

(Yadav and Eleftherianos, 2019, Hosono et al., 2015, Kim et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Carrera et al., 2008, Ni et al., 2008, Quinones-Coello, 2007, Bard et al., 2006, Wheeler et al., 2004, De Gregorio et al., 2001, Morrison et al., 2000)

JNK-DSP

(Llense and Martín-Blanco, 2008)

PUC

(Sun et al., 2008, Xia and Karin, 2004)

PUC/MKP

(Morrison et al., 2000)

hrt

(Nuzhdin et al., 1999, Salzberg et al., 1997, Salzberg et al., 1994)

l(3)84Eh

(Ring and Martinez Arias, 1993, Baker et al., 1991)

l(3)A251.1

(Cox et al., 2000)

l(3)j4E1

puc

(Xu et al., 2020, Banerjee et al., 2019, Binh et al., 2019, Cai et al., 2019, Galenza and Foley, 2019, Hao et al., 2019, Hu and Jasper, 2019, Khan et al., 2019, Li et al., 2019, Ma et al., 2019, Pinal et al., 2019, Sanchez et al., 2019, Sun et al., 2019, Sun et al., 2019, Troha and Buchon, 2019, Wang et al., 2019, Wang et al., 2019, Yan et al., 2019, Zhang et al., 2019, Zhu et al., 2019, Ahmed-de-Prado and Baonza, 2018, Akagi et al., 2018, Bardai et al., 2018, Bushnell et al., 2018, Doupé et al., 2018, Dutta et al., 2018, Feng et al., 2018, Hao et al., 2018, Kumar and Tiwari, 2018, Luong et al., 2018, Mlih et al., 2018, Mondal et al., 2018, Palu and Chow, 2018, Paul et al., 2018, Pinal et al., 2018, Resende et al., 2018, Sarkar et al., 2018, Sharma et al., 2018, Wang et al., 2018, Wang et al., 2018, Yanku et al., 2018, Yu et al., 2018, Jordán-Álvarez et al., 2017, Lee et al., 2017, Liu and Jin, 2017, Ma et al., 2017, Ma et al., 2017, Ma et al., 2017, Martín et al., 2017, Rao and Rolls, 2017, Takemura and Nakato, 2017, Taylor et al., 2017, Wang et al., 2017, Xie et al., 2017, Xu et al., 2017, Zhou et al., 2017, Aggarwal et al., 2016, Agrawal et al., 2016, Bonfini et al., 2016, Calleja et al., 2016, Clandinin and Owens, 2016-, Deng et al., 2016, Diaz-Garcia et al., 2016, Li et al., 2016, Ma et al., 2016, Maistrenko et al., 2016, Tare et al., 2016, Voelzmann et al., 2016, Willsey et al., 2016, Yasin et al., 2016, Zhang et al., 2016, Álvarez-Fernández et al., 2015, Andersen et al., 2015, Chen et al., 2015, Doggett et al., 2015, Flores-Benitez and Knust, 2015, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Katsuyama et al., 2015, Kavi et al., 2015, Kim et al., 2015, Külshammer et al., 2015, Legent et al., 2015, Lim et al., 2015, Liu et al., 2015, Merino et al., 2015, Moreno et al., 2015, Ríos-Barrera et al., 2015, Srivastava, 2015, West et al., 2015, Wu et al., 2015, Yamamoto-Hino et al., 2015, Zaessinger et al., 2015, Zang et al., 2015, Zhai et al., 2015, Zhang et al., 2015, Zimmermann et al., 2015, Ashwal-Fluss et al., 2014, Ballard et al., 2014, Ballesteros-Arias et al., 2014, Brace et al., 2014, Fan et al., 2014, Handke et al., 2014, Herrera and Morata, 2014, Huang et al., 2014, Li et al., 2014, Okumura et al., 2014, Pereira et al., 2014, Ruiz et al., 2014, Sing et al., 2014, Sopko et al., 2014, Yanai et al., 2014, Bai et al., 2013, Bonke et al., 2013, Carter, 2013, Das et al., 2013, Herrera et al., 2013, Humphreys et al., 2013, Hwang et al., 2013, Klinedinst et al., 2013, Külshammer and Uhlirova, 2013, Langen et al., 2013, Losick et al., 2013, Macdonald et al., 2013, Ma et al., 2013, Ma et al., 2013, Owusu-Ansah et al., 2013, Pechkovsky et al., 2013, Perea et al., 2013, Pérez-Garijo et al., 2013, Petzoldt et al., 2013, Schertel et al., 2013, Sen et al., 2013, Tamori and Deng, 2013, Valakh et al., 2013, Vaque et al., 2013, Whitaker et al., 2013, Woodfield et al., 2013, Yang et al., 2013, Yin et al., 2013, Bangi et al., 2012, Belozerov et al., 2012, Chakrabarti et al., 2012, Chatterjee and Bohmann, 2012, Colombani et al., 2012, Eleftherianos and Castillo, 2012, Foronda et al., 2012, Gonda et al., 2012, Gowda et al., 2012, Jemc et al., 2012, Kapfhamer et al., 2012, Kelsey et al., 2012, Lada et al., 2012, Lim et al., 2012, Lu et al., 2012, Ma et al., 2012, Marchal et al., 2012, Meinander et al., 2012, Nam et al., 2012, Pezzulo et al., 2012, Poernbacher et al., 2012, Rynes et al., 2012, Abruzzi et al., 2011, Belacortu et al., 2011, Boyd et al., 2011, Glittenberg et al., 2011, Greenberg and Hatini, 2011, Huang et al., 2011, Jiang et al., 2011, Jiang et al., 2011, Marinho et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Opota et al., 2011, Repiso et al., 2011, Resnik-Docampo and de Celis, 2011, Rumpf et al., 2011, Seisenbacher et al., 2011, Tare et al., 2011, Tripura et al., 2011, Beam and Moberg, 2010, Bergantiños et al., 2010, Bergantiños et al., 2010, Bhuin and Roy, 2010, Bosch et al., 2010, Campos et al., 2010, Chen et al., 2010, Gettings et al., 2010, Lam et al., 2010, Lennox and Stronach, 2010, Li et al., 2010, Neisch et al., 2010, Okumura et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Rousset et al., 2010, Shaw et al., 2010, Singh et al., 2010, Sorrosal et al., 2010, Sun et al., 2010, Tamori et al., 2010, Umehara et al., 2010, Vidal et al., 2010, Wang and Ward, 2010, Wang et al., 2010, Warner et al., 2010, Wu et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Zhang et al., 2010, Apidianakis et al., 2009, Baril et al., 2009, Buchon et al., 2009, Cruz et al., 2009, Dichtel-Danjoy et al., 2009, Glavic et al., 2009, González et al., 2009, Hull-Thompson et al., 2009, Jiang et al., 2009, Mallik and Lakhotia, 2009, Massaro et al., 2009, McNamee and Brodsky, 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shen et al., 2009, Thevenon et al., 2009, Tiwari and Roy, 2009, Tuxworth et al., 2009, Umemori et al., 2009, Wu et al., 2009, Ziv et al., 2009, Bakal et al., 2008, Bates et al., 2008, Biteau et al., 2008, Bosch et al., 2008, Carrera et al., 2008, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Doheny et al., 2008, FlyBase Curators, 2008-, Grima et al., 2008, Griswold et al., 2008, Kleino et al., 2008, Libert et al., 2008, Llense and Martín-Blanco, 2008, Maillet et al., 2008, McNamee and Brodsky, 2008, Owusu-Ansah et al., 2008, Pastor-Pareja et al., 2008, Weber et al., 2008, Xi et al., 2008, Yoshioka et al., 2008, Avet-Rochex et al., 2007, Baeg et al., 2007, Bidla et al., 2007, Chen et al., 2007, Kankel et al., 2007, Kirchner et al., 2007, Krieser et al., 2007, Langton et al., 2007, Libert et al., 2007, Lin et al., 2007, Löw et al., 2007, Luo et al., 2007, Manjon et al., 2007, Neuman-Silberberg, 2007, Pfleger et al., 2007, Quinones-Coello, 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Umemori et al., 2007, Xue et al., 2007, Zeitlinger et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Balakireva et al., 2006, Cerrato et al., 2006, Delaney et al., 2006, Dionne et al., 2006, Friedman and Perrimon, 2006, Herz et al., 2006, Homsy et al., 2006, Hyun et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jordan et al., 2006, Lee et al., 2006, Murray et al., 2006, Polaski et al., 2006, Sato et al., 2006, Schimmelpfeng et al., 2006, Singh et al., 2006, Srahna et al., 2006, Tsuda et al., 2006, Uhlirova and Bohmann, 2006, Coffman et al., 2005, Gesellchen et al., 2005, Jordan et al., 2005, Lee et al., 2005, Mattila et al., 2005, McEwen and Peifer, 2005, Nelson et al., 2005, Tsuda et al., 2005, Pastor-Pareja et al., 2004, Ryoo et al., 2004, Wheeler et al., 2004, Cha et al., 2003, Jiang and Crews, 2003, Boutros et al., 2002, Sem et al., 2002)

puckered

(Agrawal et al., 2016)

vco

(Martinez Arias, 1993)

Name Synonyms

Jun N-terminal kinase dual-specificity phosphatase

(Llense and Martín-Blanco, 2008)

Velcro

(Skaer, 1995.12.11)

hearty

(Salzberg et al., 1994)

lethal (3) j4E1

puckered

(Jeong et al., 2018, Paul et al., 2018, Romey-Glüsing et al., 2018, Wang et al., 2018, Brace and DiAntonio, 2017, Lu et al., 2017, Muzzopappa et al., 2017, Takemura and Nakato, 2017, Whon et al., 2017, Yadav et al., 2017, Maistrenko et al., 2016, Katsuyama et al., 2015, Lim et al., 2015, Simon and Guerrero, 2015, Su, 2015, West et al., 2015, Yamamoto-Hino et al., 2015, Fernando et al., 2014, Handke et al., 2014, Pereira et al., 2014, Das et al., 2013, Herrera et al., 2013, Humphreys et al., 2013, Külshammer and Uhlirova, 2013, Losick et al., 2013, Macdonald et al., 2013, Ma et al., 2013, Owusu-Ansah et al., 2013, Pérez-Garijo et al., 2013, Tamori and Deng, 2013, Bangi et al., 2012, Colombani et al., 2012, Eleftherianos and Castillo, 2012, Foronda et al., 2012, Förster and Luschnig, 2012, Jemc et al., 2012, Lu et al., 2012, Meinander et al., 2012, Wang et al., 2012, Boyd et al., 2011, Jiang et al., 2011, Miles et al., 2011, Repiso et al., 2011, Beam and Moberg, 2010, Bergantiños et al., 2010, Bergantiños et al., 2010, Campos et al., 2010, Gettings et al., 2010, Lennox and Stronach, 2010, Li et al., 2010, Okumura et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Radyuk et al., 2010, Rousset et al., 2010, Tamori et al., 2010, Umehara et al., 2010, Vidal et al., 2010, Wang and Ward, 2010, Warner et al., 2010, Xiong et al., 2010, Buchon et al., 2009, Dichtel-Danjoy et al., 2009, Ha et al., 2009, Jiang et al., 2009, Mallik and Lakhotia, 2009, Massaro et al., 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shalaby et al., 2009, Shen et al., 2009, Wu et al., 2009, Bakal et al., 2008, Bates et al., 2008, Bosch et al., 2008, Doheny et al., 2008, Grima et al., 2008, Kleino et al., 2008, Llense and Martín-Blanco, 2008, Maillet et al., 2008, Melani et al., 2008, Owusu-Ansah et al., 2008, Weber et al., 2008, Yoshioka et al., 2008, Avet-Rochex et al., 2007, Kankel et al., 2007, Lee et al., 2007, Manjon et al., 2007, Mathieu et al., 2007, Neuman-Silberberg, 2007, Tadros et al., 2007, Taniguchi et al., 2007, Taniguchi et al., 2007, Xue et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Cerrato et al., 2006, Eissenberg, 2006, Homsy et al., 2006, Lee et al., 2006, Leulier et al., 2006, Sato et al., 2006, Tsuda et al., 2006, Jordan et al., 2005, Lee et al., 2005, Mattila et al., 2005, Nelson et al., 2005, Tsuda et al., 2005, Wang et al., 2004, Cha et al., 2003, Jiang and Crews, 2003, Kauppila et al., 2003, Martin-Blanco, 1998.1.12)

velcro

Secondary FlyBase IDs

FBgn0011600
FBgn0004210
FBgn0011369

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (638)