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Gene Dmel\eater

General Information
Symbol	Dmel\eater	Species	D. melanogaster
Name	eater	Annotation symbol	CG6124
Feature type	protein_coding_gene	FlyBase ID	FBgn0243514
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97E2-97E2	Sequence location	3R:22,921,589..22,925,401 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eater is referred to in FlyBase by the symbol Dmel\eater (CG6124, FBgn0243514). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Gram-positive bacterial cell surface binding; bacterial cell surface binding. There is experimental evidence that it is involved in the biological process: phagocytosis, recognition; lateral inhibition. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine rich repeat, tripleX; Epidermal growth factor-like; Growth factor, receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627746_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eater. Gene sequence location is 3R:22921589..22925401.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Transcripts eater-RC Polypeptides eater-PC
FB2012_01	Sequence features BKN31160
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97E2-97E2   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eater for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eater-RC FBtr0310079     3301   1074
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eater-PC   FBpp0301780   114.2   1074   4.95
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Growth factor, receptor (IPR009030) Epidermal growth factor-like (IPR006210) Cysteine rich repeat, tripleX (IPR003341)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567902   BI639730   BT011327
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VB78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0243514    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0243514 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0243514 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old  102 larva L3 puffstage 1-2  (285) larva L3 puffstage 3-6  (622) larva L3 puffstage 7-9  (400) white prepupae new  107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP  (392) pupae 4d postWPP    93 adult male 01day  103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0243514 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old  102 larva L3 puffstage 1-2  (285) larva L3 puffstage 3-6  (622) larva L3 puffstage 7-9  (400) white prepupae new  107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP  (392) pupae 4d postWPP    93 adult male 01day  103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    11 embryo 20-22hr    52 embryo 22-24hr    91 larva L1    53 larva L2    58 larva L3 12hr old    102 larva L3 puffstage 1-2    285 larva L3 puffstage 3-6    622 larva L3 puffstage 7-9    400 white prepupae new    107 white prepupae 12hr    29 white prepupae 24hr    24 pupae 2d postWPP    48 pupae 3d postWPP    392 pupae 4d postWPP    93 adult male 01day    103 adult male 05day    70 adult male 30day    22 adult female 01day    49 adult female 05day    31 adult female 30day    16 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0243514    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0243514 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0243514 expression level Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0243514 expression level Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.8 Larval Midgut    3.5 Larval Hindgut no informative data Larval Malpighian Tubules    44.5 Larval Fat Body    59.1 Larval Salivary Gland    1.9 Larval Trachea    58.6 Larval Carcass    154 Adult Head    55.3 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.9 Adult Midgut    1.4 Adult Hindgut    0.6 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    362.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    9.6 Adult Male Accessory Gland    1.9 Adult Carcass    78.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    55.3   NA  Eye    no informative data   NA  Brain    no informative data   1.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5.9   3.5  Midgut    1.4   no informative data  Hindgut    0.6   44.5  Malpighian Tubules    4.2   59.1  Fat Body    no informative data   1.9  Salivary Gland    no informative data   NA  Heart    362.8   58.6  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.9   NA  Testis    9.6   NA  Male Accessory Gland    1.9   154  Carcass    78.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0243514 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6124-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 eaterGD2618 Other Phenotypes Allele immune response defective eaterdsRNA.cKa immune response defective, with Scer\GAL4Hml.Δ eaterdsRNA.cKa visible, with Scer\GAL4pnr-MD237 eaterGD2618 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 eaterGD2618
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of eater Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eater Class Mutagen Stocks Known lesion eaterGD2618 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eaterScer\UAS.cKa in vitro construct - regulatory fusion 2 Yes eaterJF01884 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eater1-199.MtnA.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eaterdsRNA.cKa in vitro construct - RNAi 0 Yes eaterGD122 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes eaterGD14452 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)D605 (Kocks et al., 2005) Df(3R)Exel6206 (Ryder, 2004.4.26) Df(3R)Exel6207 (Ryder, 2004.4.26) Df(3R)Tl-I (Kocks et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD122} NA P{GD14452} NA P{TRiP.JF01884} NA P{UAS-eater.K} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
bacterial cell surface binding inferred from direct assay (Kocks et al., 2005) Gram-positive bacterial cell surface binding inferred from direct assay (Chung and Kocks, 2011)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) phagocytosis, recognition inferred from mutant phenotype (Kocks et al., 2005, Kocks et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eater allele Gene References unspecified PGRP-LC (Kocks et al., 2005) Sr-CI (Kocks et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0243514
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13719 LH25931 LH25929 FBgn0236385 FBgn0228444 FBgn0217030 FBgn0214047 FBgn0205327 FBgn0195310 FBgn0189639 FBgn0170370 FBgn0165085 FBgn0248034 FBgn0248032 FBgn0244626 FBgn0074844 FBgn0161205 FBgn0158847 FBgn0146003 FBgn0135448 FBgn0028939 FBgn0126417 FBgn0118612 FBgn0116044 FBgn0104433 FBgn0099947 FBgn0091302 CPIJ012711 CPIJ009517 CPIJ008236 BGIBMGA002383 GB14645 AGAP009763 AAEL007976 PB26791 GLEAN_15258 TC030481
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36324 w*; P{UAS-eater.K}3 36325 w*; P{UAS-eater.K}1 25863 y1 v1; P{TRiP.JF01884}attP2
VDRC	v4302 w1118 P{GD2618}v4302 v4301 w1118; P{GD2618}v4301
Genomic Clones ( 1 )
	BACR21O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD22390
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01967
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0243514 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43262
Antibody Information
	polyclonal (Chung and Kocks, 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: eater CG6124 (Kocks et al., 2005)
Additional comments
Other Comments
	S2 cells treated with dsRNA directed against eater show decreased uptake of S.aureus by phagocytosis compared to control cells. (Stuart et al., 2007) Silencing of eater in S2 cells results in a strong decrease in phagocytosis of both Gram-positive and Gram-negative bacteria in these cells. The defect is in the recognition and binding of the pathogens. (Kocks et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AA567902 AAF56664 BI639730 Entrez Gene - A searchable database of RefSeq genes. • 43262 UniProtKB/TrEMBL • Q9VB78
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Growth factor, receptor (IPR009030) Epidermal growth factor-like (IPR006210) Cysteine rich repeat, tripleX (IPR003341)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0243514 DRSC - Results from RNAi screens. • FBgn0243514 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0243514 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6124-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0243514 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43262 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/eaterandnimrod.htm modMine - Data generated by the modENCODE project. • FBgn0243514 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13719 LH25931 LH25929 FBgn0236385 FBgn0228444 FBgn0217030 FBgn0214047 FBgn0205327 FBgn0195310 FBgn0189639 FBgn0170370 FBgn0165085 FBgn0248034 FBgn0248032 FBgn0244626 FBgn0074844 FBgn0161205 FBgn0158847 FBgn0146003 FBgn0135448 FBgn0028939 FBgn0126417 FBgn0118612 FBgn0116044 FBgn0104433 FBgn0099947 FBgn0091302 CPIJ012711 CPIJ009517 CPIJ008236 BGIBMGA002383 GB14645 AGAP009763 AAEL007976 PB26791 GLEAN_15258 TC030481
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	C901-like (Hynes and Zhao, 2000) CG6124 (Kocks et al., 2005, Stuart et al., 2007, Kurucz et al., 2007, Perkins et al., 1.15.2009, Carrera et al., 2008, Douglas et al., 2011) CT19227 (Hynes and Zhao, 2000) Eater (Brennan et al., 2007, Fernández-Ayala et al., 2010, Douglas et al., 2011) eater (Erturk-Hasdemir and Silverman, 2005, Kocks et al., 2005, Ulvila et al., 2006, Tokusumi et al., 2009, Carrera et al., 2008, Honti et al., 2010, Chamilos et al., 2008, Sackton et al., 2007, Akbar et al., 2011, Charroux and Royet, 2009, Igboin et al., 2011)
Name Synonym	CG6124   eater (Kocks et al., 2005, Stuart et al., 2007, Tokusumi et al., 2009, Perrimon and Mathey-Prevot, 2007, Kocks et al., 2005, Ye et al., 2009, Charroux and Royet, 2009, Sorrentino et al., 2007) Eater (Cho and Kocks, 2007, Kurucz et al., 2007, Kurucz et al., 2007, Rocha et al., 2011)
Secondary FlyBase IDs
	FBgn0039484 FBgn0082595
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 7 )
	Akbar et al., 2011, J. Cell Biol. 192(3): 383--390 The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. [FBrf0212933] Chung and Kocks, 2011, J. Biol. Chem. 286(30): 26524--26532 Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor eater. [FBrf0214502] Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Igboin et al., 2011, Infect. Immun. 79(1): 449--458 Porphyromonas gingivalis-Host Interactions in a Drosophila melanogaster Model. [FBrf0212619] Rocha et al., 2011, PLoS ONE 6(4): e19087 A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi. [FBrf0213678] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Honti et al., 2010, Molec. Immunol. 47(11-12): 1997--2004 Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster. [FBrf0211151] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...