FlyBase Gene Report: Dmel\eater

General Information

Symbol

Dmel\eater

Species

D. melanogaster

Name

eater

Annotation Symbol

CG6124

Feature Type

protein_coding_gene

FlyBase ID

FBgn0243514

Gene Model Status

Stock Availability

11 publicly available

Gene Snapshot

eater (eater) encodes a transmembrane receptor of the Nimrod family specifically expressed in hemocytes and required for the phagocytosis of Gram positive bacteria and the attachment of hemocytes to sessile niches. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:27,095,867..27,099,679 [-]

Recombination map

3-92

RefSeq locus

NT_033777 REGION:27095867..27099679

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables peptidoglycan binding

inferred from direct assay

(Chung and Kocks, 2011)

enables scavenger receptor activity

inferred from direct assay

(Kocks et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in defense response to bacterium

inferred from mutant phenotype

(Hashimoto et al., 2009, Kocks et al., 2005)

involved_in defense response to Gram-positive bacterium

inferred from mutant phenotype

(Bretscher et al., 2015)

involved_in immune response

inferred from mutant phenotype

(Christofi and Apidianakis, 2013)

involved_in phagocytosis, recognition

inferred from mutant phenotype

(Kocks et al., 2005)

involved_in phagocytosis

inferred from mutant phenotype

(Hashimoto et al., 2009)

involved_in positive regulation of cell-substrate adhesion

inferred from mutant phenotype

(Bretscher et al., 2015)

involved_in positive regulation of phagocytosis

inferred from mutant phenotype

(Bretscher et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Chung and Kocks, 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Kocks et al., 2005)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\eater for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.43

Gene model reviewed during 5.42

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0310079

3301

1074

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0301780

114.2

1074

4.95

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VB78

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eater using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eater_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval lymph gland

(Kocks et al., 2005)

(Kocks et al., 2005)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

(Kocks et al., 2005)

pharate adult stage

(Kocks et al., 2005)

Additional Descriptive Data

eater transcript can be detected in wandering third instar larvae, and in pharate adults, but not at prepupal or pupal stages. eater transcript is expressed in all lobes of the lymph gland, and in all plasmatocyte lineage cells including circulating and sessile plasmatocytes and macrophages, but not crystal cells or lamellocytes. eater transcript is not detected in any nonhematopoietic larval tissues, nor in embryonic macrophages.

(Kocks et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Chung and Kocks, 2011)

Expression Deduced from Reporters

Reporter: P{eater-DsRed.K}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval lymph gland

(Kroeger et al., 2012)

cortical zone of lymph gland primary lobe

(Kroeger et al., 2012)

second instar larval stage -- third instar larval stage

(Kroeger et al., 2012)

(Kroeger et al., 2012)

Reporter: P{eater-GAL4.K}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval lymph gland

(Kocks, 2011.9.29)

embryonic/larval hemocyte

(Kocks, 2011.9.29)

larval stage -- adult stage

lymph gland derived hemocyte

(Kocks, 2011.9.29)

Reporter: P{eater-GAL4.T}

Stage

Tissue/Position (including subcellular localization)

Reference

(Honti et al., 2010)

third instar larval stage

(Tokusumi et al., 2009)

cortical zone of lymph gland primary lobe

Comment: 96-120 hr AEL

(Kroeger et al., 2012, Tokusumi et al., 2009)

second instar larval stage -- third instar larval stage

Comment: 48-120 hr AEL

(Kroeger et al., 2012)

Reporter: P{eater-GFP.1.7}

Stage

Tissue/Position (including subcellular localization)

Reference

late third instar larval stage

embryonic/larval lymph gland

(Kroeger et al., 2012)

cortical zone of lymph gland primary lobe

(Kroeger et al., 2012)

secondary lobe of embryonic/larval lymph gland

(Kroeger et al., 2012)

tertiary lobe of embryonic/larval lymph gland

(Kroeger et al., 2012)

(Kroeger et al., 2012)

Comment: sessile and circulating

(Kroeger et al., 2012)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eater in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eater

View exonic expression by tissue for Dmel\eater

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0243514

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6124-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6124

Flygut - An atlas of the Drosophila adult midgut

FBgn0243514

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eater

Transgenic constructs containing regulatory region of eater

Deletions and Duplications ( 4 )

Disrupted in

(Kocks et al., 2005)

(Ryder, 2004.4.26)

(Ryder, 2004.4.26)

(Kocks et al., 2005)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

eater^GD2618

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

eater^GD2618

viable, with Scer\GAL4^tin.CΔ4

eater^GD2618

Other Phenotypes

Allele

immune response defective

eater^unspecified

immune response defective, with Scer\GAL4^Hml.Δ

eater^{dsRNA.UAS.cUa}

visible, with Scer\GAL4^pnr-MD237

eater^GD2618

Phenotype manifest in

Allele

chaeta | supernumerary, with Scer\GAL4^pnr-MD237

eater^GD2618

crystal cell | third instar larval stage

eater¹

crystal cell | third instar larval stage, with Scer\GAL4^Hml.Δ

eater^NIG.6124R

embryonic/larval hemocyte

eater¹

sessile hemocyte | somatic clone | third instar larval stage

eater¹

sessile hemocyte | third instar larval stage

eater¹

sessile hemocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

eater^NIG.6124R

sessile hemocyte | third instar larval stage (with Df(3R)BSC791)

eater¹

sessile hemocyte | third instar larval stage (with Df(3R)Exel6206)

eater¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1

1 of 15

Yes

No

1

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

Rattus norvegicus (Norway rat) (17)

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

Rnor\LOC100911486

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

No

Xenopus tropicalis (Western clawed frog) (11)

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

No

1 of 12

Yes

No

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

Danio rerio (Zebrafish) (25)

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

Drer\zgc:158328

1 of 15

Yes

No

Caenorhabditis elegans (Nematode, roundworm) (27)

2 of 15

Yes

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901UW )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00009187

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915011S )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY007487

Glossina morsitans

Tsetse fly

Gmor\GMOY003159

Glossina morsitans

Tsetse fly

Gmor\GMOY003160

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00052

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00048

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00054

Mayetiola destructor

Hessian fly

Mdes\Mdes012145

Anopheles darlingi

American malaria mosquito

Adar\ADAC000126

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009517

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008236

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012711

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00UJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002383

Danaus plexippus

Monarch butterfly

Dple\DPOGS210252-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS210251-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008031

Heliconius melpomene

Postman butterfly

Hmel\HMEL014654

Heliconius melpomene

Postman butterfly

Hmel\HMEL008030

Heliconius melpomene

Postman butterfly

Apis florea

Little honeybee

Aflo\2147496819

Apis florea

Little honeybee

Aflo\2147496803

Apis florea

Little honeybee

Aflo\2354232276

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002c86

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008002

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008001

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Rhodnius prolixus

Kissing bug

Rpro\RPRC004307

Rhodnius prolixus

Kissing bug

Rpro\RPRC004336

Cimex lectularius

Bed bug

Clec\CLEC003712

Cimex lectularius

Bed bug

Clec\CLEC003710

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00565

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07456

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13417

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11982

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03M1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003283gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004359gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006982gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fibcd1_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027541gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Egfia_6

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000817gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_001373gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_002719gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021409gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_009605gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_009606gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012578gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Egf/Ccp

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_023633gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Angptl1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012412gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fibcd1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Angptl1

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027213gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1727

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004342gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Egf/Lnb/7Tm/Gpcr_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017720gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Notch2L_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027542gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Wap/Wap_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_010834gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Wap/Ty/Egf

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fibcd1_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_024361gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006151gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004928gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fbg/Egf/Clect

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2964

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006981gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022729gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_023222gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Angptl1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_016984gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006980gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1661

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019802

Ciona intestinalis

Vase tunicate

Cint\LOC100182094

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021405

Ciona intestinalis

Vase tunicate

Cint\LOC100179852

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000010151

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019153

Ciona intestinalis

Vase tunicate

Cint\LOC100184314

Ciona intestinalis

Vase tunicate

Cint\LOC100178407

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021992

Ciona intestinalis

Vase tunicate

Cint\LOC100176826

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001531

Ciona intestinalis

Vase tunicate

Cint\LOC100177187

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003482

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005497

Ciona intestinalis

Vase tunicate

Cint\LOC100183414

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000023637

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Cint\LOC100178409

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012917

Ciona intestinalis

Vase tunicate

Cint\LOC100175128

Ciona intestinalis

Vase tunicate

Cint\LOC100178820

Ciona intestinalis

Vase tunicate

Cint\LOC100179147

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000023980

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018658

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019770

Ciona intestinalis

Vase tunicate

Cint\LOC100184033

Ciona intestinalis

Vase tunicate

Cint\LOC100183808

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022245

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012948

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019392

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024396

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021970

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007113

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026890

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\angiopoietin-2

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000009151

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000006832

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027520

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

eater^unspecified

model of bacterial infectious disease

CEA

(Christofi and Apidianakis, 2013)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Csordás et al., 2020)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0243514

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-92

Cytogenetic map

Sequence location

3R:27,095,867..27,099,679 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97E2-97E2

Limits computationally determined from genome sequence between P{PZ}sda⁰³⁸⁸⁴ and P{PZ}btz^rL203

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-92

(FlyBase, 2016)

3-89.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

36324

w^*; P{UAS-eater.K}3

36325

w^*; P{UAS-eater.K}1

36321

w¹¹¹⁸; P{eater-GAL4.K}3-1

36322

w¹¹¹⁸; P{eater-GAL4.K}3-2

68388

w^*; TI{TI}eater¹

25863

y¹ v¹; P{TRiP.JF01884}attP2

63959

w¹¹¹⁸; PBac{IT.GAL4}eater^1010-G4

61081

y¹ w^*; Mi{MIC}eater^MI15531

v4302

w¹¹¹⁸ P{GD2618}v4302

v4301

w¹¹¹⁸; P{GD2618}v4301

v342571

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02274}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD22390

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0243514

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

HL01967

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0243514

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43262

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Chung and Kocks, 2011)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: eater CG6124

(Kocks et al., 2005)

Additional comments

Other Comments

S2 cells treated with dsRNA directed against eater show decreased uptake of S.aureus by phagocytosis compared to control cells.

(Stuart et al., 2007)

Silencing of eater in S2 cells results in a strong decrease in phagocytosis of both Gram-positive and Gram-negative bacteria in these cells. The defect is in the recognition and binding of the pathogens.

(Kocks et al., 2005)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 23 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43262

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF56664

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VB78

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0243514

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eater_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6124

Flygut - An atlas of the Drosophila adult midgut

FBgn0243514

FlyMine - An integrated database for Drosophila genomics

FBgn0243514

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43262

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031640

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6124

modMine - A data warehouse for the modENCODE project

FBgn0243514

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0243514

DRSC - Results frm RNAi screens

FBgn0243514

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0243514

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6124-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0243514

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

C901-like

(Hynes and Zhao, 2000)

CG6124

(Okuda et al., 2016, Palu and Thummel, 2016, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Douglas et al., 2011, Perkins et al., 2009.1.15, Carrera et al., 2008, Kurucz et al., 2007, Stuart et al., 2007, Kocks et al., 2005)

CT19227

(Hynes and Zhao, 2000)

Dmel_CG6124

(Radyuk et al., 2012)

Eater

(Vlisidou and Wood, 2015, Péan and Dionne, 2014, Wang et al., 2014, Bier and Guichard, 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Longworth et al., 2012, Douglas et al., 2011, Fernández-Ayala et al., 2010, Brennan et al., 2007)

eater

(Csordás et al., 2020, Lu et al., 2020, Ramond et al., 2020, Ramond et al., 2020, Asri et al., 2019, Banerjee et al., 2019, Dudzic et al., 2019, Leech et al., 2019, Melcarne et al., 2019, Sinha et al., 2019, Troha and Buchon, 2019, Abhyankar et al., 2018, Hao et al., 2018, Yu et al., 2018, Clandinin and Owens, 2016-, Bretscher et al., 2015, Evans et al., 2014, Honti et al., 2014, Christofi and Apidianakis, 2013, Kroeger et al., 2013, Hamilos et al., 2012, Kroeger et al., 2012, Paré et al., 2012, Akbar et al., 2011, Gonsalves et al., 2011, Igboin et al., 2011, Nehme et al., 2011, Ulvila et al., 2011, Ye and McGraw, 2011, Honti et al., 2010, Juneja and Lazzaro, 2010, Somogyi et al., 2010, Stofanko et al., 2010, Charroux and Royet, 2009, Hashimoto et al., 2009, Tokusumi et al., 2009, Carrera et al., 2008, Chamilos et al., 2008, Sackton et al., 2007, Ulvila et al., 2006, Erturk-Hasdemir and Silverman, 2005, Kocks et al., 2005)

Name Synonyms

CG6124

Eater

(Yu et al., 2018, Parsons and Foley, 2016, Arefin et al., 2014, Rocha et al., 2011, Defaye et al., 2009, Cho and Kocks, 2007, Kurucz et al., 2007, Kurucz et al., 2007)

eater

(Cho et al., 2020, Vanha-Aho et al., 2012, Charroux and Royet, 2009, Hashimoto et al., 2009, Tokusumi et al., 2009, Ye et al., 2009, Perrimon and Mathey-Prevot, 2007, Sorrentino et al., 2007, Stuart et al., 2007, Kocks et al., 2005, Kocks et al., 2005)

Secondary FlyBase IDs

FBgn0082595
FBgn0039484

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (102)