FB2019_06, released Dec 19, 2019

Gene: Dmel\eater

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General Information
Symbol
Dmel\eater
Species
D. melanogaster
Name
eater
Annotation Symbol
CG6124
Feature Type
protein_coding_gene
FlyBase ID
FBgn0243514
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
eater (eater) encodes a transmembrane receptor of the Nimrod family specifically expressed in hemocytes and required for the phagocytosis of Gram positive bacteria and the attachment of hemocytes to sessile niches. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
97E2-97E2
Sequence location
3R:27,095,867..27,099,679 [-]
Recombination map
3-92
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
peptidoglycan binding; scavenger receptor activity
Predictions / Assertions
-
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\eater or the JBrowse view of Dmel\eater for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Gene model reviewed during 5.43
Gene model reviewed during 5.42
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eater-RC
FBtr0310079
NM_143276
3301
1074
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
eater-PC
FBpp0301780
114.2
1074
4.95
NP_651533
AAF56664
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eater using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
peptidoglycan binding
inferred from direct assay
(Chung and Kocks, 2011)
scavenger receptor activity
inferred from direct assay
(Kocks et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
defense response to bacterium
inferred from mutant phenotype
(Hashimoto et al., 2009, Kocks et al., 2005)
defense response to Gram-positive bacterium
inferred from mutant phenotype
(Bretscher et al., 2015)
immune response
inferred from mutant phenotype
(Christofi and Apidianakis, 2013)
phagocytosis
inferred from mutant phenotype
(Hashimoto et al., 2009)
phagocytosis, recognition
inferred from mutant phenotype
(Kocks et al., 2005)
positive regulation of cell-substrate adhesion
inferred from mutant phenotype
(Bretscher et al., 2015)
positive regulation of phagocytosis
inferred from mutant phenotype
(Bretscher et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cell surface
inferred from direct assay
(Chung and Kocks, 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of membrane
inferred from sequence model
(Kocks et al., 2005)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval lymph gland
(Kocks et al., 2005)
plasmatocyte
(Kocks et al., 2005)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
organism
(Kocks et al., 2005)
pharate adult stage
organism
(Kocks et al., 2005)
Additional Descriptive Data
eater transcript can be detected in wandering third instar larvae, and in pharate adults, but not at prepupal or pupal stages. eater transcript is expressed in all lobes of the lymph gland, and in all plasmatocyte lineage cells including circulating and sessile plasmatocytes and macrophages, but not crystal cells or lamellocytes. eater transcript is not detected in any nonhematopoietic larval tissues, nor in embryonic macrophages.
(Kocks et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cell surface
inferred from direct assay
(Chung and Kocks, 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eater in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eater
Transgenic constructs containing regulatory region of eater
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ANGPT1
1 of 15
Yes
No
Hsap\ANGPT2
1 of 15
Yes
No
Hsap\ANGPT4
1 of 15
Yes
No
Hsap\ANGPTL1
1 of 15
Yes
No
Hsap\ANGPTL2
1 of 15
Yes
No
Hsap\ANGPTL3
1 of 15
Yes
No
Hsap\ANGPTL4
1 of 15
Yes
No
Hsap\ANGPTL5
1 of 15
Yes
No
Hsap\ANGPTL6
1 of 15
Yes
No
Hsap\ANGPTL7
1 of 15
Yes
No
Hsap\DKK2
1 of 15
Yes
Yes
Hsap\FCN2
1 of 15
Yes
No
Hsap\FCN3
1 of 15
Yes
No
Hsap\FGA
1 of 15
Yes
No
 
Hsap\FGB
1 of 15
Yes
No
 
Hsap\FGL1
1 of 15
Yes
No
Hsap\FGL2
1 of 15
Yes
No
Hsap\FIBCD1
1 of 15
Yes
No
Hsap\MEGF6
1 of 15
Yes
No
Hsap\MEGF10
1 of 15
Yes
No
Hsap\MEGF11
1 of 15
Yes
No
 
Hsap\PEAR1
1 of 15
Yes
No
 
Hsap\SCARF1
1 of 15
Yes
No
Hsap\SCARF2
1 of 15
Yes
No
Hsap\SCUBE1
1 of 15
Yes
No
Hsap\SCUBE2
1 of 15
Yes
No
Hsap\SCUBE3
1 of 15
Yes
No
Hsap\TNC
1 of 15
Yes
No
Hsap\TNFAIP6
1 of 15
Yes
Yes
Hsap\TNN
1 of 15
Yes
No
Hsap\TNR
1 of 15
Yes
No
Hsap\VEGFC
1 of 15
Yes
No
Hsap\VEGFD
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (37)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Angpt1
1 of 15
Yes
No
Mmus\Angpt2
1 of 15
Yes
No
Mmus\Angpt4
1 of 15
Yes
No
Mmus\Angptl1
1 of 15
Yes
No
Mmus\Angptl2
1 of 15
Yes
No
Mmus\Angptl3
1 of 15
Yes
No
Mmus\Angptl6
1 of 15
Yes
No
Mmus\Angptl7
1 of 15
Yes
No
Mmus\Dkk2
1 of 15
Yes
Yes
Mmus\Dkk3
1 of 15
Yes
Yes
Mmus\Egfem1
1 of 15
Yes
Yes
Mmus\Esm1
1 of 15
Yes
Yes
Mmus\Fcna
1 of 15
Yes
No
Mmus\Fcnb
1 of 15
Yes
No
Mmus\Fga
1 of 15
Yes
No
Mmus\Fgb
1 of 15
Yes
No
Mmus\Fgg
1 of 15
Yes
No
Mmus\Fgl1
1 of 15
Yes
No
Mmus\Fgl2
1 of 15
Yes
No
Mmus\Fibcd1
1 of 15
Yes
No
Mmus\Megf6
1 of 15
Yes
No
Mmus\Megf10
1 of 15
Yes
No
Mmus\Megf11
1 of 15
Yes
No
Mmus\Mfap4
1 of 15
Yes
No
Mmus\Pear1
1 of 15
Yes
No
Mmus\Scarf1
1 of 15
Yes
No
Mmus\Scube1
1 of 15
Yes
No
Mmus\Scube2
1 of 15
Yes
No
Mmus\Scube3
1 of 15
Yes
No
Mmus\Stab1
1 of 15
Yes
Yes
Mmus\Tnc
1 of 15
Yes
No
Mmus\Tnfaip6
1 of 15
Yes
Yes
Mmus\Tnn
1 of 15
Yes
No
Mmus\Tnr
1 of 15
Yes
No
Mmus\Tnxb
1 of 15
Yes
No
Mmus\Vegfc
1 of 15
Yes
No
Mmus\Vegfd
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (32)
Rnor\Angpt2
1 of 13
Yes
No
Rnor\Angpt4
1 of 13
Yes
No
Rnor\Angptl1
1 of 13
Yes
No
Rnor\Angptl3
1 of 13
Yes
No
Rnor\Angptl4
1 of 13
Yes
No
Rnor\Dkk2
1 of 13
Yes
Yes
Rnor\Esm1
1 of 13
Yes
Yes
Rnor\Fcna
1 of 13
Yes
No
Rnor\Fcnb
1 of 13
Yes
No
Rnor\Fga
1 of 13
Yes
No
Rnor\Fgb
1 of 13
Yes
No
Rnor\Fgg
1 of 13
Yes
No
Rnor\Fgl1
1 of 13
Yes
No
Rnor\Fgl2
1 of 13
Yes
No
Rnor\Fibcd1l1
1 of 13
Yes
No
Rnor\LOC100911486
1 of 13
Yes
No
Rnor\LOC102552055
1 of 13
Yes
No
Rnor\LOC102553715
1 of 13
Yes
No
Rnor\Megf6
1 of 13
Yes
Yes
Rnor\Megf10
1 of 13
Yes
No
Rnor\Megf11
1 of 13
Yes
No
Rnor\Mfap4
1 of 13
Yes
No
Rnor\Pear1
1 of 13
Yes
No
Rnor\Scarf2
1 of 13
Yes
No
Rnor\Scube2
1 of 13
Yes
No
Rnor\Scube3
1 of 13
Yes
No
Rnor\Stab1
1 of 13
Yes
Yes
Rnor\Tnc
1 of 13
Yes
No
Rnor\Tnfaip6
1 of 13
Yes
Yes
Rnor\Tnn
1 of 13
Yes
No
Rnor\Tnr
1 of 13
Yes
No
Rnor\Vegfc
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\angptl1
1 of 12
Yes
Yes
Xtro\angptl7
1 of 12
Yes
No
Xtro\fcn3
1 of 12
Yes
No
Xtro\fgb
1 of 12
Yes
No
Xtro\fgg
1 of 12
Yes
No
Xtro\fgl1
1 of 12
Yes
No
Xtro\fgl2
1 of 12
Yes
No
Xtro\megf11
1 of 12
Yes
No
Xtro\scube1
1 of 12
Yes
No
Xtro\stab2
1 of 12
Yes
Yes
Xtro\tnfaip6
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (52)
Drer\angpt1
1 of 15
Yes
No
Drer\angpt2a
1 of 15
Yes
No
Drer\angpt2b
1 of 15
Yes
No
Drer\angpt4
1 of 15
Yes
No
Drer\angptl1a
1 of 15
Yes
No
Drer\angptl1b
1 of 15
Yes
No
Drer\angptl2a
1 of 15
Yes
No
Drer\angptl2b
1 of 15
Yes
No
Drer\angptl3
1 of 15
Yes
No
Drer\angptl5
1 of 15
Yes
No
Drer\angptl6
1 of 15
Yes
No
Drer\angptl7
1 of 15
Yes
No
Drer\ccbe1
1 of 15
Yes
Yes
Drer\dkk1a
1 of 15
Yes
Yes
Drer\dkk2
1 of 15
Yes
Yes
Drer\esm1
1 of 15
Yes
Yes
Drer\fga
1 of 15
Yes
No
Drer\fgb
1 of 15
Yes
No
Drer\fgg
1 of 15
Yes
No
Drer\fgl2a
1 of 15
Yes
No
Drer\fgl2b
1 of 15
Yes
No
Drer\fibcd1
1 of 15
Yes
No
Drer\LOC100007488
1 of 15
Yes
No
Drer\ltbp3
1 of 15
Yes
No
Drer\megf6a
1 of 15
Yes
No
Drer\megf6b
1 of 15
Yes
No
Drer\megf10
1 of 15
Yes
No
Drer\megf11
1 of 15
Yes
No
Drer\mfap4
1 of 15
Yes
No
Drer\pear1
1 of 15
Yes
No
Drer\scarf1
1 of 15
Yes
No
Drer\scube1
1 of 15
Yes
No
Drer\scube2
1 of 15
Yes
Yes
Drer\scube3
1 of 15
Yes
No
Drer\si:ch211-157b11.8
1 of 15
Yes
No
Drer\si:ch211-203k16.3
1 of 15
Yes
No
Drer\si:ch211-287a12.9
1 of 15
Yes
No
Drer\si:ch1073-110a20.1
1 of 15
Yes
No
Drer\si:ch1073-110a20.2
1 of 15
Yes
No
Drer\si:ch1073-110a20.3
1 of 15
Yes
No
Drer\si:zfos-2330d3.1
1 of 15
Yes
No
Drer\si:zfos-2330d3.8
1 of 15
Yes
No
Drer\tnc
1 of 15
Yes
No
Drer\tnfaip6
1 of 15
Yes
Yes
Drer\tnn
1 of 15
Yes
No
Drer\vegfab
1 of 15
Yes
No
Drer\vegfc
1 of 15
Yes
No
Drer\vegfd
1 of 15
Yes
Yes
Drer\wu:fj11g02
1 of 15
Yes
No
Drer\zgc:158328
1 of 15
Yes
No
Drer\zgc:173915
1 of 15
Yes
No
Drer\zmp:0000000846
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (36)
Cele\abu-4
1 of 15
Yes
Yes
Cele\abu-10
1 of 15
Yes
Yes
Cele\arg-1
1 of 15
Yes
No
Cele\C08G9.2
1 of 15
Yes
No
Cele\C49C8.5
1 of 15
Yes
No
Cele\C53B7.2
1 of 15
Yes
No
Cele\ced-1
1 of 15
Yes
No
Cele\D1044.7
1 of 15
Yes
No
Cele\dsl-1
1 of 15
Yes
Yes
Cele\dsl-2
1 of 15
Yes
Yes
Cele\dsl-3
1 of 15
Yes
Yes
Cele\dsl-5
1 of 15
Yes
Yes
Cele\dsl-6
1 of 15
Yes
Yes
Cele\dsl-7
1 of 15
Yes
Yes
Cele\ensh-1
1 of 15
Yes
No
Cele\F07H5.8
1 of 15
Yes
No
Cele\F35A5.4
1 of 15
Yes
No
Cele\F46B3.15
1 of 15
Yes
Yes
Cele\far-5
1 of 15
Yes
Yes
Cele\K10D3.4
1 of 15
Yes
No
Cele\lag-2
1 of 15
Yes
Yes
Cele\M195.2
1 of 15
Yes
Yes
Cele\pqn-13
1 of 15
Yes
No
Cele\pqn-25
1 of 15
Yes
No
Cele\sdz-23
1 of 15
Yes
Yes
Cele\str-90
1 of 15
Yes
Yes
Cele\T01D3.3
1 of 15
Yes
Yes
Cele\T15B7.1
1 of 15
Yes
No
Cele\W05B2.2
1 of 15
Yes
No
Cele\Y26D4A.12
1 of 15
Yes
No
Cele\Y41D4B.26
1 of 15
Yes
Yes
Cele\Y43C5A.2
1 of 15
Yes
No
Cele\Y64G10A.7
1 of 15
Yes
No
Cele\Y69H2.3
1 of 15
Yes
Yes
Cele\Y69H2.10
1 of 15
Yes
Yes
Cele\ZC504.1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901UW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\eater
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009187
Drosophila simulans
Dsim\GD18096
Drosophila sechellia
Dsec\GM10134
Drosophila erecta
Dere\GG12141
Drosophila erecta
Dere\GG26307
Drosophila yakuba
Dyak\GE10589
Drosophila ananassae
Dana\GF27586
Drosophila ananassae
Dana\GF22953
Drosophila pseudoobscura pseudoobscura
Dpse\GA23224
Drosophila persimilis
Dper\GL23615
Drosophila willistoni
Dwil\GK12036
Drosophila virilis
Dvir\GJ24134
Drosophila grimshawi
Dgri\GH18950
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915011S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011062
Musca domestica
House fly
Mdoa\17004255
Musca domestica
House fly
Mdoa\17004249
Glossina morsitans
Tsetse fly
Gmor\GMOY007487
Glossina morsitans
Tsetse fly
Gmor\GMOY003159
Glossina morsitans
Tsetse fly
Gmor\GMOY003160
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00052
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00048
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00054
Mayetiola destructor
Hessian fly
Mdes\Mdes012145
Anopheles darlingi
American malaria mosquito
Adar\ADAC000126
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009517
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008236
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012711
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00UJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002383
Danaus plexippus
Monarch butterfly
Dple\DPOGS210252-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210251-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008031
Heliconius melpomene
Postman butterfly
Hmel\HMEL014654
Heliconius melpomene
Postman butterfly
Hmel\HMEL008030
Heliconius melpomene
Postman butterfly
Hmel\NIM-2
Apis florea
Little honeybee
Aflo\2147496819
Apis florea
Little honeybee
Aflo\2147496803
Apis florea
Little honeybee
Aflo\2354232276
Apis mellifera
Western honey bee
Amel\GB50508
Apis mellifera
Western honey bee
Amel\GB50509
Apis mellifera
Western honey bee
Amel\GB48687
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15752
Bombus terrestris
Buff-tailed bumblebee
Bter\15210802
Bombus terrestris
Buff-tailed bumblebee
Bter\15212780
Linepithema humile
Argentine ant
Lhum\LH26145
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c86
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008002
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008001
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04232
Tribolium castaneum
Red flour beetle
Tcas\TC031640
Tribolium castaneum
Red flour beetle
Tcas\NimB
Rhodnius prolixus
Kissing bug
Rpro\RPRC004307
Rhodnius prolixus
Kissing bug
Rpro\RPRC004336
Cimex lectularius
Bed bug
Clec\CLEC003712
Cimex lectularius
Bed bug
Clec\CLEC003710
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00565
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07456
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13417
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11982
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03M1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003283gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_004359gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006982gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fibcd1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027541gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fic
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egfia_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_000817gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fic3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001373gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_002719gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021409gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009605gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fic1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009606gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_012578gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-TncL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egf/Ccp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FReD
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023633gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fbgp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Scavr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Angptl1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_012412gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fibcd1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Angptl1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mfag4L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fic2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027213gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1727
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tnc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_004342gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tnr_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egf/Lnb/7Tm/Gpcr_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017720gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Notch2L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027542gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wap/Wap_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_010834gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wap/Ty/Egf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fibcd1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_024361gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fbgp_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006151gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fibcd1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tnxb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_36
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z77
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_004928gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fbg/Egf/Clect
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2964
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006981gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022729gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023222gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Angptl1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016984gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Vwc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006980gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1661
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019802
Ciona intestinalis
Vase tunicate
Cint\LOC100182094
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021405
Ciona intestinalis
Vase tunicate
Cint\LOC100179852
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000010151
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019153
Ciona intestinalis
Vase tunicate
Cint\LOC100184314
Ciona intestinalis
Vase tunicate
Cint\LOC100178407
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021992
Ciona intestinalis
Vase tunicate
Cint\LOC100176826
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001531
Ciona intestinalis
Vase tunicate
Cint\LOC100177187
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003482
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005497
Ciona intestinalis
Vase tunicate
Cint\LOC100183414
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023637
Ciona intestinalis
Vase tunicate
Cint\fibrn
Ciona intestinalis
Vase tunicate
Cint\LOC100178409
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012917
Ciona intestinalis
Vase tunicate
Cint\LOC100175128
Ciona intestinalis
Vase tunicate
Cint\LOC100178820
Ciona intestinalis
Vase tunicate
Cint\LOC100179147
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023980
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018658
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019770
Ciona intestinalis
Vase tunicate
Cint\LOC100184033
Ciona intestinalis
Vase tunicate
Cint\LOC100183808
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022245
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012948
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019392
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024396
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021970
Gallus gallus
Domestic chicken
Ggal\FGB
Gallus gallus
Domestic chicken
Ggal\ANGPTL5
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007113
Gallus gallus
Domestic chicken
Ggal\FIBCD1
Gallus gallus
Domestic chicken
Ggal\GGA.653
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026890
Gallus gallus
Domestic chicken
Ggal\ANGPTL1
Gallus gallus
Domestic chicken
Ggal\TNR
Gallus gallus
Domestic chicken
Ggal\FGG
Gallus gallus
Domestic chicken
Ggal\FGL1
Gallus gallus
Domestic chicken
Ggal\ANGPTL4
Gallus gallus
Domestic chicken
Ggal\angiopoietin-2
Gallus gallus
Domestic chicken
Ggal\ANGPTL7
Gallus gallus
Domestic chicken
Ggal\MFAP4
Gallus gallus
Domestic chicken
Ggal\TNN
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009151
Gallus gallus
Domestic chicken
Ggal\ANGPT1
Gallus gallus
Domestic chicken
Ggal\FGA
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006832
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027520
Gallus gallus
Domestic chicken
Ggal\FGL2
Gallus gallus
Domestic chicken
Ggal\ANGPTL2
Gallus gallus
Domestic chicken
Ggal\ANGPTL3
Gallus gallus
Domestic chicken
Ggal\LOC428073
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (24)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
NimC1
5 of 10
NimC2
5 of 10
NimB1
4 of 10
NimB2
4 of 10
NimB4
4 of 10
NimB5
3 of 10
CG1791
1 of 10
CG1889
1 of 10
CG5550
1 of 10
CG6788
1 of 10
CG8642
1 of 10
CG9500
1 of 10
CG10359
1 of 10
CG11674
1 of 10
CG15861
1 of 10
CG30280
1 of 10
CG30281
1 of 10
CG31832
1 of 10
drpr
1 of 10
NimA
1 of 10
NimB3
1 of 10
NimC3
1 of 10
NimC4
1 of 10
sca
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    eaterunspecified
    model of  bacterial infectious disease
    CEA
    (Christofi and Apidianakis, 2013)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-92
    Cytogenetic map
    97E2-97E2
    Sequence location
    3R:27,095,867..27,099,679 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    97E2-97E2
    Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    3-92
    (FlyBase, 2016)
    3-89.6
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (11)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (2)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Chung and Kocks, 2011)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: eater CG6124
        (Kocks et al., 2005)
        Additional comments
        Other Comments
        S2 cells treated with dsRNA directed against eater show decreased uptake of S.aureus by phagocytosis compared to control cells.
        (Stuart et al., 2007)
        Silencing of eater in S2 cells results in a strong decrease in phagocytosis of both Gram-positive and Gram-negative bacteria in these cells. The defect is in the recognition and binding of the pathogens.
        (Kocks et al., 2005)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 23 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Synonyms and Secondary IDs (6)
        Reported As
        Symbol Synonym
        C901-like
        (Hynes and Zhao, 2000)
        CG6124
        (Okuda et al., 2016, Palu and Thummel, 2016, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Douglas et al., 2011, Perkins et al., 2009.1.15, Carrera et al., 2008, Kurucz et al., 2007, Stuart et al., 2007, Kocks et al., 2005)
        CT19227
        (Hynes and Zhao, 2000)
        Dmel_CG6124
        (Radyuk et al., 2012)
        Eater
        (Vlisidou and Wood, 2015, Péan and Dionne, 2014, Wang et al., 2014, Bier and Guichard, 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Longworth et al., 2012, Douglas et al., 2011, Fernández-Ayala et al., 2010, Brennan et al., 2007)
        eater
        (Asri et al., 2019, Banerjee et al., 2019, Melcarne et al., 2019, Sinha et al., 2019, Abhyankar et al., 2018, Hao et al., 2018, Yu et al., 2018, Clandinin and Owens, 2016-, Bretscher et al., 2015, Honti et al., 2014, Christofi and Apidianakis, 2013, Kroeger et al., 2013, Hamilos et al., 2012, Kroeger et al., 2012, Paré et al., 2012, Akbar et al., 2011, Gonsalves et al., 2011, Igboin et al., 2011, Nehme et al., 2011, Ulvila et al., 2011, Ye and McGraw, 2011, Honti et al., 2010, Juneja and Lazzaro, 2010, Somogyi et al., 2010, Stofanko et al., 2010, Charroux and Royet, 2009, Hashimoto et al., 2009, Tokusumi et al., 2009, Carrera et al., 2008, Chamilos et al., 2008, Sackton et al., 2007, Ulvila et al., 2006, Erturk-Hasdemir and Silverman, 2005, Kocks et al., 2005)
        Name Synonyms
        CG6124
        Eater
        (Yu et al., 2018, Parsons and Foley, 2016, Arefin et al., 2014, Rocha et al., 2011, Defaye et al., 2009, Cho and Kocks, 2007, Kurucz et al., 2007, Kurucz et al., 2007)
        eater
        (Vanha-Aho et al., 2012, Charroux and Royet, 2009, Hashimoto et al., 2009, Tokusumi et al., 2009, Ye et al., 2009, Perrimon and Mathey-Prevot, 2007, Sorrentino et al., 2007, Stuart et al., 2007, Kocks et al., 2005, Kocks et al., 2005)
        Secondary FlyBase IDs
        • FBgn0082595
        • FBgn0039484
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (91)