FB2019_05, released Oct 15, 2019

Gene: Dmel\Vrp1

Open Close
General Information
Symbol
Dmel\Vrp1
Species
D. melanogaster
Name
Verprolin 1
Annotation Symbol
CG13503
Feature Type
protein_coding_gene
FlyBase ID
FBgn0243516
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. [Date last reviewed: 2019-03-21]
Other Summaries
Also Known As
sltr, D-WIP, solitary, wip, Verprolin
Key Links
Genomic Location
Cytogenetic map
58B8-58B9
Sequence location
2R:22,106,107..22,122,562 [-]
Recombination map
2-98
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
actin filament binding
Predictions / Assertions
actin filament binding
Summaries
Summary (Interactive Fly)
facilitator of myoblast fusion - homolog of the conserved Verprolin/WASp Interacting Protein family of WASp-binding proteins - recruits the actin-polymerization machinery to sites of myoblast attachment and fusion
Gene Model and Products
Number of Transcripts
12
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\Vrp1 or the JBrowse view of Dmel\Vrp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.51
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
(Chen, 2006)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vrp1-RA
FBtr0071793
NM_166508
3823
751
Vrp1-RB
FBtr0071791
NM_166509
3686
751
Vrp1-RC
FBtr0071795
NM_166510
3345
751
Vrp1-RD
FBtr0071794
NM_166511
3331
751
Vrp1-RE
FBtr0071796
NM_137796
3263
761
Vrp1-RF
FBtr0071792
NM_166507
3407
708
Vrp1-RG
FBtr0113104
NM_001103936
4017
852
Vrp1-RH
FBtr0302295
NM_001169775
3134
718
Vrp1-RI
FBtr0302296
NM_001169776
3410
809
Vrp1-RJ
FBtr0302297
NM_001169777
3888
809
Vrp1-RK
FBtr0302298
NM_001169778
3216
708
Vrp1-RL
FBtr0342980
NM_001299775
3281
767
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Vrp1-PA
FBpp0071706
76.4
751
11.89
NP_726160
AAF46800
Vrp1-PB
FBpp0071704
76.4
751
11.89
NP_726161
AAM68205
Vrp1-PC
FBpp0071708
76.4
751
11.89
NP_726162
AAM68206
Vrp1-PD
FBpp0071707
76.4
751
11.89
NP_726163
AAM68207
Vrp1-PE
FBpp0071709
77.6
761
11.99
NP_611640
AAM68208
Vrp1-PF
FBpp0071705
71.2
708
11.98
NP_726159
AAM68204
Vrp1-PG
FBpp0112017
86.3
852
11.96
NP_001097406
ABV53875
Vrp1-PH
FBpp0291501
72.5
718
12.08
NP_001163246
ACZ94518
Vrp1-PI
FBpp0291502
81.1
809
12.05
NP_001163247
ACZ94519
Vrp1-PJ
FBpp0291503
81.1
809
12.05
NP_001163248
ACZ94520
Vrp1-PK
FBpp0291504
71.2
708
11.98
NP_001163249
ACZ94521
Vrp1-PL
FBpp0309744
78.3
767
11.94
NP_001286704
AHN56499
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

751 aa isoforms: Vrp1-PA, Vrp1-PB, Vrp1-PC, Vrp1-PD
708 aa isoforms: Vrp1-PF, Vrp1-PK
809 aa isoforms: Vrp1-PI, Vrp1-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vrp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
actin filament binding
inferred from direct assay
(Kim et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
behavioral response to ethanol
inferred from mutant phenotype
(Kong et al., 2010)
myoblast fusion
inferred from mutant phenotype
(Berger et al., 2008, Kim et al., 2007, Massarwa et al., 2007, Estrada et al., 2006)
positive regulation of actin filament polymerization
inferred from direct assay
(Kim et al., 2007)
regulation of actin filament polymerization
inferred from mutant phenotype
(Rotkopf et al., 2011)
spermatid development
inferred from mutant phenotype
(Rotkopf et al., 2011)
visceral muscle development
inferred from mutant phenotype
(Eriksson et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
actin cortical patch assembly
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
actin cortical patch localization
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
actin filament-based movement
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Kim et al., 2007)
filopodium tip
inferred from direct assay
(Berger et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
actin cortical patch
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
actin filament
inferred from biological aspect of ancestor with PANTHER:PTN001506182
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 9 -- 10
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11
embryonic precursor cell of adult muscle
(Massarwa et al., 2007)
embryonic stage 11 -- 12
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
visceral mesoderm
(Eriksson et al., 2010)
embryonic stage 11 -- 14
embryonic somatic muscle

Comment: expressed in fusion-competent myoblasts at sites of fusion

(Kim et al., 2007)
embryonic visceral muscle
(Kim et al., 2007)
embryonic stage 12
fusion competent cell
(Massarwa et al., 2007)
embryonic stage 12 -- 14
somatic mesoderm
(Eriksson et al., 2010)
embryonic stage 12 -- 15
embryonic myoblast
(Massarwa et al., 2007)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
Additional Descriptive Data
Vrp1 is expressed in somatic and visceral muscle starting in embryonic stage 11 and persists in somatic muscle until the end of stage 14 when fusion is completed. It is observed in fusion-competent cells but not in founder cells. It is found within the cytoplasm, specifically at sites of fusion.
(Kim et al., 2007)
Vrp1 expressionis absent during early stages, and is first observed at stage 11 in mesodermal muscle precursors, resolving into myoblast-specific expression that peaks at stage 14, then diminishes and disappears by stage 16.
(Massarwa et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
muscle attachment site
(Eriksson et al., 2010)
embryonic/larval somatic muscle
(Eriksson et al., 2010)
embryonic stage 11 -- 14
embryonic somatic muscle

Comment: expressed in fusion-competent myoblasts at sites of fusion

(Kim et al., 2007)
embryonic visceral muscle
(Kim et al., 2007)
fusion competent cell
(Eriksson et al., 2010)
visceral mesoderm
(Eriksson et al., 2010)
embryonic stage 14
fusion competent cell
(Jin et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Vrp1 protein expression is specific to fusion competent cells, and is not expressed in muscle founder cells.
(Jin et al., 2011)
Vrp1 is strongly expressed in muscles. It is found in both embryonic visceral mesoderm and somatic muscle as well as muscle attachment sites. Expression in the visceral mesoderm is specific to fusion competent cells and it is not found in muscle founder cells.
(Eriksson et al., 2010)
Vrp1 is expressed in somatic and visceral muscle starting in embryonic stage 11 and persists in somatic muscle until the end of stage 14 when fusion is completed. It is observed in fusion-competent cells but not in founder cells. It is found within the cytoplasm, specifically at sites of fusion.
(Kim et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Kim et al., 2007)
filopodium tip
inferred from direct assay
(Berger et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Vrp1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vrp1
Transgenic constructs containing regulatory region of Vrp1
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
male sterile
male sterile, with Scer\GAL4A3.eya
male sterile, with Scer\GAL4Mef2.PR, Vrp1S1946/Vrp1D30
male sterile (with Vrp1D30), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
male sterile (with Vrp1S1946), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
chemical sensitive
hypoactive | conditional
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
actin cytoskeleton
actin filament, with Scer\GAL4Mef2.PR, Vrp1S1946/Vrp1D30
actin filament (with Vrp1D30)
actin filament (with Vrp1D30), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
actin filament (with Vrp1KO)
actin filament (with Vrp1S1946), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
actin filament & fusion competent cell
actin filament & muscle founder cell
dorsal acute muscle | embryonic stage
dorsal pharyngeal muscle
embryonic/larval somatic muscle, with Scer\GAL4twi.PB
embryonic myoblast
embryonic somatic muscle
exocytic vesicle & fusion competent cell
fusion competent cell
head cyst cell, with Scer\GAL4Mef2.PR, Vrp1S1946/Vrp1D30
head cyst cell (with Vrp1D30)
head cyst cell (with Vrp1D30), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
head cyst cell (with Vrp1KO)
head cyst cell (with Vrp1S1946), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
mesothoracic tergum, with Scer\GAL4pnr-MD237
muscle founder cell
myoblast, with Scer\GAL4twi.PB
myoblast | embryonic stage
plasma membrane | embryonic stage
seminal vesicle
seminal vesicle, with Scer\GAL4A3.eya
seminal vesicle, with Scer\GAL4Mef2.PR, Vrp1S1946/Vrp1D30
seminal vesicle (with Vrp1D30), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
seminal vesicle (with Vrp1S1946), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
spermatid cyst
spermatid cyst, with Scer\GAL4A3.eya
spermatid cyst, with Scer\GAL4Mef2.PR, Vrp1S1946/Vrp1D30
spermatid cyst (with Vrp1D30)
spermatid cyst (with Vrp1D30), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
spermatid cyst (with Vrp1KO)
spermatid cyst (with Vrp1S1946), with Scer\GAL4Mef2.PR, Vrp1UAS.cMa
visceral muscle fiber | embryonic stage
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\WIPF1
3 of 15
Yes
Yes
Hsap\WIPF2
2 of 15
No
Yes
Hsap\TIGD5
1 of 15
No
No
Hsap\WIPF3
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Wipf1
3 of 15
Yes
Yes
Mmus\Wipf2
2 of 15
No
Yes
Mmus\Wipf3
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Wipf2
2 of 13
Yes
Yes
Rnor\Wipf1
1 of 13
No
Yes
Rnor\Wipf3
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\wipf1
1 of 12
Yes
Yes
Xtro\wipf2
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (5)
Drer\wipf1b
3 of 15
Yes
Yes
Drer\sb:cb649
2 of 15
No
Yes
Drer\wipf2a
2 of 15
No
Yes
Drer\wipf2b
2 of 15
No
Yes
Drer\wipf1a
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\wip-1
3 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VRP1
3 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\vrp1
3 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909AK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Vrp1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003519
Drosophila simulans
Dsim\GD25144
Drosophila sechellia
Dsec\GM15662
Drosophila erecta
Dere\GG20718
Drosophila yakuba
Dyak\GE13649
Drosophila ananassae
Dana\GF11591
Drosophila pseudoobscura pseudoobscura
Dpse\GA25141
Drosophila persimilis
Dper\GL11837
Drosophila willistoni
Dwil\GK21915
Drosophila virilis
Dvir\GJ20490
Drosophila mojavensis
Dmoj\GI20754
Drosophila grimshawi
Dgri\GH21336
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150ECM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011226
Glossina morsitans
Tsetse fly
Gmor\GMOY003107
Glossina morsitans
Tsetse fly
Gmor\GMOY006562
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09891
Mayetiola destructor
Hessian fly
Mdes\Mdes005010
Mayetiola destructor
Hessian fly
Mdes\Mdes015190
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008154
Anopheles darlingi
American malaria mosquito
Adar\ADAC009994
Anopheles gambiae
Malaria mosquito
Agam\AGAP001886
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008382
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HPY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW023190
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
WASp
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WIPF1; WAS/WASL interacting protein family member 1
    3 of 15
    602357
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Vrp1 - Crk
      anti tag coimmunoprecipitation, anti tag western blot, pull down
      (Kim et al., 2007)
      Vrp1 - WASp
      anti tag coimmunoprecipitation, anti tag western blot, western blot, experimental knowledge based, pull down
      (Kaipa et al., 2013, Guruharsha et al., 2011, Jin et al., 2011, Kim et al., 2007)
      Vrp1 - blow
      anti tag coimmunoprecipitation, anti tag western blot, western blot
      (Jin et al., 2011)
      Vrp1 - dock
      anti tag coimmunoprecipitation, western blot, two hybrid
      (Kaipa et al., 2013)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Vrp1
      enhanceable
      dock
      (Kaipa et al., 2013)
      Vrp1
      enhanceable
      SCAR
      (Sens et al., 2010, Berger et al., 2008)
      Vrp1
      enhanceable
      WASp
      (Kaipa et al., 2013)
      Vrp1
      suppressible
      WASp
      (Massarwa et al., 2007)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      SCAR
      enhanceable
      Vrp1
      (Sens et al., 2010)
      sns
      enhanceable
      Vrp1
      (Kaipa et al., 2013)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-98
      Cytogenetic map
      58B8-58B9
      Sequence location
      2R:22,106,107..22,122,562 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      58B8-58B9
      Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      2-98
      (FlyBase, 2016)
      2-103.7
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (12)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (125)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Berger et al., 2008, Massarwa et al., 2007)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: D-WIP CG13503
        (Schejter, 2007.2.26)
        Source for identity of: sltr CG13503
        (Chen, 2007.2.26)
        Source for identity of: Vrp1 CG13503
        (Paunola et al., 2002)
        Source for database merge of
        Additional comments
        Other Comments
        EM analysis reveals abnormal accumulations of prefusion vesicles along the apposing membranes of adhering myoblasts in CG13503 mutant embryos, indicating a role of the actin cytoskeleton in targeting and fusion of these vesicles to proper sites on the plasma membrane.
        (Chen, 2007)
        Vrp1 is required for F-actin accumulation at sites of fusion in fusion-competent cells during muscle formation in the embryo.
        (Kim et al., 2007)
        CG13503, which is expressed specifically in myoblasts, associates with both the CG13503-Arp2/3 system, and with the myoblast fusion receptors kirre and sns, thereby recruiting the actin polymerization machinery to sites of myoblast attachment and fusion.
        (Schejter et al., 2007)
        Embryonic injection of dsRNA made from templates generated with primers directed against this gene results in a reduction in myoblast function, with an overall reduction and disorganisation of muscle fibers.
        (Estrada et al., 2006)
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        (Kiger et al., 2003)
        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape.
        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 72 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (29)
        Reported As
        Symbol Synonym
        CG13503
        (McEachern et al., 2014, Abmayr and Pavlath, 2012, Ni et al., 2011.7.19, Eriksson et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Chen, 2007.2.26, Kim et al., 2007, Massarwa et al., 2007, Schejter, 2007.2.26, Zhang et al., 2007, Estrada et al., 2006, Johansson et al., 2005)
        D-WIP
        (Mukherjee et al., 2011, Rotkopf et al., 2011, Bulchand et al., 2010, Gildor et al., 2009, Massarwa et al., 2007, Massarwa et al., 2007, Richardson et al., 2007, Schejter, 2007.2.26, Schejter et al., 2007)
        DWIP
        (Martin, 2016)
        DWip
        (Bothe and Baylies, 2016)
        Dm_Vrp1
        (Paunola et al., 2002)
        Sltr
        (Rodal et al., 2015, Abmayr and Pavlath, 2012)
        Vrp1
        (Gene Disruption Project members, 2018-, Sarov et al., 2016, Ashwal-Fluss et al., 2014, Popichenko et al., 2013, Abmayr and Pavlath, 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Eriksson et al., 2010, Berger et al., 2008, Paunola et al., 2002)
        WIP
        (Dubey et al., 2016, Reed et al., 2012, Zoller and Schulz, 2012, Jin et al., 2011, Wolfstetter et al., 2009)
        Wip
        (Abmayr and Pavlath, 2012)
        dWIP
        (Rodal et al., 2015, Sens et al., 2010, Sens and Chen, 2008)
        sltr
        (Kim et al., 2015, Duan et al., 2012, Jin et al., 2011, Bulchand et al., 2010, Sens et al., 2010, Berger et al., 2008, Chen, 2007, Chen, 2007.2.26, Kim et al., 2007, Chen, 2006)
        solas
        (Estrada et al., 2006)
        vrp
        (Álvarez-Fernández et al., 2015)
        vrp1
        (Dubois et al., 2016, Hamp et al., 2016, Kaipa et al., 2013, Bulchand et al., 2010, Berger et al., 2008)
        wip
        (Haralalka et al., 2014, Rudolf et al., 2014, Kaipa et al., 2013, Hornbruch-Freitag et al., 2011, Berger et al., 2008)
        Name Synonyms
        CG13503
        D-WASp-interacting protein
        (Gildor et al., 2009)
        Drosophila WIP
        (Chen, 2007)
        Solitary
        (Bulchand et al., 2010)
        Verprolin
        (Reed et al., 2012, Eriksson et al., 2010, Kong et al., 2010)
        Verprolin 1
        (McEachern et al., 2014, Bulchand et al., 2010, Lebo et al., 2009)
        Verprolin1
        (Wolfstetter et al., 2009)
        WASP-interacting protein
        (Hornbruch-Freitag et al., 2011)
        WASp Interacting Protein
        (Schejter, 2007.2.26, Schejter et al., 2007)
        WASp interacting protein
        (Bulchand et al., 2010)
        WASp-interacting protein
        (Dubey et al., 2016)
        solitary
        (Jin et al., 2011, Sens and Chen, 2008, Chen, 2007, Chen, 2007.2.26, Kim et al., 2007, Chen, 2006)
        veroprolin
        (Reed et al., 2012)
        verprolin
        (Estrada et al., 2006, Paunola et al., 2002)
        verprolin 1
        (Schäfer et al., 2008)
        Secondary FlyBase IDs
        • FBgn0034695
        • FBgn0086255
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (79)