• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Prosβ7

General Information
Symbol	Dmel\Prosβ7	Species	D. melanogaster
Name	Proteasome β7 subunit	Annotation symbol	CG12000
Feature type	protein_coding_gene	FlyBase ID	FBgn0250746
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82F11-82F11	Sequence location	3R:1,182,734..1,184,086 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome β7 subunit is referred to in FlyBase by the symbol Dmel\Prosβ7 (CG12000, FBgn0250746). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; mitotic spindle elongation; cell proliferation; cellular process; response to DNA damage stimulus; mitotic spindle organization; neurogenesis. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Proteasome B-type subunit; Proteasome endopeptidase complex, beta subunit; Proteasome, beta-type subunit, conserved site; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1630851_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Prosbeta7. Gene sequence location is 3R:1182734..1184086.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN28365 HFA12186
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82F11-82F11   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prosβ7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Used LD28886.3prime and LD28377.3prime for 3' extent.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prosβ7-RA FBtr0078805  NM_141272   1215   268 Prosβ7-RB FBtr0078806  NM_169049   1024   268
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prosβ7-PA   FBpp0078448   30.0   268   6.52     NP_649529   AAF52041 Prosβ7-PB   FBpp0078449   30.0   268   6.52     NP_730922   AAN13277
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, subunit alpha/beta (IPR001353) Proteasome B-type subunit (IPR023333) Proteasome, beta-type subunit, conserved site (IPR016050) Proteasome endopeptidase complex, beta subunit (IPR016295)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246673   AA264105   AA390444   AA438649   AA440550   AA441362   AA694942   AA695811   AA803159   AA803165   AA803403   AA820570   AA820758   AA941353   AA949542   AA950357   AA950586   AA990680   AE014297 AAF52041   AE014297 AAN13277   AI061877   AI064182   AI108406   AI113784   AI294552   AI296643   AI296954   AI386884   AI455509   AI456795   AI519648   AX094202   AY118936 AAM50796   BE976407   BF503083   BI172901   BI214601   BI228352   BI242497   BI354820   BI361325   BI367515   BI369281   BI371783   BI373931   BI375403   BI482822   BI564122   BI564638   BI585623   BI586279   BI586874   BI587349   BI613026   BI613038   BI613979   BI618663   BI625237   BI631027   BI631168   BI635157   BI639400   BP552549   CK131849   CK660116   CL528198   CO153461   CO155463   CO177261   CO194213   CO299129   CO304047   CO304057   CO316138   CO320680   CZ479810   CZ489687   CZ490111   CZ490112   EC058195   EC065415   EC067549   EC202210   EC204738   EC218473   EC227793   EC227976   EC236724   EC250508   EC263658   EC267492   ES693046   ES693110   EV588437   EV592117   EV596670   EV597668   GH739101   GH739699   GH739847   GH740275   GH743387   GH743529   GH744021   GH744777   GH744923   GH745145   GH745898   GH746838   GH761658   GH762753   GH764042   GH765577   GH766355   GH766821   GH767273   GH767558   GH767689   GH767912   GH768288   GH768802   GH769117   GH769405   GH769732
UniProtKB/Swiss-Prot	Q9VNA5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0250746    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0250746 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0250746 expression level Developmental Stage   Expression Level embryo 00-02hr    25876 embryo 02-04hr    35393 embryo 04-06hr    17785 embryo 06-08hr    10058 embryo 08-10hr    10581 embryo 10-12hr    10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2    12061 larva L3 12hr old    8703 larva L3 puffstage 1-2    11415 larva L3 puffstage 3-6    18533 larva L3 puffstage 7-9    22292 white prepupae new    23789 white prepupae 12hr    11014 white prepupae 24hr    11678 pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP    13100 adult male 01day    11236 adult male 05day    11731 adult male 30day    12423 adult female 01day    13911 adult female 05day    14797 adult female 30day    14814 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  (17785) embryo 06-08hr  (10058) embryo 08-10hr  (10581) embryo 10-12hr  (10206) embryo 12-14hr  (6660) embryo 14-16hr  (8532) embryo 16-18hr  (5837) embryo 18-20hr  (4318) embryo 20-22hr  (5282) embryo 22-24hr  (4606) larva L1  (5411) larva L2  (12061) larva L3 12hr old  (8703) larva L3 puffstage 1-2  (11415) larva L3 puffstage 3-6  (18533) larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  (11014) white prepupae 24hr  (11678) pupae 2d postWPP  (8258) pupae 3d postWPP  (7210) pupae 4d postWPP  (13100) adult male 01day  (11236) adult male 05day  (11731) adult male 30day  (12423) adult female 01day  (13911) adult female 05day  (14797) adult female 30day  (14814) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  (17785) embryo 06-08hr  (10058) embryo 08-10hr  (10581) embryo 10-12hr  (10206) embryo 12-14hr  (6660) embryo 14-16hr  (8532) embryo 16-18hr  (5837) embryo 18-20hr  (4318) embryo 20-22hr  (5282) embryo 22-24hr  (4606) larva L1  (5411) larva L2  (12061) larva L3 12hr old  (8703) larva L3 puffstage 1-2  (11415) larva L3 puffstage 3-6  (18533) larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  (11014) white prepupae 24hr  (11678) pupae 2d postWPP  (8258) pupae 3d postWPP  (7210) pupae 4d postWPP  (13100) adult male 01day  (11236) adult male 05day  (11731) adult male 30day  (12423) adult female 01day  (13911) adult female 05day  (14797) adult female 30day  (14814) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  (17785) embryo 06-08hr  10058 embryo 08-10hr  10581 embryo 10-12hr  10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2  (12061) larva L3 12hr old    8703 larva L3 puffstage 1-2  (11415) larva L3 puffstage 3-6  (18533) larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  (11014) white prepupae 24hr  (11678) pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP  (13100) adult male 01day  (11236) adult male 05day  (11731) adult male 30day  (12423) adult female 01day  (13911) adult female 05day  (14797) adult female 30day  (14814) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25876 embryo 02-04hr    35393 embryo 04-06hr    17785 embryo 06-08hr    10058 embryo 08-10hr    10581 embryo 10-12hr    10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2    12061 larva L3 12hr old    8703 larva L3 puffstage 1-2    11415 larva L3 puffstage 3-6    18533 larva L3 puffstage 7-9    22292 white prepupae new    23789 white prepupae 12hr    11014 white prepupae 24hr    11678 pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP    13100 adult male 01day    11236 adult male 05day    11731 adult male 30day    12423 adult female 01day    13911 adult female 05day    14797 adult female 30day    14814 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0250746 expression level Developmental Stage   Expression Level embryo 00-02hr    25876 embryo 02-04hr    35393 embryo 04-06hr    17785 embryo 06-08hr    10058 embryo 08-10hr    10581 embryo 10-12hr    10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2    12061 larva L3 12hr old    8703 larva L3 puffstage 1-2    11415 larva L3 puffstage 3-6    18533 larva L3 puffstage 7-9    22292 white prepupae new    23789 white prepupae 12hr    11014 white prepupae 24hr    11678 pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP    13100 adult male 01day    11236 adult male 05day    11731 adult male 30day    12423 adult female 01day    13911 adult female 05day    14797 adult female 30day    14814 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  (17785) embryo 06-08hr  (10058) embryo 08-10hr  (10581) embryo 10-12hr  (10206) embryo 12-14hr  (6660) embryo 14-16hr  (8532) embryo 16-18hr  (5837) embryo 18-20hr  (4318) embryo 20-22hr  (5282) embryo 22-24hr  (4606) larva L1  (5411) larva L2  (12061) larva L3 12hr old  (8703) larva L3 puffstage 1-2  (11415) larva L3 puffstage 3-6  (18533) larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  (11014) white prepupae 24hr  (11678) pupae 2d postWPP  (8258) pupae 3d postWPP  (7210) pupae 4d postWPP  (13100) adult male 01day  (11236) adult male 05day  (11731) adult male 30day  (12423) adult female 01day  (13911) adult female 05day  (14797) adult female 30day  (14814) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  (17785) embryo 06-08hr  (10058) embryo 08-10hr  (10581) embryo 10-12hr  (10206) embryo 12-14hr  (6660) embryo 14-16hr  (8532) embryo 16-18hr  (5837) embryo 18-20hr  (4318) embryo 20-22hr  (5282) embryo 22-24hr  (4606) larva L1  (5411) larva L2  (12061) larva L3 12hr old  (8703) larva L3 puffstage 1-2  (11415) larva L3 puffstage 3-6  (18533) larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  (11014) white prepupae 24hr  (11678) pupae 2d postWPP  (8258) pupae 3d postWPP  (7210) pupae 4d postWPP  (13100) adult male 01day  (11236) adult male 05day  (11731) adult male 30day  (12423) adult female 01day  (13911) adult female 05day  (14797) adult female 30day  (14814) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (25876) embryo 02-04hr  (35393) embryo 04-06hr  17785 embryo 06-08hr  10058 embryo 08-10hr  10581 embryo 10-12hr  10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2  12061 larva L3 12hr old    8703 larva L3 puffstage 1-2  11415 larva L3 puffstage 3-6  18533 larva L3 puffstage 7-9  (22292) white prepupae new  (23789) white prepupae 12hr  11014 white prepupae 24hr  11678 pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP  13100 adult male 01day  11236 adult male 05day  11731 adult male 30day  12423 adult female 01day  13911 adult female 05day  14797 adult female 30day  14814 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25876 embryo 02-04hr    35393 embryo 04-06hr    17785 embryo 06-08hr    10058 embryo 08-10hr    10581 embryo 10-12hr    10206 embryo 12-14hr    6660 embryo 14-16hr    8532 embryo 16-18hr    5837 embryo 18-20hr    4318 embryo 20-22hr    5282 embryo 22-24hr    4606 larva L1    5411 larva L2    12061 larva L3 12hr old    8703 larva L3 puffstage 1-2    11415 larva L3 puffstage 3-6    18533 larva L3 puffstage 7-9    22292 white prepupae new    23789 white prepupae 12hr    11014 white prepupae 24hr    11678 pupae 2d postWPP    8258 pupae 3d postWPP    7210 pupae 4d postWPP    13100 adult male 01day    11236 adult male 05day    11731 adult male 30day    12423 adult female 01day    13911 adult female 05day    14797 adult female 30day    14814 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0250746    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0250746 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0250746 expression level Tissue   Expression Level Larval Central Nervous System    1054.9 Larval Midgut    1491.2 Larval Hindgut    1296.2 Larval Malpighian Tubules    2464 Larval Fat Body    1363.8 Larval Salivary Gland    1528.5 Larval Trachea    1380.175 Larval Carcass    2264.85 Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body    2352.2 Adult Salivary Gland    570.4 Adult Heart    3774.65 Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary    1136.9 Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass    1950.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1054.9) Larval Midgut  (1491.2) Larval Hindgut  (1296.2) Larval Malpighian Tubules  (2464) Larval Fat Body  (1363.8) Larval Salivary Gland  (1528.5) Larval Trachea  (1380.175) Larval Carcass  (2264.85) Adult Head  (663.7) Adult Eye  (851.6) Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop  (978.9) Adult Midgut  (988.6) Adult Hindgut  (744.4) Adult Malpighian Tubules  (905.4) Adult Fat Body  (2352.2) Adult Salivary Gland  (570.4) Adult Heart  (3774.65) Adult VirginFemale Spermatheca  (844.6) Adult InseminatedFemale Spermatheca  (797.2) Adult Ovary  (1136.9) Adult Testis  (977.6) Adult Male Accessory Gland  (923.2) Adult Carcass  (1950.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1054.9 Larval Midgut  (1491.2) Larval Hindgut  (1296.2) Larval Malpighian Tubules  (2464) Larval Fat Body  (1363.8) Larval Salivary Gland  (1528.5) Larval Trachea  (1380.175) Larval Carcass  (2264.85) Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body  (2352.2) Adult Salivary Gland    570.4 Adult Heart  (3774.65) Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary  (1136.9) Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass  (1950.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1054.9 Larval Midgut    1491.2 Larval Hindgut    1296.2 Larval Malpighian Tubules    2464 Larval Fat Body    1363.8 Larval Salivary Gland    1528.5 Larval Trachea    1380.175 Larval Carcass    2264.85 Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body    2352.2 Adult Salivary Gland    570.4 Adult Heart    3774.65 Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary    1136.9 Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass    1950.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0250746 expression level Tissue   Expression Level Larval Central Nervous System    1054.9 Larval Midgut    1491.2 Larval Hindgut    1296.2 Larval Malpighian Tubules    2464 Larval Fat Body    1363.8 Larval Salivary Gland    1528.5 Larval Trachea    1380.175 Larval Carcass    2264.85 Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body    2352.2 Adult Salivary Gland    570.4 Adult Heart    3774.65 Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary    1136.9 Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass    1950.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1054.9) Larval Midgut  (1491.2) Larval Hindgut  (1296.2) Larval Malpighian Tubules  (2464) Larval Fat Body  (1363.8) Larval Salivary Gland  (1528.5) Larval Trachea  (1380.175) Larval Carcass  (2264.85) Adult Head  663.7 Adult Eye  (851.6) Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop  (978.9) Adult Midgut  (988.6) Adult Hindgut  744.4 Adult Malpighian Tubules  (905.4) Adult Fat Body  (2352.2) Adult Salivary Gland  570.4 Adult Heart  (3774.65) Adult VirginFemale Spermatheca  (844.6) Adult InseminatedFemale Spermatheca  797.2 Adult Ovary  (1136.9) Adult Testis  (977.6) Adult Male Accessory Gland  (923.2) Adult Carcass  (1950.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1054.9 Larval Midgut  1491.2 Larval Hindgut  1296.2 Larval Malpighian Tubules  (2464) Larval Fat Body  1363.8 Larval Salivary Gland  1528.5 Larval Trachea  1380.175 Larval Carcass  (2264.85) Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body  (2352.2) Adult Salivary Gland    570.4 Adult Heart  (3774.65) Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary  1136.9 Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass  (1950.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1054.9 Larval Midgut    1491.2 Larval Hindgut    1296.2 Larval Malpighian Tubules    2464 Larval Fat Body    1363.8 Larval Salivary Gland    1528.5 Larval Trachea    1380.175 Larval Carcass    2264.85 Adult Head    663.7 Adult Eye    851.6 Adult Brain    344 Adult Thoracic-Abdominal Ganglion    450.8 Adult Crop    978.9 Adult Midgut    988.6 Adult Hindgut    744.4 Adult Malpighian Tubules    905.4 Adult Fat Body    2352.2 Adult Salivary Gland    570.4 Adult Heart    3774.65 Adult VirginFemale Spermatheca    844.6 Adult InseminatedFemale Spermatheca    797.2 Adult Ovary    1136.9 Adult Testis    977.6 Adult Male Accessory Gland    923.2 Adult Carcass    1950.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    663.7   NA  Eye    851.6   NA  Brain    344   1054.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    450.8   NA  Crop    978.9   1491.2  Midgut    988.6   1296.2  Hindgut    744.4   2464  Malpighian Tubules    905.4   1363.8  Fat Body    2352.2   1528.5  Salivary Gland    570.4   NA  Heart    3774.65   1380.175  Trachea    NA   NA  VirginFemale Spermatheca    844.6   NA  InseminatedFemale Spermatheca    797.2   NA  Ovary    1136.9   NA  Testis    977.6   NA  Male Accessory Gland    923.2   2264.85  Carcass    1950.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12000-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Prosβ7GD7457 lethal | pupal stage, with Scer\GAL4pnr-MD237 Prosβ7GD7457 viable Prosβ7EY10024 Sterility Allele fertile Prosβ7EY10024 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Prosβ7GD7457 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Prosβ7GD7457 ganglion mother cell | larval stage, with Scer\GAL41407 Prosβ7GD7457
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Prosβ7 Class Mutagen Stocks Known lesion Prosβ7e02000 piggyBac transposase 1 -- Prosβ7EY10024 P-element activity 1 -- Prosβ7f07292 piggyBac transposase 1 -- Prosβ75-HA-2642 0 -- Prosβ7f06946 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prosβ7 Class Mutagen Stocks Known lesion Prosβ7GD7457 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Prosβ7KK108365 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Prosβ7EY10024 NA miscellaneous insertions P{RS5}Prosβ75-HA-2642 NA PBac{RB}Prosβ7e02000 NA PBac{WH}Prosβ7f06946 NA PBac{WH}Prosβ7f07292 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Goshima et al., 2007) cellular process inferred from mutant phenotype (Boutros et al., 2004) centrosome organization inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
endopeptidase activity inferred from sequence or structural similarity with UniProtKB:P28024 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2001.10.16) threonine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR016295, InterPro:IPR023333 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis non-traceable author statement (Swiss-Prot Project Members, 2001.10.16) proteolysis involved in cellular protein catabolic process inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR016050 (FlyBase Curators et al., 2004-) ubiquitin-dependent protein catabolic process non-traceable author statement (Swiss-Prot Project Members, 2001.10.16)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2001.10.16) nucleus non-traceable author statement (Swiss-Prot Project Members, 2001.10.16) proteasome core complex inferred from sequence or structural similarity with UniProtKB:P28024 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2001.10.16)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prosβ7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65850 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250746 DroID - A comprehensive database of gene and protein interactions. • FBgn0250746 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40639
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20703 Dere\GG11060 Dgri\GH22652 Dmoj\GI10207 Dper\GL22187 Dpse\GA11323 Dsec\GM10644 Dsim\GD19625 Dvir\GJ10047 Dwil\GK14279 Dyak\GE25292
Curated drosophilid orthologs	Dpse\GA11323
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007049-PA Aedes aegypti (mosquito) AGAP011444-PA Anopheles gambiae (mosquito) AGAP012608-PA Anopheles gambiae (mosquito) XP_394993.1 Apis mellifera (honey bee) XP_001952328.1 Acyrthosiphon pisum (pea aphid) At1g56450.1 Arabidopsis thaliana (wall cress) 16747 Batrachochytrium dendrobatidis (chytrid fungus) 286692 Branchiostoma floridae (lancelet) BGIBMGA009684-PA Bombyx mori (silk worm) ENSBTAP00000028364 Bos taurus (bovine) CAL0000170 Candida albicans (a form of yeast) CN01961 Caenorhabditis brenneri (small nematode) CN22010 Caenorhabditis brenneri (small nematode) CBP17497 Caenorhabditis briggsae (nematode) CE20761 Caenorhabditis elegans (worm) ENSCAFP00000018692 Canis familiaris (dog) CAGL0A04719g Candida glabrata (haploid yeast) Chro.50050 Cryptosporidium hominis (obligate parasite) ENSCINP00000004728 Ciona intestinalis (sea squirt) JA01014 Caenorhabditis japonica (nematode) CMD060C Cyanidioschyzon merolae (red alga) cn11053 Cryptococcus neoformans (yeast-like fungus) cgd5_3220 Cryptosporidium parvum (protozoan parasite) CPIJ002907 Culex pipens (mosquito) ENSCPOP00000013710 Cavia porcellus (guinea pig) 137981 Chlamidomonas reinhardtii (green alga) RP06270 Caenorhabditis remanei (nematode) 178772 Capitella spl (polychaete worm) DDB0232934 Dictyostelium discoideum (amoeba) DDB0266501 Dictyostelium discoideum (amoeba) DEHA2F14322g Debaryomyces Hansenii (yeast) 99667 Daphnia pulex (daphnia) ENSDARP00000071396 Danio rerio (zebra fish) ENSECAP00000005144 Equus caballus (horse) XP_652586 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013097 Gymnopilus aculeatus (mushroom) ENSGALP00000028488 Gallus gallus (chicken) GL50803_1995 Giardia lamblia (flagellated protozoan) 65558 Hypsipyla robusta (cedar shoot borer) ENSP00000290541 Homo sapiens (human) KLLA0D11506g Kluyveromyces lactis (yeast) 230810 Lottia gigantea (owl limpet) LmjF34.4340 Leishmania major (virus) LmjF34.4370 Leishmania major (virus) LmjF34.4400 Leishmania major (virus) LmjF34.4430 Leishmania major (virus) LmjF34.4460 Leishmania major (virus) LmjF34.4490 Leishmania major (virus) LmjF34.4520 Leishmania major (virus) 11719 Monocosta brevicollis (choanoflagellate) ENSMODP00000023545 Monodelphis domestica (gray opossum) ENSMMUP00000027532 Macaca mulatta (rhesus monkey) ENSMUSP00000005923 Mus musculus (house mouse) 167347 Nematostella vectensis (starlet anemone) XP_001601321.1 Nasonia vitripennis (wasp) ENSOANP00000002682 Ornithorynchus anatinus (platypus) ENSORLP00000001577 Oryzias latipes (japanese killifish) LOC_Os09g33986.1 Oryza sativa (asian rice) 23737 Ostreococcus tauri (green alga) MAL8P1.142 Plasmodium falciparum (protozoal parasite) PHUM001769-PA Pediculus humanus (human body louse) 109423 Physcomitrella patens (moss) ENSPPYP00000001012 Pongo pygmaeus (orangutan) 72254 Phytophthora ramorum (sudden oak death pathogen) 158871 Phytophthora sojae (root rot pathogen) 561786 Populus trichocarpa (black cottonwood) ENSPTRP00000002194 Pan troglodytes (chimpanzee) PVX_093555 Plasmodium vivax (protozoal parasite) ENSRNOP00000028484 Rattus norvegicus (norway rat) 4748559 Sorghum bicolor (sorghum) YFR050C Saccharomyces cerevisiae (budding yeast) Smp_056500 Schistosoma mansoni (trematode parasite) SPBC577.10 Schizosaccharomyces pombe (fission yeast) XP_001177443.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001183744.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001188161.1 Strongylocentrotus purpuratus (purple sea urchin) 23895 Trichoplax adhaerens (metazoa) TA04595 Theileria annulata (apicomplexan parasite) XP_974991.1 Tribolium castaneum (red flour beetle) Tc00.1047053510689.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008070 Tetraodon nigroviridis (green spotted pufferfish) TP03_0446 Theileria parva (parasitic protozoan) 24318 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000321 Takifugu rubripes (pufferfish Takifugu) 3729.m00069 Tetrahymena thermophila (ciliate protozoa) 90013.m00077 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0E32505g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11044 LH14022 ISCW004008 FBgn0242372 FBgn0221840 FBgn0216285 FBgn0197337 FBgn0191116 FBgn0165590 JGI_V11_99667 FBgn0071377 FBgn0159779 FBgn0133716 FBgn0132973 FBgn0130110 FBgn0124039 FBgn0103362 FBgn0100319 FBgn0097709 CPIJ002907 BGIBMGA009684 ACYPI006743 GB19777 AGAP012608 AGAP011444 AAEL007049 PB23185 PHUM066580 GLEAN_08617
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	16962 y1 w67c23; P{EPgy2}Prosβ7EY10024
Harvard	- PBac{RB}Prosβ7e02000 - PBac{WH}Prosβ7f07292
VDRC	v101990 P{KK108365}VIE-260B v16382 w1118; P{GD7457}v16382 v16381 w1118; P{GD7457}v16381/CyO
Genomic Clones ( 1 )
	BACR42H10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 114 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24633
Other clones	DPiM_LD24633
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT18989 GH03012 GH04464 GH07232 GH10240 GH17251 GM01826 GM04527 GM10324 GM10332 GM10780 GM28418 LD05586 LD07750 LD08740 LD12967 LD15365 LD16267 LD24366 LD25457 LD28377 LD28886 LD30443 LD34493 LD36926 LD39309 LP07954 LP10613 LP11083 LP12875 LP18390 RE15595 RE20559 RE25879 RE39851 RE45489 RE53293 RE55411 RE58765 RE61393 RE63193 RE65586 RH25244 RH26165 RH26986 RH28005 RH35834 RH42087 RH42105 RH43252 RH49543 RH60429 RH60588 RH61971 RH65536 SD16411 SD21969
Other clones	101326 101366 109274 178139 181216 190805 193662 193910 522430 524879 bs50c06 CK01.65A.H5 Dmel_neb_009868_0705_0468 Dmel_neb_011045_0883_2805 Dmel_neb_012533_0111_2212 Dmel_neb_015012_0947_2162 EC37623 EK053031 EK174605 EK243523 EK243538 EK263744 EK287046 EN02020 EN06110 FGM219D06 RC0-DE0001-140700-017-B05 RC0-DE0001-140700-026-B01 RP001005423 RP001007409 RP001008049 RP001008164 RP001012362 RP001014092 RP001015269 RP001018923 RP001021169 RP001022515 RP001026359 RP001026600 RP001029250 RP001030328 RP001030695 RP001034865 RP001035590 RP001039362 RP001043057 RP001043917 RP001047006 RP001047223 RP001047631 RP001049754 RP001050614 RP001051384 RP001052432
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0250746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40639
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Prosβ4 CG12000 (Goshima et al., 2007)
Source for database merge of	Source for merge of: CG12000 anon-WO0118547.326 (FlyBase, 1996-)
Additional comments	Source for merge of CG12000 anon-WO0118547.326 was sequence comparison (date:051113). (FlyBase, 1996-) FlyBase curator comment: the symbol "Prosβ4" has been used to describe two different genes in the literature; it is used to refer to the gene corresponding to the CG17331 annotation in FBrf0152082, while it is used refer to the gene corresponding to the CG12000 annotation in FBrf0200397 and FBrf0201458. To try and minimise confusion, "Prosβ4" is not used as the valid symbol for either gene in FlyBase, but the "Prosβ4" synonym present under both genes. (FlyBase, 1992-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of short, monastral spindles and severe proliferation defects when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cells does not affect the number of prophase centrosomes, but monastral bipolar spindles are formed during mitosis, suggesting that the centrosomes are fused. (Goshima et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Area matching Drosophila EST AA441362. This EST has sequence similarity to mammalian proteasome subunit HsN3. Probable intron in gene represented by EST AA441362. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141272 NM_169049 RefSeq (Proteins) • NP_649529 NP_730922 DDBJ / EMBL / GenBank • AA441362 AA820758 AAF52041 AAM50796 AAN13277 AI455509 AX094202 AY118936 CL528198 CZ479810 CZ489687 CZ490111 CZ490112 Entrez Gene - A searchable database of RefSeq genes. • 40639 UniProtKB/Swiss-Prot • Q9VNA5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, subunit alpha/beta (IPR001353) Proteasome B-type subunit (IPR023333) Proteasome, beta-type subunit, conserved site (IPR016050) Proteasome endopeptidase complex, beta subunit (IPR016295)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65850 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250746 DroID - A comprehensive database of gene and protein interactions. • FBgn0250746 DRSC - Results from RNAi screens. • FBgn0250746 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12000-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0250746 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 99062 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40639 InParanoid A subset of ortholog calls from InParanoid. • AAEL007049-PA Aedes aegypti (mosquito) AGAP011444-PA Anopheles gambiae (mosquito) AGAP012608-PA Anopheles gambiae (mosquito) XP_394993.1 Apis mellifera (honey bee) XP_001952328.1 Acyrthosiphon pisum (pea aphid) At1g56450.1 Arabidopsis thaliana (wall cress) 16747 Batrachochytrium dendrobatidis (chytrid fungus) 286692 Branchiostoma floridae (lancelet) BGIBMGA009684-PA Bombyx mori (silk worm) ENSBTAP00000028364 Bos taurus (bovine) CAL0000170 Candida albicans (a form of yeast) CN01961 Caenorhabditis brenneri (small nematode) CN22010 Caenorhabditis brenneri (small nematode) CBP17497 Caenorhabditis briggsae (nematode) CE20761 Caenorhabditis elegans (worm) ENSCAFP00000018692 Canis familiaris (dog) CAGL0A04719g Candida glabrata (haploid yeast) Chro.50050 Cryptosporidium hominis (obligate parasite) ENSCINP00000004728 Ciona intestinalis (sea squirt) JA01014 Caenorhabditis japonica (nematode) CMD060C Cyanidioschyzon merolae (red alga) cn11053 Cryptococcus neoformans (yeast-like fungus) cgd5_3220 Cryptosporidium parvum (protozoan parasite) CPIJ002907 Culex pipens (mosquito) ENSCPOP00000013710 Cavia porcellus (guinea pig) 137981 Chlamidomonas reinhardtii (green alga) RP06270 Caenorhabditis remanei (nematode) 178772 Capitella spl (polychaete worm) DDB0232934 Dictyostelium discoideum (amoeba) DDB0266501 Dictyostelium discoideum (amoeba) DEHA2F14322g Debaryomyces Hansenii (yeast) 99667 Daphnia pulex (daphnia) ENSDARP00000071396 Danio rerio (zebra fish) ENSECAP00000005144 Equus caballus (horse) XP_652586 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013097 Gymnopilus aculeatus (mushroom) ENSGALP00000028488 Gallus gallus (chicken) GL50803_1995 Giardia lamblia (flagellated protozoan) 65558 Hypsipyla robusta (cedar shoot borer) ENSP00000290541 Homo sapiens (human) KLLA0D11506g Kluyveromyces lactis (yeast) 230810 Lottia gigantea (owl limpet) LmjF34.4340 Leishmania major (virus) LmjF34.4370 Leishmania major (virus) LmjF34.4400 Leishmania major (virus) LmjF34.4430 Leishmania major (virus) LmjF34.4460 Leishmania major (virus) LmjF34.4490 Leishmania major (virus) LmjF34.4520 Leishmania major (virus) 11719 Monocosta brevicollis (choanoflagellate) ENSMODP00000023545 Monodelphis domestica (gray opossum) ENSMMUP00000027532 Macaca mulatta (rhesus monkey) ENSMUSP00000005923 Mus musculus (house mouse) 167347 Nematostella vectensis (starlet anemone) XP_001601321.1 Nasonia vitripennis (wasp) ENSOANP00000002682 Ornithorynchus anatinus (platypus) ENSORLP00000001577 Oryzias latipes (japanese killifish) LOC_Os09g33986.1 Oryza sativa (asian rice) 23737 Ostreococcus tauri (green alga) MAL8P1.142 Plasmodium falciparum (protozoal parasite) PHUM001769-PA Pediculus humanus (human body louse) 109423 Physcomitrella patens (moss) ENSPPYP00000001012 Pongo pygmaeus (orangutan) 72254 Phytophthora ramorum (sudden oak death pathogen) 158871 Phytophthora sojae (root rot pathogen) 561786 Populus trichocarpa (black cottonwood) ENSPTRP00000002194 Pan troglodytes (chimpanzee) PVX_093555 Plasmodium vivax (protozoal parasite) ENSRNOP00000028484 Rattus norvegicus (norway rat) 4748559 Sorghum bicolor (sorghum) YFR050C Saccharomyces cerevisiae (budding yeast) Smp_056500 Schistosoma mansoni (trematode parasite) SPBC577.10 Schizosaccharomyces pombe (fission yeast) XP_001177443.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001183744.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001188161.1 Strongylocentrotus purpuratus (purple sea urchin) 23895 Trichoplax adhaerens (metazoa) TA04595 Theileria annulata (apicomplexan parasite) XP_974991.1 Tribolium castaneum (red flour beetle) Tc00.1047053510689.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008070 Tetraodon nigroviridis (green spotted pufferfish) TP03_0446 Theileria parva (parasitic protozoan) 24318 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000321 Takifugu rubripes (pufferfish Takifugu) 3729.m00069 Tetrahymena thermophila (ciliate protozoa) 90013.m00077 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0E32505g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40639 modMine - Data generated by the modENCODE project. • FBgn0250746 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11044 LH14022 ISCW004008 FBgn0242372 FBgn0221840 FBgn0216285 FBgn0197337 FBgn0191116 FBgn0165590 JGI_V11_99667 FBgn0071377 FBgn0159779 FBgn0133716 FBgn0132973 FBgn0130110 FBgn0124039 FBgn0103362 FBgn0100319 FBgn0097709 CPIJ002907 BGIBMGA009684 ACYPI006743 GB19777 AGAP012608 AGAP011444 AAEL007049 PB23185 PHUM066580 GLEAN_08617
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	12000 (Ravi et al., 2009) 154275_at (Kristensen et al., 2005) anon-WO0118547.326   beta-4 (Goshima et al., 2007) CG12000 (Goshima et al., 2007, Goshima et al., 2007, Barbash and Lorigan, 2007, Zhou et al., 2008, Keleman et al., 2009.8.5, Ma et al., 2002, Bandyopadhyay et al., 2006, Buffin and Gho, 2010) GC12000 (Sumegi et al., 2003) Prosβ4 (Goshima et al., 2007, ) Prosβ7 (Ma et al., 2002)
Name Synonym	CG12000   Prosβ4   Proteasome β7 subunit   β-type 4 subunit (Adrain et al., 2004)
Secondary FlyBase IDs
	FBgn0037314 FBgn0062092 FBgn0243587
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 3 ) FlyBase analysis  ( 3 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Show all research papers ...