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Gene Dmel\exba

General Information
Symbol	Dmel\exba	Species	D. melanogaster
Name	extra bases	Annotation symbol	CG2922
Feature type	protein_coding_gene	FlyBase ID	FBgn0250753
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	eIF-5C, kra, elF-5C, l(3)03022
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83B4-83B4	Sequence location	3R:1,421,086..1,426,858 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene extra bases is referred to in FlyBase by the symbol Dmel\exba (CG2922, FBgn0250753). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; ribosome binding; translation initiation factor binding. There is experimental evidence that it is involved in the biological process: neuron fate commitment; oogenesis; long-term memory; behavioral response to ethanol; negative regulation of translation; axon midline choice point recognition. 41 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Armadillo-type fold; MIF4-like, type 1/2/3; W2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Gene sequence location is 3R:1421086..1426858.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms behavioral response to ethanol
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B4-83B4   Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83B4-83B4     (Wan, 2000.11.30) 83B4-83B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 83B1-83B5   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\exba for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) exba-RA FBtr0078744  NM_169074   2123   422 exba-RB FBtr0078749  NM_169075   1847   422 exba-RC FBtr0078746  NM_169076   1906   422 exba-RD FBtr0078748  NM_169077   2026   422 exba-RE FBtr0078750  NM_169078   1701   422 exba-RF FBtr0078747  NM_169079   1776   422 exba-RG FBtr0078745  NM_079514   1614   422
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein exba-PA   FBpp0078393   49.2   422   5.46     NP_730958   AAF51996 exba-PB   FBpp0078398   49.2   422   5.46     NP_730959   AAG22214 exba-PC   FBpp0078395   49.2   422   5.46     NP_730960   AAF51995 exba-PD   FBpp0078397   49.2   422   5.46     NP_730961   AAN13246 exba-PE   FBpp0078399   49.2   422   5.46     NP_730962   AAN13247 exba-PF   FBpp0078396   49.2   422   5.46     NP_730963   AAN13248 exba-PG   FBpp0078394   49.2   422   5.46     NP_524238   AAN13249
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • W2 domain (IPR003307) Armadillo-type fold (IPR016024) MIF4-like, type 1/2/3 (IPR016021)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201655   AA202725   AA202727   AA246238   AA263324   AA264112   AA264126   AA264219   AA264221   AA264579   AA264776   AA264960   AA390494   AA391055   AA391370   AA391443   AA392571   AA438336   AA438398   AA439066   AA439451   AA439703   AA440043   AA440402   AA440491   AA440858   AA441238   AA536418   AA539999   AA540051   AA540338   AA540357   AA540420   AA540617   AA540949   AA541131   AA541155   AA567833   AA694720   AA695530   AA695982   AA696942   AA697007   AA697033   AA697107   AA735439   AA735842   AA801897   AA801948   AA803397   AA803715   AA817450   AA820068   AA820429   AA820443   AA820662   AA820742   AA820751   AA820922   AA941275   AA941397   AA941572   AA941839   AA941915   AA942341   AA942561   AA948809   AA949459   AA949685   AA949896   AA949921   AA949999   AA950015   AA950029   AA950337   AA951533   AA951570   AA951921   AA952009   AA952137   AA978852   AA979218   AA979292   AA979643   AA990743   AA990798   AA990845   AE014297 AAF51995   AE014297 AAF51996   AE014297 AAG22214   AE014297 AAN13246   AE014297 AAN13247   AE014297 AAN13248   AE014297 AAN13249   AF325529 AAK01218   AI062112   AI062538   AI062605   AI063237   AI064143   AI064649   AI106759   AI106877   AI106880   AI107374   AI107435   AI107759   AI108312   AI109261   AI113660   AI114265   AI114312   AI134213   AI135002   AI238374   AI258520   AI258574   AI258876   AI259903   AI260054   AI260407   AI293801   AI294958   AI295686   AI389005   AI389018   AI402592   AI403708   AI404147   AI404419   AI404589   AI405188   AI405721   AI455126   AI456129   AI456530   AI456617   AI456757   AI511960   AI512401   AI513198   AI514330   AI514521   AI514539   AI514795   AI514812   AI514897   AI515242   AI515244   AI515808   AI516096   AI516220   AI516251   AI516490   AI516801   AI517842   AI517960   AI518616   AI518617   AI518694   AI519035   AI519109   AI519322   AI519325   AI519342   AI519506   AI519508   AI519780   AI520336   AI530860   AI531362   AI531363   AI531470   AI531872   AI533061   AI533359   AI534474   AI541795   AI542483   AI542572   AI542911   AI543637   AI543876   AI544097   AI544170   AI544252   AI544253   AI945588   AI945813   AQ026184   AQ026337   AQ073043   AQ073893   AQ254887   AX260087   AY058505 AAL13734   AY231783   BE662147   BE662226   BE975225   BE977049   BF485961   BF494630   BF497722   BF502174   BF502934   BF503718   BG640395   BG640607   BI161507   BI161508   BI163740   BI164208   BI165518   BI166175   BI166470   BI167109   BI168084   BI169742   BI171037   BI172155   BI172226   BI173072   BI173089   BI173466   BI173841   BI212760   BI214829   BI215384   BI216310   BI216960   BI228321   BI230523   BI230761   BI232940   BI236071   BI237463   BI239304   BI240022   BI241774   BI241901   BI242690   BI243856   BI352776   BI352953   BI354592   BI354718   BI355473   BI355509   BI356744   BI356808   BI357323   BI358535   BI361683   BI362588   BI363501   BI367253   BI368608   BI368826   BI369296   BI371845   BI372647   BI373057   BI373214   BI373958   BI374063   BI374571   BI374575   BI375224   BI375599   BI481565   BI481784   BI482657   BI483152   BI483172   BI484643   BI610730   BI626260   BI626535   BI632910   BI633866   BI637585   BI638481   BI638590   BI638805   BI639084   BI639790   BI640901   BI641386   BI641387   BP540455   BP540456   BP542673   BP542705   BP544007   BP544008   BP545769   BP548570   BP548927   BP548928   BP551856   BP551990   BP551991   BP556946   BP556947   BP558216   BQ102810   BT014928   CA806121   CA806610   CA807105   CA807564   CA807834   CK132203   CK132893   CK657475   CK660069   CK660667   CK660859   CK661782   CK661953   CL844387   CO156268   CO177095   CO179614   CO184235   CO188765   CO189981   CO190835   CO192619   CO192915   CO267004   CO268374   CO268821   CO270816   CO273122   CO287606   CO288508   CO295584   CO295943   CO301965   CO305184   CO307894   CO307904   CO312807   CO316769   CO321463   CO322257   CO327136   CO328457   CO329885   CO339241   CO339337   CO341184   CZ467237   CZ470294   CZ472113   CZ472191   CZ472405   CZ472406   CZ476335   CZ477206   CZ487952   CZ487953   DQ440242   EC061742   EC062936   EC063997   EC069555   EC069973   EC074089   EC075453   EC085994   EC086086   EC088712   EC196137   EC202548   EC203688   EC204016   EC207410   EC207614   EC209265   EC213710   EC218235   EC225369   EC227224   EC230149   EC231630   EC236175   EC240356   EC241120   EC243782   EC247159   EC248412   EC248852   EC251714   EC254083   EC256483   EC257606   EC257646   EC261207   EL874861   EL874862   EL877011   EV576195   EV581740   EV582174   EV587667   EV589443   EV592387   EV596475   EV597432   EV597756   EV600448   GH847296   GH942708   GH942888   GH947550   GH949296   GH949958   GH949988   GH952474   GH953571   GH956686   GH957920   GH962703   GH964019   GH967780   GH976727   GH981360   GH982227
UniProtKB/Swiss-Prot	Q9VNE2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
axon inferred from direct assay (Lee et al., 2007) cytoplasm inferred from direct assay (Wang et al., 2006) neuronal cell body inferred from direct assay (Lee et al., 2007)
Expression Deduced from Reporters
Reporter: P{GAL4}exbakrasavietz Stage Tissue/Position (including subcellular localization) Reference adult stage   central nervous system   (Dubnau et al., 2003) local interneuron of adult antennal lobe   (Chou et al., 2010) local interneuron of adult antennal lobe | subset   (Das et al., 2008, Shang et al., 2007, Acebes et al., 2011) Kenyon cell | subset   (Shang et al., 2007, Chou et al., 2010) GABAergic neuron | subset   (Shang et al., 2007) cholinergic neuron | subset   (Shang et al., 2007) GABAergic adult AL LN | subset   (Chou et al., 2010) Comment:12 of 16 labeled neurons cholinergic adult AL LN   (Acebes et al., 2011) Comment:6-8 per antennal lobe adult antennal lobe projection neuron   (Acebes et al., 2011) lobe system of mushroom body   (Acebes et al., 2011) mushroom body spur   (Acebes et al., 2011) dopaminergic PPL1 neuron | subset   (Acebes et al., 2011) adult mushroom body   (Dubnau et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    403 central nervous system, larvae L3    427 central nervous system, pupae P8    306 head, virgin 1-day female    326 head, virgin 4-day female    242 head, virgin 20-day female    190 head, mated 1-day female    259 head, mated 4-day female    226 head, mated 20-day female    194 head, mated 1-day male    267 head, mated 4-day male    314 head, mated 20-day male    309 salivary gland, larvae L3 wandering    143 salivary gland, white prepupae    323 digestive system, larvae L3 wandering    427 digestive system, 1-day adult    183 digestive system, 4-day adult    254 digestive system, 20-day adult    132 fat body, larvae L3 wandering    179 fat body, white prepupae    301 fat body, pupae P8    575 carcass, larvae L3 wandering    466 carcass, 1-day adult    238 carcass, 4-day adult    294 carcass, 20-day adult    197 ovary, virgin 4-day female    591 ovary, mated 4-day female    514 testis, mated 4-day male    225 accessory gland, mated 4-day male    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (403) central nervous system, larvae L3  (427) central nervous system, pupae P8  (306) head, virgin 1-day female  (326) head, virgin 4-day female  (242) head, virgin 20-day female  (190) head, mated 1-day female  (259) head, mated 4-day female  (226) head, mated 20-day female  (194) head, mated 1-day male  (267) head, mated 4-day male  (314) head, mated 20-day male  (309) salivary gland, larvae L3 wandering  (143) salivary gland, white prepupae  (323) digestive system, larvae L3 wandering  (427) digestive system, 1-day adult  (183) digestive system, 4-day adult  (254) digestive system, 20-day adult  (132) fat body, larvae L3 wandering  (179) fat body, white prepupae  (301) fat body, pupae P8  (575) carcass, larvae L3 wandering  (466) carcass, 1-day adult  (238) carcass, 4-day adult  (294) carcass, 20-day adult  (197) ovary, virgin 4-day female  (591) ovary, mated 4-day female  (514) testis, mated 4-day male  (225) accessory gland, mated 4-day male  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (403) central nervous system, larvae L3  (427) central nervous system, pupae P8  (306) head, virgin 1-day female  (326) head, virgin 4-day female  (242) head, virgin 20-day female  (190) head, mated 1-day female  (259) head, mated 4-day female  (226) head, mated 20-day female  (194) head, mated 1-day male  (267) head, mated 4-day male  (314) head, mated 20-day male  (309) salivary gland, larvae L3 wandering  (143) salivary gland, white prepupae  (323) digestive system, larvae L3 wandering  (427) digestive system, 1-day adult  (183) digestive system, 4-day adult  (254) digestive system, 20-day adult  (132) fat body, larvae L3 wandering  (179) fat body, white prepupae  (301) fat body, pupae P8  (575) carcass, larvae L3 wandering  (466) carcass, 1-day adult  (238) carcass, 4-day adult  (294) carcass, 20-day adult  (197) ovary, virgin 4-day female  (591) ovary, mated 4-day female  (514) testis, mated 4-day male  (225) accessory gland, mated 4-day male  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    403 central nervous system, larvae L3    427 central nervous system, pupae P8    306 head, virgin 1-day female    326 head, virgin 4-day female    242 head, virgin 20-day female    190 head, mated 1-day female    259 head, mated 4-day female    226 head, mated 20-day female    194 head, mated 1-day male    267 head, mated 4-day male    314 head, mated 20-day male    309 salivary gland, larvae L3 wandering    143 salivary gland, white prepupae    323 digestive system, larvae L3 wandering    427 digestive system, 1-day adult    183 digestive system, 4-day adult    254 digestive system, 20-day adult    132 fat body, larvae L3 wandering    179 fat body, white prepupae    301 fat body, pupae P8    575 carcass, larvae L3 wandering    466 carcass, 1-day adult    238 carcass, 4-day adult    294 carcass, 20-day adult    197 ovary, virgin 4-day female    591 ovary, mated 4-day female    514 testis, mated 4-day male    225 accessory gland, mated 4-day male    164 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    403 central nervous system, larvae L3    427 central nervous system, pupae P8    306 head, virgin 1-day female    326 head, virgin 4-day female    242 head, virgin 20-day female    190 head, mated 1-day female    259 head, mated 4-day female    226 head, mated 20-day female    194 head, mated 1-day male    267 head, mated 4-day male    314 head, mated 20-day male    309 salivary gland, larvae L3 wandering    143 salivary gland, white prepupae    323 digestive system, larvae L3 wandering    427 digestive system, 1-day adult    183 digestive system, 4-day adult    254 digestive system, 20-day adult    132 fat body, larvae L3 wandering    179 fat body, white prepupae    301 fat body, pupae P8    575 carcass, larvae L3 wandering    466 carcass, 1-day adult    238 carcass, 4-day adult    294 carcass, 20-day adult    197 ovary, virgin 4-day female    591 ovary, mated 4-day female    514 testis, mated 4-day male    225 accessory gland, mated 4-day male    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (403) central nervous system, larvae L3  (427) central nervous system, pupae P8  (306) head, virgin 1-day female  (326) head, virgin 4-day female  (242) head, virgin 20-day female  (190) head, mated 1-day female  (259) head, mated 4-day female  (226) head, mated 20-day female  (194) head, mated 1-day male  (267) head, mated 4-day male  (314) head, mated 20-day male  (309) salivary gland, larvae L3 wandering  (143) salivary gland, white prepupae  (323) digestive system, larvae L3 wandering  (427) digestive system, 1-day adult  (183) digestive system, 4-day adult  (254) digestive system, 20-day adult  (132) fat body, larvae L3 wandering  (179) fat body, white prepupae  (301) fat body, pupae P8  (575) carcass, larvae L3 wandering  (466) carcass, 1-day adult  (238) carcass, 4-day adult  (294) carcass, 20-day adult  (197) ovary, virgin 4-day female  (591) ovary, mated 4-day female  (514) testis, mated 4-day male  (225) accessory gland, mated 4-day male  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (403) central nervous system, larvae L3  (427) central nervous system, pupae P8  (306) head, virgin 1-day female  (326) head, virgin 4-day female  (242) head, virgin 20-day female  (190) head, mated 1-day female  (259) head, mated 4-day female  (226) head, mated 20-day female  (194) head, mated 1-day male  (267) head, mated 4-day male  (314) head, mated 20-day male  (309) salivary gland, larvae L3 wandering  143 salivary gland, white prepupae  (323) digestive system, larvae L3 wandering  (427) digestive system, 1-day adult  (183) digestive system, 4-day adult  (254) digestive system, 20-day adult  132 fat body, larvae L3 wandering  (179) fat body, white prepupae  (301) fat body, pupae P8  (575) carcass, larvae L3 wandering  (466) carcass, 1-day adult  (238) carcass, 4-day adult  (294) carcass, 20-day adult  (197) ovary, virgin 4-day female  (591) ovary, mated 4-day female  (514) testis, mated 4-day male  (225) accessory gland, mated 4-day male  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    403 central nervous system, larvae L3    427 central nervous system, pupae P8    306 head, virgin 1-day female    326 head, virgin 4-day female    242 head, virgin 20-day female    190 head, mated 1-day female    259 head, mated 4-day female    226 head, mated 20-day female    194 head, mated 1-day male    267 head, mated 4-day male    314 head, mated 20-day male    309 salivary gland, larvae L3 wandering    143 salivary gland, white prepupae    323 digestive system, larvae L3 wandering    427 digestive system, 1-day adult    183 digestive system, 4-day adult    254 digestive system, 20-day adult    132 fat body, larvae L3 wandering    179 fat body, white prepupae    301 fat body, pupae P8    575 carcass, larvae L3 wandering    466 carcass, 1-day adult    238 carcass, 4-day adult    294 carcass, 20-day adult    197 ovary, virgin 4-day female    591 ovary, mated 4-day female    514 testis, mated 4-day male    225 accessory gland, mated 4-day male    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    247 embryo 02-04hr    344 embryo 04-06hr    263 embryo 06-08hr    230 embryo 08-10hr    256 embryo 10-12hr    211 embryo 12-14hr    344 embryo 14-16hr    141 embryo 16-18hr    163 embryo 18-20hr    100 embryo 20-22hr    114 embryo 22-24hr    161 larva L1    133 larva L2    211 larva L3 12hr old    128 larva L3 puffstage 1-2    131 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    282 white prepupae new    252 white prepupae 12hr    172 white prepupae 24hr    157 pupae 2d postWPP    160 pupae 3d postWPP    145 pupae 4d postWPP    113 adult male 01day    140 adult male 05day    118 adult male 30day    88 adult female 01day    114 adult female 05day    287 adult female 30day    262 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (247) embryo 02-04hr  (344) embryo 04-06hr  (263) embryo 06-08hr  (230) embryo 08-10hr  (256) embryo 10-12hr  (211) embryo 12-14hr  (344) embryo 14-16hr  (141) embryo 16-18hr  (163) embryo 18-20hr  (100) embryo 20-22hr  (114) embryo 22-24hr  (161) larva L1  (133) larva L2  (211) larva L3 12hr old  (128) larva L3 puffstage 1-2  (131) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (282) white prepupae new  (252) white prepupae 12hr  (172) white prepupae 24hr  (157) pupae 2d postWPP  (160) pupae 3d postWPP  (145) pupae 4d postWPP  (113) adult male 01day  (140) adult male 05day  (118) adult male 30day  (88) adult female 01day  (114) adult female 05day  (287) adult female 30day  (262) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (247) embryo 02-04hr  (344) embryo 04-06hr  (263) embryo 06-08hr  (230) embryo 08-10hr  (256) embryo 10-12hr  (211) embryo 12-14hr  (344) embryo 14-16hr  (141) embryo 16-18hr  (163) embryo 18-20hr    100 embryo 20-22hr  (114) embryo 22-24hr  (161) larva L1  (133) larva L2  (211) larva L3 12hr old  (128) larva L3 puffstage 1-2  (131) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (282) white prepupae new  (252) white prepupae 12hr  (172) white prepupae 24hr  (157) pupae 2d postWPP  (160) pupae 3d postWPP  (145) pupae 4d postWPP  (113) adult male 01day  (140) adult male 05day  (118) adult male 30day    88 adult female 01day  (114) adult female 05day  (287) adult female 30day  (262) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    247 embryo 02-04hr    344 embryo 04-06hr    263 embryo 06-08hr    230 embryo 08-10hr    256 embryo 10-12hr    211 embryo 12-14hr    344 embryo 14-16hr    141 embryo 16-18hr    163 embryo 18-20hr    100 embryo 20-22hr    114 embryo 22-24hr    161 larva L1    133 larva L2    211 larva L3 12hr old    128 larva L3 puffstage 1-2    131 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    282 white prepupae new    252 white prepupae 12hr    172 white prepupae 24hr    157 pupae 2d postWPP    160 pupae 3d postWPP    145 pupae 4d postWPP    113 adult male 01day    140 adult male 05day    118 adult male 30day    88 adult female 01day    114 adult female 05day    287 adult female 30day    262 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    247 embryo 02-04hr    344 embryo 04-06hr    263 embryo 06-08hr    230 embryo 08-10hr    256 embryo 10-12hr    211 embryo 12-14hr    344 embryo 14-16hr    141 embryo 16-18hr    163 embryo 18-20hr    100 embryo 20-22hr    114 embryo 22-24hr    161 larva L1    133 larva L2    211 larva L3 12hr old    128 larva L3 puffstage 1-2    131 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    282 white prepupae new    252 white prepupae 12hr    172 white prepupae 24hr    157 pupae 2d postWPP    160 pupae 3d postWPP    145 pupae 4d postWPP    113 adult male 01day    140 adult male 05day    118 adult male 30day    88 adult female 01day    114 adult female 05day    287 adult female 30day    262 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (247) embryo 02-04hr  (344) embryo 04-06hr  (263) embryo 06-08hr  (230) embryo 08-10hr  (256) embryo 10-12hr  (211) embryo 12-14hr  (344) embryo 14-16hr  (141) embryo 16-18hr  (163) embryo 18-20hr  (100) embryo 20-22hr  (114) embryo 22-24hr  (161) larva L1  (133) larva L2  (211) larva L3 12hr old  (128) larva L3 puffstage 1-2  (131) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (282) white prepupae new  (252) white prepupae 12hr  (172) white prepupae 24hr  (157) pupae 2d postWPP  (160) pupae 3d postWPP  (145) pupae 4d postWPP  (113) adult male 01day  (140) adult male 05day  (118) adult male 30day  (88) adult female 01day  (114) adult female 05day  (287) adult female 30day  (262) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (247) embryo 02-04hr  (344) embryo 04-06hr  (263) embryo 06-08hr  (230) embryo 08-10hr  (256) embryo 10-12hr  (211) embryo 12-14hr  (344) embryo 14-16hr  141 embryo 16-18hr  (163) embryo 18-20hr    100 embryo 20-22hr  114 embryo 22-24hr  (161) larva L1  133 larva L2  (211) larva L3 12hr old  128 larva L3 puffstage 1-2  131 larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (282) white prepupae new  (252) white prepupae 12hr  (172) white prepupae 24hr  (157) pupae 2d postWPP  (160) pupae 3d postWPP  (145) pupae 4d postWPP  113 adult male 01day  140 adult male 05day  118 adult male 30day    88 adult female 01day  114 adult female 05day  (287) adult female 30day  (262) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    247 embryo 02-04hr    344 embryo 04-06hr    263 embryo 06-08hr    230 embryo 08-10hr    256 embryo 10-12hr    211 embryo 12-14hr    344 embryo 14-16hr    141 embryo 16-18hr    163 embryo 18-20hr    100 embryo 20-22hr    114 embryo 22-24hr    161 larva L1    133 larva L2    211 larva L3 12hr old    128 larva L3 puffstage 1-2    131 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    282 white prepupae new    252 white prepupae 12hr    172 white prepupae 24hr    157 pupae 2d postWPP    160 pupae 3d postWPP    145 pupae 4d postWPP    113 adult male 01day    140 adult male 05day    118 adult male 30day    88 adult female 01day    114 adult female 05day    287 adult female 30day    262 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    303 Schneider line 2 Sg4    235 embryonic 1182-4H    148 embryonic GM2    477 embryonic Kc167    365 embryonic S1    230 embryonic S3    686 leg disc CME L1    349 wing disc CME-W2    492 wing disc ML-DmD8    331 wing disc ML-DmD9    141 wing disc ML-DmD16-c3    342 wing disc ML-DmD21    122 wing disc ML-DmD32    243 haltere disc ML-DmD17-c3    457 eye-antennal disc ML-DmD11    261 antennal disc ML-DmD20-c5    295 mixed discs ML-DmD4-c1    326 CNS ML-DmBG1-c1    448 CNS ML-DmBG2-c2    434 tumorous blood cells mbn2    811 ovary fGS/OSS    148 ovary OSC    378 ovary OSS    213 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (303) Schneider line 2 Sg4  (235) embryonic 1182-4H  (148) embryonic GM2  (477) embryonic Kc167  (365) embryonic S1  (230) embryonic S3  (686) leg disc CME L1  (349) wing disc CME-W2  (492) wing disc ML-DmD8  (331) wing disc ML-DmD9  (141) wing disc ML-DmD16-c3  (342) wing disc ML-DmD21  (122) wing disc ML-DmD32  (243) haltere disc ML-DmD17-c3  (457) eye-antennal disc ML-DmD11  (261) antennal disc ML-DmD20-c5  (295) mixed discs ML-DmD4-c1  (326) CNS ML-DmBG1-c1  (448) CNS ML-DmBG2-c2  (434) tumorous blood cells mbn2  (811) ovary fGS/OSS  (148) ovary OSC  (378) ovary OSS  (213) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (303) Schneider line 2 Sg4  (235) embryonic 1182-4H  (148) embryonic GM2  (477) embryonic Kc167  (365) embryonic S1  (230) embryonic S3  (686) leg disc CME L1  (349) wing disc CME-W2  (492) wing disc ML-DmD8  (331) wing disc ML-DmD9  (141) wing disc ML-DmD16-c3  (342) wing disc ML-DmD21  (122) wing disc ML-DmD32  (243) haltere disc ML-DmD17-c3  (457) eye-antennal disc ML-DmD11  (261) antennal disc ML-DmD20-c5  (295) mixed discs ML-DmD4-c1  (326) CNS ML-DmBG1-c1  (448) CNS ML-DmBG2-c2  (434) tumorous blood cells mbn2  (811) ovary fGS/OSS  (148) ovary OSC  (378) ovary OSS  (213) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    303 Schneider line 2 Sg4    235 embryonic 1182-4H    148 embryonic GM2    477 embryonic Kc167    365 embryonic S1    230 embryonic S3    686 leg disc CME L1    349 wing disc CME-W2    492 wing disc ML-DmD8    331 wing disc ML-DmD9    141 wing disc ML-DmD16-c3    342 wing disc ML-DmD21    122 wing disc ML-DmD32    243 haltere disc ML-DmD17-c3    457 eye-antennal disc ML-DmD11    261 antennal disc ML-DmD20-c5    295 mixed discs ML-DmD4-c1    326 CNS ML-DmBG1-c1    448 CNS ML-DmBG2-c2    434 tumorous blood cells mbn2    811 ovary fGS/OSS    148 ovary OSC    378 ovary OSS    213 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    303 Schneider line 2 Sg4    235 embryonic 1182-4H    148 embryonic GM2    477 embryonic Kc167    365 embryonic S1    230 embryonic S3    686 leg disc CME L1    349 wing disc CME-W2    492 wing disc ML-DmD8    331 wing disc ML-DmD9    141 wing disc ML-DmD16-c3    342 wing disc ML-DmD21    122 wing disc ML-DmD32    243 haltere disc ML-DmD17-c3    457 eye-antennal disc ML-DmD11    261 antennal disc ML-DmD20-c5    295 mixed discs ML-DmD4-c1    326 CNS ML-DmBG1-c1    448 CNS ML-DmBG2-c2    434 tumorous blood cells mbn2    811 ovary fGS/OSS    148 ovary OSC    378 ovary OSS    213 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (303) Schneider line 2 Sg4  (235) embryonic 1182-4H  (148) embryonic GM2  (477) embryonic Kc167  (365) embryonic S1  (230) embryonic S3  (686) leg disc CME L1  (349) wing disc CME-W2  (492) wing disc ML-DmD8  (331) wing disc ML-DmD9  (141) wing disc ML-DmD16-c3  (342) wing disc ML-DmD21  (122) wing disc ML-DmD32  (243) haltere disc ML-DmD17-c3  (457) eye-antennal disc ML-DmD11  (261) antennal disc ML-DmD20-c5  (295) mixed discs ML-DmD4-c1  (326) CNS ML-DmBG1-c1  (448) CNS ML-DmBG2-c2  (434) tumorous blood cells mbn2  (811) ovary fGS/OSS  (148) ovary OSC  (378) ovary OSS  (213) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (303) Schneider line 2 Sg4  (235) embryonic 1182-4H  (148) embryonic GM2  (477) embryonic Kc167  (365) embryonic S1  (230) embryonic S3  (686) leg disc CME L1  (349) wing disc CME-W2  (492) wing disc ML-DmD8  (331) wing disc ML-DmD9  141 wing disc ML-DmD16-c3  (342) wing disc ML-DmD21  122 wing disc ML-DmD32  (243) haltere disc ML-DmD17-c3  (457) eye-antennal disc ML-DmD11  (261) antennal disc ML-DmD20-c5  (295) mixed discs ML-DmD4-c1  (326) CNS ML-DmBG1-c1  (448) CNS ML-DmBG2-c2  (434) tumorous blood cells mbn2  (811) ovary fGS/OSS  (148) ovary OSC  (378) ovary OSS  (213) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    303 Schneider line 2 Sg4    235 embryonic 1182-4H    148 embryonic GM2    477 embryonic Kc167    365 embryonic S1    230 embryonic S3    686 leg disc CME L1    349 wing disc CME-W2    492 wing disc ML-DmD8    331 wing disc ML-DmD9    141 wing disc ML-DmD16-c3    342 wing disc ML-DmD21    122 wing disc ML-DmD32    243 haltere disc ML-DmD17-c3    457 eye-antennal disc ML-DmD11    261 antennal disc ML-DmD20-c5    295 mixed discs ML-DmD4-c1    326 CNS ML-DmBG1-c1    448 CNS ML-DmBG2-c2    434 tumorous blood cells mbn2    811 ovary fGS/OSS    148 ovary OSC    378 ovary OSS    213 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult    244 Cadmium 50 mM 6 hrs, larvae L3    152 Cadmium 50 mM 12 hrs, larvae L3    459 Cadmium 50 mM 48 hrs, 4-day adult    285 Cadmium 100 mM 48 hrs, 4-day adult    485 Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult    1072 Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult    513 Ethanol 2.5% 3 hrs, larvae L3    279 Ethanol 5% 3 hrs, larvae L3    239 Ethanol 10% 3 hrs, larvae L3    198 Caffeine 1.5 mg/ml 4 hrs, larvae L3    202 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    457 Caffeine 25 mg/ml 48 hrs, 4-day adult    133 Paraquat 5 mM 48 hrs, 4-day adult    359 Paraquat 10 mM 48 hrs, 4-day adult    234 Rotenone 2 μg 12 hrs, larvae L3    426 Rotenone 8 μg 12 hrs, larvae L3    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (89) cold shock, 4-day adult  (77) heat shock, 4-day adult  (244) Cadmium 50 mM 6 hrs, larvae L3  (152) Cadmium 50 mM 12 hrs, larvae L3  (459) Cadmium 50 mM 48 hrs, 4-day adult  (285) Cadmium 100 mM 48 hrs, 4-day adult  (485) Copper 0.5 mM 12 hrs, larvae L3  (61) Copper 15 mM 48 hrs, 4-day adult  (1072) Zinc 5 mM 12 hrs, larvae L3  (94) Zinc 4.5 mM 48 hrs, 4-day adult  (513) Ethanol 2.5% 3 hrs, larvae L3  (279) Ethanol 5% 3 hrs, larvae L3  (239) Ethanol 10% 3 hrs, larvae L3  (198) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (202) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (457) Caffeine 25 mg/ml 48 hrs, 4-day adult  (133) Paraquat 5 mM 48 hrs, 4-day adult  (359) Paraquat 10 mM 48 hrs, 4-day adult  (234) Rotenone 2 μg 12 hrs, larvae L3  (426) Rotenone 8 μg 12 hrs, larvae L3  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult  (244) Cadmium 50 mM 6 hrs, larvae L3  (152) Cadmium 50 mM 12 hrs, larvae L3  (459) Cadmium 50 mM 48 hrs, 4-day adult  (285) Cadmium 100 mM 48 hrs, 4-day adult  (485) Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult  (1072) Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult  (513) Ethanol 2.5% 3 hrs, larvae L3  (279) Ethanol 5% 3 hrs, larvae L3  (239) Ethanol 10% 3 hrs, larvae L3  (198) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (202) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (457) Caffeine 25 mg/ml 48 hrs, 4-day adult  (133) Paraquat 5 mM 48 hrs, 4-day adult  (359) Paraquat 10 mM 48 hrs, 4-day adult  (234) Rotenone 2 μg 12 hrs, larvae L3  (426) Rotenone 8 μg 12 hrs, larvae L3  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult    244 Cadmium 50 mM 6 hrs, larvae L3    152 Cadmium 50 mM 12 hrs, larvae L3    459 Cadmium 50 mM 48 hrs, 4-day adult    285 Cadmium 100 mM 48 hrs, 4-day adult    485 Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult    1072 Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult    513 Ethanol 2.5% 3 hrs, larvae L3    279 Ethanol 5% 3 hrs, larvae L3    239 Ethanol 10% 3 hrs, larvae L3    198 Caffeine 1.5 mg/ml 4 hrs, larvae L3    202 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    457 Caffeine 25 mg/ml 48 hrs, 4-day adult    133 Paraquat 5 mM 48 hrs, 4-day adult    359 Paraquat 10 mM 48 hrs, 4-day adult    234 Rotenone 2 μg 12 hrs, larvae L3    426 Rotenone 8 μg 12 hrs, larvae L3    151 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult    244 Cadmium 50 mM 6 hrs, larvae L3    152 Cadmium 50 mM 12 hrs, larvae L3    459 Cadmium 50 mM 48 hrs, 4-day adult    285 Cadmium 100 mM 48 hrs, 4-day adult    485 Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult    1072 Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult    513 Ethanol 2.5% 3 hrs, larvae L3    279 Ethanol 5% 3 hrs, larvae L3    239 Ethanol 10% 3 hrs, larvae L3    198 Caffeine 1.5 mg/ml 4 hrs, larvae L3    202 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    457 Caffeine 25 mg/ml 48 hrs, 4-day adult    133 Paraquat 5 mM 48 hrs, 4-day adult    359 Paraquat 10 mM 48 hrs, 4-day adult    234 Rotenone 2 μg 12 hrs, larvae L3    426 Rotenone 8 μg 12 hrs, larvae L3    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (89) cold shock, 4-day adult  (77) heat shock, 4-day adult  (244) Cadmium 50 mM 6 hrs, larvae L3  (152) Cadmium 50 mM 12 hrs, larvae L3  (459) Cadmium 50 mM 48 hrs, 4-day adult  (285) Cadmium 100 mM 48 hrs, 4-day adult  (485) Copper 0.5 mM 12 hrs, larvae L3  (61) Copper 15 mM 48 hrs, 4-day adult  (1072) Zinc 5 mM 12 hrs, larvae L3  (94) Zinc 4.5 mM 48 hrs, 4-day adult  (513) Ethanol 2.5% 3 hrs, larvae L3  (279) Ethanol 5% 3 hrs, larvae L3  (239) Ethanol 10% 3 hrs, larvae L3  (198) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (202) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (457) Caffeine 25 mg/ml 48 hrs, 4-day adult  (133) Paraquat 5 mM 48 hrs, 4-day adult  (359) Paraquat 10 mM 48 hrs, 4-day adult  (234) Rotenone 2 μg 12 hrs, larvae L3  (426) Rotenone 8 μg 12 hrs, larvae L3  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult  (244) Cadmium 50 mM 6 hrs, larvae L3  (152) Cadmium 50 mM 12 hrs, larvae L3  (459) Cadmium 50 mM 48 hrs, 4-day adult  (285) Cadmium 100 mM 48 hrs, 4-day adult  (485) Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult  (1072) Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult  (513) Ethanol 2.5% 3 hrs, larvae L3  (279) Ethanol 5% 3 hrs, larvae L3  (239) Ethanol 10% 3 hrs, larvae L3  (198) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (202) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (457) Caffeine 25 mg/ml 48 hrs, 4-day adult  133 Paraquat 5 mM 48 hrs, 4-day adult  (359) Paraquat 10 mM 48 hrs, 4-day adult  (234) Rotenone 2 μg 12 hrs, larvae L3  (426) Rotenone 8 μg 12 hrs, larvae L3  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    89 cold shock, 4-day adult    77 heat shock, 4-day adult    244 Cadmium 50 mM 6 hrs, larvae L3    152 Cadmium 50 mM 12 hrs, larvae L3    459 Cadmium 50 mM 48 hrs, 4-day adult    285 Cadmium 100 mM 48 hrs, 4-day adult    485 Copper 0.5 mM 12 hrs, larvae L3    61 Copper 15 mM 48 hrs, 4-day adult    1072 Zinc 5 mM 12 hrs, larvae L3    94 Zinc 4.5 mM 48 hrs, 4-day adult    513 Ethanol 2.5% 3 hrs, larvae L3    279 Ethanol 5% 3 hrs, larvae L3    239 Ethanol 10% 3 hrs, larvae L3    198 Caffeine 1.5 mg/ml 4 hrs, larvae L3    202 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    457 Caffeine 25 mg/ml 48 hrs, 4-day adult    133 Paraquat 5 mM 48 hrs, 4-day adult    359 Paraquat 10 mM 48 hrs, 4-day adult    234 Rotenone 2 μg 12 hrs, larvae L3    426 Rotenone 8 μg 12 hrs, larvae L3    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD21309 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250753
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal exbaCB02125 lethal | pupal stage, with Scer\GAL4pnr-MD237 exbaGD8839 lethal | recessive exba03022 exbaj9B6 partially lethal - majority die exba03022 viable exbaEY11022 exbaf05932 Sterility Allele female sterile | germline clone exba1 fertile exbaEY11022 exbaf05932 Other Phenotypes Allele chemical resistant exbakrasavietz memory defective exbakrasavietz neuroanatomy defective | embryonic stage (with exba1) exba2 neuroanatomy defective | embryonic stage (with exba2) exba1 Phenotype manifest in Allele axon & pCC neuron (with exba1) exba2 axon & pCC neuron (with exba2) exba1
Classical Alleles ( 33 )
For All Classical Alleles Show
Allele of exba Class Mutagen Stocks Known lesion exbaf05932 piggyBac transposase 2 -- exbaj9B6 P-element activity 2 -- exba03022 P-element activity 1 -- exba5-SZ-3068 1 -- exbac01538 piggyBac transposase 1 -- exbac05843 piggyBac transposase 1 -- exbaCB-0923-3 1 -- exbaCB-5654-3 1 -- exbaCB-5753-3 1 -- exbaCB-6007-3 1 -- exbad01235 P-element activity 1 -- exbad01372 P-element activity 1 -- exbaEY11022 P-element activity 1 -- exbaf05390 piggyBac transposase 1 -- exbaNP2078 1 -- exbaNP3229 1 -- exbaNP3614 1 -- exba1 P-element activity 0 Yes exba2 P-element activity 0 Yes exba5-HA-2635 0 -- exbaBA00280 piggyBac transposase 0 Yes exbaCB02125 P-element activity 0 Yes exbaCTG-240.1 P-element activity 0 Yes exbad01733 P-element activity 0 -- exbad02932 0 -- exbad08623 P-element activity 0 -- exbad10311 P-element activity 0 -- exbaEP3297 P-element activity 0 -- exbaEP3591 P-element activity 0 -- exbaEP428 P-element activity 0 Yes exbaf06989 0 -- exbakrasavietz P-element activity 0 -- exbaunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of exba Class Mutagen Stocks Known lesion exbaGD8839 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes exbaGL00690 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes exbaJF02556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes exbaKK102900 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes exba12A.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes exba7A.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes exbaNIG.2922R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes exbaScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)ED5177 (Roote, 2004.7.20) Df(3R)Exel6144 (Ryder, 2004.4.26)
Not disrupted in	Df(3R)ED5177 (Ryder and Roote, 2004.11.10)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8839} NA P{KK102900} NA P{NIG.2922R} NA P{TRiP.GL00690} NA P{TRiP.JF02556} NA P{UAS-kra.HA.7A} NA P{UAS-kra.HA.12A} NA P{UAS-kra.HA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}exbaEP428 NA P{EP}exbaEP3297 NA P{EP}exbaEP3591 NA P{EPgy2}exbaEY11022 NA P{XP}exbad01235 NA P{XP}exbad01372 NA P{XP}exbad01733 NA P{XP}exbad02932 NA P{XP}exbad08623 NA P{XP}exbad10311 NA miscellaneous insertions P{PTT-GB}exbaCB02125 NA P{RS3}exbaCB-0923-3 NA P{RS3}exbaCB-5654-3 NA P{RS3}exbaCB-5753-3 NA P{RS3}exbaCB-6007-3 NA P{RS5}exba5-HA-2635 NA P{RS5}exba5-SZ-3068 NA P{UASp-CTG.240}exbaCTG-240.1 NA PBac{HpaI-GFP.A}exbaBA00280 NA PBac{PB}exbac01538 NA PBac{PB}exbac05843 NA PBac{WH}exbaf05390 NA PBac{WH}exbaf05932 NA PBac{WH}exbaf06989 NA insertion of enhancer trap binary system P{GAL4}exbakrasavietz No P{GawB}exbaNP2078 No P{GawB}exbaNP3229 No P{GawB}exbaNP3614 No insertion of enhancer trap P{lacW}exbaj9B6 No P{PZ}exba03022 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with eIF-2β (Lee et al., 2007) inferred from physical interaction with RpL5 (Wang et al., 2006) inferred from physical interaction with shot (Lee et al., 2007) ribosome binding inferred from direct assay (Wang et al., 2006) translation initiation factor binding inferred from direct assay (Lee et al., 2007)
Biological Process
CV term Evidence References
axon midline choice point recognition inferred from mutant phenotype (Lee et al., 2007) behavioral response to ethanol inferred from mutant phenotype (Berger et al., 2008) long-term memory inferred from mutant phenotype (Dubnau et al., 2003, Akalal et al., 2011) negative regulation of translation inferred from direct assay (Lee et al., 2007) neuron fate commitment inferred from mutant phenotype (Lee et al., 2002) oogenesis inferred from mutant phenotype (Lee et al., 2007)
Cellular Component
CV term Evidence References
axon inferred from direct assay (Lee et al., 2007) cytoplasm inferred from direct assay (Wang et al., 2006) neuronal cell body inferred from direct assay (Lee et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
long-term memory traceable author statement (Greenspan, 2003) RNA metabolic process inferred from electronic annotation with InterPro:IPR016021 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
exba - CG13887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) exba - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) exba - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) exba - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) exba - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions exba allele Gene References exba03022 Kr (Carrera et al., 1998) unspecified robo (Lee et al., 2007) shot (Lee et al., 2007) sli (Lee et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65886 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250753 DroID - A comprehensive database of gene and protein interactions. • FBgn0250753 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40680
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QZ85R Dipteran inclusive ortholog search EOG608NHK Insect inclusive ortholog search EOG6ZS7ZN Arthropod inclusive ortholog search EOG6MCVFT Metazoa inclusive ortholog search EOG65N100
Orthologs in Drosophila Species (EOG6QZ85R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\exba     Drosophila simulans   Dsim\GD19602 Y   Drosophila sechellia   Dsec\GM10614 Y   Drosophila erecta   Dere\GG10932 Y   Drosophila yakuba   Dyak\GE24159 Y   Drosophila ananassae   Dana\GF20763 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15521 Y   Drosophila persimilis   Dper\GL22291 Y   Drosophila willistoni   Dwil\GK22654 Y   Drosophila virilis   Dvir\GJ24012 Y   Drosophila mojavensis   Dmoj\GI23920 Y   Drosophila grimshawi   Dgri\GH17376 Y
Orthologs in non-Drosophila Dipterans (EOG608NHK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015512   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012026   Anopheles gambiae Malaria mosquito  Agam\AGAP002413   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006749
Orthologs in non-Dipteran Insects (EOG6ZS7ZN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002237   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21349   Atta cephalotes Leafcutter ant  Acep\ACEP11556   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13254   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21274   Linepithema humile Argentine ant  Lhum\LH20303   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23726   Solenopsis invicta Red fire ant  Sinv\SINV19948   Solenopsis invicta Red fire ant  Sinv\SINV19950   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006482   Bombyx mori Silkmoth  Bmor\BGIBMGA008682   Pediculus humanus Human body louse  Phum\PHUM450110   Tribolium castaneum Red flour beetle  Tcas\TC030783
Orthologs in non-Insect Arthropods (EOG6MCVFT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_198197   Ixodes scapularis Deer tick  Isca\ISCW005690
Orthologs in non-Arthropod Metazoa (EOG65N100)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022080gn   Danio rerio Zebrafish  Drer\ENSDARG00000034961   Danio rerio Zebrafish  Drer\bzw2   Danio rerio Zebrafish  Drer\bzw1a   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030733   Xenopus tropicalis Western clawed frog  Xtro\bzw2   Gallus gallus Domestic chicken  Ggal\BZW2   Gallus gallus Domestic chicken  Ggal\BZW1   Mus musculus House mouse  Mmus\Bzw2   Mus musculus House mouse  Mmus\Bzw1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003181   Rattus norvegicus Norway rat  Rnor\Bzw2   Rattus norvegicus Norway rat  Rnor\Bzw1   Homo sapiens Human  Hsap\BZW2   Homo sapiens Human  Hsap\BZW1
Human Orthologs (2)
Gene OMIM HGNC Hsap\BZW2     Hsap\BZW1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19602 Drosophila sechellia Dsec\GM10614 Drosophila erecta Dere\GG10932 Drosophila yakuba Dyak\GE24159 Drosophila ananassae Dana\GF20763 Drosophila pseudoobscura pseudoobscura Dpse\GA15521 Drosophila persimilis Dper\GL22291 Drosophila willistoni Dwil\GK22654 Drosophila virilis Dvir\GJ24012 Drosophila mojavensis Dmoj\GI23920 Drosophila grimshawi Dgri\GH17376
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Bloomington	18919 w1118; PBac{WH}exbaf05932
Harvard	- P{XP}exbad01235 - P{XP}exbad01372 - PBac{PB}exbac01538 - PBac{PB}exbac05843 - PBac{WH}exbaf05390 - PBac{WH}exbaf05932
Kyoto	113170 w*; P{GawB}exbaNP3229 113372 w*; P{GawB}exbaNP3614
VDRC	v102609 P{KK102900}VIE-260B v25166 w1118; P{GD8839}v25166 v25165 w1118; P{GD8839}v25165/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR03P13 BACR24O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 396 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT07276 LD21309
Other clones	DPiM_LD21309 yak-em_CG2922
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03331 AT04896 AT11982 AT17823 AT18793 AT20066 GH01765 GH02804 GH04185 GH04415 GH05118 GH05604 GH06127 GH06130 GH07122 GH07694 GH08394 GH10064 GH11121 GH11607 GH14408 GH20074 GH20091 GH21840 GH23207 GH23753 GH25123 GM01404 GM02976 GM03553 GM03622 GM04860 GM08749 GM08895 GM08970 GM09093 GM09954 GM10773 GM14078 GM20731 GM21430 GM27536 GM28032 GM30939 GM31161 LD02980 LD07716 LD07846 LD07859 LD08289 LD08458 LD08685 LD10107 LD12290 LD12671 LD14028 LD14989 LD17023 LD19316 LD19388 LD19795 LD19908 LD22907 LD24044 LD24074 LD24501 LD24614 LD25329 LD25525 LD26487 LD27144 LD27257 LD28456 LD28485 LD28591 LD28861 LD29210 LD29473 LD29663 LD29952 LD29974 LD32063 LD32831 LD33026 LD34772 LD36878 LD37309 LD39125 LD40110 LD41056 LD41080 LD42018 LD42918 LD45415 LD46484 LD46511 LD46525 LD46981 LD46983 LP01739 LP01801 LP02174 LP03731 LP04245 LP07026 LP09384 LP13542 LP18316 LP19430 LP19790 LP21494 LP23806 RE03229 RE11009 RE14218 RE38938 RE43759 RE59658 RE63451 RE64138 RE64385 RH66828 SD01606 SD02361 SD02363 SD02527 SD03155 SD04755 SD05147 SD06971 SD07320 SD08823 SD08961 SD09426 SD10505 SD10743 SD10744 SD11403 SD11732 SD19635 SD20777 SD20921 SD21189 SD21533 SD22467 SD23927 SD24667 SD24668 SD26812 SD28042
Other clones	9259 9643 38802 56562 60631 62490 63751 73654 76831 77135 79877 103264 103398 105350 105493 119797 125707 150113 161382 172899 214281.57 214307.57 214413.64 214413.66 214539.60 527320 bs14e08 bs17b08 bs24h10 bs32b12 bs40b05 bs59c03 CK01.16D.A10 CK01.50D.E9 CK01.56D.A4 CK01.62A.H10 CK01.64C.E6 CK01.76A.C12 CK01.76D.F3 CK01.83A.H12 CK01.87A.D8 CK01.121C.G9 Dmel_dig_013631_0697_3057 Dmel_dig_015206_0701_3134 Dmel_dig_021030_0675_0840 Dmel_neb_000947_0923_3687 Dmel_neb_001039_0419_0357 Dmel_neb_001188_0947_3608 Dmel_neb_007456_0633_3686 Dmel_neb_009163_0920_0550 Dmel_neb_011892_0090_0957 Dmel_neb_014636_0950_1235 EC27444 EC34161 EC34774 EK041817 EK045834 EK049863 EK052439 EK060022 EK066264 EK068648 EK091204 EK092827 EK100403 EK109644 EK148301 EK182806 EK185730 EK187743 EK210755 EK212344 EK230016 EK247616 EK255957 EK256109 EK265826 EK294107 EN07664 EP01312 EP01636 EP05926 EP09234 EP12014 ESG012a.E21_D05 ESG014a.E21_G02 ESG016b.E21_C06 ESG018c.E21.1_B08 ESG019d.E21_E05 FGA004F06 FGC015F05 FGC016A02 FGC023E12 FGC033D02 FGH129B09 FGM002F06 FGM215C03 FGM216A04 FGM306D11 FGM313F12 GH01186 GH01865 GH02867 GH11060 GH12611 GH24125 GH24354 GH25839 HL01857 IP06947 IP14941 LD01852 LD02952 LD03948 LD06029 LD06512 LD07702 LD09372 LD10048 LD10510 LD12820 LD13387 LD13513 LD14338 LD15118 LD15903 LD16104 LD19819 LD20148 LD20363 LD20950 LD20983 LD24626 LD24863 LD25768 LD26858 LD27458 LD29011 LD32159 LD33545 LD33674 LD34346 LD34589 LD34682 LD35983 LD36576 LD36695 LD38140 LD38231 LD38232 LD38371 LD38525 LD38864 LD38868 LD38887 LD39123 LD39553 LD40468 LD41480 LD41851 LD42049 LD42376 LD42872 LD43546 LD44268 LD45540 LD46330 LD47619 LP03424 LP08451 LP21787 RE01014 RE03836 RE05437 RE06217 RE06601 RE07419 RE08627 RE12690 RE14429 RE14528 RE14794 RE15819 RE15828 RE16402 RE16960 RE18005 RE20960 RE21769 RE23403 RE24459 RE25833 RE29091 RE32065 RE33691 RE35761 RE36664 RE39101 RE40088 RE41653 RE42945 RE43030 RE45329 RE46010 RE47188 RE48326 RE52972 RE54610 RE54867 RE55432 RE58852 RE60269 RE60455 RE61434 RE61575 RE62196 RE62206 RE62975 RE65374 RE65994 RE66021 RE67777 RH16407 RH67509 RP003643440 RP004047768 RP004073708 RP004127354 RP004144169 RP004178544 RP004178787 RP004188469 RP004207353 RP004222427 RP004232287 RP004255488 RP004256350 RP004313175 RP004462968 RP004508842 RP004522424 UUGC0198
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0250753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40680
Antibody Information
Other Information
Discoverer
	L. and Y. Jan.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eIF-5C CG2922 (FlyBase, 1996-)
Source for database merge of	Source for merge of: eIF-5C anon-WO0172774.49 (FlyBase, 1996-) Source for merge of: eIF-5C extra-bases (Lee et al., 2003) Source for merge of: eIF-5C l(3)03022 (Levis, 2002.6.24) Source for merge of: exba l(3)j9B6 (Lee et al., 2007)
Additional comments	Source for merge of eIF-5C anon-WO0172774.49 was sequence comparison (date:051113). (FlyBase, 1996-) Source for identity of eIF-5C CG2922 was sequence comparison (date:010210). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Lee et al., 2007) exba has a role in long-term memory. (Dubnau et al., 2003) exba is required for lineage specification in the nervous system. (Lee et al., 2002) Mutants produce extra neurons. (Lee et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079514 NM_169074 NM_169075 NM_169076 NM_169077 NM_169078 NM_169079 RefSeq (Proteins) • NP_524238 NP_730958 NP_730959 NP_730960 NP_730961 NP_730962 NP_730963 DDBJ / EMBL / GenBank • AA391055 AA439703 AA697033 AA735439 AAF51995 AAF51996 AAG22214 AAK01218 AAL13734 AAN13246 AAN13247 AAN13248 AAN13249 AF325529 AI403708 AI455126 AI456129 AI945588 AI945813 AQ026184 AQ026337 AQ073043 AQ073893 AQ254887 AX260087 AY058505 BE662147 BE662226 CL844387 CZ467237 CZ470294 CZ472113 CZ472191 CZ472405 CZ472406 CZ476335 CZ477206 CZ487952 CZ487953 Entrez Gene - A searchable database of RefSeq genes. • 40680 UniProtKB/Swiss-Prot • Q9VNE2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • W2 domain (IPR003307) Armadillo-type fold (IPR016024) MIF4-like, type 1/2/3 (IPR016021) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD21309
Linkouts
	BioGRID - A database of protein and genetic interactions • 65886 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250753 DroID - A comprehensive database of gene and protein interactions. • FBgn0250753 DRSC - Results from RNAi screens. • FBgn0250753 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250753 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0250753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40680 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40680 modMine - Data generated by the modENCODE project. • FBgn0250753
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	anon-WO0172774.49   CG2922 (Le Mée et al., 2008, Lee et al., 2003, Huang et al., 2005, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Muse et al., 2007, Ling and Salvaterra, 2011, Ni et al., 2010.12.1) CT7240 (Ceriani et al., 2002) Decp (Wan, 2000.11.30) ecp (Wang et al., 2006) eIF (Buszczak et al., 2007) eIF5 (Bottenberg et al., 2009) eIF-5C (Margulies et al., 2005, Jasper et al., 2002, Roote, 2004.7.20, Greenspan, 2003, Bellen et al., 2004, Dubnau et al., 2003, FlyBase, 1996-, Dubnau et al., 2003, Levis, 2002.6.24, Buszczak et al., 2007, Quinones-Coello, 2007, Gilchrist et al., 2008, Rehwinkel et al., 2005, Berger et al., 2008) eIf-5c (Ganguly-Fitzgerald et al., 2006) eiF-5C (Quinones-Coello, 2007) eIF-5c (Hartmann et al., 2011) eIF5c (Devineni and Heberlein, 2010) elF-5C (Ryder and Roote, 2004.11.10, Muse et al., 2007) elF5C (Sanchez-Soriano et al., 2009) elf-5C (Muse et al., 2007) exba (Arancio et al., 2010, Devineni and Heberlein, 2010, Weake et al., 2011, Perkins et al., 2009.8.10, Devineni and Heberlein, 2009, Weake et al., 2009, Bartkowiak et al., 2010, Ling and Salvaterra, 2011, Berger et al., 2008, Japanese National Institute of Genetics, 2012.5.21) Exba (Lee et al., 2007) kra (Lee et al., 2007, Sanchez-Soriano et al., 2009, Bottenberg et al., 2009, Devineni and Heberlein, 2009) Kra (Lee et al., 2007) l(3)03022 (Spradling et al., 1999, Carrera et al., 1998, BDGP Project Members, 1994-1999, ) l(3)j9B6
Name Synonym	Drosophila eIF5C-containing protein (Wan, 2000.11.30) eukaryotic initiation factor 5C   extra bases (Lee et al., 2002) extra-bases (Lee et al., 2003, ) extra bses (Hartmann et al., 2011) krasavietz (Huang et al., 2010, Yaksi and Wilson, 2010, Dubnau et al., 2003, Hartmann et al., 2011, Krashes et al., 2009, Devineni and Heberlein, 2009, Berger et al., 2008) Krasavietz (Lee et al., 2007, Devineni and Heberlein, 2010, Sanchez-Soriano et al., 2009, Bottenberg et al., 2009, Seki et al., 2010) lethal (3) j9B6
Secondary FlyBase IDs
	FBgn0010791 FBgn0011418 FBgn0037346 FBgn0046382 FBgn0061514
References ( 73 )
Generate a list of	All references relating to this gene ( 73 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Note  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Patent  ( 1 )
Recent research papers ( 6 )
	Acebes et al., 2011, J. Neurosci. 31(8): 2734--2745 Synapse loss in olfactory local interneurons modifies perception. [FBrf0213264] Akalal et al., 2011, J. Neurosci. 31(15): 5643--5647 The Long-Term Memory Trace Formed in the Drosophila {alpha}/{beta} Mushroom Body Neurons Is Abolished in Long-Term Memory Mutants. [FBrf0213484] Hartmann et al., 2011, RNA 17(3): 453--468 Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. [FBrf0212988] Kazama et al., 2011, J. Neurosci. 31(21): 7619--7630 Cell Death Triggers Olfactory Circuit Plasticity via Glial Signaling in Drosophila. [FBrf0213815] Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...