FlyBase Gene Report: Dmel\kra

General Information

Symbol

Dmel\kra

Species

D. melanogaster

Name

krasavietz

Annotation Symbol

CG2922

Feature Type

protein_coding_gene

FlyBase ID

FBgn0250753

Gene Model Status

Current

Stock Availability

26 publicly available

Gene Snapshot

Krasavietz (Kra) is a translational regulator that is able to interact with the translation initiation factor eIF-2β. Kra is involved in axon guidance, long-term memory, and alcohol addiction. [Date last reviewed: 2016-09-01]

Other Summaries

Auto summary
UniProtKB
Interactive Fly

Also Known As

exba, eIF-5C, l(3)03022, ECP, elF-5C

Key Links

Genomic Location

Cytogenetic map

83B4-83B4

Sequence location

3R:5,595,364..5,601,136 [-]

Recombination map

3-47.5

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI Genome Data Viewer

UCSC Genome Browser

Ensembl Genome Browser

PopFly Genome Browser

GO Summary Ribbons

[Detailed GO annotations]

Families, Domains and Molecular Function

Gene Group Membership (FlyBase)

Protein Family (UniProt, Sequence Similarities)

Belongs to the BZW family. (Q9VNE2)

Protein Domains/Motifs

InterPro

W2 domain; MIF4G-like domain superfamily; Armadillo-type fold

Molecular Function (see GO section for details)

Experimental Evidence

protein binding; ribosomal small subunit binding; ribosome binding; translation initiation factor binding

Predictions / Assertions

Summaries

UniProt Contributed Function Data

May be involved in memory formation.

(UniProt, Q9VNE2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\kra or the JBrowse view of Dmel\kra for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kra-RA

FBtr0078744

NM_169074

2123

422

kra-RB

FBtr0078749

NM_169075

1847

422

kra-RC

FBtr0078746

NM_169076

1906

422

kra-RD

FBtr0078748

NM_169077

2026

422

kra-RE

FBtr0078750

NM_169078

1701

422

kra-RF

FBtr0078747

NM_169079

1776

422

kra-RG

FBtr0078745

NM_079514

1614

422

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

kra-PA

FBpp0078393

49.2

422

5.46

NP_730958

AAF51996

kra-PB

FBpp0078398

49.2

422

5.46

NP_730959

AAG22214

kra-PC

FBpp0078395

49.2

422

5.46

NP_730960

AAF51995

kra-PD

FBpp0078397

49.2

422

5.46

NP_730961

AAN13246

kra-PE

FBpp0078399

49.2

422

5.46

NP_730962

AAN13247

kra-PF

FBpp0078396

49.2

422

5.46

NP_730963

AAN13248

kra-PG

FBpp0078394

49.2

422

5.46

NP_524238

AAN13249

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

422 aa isoforms: kra-PA, kra-PB, kra-PC, kra-PD, kra-PE, kra-PF, kra-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VNE2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kra using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kra_1

Linkouts

Gene Ontology (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

protein binding

inferred from physical interaction with FLYBASE:shot; FB:FBgn0013733

(Lee et al., 2007)

inferred from physical interaction with FLYBASE:RpL5; FB:FBgn0064225

(Wang et al., 2006)

ribosomal small subunit binding

inferred from direct assay

(Lee et al., 2007)

ribosome binding

inferred from direct assay

(Wang et al., 2006)

translation initiation factor binding

inferred from physical interaction with FLYBASE:eIF2β; FB:FBgn0004926

(Lee et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

axon midline choice point recognition

inferred from mutant phenotype

(Lee et al., 2007)

behavioral response to ethanol

inferred from mutant phenotype

(Berger et al., 2008)

long-term memory

inferred from mutant phenotype

(Akalal et al., 2011)

inferred from mutant phenotype

(assigned by UniProt )

(Dubnau et al., 2003)

negative regulation of translation

inferred from direct assay

(Lee et al., 2007)

oogenesis

inferred from mutant phenotype

(Lee et al., 2007)

ovarian follicle cell development

inferred from mutant phenotype

(Jia et al., 2015)

positive regulation of filopodium assembly

inferred from mutant phenotype

(Sanchez-Soriano et al., 2009)

inferred from genetic interaction with FLYBASE:shot; FB:FBgn0013733

(Sanchez-Soriano et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

long-term memory

traceable author statement

(Greenspan, 2003)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

axon

inferred from direct assay

(Lee et al., 2007)

axonal growth cone

inferred from direct assay

(Sanchez-Soriano et al., 2009)

cytoplasm

inferred from direct assay

(Wang et al., 2006)

filopodium

inferred from direct assay

(Sanchez-Soriano et al., 2009)

neuronal cell body

inferred from direct assay

(Sanchez-Soriano et al., 2009, Lee et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000368070

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

axon

inferred from direct assay

(Lee et al., 2007)

axonal growth cone

inferred from direct assay

(Sanchez-Soriano et al., 2009)

cytoplasm

inferred from direct assay

(Wang et al., 2006)

filopodium

inferred from direct assay

(Sanchez-Soriano et al., 2009)

neuronal cell body

inferred from direct assay

(Sanchez-Soriano et al., 2009, Lee et al., 2007)

Expression Deduced from Reporters

Reporter: P{GAL4}kra^krasavietz

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

intrinsic neuron of embryonic/larval antennal lobe

(Thum et al., 2011)

adult stage

central nervous system

(Dubnau et al., 2003)

local interneuron of adult antennal lobe

(Chou et al., 2010)

local interneuron of adult antennal lobe | subset

Comment: 6-8 per antennal lobe

(Acebes et al., 2011, Das et al., 2008, Shang et al., 2007)

Kenyon cell | subset

(Chou et al., 2010, Shang et al., 2007)

GABAergic neuron | subset

(Shang et al., 2007)

cholinergic neuron | subset

(Shang et al., 2007)

GABAergic local interneuron of the adult antennal lobe | subset

Comment: 12 of 16 labeled neurons

(Chou et al., 2010)

cholinergic local interneuron of the adult antennal lobe

Comment: 6-8 per antennal lobe

(Acebes et al., 2011)

adult antennal lobe projection neuron

(Acebes et al., 2011)

lobe system of mushroom body

(Acebes et al., 2011)

mushroom body spur

(Acebes et al., 2011)

dopaminergic PPL1 neuron | subset

(Acebes et al., 2011)

adult mushroom body

(Dubnau et al., 2003)

mushroom body extrinsic neuron | subset

(Cervantes-Sandoval et al., 2016)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kra in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kra

View exonic expression by tissue for Dmel\kra

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250753

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0250753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2922

Flygut - An atlas of the Drosophila adult midgut

FBgn0250753

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs and Phenotypes

Classical and Insertion Alleles ( 35 )

For All Classical and Insertion Alleles Show

Allele of kra

Class

Mutagen

Associated Insertion

Stocks

Known lesion

kra⁰³⁰²²

P-element activity

P{PZ}kra⁰³⁰²²

Yes

kra^krasavietz

P-element activity

P{GAL4}kra^krasavietz

kra²

P-element activity

Yes

kra^j9B6

P-element activity

P{lacW}kra^j9B6

Yes

kra¹

P-element activity

Yes

kra^EP428

P-element activity

P{EP}kra^EP428

Yes

kra^f05932

piggyBac activity

Yes

Yes

piggyBac activity

PBac{IT.GAL4}kra^0506-G4

Yes

kra^c01538

piggyBac activity

PBac{PB}kra^c01538

Yes

kra^c05843

piggyBac activity

Yes

Yes

Yes

Yes

Yes

P-element activity

P{XP}kra^d01235

Yes

kra^d01372

P-element activity

P{XP}kra^d01372

Yes

kra^EY11022

P-element activity

P{EPgy2}kra^EY11022

Yes

kra^f05390

piggyBac activity

Yes

Yes

Yes

Yes

piggyBac activity

PBac{HpaI-GFP.A}kra^YD0086

Yes

kra^5-HA-2635

P{RS5}kra^5-HA-2635

Yes

kra^BA00280

piggyBac activity

PBac{HpaI-GFP.A}kra^BA00280

Yes

kra^CB02125

P-element activity

P{PTT-GB}kra^CB02125

Yes

kra^CTG-240.1

P-element activity

P{UASp-CTG.240}kra^CTG-240.1

Yes

kra^d01733

P-element activity

Yes

Yes

P-element activity

P{XP}kra^d08623

Yes

kra^d10311

P-element activity

P{XP}kra^d10311

Yes

kra^EP3297

P-element activity

P{EP}kra^EP3297

Yes

kra^EP3591

P-element activity

Yes

Yes

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kra

Allele of kra

Mutagen

Associated Transgenic Construct

Stocks

Transgenic constructs containing regulatory region of kra

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)ED5177

(Roote, 2004.7.20)

Df(3R)Exel6144

(Ryder, 2004.4.26)

Not disrupted in

Df(3R)ED5177

(Ryder and Roote, 2004.11.10)

Summary of Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

kra^CB02125

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

kra^GD8839

partially lethal - majority die

kra⁰³⁰²²

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kra^GD8839

viable, with Scer\GAL4^tin.CΔ4

kra^GD8839

Sterility

Allele

female sterile | germline clone

kra¹

fertile

Other Phenotypes

Allele

chemical resistant

kra^krasavietz

memory defective

kra^krasavietz

neuroanatomy defective (with kra¹)

kra²

neuroanatomy defective (with kra²)

kra¹

neuroanatomy defective | embryonic stage (with kra¹)

kra²

neuroanatomy defective | embryonic stage (with kra²)

kra¹

some die during pupal stage, with Scer\GAL4^pnr-MD237

kra^GD8839

Phenotype manifest in

Allele

axon & pCC neuron (with kra¹)

kra²

axon & pCC neuron (with kra²)

kra¹

filopodium (with kra¹)

kra²

filopodium (with kra²)

kra¹

neuron (with kra¹)

kra²

neuron (with kra²)

kra¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BZW1

14 of 15

Yes

Hsap\BZW2

12 of 15

Yes

Hsap\EIF5

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Bzw1

14 of 15

Yes

Mmus\Bzw2

11 of 15

Yes

Mmus\Eif5

1 of 15

Rattus norvegicus (Norway rat) (2)

Rnor\Bzw1

13 of 13

Yes

Rnor\Bzw2

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\bzw1

5 of 12

Yes

Xtro\bzw2

5 of 12

Yes

Xtro\eif4g2

1 of 12

Danio rerio (Zebrafish) (3)

Drer\bzw1a

14 of 15

Yes

Drer\bzw1b

12 of 15

Yes

Drer\bzw2

12 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\C37C3.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT1G65220

8 of 9

Yes

Atha\AT5G36230

8 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TIF5

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\tif225

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908YO )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\kra

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15521

Drosophila persimilis

Dper\GL22291

Drosophila willistoni

Dwil\GK22654

Drosophila virilis

Dvir\GJ24012

Drosophila mojavensis

Dmoj\GI23920

Drosophila grimshawi

Dgri\GH17376

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505HM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018533

Glossina morsitans

Tsetse fly

Gmor\GMOY001920

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_14223

Mayetiola destructor

Hessian fly

Mdes\Mdes002223

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015512

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012026

Anopheles darlingi

American malaria mosquito

Adar\ADAC001271

Anopheles gambiae

Malaria mosquito

Agam\AGAP002413

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006749

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06K2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008682

Danaus plexippus

Monarch butterfly

Dple\DPOGS215203-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL009664

Apis florea

Little honeybee

Aflo\2485214948

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18224

Bombus terrestris

Buff-tailed bumblebee

Bter\15210743

Linepithema humile

Argentine ant

Lhum\LH20303

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000a1b

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002237

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12646

Tribolium castaneum

Red flour beetle

Tcas\TC030783

Pediculus humanus

Human body louse

Phum\PHUM450110

Rhodnius prolixus

Kissing bug

Rpro\RPRC007462

Cimex lectularius

Bed bug

Clec\CLEC005867

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006482

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02743

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16149

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05VQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR006628

Ixodes scapularis

Black-legged tick

Isca\ISCW005690

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79503.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74754.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_198197

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G090E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bzw1

Gallus gallus

Domestic chicken

Ggal\BZW2

Gallus gallus

Domestic chicken

Ggal\BZW1

Human Disease Model Data

FlyBase Human Disease Model Reports

alcohol, response to, learning and memory genes

Alleles Reported to Model Human Disease (Disease Ontology)

Download

Models ( 0 )

Allele

Disease

Evidence

References

Interactions ( 0 )

Allele

Disease

Interaction

References

Comments ( 0 )

Human Orthologs (via DIOPT v7.1)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

Complementation?

Transgene?

BZW1; basic leucine zipper and W2 domains 1

14 of 15

BZW2; basic leucine zipper and W2 domains 2

12 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions

protein-protein

Interacting group

Assay

References

kra - Gapdh1

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - Gapdh2

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - RpL5

anti bait coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot, pull down, western blot

(Wang et al., 2006)

kra - RpL7A

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - RpS4

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - RpS8

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - RpS9

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

kra - eIF2β

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Lee et al., 2007)

kra - shot

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Lee et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kra

enhanceable

shot

(Lee et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

kra

(Carrera et al., 1998)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65886

DroID - A comprehensive database of gene and protein interactions.

FBgn0250753

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40680

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83B4-83B4

Sequence location

3R:5,595,364..5,601,136 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B4-83B4

Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

83B4-83B4

(Wan, 2000.11.30)

83B1-83B5

(determined by in situ hybridisation)

(Spradling et al., 1999)

83B4-83B2

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (26)

Bloomington

18919

w¹¹¹⁸; PBac{WH}kra^f05932

d01235

d01372

c01538

c05843

f05390

f05932

113170

w^*; P{GawB}kra^NP3229

113372

w^*; P{GawB}kra^NP3614

VDRC

v102609

P{KK102900}VIE-260B

v25166

w¹¹¹⁸; P{GD8839}v25166

v25165

w¹¹¹⁸; P{GD8839}v25165/TM3

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (391)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

DPiM_LD21309

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0250753

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0250753

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40680

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Li et al., 2015, Lee et al., 2007, Wang et al., 2006)

monoclonal

(Wang et al., 2006)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: eIF-5C CG2922

(FlyBase, 1996-)

Source for identity of: kra exba

(Lee et al., 2007)

Source for database merge of

Source for merge of: eIF-5C l(3)03022

(Levis, 2002.6.24)

Source for merge of: eIF-5C extra-bases

(Lee et al., 2003)

Source for merge of: exba l(3)j9B6

(Lee et al., 2007)

Source for merge of: eIF-5C anon-WO0172774.49

(FlyBase, 1996-)

Additional comments

FlyBase curator comment: Originally named 'exba/extra bases' according to ADRC abstracts from the Lee group (FBrf0146421, FBrf0157123), but changed to 'kra/krasavietz' based on preference indicated in subsequently published research paper (FBrf0201378) by same group.

(Lee et al., 2007)

Source for identity of eIF-5C CG2922 was sequence comparison ( date:010210 ).

(FlyBase, 1996-)

Source for merge of eIF-5C anon-WO0172774.49 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene.

(Lee et al., 2007)

exba has a role in long-term memory.

(Dubnau et al., 2003)

exba is required for lineage specification in the nervous system.

(Lee et al., 2002)

Mutants produce extra neurons.

(Lee et al., 2002)

Origin and Etymology

Discoverer

L. and Y. Jan.

Etymology

Identification

External Crossreferences and Linkouts ( 74 )

Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40680

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VNE2

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250753

InterPro - A database of protein families, domains and functional sites

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10216-exba[j9B6]

BioGRID - A database of protein and genetic interactions.

65886

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones

FBgn0250753

DPiM - Drosophila Protein interaction map

FBgn0250753

DroID - A comprehensive database of gene and protein interactions.

FBgn0250753

DRSC - Results frm RNAi screens

FBgn0250753

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kra_1

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0250753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2922

Flygut - An atlas of the Drosophila adult midgut

FBgn0250753

FlyMine - An integrated database for Drosophila genomics

FBgn0250753

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40680

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40680

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2922

modMine - A data warehouse for the modENCODE project

FBgn0250753

Synonyms and Secondary IDs (35)

Reported As

Symbol Synonym

5MP

(Kozel et al., 2016)

CG2922

(Kolkhof et al., 2017, Schwartz et al., 2016, Hosono et al., 2015, Ling and Salvaterra, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Le Mée et al., 2008, Muse et al., 2007, Quinones-Coello, 2007, Huang et al., 2005, Lee et al., 2003)

CT7240

(Ceriani et al., 2002)

Decp

(Wan, 2000.11.30)

ECP

(Wang et al., 2014, Zhao et al., 2012, Wang et al., 2006)

Ecp

(Li et al., 2015)

Exba

(Lee et al., 2007)

Kra

(Voelzmann et al., 2017, Carvajal-Gonzalez et al., 2016, Kaun et al., 2012, Das et al., 2010, Lee et al., 2007)

anon-WO0172774.49

chr3R:1423015..1423173

(Will et al., 2013)

eIF

(Buszczak et al., 2007)

eIF-5C

(Berger et al., 2008, Gilchrist et al., 2008, Buszczak et al., 2007, Quinones-Coello, 2007, Margulies et al., 2005, Rehwinkel et al., 2005, Bellen et al., 2004, Roote, 2004.7.20, Dubnau et al., 2003, Dubnau et al., 2003, Greenspan, 2003, Jasper et al., 2002, Levis, 2002.6.24, FlyBase, 1996-)

eIF-5c

(Hartmann et al., 2011)

eIF5

(Bottenberg et al., 2009)

eIF5c

(Devineni and Heberlein, 2010)

eIf-5c

(Ganguly-Fitzgerald et al., 2006)

ecp

(Wang et al., 2006)

eiF-5C

(Quinones-Coello, 2007)

elF-5C

(Muse et al., 2007, Ryder and Roote, 2004.11.10)

elF5C

(Sanchez-Soriano et al., 2009)

elf-5C

(Muse et al., 2007)

exba

(Stegeman et al., 2016, Jia et al., 2015, Ashwal-Fluss et al., 2014, Robinson and Atkinson, 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Winbush et al., 2012, Chung et al., 2011, Ling and Salvaterra, 2011, Weake et al., 2011, Arancio et al., 2010, Bartkowiak et al., 2010, Devineni and Heberlein, 2010, Devineni and Heberlein, 2009, Perkins et al., 2009.8.10, Weake et al., 2009, Berger et al., 2008, Marygold et al., 2007)

exba/kra

(Angrisani et al., 2015)

kra

(Park et al., 2017, Clandinin and Owens, 2016-, Kaun et al., 2012, Awofala, 2011, Bottenberg et al., 2009, Devineni and Heberlein, 2009, Sanchez-Soriano et al., 2009, Lee et al., 2007, Lee et al., 2007)

l(3)03022

(Spradling et al., 1999, Carrera et al., 1998, BDGP Project Members, 1994-1999)

l(3)j9B6

Name Synonyms

Drosophila eIF5C-containing protein

(Wan, 2000.11.30)

Krasavietz

(Marygold et al., 2017, Das et al., 2010, Devineni and Heberlein, 2010, Seki et al., 2010, Bottenberg et al., 2009, Sanchez-Soriano et al., 2009, Lee et al., 2007)

eIF5-mimic protein

(Kozel et al., 2016)

eukaryotic initiation factor 5C

extra bases

(Lee et al., 2002)

extra bses

(Hartmann et al., 2011)

extra-bases

(Lee et al., 2003)

krasavietz

(Carvajal-Gonzalez et al., 2016, Kaun et al., 2012, Awofala, 2011, Hartmann et al., 2011, Huang et al., 2010, Yaksi and Wilson, 2010, Devineni and Heberlein, 2009, Krashes et al., 2009, Berger et al., 2008, Dubnau et al., 2003)

lethal (3) j9B6

Secondary FlyBase IDs

FBgn0061514
FBgn0046382
FBgn0010791
FBgn0037346
FBgn0011418

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (114)

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