l(2)03953, szar, 38E.21
Essential septate junction gene encoding a membrane associated guanylate kinase (MAGUK) - required for accumulation of the tracheal size-control proteins Vermiform and Serpentine in the tracheal lumen
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Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
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Comment: maternally deposited
vari protein expression was detected from embryonic stage 13-17 and is observed in septate junctions in epithelial tissues including the epidermis, trachea, proventriculus, salivary gland and hindgut. In larvae, vari protein is observed in the neurepithelium of the optic lobe and in central brain neuroblasts in third instar larvae. In the adult nervous system, vari localizes to a subset of differentiated neurons surrounding neuropile regions.
vari protein is predominantly expressed in the septate junctions in trachea and hindgut by embryonic stage 14 but is also detected in the dorsal epidermis as early as stage 12. It is also observed in salivary gland in stages 15,16.
GBrowse - Visual display of RNA-Seq signals
View Dmel\vari in GBrowse 22-54
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: vari l(2)03953
Source for identity of: szar CG9326
Source for merge of: vari szar l(2)38EFa
vari is required for septate junction formation in the tracheal system.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutation in vari alters tracheal tube size in embryos without affecting other aspects of tracheal development including primary branch budding and outgrowth or branch fusion.
The gene is named "senz'aria", the Italian for "airless", as the trachea fail to inflate in mutant embryos.