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Gene Dmel\Chd1

General Information
Symbol	Dmel\Chd1	Species	D. melanogaster
Name	Chromodomain-helicase-DNA-binding protein 1	Annotation symbol	CG3733
Feature type	protein_coding_gene	FlyBase ID	FBgn0250786
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CHD-1, dCHD1
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	23C4-23C4	Sequence location	2L:2,979,699..2,987,677 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Chromodomain-helicase-DNA-binding protein 1 is referred to in FlyBase by the symbol Dmel\Chd1 (CG3733, FBgn0250786). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: fertilization, exchange of chromosomal proteins; oogenesis; imaginal disc-derived wing morphogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; wing; male pronucleus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Chromo domain; Chromo domain, conserved site; Chromo domain-like; Chromo domain/shadow; DEAD-like helicase; DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; Helicase, C-terminal; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639816_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Chd1. Gene sequence location is 2L:2979699..2987677.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA00745 BKN21926
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23C4-23C4   Limits computationally determined from genome sequence between P{PZ}lilli00632 and P{PZ}toc01361
Experimentally Determined Cytological Location
Cytogenetic map Notes References 23C-24A   (determined by in situ hybridisation)   (Stokes et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Stokes et al., 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Chd1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 DGC clone appears problematic (LD39323): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Chd1-RA FBtr0077674  NM_057849   6286   1883 Chd1-RB FBtr0305980     6216   1900
Additional Transcript Data & Comments
Reported size (kB)	7 (northern blot) (Stokes et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Chd1-PA   FBpp0077358   211.8   1883   6.30     NP_477197   AAF51170 Chd1-PB   FBpp0297122   213.9   1900   6.41
Additional Polypeptide Data & Comments
Reported size (kDa)	1883 (aa); 200~210 (kD observed); 211 (kD predicted) (Stokes et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DEAD-like helicase (IPR014001) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase, C-terminal (IPR001650) Chromo domain/shadow (IPR000953) SNF2-related (IPR000330) Chromo domain-like (IPR016197) Chromo domain, conserved site (IPR023779) Chromo domain (IPR023780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51170   AC010009   AC092187   AI519660   AW943464   AY095050 AAM11378   BI352757   BI639048   BP542537   BP552690   BT011071   BT056280   BT059798   BT125065   CA807418   CK604535   CK604536   CK605179   CK605180   CK605289   CK605290   CO184391   CO265337   CO280149   CO284765   CO302815   CO303258   CO312365   CO320497   CO330427   CO336422   EC051475   EC052618   EC054605   EC055918   EC056356   EC061775   EC067214   EC076216   EC210572   EC222761   EC227906   EC233326   EC246390   EC265076   EV576200   L77907 AAC37264   Z50480
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SWV9 Q7KU24
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & adult stage     (Stokes et al., 1996)
Additional Descriptive Data
	Chd1 transcripts are observed in late embryo and adult RNA on northern blots. (Stokes et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	polytene chromosome (Stokes et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0250786    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0250786 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0250786 expression level Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6688) embryo 02-04hr  (3546) embryo 04-06hr  (3146) embryo 06-08hr  (3732) embryo 08-10hr  (3180) embryo 10-12hr  (2701) embryo 12-14hr  (1988) embryo 14-16hr  (2068) embryo 16-18hr  (1941) embryo 18-20hr  (2007) embryo 20-22hr  (1729) embryo 22-24hr  (1636) larva L1  (1636) larva L2  (1086) larva L3 12hr old  (1014) larva L3 puffstage 1-2  (775) larva L3 puffstage 3-6  (1196) larva L3 puffstage 7-9  (1251) white prepupae new  (1270) white prepupae 12hr  (1664) white prepupae 24hr  (2060) pupae 2d postWPP  (1454) pupae 3d postWPP  (1104) pupae 4d postWPP  (1206) adult male 01day  (1209) adult male 05day  (1420) adult male 30day  (1412) adult female 01day  (2759) adult female 05day  (4160) adult female 30day  (4415) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6688) embryo 02-04hr  (3546) embryo 04-06hr  (3146) embryo 06-08hr  (3732) embryo 08-10hr  (3180) embryo 10-12hr  (2701) embryo 12-14hr  (1988) embryo 14-16hr  (2068) embryo 16-18hr  (1941) embryo 18-20hr  (2007) embryo 20-22hr  (1729) embryo 22-24hr  (1636) larva L1  (1636) larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr  (1664) white prepupae 24hr  (2060) pupae 2d postWPP  1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day  1420 adult male 30day  1412 adult female 01day  (2759) adult female 05day  (4160) adult female 30day  (4415) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0250786 expression level Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6688) embryo 02-04hr  (3546) embryo 04-06hr  (3146) embryo 06-08hr  (3732) embryo 08-10hr  (3180) embryo 10-12hr  (2701) embryo 12-14hr  (1988) embryo 14-16hr  (2068) embryo 16-18hr  (1941) embryo 18-20hr  (2007) embryo 20-22hr  (1729) embryo 22-24hr  (1636) larva L1  (1636) larva L2  (1086) larva L3 12hr old  (1014) larva L3 puffstage 1-2  (775) larva L3 puffstage 3-6  (1196) larva L3 puffstage 7-9  (1251) white prepupae new  (1270) white prepupae 12hr  (1664) white prepupae 24hr  (2060) pupae 2d postWPP  (1454) pupae 3d postWPP  (1104) pupae 4d postWPP  (1206) adult male 01day  (1209) adult male 05day  (1420) adult male 30day  (1412) adult female 01day  (2759) adult female 05day  (4160) adult female 30day  (4415) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6688) embryo 02-04hr  (3546) embryo 04-06hr  (3146) embryo 06-08hr  (3732) embryo 08-10hr  (3180) embryo 10-12hr  (2701) embryo 12-14hr  1988 embryo 14-16hr  2068 embryo 16-18hr  1941 embryo 18-20hr  2007 embryo 20-22hr  1729 embryo 22-24hr  1636 larva L1  1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr  1664 white prepupae 24hr  2060 pupae 2d postWPP  1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day  1420 adult male 30day  1412 adult female 01day  (2759) adult female 05day  (4160) adult female 30day  (4415) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6688 embryo 02-04hr    3546 embryo 04-06hr    3146 embryo 06-08hr    3732 embryo 08-10hr    3180 embryo 10-12hr    2701 embryo 12-14hr    1988 embryo 14-16hr    2068 embryo 16-18hr    1941 embryo 18-20hr    2007 embryo 20-22hr    1729 embryo 22-24hr    1636 larva L1    1636 larva L2    1086 larva L3 12hr old    1014 larva L3 puffstage 1-2    775 larva L3 puffstage 3-6    1196 larva L3 puffstage 7-9    1251 white prepupae new    1270 white prepupae 12hr    1664 white prepupae 24hr    2060 pupae 2d postWPP    1454 pupae 3d postWPP    1104 pupae 4d postWPP    1206 adult male 01day    1209 adult male 05day    1420 adult male 30day    1412 adult female 01day    2759 adult female 05day    4160 adult female 30day    4415 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0250786    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0250786 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0250786 expression level Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0250786 expression level Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    207.8 Larval Midgut    73 Larval Hindgut    107.7 Larval Malpighian Tubules    78.7 Larval Fat Body    63.2 Larval Salivary Gland    163.4 Larval Trachea    102.775 Larval Carcass    94.05 Adult Head    112.7 Adult Eye    88.425 Adult Brain    236.3 Adult Thoracic-Abdominal Ganglion    158.4 Adult Crop    118.7 Adult Midgut    86.4 Adult Hindgut    120.5 Adult Malpighian Tubules    128.7 Adult Fat Body    112.2 Adult Salivary Gland    198.3 Adult Heart    88.175 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    135.7 Adult Ovary    321.6 Adult Testis    88.9 Adult Male Accessory Gland    145.2 Adult Carcass    112.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    112.7   NA  Eye    88.425   NA  Brain    236.3   207.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    158.4   NA  Crop    118.7   73  Midgut    86.4   107.7  Hindgut    120.5   78.7  Malpighian Tubules    128.7   63.2  Fat Body    112.2   163.4  Salivary Gland    198.3   NA  Heart    88.175   102.775  Trachea    NA   NA  VirginFemale Spermatheca    135.6   NA  InseminatedFemale Spermatheca    135.7   NA  Ovary    321.6   NA  Testis    88.9   NA  Male Accessory Gland    145.2   94.05  Carcass    112.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250786
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | non-rescuable maternal effect (with Df(2L)Exel7014) Chd11 Chd12 lethal | embryonic stage | non-rescuable maternal effect | recessive Chd1unspecified lethal | male limited, with Scer\GAL4Act5C.PI Chd1EP lethal | partially (with Df(2L)Exel7014) Chd11 Chd12 lethal | recessive Chd1A7-4 semi-viable (with Df(2L)Exel7014) Chd1unspecified semi-viable (with Df(2L)JS17) Chd1unspecified viable Chd14 Chd15 viable, with Scer\GAL4pnr-MD237 Chd1GD11058 viable (with Chd14) Chd15 viable (with Chd15) Chd14 viable (with Df(2L)Exel7014) Chd14 Chd15 Sterility Allele female sterile (with Df(2L)Exel7014) Chd14 Chd1unspecified female sterile (with Df(2L)JS17) Chd1unspecified female sterile | partially (with Chd14) Chd15 female sterile | partially (with Chd15) Chd14 male sterile (with Chd14) Chd15 male sterile (with Chd15) Chd14 male sterile (with Df(2L)Exel7014) Chd1unspecified male sterile (with Df(2L)JS17) Chd1unspecified Other Phenotypes Allele developmental rate defective Chd14 Chd15 developmental rate defective (with Chd14) Chd15 developmental rate defective (with Chd15) Chd14 developmental rate defective (with Df(2L)Exel7014) Chd14 Chd15 enhancer of variegation, with Dp(?;2)bwD, Scer\GAL4GMR.PF Chd1EP visible, with Scer\GAL4pnr-MD237 Chd1GD11058 visible (with Chd14) Chd15 visible (with Chd15) Chd14 visible (with Df(2L)Exel7014) Chd14 Chd15 Phenotype manifest in Allele male pronucleus (with Df(2L)Exel7014) Chd11 trichogen cell, with Scer\GAL4pnr-MD237 Chd1GD11058 wing (with Chd14) Chd15 wing (with Chd15) Chd14 wing (with Df(2L)Exel7014) Chd14 Chd15
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Chd1 Class Mutagen Stocks Known lesion Chd1A7-4 ethyl methanesulfonate 2 Yes Chd1G7954 P-element activity 1 -- Chd11 P-element activity 0 Yes Chd12 P-element activity 0 Yes Chd14 P-element activity 0 Yes Chd15 P-element activity 0 Yes Chd1EP 0 Yes Chd1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Chd1 Class Mutagen Stocks Known lesion Chd1GD11058 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Chd1GL00126 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Chd1HMS01142 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Chd1KK101875 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Chd1+t8.5 in vitro construct - genomic fragment 0 Yes Chd1CD.T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes Chd1WT.T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)AS2 (Ferro, 2002.12) Df(2L)Exel7014 (Ryder, 2004.4.26) Df(2L)JS17 (Eeken, 2000.2.29, Ferro, 2002.12)
Not disrupted in	Df(2L)16 (Ferro, 2002.12) Df(2L)17 (Ferro, 2002.12) Df(2L)18 (Ferro, 2002.12) Df(2L)19 (Ferro, 2002.12) Df(2L)20 (Ferro, 2002.12) Df(2L)AS8 (Ferro, 2002.12) Df(2L)C28 (Eeken, 2000.2.29, Ferro, 2002.12) Df(2L)C144 (McDaniel, 2006.10.11) Df(2L)JS7 (Eeken, 2000.2.29) Df(2L)JS25 (Ferro, 2002.12) Df(2L)JS27 (Ferro, 2002.12)
Partially disrupted in	Df(2L)Chd11 (Konev et al., 2007) Df(2L)Chd12 (Konev et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11058} NA P{KK101875} NA P{TRiP.GL00126} NA P{TRiP.HMS01142} NA characterization construct P{Chd1.CD} NA P{Chd1.WT} NA P{Chd1+t8.5} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?EP}Chd14 NA P{?EP}Chd15 NA insertion of mobile activating element P{EP}Chd1EP NA P{EP}Chd1G7954 NA P{EP}G2213 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Stokes et al., 1996)
Biological Process
CV term Evidence References
fertilization, exchange of chromosomal proteins inferred from mutant phenotype (Konev et al., 2007) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (McDaniel et al., 2008) oogenesis inferred from mutant phenotype (McDaniel et al., 2008)
Cellular Component
CV term Evidence References
polytene chromosome interband inferred from direct assay (Stokes et al., 1996) polytene chromosome puff inferred from direct assay (Stokes et al., 1996)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001650, InterPro:IPR002464 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from electronic annotation with InterPro:IPR002464 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR000330 (FlyBase Curators et al., 2004-) helicase activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with mouse Chd1 (Stokes et al., 1996)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR000953 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Chd1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59725 DroID - A comprehensive database of gene and protein interactions. • FBgn0250786 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33505
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14337 Dere\GG24470 Dgri\GH10643 Dmoj\GI10771 Dper\GL26702 Dpse\GA17649 Dsec\GM18179 Dsim\GD22786 Dvir\GJ18281 Dwil\GK15574 Dyak\GE14968
Curated drosophilid orthologs	Dpse\GA17649
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004716-PA Aedes aegypti (mosquito) XP_001120496.1 Apis mellifera (honey bee) XP_001946846.1 Acyrthosiphon pisum (pea aphid) At2g13370.1 Arabidopsis thaliana (wall cress) 9456 Batrachochytrium dendrobatidis (chytrid fungus) 266878 Branchiostoma floridae (lancelet) XP_001897230.1 Brugia malayi (roundworm nematode) BGIBMGA003497-PA Bombyx mori (silk worm) ENSBTAP00000034848 Bos taurus (bovine) CAL0001390 Candida albicans (a form of yeast) CN04806 Caenorhabditis brenneri (small nematode) CBP25397 Caenorhabditis briggsae (nematode) CE32454 Caenorhabditis elegans (worm) ENSCAFP00000016310 Canis familiaris (dog) CAGL0L11770g Candida glabrata (haploid yeast) Chro.10413 Cryptosporidium hominis (obligate parasite) ENSCINP00000015797 Ciona intestinalis (sea squirt) JA08431 Caenorhabditis japonica (nematode) CMQ215C Cyanidioschyzon merolae (red alga) cn08103 Cryptococcus neoformans (yeast-like fungus) cgd1_3670 Cryptosporidium parvum (protozoan parasite) CPIJ001937 Culex pipens (mosquito) ENSCPOP00000002998 Cavia porcellus (guinea pig) RP29390 Caenorhabditis remanei (nematode) ENSCSAVP00000012904 Ciona savignyi (sedentary tunicate) 167753 Capitella spl (polychaete worm) DDB0220640 Dictyostelium discoideum (amoeba) DEHA2G12496g Debaryomyces Hansenii (yeast) 227473 Daphnia pulex (daphnia) ENSDARP00000080170 Danio rerio (zebra fish) ENSECAP00000021298 Equus caballus (horse) XP_654639 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000017517 Gymnopilus aculeatus (mushroom) ENSGALP00000011246 Gallus gallus (chicken) 192382 Hypsipyla robusta (cedar shoot borer) ENSP00000377747 Homo sapiens (human) ISCW004121-PA Ixodes scapularis (deer tick) KLLA0C17578g Kluyveromyces lactis (yeast) 218699 Lottia gigantea (owl limpet) LmjF25.2050 Leishmania major (virus) ENSMODP00000016479 Monodelphis domestica (gray opossum) ENSMMUP00000018527 Macaca mulatta (rhesus monkey) ENSMUSP00000024627 Mus musculus (house mouse) 50041 Nematostella vectensis (starlet anemone) ENSOANP00000006945 Ornithorynchus anatinus (platypus) ENSORLP00000010555 Oryzias latipes (japanese killifish) PHUM000821-PA Pediculus humanus (human body louse) 132084 Physcomitrella patens (moss) ENSPPYP00000017508 Pongo pygmaeus (orangutan) 74211 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000012779 Pan troglodytes (chimpanzee) PVX_111520 Plasmodium vivax (protozoal parasite) ENSRNOP00000017144 Rattus norvegicus (norway rat) 5052190 Sorghum bicolor (sorghum) YER164W Saccharomyces cerevisiae (budding yeast) Smp_041760 Schistosoma mansoni (trematode parasite) SPAC3G6.01 Schizosaccharomyces pombe (fission yeast) XP_001181304.1 Strongylocentrotus purpuratus (purple sea urchin) 54568 Trichoplax adhaerens (metazoa) TA06105 Theileria annulata (apicomplexan parasite) XP_970343.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013680 Tetraodon nigroviridis (green spotted pufferfish) TP01_0866 Theileria parva (parasitic protozoan) ENSTRUP00000022210 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000025881 Takifugu rubripes (pufferfish Takifugu) 16.m00319 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000052094 Xenopus tropicalis (frog) YALI0C00363g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10806 NV11865 LH16490 ISCW004121 FBgn0232558 FBgn0217579 FBgn0205442 FBgn0194180 FBgn0173086 JGI_V11_227473 FBgn0077660 FBgn0164283 FBgn0133534 FBgn0118124 FBgn0116602 FBgn0091364 CPIJ001937 BGIBMGA003497 ACYPI003241 GB14981 AGAP008698 AAEL004716 PHUM370270 GLEAN_10805
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	5727 Chd1A7-4 cn1 bw1/CyO 27478 y1 w*; P{EP}Chd1G7954 35240 y1 sc* v1; P{TRiP.GL00126}attP2 34665 y1 sc* v1; P{TRiP.HMS01142}attP2
Kyoto	108390 Chd1A7-4 cn1 bw1/CyO
VDRC	v103640 P{KK101875}VIE-260B v26277 w1118; P{GD11058}v26277
Genomic Clones ( 1 )
	BACR23N06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39323 SD21488
Other clones	MIP01689 MIP03089 MIP05474
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM20615
Other clones	Dmel_dig_018010_0635_0527 EC28026 EC051475 EC052618 EC054605 EC055918 EC056356 EK142321 EK152746 EK166742 EK184942 EK228548 EK240706 EK285745 EK295241 EN12513 ESG017d.E21_E08 FGC014B12 FGM220B12 UT01261 UT01735 UT01815
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0250786 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33505 251962
Antibody Information
	polyclonal (Stokes et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Chd1 l(2)23Cd (Konev et al., 2007)
Additional comments
Other Comments
	Chd1 is required for incorporation of His3.3A protein into the male pronucleus. (Konev et al., 2007) Embryos lacking Chd1 function cannot incorporate His3.3A protein into the male pronucleus, rendering the paternal genome unable to participate in zygotic mitoses and leading to haploid embryos. (Konev et al., 2007) cDNA clones that encode the Drosophila CHD1 homologue are isolated and antibodies raised against a portion demonstrate the protein is concentrated in transcriptionally active regions of the genome. (Stokes et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057849 RefSeq (Proteins) • NP_477197 DDBJ / EMBL / GenBank • AAC37264 AAF51170 AAM11378 AC010009 AC092187 AI519660 AW943464 AY095050 BI639048 L77907 Z50480 Entrez Gene - A searchable database of RefSeq genes. • 33505 UniProtKB/TrEMBL • Q7KU24 Q8SWV9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DEAD-like helicase (IPR014001) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase, C-terminal (IPR001650) Chromo domain/shadow (IPR000953) SNF2-related (IPR000330) Chromo domain-like (IPR016197) Chromo domain, conserved site (IPR023779) Chromo domain (IPR023780)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59725 DroID - A comprehensive database of gene and protein interactions. • FBgn0250786 DRSC - Results from RNAi screens. • FBgn0250786 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250786 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0250786 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33505 251962 InParanoid A subset of ortholog calls from InParanoid. • AAEL004716-PA Aedes aegypti (mosquito) XP_001120496.1 Apis mellifera (honey bee) XP_001946846.1 Acyrthosiphon pisum (pea aphid) At2g13370.1 Arabidopsis thaliana (wall cress) 9456 Batrachochytrium dendrobatidis (chytrid fungus) 266878 Branchiostoma floridae (lancelet) XP_001897230.1 Brugia malayi (roundworm nematode) BGIBMGA003497-PA Bombyx mori (silk worm) ENSBTAP00000034848 Bos taurus (bovine) CAL0001390 Candida albicans (a form of yeast) CN04806 Caenorhabditis brenneri (small nematode) CBP25397 Caenorhabditis briggsae (nematode) CE32454 Caenorhabditis elegans (worm) ENSCAFP00000016310 Canis familiaris (dog) CAGL0L11770g Candida glabrata (haploid yeast) Chro.10413 Cryptosporidium hominis (obligate parasite) ENSCINP00000015797 Ciona intestinalis (sea squirt) JA08431 Caenorhabditis japonica (nematode) CMQ215C Cyanidioschyzon merolae (red alga) cn08103 Cryptococcus neoformans (yeast-like fungus) cgd1_3670 Cryptosporidium parvum (protozoan parasite) CPIJ001937 Culex pipens (mosquito) ENSCPOP00000002998 Cavia porcellus (guinea pig) RP29390 Caenorhabditis remanei (nematode) ENSCSAVP00000012904 Ciona savignyi (sedentary tunicate) 167753 Capitella spl (polychaete worm) DDB0220640 Dictyostelium discoideum (amoeba) DEHA2G12496g Debaryomyces Hansenii (yeast) 227473 Daphnia pulex (daphnia) ENSDARP00000080170 Danio rerio (zebra fish) ENSECAP00000021298 Equus caballus (horse) XP_654639 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000017517 Gymnopilus aculeatus (mushroom) ENSGALP00000011246 Gallus gallus (chicken) 192382 Hypsipyla robusta (cedar shoot borer) ENSP00000377747 Homo sapiens (human) ISCW004121-PA Ixodes scapularis (deer tick) KLLA0C17578g Kluyveromyces lactis (yeast) 218699 Lottia gigantea (owl limpet) LmjF25.2050 Leishmania major (virus) ENSMODP00000016479 Monodelphis domestica (gray opossum) ENSMMUP00000018527 Macaca mulatta (rhesus monkey) ENSMUSP00000024627 Mus musculus (house mouse) 50041 Nematostella vectensis (starlet anemone) ENSOANP00000006945 Ornithorynchus anatinus (platypus) ENSORLP00000010555 Oryzias latipes (japanese killifish) PHUM000821-PA Pediculus humanus (human body louse) 132084 Physcomitrella patens (moss) ENSPPYP00000017508 Pongo pygmaeus (orangutan) 74211 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000012779 Pan troglodytes (chimpanzee) PVX_111520 Plasmodium vivax (protozoal parasite) ENSRNOP00000017144 Rattus norvegicus (norway rat) 5052190 Sorghum bicolor (sorghum) YER164W Saccharomyces cerevisiae (budding yeast) Smp_041760 Schistosoma mansoni (trematode parasite) SPAC3G6.01 Schizosaccharomyces pombe (fission yeast) XP_001181304.1 Strongylocentrotus purpuratus (purple sea urchin) 54568 Trichoplax adhaerens (metazoa) TA06105 Theileria annulata (apicomplexan parasite) XP_970343.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013680 Tetraodon nigroviridis (green spotted pufferfish) TP01_0866 Theileria parva (parasitic protozoan) ENSTRUP00000022210 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000025881 Takifugu rubripes (pufferfish Takifugu) 16.m00319 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000052094 Xenopus tropicalis (frog) YALI0C00363g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/chd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33505 modMine - Data generated by the modENCODE project. • FBgn0250786 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10806 NV11865 LH16490 ISCW004121 FBgn0232558 FBgn0217579 FBgn0205442 FBgn0194180 FBgn0173086 JGI_V11_227473 FBgn0077660 FBgn0164283 FBgn0133534 FBgn0118124 FBgn0116602 FBgn0091364 CPIJ001937 BGIBMGA003497 ACYPI003241 GB14981 AGAP008698 AAEL004716 PHUM370270 GLEAN_10805
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG3733 (Spellman and Rubin, 2002, Konev et al., 2007, Keleman et al., 2009.8.5, Schneiderman et al., 2009, Schneiderman et al., 2010, Ni et al., 2010.12.1, Ni et al., 2011.7.19) chd1 (Levine and Begun, 2008, McDaniel et al., 2008, Lasko, 2000, Armstrong et al., 2007, McDaniel, 2006.10.11, Armstrong et al., 2008) Chd1 (Spellman and Rubin, 2002, Morettini et al., 2011, Konev et al., 2007, Mendjan et al., 2006, Vázquez et al., 2008, Petesch and Lis, 2008, Doheny et al., 2008, Schneiderman et al., 2009, Eissenberg et al., 2007, Podhraski et al., 2010, Schneiderman et al., 2010, Wasbrough et al., 2010) CHD1 (Eissenberg et al., 2007, Polo, 2006, Brehm et al., 2004, Konev et al., 2007, Podhraski et al., 2010, Lusser et al., 2005) CHD-1 (Khattak et al., 2002, Eissenberg, 2001, Stokes, 1996.8.13, Tsukiyama and Wu, 1997, ) dCHD1 (Kelley et al., 1999, Stokes et al., 1996) DmCHD1 (Woodage et al., 1997) l(2)23Cd
Name Synonym	chromo-ATPase/helicase-DNA-binding domain (Stokes et al., 1996) chromo-ATPase/helicase-DNA-binding protein 1 (Lusser et al., 2005) Chromodomain-helicase-DNA-binding protein   Chromodomain-helicase-DNA-binding protein 1   lethal (2) 23Cd
Secondary FlyBase IDs
	FBgn0016132 FBgn0040118
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Morettini et al., 2011, Nucleic Acids Res. 39(8): 3103--3115 The chromodomains of CHD1 are critical for enzymatic activity but less important for chromatin localization. [FBrf0213515] Podhraski et al., 2010, PLoS ONE 5(4): e10120 CenH3/CID incorporation is not dependent on the chromatin assembly factor CHD1 in Drosophila. [FBrf0210586] Schneiderman et al., 2010, PLoS Genet. 6(9): e1001095 Perturbation Analysis of Heterochromatin-Mediated Gene Silencing and Somatic Inheritance. [FBrf0211786] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...