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Gene Dmel\Snap

General Information
Symbol	Dmel\Snap	Species	D. melanogaster
Name	Soluble NSF attachment protein	Annotation symbol	CG6625
Feature type	protein_coding_gene	FlyBase ID	FBgn0250791
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dSNAP, α-SNAP
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	77B3-77B9	Sequence location	3L:20,306,734..20,309,677 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Soluble NSF attachment protein is referred to in FlyBase by the symbol Dmel\Snap (CG6625, FBgn0250791). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: soluble NSF attachment protein activity. There is experimental evidence that it is involved in the biological process: synaptic transmission; imaginal disc-derived wing expansion; cytokinesis; compound eye morphogenesis; phagocytosis, engulfment. 18 alleles are reported. The phenotypes of these alleles are annotated with: tracheal branch primordium; embryonic/first instar larval cuticle; eye; bouton; embryonic/larval neuromuscular junction; wing; Golgi apparatus. It has one annotated transcript and one annotated polypeptide. Protein features are: NSF attachment protein; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632291_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Snap. Gene sequence location is 3L:20306734..20309677.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27928 BKN27910 HFA11285
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77B3-77B9   Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103; Left limit from inclusion within Df(3L)th2 (FBrf0123112) Right limit from non-inclusion within Df(3L)st62 (FBrf0123112)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 77B-77B   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000) 77B1-77B4     (Ordway, 1994.5.4)
Experimentally Determined Recombination Data
Location	3- (Ordway, 1994.5.4)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Snap for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Snap-RA FBtr0074840  NM_079456   2068   292
Additional Transcript Data & Comments
Reported size (kB)	2.3, 1.9, 1.5 (northern blot) (Ordway et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Snap-PA   FBpp0074609   33.0   292   5.12     NP_524180   AAF49035
Additional Polypeptide Data & Comments
Reported size (kDa)	292 (aa) (Ordway et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NSF attachment protein (IPR000744) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201929   AA392604   AA441680   AA536479   AA695107   AA735597   AE014296 AAF49035   AI061963   AI108951   AI135382   AI135584   AI260194   AI260575   AI293764   AI297504   AI455172   AI516993   AI518024   AI518641   AI519682   AI947007   AX093947   AY069477 AAL39622   BF490731   BF500004   BG632717   BG636250   BG639198   BI171072   BI172366   BI173667   BI214468   BI228803   BI228889   BI229575   BI231439   BI240019   BI358521   BI361550   BI362585   BI364596   BI367277   BI367330   BI367449   BI369400   BI481947   BI486554   BI486600   BI564631   BI574658   BI574762   BI578175   BI578244   BI578338   BI578421   BI579202   BI579768   BI579835   BI605002   BI605903   BI619235   BI622501   BI626324   BI633872   BP546869   BP553130   CA804968   CK657193   CL527958   CO179569   CO183020   CO195077   CO269881   CO272325   CO280349   CO284410   CO293748   CO300006   CO301555   CO310944   CO314107   CO331381   CZ487336   CZ487337   EC069961   EC071822   EC088369   EC201324   EC202825   EC213492   EC220083   EC222216   EC224028   EC228048   EC234232   EC235499   EC243148   EV595635   GH754534   GH755319   GH759776   GH781225   GH782084   GH785555   GH791942   GH794296   GH795679   GH799584   GH801653   GH804674   GH808691   GH810968   GH823426   GH823918   GH838508   GH840299   GH844556   GH844975   GH855874   GH858152   GH861222   GH862410   GH865121   GH867160   GH870352   GH871722   GH873120   GH874013   GH874413   GH880390   GH881571   GH884202   GH888081   GH898873   GH902541   GH904775   GH907224   GH908920   GH911677   GH914207   GH914516   GH914588   GH914716   GH919365   GH922545   GH923636   GH926198   GH926894   GH927611   GH931275   GH932968   GH936214   GH937073   GH937244   GH938511   U09374 AAA83414
UniProtKB/Swiss-Prot	Q23983
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   presumptive embryonic/larval central nervous system   (Ordway et al., 1994) larval stage     (Ordway et al., 1994) adult stage     (Ordway et al., 1994)
Additional Descriptive Data
	Snap transcripts are detected in RNA from larvae and adults on northern blots. In situ hybridization in embryos shows expression in the CNS. (Ordway et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0250791    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0250791 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0250791 expression level Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3410) embryo 02-04hr  (4650) embryo 04-06hr  (3999) embryo 06-08hr  (4003) embryo 08-10hr  (4802) embryo 10-12hr  (5759) embryo 12-14hr  (4499) embryo 14-16hr  (4636) embryo 16-18hr  (6100) embryo 18-20hr  (5324) embryo 20-22hr  (4994) embryo 22-24hr  (5635) larva L1  (3645) larva L2  (3293) larva L3 12hr old  (2377) larva L3 puffstage 1-2  (3070) larva L3 puffstage 3-6  (4271) larva L3 puffstage 7-9  (7093) white prepupae new  (9236) white prepupae 12hr  (7443) white prepupae 24hr  (5104) pupae 2d postWPP  (6186) pupae 3d postWPP  (5030) pupae 4d postWPP  (3327) adult male 01day  (4354) adult male 05day  (4416) adult male 30day  (4098) adult female 01day  (3449) adult female 05day  (3570) adult female 30day  (3643) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3410) embryo 02-04hr  (4650) embryo 04-06hr  (3999) embryo 06-08hr  (4003) embryo 08-10hr  (4802) embryo 10-12hr  (5759) embryo 12-14hr  (4499) embryo 14-16hr  (4636) embryo 16-18hr  (6100) embryo 18-20hr  (5324) embryo 20-22hr  (4994) embryo 22-24hr  (5635) larva L1  (3645) larva L2  (3293) larva L3 12hr old  (2377) larva L3 puffstage 1-2  (3070) larva L3 puffstage 3-6  (4271) larva L3 puffstage 7-9  (7093) white prepupae new  (9236) white prepupae 12hr  (7443) white prepupae 24hr  (5104) pupae 2d postWPP  (6186) pupae 3d postWPP  (5030) pupae 4d postWPP  (3327) adult male 01day  (4354) adult male 05day  (4416) adult male 30day  (4098) adult female 01day  (3449) adult female 05day  (3570) adult female 30day  (3643) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0250791 expression level Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3410) embryo 02-04hr  (4650) embryo 04-06hr  (3999) embryo 06-08hr  (4003) embryo 08-10hr  (4802) embryo 10-12hr  (5759) embryo 12-14hr  (4499) embryo 14-16hr  (4636) embryo 16-18hr  (6100) embryo 18-20hr  (5324) embryo 20-22hr  (4994) embryo 22-24hr  (5635) larva L1  (3645) larva L2  (3293) larva L3 12hr old  (2377) larva L3 puffstage 1-2  (3070) larva L3 puffstage 3-6  (4271) larva L3 puffstage 7-9  (7093) white prepupae new  (9236) white prepupae 12hr  (7443) white prepupae 24hr  (5104) pupae 2d postWPP  (6186) pupae 3d postWPP  (5030) pupae 4d postWPP  (3327) adult male 01day  (4354) adult male 05day  (4416) adult male 30day  (4098) adult female 01day  (3449) adult female 05day  (3570) adult female 30day  (3643) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3410) embryo 02-04hr  (4650) embryo 04-06hr  (3999) embryo 06-08hr  (4003) embryo 08-10hr  (4802) embryo 10-12hr  (5759) embryo 12-14hr  (4499) embryo 14-16hr  (4636) embryo 16-18hr  (6100) embryo 18-20hr  (5324) embryo 20-22hr  (4994) embryo 22-24hr  (5635) larva L1  (3645) larva L2  (3293) larva L3 12hr old  2377 larva L3 puffstage 1-2  (3070) larva L3 puffstage 3-6  (4271) larva L3 puffstage 7-9  (7093) white prepupae new  (9236) white prepupae 12hr  (7443) white prepupae 24hr  (5104) pupae 2d postWPP  (6186) pupae 3d postWPP  (5030) pupae 4d postWPP  (3327) adult male 01day  (4354) adult male 05day  (4416) adult male 30day  (4098) adult female 01day  (3449) adult female 05day  (3570) adult female 30day  (3643) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3410 embryo 02-04hr    4650 embryo 04-06hr    3999 embryo 06-08hr    4003 embryo 08-10hr    4802 embryo 10-12hr    5759 embryo 12-14hr    4499 embryo 14-16hr    4636 embryo 16-18hr    6100 embryo 18-20hr    5324 embryo 20-22hr    4994 embryo 22-24hr    5635 larva L1    3645 larva L2    3293 larva L3 12hr old    2377 larva L3 puffstage 1-2    3070 larva L3 puffstage 3-6    4271 larva L3 puffstage 7-9    7093 white prepupae new    9236 white prepupae 12hr    7443 white prepupae 24hr    5104 pupae 2d postWPP    6186 pupae 3d postWPP    5030 pupae 4d postWPP    3327 adult male 01day    4354 adult male 05day    4416 adult male 30day    4098 adult female 01day    3449 adult female 05day    3570 adult female 30day    3643 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0250791    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0250791 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0250791 expression level Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain    2057.5 Adult Thoracic-Abdominal Ganglion    2365.9 Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (644.2) Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head  (954) Adult Eye  (648.025) Adult Brain  (2057.5) Adult Thoracic-Abdominal Ganglion  (2365.9) Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain  (2057.5) Adult Thoracic-Abdominal Ganglion  (2365.9) Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain    2057.5 Adult Thoracic-Abdominal Ganglion    2365.9 Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0250791 expression level Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain    2057.5 Adult Thoracic-Abdominal Ganglion    2365.9 Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head  (954) Adult Eye  648.025 Adult Brain  (2057.5) Adult Thoracic-Abdominal Ganglion  (2365.9) Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain  (2057.5) Adult Thoracic-Abdominal Ganglion  (2365.9) Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    80.7 Larval Hindgut    120.2 Larval Malpighian Tubules    222.8 Larval Fat Body    150.4 Larval Salivary Gland    105.1 Larval Trachea    73.275 Larval Carcass    92.175 Adult Head    954 Adult Eye    648.025 Adult Brain    2057.5 Adult Thoracic-Abdominal Ganglion    2365.9 Adult Crop    206.1 Adult Midgut    79.6 Adult Hindgut    152.8 Adult Malpighian Tubules    192.2 Adult Fat Body    85.9 Adult Salivary Gland    91.6 Adult Heart    131.4 Adult VirginFemale Spermatheca    196.4 Adult InseminatedFemale Spermatheca    171.1 Adult Ovary    36.1 Adult Testis    19.9 Adult Male Accessory Gland    167.1 Adult Carcass    138.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    954   NA  Eye    648.025   NA  Brain    2057.5   644.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2365.9   NA  Crop    206.1   80.7  Midgut    79.6   120.2  Hindgut    152.8   222.8  Malpighian Tubules    192.2   150.4  Fat Body    85.9   105.1  Salivary Gland    91.6   NA  Heart    131.4   73.275  Trachea    NA   NA  VirginFemale Spermatheca    196.4   NA  InseminatedFemale Spermatheca    171.1   NA  Ovary    36.1   NA  Testis    19.9   NA  Male Accessory Gland    167.1   92.175  Carcass    138.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250791 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Snap Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav-C155 SnapScer\UAS.cPa lethal, with Scer\GAL4Mef2.PR SnapGD11986 lethal, with Scer\GAL4pnr-MD237 SnapGD11986 lethal (with Df(3L)rdgC-co2) Snapl65 lethal | embryonic stage (with Df(3L)rdgC-co2) SnapM3 lethal | embryonic stage | recessive SnapI1 Snapl65 SnapM3 lethal | first instar larval stage | recessive SnapG8 lethal | larval stage | recessive SnapP2 lethal | recessive SnapG8 SnapI1 SnapM3 SnapM4 SnapO1 SnapP2 SnapY7 semi-lethal, with Scer\GAL4elav.PLu SnapGD11986 semi-lethal (with Df(3L)rdgC-co2) SnapM4 viable SnapEY06922 SnapM4 Sterility Allele fertile SnapEY06922 Other Phenotypes Allele flight defective, with Scer\GAL4elav.PLu SnapGD11986 locomotor behavior defective, with Scer\GAL4elav.PLu SnapGD11986 neurophysiology defective, with Scer\GAL4OK6 SnapScer\UAS.cPa neurophysiology defective (with Df(3L)rdgC-co2) SnapM4 uncoordinated (with Df(3L)rdgC-co2) SnapM4 Phenotype manifest in Allele bouton, with Scer\GAL4OK6 SnapScer\UAS.cPa embryonic/first instar larval cuticle (with Df(3L)rdgC-co2) SnapM3 embryonic/larval neuromuscular junction, with Scer\GAL4OK6 SnapScer\UAS.cPa eye, with Scer\GAL4GMR.PF SnapScer\UAS.cPa Golgi apparatus, with Scer\GAL4hs.PB SnapScer\UAS.cPa Golgi stack | ectopic, with Scer\GAL4hs.PB SnapScer\UAS.cPa tracheal branch primordium (with Df(3L)rdgC-co2) SnapM3 wing, with Scer\GAL4elav-C155 SnapScer\UAS.cPa
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Snap Class Mutagen Stocks Known lesion SnapEY06922 P-element activity 1 -- Snapf04776 piggyBac transposase 1 -- SnapG8 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes SnapGS21416 1 -- SnapM4 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes SnapI1 loss of function allele ethyl methanesulfonate 0 Yes Snapl65 loss of function allele ethyl methanesulfonate 0 Yes SnapM3 loss of function allele ethyl methanesulfonate 0 Yes SnapO1 ethyl methanesulfonate 0 Yes SnapP2 ethyl methanesulfonate 0 Yes SnapY7 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Snap Class Mutagen Stocks Known lesion SnapGD11986 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SnapHMS00872 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SnapJF03266 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SnapKK107910 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Snap+t8.9 in vitro construct - genomic fragment 0 Yes SnapKK107928 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SnapScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6136 (Ryder, 2004.4.26) Df(3L)rdgC-co2 (Lukinova et al., 1999)
Not disrupted in	Df(3L)ri-79c (Lukinova et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11986} NA P{KK107910} NA P{KK107928} NA P{TRiP.HMS00872} NA P{TRiP.JF03266} NA P{UAS-Snap.P} NA characterization construct P{Snap8.9+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}SnapEY06922 NA P{GSV7}SnapGS21416 NA miscellaneous insertions P{wHy}poloDG12705 NA PBac{WH}Snapf04776 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Babcock et al., 2004) cytokinesis inferred from mutant phenotype (Echard et al., 2004) imaginal disc-derived wing expansion inferred from mutant phenotype (Babcock et al., 2004) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) synaptic transmission inferred from mutant phenotype (Babcock et al., 2004)
Cellular Component
CV term Evidence References
axon terminus inferred from direct assay (Babcock et al., 2004)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-) soluble NSF attachment protein activity non-traceable author statement (Ordway, 1994.5.4, Lloyd et al., 2000)
Biological Process
CV term Evidence References
ER to Golgi vesicle-mediated transport non-traceable author statement (Swiss-Prot Project Members, 2001.10.16) intracellular protein transport inferred from electronic annotation with InterPro:IPR000744 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic vesicle priming non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
extrinsic to membrane non-traceable author statement (Swiss-Prot Project Members, 2001.10.16)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Snap allele Gene References unspecified comt (Babcock et al., 2004) Nsf2 (Babcock et al., 2004, Laviolette et al., 2005) Syx1A (Babcock et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250791 DroID - A comprehensive database of gene and protein interactions. • FBgn0250791 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40233
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10051 Dere\GG16100 Dgri\GH14381 Dmoj\GI11324 Dper\GL25130 Dpse\GA19734 Dsec\GM22271 Dsim\GD14872 Dvir\GJ11580 Dwil\GK16949 Dyak\GE19660
Curated drosophilid orthologs	Dpse\GA19734
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011776-PA Aedes aegypti (mosquito) AGAP003192-PA Anopheles gambiae (mosquito) XP_625208.1 Apis mellifera (honey bee) XP_001949170.1 Acyrthosiphon pisum (pea aphid) At3g56190.1 Arabidopsis thaliana (wall cress) 18818 Batrachochytrium dendrobatidis (chytrid fungus) 114106 Branchiostoma floridae (lancelet) BGIBMGA010068-PA Bombyx mori (silk worm) ENSBTAP00000005402 Bos taurus (bovine) ENSBTAP00000017397 Bos taurus (bovine) CAL0002396 Candida albicans (a form of yeast) CN01009 Caenorhabditis brenneri (small nematode) CBP33051 Caenorhabditis briggsae (nematode) CE38494 Caenorhabditis elegans (worm) ENSCAFP00000007655 Canis familiaris (dog) CAGL0F04653g Candida glabrata (haploid yeast) Chro.20087 Cryptosporidium hominis (obligate parasite) CMP229C Cyanidioschyzon merolae (red alga) cn08140 Cryptococcus neoformans (yeast-like fungus) cgd2_760 Cryptosporidium parvum (protozoan parasite) CPIJ013203 Culex pipens (mosquito) ENSCPOP00000009533 Cavia porcellus (guinea pig) 23974 Chlamidomonas reinhardtii (green alga) RP40520 Caenorhabditis remanei (nematode) ENSCSAVP00000006536 Ciona savignyi (sedentary tunicate) 226902 Capitella spl (polychaete worm) DDB0231538 Dictyostelium discoideum (amoeba) DEHA2C05368g Debaryomyces Hansenii (yeast) 188735 Daphnia pulex (daphnia) ENSDARP00000009285 Danio rerio (zebra fish) ENSECAP00000005451 Equus caballus (horse) XP_651192 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000017204 Gymnopilus aculeatus (mushroom) ENSGALP00000013516 Gallus gallus (chicken) GL50803_17224 Giardia lamblia (flagellated protozoan) 157419 Hypsipyla robusta (cedar shoot borer) ENSP00000263354 Homo sapiens (human) ISCW015531-PA Ixodes scapularis (deer tick) KLLA0E05919g Kluyveromyces lactis (yeast) 205108 Lottia gigantea (owl limpet) LmjF20.1690 Leishmania major (virus) 19147 Monocosta brevicollis (choanoflagellate) ENSMODP00000010976 Monodelphis domestica (gray opossum) ENSMMUP00000031552 Macaca mulatta (rhesus monkey) ENSMUSP00000006181 Mus musculus (house mouse) 174745 Nematostella vectensis (starlet anemone) XP_001599153.1 Nasonia vitripennis (wasp) ENSOANP00000000433 Ornithorynchus anatinus (platypus) ENSORLP00000012536 Oryzias latipes (japanese killifish) LOC_Os08g18110.1 Oryza sativa (asian rice) 23126 Ostreococcus tauri (green alga) PFE0445c Plasmodium falciparum (protozoal parasite) PHUM011377-PA Pediculus humanus (human body louse) PP04053 Pristionchus pacificus (nematode) 55046 Physcomitrella patens (moss) ENSPPYP00000012031 Pongo pygmaeus (orangutan) 78325 Phytophthora ramorum (sudden oak death pathogen) 133598 Phytophthora sojae (root rot pathogen) 724356 Populus trichocarpa (black cottonwood) ENSPTRP00000043338 Pan troglodytes (chimpanzee) PVX_098015 Plasmodium vivax (protozoal parasite) ENSRNOP00000002044 Rattus norvegicus (norway rat) 5058673 Sorghum bicolor (sorghum) YBL050W Saccharomyces cerevisiae (budding yeast) Smp_060950 Schistosoma mansoni (trematode parasite) SPAC959.02 Schizosaccharomyces pombe (fission yeast) XP_785670.1 Strongylocentrotus purpuratus (purple sea urchin) 32131 Trichoplax adhaerens (metazoa) TA15375 Theileria annulata (apicomplexan parasite) XP_973149.1 Tribolium castaneum (red flour beetle) Tc00.1047053506363.150 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508405.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002891 Tetraodon nigroviridis (green spotted pufferfish) TP02_0828 Theileria parva (parasitic protozoan) 269412 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017349 Takifugu rubripes (pufferfish Takifugu) 86.m00170 Tetrahymena thermophila (ciliate protozoa) 86233.m00026 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006070 Xenopus tropicalis (frog) YALI0C23947g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18645 LH11648 ISCW015531 FBgn0237000 FBgn0236997 FBgn0218948 FBgn0198838 FBgn0186545 FBgn0177141 JGI_V11_188735 JGI_V11_56960 FBgn0079730 FBgn0162717 FBgn0134085 FBgn0121857 FBgn0108335 FBgn0087092 CPIJ013203 BGIBMGA010068 ACYPI001188 GB15709 AGAP003192 AAEL011776 PB19767 PHUM600830 GLEAN_13571
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	5465 SnapM4/TM6C, Sb1 5467 SnapG8/TM6C, Sb1 29587 y1 v1; P{TRiP.JF03266}attP2 16770 y1 w67c23; P{EPgy2}SnapEY06922 34088 y1 sc* v1; P{TRiP.HMS00872}attP2
Harvard	- PBac{WH}Snapf04776
Kyoto	202737 y1 w67c23; P{GSV7}SnapGS21416/TM3, Sb1 Ser1
VDRC	v101341 P{KK107910}VIE-260B v22379 w1118; P{GD11986}v22379
Genomic Clones ( 1 )
	BACR16G09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 149 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21601
Other clones	DPiM_LD21601
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14791 AT27291 GH07436 GH12751 GH13084 GH13394 GH27613 GM02149 LD04078 LD12845 LD16687 LD17109 LD35071 LD37424 LD38263 LD39350 LD46881 LP03904 LP04493 LP06976 LP11815 LP23292 RE12744 RE14822 RE16731 RE20285 RE21909 RE26447 RE26547 RE27382 RE36661 RE45304 RE45813 RE47184 RE49753 RE53013 RE53072 RE53219 RE55570 RE64577 RE70002 RE70050 RE72006 RE72088 RE72201 RE72289 RE73192 RE73848 RE73924 RH25968 RH26589 RH50225 RH54384 RH61956 RH67007 RH70514 RH71914 SD13874 SD28048
Other clones	8337 39896 50907 70811 70912 74520 100217 108564 118418 272661 bs34a04 CK01.76C.B4 CK01.125C.F11 CK01.125D.C5 Dmel_neb_002683_0698_0307 EC24427 EC39673 EK059829 EK096224 EK106740 EK153833 EK166008 EK177217 EK181407 EK204448 EK223026 EK235118 EK299441 ESG0115d.B21_H09 FGH111A03 FGM222F12 RP003007367 RP003060370 RP003063654 RP003086227 RP003095171 RP003103363 RP003115700 RP003122134 RP003142342 RP003165838 RP003186205 RP003212822 RP003217324 RP003219620 RP003223261 RP003224154 RP003226891 RP003229457 RP003263520 RP003265065 RP003269951 RP003272137 RP003280841 RP003286569 RP003298269 RP003304270 RP003304783 RP003309692 RP003312798 RP003314841 RP003326492 RP003333205 RP003337619 RP003347055 RP003385352 RP003396446 RP003411268 RP003412554 RP003439582 RP003480628 RP003484038 RP003488550 RP003500500 RP003501649 RP003525086 RP003532908 RP003535787 RP003541105 RP003549835 RP003557843 RP003563804 RP003564674 RP003580590 RP003580603 RP003585749 RP003626169 RP003663349
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0250791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40233 250431 250432
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Snap l(3)77ABc l(3)77ABa (Babcock et al., 2004)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) Snap is required for the terminal (post-furrowing) events of cytokinesis. (Echard et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila SNAP gene, Acc. No. U09374. (Davies, 2001.3.15) Snap gene has been cloned and the gene product characterised. (Ordway et al., 1994) The neurosecretory apparatus of the presynaptic nerve terminal contains a core complex of conserved secretory proteins, Snap is a component this complex. (Pallanck et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079456 RefSeq (Proteins) • NP_524180 DDBJ / EMBL / GenBank • AA695107 AA735597 AAA83414 AAF49035 AAL39622 AI260575 AI455172 AI947007 AX093947 AY069477 CL527958 CZ487336 CZ487337 U09374 Entrez Gene - A searchable database of RefSeq genes. • 40233 UniProtKB/Swiss-Prot • Q23983
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NSF attachment protein (IPR000744) Tetratricopeptide-like helical (IPR011990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0250791 DroID - A comprehensive database of gene and protein interactions. • FBgn0250791 DRSC - Results from RNAi screens. • FBgn0250791 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250791 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0250791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40233 250431 250432 InParanoid A subset of ortholog calls from InParanoid. • AAEL011776-PA Aedes aegypti (mosquito) AGAP003192-PA Anopheles gambiae (mosquito) XP_625208.1 Apis mellifera (honey bee) XP_001949170.1 Acyrthosiphon pisum (pea aphid) At3g56190.1 Arabidopsis thaliana (wall cress) 18818 Batrachochytrium dendrobatidis (chytrid fungus) 114106 Branchiostoma floridae (lancelet) BGIBMGA010068-PA Bombyx mori (silk worm) ENSBTAP00000005402 Bos taurus (bovine) ENSBTAP00000017397 Bos taurus (bovine) CAL0002396 Candida albicans (a form of yeast) CN01009 Caenorhabditis brenneri (small nematode) CBP33051 Caenorhabditis briggsae (nematode) CE38494 Caenorhabditis elegans (worm) ENSCAFP00000007655 Canis familiaris (dog) CAGL0F04653g Candida glabrata (haploid yeast) Chro.20087 Cryptosporidium hominis (obligate parasite) CMP229C Cyanidioschyzon merolae (red alga) cn08140 Cryptococcus neoformans (yeast-like fungus) cgd2_760 Cryptosporidium parvum (protozoan parasite) CPIJ013203 Culex pipens (mosquito) ENSCPOP00000009533 Cavia porcellus (guinea pig) 23974 Chlamidomonas reinhardtii (green alga) RP40520 Caenorhabditis remanei (nematode) ENSCSAVP00000006536 Ciona savignyi (sedentary tunicate) 226902 Capitella spl (polychaete worm) DDB0231538 Dictyostelium discoideum (amoeba) DEHA2C05368g Debaryomyces Hansenii (yeast) 188735 Daphnia pulex (daphnia) ENSDARP00000009285 Danio rerio (zebra fish) ENSECAP00000005451 Equus caballus (horse) XP_651192 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000017204 Gymnopilus aculeatus (mushroom) ENSGALP00000013516 Gallus gallus (chicken) GL50803_17224 Giardia lamblia (flagellated protozoan) 157419 Hypsipyla robusta (cedar shoot borer) ENSP00000263354 Homo sapiens (human) ISCW015531-PA Ixodes scapularis (deer tick) KLLA0E05919g Kluyveromyces lactis (yeast) 205108 Lottia gigantea (owl limpet) LmjF20.1690 Leishmania major (virus) 19147 Monocosta brevicollis (choanoflagellate) ENSMODP00000010976 Monodelphis domestica (gray opossum) ENSMMUP00000031552 Macaca mulatta (rhesus monkey) ENSMUSP00000006181 Mus musculus (house mouse) 174745 Nematostella vectensis (starlet anemone) XP_001599153.1 Nasonia vitripennis (wasp) ENSOANP00000000433 Ornithorynchus anatinus (platypus) ENSORLP00000012536 Oryzias latipes (japanese killifish) LOC_Os08g18110.1 Oryza sativa (asian rice) 23126 Ostreococcus tauri (green alga) PFE0445c Plasmodium falciparum (protozoal parasite) PHUM011377-PA Pediculus humanus (human body louse) PP04053 Pristionchus pacificus (nematode) 55046 Physcomitrella patens (moss) ENSPPYP00000012031 Pongo pygmaeus (orangutan) 78325 Phytophthora ramorum (sudden oak death pathogen) 133598 Phytophthora sojae (root rot pathogen) 724356 Populus trichocarpa (black cottonwood) ENSPTRP00000043338 Pan troglodytes (chimpanzee) PVX_098015 Plasmodium vivax (protozoal parasite) ENSRNOP00000002044 Rattus norvegicus (norway rat) 5058673 Sorghum bicolor (sorghum) YBL050W Saccharomyces cerevisiae (budding yeast) Smp_060950 Schistosoma mansoni (trematode parasite) SPAC959.02 Schizosaccharomyces pombe (fission yeast) XP_785670.1 Strongylocentrotus purpuratus (purple sea urchin) 32131 Trichoplax adhaerens (metazoa) TA15375 Theileria annulata (apicomplexan parasite) XP_973149.1 Tribolium castaneum (red flour beetle) Tc00.1047053506363.150 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508405.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002891 Tetraodon nigroviridis (green spotted pufferfish) TP02_0828 Theileria parva (parasitic protozoan) 269412 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017349 Takifugu rubripes (pufferfish Takifugu) 86.m00170 Tetrahymena thermophila (ciliate protozoa) 86233.m00026 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006070 Xenopus tropicalis (frog) YALI0C23947g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40233 modMine - Data generated by the modENCODE project. • FBgn0250791 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18645 LH11648 ISCW015531 FBgn0237000 FBgn0236997 FBgn0218948 FBgn0198838 FBgn0186545 FBgn0177141 JGI_V11_188735 JGI_V11_56960 FBgn0079730 FBgn0162717 FBgn0134085 FBgn0121857 FBgn0108335 FBgn0087092 CPIJ013203 BGIBMGA010068 ACYPI001188 GB15709 AGAP003192 AAEL011776 PB19767 PHUM600830 GLEAN_13571
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	alpha-SNAP (Dunne and Rabouille, 2001) CG6625 (Verstreken and Bellen, 2000.9.4, Nybakken et al., 2005, Keleman et al., 2009.8.5, Gandhi et al., 2007, Perkins et al., 2009, Ni et al., 2010.12.1, Cammarato et al., 2011) dSNAP (Xu et al., 2002, Dunne et al., 2002, Pallanck et al., 1994) dsnap (Dunne et al., 2002, Schotman et al., 2008) dα-SNAP (Xu et al., 2002) dαSNAP (Bate and Broadie, 1995) l(3)77ABa   l(3)77ABc   SNAP (Ohyama et al., 2007, Babcock et al., 2004, Lloyd et al., 2000, Kaltenbach et al., 2007, Sepp et al., 2008, Simons et al., 2009) Snap (Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Nybakken et al., 2005, Baeg et al., 2007, Dietzl et al., 2007, Romero et al., 2008, Dierick and Greenspan, 2006, Betz and Darnell, 2006, Zhou et al., 2008) snap (Laviolette et al., 2005, Beckstead et al., 2007) α-SNAP (Echard et al., 2004, Muller et al., 2002, Weidenhaupt et al., 2000) αSnap (Littleton et al., 1998)
Name Synonym	lethal (3) 77ABa   lethal (3) 77ABc   soluble N-ethylmaleimide-sensitive factor attachment protein (Kaltenbach et al., 2007) soluble NSF attachment protein (Ordway, 1994.5.4) Soluble NSF attachment protein (Cammarato et al., 2011) soluble NSF-attachment protein (Romero et al., 2008)
Secondary FlyBase IDs
	FBgn0011712 FBgn0029028 FBgn0029029
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 7 ) Review  ( 3 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 1 )
	Yu et al., 2011, Mol. Cell. Neurosci. 47(1): 19--27 Activity-dependent interactions of NSF and SNAP at living synapses. [FBrf0213595] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...