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Gene Dmel\gish

General Information
Symbol	Dmel\gish	Species	D. melanogaster
Name	gilgamesh	Annotation symbol	CG6963
Feature type	protein_coding_gene	FlyBase ID	FBgn0250823
Gene Model Status	Current	Stock availability	30 publicly available
Also Known As	ms(3)89B, CKIγ, Hrr25
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89B9-89B12	Sequence location	3R:12,098,176..12,128,443 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene gilgamesh is referred to in FlyBase by the symbol Dmel\gish (CG6963, FBgn0250823). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: olfactory learning; glial cell migration; protein phosphorylation; Wnt receptor signaling pathway; spermatogenesis. 55 alleles are reported. The phenotypes of these alleles are annotated with: spermatogonium; eye; trichogen cell; photoreceptor cell; ommatidium. It has 11 annotated transcripts and 11 annotated polypeptides. Protein features are: Casein kinase 1 gamma C-terminal; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626805_s_at completely aligns to an exonic region of only a subset of 8 of the 9 FlyBase-annotated transcript isoforms of gish. Gene sequence location is 3R:12098176..12128443.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms dendrite ellipsoid body mushroom body gamma-lobe mushroom body beta'-lobe mushroom body beta-lobe adult pedunculus dendrite adult mushroom body mushroom body alpha-lobe axon adult central complex mushroom body alpha'-lobe protocerebral bridge axon calyx of adult mushroom body nodulus fan-shaped body adult head References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features HFA16154 BKN51216 BKN51007 BKN28680
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B9-89B12   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B1-89B22   (determined by in situ hybridisation)   (Spradling et al., 1999) 89B1-89B22     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\gish for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) gish-RA FBtr0083263  NM_169711   2658   422 gish-RB FBtr0083262  NM_169712   3221   468 gish-RC FBtr0083264  NM_080202   2324   427 gish-RD FBtr0083261  NM_169713   2943   468 gish-RE FBtr0083265  NM_176506   3206   463 gish-RF FBtr0100331  NM_001014628   2135   358 gish-RG FBtr0100332  NM_001014627   1959   476 gish-RH FBtr0100333  NM_001014626   3143   468 gish-RI FBtr0301304  NM_001170157   3205   474 gish-RJ FBtr0305071     3346   521 gish-RK FBtr0305072     3271   496
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein gish-PA   FBpp0082717   48.2   422   9.27     NP_732123   AAF55293 gish-PB   FBpp0082716   52.6   468   9.78     NP_732124   AAF55294 gish-PC   FBpp0082718   48.7   427   9.57     NP_524941   AAN13703 gish-PD   FBpp0082715   52.6   468   9.78     NP_732125   AAN13704 gish-PE   FBpp0082719   52.1   463   9.55     NP_788683   AAO41569 gish-PF   FBpp0099736   40.9   358   9.68     NP_001014628   AAX52957 gish-PG   FBpp0099737   53.6   476   9.72     NP_001014627   AAX52958 gish-PH   FBpp0099738   52.6   468   9.78     NP_001014626   AAX52956 gish-PI   FBpp0290519   53.3   474   9.76     NP_001163628   ACZ94924 gish-PJ   FBpp0293608   58.4   521   8.94       gish-PK   FBpp0293609   55.5   496   9.83
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Casein kinase 1 gamma C-terminal (IPR022247)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201386   AA264321   AA264396   AA390548   AA391262   AA540797   AA695782   AA696055   AA801759   AA816247   AA821244   AA949351   AA949934   AA950661   AA950799   AA950985   AE014297 AAF55293   AE014297 AAF55294   AE014297 AAN13703   AE014297 AAN13704   AE014297 AAO41569   AE014297 AAX52956   AE014297 AAX52957   AE014297 AAX52958   AE014297 ACZ94924   AI257116   AI454972   AI456596   AI456919   AI518906   AI518930   AI519776   AI532965   AI542884   AI546152   AI946186   AI946515   AQ073361   AW942879   AW944594   AX094301   AZ300980   BE976204   BE976577   BE977640   BE977685   BE977782   BE977869   BE978846   BF502789   BG634147   BG638622   BG638626   BH614994   BI165812   BI168767   BI171179   BI212368   BI213648   BI238765   BI240036   BI372939   BI375308   BI481833   BI578095   BI639605   BP547002   BP559007   BQ102990   BT001330 AAN71085   BT004871 AAO45227   BT011043   BT011384   BT125862   CA803714   CA806461   CL610185   CO177193   CO177199   CO178553   CO179048   CO183866   CO187529   CO187531   CO188187   CO191865   CO194174   CO263877   CO264632   CO266694   CO268172   CO269064   CO269333   CO271098   CO273642   CO277441   CO282267   CO283379   CO283512   CO283881   CO284885   CO285102   CO285625   CO288899   CO291181   CO293257   CO294172   CO294393   CO295076   CO295214   CO296657   CO298267   CO298952   CO300582   CO301150   CO302607   CO304494   CO305629   CO305751   CO310418   CO312200   CO312444   CO313556   CO315443   CO318407   CO324556   CO325691   CO326590   CO330136   CO338067   CO338547   CO338917   CO340234   CO340864   CO344705   CO345174   CZ466637   CZ467209   CZ467210   CZ467509   CZ467799   CZ467800   CZ470351   CZ471134   CZ471180   CZ473091   CZ473092   CZ473719   CZ474118   CZ475598   CZ475612   CZ476803   CZ479574   CZ481077   CZ483625   CZ484328   CZ485373   CZ485374   CZ485628   DN154377   EC053464   EC054442   EC054947   EC056568   EC056789   EC057661   EC064153   EC066281   EC069088   EC069578   EC071157   EC072316   EC073816   EC076060   EC077380   EC079373   EC080988   EC083199   EC084522   EC087019   EC088009   EC088549   EC196003   EC196691   EC197646   EC200856   EC201225   EC202720   EC203130   EC203205   EC204597   EC205792   EC209807   EC211558   EC218599   EC218675   EC219835   EC219992   EC223298   EC223950   EC224272   EC224429   EC229499   EC231910   EC236116   EC236762   EC238320   EC242816   EC243860   EC248631   EC249301   EC251847   EC253548   EC253925   EC254672   EC255210   EC263486   EC265338   EL876970   EL876971   EL877053   EL877054   EL877156   EL877157   EL877261   EL877262   EV575516   EV589421   EV593988   EV598226   GH880400   GH942970   GH943161   GH943286   GH945044   GH946370   GH946426   GH946796   GH946800   GH946905   GH947130   GH947288   GH948513   GH950697   GH950929   GH951530   GH951705   GH951845   GH951893   GH951961   GH952233   GH952432   GH953357   GH953448   GH953828   GH953920   GH955460   GH956582   GH956760   GH958244   GH959555   GH960269   GH961475   GH962258   GH962978   GH963148   GH964055   GH964729   GH964915   GH965232   GH966176   GH966798   GH968102   GH970304   GH970450   GH971168   GH972417   GH974896   GH975300   GH975548   GH975566   GH975670   GH975843   GH976061   GH976136   GH976483   GH977272   GH978491   GH979756   GH981825   GH982259   GH982573   GH982810   GH983048   GH984053   GH985080
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q59DW8 Q86BR9 Q86NK8 Q8IHB0 Q8INB6 Q9VEX2 Q4AB31
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   Kenyon cell | restricted   (Tan et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head | restricted   (Tan et al., 2010) adult mushroom body | restricted   (Tan et al., 2010) calyx of adult mushroom body | restricted   • dendrite (Tan et al., 2010) adult pedunculus | restricted   • axon (Tan et al., 2010) mushroom body beta-lobe | restricted   • axon (Tan et al., 2010) mushroom body beta'-lobe | restricted   • axon (Tan et al., 2010) mushroom body alpha'-lobe | restricted   • axon (Tan et al., 2010) mushroom body alpha-lobe | restricted   • axon (Tan et al., 2010) mushroom body gamma-lobe | restricted   • axon (Tan et al., 2010) adult central complex | restricted   (Tan et al., 2010) ellipsoid body | restricted   (Tan et al., 2010) fan-shaped body | restricted   (Tan et al., 2010) nodulus | restricted   (Tan et al., 2010) protocerebral bridge | restricted   (Tan et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0250823    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0250823 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0250823 expression level Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4011) embryo 02-04hr  (4583) embryo 04-06hr  (3926) embryo 06-08hr  (3720) embryo 08-10hr  (4312) embryo 10-12hr  (2551) embryo 12-14hr  (3568) embryo 14-16hr  (2048) embryo 16-18hr  (2331) embryo 18-20hr  (1418) embryo 20-22hr  (2985) embryo 22-24hr  (3095) larva L1  (1087) larva L2  (1101) larva L3 12hr old  (839) larva L3 puffstage 1-2  (799) larva L3 puffstage 3-6  (1599) larva L3 puffstage 7-9  (2775) white prepupae new  (3209) white prepupae 12hr  (3728) white prepupae 24hr  (3929) pupae 2d postWPP  (3566) pupae 3d postWPP  (2795) pupae 4d postWPP  (2955) adult male 01day  (3552) adult male 05day  (3879) adult male 30day  (3131) adult female 01day  (1690) adult female 05day  (3315) adult female 30day  (2798) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4011) embryo 02-04hr  (4583) embryo 04-06hr  (3926) embryo 06-08hr  (3720) embryo 08-10hr  (4312) embryo 10-12hr  (2551) embryo 12-14hr  (3568) embryo 14-16hr  (2048) embryo 16-18hr  (2331) embryo 18-20hr  1418 embryo 20-22hr  (2985) embryo 22-24hr  (3095) larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6  (1599) larva L3 puffstage 7-9  (2775) white prepupae new  (3209) white prepupae 12hr  (3728) white prepupae 24hr  (3929) pupae 2d postWPP  (3566) pupae 3d postWPP  (2795) pupae 4d postWPP  (2955) adult male 01day  (3552) adult male 05day  (3879) adult male 30day  (3131) adult female 01day  (1690) adult female 05day  (3315) adult female 30day  (2798) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0250823 expression level Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4011) embryo 02-04hr  (4583) embryo 04-06hr  (3926) embryo 06-08hr  (3720) embryo 08-10hr  (4312) embryo 10-12hr  (2551) embryo 12-14hr  (3568) embryo 14-16hr  (2048) embryo 16-18hr  (2331) embryo 18-20hr  (1418) embryo 20-22hr  (2985) embryo 22-24hr  (3095) larva L1  (1087) larva L2  (1101) larva L3 12hr old  (839) larva L3 puffstage 1-2  (799) larva L3 puffstage 3-6  (1599) larva L3 puffstage 7-9  (2775) white prepupae new  (3209) white prepupae 12hr  (3728) white prepupae 24hr  (3929) pupae 2d postWPP  (3566) pupae 3d postWPP  (2795) pupae 4d postWPP  (2955) adult male 01day  (3552) adult male 05day  (3879) adult male 30day  (3131) adult female 01day  (1690) adult female 05day  (3315) adult female 30day  (2798) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4011) embryo 02-04hr  (4583) embryo 04-06hr  (3926) embryo 06-08hr  (3720) embryo 08-10hr  (4312) embryo 10-12hr  (2551) embryo 12-14hr  (3568) embryo 14-16hr  2048 embryo 16-18hr  2331 embryo 18-20hr  1418 embryo 20-22hr  (2985) embryo 22-24hr  (3095) larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6  1599 larva L3 puffstage 7-9  (2775) white prepupae new  (3209) white prepupae 12hr  (3728) white prepupae 24hr  (3929) pupae 2d postWPP  (3566) pupae 3d postWPP  (2795) pupae 4d postWPP  (2955) adult male 01day  (3552) adult male 05day  (3879) adult male 30day  (3131) adult female 01day  1690 adult female 05day  (3315) adult female 30day  (2798) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4011 embryo 02-04hr    4583 embryo 04-06hr    3926 embryo 06-08hr    3720 embryo 08-10hr    4312 embryo 10-12hr    2551 embryo 12-14hr    3568 embryo 14-16hr    2048 embryo 16-18hr    2331 embryo 18-20hr    1418 embryo 20-22hr    2985 embryo 22-24hr    3095 larva L1    1087 larva L2    1101 larva L3 12hr old    839 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1599 larva L3 puffstage 7-9    2775 white prepupae new    3209 white prepupae 12hr    3728 white prepupae 24hr    3929 pupae 2d postWPP    3566 pupae 3d postWPP    2795 pupae 4d postWPP    2955 adult male 01day    3552 adult male 05day    3879 adult male 30day    3131 adult female 01day    1690 adult female 05day    3315 adult female 30day    2798 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0250823    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0250823 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0250823 expression level Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye  (575.075) Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0250823 expression level Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye  575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    253.625 Larval Midgut    159.7 Larval Hindgut    169.2 Larval Malpighian Tubules    190.5 Larval Fat Body    94 Larval Salivary Gland    103.7 Larval Trachea    211.15 Larval Carcass    94.45 Adult Head    148.6 Adult Eye    575.075 Adult Brain    309.4 Adult Thoracic-Abdominal Ganglion    256.1 Adult Crop    138.5 Adult Midgut    190.8 Adult Hindgut    132.3 Adult Malpighian Tubules    143.4 Adult Fat Body    88.7 Adult Salivary Gland    94.7 Adult Heart    139.375 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    413.1 Adult Testis    64.6 Adult Male Accessory Gland    67.6 Adult Carcass    72.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    148.6   NA  Eye    575.075   NA  Brain    309.4   253.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    256.1   NA  Crop    138.5   159.7  Midgut    190.8   169.2  Hindgut    132.3   190.5  Malpighian Tubules    143.4   94  Fat Body    88.7   103.7  Salivary Gland    94.7   NA  Heart    139.375   211.15  Trachea    NA   NA  VirginFemale Spermatheca    60.8   NA  InseminatedFemale Spermatheca    61.5   NA  Ovary    413.1   NA  Testis    64.6   NA  Male Accessory Gland    67.6   94.45  Carcass    72.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250823
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | recessive gishKG03891 viable gishCB02804 gishEY06451 gishEY15206 viable, with Scer\GAL4pnr-MD237 gishGD10588 Sterility Allele fertile gishEY06451 gishEY15206 male sterile gish04895 gishKG03891 male sterile | recessive gish04895 sterile | recessive gishMB896 Other Phenotypes Allele increased cell death, with Scer\GAL4ptc-559.1 gishEP3652 memory defective | dominant gish04895 gishKG03891 memory defective | semidominant gishMB896 visible gish1 visible, with Scer\GAL4pnr-MD237 gishGD10588 Phenotype manifest in Allele eye gish1 lamina anlage glial cell | ectopic gish1 lamina anlage glial cell | ectopic | somatic clone gish1 lamina neuropil | ectopic gish1 lamina neuropil | ectopic | somatic clone gish1 morphogenetic furrow | somatic clone gish1 ommatidium gish1 photoreceptor cell gish1 spermatogonium, with Scer\GAL4ptc-559.1 gishEP3652 subretinal glial cell | ectopic gish1 subretinal glial cell | ectopic | somatic clone gish1 trichogen cell, with Scer\GAL4pnr-MD237 gishGD10588
Classical Alleles ( 46 )
For All Classical Alleles Show
Allele of gish Class Mutagen Stocks Known lesion gish04895 P-element activity 1 Yes gishB184 1 -- gishc00662 piggyBac transposase 1 -- gishc02243 piggyBac transposase 1 -- gishc05910 piggyBac transposase 1 -- gishc06974 piggyBac transposase 1 -- gishCB-6487-3 1 -- gishd02946 P-element activity 1 -- gishd04764 P-element activity 1 -- gishd07242 P-element activity 1 -- gishDG16412 P-element activity 1 -- gishe01759 piggyBac transposase 1 -- gishEY06451 P-element activity 1 -- gishEY15206 P-element activity 1 -- gishf01138 piggyBac transposase 1 -- gishf01841 piggyBac transposase 1 -- gishf02822 piggyBac transposase 1 -- gishf03068 piggyBac transposase 1 -- gishGS10076 1 Yes gishKG03891 P-element activity 1 Yes gishMI00340 1 -- gishNP1352 1 -- gishNP2152 1 -- gishNP3014 1 -- gishNP5387 1 -- gishNP5405 1 -- gish1 0 Yes gishc01041 0 -- gishc01495 piggyBac transposase 0 -- gishc01861 piggyBac transposase 0 -- gishCB02804 P-element activity 0 Yes gishCPTI002023 piggyBac transposase 0 Yes gishCPTI004113 piggyBac transposase 0 Yes gishd04071 P-element activity 0 -- gishd07219 P-element activity 0 -- gishd09551 P-element activity 0 -- gishe03307 piggyBac transposase 0 -- gishEP3057 P-element activity 0 -- gishEP3652 P-element activity 0 -- gishEP3726 P-element activity 0 -- gishf05275 0 -- gishG38 P-element activity 0 Yes gishMB896 0 Yes gishP144 P-element activity 0 Yes gishP232 P-element activity 0 Yes gishSpider 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of gish Class Mutagen Stocks Known lesion gishGD10588 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gishGL00005 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gishJF02903 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gishKK108680 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gishL.Scer\UAS in vitro construct - regulatory fusion 0 Yes gishS.Scer\UAS in vitro construct - regulatory fusion 0 Yes gishScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes gishScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes gishScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)bxd100 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Exel6268 (Ryder, 2004.4.26) Df(3R)Exel7329 (Ryder, 2004.4.26)
Not disrupted in	Df(3R)sbd105 (Kennison, 1995.6.21)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10588} NA P{KK108680} NA P{TRiP.GL00005} NA P{TRiP.JF02903} NA P{UAS-gish.FLAG} NA P{UAS-gish.H} NA P{UAS-gish.L} NA P{UAS-gish.S} NA P{UAS-gish.T} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}gishP144 No P{lacW}gishP232 No P{lArB}gishMB896 No P{PZ}gish04895 No insertion of mobile activating element P{EP}gishEP3057 NA P{EP}gishEP3652 NA P{EP}gishEP3726 NA P{EPgy2}gishEY06451 NA P{EPgy2}gishEY15206 NA P{GSV1}EP-207EP-207 NA P{GSV6}gishGS10076 NA P{XP}gishd02946 NA P{XP}gishd04071 NA P{XP}gishd04764 NA P{XP}gishd07219 NA P{XP}gishd07242 NA P{XP}gishd09551 NA miscellaneous insertions ?{}gish1 NA Mi{MIC}gishMI00340 NA P{CaryP}attP52 NA P{PTT-GB}gishCB02804 NA P{PTT-un1}gishG38 NA P{PTT-un1}gishSpider NA P{RS3}gishCB-6487-3 NA P{SUPor-P}gishKG03891 NA P{wHy}gishDG16412 NA PBac{5HPw+}gishB184 NA PBac{681.P.FSVS-1}gishCPTI002023 NA PBac{806.LOX-SVS-2}gishCPTI004113 NA PBac{PB}gishc00662 NA PBac{PB}gishc01041 NA PBac{PB}gishc01495 NA PBac{PB}gishc01861 NA PBac{PB}gishc02243 NA PBac{PB}gishc05910 NA PBac{PB}gishc06974 NA PBac{PB}gishc07032 NA PBac{RB}gishe01759 NA PBac{RB}gishe03307 NA PBac{WH}gishf01138 NA PBac{WH}gishf01841 NA PBac{WH}gishf02822 NA PBac{WH}gishf03068 NA PBac{WH}gishf05275 NA insertion of enhancer trap binary system P{GawB}gishNP1352 No P{GawB}gishNP2152 No P{GawB}gishNP3014 No P{GawB}gishNP5387 No P{GawB}gishNP5405 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
glial cell migration inferred from mutant phenotype (Hummel et al., 2001, Hummel et al., 2002) olfactory learning inferred from mutant phenotype (Tan et al., 2010) protein phosphorylation inferred from direct assay (Zhang et al., 2006) spermatogenesis inferred from mutant phenotype (Castrillon et al., 1993) Wnt receptor signaling pathway inferred from mutant phenotype (Zhang et al., 2006)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Frescas et al., 2006, Zhang et al., 2006, Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Spradling et al., 1999) inferred from sequence or structural similarity with UniProtKB:Q62763 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions gish allele Gene References gish1 ey (Hummel et al., 2002) hh (Hummel et al., 2002) so (Hummel et al., 2002) unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72425 DroID - A comprehensive database of gene and protein interactions. • FBgn0250823 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49701
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18486 Dere\GG16991 Dgri\GH19542 Dmoj\GI22941 Dper\GL21596 Dpse\GA19988 Dsec\GM15143 Dsim\GD19086 Dvir\GJ23721 Dwil\GK13771 Dyak\GE24384
Curated drosophilid orthologs	Dpse\GA19988
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004351-PC Aedes aegypti (mosquito) AGAP003997-PA Anopheles gambiae (mosquito) XP_394307.3 Apis mellifera (honey bee) XP_001951970.1 Acyrthosiphon pisum (pea aphid) 84994 Batrachochytrium dendrobatidis (chytrid fungus) 125993 Branchiostoma floridae (lancelet) XP_001898636.1 Brugia malayi (roundworm nematode) BGIBMGA001512-PA Bombyx mori (silk worm) ENSBTAP00000022379 Bos taurus (bovine) CAL0001885 Candida albicans (a form of yeast) CBP28657 Caenorhabditis briggsae (nematode) CE29604 Caenorhabditis elegans (worm) ENSCAFP00000000799 Canis familiaris (dog) CAGL0J05940g Candida glabrata (haploid yeast) ENSCINP00000018219 Ciona intestinalis (sea squirt) cn01529 Cryptococcus neoformans (yeast-like fungus) CPIJ008898 Culex pipens (mosquito) ENSCPOP00000000227 Cavia porcellus (guinea pig) RP22289 Caenorhabditis remanei (nematode) ENSCSAVP00000009229 Ciona savignyi (sedentary tunicate) 171731 Capitella spl (polychaete worm) DEHA2D03762g Debaryomyces Hansenii (yeast) 23401 Daphnia pulex (daphnia) ENSDARP00000056920 Danio rerio (zebra fish) ENSECAP00000017254 Equus caballus (horse) ENSGACP00000019361 Gymnopilus aculeatus (mushroom) ENSGALP00000003568 Gallus gallus (chicken) 109405 Hypsipyla robusta (cedar shoot borer) ENSP00000378807 Homo sapiens (human) ISCW009144-PA Ixodes scapularis (deer tick) KLLA0D11044g Kluyveromyces lactis (yeast) 178639 Lottia gigantea (owl limpet) 25267 Monocosta brevicollis (choanoflagellate) ENSMODP00000013540 Monodelphis domestica (gray opossum) ENSMMUP00000008742 Macaca mulatta (rhesus monkey) ENSMUSP00000034949 Mus musculus (house mouse) 192152 Nematostella vectensis (starlet anemone) XP_001607046.1 Nasonia vitripennis (wasp) ENSOANP00000018308 Ornithorynchus anatinus (platypus) ENSORLP00000009877 Oryzias latipes (japanese killifish) PHUM002652-PA Pediculus humanus (human body louse) ENSPPYP00000017584 Pongo pygmaeus (orangutan) ENSPTRP00000054505 Pan troglodytes (chimpanzee) ENSRNOP00000022792 Rattus norvegicus (norway rat) YNL154C Saccharomyces cerevisiae (budding yeast) Smp_180400 Schistosoma mansoni (trematode parasite) SPAC1805.05 Schizosaccharomyces pombe (fission yeast) XP_001176084.1 Strongylocentrotus purpuratus (purple sea urchin) 22371 Trichoplax adhaerens (metazoa) XP_966606.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012447 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011523 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022613 Xenopus tropicalis (frog) YALI0E26609g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13701 LH11855 ISCW009144 FBgn0241504 FBgn0215779 FBgn0210818 FBgn0190593 FBgn0170063 JGI_V11_23401 FBgn0079984 FBgn0159189 FBgn0145668 FBgn0127007 FBgn0109219 FBgn0095504 CPIJ008898 BGIBMGA001512 ACYPI008713 GB10086 AGAP003997 AAEL004351 PB26030 PHUM048320 GLEAN_01738
Stocks & Reagents
Stocks Listed in FlyBase ( 30 )
Harvard	- P{XP}gishd02946 - P{XP}gishd04764 - P{XP}gishd07242 - PBac{PB}gishc00662 - PBac{PB}gishc02243 - PBac{PB}gishc05910 - PBac{PB}gishc06974 - PBac{RB}gishe01759 - PBac{WH}gishf01138 - PBac{WH}gishf01841 - PBac{WH}gishf02822
VDRC	v106826 P{KK108680}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR05P04 BACR37I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 244 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT18609 LD28216 LD30931 LD31233 SD09393
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30246 GM03462 GM04463 GM04971 LD01021 LD01514 LD04357 LD08007 LD08116 LD09417 LD10476 LD20615 LD28505 LD30581 LD35770 LD36665 LD37086 LD39541 LD46246 LP05389 RE05771 RE09637 RE12879 RE17459 RE19092 RE36679 RE41831 RE60139 RE63082 RE64439 RE71895 SD04628 SD22236
Other clones	5325 11141 29018 30627 36524 52483 57982 59763 66263 69878 73203 73912 76212 78446 78938 79281 99142 101793 105977 107442 108432 121016 121023 122832 146146 146771 156052 157471 176359 214211.33 214341.37 214417.30 214437.40 281648 571243 572782 bs21h06 bs27c08 bs48b01 bs53c11 bs67c03 bs67g03 bs69a07 bs70c03 bs83e12 CK01.33C.F7 CK01.33D.H5 CK01.39A.G12 CK01.63A.E10 CK01.67A.E4 CK01.71D.A10 CK01.74A.G6 CK01.77B.H8 CK01.88C.G9 CK01.98D.H9 CK01.107C.B4 CK01.115B.G5 CK01.122B.F10 CK01.122C.C4 CK01.133B.E4 CK01.170C.D12 Dmel_dig_008057_0717_1285 Dmel_neb_012499_0403_2992 Dmel_neb_013193_0592_0402 Dmel_neb_015522_0827_0485 EC26560 EC32303 EC37560 EC053464 EC054442 EC054947 EC056568 EK030213 EK030216 EK038317 EK052734 EK052750 EK057026 EK058259 EK069627 EK076429 EK090438 EK093453 EK094142 EK101950 EK111716 EK124429 EK136739 EK139754 EK147242 EK160121 EK162963 EK163452 EK164721 EK167314 EK168218 EK169710 EK172645 EK174159 EK178637 EK180243 EK184538 EK194230 EK197213 EK202249 EK206238 EK206824 EK208604 EK208931 EK214604 EK221609 EK228053 EK228825 EK231613 EK233352 EK244848 EK249130 EK249344 EK261508 EK272016 EK294607 EN15903 EN17045 EP00304 EP04252 EP10245 EP11460 EP19746 EP21527 ESG013c.E21_A11 ESG0110a.E21_H10 FGH112D04 FGM318C11 HL07970 IP06893 IP06993 IP07093 IP07193 LD31187 RP003412691 RP004039280 RP004073458 RP004075340 RP004096764 RP004122492 RP004124087 RP004129131 RP004131453 RP004144925 RP004146480 RP004151000 RP004152064 RP004152731 RP004155836 RP004163381 RP004164740 RP004168798 RP004195493 RP004202501 RP004210581 RP004212961 RP004215015 RP004215089 RP004216059 RP004216079 RP004216716 RP004219570 RP004220038 RP004220530 RP004223666 RP004227351 RP004235083 RP004236657 RP004246271 RP004251471 RP004251758 RP004256622 RP004259380 RP004296962 RP004318708 RP004326512 RP004327912 RP004333932 RP004337381 RP004339466 RP004339961 RP004345865 RP004354403 RP004397762 RP004416603 RP004427130 RP004428506 RP004459906 RP004475722 RP004483292 RP004494896 RP004497897 RP004500744 RP004508575 RP004517525 RP004519642 RP004526473 RP004534690 RP004546857 RP004556318 UUGC0384
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0250823 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49701
Antibody Information
	polyclonal (Tan et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: gish CKI-related (Hummel, 2001.3.14)
Source for database merge of	Source for merge of: CKI-related CG6963 (Misra, 2000.8.9) Source for merge of: gish anon-WO0118547.425 (FlyBase, 1996-) Source for merge of: gish NEST:bs27c08 (FlyBase, 1996-)
Additional comments	Source for merge of gish anon-WO0118547.425 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	The gish product phosphorylates the arr protein. (Zhang et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells and/or aneuploidy, an increase in the proportion of G2/M phase cells, and increase in in mitotic index, and spindle abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) gish, so, ey and hh act in the posterior region of the eye disc to prevent precocious glial cell migration. (Hummel et al., 2002) Area matching Drosophila EST AA949934. This EST has sequence similarity to mammalian Casein kinase genes. (Davies, 2001.3.15) gish may be part of a repulsive signaling mechanism coordinating glial migration and neuronal development in the developing eye. (Hummel et al., 2001) In mutants, glial cells prematurely migrate into the ectopic positions anterior to the photoreceptors. As a consequence, a subset of photoreceptor axons projects anteriorly, suggesting an instructive role for the glial cells in axon pathfinding. Furthermore, gish mutant glial cells also inappropriately adhere to and migrate along Bolwigs nerve. (Hummel et al., 2001) Postmeiotic differentiation defect. (Castrillon et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080202 NM_169711 NM_169712 NM_169713 NM_176506 NM_001014626 NM_001014627 NM_001014628 NM_001170157 RefSeq (Proteins) • NP_524941 NP_732123 NP_732124 NP_732125 NP_788683 NP_001014626 NP_001014627 NP_001014628 NP_001163628 DDBJ / EMBL / GenBank • AA201386 AA264321 AA949351 AA949934 AA950799 AAF55293 AAF55293.1 AAF55294 AAF55294.2 AAN13703 AAN13703.2 AAN13704 AAN13704.2 AAN71085 AAO41569 AAO41569.1 AAO45227 AAX52956 AAX52957 AAX52958 ACZ94924 AI456919 AI542884 AI946186 AI946515 AQ073361 AW942879 AW944594 AX094301 AZ300980 BF502789 BG638622 BH614994 BT001330 BT004871 CL610185 CZ466637 CZ467209 CZ467210 CZ467509 CZ467799 CZ467800 CZ470351 CZ471134 CZ471180 CZ473091 CZ473092 CZ473719 CZ474118 CZ475598 CZ475612 CZ476803 CZ479574 CZ481077 CZ483625 CZ484328 CZ485373 CZ485374 CZ485628 Entrez Gene - A searchable database of RefSeq genes. • 49701 UniProtKB/TrEMBL • Q4AB31 Q8IHB0 Q8INB6 Q9VEX2 Q59DW8 Q86BR9 Q86NK8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Casein kinase 1 gamma C-terminal (IPR022247)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72425 DroID - A comprehensive database of gene and protein interactions. • FBgn0250823 DRSC - Results from RNAi screens. • FBgn0250823 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0250823 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0250823 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205601 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49701 InParanoid A subset of ortholog calls from InParanoid. • AAEL004351-PC Aedes aegypti (mosquito) AGAP003997-PA Anopheles gambiae (mosquito) XP_394307.3 Apis mellifera (honey bee) XP_001951970.1 Acyrthosiphon pisum (pea aphid) 84994 Batrachochytrium dendrobatidis (chytrid fungus) 125993 Branchiostoma floridae (lancelet) XP_001898636.1 Brugia malayi (roundworm nematode) BGIBMGA001512-PA Bombyx mori (silk worm) ENSBTAP00000022379 Bos taurus (bovine) CAL0001885 Candida albicans (a form of yeast) CBP28657 Caenorhabditis briggsae (nematode) CE29604 Caenorhabditis elegans (worm) ENSCAFP00000000799 Canis familiaris (dog) CAGL0J05940g Candida glabrata (haploid yeast) ENSCINP00000018219 Ciona intestinalis (sea squirt) cn01529 Cryptococcus neoformans (yeast-like fungus) CPIJ008898 Culex pipens (mosquito) ENSCPOP00000000227 Cavia porcellus (guinea pig) RP22289 Caenorhabditis remanei (nematode) ENSCSAVP00000009229 Ciona savignyi (sedentary tunicate) 171731 Capitella spl (polychaete worm) DEHA2D03762g Debaryomyces Hansenii (yeast) 23401 Daphnia pulex (daphnia) ENSDARP00000056920 Danio rerio (zebra fish) ENSECAP00000017254 Equus caballus (horse) ENSGACP00000019361 Gymnopilus aculeatus (mushroom) ENSGALP00000003568 Gallus gallus (chicken) 109405 Hypsipyla robusta (cedar shoot borer) ENSP00000378807 Homo sapiens (human) ISCW009144-PA Ixodes scapularis (deer tick) KLLA0D11044g Kluyveromyces lactis (yeast) 178639 Lottia gigantea (owl limpet) 25267 Monocosta brevicollis (choanoflagellate) ENSMODP00000013540 Monodelphis domestica (gray opossum) ENSMMUP00000008742 Macaca mulatta (rhesus monkey) ENSMUSP00000034949 Mus musculus (house mouse) 192152 Nematostella vectensis (starlet anemone) XP_001607046.1 Nasonia vitripennis (wasp) ENSOANP00000018308 Ornithorynchus anatinus (platypus) ENSORLP00000009877 Oryzias latipes (japanese killifish) PHUM002652-PA Pediculus humanus (human body louse) ENSPPYP00000017584 Pongo pygmaeus (orangutan) ENSPTRP00000054505 Pan troglodytes (chimpanzee) ENSRNOP00000022792 Rattus norvegicus (norway rat) YNL154C Saccharomyces cerevisiae (budding yeast) Smp_180400 Schistosoma mansoni (trematode parasite) SPAC1805.05 Schizosaccharomyces pombe (fission yeast) XP_001176084.1 Strongylocentrotus purpuratus (purple sea urchin) 22371 Trichoplax adhaerens (metazoa) XP_966606.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012447 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011523 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022613 Xenopus tropicalis (frog) YALI0E26609g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49701 modMine - Data generated by the modENCODE project. • FBgn0250823 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13701 LH11855 ISCW009144 FBgn0241504 FBgn0215779 FBgn0210818 FBgn0190593 FBgn0170063 JGI_V11_23401 FBgn0079984 FBgn0159189 FBgn0145668 FBgn0127007 FBgn0109219 FBgn0095504 CPIJ008898 BGIBMGA001512 ACYPI008713 GB10086 AGAP003997 AAEL004351 PB26030 PHUM048320 GLEAN_01738
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-WO0118547.425   CG6963 (Morin et al., 2001, Brody et al., 2002, Hummel, 2001.3.14, Morrison et al., 2000, Molnar et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Khanna et al., 2010, Ni et al., 2011.7.19) CK1 (Nerusheva et al., 2007) CK1γ (Davidson et al., 2009) CKI-related   CKIγ (Hummel et al., 2002, Jia et al., 2005) gish (Tan et al., 2010, Liebl et al., 2006, Nerusheva et al., 2007, Jia et al., 2005, Stuart et al., 2007, Buszczak et al., 2007, Molnar et al., 2006, Markstein et al., 2008, Rathke et al., 2007, Nerusheva et al., 2009, Bozas et al., 2009, Davidson et al., 2009, Mattila et al., 2008) Gish (Zhang et al., 2006) Hrr25 (Spradling, 1999.12.9, Spradling et al., 1999, ) ms(3)89B (Meister and Braun, 1995.10, Kennison, 1995.6.21, BDGP Project Members, 1994-1999, Castrillon et al., 1993, ) NEST:bs27c08
Name Synonym	CKIg-like (Morrison et al., 2000) gilgamesh (Tan et al., 2010, Hummel, 2001.3.14, Hummel et al., 2001, Gregory et al., 2007, Frescas et al., 2006, Pandey et al., 2005, Rathke et al., 2007, Nerusheva et al., 2009, Bozas et al., 2009) Gilgamesh (Zhang et al., 2006, Shalaby et al., 2009, Khanna et al., 2010) NEST:bs27c08   Spider (Martin et al., 2009, Cao et al., 2008, Martin et al., 2010, Abreu-Blanco et al., 2011) spider (Fernandez-Gonzalez et al., 2009)
Secondary FlyBase IDs
	FBgn0011253 FBgn0038411 FBgn0045173 FBgn0062017
References ( 77 )
Generate a list of	All references relating to this gene ( 77 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 21 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Computer file  ( 4 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Abreu-Blanco et al., 2011, J. Cell Biol. 193(3): 455--464 Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. [FBrf0213583] Martin et al., 2010, J. Cell Biol. 188(5): 735--749 Integration of contractile forces during tissue invagination. [FBrf0210158] Tan et al., 2010, Neuron 67(5): 810--820 Gilgamesh Is Required for rutabaga-Independent Olfactory Learning in Drosophila. [FBrf0211760] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...