Gene model reviewed during 5.44
Gene model reviewed during 5.47
1.6 (northern blot)
415 (aa); 44 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgk using the Feature Mapper tool.
Maternally derived Pgk transcripts are found at substantial levels in early embryos. Transcript levels decline until mid-embryogenesis and then rise. Transcript levels remain high during larval stages, decline at pupariation, rise again at emergence, and remain high in the adult.
Transcript levels are unaltered by dietary variations in the level of glucose, fructose, starch, or ethanol. A small increase is seen on 5% sucrose vs. 0.3% sucrose.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pgk in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Pgk l(2)23AB3
Pgk mutants display reduced lifespan, abnormal motor behavior, altered synaptic structure, and defective neurotransmitter release.
Pgk gene cloned by homology to human Pgk. DNA sequence and temporal pattern of expression determined.
Modulation of Gpdh, Ald, Pgk and RpL32 proteins and their transcript levels was investigated in larvae. No increase in transcript level or PGK activity was seen with an increase in sucrose, glucose, fructose, starch or dietary ethanol levels.
No null alleles reported out of a total of 702 alleles collected in North Carolina (Langley et al., 1981).
Structural gene for 3-phosphoglycerate kinase (3-PGK). Three electrophoretic variants (fast, intermediate, slow) isolated by Chew and Cooper (1973), the heterozygotes showing no hybrid band; two electrophoretic variants isolated by Voelker et al. (1979).