FlyBase Gene Report: Dmel\Octβ3R

General Information

Symbol

Dmel\Octβ3R

Species

D. melanogaster

Name

Octopamine β3 receptor

Annotation Symbol

CG42244

Feature Type

protein_coding_gene

FlyBase ID

FBgn0250910

Gene Model Status

Current

Stock Availability

25 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

OctBeta3, DmOctβ3R

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:12,511,570..12,548,229 [-]

Recombination map

3-52

RefSeq locus

NT_033777 REGION:12511570..12548229

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables octopamine receptor activity

inferred from direct assay

(Maqueira et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(assigned by GO_Central )

(Gaudet et al., 2011)

enables octopamine receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001206597

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q9VCZ3

(Maqueira et al., 2005)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from direct assay

(Maqueira et al., 2005)

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Maqueira et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating adrenergic receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity with UniProtKB:Q9VCZ3

(Maqueira et al., 2005)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Maqueira et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

located_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OCTOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q4LBB6)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

OCTOPAMINE RECEPTORS -: Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).

Protein Function (UniProtKB)

Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909).

(UniProt, Q4LBB6)

Summary (Interactive Fly)

G-protein coupled receptor, monoaminergic autocrine signaling, body size checkpoint, nutrient dependence of metamorphosis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Octβ3R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.39

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Octβ3R-RF

FBtr0290334

NM_001038959

6101

1256

Octβ3R-RG

FBtr0290335

NM_141953

5687

1118

Octβ3R-RJ

FBtr0301944

NM_001038954

3668

445

Octβ3R-RK

FBtr0308597

NM_001038957

3817

456

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Octβ3R-PF

FBpp0288773

136.4

1256

6.41

NP_001034048

ABC66173

Octβ3R-PG

FBpp0288774

121.5

1118

5.64

NP_650210

AAF54832

Octβ3R-PJ

FBpp0291156

48.9

445

6.83

NP_001034043

ABC66171

Octβ3R-PK

FBpp0300821

49.4

456

7.08

NP_001034046

ABC66172

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q4LBB6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Octβ3R using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Octbeta3R_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval brain

(El-Kholy et al., 2015)

embryonic/larval Malpighian tubule

(El-Kholy et al., 2015)

adult stage

adult brain

(El-Kholy et al., 2015)

adult Malpighian tubule

(El-Kholy et al., 2015)

adult trachea

(El-Kholy et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Maqueira et al., 2005)

Expression Deduced from Reporters

Reporter: P{Octβ3R-GAL4.E}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval sensillum | restricted

(El-Kholy et al., 2015)

embryonic/larval Malpighian tubule

(El-Kholy et al., 2015)

embryonic/larval central nervous system | restricted

(El-Kholy et al., 2015)

embryonic/larval mushroom body

(El-Kholy et al., 2015)

larval abdominal neuromere | intense | restricted

(El-Kholy et al., 2015)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Octβ3R in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Octβ3R

View exonic expression by tissue for Dmel\Octβ3R

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0250910

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG18554-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0250910

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Octβ3R

Transgenic constructs containing regulatory region of Octβ3R

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)Exel7317

(Ryder, 2004.4.26)

Partially disrupted in

Df(3R)Hug^attP

(Rao and Deng, 2019.10.23)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

flightless, with Scer\GAL4^Mef2.PR

Octβ3R^GD2952

sleep defective | adult stage

Octβ3R^KOGal4

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HTR4

5 of 15

Yes

Hsap\ADRB1

3 of 15

Hsap\ADRB2

3 of 15

Hsap\ADRB3

3 of 15

Yes

Hsap\HRH2

2 of 15

Yes

Hsap\DRD1

1 of 15

Hsap\DRD5

1 of 15

Hsap\GPR148

1 of 15

Yes

Hsap\TAAR1

1 of 15

Yes

Hsap\TAAR2

1 of 15

Yes

Hsap\TAAR3P

1 of 15

Yes

Hsap\TAAR5

1 of 15

Yes

Hsap\TAAR6

1 of 15

Yes

Hsap\TAAR8

1 of 15

Yes

Hsap\TAAR9

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Htr4

5 of 15

Yes

Mmus\Adrb1

3 of 15

Mmus\Adrb2

3 of 15

Mmus\Adrb3

3 of 15

Yes

Mmus\Hrh2

2 of 15

Yes

Mmus\Drd1

1 of 15

Mmus\Drd5

1 of 15

Mmus\Taar1

1 of 15

Yes

Mmus\Taar2

1 of 15

Yes

Mmus\Taar3

1 of 15

Yes

Mmus\Taar4

1 of 15

Yes

Mmus\Taar5

1 of 15

Yes

Mmus\Taar6

1 of 15

Yes

Mmus\Taar7a

1 of 15

Yes

Mmus\Taar7b

1 of 15

Yes

Mmus\Taar7d

1 of 15

Yes

Mmus\Taar7e

1 of 15

Yes

Mmus\Taar7f

1 of 15

Yes

Mmus\Taar8a

1 of 15

Yes

Mmus\Taar8b

1 of 15

Yes

Mmus\Taar8c

1 of 15

Yes

Mmus\Taar9

1 of 15

Yes

Rattus norvegicus (Norway rat) (22)

Rnor\Htr4

5 of 13

Yes

Rnor\Adrb1

3 of 13

Rnor\Adrb2

3 of 13

Rnor\Adrb3

3 of 13

Yes

Rnor\Taar7h

2 of 13

Yes

Rnor\Drd5

1 of 13

Rnor\Hrh2

1 of 13

Yes

Rnor\LOC100910174

1 of 13

Yes

Rnor\Taar1

1 of 13

Yes

Rnor\Taar2

1 of 13

Yes

Rnor\Taar3

1 of 13

Yes

Rnor\Taar4

1 of 13

Yes

Rnor\Taar5

1 of 13

Yes

Rnor\Taar6

1 of 13

Yes

Rnor\Taar7a

1 of 13

Yes

Rnor\Taar7b

1 of 13

Yes

Rnor\Taar7d

1 of 13

Yes

Rnor\Taar7e

1 of 13

Yes

Rnor\Taar7g

1 of 13

Yes

Rnor\Taar8b

1 of 13

Yes

Rnor\Taar8c

1 of 13

Yes

Rnor\Taar9

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\htr4

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC100490372

1 of 12

Danio rerio (Zebrafish) (86)

Drer\adrb1

2 of 15

Yes

Drer\adrb2a

2 of 15

Yes

Drer\adrb2b

2 of 15

Yes

Drer\adrb3a

2 of 15

Yes

Drer\adrb3b

2 of 15

Yes

Drer\hrh2b

2 of 15

Yes

Drer\si:dkey-247m21.3

2 of 15

Yes

Drer\taar12a

2 of 15

Yes

Drer\taar12b

2 of 15

Yes

Drer\taar12c

2 of 15

Yes

Drer\taar12e

2 of 15

Yes

Drer\taar12f

2 of 15

Yes

Drer\taar12g

2 of 15

Yes

Drer\taar12h

2 of 15

Yes

Drer\taar12i

2 of 15

Yes

Drer\taar12j

2 of 15

Yes

Drer\taar12m

2 of 15

Yes

Drer\taar19t

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\si:ch211-238p8.18

1 of 15

Yes

Drer\si:ch211-238p8.24

1 of 15

Yes

Drer\si:dkey-181m19.17

1 of 15

Yes

Drer\taar1b

1 of 15

Yes

Drer\taar10a

1 of 15

Yes

Drer\taar10b

1 of 15

Yes

Drer\taar10c

1 of 15

Yes

Drer\taar10d

1 of 15

Yes

Drer\taar10

1 of 15

Yes

Drer\taar11

1 of 15

Yes

Drer\taar13a

1 of 15

Yes

Drer\taar13b

1 of 15

Yes

Drer\taar13c

1 of 15

Yes

Drer\taar13d

1 of 15

Yes

Drer\taar13e

1 of 15

Yes

Drer\taar14b

1 of 15

Yes

Drer\taar14h

1 of 15

Yes

Drer\taar16f

1 of 15

Yes

Drer\taar16g

1 of 15

Yes

Drer\taar17a

1 of 15

Yes

Drer\taar18a

1 of 15

Yes

Drer\taar18b

1 of 15

Yes

Drer\taar18c

1 of 15

Yes

Drer\taar18d

1 of 15

Yes

Drer\taar18g

1 of 15

Yes

Drer\taar18h

1 of 15

Yes

Drer\taar18i

1 of 15

Yes

Drer\taar18j

1 of 15

Yes

Drer\taar19a

1 of 15

Yes

Drer\taar19b

1 of 15

Yes

Drer\taar19c

1 of 15

Yes

Drer\taar19d

1 of 15

Yes

Drer\taar19g

1 of 15

Yes

Drer\taar19j

1 of 15

Yes

Drer\taar19k

1 of 15

Yes

Drer\taar19o

1 of 15

Yes

Drer\taar19r

1 of 15

Yes

Drer\taar19s

1 of 15

Yes

Drer\taar20a1

1 of 15

Yes

Drer\taar20a

1 of 15

Yes

Drer\taar20b1

1 of 15

Yes

Drer\taar20b

1 of 15

Yes

Drer\taar20c1

1 of 15

Yes

Drer\taar20c

1 of 15

Yes

Drer\taar20d1

1 of 15

Yes

Drer\taar20h

1 of 15

Yes

Drer\taar20i

1 of 15

Yes

Drer\taar20j

1 of 15

Yes

Drer\taar20l

1 of 15

Yes

Drer\taar20n

1 of 15

Yes

Drer\taar20o

1 of 15

Yes

Drer\taar20r

1 of 15

Yes

Drer\taar20t

1 of 15

Yes

Drer\taar20u

1 of 15

Yes

Drer\taar20v

1 of 15

Yes

Drer\taar20w

1 of 15

Yes

Drer\taar20x

1 of 15

Yes

Drer\taar20z

1 of 15

Yes

Drer\zgc:162592

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\C01F1.4

1 of 15

Yes

Cele\F59D12.1

1 of 15

Yes

Cele\npr-1

1 of 15

Yes

Cele\ser-5

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901TF )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00012258

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011629

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26829

Drosophila persimilis

Dper\GL13572

Drosophila willistoni

Dwil\GK13570

Drosophila virilis

Dvir\GJ10602

Drosophila mojavensis

Dmoj\GI23112

Drosophila grimshawi

Dgri\GH18897

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AWD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17023295

Glossina morsitans

Tsetse fly

Gmor\GMOY003496

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11899

Mayetiola destructor

Hessian fly

Mdes\Mdes002520

Aedes aegypti

Yellow fever mosquito

Aaeg\GPRDOP5

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003873

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B2C )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BmOAR2.1

Bombyx mori

Silkmoth

Bmor\BGIBMGA002248

Bombyx mori

Silkmoth

Bmor\BGIBMGA002249

Bombyx mori

Silkmoth

Bmor\BGIBMGA002326

Danaus plexippus

Monarch butterfly

Dple\DPOGS205366-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200581-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209108-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002743

Heliconius melpomene

Postman butterfly

Hmel\HMEL014462

Heliconius melpomene

Postman butterfly

Hmel\HMEL009712

Apis florea

Little honeybee

Aflo\5278539204

Apis florea

Little honeybee

Aflo\3651180356

Apis florea

Little honeybee

Aflo\4501543908

Apis mellifera

Western honey bee

Amel\GB52879

Apis mellifera

Western honey bee

Amel\oa2

Apis mellifera

Western honey bee

Amel\GB52878

Apis mellifera

Western honey bee

Amel\GB49696

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21653

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11589

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11590

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11588

Bombus terrestris

Buff-tailed bumblebee

Bter\15202637

Bombus terrestris

Buff-tailed bumblebee

Bter\15207086

Bombus terrestris

Buff-tailed bumblebee

Bter\15202817

Bombus terrestris

Buff-tailed bumblebee

Bter\15207087

Linepithema humile

Argentine ant

Lhum\LH12970

Linepithema humile

Argentine ant

Lhum\LH12975

Linepithema humile

Argentine ant

Lhum\LH12976

Linepithema humile

Argentine ant

Lhum\LH20188

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d42

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00234b

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d44

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d43

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001703

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00011

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12979

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12851

Tribolium castaneum

Red flour beetle

Tcas\TC012597

Tribolium castaneum

Red flour beetle

Tcas\TC012598

Tribolium castaneum

Red flour beetle

Tcas\TC012600

Pediculus humanus

Human body louse

Phum\PHUM549550

Pediculus humanus

Human body louse

Phum\PHUM027040

Pediculus humanus

Human body louse

Phum\PHUM497230

Rhodnius prolixus

Kissing bug

Rpro\RPRC011545

Rhodnius prolixus

Kissing bug

Rpro\RPRC014610

Rhodnius prolixus

Kissing bug

Rpro\RPRC005349

Cimex lectularius

Bed bug

Clec\CLEC025394

Cimex lectularius

Bed bug

Clec\CLEC025157

Cimex lectularius

Bed bug

Clec\CLEC025161

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI010025

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004658

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007386

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13825

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13827

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10946

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09X5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013184

Ixodes scapularis

Black-legged tick

Isca\ISCW008552

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60041.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60165.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04980

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_347041

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (17)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ADRB2; adrenoceptor beta 2

model of obesity

IEA

(FlyBase, 2019-)

ADRB3; adrenoceptor beta 3

model of obesity

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HTR4; 5-hydroxytryptamine receptor 4

5 of 15

602164

ADRB1; adrenoceptor beta 1

3 of 15

109630

ADRB2; adrenoceptor beta 2

3 of 15

109690

ADRB3; adrenoceptor beta 3

3 of 15

109691

OBESITY

obesity

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0250910

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-52

Cytogenetic map

87B15-87C1

Sequence location

3R:12,511,570..12,548,229 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87B15-87C1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-52

(FlyBase, 2016)

3-49.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (25)

Bloomington

86144

TI{2A-GAL4}Octβ3R^2A-GAL4.KI

86287

TI{2A-lexA::GAD}Octβ3R^2A-lexA.KI

83046

y¹ v¹; M{WKO.1-A2}ZH-86Fb

24819

w¹¹¹⁸; Mi{ET1}Octβ3R^MB04794

v101189

v102515

v106519

v6099

w¹¹¹⁸; P{GD2952}v6099

v6100

w¹¹¹⁸; P{GD2952}v6100

v6104

w¹¹¹⁸; P{GD2953}v6104

v9068

w¹¹¹⁸; P{GD3923}v9068

v42314

w¹¹¹⁸; P{GD14918}v42314

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP08282

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0250910

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0250910

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3885573

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Octβ3R CG33959

(FlyBase Genome Annotators, 2005)

Source for database merge of

Source for merge of: Octβ3R CG18554 CG34055

(FlyBase Genome Annotators, 2008)

Source for merge of: CG31348 CG31351

(FlyBase Genome Annotators, 2005)

Additional comments

Annotations CG18554, CG33959, and CG34055 merged as CG42244 in release 5.7 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotation CG31350 split into CG33959 and CG34055 in release 4.3 of the genome annotation. In addition, release 4.3 annotation CG33959 contains sequences corresponding to release 4.2 annotations CG31348 and CG31351.

(FlyBase Genome Annotators, 2005)

Annotation CG7078 split into CG31348, CG31350 and CG31351 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3885573

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q4LBB6

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

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Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Octbeta3R_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0250910

FlyMine - An integrated database for Drosophila genomics

FBgn0250910

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3885573

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42244

modMine - A data warehouse for the modENCODE project

FBgn0250910

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0250910

DRSC - Results frm RNAi screens

FBgn0250910

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0250910

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG18554-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0250910

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG18554

CG31348

CG31350

(Bryson-Richardson et al., 2004)

CG31351

(Hauser et al., 2006, Bryson-Richardson et al., 2004)

CG33959

(FlyBase Genome Annotators, 2005)

CG34055

(Japanese National Institute of Genetics, 2012.5.21)

CG42244

(Kondo et al., 2020, Lu et al., 2016, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008)

CG7078

(Evans and Maqueira, 2005, Maqueira et al., 2005, Bettencourt and Feder, 2001, Brody and Cravchik, 2000)

DmCG7078

(Roeder et al., 2003)

DmOctβ3R

(Qi et al., 2017, Maqueira et al., 2005)

OctBeta3

(Evans, 2005.2.18, Evans, 2005.2.18, Evans, 2005.2.18, Evans, 2005.2.18)

Octb3R

(Li et al., 2015)

Octbeta3R

(Deng, 2020.1.10, Deng and Rao, 2020.1.8, Kondo et al., 2020, Texada et al., 2020, Rao and Deng, 2019.10.23, Crocker et al., 2016, Gene Disruption Project members, 2015-, Morgante et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, FlyBase Genome Annotators, 2008)

Octβ3R

(Mazzotta et al., 2020, Deng et al., 2019, Lin et al., 2019, Meltzer et al., 2019, Selcho and Pauls, 2019, Youn et al., 2018, Branch et al., 2017, Lu et al., 2016, Niwa and Niwa, 2016, El-Kholy et al., 2015, Garlapow et al., 2015, Landayan and Wolf, 2015, Lim et al., 2014, Zhang et al., 2013, Ohhara et al., 2012)

anon-WO0170980.187

anon-WO0170980.188

octRβ3

(Faisal et al., 2014)

octβ3R

(Li et al., 2017, Li et al., 2015)

Name Synonyms

CG18554

CG34055

Octbeta3R

(FlyBase Genome Annotators, 2008)

Octopamine β3 receptor

Octβ3R

octopamine receptor β3

(Faisal et al., 2014)

Secondary FlyBase IDs

FBpp0082144
FBtr0082675
FBpp0082143
FBtr0082674
FBtr0082677
FBpp0082146
FBgn0053959
FBgn0038061
FBgn0046559
FBgn0046560
FBgn0051348
FBgn0051350
FBgn0051351
FBgn0038060
FBan0031348
FBan0031351
FBan0031350
FBgn0054055

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections