FB2021_06, released December 14, 2021

Gene: Dmel\Octβ3R

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General Information
Symbol
Dmel\Octβ3R
Species
D. melanogaster
Name
Octopamine β3 receptor
Annotation Symbol
CG42244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0250910
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909). (UniProt, Q4LBB6)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

OctBeta3, DmOctβ3R

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-52
RefSeq locus
NT_033777 REGION:12511570..12548229
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables octopamine receptor activity
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables G protein-coupled amine receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
enables octopamine receptor activity
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
inferred from biological aspect of ancestor with PANTHER:PTN001206597
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from direct assay
(Maqueira et al., 2005)
involved_in G protein-coupled receptor signaling pathway
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001205212
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (Q4LBB6)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OCTOPAMINE RECEPTORS -
Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
Protein Function (UniProtKB)
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909).
(UniProt, Q4LBB6)
Summary (Interactive Fly)

G-protein coupled receptor, monoaminergic autocrine signaling, body size checkpoint, nutrient dependence of metamorphosis

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Octβ3R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.39

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Octβ3R-RF
FBtr0290334
NM_001038959
6101
1256
Octβ3R-RG
FBtr0290335
NM_141953
5687
1118
Octβ3R-RJ
FBtr0301944
NM_001038954
3668
445
Octβ3R-RK
FBtr0308597
NM_001038957
3817
456
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Octβ3R-PF
FBpp0288773
136.4
1256
6.41
NP_001034048
ABC66173
Octβ3R-PG
FBpp0288774
121.5
1118
5.64
NP_650210
AAF54832
Octβ3R-PJ
FBpp0291156
48.9
445
6.83
NP_001034043
ABC66171
Octβ3R-PK
FBpp0300821
49.4
456
7.08
NP_001034046
ABC66172
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Octβ3R using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Octβ3R in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Octβ3R
Transgenic constructs containing regulatory region of Octβ3R
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel7317
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(3R)HugattP
(Rao and Deng, 2019.10.23)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HTR4
5 of 15
Yes
No
Hsap\ADRB1
3 of 15
No
No
Hsap\ADRB2
3 of 15
No
No
2  
Hsap\ADRB3
3 of 15
No
Yes
Hsap\HRH2
2 of 15
No
Yes
1  
Hsap\DRD1
1 of 15
No
No
Hsap\DRD5
1 of 15
No
No
Hsap\GPR148
1 of 15
No
Yes
Hsap\TAAR1
1 of 15
No
Yes
Hsap\TAAR2
1 of 15
No
Yes
Hsap\TAAR3P
1 of 15
No
Yes
Hsap\TAAR5
1 of 15
No
Yes
Hsap\TAAR6
1 of 15
No
Yes
Hsap\TAAR8
1 of 15
No
Yes
Hsap\TAAR9
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Htr4
5 of 15
Yes
No
Mmus\Adrb1
3 of 15
No
No
Mmus\Adrb2
3 of 15
No
No
Mmus\Adrb3
3 of 15
No
Yes
Mmus\Hrh2
2 of 15
No
Yes
Mmus\Drd1
1 of 15
No
No
Mmus\Drd5
1 of 15
No
No
Mmus\Taar1
1 of 15
No
Yes
Mmus\Taar2
1 of 15
No
Yes
Mmus\Taar3
1 of 15
No
Yes
Mmus\Taar4
1 of 15
No
Yes
Mmus\Taar5
1 of 15
No
Yes
Mmus\Taar6
1 of 15
No
Yes
Mmus\Taar7a
1 of 15
No
Yes
Mmus\Taar7b
1 of 15
No
Yes
Mmus\Taar7d
1 of 15
No
Yes
Mmus\Taar7e
1 of 15
No
Yes
Mmus\Taar7f
1 of 15
No
Yes
Mmus\Taar8a
1 of 15
No
Yes
Mmus\Taar8b
1 of 15
No
Yes
Mmus\Taar8c
1 of 15
No
Yes
Mmus\Taar9
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (22)
Rnor\Htr4
5 of 13
Yes
No
Rnor\Adrb1
3 of 13
No
No
Rnor\Adrb2
3 of 13
No
No
Rnor\Adrb3
3 of 13
No
Yes
Rnor\Taar7h
2 of 13
No
Yes
Rnor\Drd5
1 of 13
No
No
Rnor\Hrh2
1 of 13
No
Yes
Rnor\LOC100910174
1 of 13
No
Yes
Rnor\Taar1
1 of 13
No
Yes
Rnor\Taar2
1 of 13
No
Yes
Rnor\Taar3
1 of 13
No
Yes
Rnor\Taar4
1 of 13
No
Yes
Rnor\Taar5
1 of 13
No
Yes
Rnor\Taar6
1 of 13
No
Yes
Rnor\Taar7a
1 of 13
No
Yes
Rnor\Taar7b
1 of 13
No
Yes
Rnor\Taar7d
1 of 13
No
Yes
Rnor\Taar7e
1 of 13
No
Yes
Rnor\Taar7g
1 of 13
No
Yes
Rnor\Taar8b
1 of 13
No
Yes
Rnor\Taar8c
1 of 13
No
Yes
Rnor\Taar9
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\htr4
3 of 12
Yes
Yes
Xtro\adrb1
1 of 12
No
No
Xtro\adrb2
1 of 12
No
No
Xtro\drd1c
1 of 12
No
No
Xtro\drd1
1 of 12
No
No
Xtro\drd5
1 of 12
No
No
Xtro\hrh2
1 of 12
No
Yes
Xtro\LOC100490372
1 of 12
No
No
Danio rerio (Zebrafish) (86)
Drer\adrb1
2 of 15
Yes
No
Drer\adrb2a
2 of 15
Yes
No
Drer\adrb2b
2 of 15
Yes
No
Drer\adrb3a
2 of 15
Yes
No
Drer\adrb3b
2 of 15
Yes
No
Drer\hrh2b
2 of 15
Yes
Yes
Drer\si:dkey-247m21.3
2 of 15
Yes
No
Drer\taar12a
2 of 15
Yes
Yes
Drer\taar12b
2 of 15
Yes
Yes
Drer\taar12c
2 of 15
Yes
Yes
Drer\taar12e
2 of 15
Yes
Yes
Drer\taar12f
2 of 15
Yes
Yes
Drer\taar12g
2 of 15
Yes
Yes
Drer\taar12h
2 of 15
Yes
Yes
Drer\taar12i
2 of 15
Yes
Yes
Drer\taar12j
2 of 15
Yes
Yes
Drer\taar12m
2 of 15
Yes
Yes
Drer\taar19t
2 of 15
Yes
Yes
Drer\drd1a
1 of 15
No
No
Drer\drd1b
1 of 15
No
No
Drer\drd6b
1 of 15
No
No
Drer\drd7
1 of 15
No
No
Drer\hrh2a
1 of 15
No
Yes
Drer\htr4
1 of 15
No
No
Drer\LOC563567
1 of 15
No
No
Drer\LOC567498
1 of 15
No
No
Drer\LOC100149223
1 of 15
No
Yes
Drer\si:ch211-238p8.18
1 of 15
No
Yes
Drer\si:ch211-238p8.24
1 of 15
No
Yes
Drer\si:dkey-181m19.17
1 of 15
No
Yes
Drer\taar1b
1 of 15
No
Yes
Drer\taar10a
1 of 15
No
Yes
Drer\taar10b
1 of 15
No
Yes
Drer\taar10c
1 of 15
No
Yes
Drer\taar10d
1 of 15
No
Yes
Drer\taar10
1 of 15
No
Yes
Drer\taar11
1 of 15
No
Yes
Drer\taar13a
1 of 15
No
Yes
Drer\taar13b
1 of 15
No
Yes
Drer\taar13c
1 of 15
No
Yes
Drer\taar13d
1 of 15
No
Yes
Drer\taar13e
1 of 15
No
Yes
Drer\taar14b
1 of 15
No
Yes
Drer\taar14h
1 of 15
No
Yes
Drer\taar16f
1 of 15
No
Yes
Drer\taar16g
1 of 15
No
Yes
Drer\taar17a
1 of 15
No
Yes
Drer\taar18a
1 of 15
No
Yes
Drer\taar18b
1 of 15
No
Yes
Drer\taar18c
1 of 15
No
Yes
Drer\taar18d
1 of 15
No
Yes
Drer\taar18g
1 of 15
No
Yes
Drer\taar18h
1 of 15
No
Yes
Drer\taar18i
1 of 15
No
Yes
Drer\taar18j
1 of 15
No
Yes
Drer\taar19a
1 of 15
No
Yes
Drer\taar19b
1 of 15
No
Yes
Drer\taar19c
1 of 15
No
Yes
Drer\taar19d
1 of 15
No
Yes
Drer\taar19g
1 of 15
No
Yes
Drer\taar19j
1 of 15
No
Yes
Drer\taar19k
1 of 15
No
Yes
Drer\taar19o
1 of 15
No
Yes
Drer\taar19r
1 of 15
No
Yes
Drer\taar19s
1 of 15
No
Yes
Drer\taar20a1
1 of 15
No
Yes
Drer\taar20a
1 of 15
No
Yes
Drer\taar20b1
1 of 15
No
Yes
Drer\taar20b
1 of 15
No
Yes
Drer\taar20c1
1 of 15
No
Yes
Drer\taar20c
1 of 15
No
Yes
Drer\taar20d1
1 of 15
No
Yes
Drer\taar20h
1 of 15
No
Yes
Drer\taar20i
1 of 15
No
Yes
Drer\taar20j
1 of 15
No
Yes
Drer\taar20l
1 of 15
No
Yes
Drer\taar20n
1 of 15
No
Yes
Drer\taar20o
1 of 15
No
Yes
Drer\taar20r
1 of 15
No
Yes
Drer\taar20t
1 of 15
No
Yes
Drer\taar20u
1 of 15
No
Yes
Drer\taar20v
1 of 15
No
Yes
Drer\taar20w
1 of 15
No
Yes
Drer\taar20x
1 of 15
No
Yes
Drer\taar20z
1 of 15
No
Yes
Drer\zgc:162592
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\C01F1.4
1 of 15
Yes
Yes
Cele\F59D12.1
1 of 15
Yes
No
Cele\npr-1
1 of 15
Yes
No
Cele\ser-5
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901TF )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012258
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011629
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012257
Drosophila simulans
Dsim\GD20558
Drosophila sechellia
Dsec\GM26001
Drosophila erecta
Dere\GG17116
Drosophila yakuba
Dyak\GE24505
Drosophila ananassae
Dana\GF23003
Drosophila pseudoobscura pseudoobscura
Dpse\GA26829
Drosophila persimilis
Dper\GL13572
Drosophila willistoni
Dwil\GK13570
Drosophila virilis
Dvir\GJ10602
Drosophila mojavensis
Dmoj\GI23112
Drosophila grimshawi
Dgri\GH18897
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AWD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023295
Glossina morsitans
Tsetse fly
Gmor\GMOY003496
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11899
Mayetiola destructor
Hessian fly
Mdes\Mdes002520
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDOP5
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003873
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B2C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BmOAR2.1
Bombyx mori
Silkmoth
Bmor\BGIBMGA002248
Bombyx mori
Silkmoth
Bmor\BGIBMGA002249
Bombyx mori
Silkmoth
Bmor\BGIBMGA002326
Danaus plexippus
Monarch butterfly
Dple\DPOGS205366-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200581-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209108-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002743
Heliconius melpomene
Postman butterfly
Hmel\HMEL014462
Heliconius melpomene
Postman butterfly
Hmel\HMEL009712
Apis florea
Little honeybee
Aflo\5278539204
Apis florea
Little honeybee
Aflo\3651180356
Apis florea
Little honeybee
Aflo\4501543908
Apis mellifera
Western honey bee
Amel\GB52879
Apis mellifera
Western honey bee
Amel\oa2
Apis mellifera
Western honey bee
Amel\GB52878
Apis mellifera
Western honey bee
Amel\GB49696
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21653
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11589
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11590
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11588
Bombus terrestris
Buff-tailed bumblebee
Bter\15202637
Bombus terrestris
Buff-tailed bumblebee
Bter\15207086
Bombus terrestris
Buff-tailed bumblebee
Bter\15202817
Bombus terrestris
Buff-tailed bumblebee
Bter\15207087
Linepithema humile
Argentine ant
Lhum\LH12970
Linepithema humile
Argentine ant
Lhum\LH12975
Linepithema humile
Argentine ant
Lhum\LH12976
Linepithema humile
Argentine ant
Lhum\LH20188
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00234b
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d44
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d43
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001703
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00011
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12979
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12851
Tribolium castaneum
Red flour beetle
Tcas\TC012597
Tribolium castaneum
Red flour beetle
Tcas\TC012598
Tribolium castaneum
Red flour beetle
Tcas\TC012600
Pediculus humanus
Human body louse
Phum\PHUM549550
Pediculus humanus
Human body louse
Phum\PHUM027040
Pediculus humanus
Human body louse
Phum\PHUM497230
Rhodnius prolixus
Kissing bug
Rpro\RPRC011545
Rhodnius prolixus
Kissing bug
Rpro\RPRC014610
Rhodnius prolixus
Kissing bug
Rpro\RPRC005349
Cimex lectularius
Bed bug
Clec\CLEC025394
Cimex lectularius
Bed bug
Clec\CLEC025157
Cimex lectularius
Bed bug
Clec\CLEC025161
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010025
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004658
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007386
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13825
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13827
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10946
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09X5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013184
Ixodes scapularis
Black-legged tick
Isca\ISCW008552
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60041.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60165.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g04980
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347041
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Octβ1R
3 of 10
Dop1R1
2 of 10
Dop1R2
2 of 10
Dop2R
2 of 10
DopEcR
2 of 10
Octβ2R
2 of 10
Oct-TyrR
2 of 10
TyrRII
2 of 10
TyrR
2 of 10
5-HT2B
1 of 10
CG12290
1 of 10
CG13579
1 of 10
mAChR-A
1 of 10
mAChR-B
1 of 10
mAChR-C
1 of 10
Oamb
1 of 10
Octα2R
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Human Ortholog
    Disease
    Evidence
    References
    ADRB2; adrenoceptor beta 2
    model of  obesity
    IEA
    (FlyBase, 2019-)
    ADRB3; adrenoceptor beta 3
    model of  obesity
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HTR4; 5-hydroxytryptamine receptor 4
    5 of 15
    602164
        ADRB1; adrenoceptor beta 1
        3 of 15
        109630
          ADRB2; adrenoceptor beta 2
          3 of 15
          109690
           
          ADRB3; adrenoceptor beta 3
          3 of 15
          109691
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Octβ2R
          suppressible
          Octβ3R
          (Lim et al., 2014)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-52
          Cytogenetic map
          87B15-87C1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          87B15-87C1
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-52

          (FlyBase, 2016)

          3-49.5

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (21)
          Genomic Clones (25)
          cDNA Clones (25)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Octβ3R CG33959

              (FlyBase Genome Annotators, 2005)
              Source for database merge of

              Source for merge of: Octβ3R CG18554 CG34055

              (FlyBase Genome Annotators, 2008)

              Source for merge of: CG31348 CG31351

              (FlyBase Genome Annotators, 2005)
              Additional comments

              Annotations CG18554, CG33959, and CG34055 merged as CG42244 in release 5.7 of the genome annotation.

              (FlyBase Genome Annotators, 2008)

              Annotation CG31350 split into CG33959 and CG34055 in release 4.3 of the genome annotation. In addition, release 4.3 annotation CG33959 contains sequences corresponding to release 4.2 annotations CG31348 and CG31351.

              (FlyBase Genome Annotators, 2005)

              Annotation CG7078 split into CG31348, CG31350 and CG31351 in release 3 of the genome annotation.

              (FlyBase Genome Annotators, 2002-2003)
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 45 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (20)
              Reported As
              Symbol Synonym
              CG18554
              CG31348
              CG31350
              (Bryson-Richardson et al., 2004)
              CG31351
              (Hauser et al., 2006, Bryson-Richardson et al., 2004)
              CG33959
              (FlyBase Genome Annotators, 2005)
              CG34055
              (Japanese National Institute of Genetics, 2012.5.21)
              CG42244
              (Ward and Moehring, 2021, Kondo et al., 2020, Lu et al., 2016, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008)
              CG7078
              (Evans and Maqueira, 2005, Maqueira et al., 2005, Bettencourt and Feder, 2001, Brody and Cravchik, 2000)
              DmCG7078
              (Roeder et al., 2003)
              DmOctβ3R
              (Qi et al., 2017, Maqueira et al., 2005)
              OctBeta3
              (Evans, 2005.2.18, Evans, 2005.2.18, Evans, 2005.2.18, Evans, 2005.2.18)
              Octb3R
              (Li et al., 2015)
              Octbeta3R
              (Deng, 2020.1.10, Deng and Rao, 2020.1.8, Kondo et al., 2020, Texada et al., 2020, Rao and Deng, 2019.10.23, Crocker et al., 2016, Gene Disruption Project members, 2015-, Morgante et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, FlyBase Genome Annotators, 2008)
              Octβ3R
              (Chen et al., 2021, McLaughlin et al., 2021, Sood et al., 2021, Ward and Moehring, 2021, Mazzotta et al., 2020, Pan et al., 2020, Roeder, 2020, Deng et al., 2019, Lin et al., 2019, Meltzer et al., 2019, Selcho and Pauls, 2019, Youn et al., 2018, Branch et al., 2017, Lu et al., 2016, Niwa and Niwa, 2016, El-Kholy et al., 2015, Garlapow et al., 2015, Landayan and Wolf, 2015, Lim et al., 2014, Zhang et al., 2013, Ohhara et al., 2012)
              anon-WO0170980.187
              anon-WO0170980.188
              octRβ3
              (Faisal et al., 2014)
              octβ3R
              (Li et al., 2017, Li et al., 2015)
              Name Synonyms
              CG18554
              CG34055
              Octbeta3R
              (FlyBase Genome Annotators, 2008)
              Octopamine β3 receptor
              Octβ3R
              octopamine receptor β3
              (Faisal et al., 2014)
              Secondary FlyBase IDs
              • FBpp0082144
              • FBtr0082675
              • FBpp0082143
              • FBtr0082674
              • FBtr0082677
              • FBpp0082146
              • FBgn0053959
              • FBgn0038061
              • FBgn0046559
              • FBgn0046560
              • FBgn0051348
              • FBgn0051350
              • FBgn0051351
              • FBgn0038060
              • FBan0031348
              • FBan0031351
              • FBan0031350
              • FBgn0054055
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (87)