• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\futsch

General Information
Symbol	Dmel\futsch	Species	D. melanogaster
Name	futsch	Annotation symbol	CG34387
Feature type	protein_coding_gene	FlyBase ID	FBgn0259108
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	22C10, mAb22C10, mAb 22C10, MAP1B, EG:49E4.1, CG3064, olk
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2A3-2A3	Sequence location	X:1,303,102..1,345,400 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene futsch is referred to in FlyBase by the symbol Dmel\futsch (CG34387, FBgn0259108). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule binding. There is experimental evidence that it is involved in the biological process: olfactory learning; neurofilament cytoskeleton organization; negative regulation of neuron apoptosis; dendrite morphogenesis; microtubule cytoskeleton organization; axonogenesis; axon cargo transport; regulation of synaptic growth at neuromuscular junction. 18 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; anatomical structure; synapse; cell part; cytoplasmic part; organelle; axon; neuromuscular junction; peripheral nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein of unknown function DUF1213. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. Gene sequence location is X:1303102..1345400.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264 Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 Du et al., 2010, Hum. Mol. Genet. 19(10): 1883--1896
FB2012_01	References Powell et al., 2004, Molec. Cell. Biol. 24(21): 9517--9526 Lundell et al., 1996, Molec. Cell. Neurosci. 7(1): 46--61 Albornoz et al., 2008, Gene Expr. Patterns 8(6): 443--451 Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Sequence features HFA17950 HFA17949 BKN34414 HFA17688 BKN21281 HFA17952 BKN31099 HFA18543
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2A3-2A3   Limits computationally determined from genome sequence between P{EP}futschEP1419 and P{EP}brEP1515
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1F-2A     (Hummel et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\futsch for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on protein alignment (BLASTX) data. DGC SD17959 clone appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) futsch-RC FBtr0112628  NM_001103394   19300   5495 futsch-RE FBtr0307597     19936   5495 futsch-RF FBtr0307598     20736   5495
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein futsch-PC   FBpp0111540   592.1   5495   4.61     NP_001096864   ABW09325 futsch-PE   FBpp0300235   592.1   5495   4.61       futsch-PF   FBpp0300236   592.1   5495   4.61
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1213 (IPR009603)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 ABW09325   AI106828   AI389853   AI514120   AL031128 CAA20006   AQ025455   AY070846   BG632155   BG632276   BG633447   BI636317   BT030436   BT030858   CK135981   CO265518   CO265573   CO275881   CO282580   CO284388   CO285367   CO295234   CO301272   CO305713   CO307383   CO309066   EC062367   EC074220   EC084305   EC088985   EC198926   EC208844   EC210930   EC222749   EC233369   EC234685   EC237300   EC247543   EC249630   EL887343   EL887383   EL887421   EW712977   GO271138
UniProtKB/Swiss-Prot	Q9W596
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   dMP2 neuron   (Hummel et al., 2000) vMP2 neuron   (Hummel et al., 2000) embryonic stage 13 -- 16   VUM neuron   • axon & neuronal cell body (Hummel et al., 2000) aCC neuron   • axon & neuronal cell body (Hummel et al., 2000) embryonic stage 13 -- 17   lch5 neuron   (Kraut and Zinn, 2004) scolopidial neuron of mesothoracic dorsal triscolopidial chordotonal organ dch3   (Kraut and Zinn, 2004) scolopidial neuron of metathoracic dorsal triscolopidial chordotonal organ dch3   (Kraut and Zinn, 2004) embryonic stage 14   presumptive embryonic/larval central nervous system   (Ozon et al., 2002) embryonic stage 14 -- 17   aCC neuron   (O'Connor-Giles and Skeath, 2003) sensory neuron   • axon & dendrite & neuronal cell body (Hummel et al., 2000) embryonic stage 15   scolopidial neuron   (Kaminker et al., 2001) embryonic stage 15 -- 16   chordotonal organ   (Kurant et al., 2001) late third instar larval stage   photoreceptor cell   • axon & dendrite & neuronal cell body (Hummel et al., 2000) Bolwig nerve   • axon & dendrite & neuronal cell body (Hummel et al., 2000) inferred from author statements Stage Tissue/Position (including subcellular localization) Reference embryonic stage   MP1 neuron   (Mellerick and Modica, 2002) aCC neuron   (Mellerick and Modica, 2002) SP1 neuron   (Mellerick and Modica, 2002) vMP2 neuron   (Mellerick and Modica, 2002) VUM neuron   (Mellerick and Modica, 2002) RP2 neuron   (Mellerick and Modica, 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	The earliest expression of futsch protein is at embryonic stage 11, in the vMP2 and dMP2 interneurons. (Hummel et al., 2000)
Marker for
	neuron <of> peripheral nervous system sensory neuron scolopidial neuron aCC neuron
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259108    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259108 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259108 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr  (164) embryo 14-16hr  (211) embryo 16-18hr  (226) embryo 18-20hr  (237) embryo 20-22hr  (291) embryo 22-24hr  (330) larva L1  (424) larva L2  (230) larva L3 12hr old  (147) larva L3 puffstage 1-2    54 larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  (120) white prepupae new  (118) white prepupae 12hr  (326) white prepupae 24hr  (649) pupae 2d postWPP  (1125) pupae 3d postWPP  (381) pupae 4d postWPP  (289) adult male 01day  (661) adult male 05day  (662) adult male 30day  (521) adult female 01day  (239) adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259108 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr  (164) embryo 14-16hr  (211) embryo 16-18hr  (226) embryo 18-20hr  (237) embryo 20-22hr  (291) embryo 22-24hr  (330) larva L1  (424) larva L2  (230) larva L3 12hr old  (147) larva L3 puffstage 1-2    54 larva L3 puffstage 3-6  (151) larva L3 puffstage 7-9  120 white prepupae new  118 white prepupae 12hr  (326) white prepupae 24hr  (649) pupae 2d postWPP  (1125) pupae 3d postWPP  (381) pupae 4d postWPP  (289) adult male 01day  (661) adult male 05day  (662) adult male 30day  (521) adult female 01day  (239) adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    15 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    39 embryo 10-12hr    31 embryo 12-14hr    164 embryo 14-16hr    211 embryo 16-18hr    226 embryo 18-20hr    237 embryo 20-22hr    291 embryo 22-24hr    330 larva L1    424 larva L2    230 larva L3 12hr old    147 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    151 larva L3 puffstage 7-9    120 white prepupae new    118 white prepupae 12hr    326 white prepupae 24hr    649 pupae 2d postWPP    1125 pupae 3d postWPP    381 pupae 4d postWPP    289 adult male 01day    661 adult male 05day    662 adult male 30day    521 adult female 01day    239 adult female 05day    85 adult female 30day    92 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259108    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259108 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259108 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14772-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal futschP158 lethal | recessive futschPG97 viable futschK68 viable, with Scer\GAL4pnr-MD237 futschGD1263 Sterility Allele male fertile futschN94 Other Phenotypes Allele increased cell death | adult stage futscholk1 learning defective | adult stage futscholk1 futscholk3 neuroanatomy defective futschN94 neuroanatomy defective, with Scer\GAL4elav-C155 futschEP1419 neuroanatomy defective | larval stage futschK68 neuroanatomy defective | recessive futschK68 futschN94 neurophysiology defective futschN94 neurophysiology defective, with Scer\GAL4elav-C155 futschEP1419 smell perception defective | adult stage futscholk1 Phenotype manifest in Allele abdominal posterior fascicle neuron futschP158 antennal lobe futscholk1 axon futschP158 axon, with Scer\GAL4sim.PS futschEP1419 bouton futschK68 futschN94 bouton, with Scer\GAL4elav-C155 futschEP1419 longitudinal connective futschP158 microtubule & antennal lobe futscholk1 mitochondrion futschN94 mitochondrion & neuron futscholk1 motor neuron futschP158 mushroom body calyx futscholk1 neuromuscular junction futschN94 neuromuscular junction, with Scer\GAL4elav-C155 futschEP1419 neuropil futscholk1 photoreceptor cell futschN94 photoreceptor cell, with Scer\GAL4elav-C155 futschEP1419 protocerebrum futscholk1 sensory nerve & dendrite futschP158 synapse futschK68 futschN94 synapse, with Scer\GAL4elav-C155 futschEP1419 synapse & microtubule futschK68 futschN94
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of futsch Class Mutagen Stocks Known lesion futschEP1419 P-element activity 1 Yes futschf03697 1 -- futschK68 hypomorphic allele - genetic evidence 1 -- futschMB09452 1 -- futschN94 hypomorphic allele - genetic evidence 1 -- futschP158 amorphic allele - genetic evidence 0 -- futschEC2 0 -- futschM455 0 -- futscholk1 0 Yes futscholk2 hypomorphic allele - genetic evidence 0 -- futscholk3 hypomorphic allele - genetic evidence 0 -- futschP28 0 -- futschPG97 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of futsch Class Mutagen Stocks Known lesion futschGD1263 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes futschGD8438 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes futschNterm.Scer\UAS in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes futschΔN-term.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes futschΔN-term.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)A94 (Hummel et al., 2000) Df(1)AC7 (Hummel et al., 2000) Df(1)AD11 (Zou et al., 2008) Df(1)Exel6227 (Ryder, 2004.4.26) Df(1)RH4 (Hummel et al., 2000) Df(1)S39 (Hummel et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1263} NA P{GD8438} NA P{UAS-Nterm.futsch} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}futschEP1419 NA miscellaneous insertions P{SUPor-P}KG03606 NA PBac{WH}futschf03697 NA insertion of enhancer trap binary system Mi{ET1}futschMB09452 No P{GawB}futschPG97 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from direct assay (Roos et al., 2000) inferred from direct assay AND inferred from sequence or structural similarity with UniProtKB:P46821 (Hummel et al., 2000) protein binding inferred from physical interaction with Fmr1 (Zhang et al., 2001)
Biological Process
CV term Evidence References
axon cargo transport inferred from mutant phenotype (da Cruz et al., 2005) axonogenesis inferred from mutant phenotype (Hummel et al., 2000) dendrite morphogenesis inferred from mutant phenotype (Hummel et al., 2000) microtubule cytoskeleton organization inferred from mutant phenotype (Roos et al., 2000) negative regulation of neuron apoptosis inferred from mutant phenotype (da Cruz et al., 2005) neurofilament cytoskeleton organization inferred from mutant phenotype (da Cruz et al., 2005) olfactory learning inferred from mutant phenotype (da Cruz et al., 2005) regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Franco et al., 2004, Roos et al., 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hummel et al., 2000, Roos et al., 2000) microtubule cytoskeleton inferred from direct assay (Hummel et al., 2000)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000, EDGP Project Members, 1994-)
Biological Process
CV term Evidence References
compound eye development non-traceable author statement (Oostra, 2002) microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) nervous system development non-traceable author statement (Oostra, 2002) neuromuscular junction development non-traceable author statement (Oostra, 2002)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000, EDGP Project Members, 1994-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene (da Cruz et al., 2005)
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions futsch allele Gene References futschN94 Fmr1 (Zhang et al., 2001) unspecified flexin (Roos et al., 2000) Fmr1 (da Cruz et al., 2005) tau (da Cruz et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 625175 DroID - A comprehensive database of gene and protein interactions. • FBgn0259108 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 5740544
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dere\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dore\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dpse\GA13235   Dpse\GA15901   Dsim\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dtei\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dyak\futsch (Ko et al., 2006)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009847-PA Aedes aegypti (mosquito) AGAP001194-PA Anopheles gambiae (mosquito) XP_001121015.1 Apis mellifera (honey bee) XP_001946082.1 Acyrthosiphon pisum (pea aphid) CPIJ013059 Culex pipens (mosquito) 100635 Daphnia pulex (daphnia) ENSECAP00000020152 Equus caballus (horse) ENSGACP00000023072 Gymnopilus aculeatus (mushroom) ENSP00000371462 Homo sapiens (human) ENSMODP00000022190 Monodelphis domestica (gray opossum) ENSMMUP00000009512 Macaca mulatta (rhesus monkey) ENSMUSP00000092223 Mus musculus (house mouse) XP_001607160.1 Nasonia vitripennis (wasp) ENSORLP00000001988 Oryzias latipes (japanese killifish) ENSPPYP00000007268 Pongo pygmaeus (orangutan) ENSPTRP00000051562 Pan troglodytes (chimpanzee) ENSRNOP00000019320 Rattus norvegicus (norway rat) Smp_166030 Schistosoma mansoni (trematode parasite) XP_780581.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972911.2 Tribolium castaneum (red flour beetle) ENSTRUP00000047194 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10254 LH16726 ISCW009767 FBgn0234184 FBgn0218856 FBgn0218280 FBgn0202426 FBgn0151857 FBgn0138447 FBgn0052602 FBgn0050069 FBgn0036181 FBgn0132337 FBgn0085870 FBgn0098021 FBgn0089073 CPIJ013059 CPIJ007483 BGIBMGA007208 ACYPI000252 GB11509 AGAP001194 AAEL009847 PB22501 PHUM399550 GLEAN_01001
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	8794 y1 futschK68 8805 y1 futschN94 10751 P{EP}futschEP1419 w1118 27783 Mi{ET1}futschMB09452 w1118
Harvard	- PBac{WH}futschf03697
VDRC	v6972 w1118; P{GD1263}v6972 v6973 w1118; P{GD1263}v6973
Genomic Clones ( 2 )
	BACR09H15 BACR30G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH26828
Other clones	IP18437 IP18737
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04292 GH21135
Other clones	32927 32991 33555 44961 51503 52753 57983 58215 79379 108348 149065 156748 CK01.142B.A12 DMG1-chrX.2.035.a DMG7-chrX.3.004.pred.a.3prime EK119034 EK142845 EK143048 EK160750 EK165941 EK168839 EK180619 EK208964 EK249304 EK254456 EK260044 GH06062 GH27181 IP18537 IP18637 SD17959
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259108 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31091 44443 5740544
Antibody Information
	polyclonal (Zou et al., 2008, Gogel et al., 2006)
Other Information
Discoverer
Etymology
	futsch is German for "gone". (Hummel et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: EG:49E4.1 CG3064 (Bayraktaroglu, 2000.4.7) Source for merge of: futsch CG14772 (FlyBase Genome Annotators, 2007) Source for merge of: futsch EG:49E4.1 (Gatt, 2000.11.14) Source for merge of: futsch olk (da Cruz et al., 2005)
Additional comments	Annotations CG3064 and CG14772 merged as CG34387 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Either loss or overexpression of Fmr1 or futsch have identical effects on synaptic transmission - elevation at the NMJ and suppression in photoreceptor cells. (Zhang et al., 2001) futsch is necessary for dendritic and axonal growth. (Hummel et al., 2000) futsch may control synaptic growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. (Roos et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103394 RefSeq (Proteins) • NP_001096864 DDBJ / EMBL / GenBank • AAF45622 ABW09325 AI389853 AL031128 AQ025455 BI636317 CAA20006 Entrez Gene - A searchable database of RefSeq genes. • 5740544 UniProtKB/Swiss-Prot • Q9W596
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1213 (IPR009603)
Linkouts
	BioGRID - A database of protein and genetic interactions • 625175 DroID - A comprehensive database of gene and protein interactions. • FBgn0259108 DRSC - Results from RNAi screens. • FBgn0259108 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259108 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14772-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259108 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31091 44443 5740544 InParanoid A subset of ortholog calls from InParanoid. • AAEL009847-PA Aedes aegypti (mosquito) AGAP001194-PA Anopheles gambiae (mosquito) XP_001121015.1 Apis mellifera (honey bee) XP_001946082.1 Acyrthosiphon pisum (pea aphid) CPIJ013059 Culex pipens (mosquito) 100635 Daphnia pulex (daphnia) ENSECAP00000020152 Equus caballus (horse) ENSGACP00000023072 Gymnopilus aculeatus (mushroom) ENSP00000371462 Homo sapiens (human) ENSMODP00000022190 Monodelphis domestica (gray opossum) ENSMMUP00000009512 Macaca mulatta (rhesus monkey) ENSMUSP00000092223 Mus musculus (house mouse) XP_001607160.1 Nasonia vitripennis (wasp) ENSORLP00000001988 Oryzias latipes (japanese killifish) ENSPPYP00000007268 Pongo pygmaeus (orangutan) ENSPTRP00000051562 Pan troglodytes (chimpanzee) ENSRNOP00000019320 Rattus norvegicus (norway rat) Smp_166030 Schistosoma mansoni (trematode parasite) XP_780581.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972911.2 Tribolium castaneum (red flour beetle) ENSTRUP00000047194 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/futsch1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 5740544 modMine - Data generated by the modENCODE project. • FBgn0259108 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10254 LH16726 ISCW009767 FBgn0234184 FBgn0218856 FBgn0218280 FBgn0202426 FBgn0151857 FBgn0138447 FBgn0052602 FBgn0050069 FBgn0036181 FBgn0132337 FBgn0085870 FBgn0098021 FBgn0089073 CPIJ013059 CPIJ007483 BGIBMGA007208 ACYPI000252 GB11509 AGAP001194 AAEL009847 PB22501 PHUM399550 GLEAN_01001
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	22C10 (Liu et al., 2009, Mehnert et al., 2007, McDonald et al., 2003, Hebbar and Fernandes, 2004, Dulcis et al., 2005, Ashley et al., 2005, Fischler et al., 2007, Dutta et al., 2005, Singh et al., 2006, Sweeney et al., 2006, Sanchez, 2006, Sanchez et al., 2006, Beronja et al., 2005, Yamamoto, 2006, Rogers et al., 2005, Acar et al., 2006, Wheeler et al., 2006, Ataman, 2006, Park et al., 2006, Sengupta, 2006, Chu-LaGraff et al., 2007, Fernandes and Krishan, 2007, Sterling et al., 2007, Bessa and Casares, 2005, Sanchez-Soriano et al., 2005, Wildonger and Mann, 2005, Monier et al., 2005, Schubiger et al., 2005, Coulson et al., 2005, Read et al., 2005, Yano et al., 2005, Singh et al., 2005, Mizutani et al., 2005, Bhalerao et al., 2005, Escudero et al., 2005, Mace and Tugores, 2004, Gong et al., 2004, Usui-Ishihara and Simpson, 2005, Pielage et al., 2004, Read et al., 2004, Kinrade and Hidalgo, 2004, Bhat, 2005, Lee et al., 2005, Grabbe et al., 2004, Niwa et al., 2004, Islam et al., 2004, Mellerick and Modica, 2002, Andrenacci et al., 2004, Schmid et al., 2002, Domingos et al., 2004, Langlais et al., 2004, Koh et al., 2004, Beck et al., 2004, Singh and Choi, 2003, Artero et al., 2003, Han et al., 2003, Yamada et al., 2003, Schenck et al., 2003, Yang et al., 2003, Sepp and Auld, 2003, Weng et al., 2003, Reim et al., 2003, Villa-Cuesta et al., 2003, Inbal et al., 2003, Koelzer and Klein, 2003, Shandala et al., 2003, Xu et al., 2002, Kambris et al., 2002, Grueber et al., 2003, Song et al., 2002, Moore et al., 2002, Song et al., 2002, Dubruille et al., 2002, Wang et al., 2002, Packard et al., 2002, Uhler et al., 2002, Dumstrei et al., 2002, Rusten et al., 2002, Soustelle et al., 2002, Terman et al., 2002, Eaton et al., 2002, Schenkel et al., 2002, Hardiman et al., 2002, Goberdhan and Wilson, 2002, Sweeney et al., 2002, Umesono et al., 2002, Tekotte et al., 2002, Marques et al., 2002, Ozon et al., 2002, Jhaveri and Rodrigues, 2002, Bulgheresi et al., 2001, Murawsky et al., 2001, Kumar et al., 2001, Ramain et al., 2001, Inbal et al., 2001, Sepp et al., 2001, Quinn et al., 2001, Badenhorst, 2001, Mehta and Bhat, 2001, Jones, 2001, Alonso et al., 2001, Schimmelpfeng et al., 2001, Adachi et al., 2001, Kammermeier et al., 2001, Vandaele et al., 2001, Kataoka et al., 2001, Koizumi et al., 2001, Plaza et al., 2001, Rusten et al., 2001, Ben-Yaacov et al., 2001, Quinn et al., 2000, Geng et al., 2000, Yeh et al., 2000, Usui-Ishihara et al., 2000, Nolo et al., 2000, Hiramoto et al., 2000, Chen and Rebay, 2000, Brown and Castelli-Gair Hombria, 2000, Connell-Crowley, 2000, Schmucker et al., 2000, Ishimoto et al., 2000, Bour et al., 2000, Aguilera et al., 2000, White and Jarman, 2000, Hoyle et al., 2000, Kuang et al., 2000, Eberl et al., 2000, Kurant and Salzberg, 2000, Schubiger and Truman, 2000, Lai et al., 2000, Justice et al., 1999, Irion and Leptin, 1999, Bhat et al., 2000, Lilly et al., 1999, Lear et al., 1999, Helms et al., 1999, Gao et al., 1999, Byars et al., 1999, Auld, 1999, Ashraf et al., 1999, Madden et al., 1999, Merianda et al., 2005, Layalle et al., 2005, Melcher and Pankratz, 2005, With et al., 2003, Grillenzoni et al., 2007, Holohan et al., 2006, Guntur and Lundell, 2008, Liu et al., 2007, Davis et al., 2005, Mellerick and Liu, 2004, Li-Kroeger et al., 2008, Bhat, 2007, Ratnaparkhi and Zinn, 2007, Le Gall et al., 2008, Taylor and Adler, 2008, Crozatier and Vincent, 2008, Lundell et al., 1996, Cornbrooks et al., 2007, Chang et al., 2006, Erclik et al., 2008, Sevrioukov et al., 2007, Górska-Andrzejak et al., 2009, Powell et al., 2004, Verstreken et al., 2005, zur Lage et al., 2004, Buch et al., 2008, Beramendi et al., 2007, Ahantarig et al., 2009, Kamikouchi et al., 2006, Hoehne et al., 2005, Udolph et al., 2009, Chang and Min, 2009, Kristiansen et al., 2005, Sokol et al., 2008, Sehadova et al., 2009, Pereira et al., 2006, Schneider and Baumgartner, 2008, Sato et al., 2010, Kain et al., 2008, Zou et al., 2008, Rajendra et al., 2007, Klein et al., 2010, Kopytova et al., 2006, Kim et al., 2007, Lee et al., 2010, Billeter et al., 2006, zur Lage and Jarman, 2010, Herr et al., 2010, Michaud and Tanguay, 2003, Llorens et al., 2007, Orian et al., 2007, Wang et al., 2011, Matsubara et al., 2011, Yamasaki et al., 2011) 22c10 (Momota et al., 2011, Griffiths and Hidalgo, 2004, Ragone et al., 2003, Yeh et al., 2001, Durand et al., 2001, Taniguchi et al., 2000, Hidalgo and Booth, 2000, Booth et al., 2000) 22C10/FUTSCH (Sedaghat et al., 2002) 22C20 (Bennett et al., 2008) CG3064 (Benos, 2000.12.13, Goldstein and Gunawardena, 2000, ) CG14772   CG34387 (FlyBase Genome Annotators, 2007) EG:49E4.1 (Bolshakov et al., 2002, Benos et al., 2001, Benos, 2000.12.13, Gatt, 2000.11.14, Hummel et al., 2000, ) Futch (Neely et al., 2010) futsch (Kurshan et al., 2009, Gogel et al., 2006, Bao et al., 2007, Sweeney et al., 2006, Bossing and Brand, 2006, Denman, 2006, Wheeler et al., 2006, Ko et al., 2006, Wiggin et al., 2005, Ashley et al., 2005, da Cruz et al., 2005, Franco et al., 2004, Monzo et al., 2006, Schimmelpfeng et al., 2006, Davis et al., 2005, Marques, 2005, Viquez et al., 2006, Pielage et al., 2008, Koch et al., 2008, Miech et al., 2008, Zou et al., 2008, Sanyal, 2009, Lee et al., 2010, Cachero et al., 2011, Wasbrough et al., 2010, Freeman et al., 2011, Nishimura et al., 2008) Futsch (Forni et al., 2004, Mehnert et al., 2007, Strigini et al., 2006, Ratnaparkhi et al., 2008, Stork et al., 2008, Elliott et al., 2005, Kracklauer et al., 2007, Gao and Bogert, 2003, Wang et al., 2007, Besse et al., 2007, Wheeler et al., 2008, Pawson et al., 2008, Lim and Kraut, 2009, Lee et al., 2008, Bennett et al., 2008, Palgi et al., 2009, Siebert et al., 2009, Lin et al., 2009, Hoehne et al., 2005, Jin et al., 2009, Viquez et al., 2009, Sharma and Nirenberg, 2007, Simon et al., 2009, Klein et al., 2010, Ellis et al., 2010, Nishimura et al., 2008, Schulte et al., 2010, Cheng et al., 2010, Melicharek et al., 2010, Nagai et al., 2010, Jinushi-Nakao et al., 2007, Albornoz et al., 2008, Du et al., 2010) mAb22C10 (Yasunaga et al., 2006, Harris and Whitington, 2001, Kraut and Zinn, 2004, Sen et al., 2004, Parsons et al., 2003, Jang et al., 2003, Sen et al., 2003, Suh et al., 2002, Chang et al., 2001, Kaminker et al., 2001, Takizawa and Hotta, 2001, Lukacsovich et al., 2001, Usui-Aoki et al., 2000, Jhaveri et al., 2000, Cheah et al., 2000, Senti et al., 2000, Goulding et al., 2000, Goulding et al., 2000, Newsome et al., 2000, Wan et al., 2000, Schock et al., 1999, Baker et al., 1992) mAb 22C10 (Ivanov et al., 2004, Escudero et al., 2003, Llimargas, 2000, Hummel et al., 2000, Genova et al., 2000, Lee et al., 2000, Greenwood and Struhl, 1999, Garcia-Alonso, 1999, Sawamoto et al., 1999, Staudt et al., 2006, Schulte et al., 2010) MAb22C10 (Lai and Orgogozo, 2004, zur Lage et al., 2003, Huang et al., 2000, Nassif et al., 1998, O'Farrell and Kylsten, 2008) Mab22C10 (Rau et al., 2001, Mozer, 2001, Awasaki and Kimura, 2001, Boulton et al., 2000, Matthews and Crews, 1999, Alone et al., 2005) mAb-22C10 (Dettman et al., 2001) Mab 22C10 (Kurant et al., 2001) mAb22c10 (Acevedo et al., 2007) Mab22c10 (Gonzalez-Gaitan and Jackle, 2000) MAP1B (Moine and Mandel, 2001, Toda et al., 2008, Lee et al., 2008, Xiong et al., 2010, Du et al., 2010) map1b (Sohn, 2001) MAP-IB (Merianda et al., 2005) olk (da Cruz et al., 2005) Olk (Herranz et al., 2010) ssC10 (Giesen et al., 2003)
Name Synonym	CG14772   Futsch (Forni et al., 2004, Strigini et al., 2006, Rogers et al., 2005, Ataman et al., 2006, Medina et al., 2006, Kretzschmar et al., 2005, Wang et al., 2007, Beuchle et al., 2007, Mellerick and Liu, 2004, Bury et al., 2008, Beramendi et al., 2007, Pack-Chung et al., 2007, Viquez et al., 2009, Simon et al., 2009, Klein et al., 2010, Adolph et al., 2009, Mosca and Schwarz, 2010, Boerner and Duch, 2010, Xiong et al., 2010, Kuzina et al., 2011, Rossetto et al., 2011) futsch (Gogel et al., 2006, Bao et al., 2007, Hummel et al., 2000, Martinek et al., 2008, Gatto and Broadie, 2008, Cachero et al., 2011) omb-like (da Cruz et al., 2005)
Secondary FlyBase IDs
	FBgn0015390 FBgn0025392 FBgn0029577 FBgn0029578 FBgn0085416 FBgn0243483
References ( 411 )
Generate a list of	All references relating to this gene ( 411 )
List References by type	Research paper  ( 336 ) Supplementary material  ( 15 ) Review  ( 27 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 13 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 25 )
	Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Freeman et al., 2011, Mol. Cell. Neurosci. 46(2): 535--547 NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. [FBrf0212894] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Momota et al., 2011, Matrix Biol. 30(4): 258--266 Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. [FBrf0213898] Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. [FBrf0216330] Wang et al., 2011, Int. J. Dev. Biol. 55(2): 223--227 Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1. [FBrf0213886] Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. [FBrf0214536] Boerner and Duch, 2010, J. Comp. Neurol. 518(13): 2437--2455 Average shape standard atlas for the adult Drosophila ventral nerve cord. [FBrf0210897] Cheng et al., 2010, Neuron 67(3): 373--380 The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion. [FBrf0211468] Du et al., 2010, Hum. Mol. Genet. 19(10): 1883--1896 Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. [FBrf0210700] Ellis et al., 2010, Dev. Biol. 342(2): 121--133 Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction. [FBrf0210828] Herr et al., 2010, Dev. Biol. 344(1): 36--51 Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. [FBrf0211319] Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264 Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome. [FBrf0216346] Klein et al., 2010, Dev. Biol. 337(2): 458--470 The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe. [FBrf0209777] Lee et al., 2010, PLoS ONE 5(6): e11012 Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. [FBrf0210994] Lee et al., 2010, J. Neurosci. 30(50): 16959--16969 LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. [FBrf0212570] Melicharek et al., 2010, Hum. Mol. Genet. 19(21): 4253--4264 Kismet/CHD7 regulates axon morphology, memory and locomotion in a Drosophila model of CHARGE syndrome. [FBrf0212001] Mosca and Schwarz, 2010, Nat. Neurosci. 13(8): 935--943 The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. [FBrf0211361] Nagai et al., 2010, Exp. Cell Res. 316(14): 2313--2321 Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. [FBrf0211294] Neely et al., 2010, Cell 143(4): 628--638 A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene. [FBrf0212295] Sato et al., 2010, Genes Cells 15(5): 485--500 Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity. [FBrf0211000] Schulte et al., 2010, J. Neurosci. 30(15): 5189--5203 DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. [FBrf0210612] Xiong et al., 2010, J. Cell Biol. 191(1): 211--223 Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. [FBrf0211939] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...