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Gene Dmel\futsch

General Information
Symbol	Dmel\futsch	Species	D. melanogaster
Name	futsch	Annotation symbol	CG34387
Feature type	protein_coding_gene	FlyBase ID	FBgn0259108
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	22C10, mAb22C10, mAb 22C10, MAP1B, EG:49E4.1, CG3064, olk
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2A3-2A3	Sequence location	X:1,303,102..1,345,400 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene futsch is referred to in FlyBase by the symbol Dmel\futsch (CG34387, FBgn0259108). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule binding. There is experimental evidence that it is involved in the biological process: olfactory learning; neurofilament cytoskeleton organization; negative regulation of neuron apoptotic process; dendrite morphogenesis; microtubule cytoskeleton organization; axonogenesis; axon cargo transport; regulation of synaptic growth at neuromuscular junction. 23 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; anatomical structure; synapse; cell part; cytoplasmic part; organelle; axon; neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Microtubule associated protein 1; Microtubule associated protein Futsch. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. Gene sequence location is X:1303102..1345400.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms hydrolase activity
FB2013_02	Controlled Vocabulary Terms microtubule
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2A3-2A3   Limits computationally determined from genome sequence between P{EP}futschEP1419 and P{EP}brEP1515
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1F-2A     (Hummel et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\futsch for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on protein alignment (BLASTX) data. DGC SD17959 clone appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) futsch-RC FBtr0112628  NM_001103394   19300   5495 futsch-RE FBtr0307597  NM_001169161   19936   5495 futsch-RF FBtr0307598  NM_001258532   20736   5495
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein futsch-PC   FBpp0111540   592.1   5495   4.61     NP_001096864   ABW09325 futsch-PE   FBpp0300235   592.1   5495   4.61     NP_001162632   AAF45622 futsch-PF   FBpp0300236   592.1   5495   4.61     NP_001245461   AFH07176
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Microtubule associated protein Futsch (IPR009603) Beta-lactamase-like (IPR001279) Microtubule associated protein 1 (IPR026074)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45622   AE014298 ABW09325   AE014298 AFH07176   AI106828   AI389853   AI514120   AL031128 CAA20006   AQ025455   AY070846   BG632155   BG632276   BG633447   BI636317   BT030436   BT030858   CK135981   CO265518   CO265573   CO275881   CO282580   CO284388   CO285367   CO295234   CO301272   CO305713   CO307383   CO309066   EC062367   EC074220   EC084305   EC088985   EC198926   EC208844   EC210930   EC222749   EC233369   EC234685   EC237300   EC247543   EC249630   EL887343   EL887383   EL887421   EW712977   GO271138
UniProtKB/Swiss-Prot	Q9W596
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   dMP2 neuron   (Hummel et al., 2000) vMP2 neuron   (Hummel et al., 2000) embryonic stage 13 -- 16   VUM neuron   • axon & neuronal cell body (Hummel et al., 2000) aCC neuron   • axon & neuronal cell body (Hummel et al., 2000) embryonic stage 13 -- 17   lch5 neuron   (Kraut and Zinn, 2004) scolopidial neuron of mesothoracic dorsal triscolopidial chordotonal organ dch3   (Kraut and Zinn, 2004) scolopidial neuron of metathoracic dorsal triscolopidial chordotonal organ dch3   (Kraut and Zinn, 2004) embryonic stage 14   presumptive embryonic/larval central nervous system   (Ozon et al., 2002) embryonic stage 14 -- 17   aCC neuron   (O'Connor-Giles and Skeath, 2003) sensory neuron   • axon & dendrite & neuronal cell body (Hummel et al., 2000) embryonic stage 15   scolopidial neuron   (Kaminker et al., 2001) embryonic stage 15 -- 16   chordotonal organ   (Kurant et al., 2001) late third instar larval stage   photoreceptor cell   • axon & dendrite & neuronal cell body (Hummel et al., 2000) Bolwig nerve   • axon & dendrite & neuronal cell body (Hummel et al., 2000) inferred from author statements Stage Tissue/Position (including subcellular localization) Reference embryonic stage   MP1 neuron   (Mellerick and Modica, 2002) aCC neuron   (Mellerick and Modica, 2002) SP1 neuron   (Mellerick and Modica, 2002) vMP2 neuron   (Mellerick and Modica, 2002) VUM neuron   (Mellerick and Modica, 2002) RP2 motor neuron   (Mellerick and Modica, 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	The earliest expression of futsch protein is at embryonic stage 11, in the vMP2 and dMP2 interneurons. (Hummel et al., 2000)
Marker for
	neuron <of> peripheral nervous system sensory neuron scolopidial neuron aCC neuron
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hummel et al., 2000, Roos et al., 2000) microtubule cytoskeleton inferred from direct assay (Hummel et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8  (68) head, virgin 1-day female  (36) head, virgin 4-day female  (30) head, virgin 20-day female    17 head, mated 1-day female  (38) head, mated 4-day female  (32) head, mated 20-day female    16 head, mated 1-day male  (70) head, mated 4-day male  (67) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8  (68) head, virgin 1-day female  (36) head, virgin 4-day female  30 head, virgin 20-day female    17 head, mated 1-day female  (38) head, mated 4-day female  32 head, mated 20-day female    16 head, mated 1-day male  (70) head, mated 4-day male  (67) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    21 central nervous system, pupae P8    68 head, virgin 1-day female    36 head, virgin 4-day female    30 head, virgin 20-day female    17 head, mated 1-day female    38 head, mated 4-day female    32 head, mated 20-day female    16 head, mated 1-day male    70 head, mated 4-day male    67 head, mated 20-day male    48 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    6 carcass, larvae L3 wandering    5 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    8 pupae 2d postWPP    14 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    8 adult male 30day    6 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    0 ovary fGS/OSS    6 ovary OSC    21 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259108 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14772-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal futschP158 lethal | recessive futschPG97 viable futschK68 viable, with Scer\GAL4pnr-MD237 futschGD1263 Sterility Allele male fertile futschN94 Other Phenotypes Allele auditory perception defective | adult stage futschK68 increased cell death | adult stage futscholk1 learning defective | adult stage futscholk1 futscholk3 neuroanatomy defective futschN94 neuroanatomy defective, with Scer\GAL4elav-C155 futschEP1419 neuroanatomy defective | adult stage futscholk1 neuroanatomy defective | larval stage futschK68 neuroanatomy defective | recessive futschK68 futschN94 neuroanatomy defective | third instar larval stage futschK68 futschN94 neurophysiology defective futschN94 neurophysiology defective, with Scer\GAL4elav-C155 futschEP1419 smell perception defective | adult stage futscholk1 Phenotype manifest in Allele abdominal posterior fascicle neuron futschP158 adult brain futscholk1 antennal lobe futscholk1 axon futschP158 axon, with Scer\GAL4sim.PS futschEP1419 bouton futschK68 futschN94 bouton, with Scer\GAL4elav-C155 futschEP1419 bouton | third instar larval stage futschK68 futschN94 longitudinal connective futschP158 microtubule & antennal lobe futscholk1 mitochondrion futschN94 mitochondrion & neuron futscholk1 motor neuron futschP158 mushroom body calyx futscholk1 neuromuscular junction futschN94 neuromuscular junction, with Scer\GAL4elav-C155 futschEP1419 neuropil futscholk1 photoreceptor cell futschN94 photoreceptor cell, with Scer\GAL4elav-C155 futschEP1419 protocerebrum futscholk1 sensory nerve & dendrite futschP158 synapse futschK68 futschN94 synapse, with Scer\GAL4elav-C155 futschEP1419 synapse & microtubule futschK68 futschN94
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of futsch Class Mutagen Stocks Known lesion futschEP1419 P-element activity 1 Yes futschf03697 1 -- futschK68 hypomorphic allele - genetic evidence 1 -- futschMB09452 1 -- futschN94 hypomorphic allele - genetic evidence 1 -- futschP158 amorphic allele - genetic evidence 0 -- futschEC2 0 -- futschM455 0 -- futscholk1 0 Yes futscholk2 hypomorphic allele - genetic evidence 0 -- futscholk3 hypomorphic allele - genetic evidence 0 -- futschP28 0 -- futschPG97 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of futsch Class Mutagen Stocks Known lesion futschGD1263 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes futschHMS02000 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes futschC-Term.Scer\UAS in vitro construct - regulatory fusion 0 Yes futschGD8438 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes futschN+C-Term.Scer\UAS in vitro construct - regulatory fusion 0 Yes futschN-Term.Scer\UAS in vitro construct - regulatory fusion 0 Yes futschNPC-Term.Scer\UAS in vitro construct - regulatory fusion 0 Yes futschNterm.Scer\UAS in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes futschΔN-term.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes futschΔN-term.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)A94 (Hummel et al., 2000) Df(1)AC7 (Hummel et al., 2000) Df(1)AD11 (Zou et al., 2008) Df(1)Exel6227 (Ryder, 2004.4.26) Df(1)RH4 (Hummel et al., 2000) Df(1)S39 (Hummel et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1263} NA P{GD8438} NA P{TRiP.HMS02000} NA P{UAS-futsch.C-Term} NA P{UAS-futsch.N+C-Term} NA P{UAS-futsch.NPC-Term} NA P{UAS-futsch.N-Term} NA P{UAS-Nterm.futsch} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}futschEP1419 NA miscellaneous insertions P{SUPor-P}KG03606 NA PBac{WH}futschf03697 NA insertion of enhancer trap binary system Mi{ET1}futschMB09452 No P{GAL4}C380 No P{GawB}futschPG97 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from direct assay (Roos et al., 2000) inferred from direct assay AND inferred from sequence or structural similarity with UniProtKB:P46821 (Hummel et al., 2000) protein binding inferred from physical interaction with Fmr1 (Zhang et al., 2001)
Biological Process
CV term Evidence References
axon cargo transport inferred from mutant phenotype (Bettencourt da Cruz et al., 2005) axonogenesis inferred from mutant phenotype (Hummel et al., 2000) dendrite morphogenesis inferred from mutant phenotype (Hummel et al., 2000) microtubule cytoskeleton organization inferred from mutant phenotype (Roos et al., 2000) negative regulation of neuron apoptotic process inferred from mutant phenotype (Bettencourt da Cruz et al., 2005) neurofilament cytoskeleton organization inferred from mutant phenotype (Bettencourt da Cruz et al., 2005) olfactory learning inferred from mutant phenotype (Bettencourt da Cruz et al., 2005) regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Franco et al., 2004, Roos et al., 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hummel et al., 2000, Roos et al., 2000) microtubule cytoskeleton inferred from direct assay (Hummel et al., 2000)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
hydrolase activity inferred from electronic annotation with InterPro:IPR001279 (FlyBase Curators et al., 2004-) microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000, EDGP Project Members, 1994-)
Biological Process
CV term Evidence References
compound eye development non-traceable author statement (Oostra, 2002) microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) nervous system development non-traceable author statement (Oostra, 2002) neuromuscular junction development non-traceable author statement (Oostra, 2002)
Cellular Component
CV term Evidence References
microtubule inferred from electronic annotation with InterPro:IPR026074 (FlyBase Curators et al., 2004-) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000, EDGP Project Members, 1994-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene (Bettencourt da Cruz et al., 2005)
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
futsch - Hcs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) futsch - santa-maria anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions futsch allele Gene References futschN94 Fmr1 (Zhang et al., 2001) unspecified flexin (Roos et al., 2000) Fmr1 (Bettencourt da Cruz et al., 2005) tau (Bettencourt da Cruz et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 625175 DroID - A comprehensive database of gene and protein interactions. • FBgn0259108 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 5740544
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FTWKB Dipteran inclusive ortholog search EOG6D26Z5 Insect inclusive ortholog search EOG62V7B2 Arthropod inclusive ortholog search EOG6QBZM4 Metazoa inclusive ortholog search EOG6W45DM
Orthologs in Drosophila Species (EOG6FTWKB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\pygo     Drosophila melanogaster fruit fly  Dmel\futsch     Drosophila melanogaster fruit fly  Dmel\A2bp1     Drosophila melanogaster fruit fly  Dmel\CG13068     Drosophila erecta   Dere\GG17842   Y Drosophila erecta   Dere\GG23534   Y Drosophila erecta   Dere\GG15438   Y Drosophila erecta   Dere\futsch   Y Drosophila yakuba   Dyak\GE16228   Y Drosophila yakuba   Dyak\GE13919   Y Drosophila yakuba   Dyak\GE21749   Y Drosophila yakuba   Dyak\GE18704   Y Drosophila yakuba   Dyak\GE16687   Y Drosophila ananassae   Dana\GF12771   Y Drosophila ananassae   Dana\GF21016   Y Drosophila persimilis   Dper\GL14252   Y Drosophila willistoni   Dwil\GK23126   Y Drosophila willistoni   Dwil\GK15084   Y Drosophila willistoni   Dwil\GK17683   Y Drosophila willistoni   Dwil\GK16856   Y Drosophila willistoni   Dwil\GK24846   Y Drosophila willistoni   Dwil\GK16278   Y Drosophila willistoni   Dwil\GK17163   Y Drosophila willistoni   Dwil\GK23239   Y Drosophila willistoni   Dwil\GK15277   Y Drosophila virilis   Dvir\GJ15230   Y Drosophila mojavensis   Dmoj\GI15698   Y Drosophila grimshawi   Dgri\GH22172   Y Drosophila grimshawi   Dgri\GH10947   Y Drosophila grimshawi   Dgri\GH14949   Y Drosophila grimshawi   Dgri\GH11381   Y Drosophila grimshawi   Dgri\GH19116   Y Drosophila grimshawi   Dgri\GH21846   Y Drosophila grimshawi   Dgri\GH24882   Y
Orthologs in non-Drosophila Dipterans (EOG6D26Z5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011181 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009847 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007042 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007155 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000869 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001194 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013059 Y
Orthologs in non-Dipteran Insects (EOG62V7B2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49223 Y Apis mellifera Western honey bee  Amel\GB48862 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019950 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011333 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000493 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13728 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14789 Y Atta cephalotes Leafcutter ant  Acep\ACEP23131 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13277 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12623 Y Linepithema humile Argentine ant  Lhum\LH26236 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27254 Y Solenopsis invicta Red fire ant  Sinv\SINV22270 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000252 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI073896 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007208 Y Pediculus humanus Human body louse  Phum\PHUM399550 Y Tribolium castaneum Red flour beetle  Tcas\TC001001 Y
Orthologs in non-Insect Arthropods (EOG6QBZM4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW009767 Y
Orthologs in non-Arthropod Metazoa (EOG6W45DM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F32A7.5 Y Caenorhabditis elegans Nematode  Cele\C36A4.5 Y Danio rerio Zebrafish  Drer\map1aa Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	8794 y1 futschK68 8805 y1 futschN94 10751 P{EP}futschEP1419 w1118 27783 Mi{ET1}futschMB09452 w1118 40834 y1 v1; P{TRiP.HMS02000}attP40
Harvard	- PBac{WH}futschf03697
VDRC	v6972 w1118; P{GD1263}v6972 v6973 w1118; P{GD1263}v6973
Genomic Clones ( 2 )
	BACR09H15 BACR30G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH26828
Other clones	IP18437 IP18737
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04292 GH21135
Other clones	32927 32991 33555 44961 51503 52753 57983 58215 79379 108348 149065 156748 CK01.142B.A12 DMG1-chrX.2.035.a DMG7-chrX.3.004.pred.a.3prime EK119034 EK142845 EK143048 EK160750 EK165941 EK168839 EK180619 EK208964 EK249304 EK254456 EK260044 GH06062 GH27181 IP18537 IP18637 SD17959
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259108 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 5740544
Antibody Information
	polyclonal (Zou et al., 2008, Gogel et al., 2006)
Other Information
Discoverer
Etymology
	futsch is German for "gone". (Hummel et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: EG:49E4.1 CG3064 (Bayraktaroglu, 2000.4.7) Source for merge of: futsch CG14772 (FlyBase Genome Annotators, 2007) Source for merge of: futsch EG:49E4.1 (Gatt, 2000.11.14) Source for merge of: futsch olk (Bettencourt da Cruz et al., 2005)
Additional comments	Annotations CG3064 and CG14772 merged as CG34387 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Either loss or overexpression of Fmr1 or futsch have identical effects on synaptic transmission - elevation at the NMJ and suppression in photoreceptor cells. (Zhang et al., 2001) futsch is necessary for dendritic and axonal growth. (Hummel et al., 2000) futsch may control synaptic growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. (Roos et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103394 NM_001169161 NM_001258532 RefSeq (Proteins) • NP_001096864 NP_001162632 NP_001245461 DDBJ / EMBL / GenBank • AAF45622 ABW09325 AFH07176 AI389853 AL031128 AQ025455 BI636317 CAA20006 Entrez Gene - A searchable database of RefSeq genes. • 5740544 UniProtKB/Swiss-Prot • Q9W596
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Microtubule associated protein Futsch (IPR009603) Beta-lactamase-like (IPR001279) Microtubule associated protein 1 (IPR026074)
Linkouts
	BioGRID - A database of protein and genetic interactions • 625175 DroID - A comprehensive database of gene and protein interactions. • FBgn0259108 DRSC - Results from RNAi screens. • FBgn0259108 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259108 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14772-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259108 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 5740544 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/futsch1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 5740544 modMine - Data generated by the modENCODE project. • FBgn0259108
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	22C10 (Liu et al., 2009, Mehnert et al., 2007, Bharadwaj et al., 2013, McDonald et al., 2003, Hebbar and Fernandes, 2004, Dulcis et al., 2005, Ashley et al., 2005, Fischler et al., 2007, Dutta et al., 2005, Singh et al., 2006, Sweeney et al., 2006, Sanchez, 2006, Sanchez et al., 2006, Beronja et al., 2005, Yamamoto, 2006, Rogers et al., 2005, Acar et al., 2006, Wheeler et al., 2006, Ataman, 2006, Park et al., 2006, Sengupta and Lakhotia, 2006, Chu-LaGraff et al., 2007, Fernandes and Krishan, 2007, Sterling et al., 2007, Bessa and Casares, 2005, Sanchez-Soriano et al., 2005, Wildonger and Mann, 2005, Monier et al., 2005, Schubiger et al., 2005, Coulson et al., 2005, Read et al., 2005, Yano et al., 2005, Singh et al., 2005, Mizutani et al., 2005, Bhalerao et al., 2005, Escudero et al., 2005, Mace and Tugores, 2004, Gong et al., 2004, Usui-Ishihara and Simpson, 2005, Pielage et al., 2004, Read et al., 2004, Kinrade and Hidalgo, 2004, Bhat, 2005, Lee et al., 2005, Grabbe et al., 2004, Niwa et al., 2004, Islam et al., 2004, Mellerick and Modica, 2002, Andrenacci et al., 2004, Schmid et al., 2002, Domingos et al., 2004, Langlais et al., 2004, Koh et al., 2004, Beck et al., 2004, Singh and Choi, 2003, Artero et al., 2003, Han et al., 2003, Yamada et al., 2003, Schenck et al., 2003, Yang et al., 2003, Sepp and Auld, 2003, Weng et al., 2003, Reim et al., 2003, Villa-Cuesta et al., 2003, Inbal et al., 2003, Koelzer and Klein, 2003, Shandala et al., 2003, Xu et al., 2002, Kambris et al., 2002, Grueber et al., 2003, Song et al., 2002, Moore et al., 2002, Song et al., 2002, Dubruille et al., 2002, Wang et al., 2002, Packard et al., 2002, Uhler et al., 2002, Dumstrei et al., 2002, Rusten et al., 2002, Soustelle et al., 2002, Terman et al., 2002, Eaton et al., 2002, Schenkel et al., 2002, Hardiman et al., 2002, Goberdhan and Wilson, 2002, Sweeney et al., 2002, Umesono et al., 2002, Tekotte et al., 2002, Marques et al., 2002, Ozon et al., 2002, Jhaveri and Rodrigues, 2002, Bulgheresi et al., 2001, Murawsky et al., 2001, Kumar et al., 2001, Ramain et al., 2001, Inbal et al., 2001, Sepp et al., 2001, Quinn et al., 2001, Badenhorst, 2001, Mehta and Bhat, 2001, Jones, 2001, Alonso et al., 2001, Schimmelpfeng et al., 2001, Adachi et al., 2001, Kammermeier et al., 2001, Vandaele et al., 2001, Kataoka et al., 2001, Koizumi et al., 2001, Plaza et al., 2001, Rusten et al., 2001, Ben-Yaacov et al., 2001, Quinn et al., 2000, Geng et al., 2000, Yeh et al., 2000, Usui-Ishihara et al., 2000, Nolo et al., 2000, Hiramoto et al., 2000, Chen and Rebay, 2000, Brown and Castelli-Gair Hombria, 2000, Connell-Crowley, 2000, Schmucker et al., 2000, Ishimoto et al., 2000, Bour et al., 2000, Aguilera et al., 2000, White and Jarman, 2000, Hoyle et al., 2000, Kuang et al., 2000, Eberl et al., 2000, Kurant and Salzberg, 2000, Schubiger and Truman, 2000, Lai et al., 2000, Justice et al., 1999, Irion and Leptin, 1999, Bhat et al., 2000, Lilly et al., 1999, Lear et al., 1999, Helms et al., 1999, Gao et al., 1999, Byars et al., 1999, Auld, 1999, Ashraf et al., 1999, Madden et al., 1999, Merianda et al., 2005, Layalle et al., 2005, Melcher and Pankratz, 2005, With et al., 2003, Grillenzoni et al., 2007, Holohan et al., 2006, Guntur and Lundell, 2008, Liu et al., 2007, Davis et al., 2005, Rand et al., 2009, Dutta et al., 2010, Zhang et al., 2011, Mellerick and Liu, 2004, Sprecher et al., 2011, Zhu and Bhat, 2011, Xin et al., 2011, Besson et al., 2011, Belacortu et al., 2011, Keene et al., 2011, Mukherjee et al., 2011, Pandey et al., 2011, Schmidt et al., 2011, Bolkan et al., 2012, Li-Kroeger et al., 2008, Bhat, 2007, Ratnaparkhi and Zinn, 2007, Le Gall et al., 2008, Taylor and Adler, 2008, Crozatier and Vincent, 2008, Lundell et al., 1996, Cornbrooks et al., 2007, Chang et al., 2006, Erclik et al., 2008, Sevrioukov et al., 2007, Górska-Andrzejak et al., 2009, Powell et al., 2004, Verstreken et al., 2005, zur Lage et al., 2004, Buch et al., 2008, Beramendi et al., 2007, Ahantarig et al., 2009, Kamikouchi et al., 2006, Hoehne et al., 2005, Udolph et al., 2009, Chang and Min, 2009, Kristiansen et al., 2005, Figeac et al., 2010, Sokol et al., 2008, Sehadova et al., 2009, Pereira et al., 2006, Schneider and Baumgartner, 2008, Sato et al., 2010, Kain et al., 2008, Zou et al., 2008, Rajendra et al., 2007, Klein et al., 2010, Kopytova et al., 2006, Kim et al., 2007, Lee et al., 2010, Billeter et al., 2006, zur Lage and Jarman, 2010, Herr et al., 2010, Nguyen et al., 2011, Michaud and Tanguay, 2003, Llorens et al., 2007, Stewart et al., 2012, Sato and Shibuya, 2013, Orian et al., 2007, Wang et al., 2011, Matsubara et al., 2011, Yamasaki et al., 2011, Mohtashami et al., 2001, Bader et al., 2007, Lee et al., 2011, Berzsenyi et al., 2011, Hiramoto and Hiromi, 2006, Quijano et al., 2011, Navarro et al., 2011, Patel et al., 2012, Newton et al., 2012) 22c10 (Griffiths et al., 2007, Momota et al., 2011, Griffiths and Hidalgo, 2004, Ragone et al., 2003, Yeh et al., 2001, Durand et al., 2001, Taniguchi et al., 2000, Hidalgo and Booth, 2000, Booth et al., 2000, Zweier et al., 2009) 22C10/FUTSCH (Sedaghat et al., 2002) 22C20 (Bennett et al., 2008) CG3064 (Benos, 2000.12.13, Goldstein and Gunawardena, 2000, ) CG14772   CG34387 (FlyBase Genome Annotators, 2007, Ni et al., 2010.12.1) EG:49E4.1 (Bolshakov et al., 2002, Benos et al., 2001, Benos, 2000.12.13, Gatt, 2000.11.14, Hummel et al., 2000, ) Futch (Neely et al., 2010) futsch (Kurshan et al., 2009, Gogel et al., 2006, Bao et al., 2007, Sweeney et al., 2006, Bossing and Brand, 2006, Denman, 2006, Wheeler et al., 2006, Ko et al., 2006, Wiggin et al., 2005, Ashley et al., 2005, Bettencourt da Cruz et al., 2005, Franco et al., 2004, Monzo et al., 2006, Schimmelpfeng et al., 2006, Davis et al., 2005, Marques, 2005, Hazelett et al., 2012, Godena et al., 2011, Kissler et al., 2009, Tian et al., 2011, Pandey et al., 2011, Viquez et al., 2006, Pielage et al., 2008, Koch et al., 2008, Miech et al., 2008, Zou et al., 2008, Sanyal, 2009, Lawlor et al., 2011, Wentzell et al., 2012, Stewart et al., 2012, Lee et al., 2010, Cachero et al., 2011, Wasbrough et al., 2010, Freeman et al., 2011, Nishimura et al., 2008, Chang et al., 2008, Kallijärvi et al., 2012, Abruzzi et al., 2011, Nechipurenko and Broihier, 2012, Koon et al., 2011, Sarthi and Elefant, 2011, Kim et al., 2012, Senthilan et al., 2012, Nfonsam et al., 2012) Futsch (Forni et al., 2004, Mehnert et al., 2007, Strigini et al., 2006, Ratnaparkhi et al., 2008, Miśkiewicz et al., 2011, Stork et al., 2008, Elliott et al., 2005, Kracklauer et al., 2007, Gao and Bogert, 2003, Wang et al., 2007, Orgogozo et al., 2007, Massaro et al., 2009, Lin et al., 2010, Coffee et al., 2012, Besse et al., 2007, Wheeler et al., 2008, Pawson et al., 2008, Lim and Kraut, 2009, Lee et al., 2008, Bennett et al., 2008, Palgi et al., 2009, Siebert et al., 2009, Lin et al., 2009, Hoehne et al., 2005, Jin et al., 2009, Viquez et al., 2009, Sharma and Nirenberg, 2007, Simon et al., 2009, Klein et al., 2010, Ellis et al., 2010, Nishimura et al., 2008, Johnson et al., 2006, Schulte et al., 2010, Cheng et al., 2010, Melicharek et al., 2010, Nagai et al., 2010, Jinushi-Nakao et al., 2007, Albornoz et al., 2008, Du et al., 2010, Lee et al., 2011, Bachmann et al., 2008, Lloyd et al., 2012, Mosca et al., 2012) FUTSCH (Chu-Lagraff et al., 2010) mAb22C10 (Yasunaga et al., 2006, Harris and Whitington, 2001, Kraut and Zinn, 2004, Sen et al., 2004, Parsons et al., 2003, Jang et al., 2003, Sen et al., 2003, Suh et al., 2002, Chang et al., 2001, Kaminker et al., 2001, Takizawa and Hotta, 2001, Lukacsovich et al., 2001, Usui-Aoki et al., 2000, Jhaveri et al., 2000, Cheah et al., 2000, Senti et al., 2000, Goulding et al., 2000, Goulding et al., 2000, Newsome et al., 2000, Wan et al., 2000, Schock et al., 1999, Baker et al., 1992) mAb 22C10 (Ivanov et al., 2004, Escudero et al., 2003, Llimargas, 2000, Hummel et al., 2000, Genova et al., 2000, Lee et al., 2000, Greenwood and Struhl, 1999, Garcia-Alonso, 1999, Sawamoto et al., 1999, Staudt et al., 2006, Schulte et al., 2010) MAb22C10 (Lai and Orgogozo, 2004, zur Lage et al., 2003, Huang et al., 2000, Nassif et al., 1998, O'Farrell and Kylsten, 2008) Mab22C10 (Rau et al., 2001, Mozer, 2001, Awasaki and Kimura, 2001, Boulton et al., 2000, Matthews and Crews, 1999, Alone et al., 2005) mAb-22C10 (Dettman et al., 2001) Mab 22C10 (Kurant et al., 2001) mAb22c10 (Acevedo et al., 2007) Mab22c10 (Gonzalez-Gaitan and Jackle, 2000) MAP1B (Moine and Mandel, 2001, Coffee et al., 2012, Toda et al., 2008, Lee et al., 2008, Xiong et al., 2010, Du et al., 2010) map1b (Sohn, 2001) Map1B (Beck et al., 2012) Map-1B (Beck et al., 2012) MAP-IB (Merianda et al., 2005) olk (Bettencourt da Cruz et al., 2005) Olk (Herranz et al., 2010) ssC10 (Giesen et al., 2003)
Name Synonym	CG14772   Futch (Laurençon et al., 2007) Futsch (Forni et al., 2004, Strigini et al., 2006, Rogers et al., 2005, Ataman et al., 2006, Medina et al., 2006, Kretzschmar et al., 2005, Wang et al., 2007, Beuchle et al., 2007, Rand et al., 2009, Mellerick and Liu, 2004, Bury et al., 2008, Beramendi et al., 2007, Pack-Chung et al., 2007, Viquez et al., 2009, Simon et al., 2009, Klein et al., 2010, Adolph et al., 2009, Mosca and Schwarz, 2010, Boerner and Duch, 2010, Xiong et al., 2010, Enjolras et al., 2012, Kuzina et al., 2011, Rossetto et al., 2011, Mast et al., 2011) futsch (Gogel et al., 2006, Bao et al., 2007, Hummel et al., 2000, Martinek et al., 2008, Gatto and Broadie, 2008, Cachero et al., 2011) omb-like (Bettencourt da Cruz et al., 2005)
Secondary FlyBase IDs
	FBgn0015390 FBgn0025392 FBgn0029577 FBgn0029578 FBgn0085416 FBgn0243483
References ( 474 )
Generate a list of	All references relating to this gene ( 474 )
List References by type	Research paper  ( 395 ) Supplementary material  ( 16 ) Review  ( 27 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 13 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 4 )
Recent research papers ( 50 )
	Bharadwaj et al., 2013, Development 140(3): 627--638 Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. [FBrf0220383] Hopkins, 2013, PLoS ONE 8(2): e55810 Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein. [FBrf0220834] Sato and Shibuya, 2013, PLoS ONE 8(1): e55301 WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression. [FBrf0220694] Beck et al., 2012, J. Neurosci. 32(20): 7058--7073 Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385] Bolkan et al., 2012, J. Neurosci. 32(46): 16181--16192 beta-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival. [FBrf0219983] Coffee et al., 2012, Hum. Mol. Genet. 21(4): 900--915 In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. [FBrf0217253] Enjolras et al., 2012, J. Cell Biol. 197(2): 313--325 Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling. [FBrf0218054] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Kallijärvi et al., 2012, PLoS ONE 7(12): e51997 Characterization of Drosophila GDNF Receptor-Like and Evidence for Its Evolutionarily Conserved Interaction with Neural Cell Adhesion Molecule (NCAM)/FasII. [FBrf0220419] Kim et al., 2012, Genes Dev. 26(9): 974--987 Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. [FBrf0218161] Lloyd et al., 2012, Neuron 74(2): 344--360 The p150(Glued) CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. [FBrf0218160] Mosca et al., 2012, Nature 484(7393): 237--241 Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. [FBrf0218053] Nechipurenko and Broihier, 2012, J. Cell Biol. 196(3): 345--362 FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. [FBrf0217391] Newton et al., 2012, Dev. Cell 22(6): 1221--1233 Forkhead Transcription Factor Fd3F Cooperates with Rfx to Regulate a Gene Expression Program for Mechanosensory Cilia Specialization. [FBrf0218629] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Patel et al., 2012, J. Exp. Zool. B Mol. Dev. Evol. 318(5): 368--387 Dramatic expansion and developmental expression diversification of the methuselah gene family during recent Drosophila evolution. [FBrf0218628] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Stewart et al., 2012, J. Neurosci. 32(34): 11631--11642 Katanin p60-like1 Promotes Microtubule Growth and Terminal Dendrite Stability in the Larval Class IV Sensory Neurons of Drosophila. [FBrf0219283] Wentzell et al., 2012, Neurobiol. Disease 46(1): 78--87 Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration. [FBrf0217742] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Belacortu et al., 2011, Gene Expr. Patterns 11(3-4): 190--201 Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development. [FBrf0213309] Berzsenyi et al., 2011, J. Neurosci. 31(39): 13722--13727 Homeostatic interactions at the front of migration control the integrity and the efficiency of a migratory glial chain. [FBrf0216274] Besson et al., 2011, J. Comp. Neurol. 519(14): 2734--2757 Involvement of the drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions. [FBrf0214574] Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Freeman et al., 2011, Mol. Cell. Neurosci. 46(2): 535--547 NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. [FBrf0212894] Godena et al., 2011, PLoS ONE 6(3): e17808 TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization. [FBrf0213270] Keene et al., 2011, J. Neurosci. 31(17): 6527--6534 Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. [FBrf0213587] Koon et al., 2011, Nat. Neurosci. 14(2): 190--199 Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0212895] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Lawlor et al., 2011, Hum. Mol. Genet. 20(19): 3757--3768 Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases. [FBrf0215240] Lee et al., 2011, Mol. Cells 32(5): 477--482 The phosphoinositide phosphatase Sac1 is required for midline axon guidance. [FBrf0216733] Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. [FBrf0215017] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Miśkiewicz et al., 2011, Neuron 72(5): 776--788 ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot. [FBrf0216903] Momota et al., 2011, Matrix Biol. 30(4): 258--266 Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. [FBrf0213898] Mukherjee et al., 2011, Development 138(11): 2347--2357 The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis. [FBrf0213663] Navarro et al., 2011, PLoS ONE 6(7): e21017 Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels. [FBrf0214483] Nguyen et al., 2011, Neural Dev. 6: 38 Microtubules are organized independently of the centrosome in Drosophila neurons. [FBrf0217384] Pandey et al., 2011, PLoS ONE 6(11): e28106 The Glucuronyltransferase GlcAT-P Is Required for Stretch Growth of Peripheral Nerves in Drosophila. [FBrf0216828] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. [FBrf0216330] Sarthi and Elefant, 2011, PLoS ONE 6(10): e26202 dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction. [FBrf0216592] Schmidt et al., 2011, Glia 59(9): 1264--1272 Transcriptional regulation of peripheral glial cell differentiation in the embryonic nervous system of drosophila. [FBrf0214270] Sprecher et al., 2011, Dev. Biol. 358(1): 33--43 The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil. [FBrf0215208] Tian et al., 2011, Nat. Neurosci. 14(10): 1267--1275 Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. [FBrf0216253] Wang et al., 2011, Int. J. Dev. Biol. 55(2): 223--227 Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1. [FBrf0213886] Xin et al., 2011, Development 138(22): 4955--4967 Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. [FBrf0216486] Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. [FBrf0214536] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Zhu and Bhat, 2011, Dev. Biol. 357(2): 283--294 The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. [FBrf0214765] Show all research papers ...
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	All reviews listed in FlyBase were published before 2011 Show reviews ...