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Gene Dmel\Clbn

General Information
Symbol	Dmel\Clbn	Species	D. melanogaster
Name	Caliban	Annotation symbol	CG11847
Feature type	protein_coding_gene	FlyBase ID	FBgn0259152
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C1-96C1	Sequence location	3R:20,953,224..20,956,877 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Caliban is referred to in FlyBase by the symbol Dmel\Clbn (CG11847, FBgn0259152). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: protein export from nucleus. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Domain of unknown function DUF814; Fibronectin-binding A, N-terminal; Protein of unknown function DUF3441. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623888_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Clbn. Gene sequence location is 3R:20953224..20956877.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Insertions Mi{MIC}Clbn[MI03924] References Bellen, 2011.10.10, MISet953.xml Alleles Clbn[MI03924]
FB2012_01	Sequence features BKN20167 HFA14404
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C1-96C1   Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Clbn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Clbn-RB FBtr0301277  NM_001170250   3270   992 Clbn-RC FBtr0301278  NM_143084   3258   992
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Clbn-PB   FBpp0290492   112.6   992   7.17     NP_001163721   ACZ95015 Clbn-PC   FBpp0290493   112.6   992   7.17     NP_651341   AAF56406
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin-binding A, N-terminal (IPR008616) Domain of unknown function DUF814 (IPR008532) Protein of unknown function DUF3441 (IPR021846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56406   AE014297 ACZ95015   BT023855   BT030842   BT120132   CO265098   CO272948   CZ468138   EC060419   EC072110   EC221670   EC260604   EL883332   EL883333   EL883448   EL883449
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VBX1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259152    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259152 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259152 expression level Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1439) embryo 02-04hr  (339) embryo 04-06hr  (347) embryo 06-08hr  (341) embryo 08-10hr  (419) embryo 10-12hr  (380) embryo 12-14hr  (594) embryo 14-16hr  (236) embryo 16-18hr  (403) embryo 18-20hr  (293) embryo 20-22hr  (452) embryo 22-24hr  (594) larva L1  (610) larva L2  (902) larva L3 12hr old  (710) larva L3 puffstage 1-2  (581) larva L3 puffstage 3-6  (717) larva L3 puffstage 7-9  (1058) white prepupae new  (1077) white prepupae 12hr  (648) white prepupae 24hr  (744) pupae 2d postWPP  (697) pupae 3d postWPP  (555) pupae 4d postWPP  (266) adult male 01day  (621) adult male 05day  (556) adult male 30day  (366) adult female 01day  (622) adult female 05day  (1753) adult female 30day  (1556) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day  (1753) adult female 30day  (1556) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259152 expression level Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1439) embryo 02-04hr  (339) embryo 04-06hr  (347) embryo 06-08hr  (341) embryo 08-10hr  (419) embryo 10-12hr  (380) embryo 12-14hr  (594) embryo 14-16hr  (236) embryo 16-18hr  (403) embryo 18-20hr  (293) embryo 20-22hr  (452) embryo 22-24hr  (594) larva L1  (610) larva L2  (902) larva L3 12hr old  (710) larva L3 puffstage 1-2  (581) larva L3 puffstage 3-6  (717) larva L3 puffstage 7-9  (1058) white prepupae new  (1077) white prepupae 12hr  (648) white prepupae 24hr  (744) pupae 2d postWPP  (697) pupae 3d postWPP  (555) pupae 4d postWPP  (266) adult male 01day  (621) adult male 05day  (556) adult male 30day  (366) adult female 01day  (622) adult female 05day  (1753) adult female 30day  (1556) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day  1753 adult female 30day  1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1439 embryo 02-04hr    339 embryo 04-06hr    347 embryo 06-08hr    341 embryo 08-10hr    419 embryo 10-12hr    380 embryo 12-14hr    594 embryo 14-16hr    236 embryo 16-18hr    403 embryo 18-20hr    293 embryo 20-22hr    452 embryo 22-24hr    594 larva L1    610 larva L2    902 larva L3 12hr old    710 larva L3 puffstage 1-2    581 larva L3 puffstage 3-6    717 larva L3 puffstage 7-9    1058 white prepupae new    1077 white prepupae 12hr    648 white prepupae 24hr    744 pupae 2d postWPP    697 pupae 3d postWPP    555 pupae 4d postWPP    266 adult male 01day    621 adult male 05day    556 adult male 30day    366 adult female 01day    622 adult female 05day    1753 adult female 30day    1556 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259152    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259152 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259152 expression level Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259152 expression level Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    154.35 Larval Midgut    162.3 Larval Hindgut    166.5 Larval Malpighian Tubules    222.4 Larval Fat Body    150.1 Larval Salivary Gland    294.9 Larval Trachea    194.65 Larval Carcass    190.275 Adult Head    137.3 Adult Eye    170.725 Adult Brain    184 Adult Thoracic-Abdominal Ganglion    176.6 Adult Crop    133.5 Adult Midgut    164.7 Adult Hindgut    144.9 Adult Malpighian Tubules    253.6 Adult Fat Body    114.6 Adult Salivary Gland    269.6 Adult Heart    128.7 Adult VirginFemale Spermatheca    191.7 Adult InseminatedFemale Spermatheca    238 Adult Ovary    246.3 Adult Testis    79.7 Adult Male Accessory Gland    491.3 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    137.3   NA  Eye    170.725   NA  Brain    184   154.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    176.6   NA  Crop    133.5   162.3  Midgut    164.7   166.5  Hindgut    144.9   222.4  Malpighian Tubules    253.6   150.1  Fat Body    114.6   294.9  Salivary Gland    269.6   NA  Heart    128.7   194.65  Trachea    NA   NA  VirginFemale Spermatheca    191.7   NA  InseminatedFemale Spermatheca    238   NA  Ovary    246.3   NA  Testis    79.7   NA  Male Accessory Gland    491.3   190.275  Carcass    124.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11847-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 ClbnGD7403 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Clbn Class Mutagen Stocks Known lesion Clbnc02681 piggyBac transposase 1 -- ClbnMB03253 1 -- ClbnMI03924 1 -- Clbnc03103 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Clbn Class Mutagen Stocks Known lesion ClbnGD7403 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ClbnKK100071 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100071} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ClbnMI03924 NA PBac{PB}Clbnc02681 NA PBac{PB}Clbnc03103 NA insertion of enhancer trap binary system Mi{ET1}ClbnMB03253 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein export from nucleus inferred from mutant phenotype (Bi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Clbn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67938 DroID - A comprehensive database of gene and protein interactions. • FBgn0259152 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43018
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17891 Dere\GG11364 Dgri\GH19576 Dmoj\GI23827 Dper\GL21904 Dsec\GM17806 Dsim\GD21177 Dvir\GJ23608 Dwil\GK13887 Dyak\GE23561
Curated drosophilid orthologs	Dpse\GA11232
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14887 NV11318 LH18302 ISCW000678 FBgn0240737 FBgn0215894 FBgn0210705 FBgn0192628 FBgn0172713 JGI_V11_305191 FBgn0159497 FBgn0146552 FBgn0127040 FBgn0103664 FBgn0094909 CPIJ013434 BGIBMGA000753 ACYPI001375 GB17050 AGAP002680 AAEL007639 PHUM452400 PHUM622580 GLEAN_09916
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36955 y1 w*; Mi{MIC}ClbnMI03924 25214 w1118; Mi{ET1}ClbnMB03253/TM6C, Sb1
Harvard	- PBac{PB}Clbnc02681
VDRC	v103351 P{KK100071}VIE-260B v38578 w1118; P{GD7403}v38578
Genomic Clones ( 1 )
	BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP12823
Other clones	IP12923 MIP15468
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	9680 13551 31623 EC260604 EK108937 EK141532 IP13023 IP13123
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43018
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Clbn CG11847 (Bi et al., 2005)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143084 NM_001170250 RefSeq (Proteins) • NP_651341 NP_001163721 DDBJ / EMBL / GenBank • AAF56406 ACZ95015 CZ468138 Entrez Gene - A searchable database of RefSeq genes. • 43018 UniProtKB/TrEMBL • Q9VBX1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fibronectin-binding A, N-terminal (IPR008616) Domain of unknown function DUF814 (IPR008532) Protein of unknown function DUF3441 (IPR021846)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67938 DroID - A comprehensive database of gene and protein interactions. • FBgn0259152 DRSC - Results from RNAi screens. • FBgn0259152 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11847-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43018 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43018 modMine - Data generated by the modENCODE project. • FBgn0259152 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14887 NV11318 LH18302 ISCW000678 FBgn0240737 FBgn0215894 FBgn0210705 FBgn0192628 FBgn0172713 JGI_V11_305191 FBgn0159497 FBgn0146552 FBgn0127040 FBgn0103664 FBgn0094909 CPIJ013434 BGIBMGA000753 ACYPI001375 GB17050 AGAP002680 AAEL007639 PHUM452400 PHUM622580 GLEAN_09916
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG11847 (Akdemir et al., 2007, Keleman et al., 2009.8.5) Clbn (Bi et al., 2005, )
Name Synonym	Caliban (Bi et al., 2004, Bi et al., 2005) CG11847   Clbn
Secondary FlyBase IDs
	FBgn0039281 FBgn0069903
References ( 16 )
Research paper	Akdemir et al., 2007, Oncogene 26(36): 5184--5193 p53 directs focused genomic responses in Drosophila. [FBrf0202061] Bi et al., 2005, Oncogene 24(56): 8229--8239 Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. [FBrf0191360]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2011.10.10, MISet953.xml MISet953.xml [FBrf0216368] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] BDGP TI submission, 2008.6.30, set797.xml set797.xml [FBrf0205058] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Bi et al., 2004, A. Dros. Res. Conf. 45: 227B Caliban (Clbn) tumor suppressor protein mediates nuclear export of Prospero. [FBrf0173807]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]