FlyBase Gene Report: Dmel\Pde9

General Information

Symbol

Dmel\Pde9

Species

D. melanogaster

Name

Phosphodiesterase 9

Annotation Symbol

CG42276

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259171

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Phosphodiesterase 9 (Pde9) encodes a putative phosphodiesterase expressed in Malpighian tubules and involved in neurogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

11C2-11C3

Sequence location

X:12,785,563..12,897,327 [-]

Recombination map

1-40

RefSeq locus

NC_004354 REGION:12785563..12897327

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-GMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN000886878

(assigned by GO_Central )

(Gaudet et al., 2011)

enables 3',5'-cyclic-nucleotide phosphodiesterase activity

inferred from sequence model

(Day, 2005)

inferred from biological aspect of ancestor with PANTHER:PTN000141984

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cGMP catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000886878

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cGMP-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN000886878

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cyclic nucleotide metabolic process

inferred from sequence model

(Day, 2005)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000141984

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

Protein Family (UniProt)

Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. (Q9I7S6)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Phosphodiesterase 9 (Pde9) encodes a putative phosphodiesterase expressed in Malpighian tubules and involved in neurogenesis. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES -: Cyclic-nucleotide phosphodiesterases are hydrolases that catalyze the hydrolysis of a nucleoside cyclic phosphate into a nucleoside phosphate.

Protein Function (UniProtKB)

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP.

(UniProt, Q9I7S6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pde9 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.52

Gene model reviewed during 5.44

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pde9-RB

FBtr0299635

NM_132606

6579

1526

Pde9-RD

FBtr0330395

NM_167340

6579

1623

Pde9-RE

FBtr0333524

NM_001272566

6444

1526

Pde9-RF

FBtr0333525

NM_001272567

12156

1526

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Pde9-PB

FBpp0288910

162.8

1526

6.14

NP_572834

AAG22348

Pde9-PD

FBpp0303421

173.8

1623

5.45

NP_727644

AAF48205

Pde9-PE

FBpp0305704

162.8

1526

6.14

NP_001259495

AGB95337

Pde9-PF

FBpp0305705

162.8

1526

6.14

NP_001259496

AGB95338

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1526 aa isoforms: Pde9-PB, Pde9-PE, Pde9-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pde9 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pde9 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pde9

View exonic expression by tissue for Dmel\Pde9

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259171

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3754-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3754

Flygut - An atlas of the Drosophila adult midgut

FBgn0259171

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pde9

Transgenic constructs containing regulatory region of Pde9

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Pde9^GD6491

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Pde9^GD6491

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Pde9^GD6491

viable

Pde9^EY06288

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Pde9^EY06288

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage

Pde9^GD6491

some die during pupal stage, with Scer\GAL4^pnr-MD237

Pde9^GD6491

visible, with Scer\GAL4^pnr-MD237

Pde9^GD6491

Phenotype manifest in

Allele

ganglion mother cell | larval stage

Pde9^GD6491

larval neuroblast | larval stage

Pde9^GD6491

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Pde9^GD6491

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PDE9A

6 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pde9a

6 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (21)

Rnor\Pde9a

5 of 13

Yes

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (22)

Xtro\LOC100493061

3 of 12

Yes

Xtro\pde4a

3 of 12

Yes

Xtro\pde4b

3 of 12

Yes

Xtro\pde4c

3 of 12

Yes

Xtro\pde4d

3 of 12

Yes

Xtro\pde9a

3 of 12

Yes

Xtro\pde2a

2 of 12

Xtro\pde3b

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\pde11a

2 of 12

Xtro\LOC101730602

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (27)

Drer\pde9a

6 of 15

Yes

Drer\si:dkey-219c10.4

6 of 15

Yes

Drer\pde9al

5 of 15

Yes

Drer\LOC571737

4 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\pde-4

3 of 15

Yes

Cele\pde-6

3 of 15

Yes

Cele\pde-2

2 of 15

Cele\pde-3

2 of 15

Yes

Cele\pde-5

2 of 15

Cele\pde-1

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PDE2

6 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901QU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17041

Drosophila persimilis

Dper\GL22965

Drosophila willistoni

Dwil\GK10275

Drosophila virilis

Dvir\GJ16925

Drosophila mojavensis

Dmoj\GI11066

Drosophila grimshawi

Dgri\GH24569

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502JP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015183

Glossina morsitans

Tsetse fly

Gmor\GMOY006591

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09238

Mayetiola destructor

Hessian fly

Mdes\Mdes008060

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009630

Anopheles darlingi

American malaria mosquito

Adar\ADAC004053

Anopheles gambiae

Malaria mosquito

Agam\AGAP002927

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014126

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02BF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis florea

Little honeybee

Aflo\2299741156

Apis mellifera

Western honey bee

Amel\GB52046

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10337

Bombus terrestris

Buff-tailed bumblebee

Bter\15213050

Linepithema humile

Argentine ant

Lhum\LH19125

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0009e2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025649

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG024917

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG029289

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08206

Tribolium castaneum

Red flour beetle

Tcas\TC000150

Pediculus humanus

Human body louse

Phum\PHUM155210

Rhodnius prolixus

Kissing bug

Rpro\RPRC002051

Cimex lectularius

Bed bug

Clec\CLEC004649

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01724

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0290 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013510

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_30651

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0691 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pde9a

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021553

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000009856

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

dnc

5 of 10

4 of 10

3 of 10

3 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDE9A; phosphodiesterase 9A

6 of 15

602973

PDE4A; phosphodiesterase 4A

3 of 15

600126

PDE4B; phosphodiesterase 4B

3 of 15

600127

PDE4C; phosphodiesterase 4C

3 of 15

600128

PDE4D; phosphodiesterase 4D

3 of 15

600129

ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE; ACRDYS2

acrodysostosis

PDE11A; phosphodiesterase 11A

3 of 15

604961

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2

primary pigmented nodular adrenocortical disease

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58623

DroID - A comprehensive database of gene and protein interactions.

FBgn0259171

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32233

MIST (protein-protein) - An integrated Molecular Interaction Database

Pde9

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Purine metabolism

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

cGMP effects

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-40

Cytogenetic map

11C2-11C3

Sequence location

X:12,785,563..12,897,327 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11C2-11C3

Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640^EP1626

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-40

(FlyBase, 2016)

1-40.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

42195

y¹ w^* Mi{MIC}Pde9^MI06972

51387

y¹ w^* Mi{MIC}Pde9^MI07305

56459

y¹ w^* Mi{MIC}Pde9^MI11773

56617

y¹ w^* Mi{MIC}Pde9^MI11510

59324

y¹ w^* Mi{MIC}Pde9^MI13116

59663

y¹ w^* Mi{MIC}Pde9^MI13916

77779

y¹ w^* Mi{Trojan-GAL4.1}Pde9^{MI07305-TG4.1}

32412

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00407}attP2

Kyoto

103859

y^* w^* P{GawB}Pde9^NP1032 / FM7c

VDRC

v106959

P{KK102818}VIE-260B

v14900

w¹¹¹⁸; P{GD6491}v14900

Genomic Clones (46)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM08676

Other clones

IP13804

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259171

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259171

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32233

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Pde9 CG32648

(Day and Davies, 2003.6.10)

Source for database merge of

Source for merge of: Pde9 CG3754

(FlyBase Genome Annotators, 2008)

Source for merge of: CG1627 CG3761 CG3765

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG32648 and CG3754 merged as CG42276 in release 5.8 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotations CG1627, CG3761 and CG3765 merged as CG32648 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32233

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9I7S6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VYJ0

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259171

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3754

Flygut - An atlas of the Drosophila adult midgut

FBgn0259171

FlyMine - An integrated database for Drosophila genomics

FBgn0259171

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32233

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000150

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42276

modMine - A data warehouse for the modENCODE project

FBgn0259171

Linkouts

BioGRID - A database of protein and genetic interactions.

58623

DroID - A comprehensive database of gene and protein interactions.

FBgn0259171

DRSC - Results frm RNAi screens

FBgn0259171

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259171

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3754-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259171

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32233

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Purine metabolism

MIST (protein-protein) - An integrated Molecular Interaction Database

Pde9

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

cGMP effects

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1627

CG32648

(Keleman et al., 2009.8.5, Derré et al., 2007, Day, 2005, Giot et al., 2003)

CG3754

CG3761

CG3765

CG42276

(Hosono et al., 2015, Ni et al., 2010.12.1, FlyBase Genome Annotators, 2008)

PDE9

(Clemens-Grisham et al., 2008, Day, 2005, Day and Davies, 2003.6.10)

Pde9

(Shahandeh et al., 2020, Gene Disruption Project members, 2016-, Morgante et al., 2015, Ashwal-Fluss et al., 2014, Vernes, 2014, Hazelett et al., 2012, Jungreis et al., 2011, Wasbrough et al., 2010, Junion et al., 2007)

Name Synonyms

CG3754

CG42276

(FlyBase Genome Annotators, 2008)

Phosphodiesterase 9

(Day and Davies, 2003.6.10)

Secondary FlyBase IDs

FBgn0052648
FBgn0030424
FBgn0030426
FBgn0030427
FBgn0030428

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections