shs, l(2)00255, TSC-22, Dm_2L:60722
transcription factor - leucine zipper - Dpp pathway - mutation leads to a delay in differentiation and to a loss of photoreceptors - required for a morphogenetic movement in the brain - functions in wing margin development - required for both male and female fertility
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.49
Gene model reviewed during 5.43
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Gene model reviewed during 5.57
5.8, 2.8 (longest cDNA)
1212, 224 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bun using the Feature Mapper tool.
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
bun is expressed in mushroom body neurons during metamorphosis and is greatly reduced in adults. They are expressed in the alpha/beta neurons but not in alpha neurons or alpha'/beta' neurons.
GBrowse - Visual display of RNA-Seq signalsView Dmel\bun in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: bun CG5461
Source for merge of: bun CG31857
Annotations CG5461 and CG31857 merged as CG42281 in release 5.8 of the genome annotation.
New annotation (CG31857) in release 3 of the genome annotation.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Mutations in bun cause a delay in photoreceptor neural differentiation relative to dpp expression suggesting that bun may be required for the transmission of the dpp signal. bun has a role in inducing rotation of the second optic lobe. bun encodes a cytoplasmic protein expressed anterior to the furrow in a hh-dependent manner.