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Gene Dmel\Ir7d

General Information
Symbol	Dmel\Ir7d	Species	D. melanogaster
Name	Ionotropic receptor 7d	Annotation symbol	CG42294
Feature type	protein_coding_gene	FlyBase ID	FBgn0259190
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	CG15327, IR7d
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7C1-7C1	Sequence location	X:7,770,996..7,772,869 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 7d is referred to in FlyBase by the symbol Dmel\Ir7d (CG42294, FBgn0259190). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-gated ion channel activity. Based on sequence similarity, it is predicted to be involved in the biological process: detection of chemical stimulus. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. Peak expression observed within 06-18 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1636032_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir7d. Gene sequence location is X:7770996..7772869.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7C1-7C1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir7d for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene split based on protein alignment (BLASTX) data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir7d-RA FBtr0299674  NM_001144703   1785   594
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir7d-PA   FBpp0288952   67.4   594   9.25     NP_001138175   ACL82907
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 ACL82907
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	B7Z0Y1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.175 Larval Midgut    5.8 Larval Hindgut    1.4 Larval Malpighian Tubules    2.2 Larval Fat Body    8.4 Larval Salivary Gland    5 Larval Trachea    1.525 Larval Carcass    7.525 Adult Head    4 Adult Eye    2.3 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    2.6 Adult Midgut    1.8 Adult Hindgut    2.6 Adult Malpighian Tubules    3 Adult Fat Body    3.2 Adult Salivary Gland    9.6 Adult Heart    3.25 Adult VirginFemale Spermatheca    2.9 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    1.6 Adult Testis    2.4 Adult Male Accessory Gland    2.6 Adult Carcass    7.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4   NA  Eye    2.3   NA  Brain    3.6   4.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4   NA  Crop    2.6   5.8  Midgut    1.8   1.4  Hindgut    2.6   2.2  Malpighian Tubules    3   8.4  Fat Body    3.2   5  Salivary Gland    9.6   NA  Heart    3.25   1.525  Trachea    NA   NA  VirginFemale Spermatheca    2.9   NA  InseminatedFemale Spermatheca    4.5   NA  Ovary    1.6   NA  Testis    2.4   NA  Male Accessory Gland    2.6   7.525  Carcass    7.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259190 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15327-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Ir7d Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir7d Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process
CV term Evidence References
detection of chemical stimulus inferred from sequence or structural similarity with Ir92a (Benton et al., 2009)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase, 1992-) protein_coding_gene (FlyBase, 1992-)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir7d allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (17) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZS9NP Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6ZW467 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6ZS9NP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir7d     Drosophila simulans   Dsim\GD16143     Drosophila sechellia   Dsec\GM11969     Drosophila erecta   Dere\GG17607     Drosophila yakuba   Dyak\GE17505     Drosophila ananassae   Dana\GF21245     Drosophila mojavensis   Dmoj\GI16331     Drosophila grimshawi   Dgri\GH12121     Drosophila grimshawi   Dgri\GH12349     Drosophila grimshawi   Dgri\GH12370
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6ZW467)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002366 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008737 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006009 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007088 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012493 Y Tribolium castaneum Red flour beetle  Tcas\TC011167 Y Tribolium castaneum Red flour beetle  Tcas\TC011166 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR39C15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259190 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 7354416
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir7d CG42294 (Benton et al., 2009)
Source for database merge of
Additional comments	for split of: CG15327 (FlyBase Genome Annotators, 2008) Annotation CG15327 split into CG42292, CG42293 and CG42294 in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001144703 RefSeq (Proteins) • NP_001138175 DDBJ / EMBL / GenBank • ACL82907 Entrez Gene - A searchable database of RefSeq genes. • 7354416 UniProtKB/TrEMBL • B7Z0Y1
Other Crossreferences
Linkouts
	DRSC - Results from RNAi screens. • FBgn0259190 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259190 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15327-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259190 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 7354416 modMine - Data generated by the modENCODE project. • FBgn0259190
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG15327 (FamiliarityBreedsContempt, 1999.11, FlyBase, 1992-, Lasko, 1999.11) CG42294 (Croset et al., 2010, Benton et al., 2009, Sienski et al., 2012) DmelIR7d (Croset et al., 2010) Ir7d   IR7d (Benton et al., 2009, Croset et al., 2010)
Name Synonym	ionotropic receptor 7d (Benton et al., 2009) Ionotropic receptor 7d
Secondary FlyBase IDs
	FBan0015327 FBgn0029967
References ( 9 )
Research paper	Sienski et al., 2012, Cell 151(5): 964--980 Transcriptional silencing of transposons by piwi and maelstrom and its impact on chromatin state and gene expression. [FBrf0220033] Croset et al., 2010, PLoS Genet. 6(8): e1001064 Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Croset et al., 2010, PLoS Genet. 6(8): Supporting Information: Table S3. [FBrf0219605]
FlyBase analysis	FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.9 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.9 of the annotated D.melanogaster genome. [FBrf0204763] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]