FlyBase Gene Report: Dmel\Ir7d

General Information

Symbol

Dmel\Ir7d

Species

D. melanogaster

Name

Ionotropic receptor 7d

Annotation Symbol

CG42294

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259190

Gene Model Status

Current

Stock Availability

1 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:7,876,963..7,878,836 [-]

Recombination map

1-21

RefSeq locus

NC_004354 REGION:7876963..7878836

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ligand-gated ion channel activity

inferred from sequence model

(Benton et al., 2009)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus

inferred from sequence or structural similarity with FLYBASE:Ir92a; FB:FBgn0038789

(Benton et al., 2009)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Benton et al., 2009)

Gene Group (FlyBase)

DIVERGENT IONOTROPIC RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

DIVERGENT IONOTROPIC RECEPTORS -: Divergent Ionotropic Receptors (IR), members of the IR family of ligand-gated ion channels, are largely species-specific, with low amino acid sequence identity. Expressed in gustatory organs, they are believed to be taste receptors. (Adapted from FBrf0211681).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir7d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase, 1992-)

protein_coding_gene

(FlyBase, 1992-)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir7d-RA

FBtr0299674

NM_001144703

1785

594

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ir7d-PA

FBpp0288952

67.4

594

9.25

NP_001138175

ACL82907

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

AE014298 / ACL82907

UniProt

B7Z0Y1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir7d using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir7d-GAL4.C}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gustatory receptor neuron of larval abdomen

(Sánchez-Alcañiz et al., 2018)

gustatory receptor neuron of terminal organ

(Sánchez-Alcañiz et al., 2018)

gustatory system neuron | subset of terminal organ

(Croset et al., 2016)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir7d in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir7d

View exonic expression by tissue for Dmel\Ir7d

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259190

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG15327-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0259190

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir7d

Transgenic constructs containing regulatory region of Ir7d

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRID1

2 of 15

Yes

Hsap\GRID2

2 of 15

Yes

Hsap\GRIK3

2 of 15

Yes

Hsap\GRIN2C

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gria1

1 of 15

Yes

Mmus\Gria2

1 of 15

Yes

Mmus\Gria3

1 of 15

Yes

Mmus\Gria4

1 of 15

Yes

Mmus\Grid1

1 of 15

Yes

Mmus\Grid2

1 of 15

Yes

Mmus\Grik1

1 of 15

Yes

Mmus\Grik2

1 of 15

Yes

Mmus\Grik3

1 of 15

Yes

Mmus\Grik4

1 of 15

Yes

Mmus\Grik5

1 of 15

Yes

Mmus\Grin2a

1 of 15

Yes

Mmus\Grin2b

1 of 15

Yes

Mmus\Grin2c

1 of 15

Yes

Mmus\Grin2d

1 of 15

Yes

Mmus\Grin3a

1 of 15

Yes

Mmus\Grin3b

1 of 15

Yes

Rattus norvegicus (Norway rat) (13)

Rnor\Gria3

1 of 13

Yes

Rnor\Gria4

1 of 13

Yes

Rnor\Grid2

1 of 13

Yes

Rnor\Grik2

1 of 13

Yes

Rnor\Grik3

1 of 13

Yes

Rnor\Grik4

1 of 13

Yes

Rnor\Grik5

1 of 13

Yes

Rnor\Grin2a

1 of 13

Yes

Rnor\Grin2b

1 of 13

Yes

Rnor\Grin2c

1 of 13

Yes

Rnor\Grin2d

1 of 13

Yes

Rnor\Grin3a

1 of 13

Yes

Rnor\Grin3b

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (12)

Xtro\grik5-like.1

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (28)

Drer\si:ch211-251b21.1

2 of 15

Yes

Drer\si:dkey-183j2.10

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-6

2 of 15

Yes

Cele\glr-8

2 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905BJ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13650

Drosophila persimilis

Dper\GL14588

Drosophila willistoni

Dwil\GK27564

Drosophila mojavensis

Drosophila grimshawi

Drosophila grimshawi

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502ZN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022337

Musca domestica

House fly

Mdoa\17022338

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02RF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012404

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005921

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_19057

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (69)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-21

Cytogenetic map

7C1-7C1

Sequence location

X:7,876,963..7,878,836 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7C1-7C1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-21

(FlyBase, 2016)

1-21.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (1)

Bloomington

81220

w^*; Bl¹/CyO; P{Ir7d-GAL4.C}attP2/TM6B, Tb⁺

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259190

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

7354416

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ir7d CG42294

(Benton et al., 2009)

Source for database merge of

Additional comments

The Ir7d gene, one of 44 "divergent" ionotropic receptor genes in D. melanogaster, may have been derived from an ancestral ionotropic receptor gene by retroposition, and in some cases, subsequent gene duplication.

(Croset et al., 2010)

for split of: CG15327

(FlyBase Genome Annotators, 2008)

Annotation CG15327 split into CG42292, CG42293 and CG42294 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 14 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

7354416

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.