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Gene Dmel\Ir94e

General Information
Symbol	Dmel\Ir94e	Species	D. melanogaster
Name	Ionotropic receptor 94e	Annotation symbol	CG42298
Feature type	protein_coding_gene	FlyBase ID	FBgn0259194
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	CG17379, IR94e
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94F1-94F1	Sequence location	3R:19,231,231..19,233,124 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 94e is referred to in FlyBase by the symbol Dmel\Ir94e (CG42298, FBgn0259194). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-gated ion channel activity. Based on sequence similarity, it is predicted to be involved in the biological process: detection of chemical stimulus. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. , at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623140_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir94e. Gene sequence location is 3R:19231231..19233124.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94F1-94F1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir94e for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Gene split based on protein alignment (BLASTX) data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir94e-RA FBtr0299678  NM_001104415   1836   611
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir94e-PA   FBpp0288956   70.8   611   6.65     NP_001097885   AAF56134
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56134
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCM4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    1.7 Larval Hindgut    1.4 Larval Malpighian Tubules    3.1 Larval Fat Body    2.1 Larval Salivary Gland    2.6 Larval Trachea    0.6 Larval Carcass    1.7 Adult Head    1.2 Adult Eye    0.625 Adult Brain    2.8 Adult Thoracic-Abdominal Ganglion    1.2 Adult Crop    1 Adult Midgut    1.4 Adult Hindgut    4 Adult Malpighian Tubules    3.4 Adult Fat Body    1.2 Adult Salivary Gland    8.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    1.4 Adult Testis    2 Adult Male Accessory Gland    5.2 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.2   NA  Eye    0.625   NA  Brain    2.8   1.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.2   NA  Crop    1   1.7  Midgut    1.4   1.4  Hindgut    4   3.1  Malpighian Tubules    3.4   2.1  Fat Body    1.2   2.6  Salivary Gland    8.4   NA  Heart    1.95   0.6  Trachea    NA   NA  VirginFemale Spermatheca    2.7   NA  InseminatedFemale Spermatheca    0.8   NA  Ovary    1.4   NA  Testis    2   NA  Male Accessory Gland    5.2   1.7  Carcass    4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259194 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17379-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ir94eGD199 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Ir94e Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir94e Class Mutagen Stocks Known lesion Ir94eGD199 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process
CV term Evidence References
detection of chemical stimulus inferred from sequence or structural similarity with Ir92a (Benton et al., 2009)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase Genome Annotators, 2008) protein_coding_gene (FlyBase Genome Annotators, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir94e allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (18) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZGPXN Dipteran inclusive ortholog search EOG68D13B Insect inclusive ortholog search EOG6N2ZHS Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6ZGPXN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir94e     Drosophila simulans   Dsim\GD21016     Drosophila sechellia   Dsec\GM26504     Drosophila erecta   Dere\GG11204     Drosophila yakuba   Dyak\GE10371     Drosophila pseudoobscura pseudoobscura   Dpse\GA30048     Drosophila persimilis   Dper\GL13639     Drosophila willistoni   Dwil\GK14114     Drosophila virilis   Dvir\GJ24103     Drosophila mojavensis   Dmoj\GI22052     Drosophila mojavensis   Dmoj\GI22053     Drosophila grimshawi   Dgri\GH20022     Drosophila grimshawi   Dgri\GH19650
Orthologs in non-Drosophila Dipterans (EOG68D13B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009661   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001527   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001529   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002010
Orthologs in non-Dipteran Insects (EOG6N2ZHS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005798 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v33066 w1118; P{GD199}v33066
Genomic Clones ( 1 )
	BACR15B19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259194 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42765
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir94e CG42298 (Benton et al., 2009)
Source for database merge of
Additional comments	Source for split of: CG17379 (FlyBase Genome Annotators, 2008) Annotation CG17379 split into CG42297 and CG42298 in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001104415 RefSeq (Proteins) • NP_001097885 DDBJ / EMBL / GenBank • AAF56134 Entrez Gene - A searchable database of RefSeq genes. • 42765 UniProtKB/TrEMBL • Q9VCM4
Other Crossreferences
Linkouts
	DRSC - Results from RNAi screens. • FBgn0259194 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259194 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17379-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259194 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42765 modMine - Data generated by the modENCODE project. • FBgn0259194
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG17379 (Dickson et al., 2007.7.18, FlyBase Genome Annotators, 2008) CG42298 (Benton et al., 2009, Croset et al., 2010) DmelIR94e (Croset et al., 2010) Ir94e   IR94e (Benton et al., 2009, Croset et al., 2010)
Name Synonym	ionotropic receptor 94e (Benton et al., 2009) Ionotropic receptor 94e
Secondary FlyBase IDs
	FBan0017379 FBgn0039076
References ( 7 )
Research paper	Croset et al., 2010, PLoS Genet. 6(8): e1001064 Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Croset et al., 2010, PLoS Genet. 6(8): Supporting Information: Table S3. [FBrf0219605] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.9 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.9 of the annotated D.melanogaster genome. [FBrf0204763]