• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\prom

General Information
Symbol	Dmel\prom	Species	D. melanogaster
Name	prominin	Annotation symbol	CG42310
Feature type	protein_coding_gene	FlyBase ID	FBgn0259210
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	eyc
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60C8-60C8	Sequence location	2R:20,302,931..20,315,910 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene prominin is referred to in FlyBase by the symbol Dmel\prom (CG42310, FBgn0259210). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: rhabdomere development. 12 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; tergite; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Prominin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 2R:20302931..20315910.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN32041 BKN27046 BKN30490 HFA04684
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60C8-60C8   Limits computationally determined from genome sequence between P{PZ}bs03267&P{lacW}l(2)k10502k10502 and P{lacW}Nurf-38k16102
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\prom for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) prom-RB FBtr0299698  NM_001144281   3870   1066 prom-RC FBtr0299699  NM_166671   3242   911 prom-RD FBtr0299700  NM_001144282   4377   1235
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein prom-PB   FBpp0288976   118.9   1066   6.62     NP_001137753   ACL83206 prom-PC   FBpp0288977   101.3   911   7.60     NP_726444   AAM68313 prom-PD   FBpp0288978   138.3   1235   8.11     NP_001137754   ACL83207
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prominin (IPR008795)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAM68313   AE013599 ACL83206   AE013599 ACL83207   AI062936   AI062937   AI534184   BT022433   BT022454   BT029279   CL526003   CO264817   CO266389   CO304059   CO312176   CO317996   CO326408   CO327452   DQ780943 ABH07113   EC064805   EC089544   EC199054   EC200184   EC213555   EC220213   EC222038   EC227295   EC233005   EC250025   EC255718   EC259031   EL875009   EL876010   EL876011   EL883108   EL883235   EL883462   EL883700   EL883800   EL883919
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLN9 Q06PM6 B7YZQ3 A0AVW1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259210    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259210 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259210 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP  (801) pupae 3d postWPP  (2411) pupae 4d postWPP  (841) adult male 01day  (437) adult male 05day  (473) adult male 30day  (444) adult female 01day  (242) adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP  (2411) pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259210 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP  (801) pupae 3d postWPP  (2411) pupae 4d postWPP  (841) adult male 01day  (437) adult male 05day  (473) adult male 30day  (444) adult female 01day  (242) adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP  2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    12 larva L2    11 larva L3 12hr old    7 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    6 white prepupae 12hr    50 white prepupae 24hr    56 pupae 2d postWPP    801 pupae 3d postWPP    2411 pupae 4d postWPP    841 adult male 01day    437 adult male 05day    473 adult male 30day    444 adult female 01day    242 adult female 05day    84 adult female 30day    63 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259210    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259210 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259210 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30164-RA;CG30166-RA;CG30165-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable prom1 prom04012b promEY08306 viable, with Scer\GAL4pnr-MD237 promGD2205 promGD2206 promGD5120 Sterility Allele fertile promEY08306 Other Phenotypes Allele visible prom04012b Phenotype manifest in Allele ommatidium prom1 rhabdomere prom04012b prom1 rhabdomere (with Df(2R)Px2) prom04012b tergite prom04012b
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of prom Class Mutagen Stocks Known lesion prom04012b P-element activity 1 Yes promEY08306 P-element activity 1 -- promKG00697 1 -- promKG02814 1 -- promMB02637 1 -- prom1 loss of function allele 0 Yes prom2 loss of function allele 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of prom Class Mutagen Stocks Known lesion promGD2206 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes promGD5120 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes promGD2205 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes promKK112041 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes promScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6278 (Ryder, 2004.4.26) Df(2R)Exel7185 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2206} NA P{KK112041} NA P{UAS-prom.Z} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}promKG00697 NA P{SUPor-P}promKG02814 NA insertion of mobile activating element P{EPgy2}promEY08306 NA insertion of enhancer trap binary system Mi{ET1}promMB02637 No insertion of enhancer trap P{PZ}prom04012b No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
rhabdomere development inferred from mutant phenotype (Zelhof et al., 2006, Sang and Ready, 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR008795 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions prom allele Gene References unspecified chp (Zelhof et al., 2006) eys (Zelhof et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0259210
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11251 Dana\GF11252 Dana\GF11254 Dere\GG16521 Dere\GG19934 Dere\GG19935 Dgri\GH20897 Dgri\GH20900 Dgri\GH20901 Dmoj\GI18907 Dmoj\GI18909 Dmoj\GI18910 Dper\GL20441 Dper\GL20447 Dper\GL20448 Dpse\GA15690 Dpse\GA15691 Dpse\GA25610 Dsec\GM11837 Dsec\GM11838 Dsec\GM19498 Dsim\GD17869 Dsim\GD24958 Dsim\GD24959 Dvir\GJ20731 Dvir\GJ20733 Dvir\GJ20735 Dwil\GK19346 Dwil\GK19689 Dwil\GK19690 Dyak\GE11461 Dyak\GE11463 Dyak\GE11464
Curated drosophilid orthologs	Dpse\GA15690   Dpse\GA15691   Dpse\GA15692
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003441-PA Aedes aegypti (mosquito) ENSBTAP00000002536 Bos taurus (bovine) CPIJ008251 Culex pipens (mosquito) ENSCPOP00000005501 Cavia porcellus (guinea pig) 227753 Capitella spl (polychaete worm) ENSECAP00000013331 Equus caballus (horse) ENSGALP00000023357 Gallus gallus (chicken) ENSP00000318520 Homo sapiens (human) 175163 Lottia gigantea (owl limpet) XP_001605448.1 Nasonia vitripennis (wasp) ENSORLP00000010512 Oryzias latipes (japanese killifish) ENSPPYP00000013441 Pongo pygmaeus (orangutan) ENSPTRP00000020936 Pan troglodytes (chimpanzee) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12713 LH17288 FBgn0229269 FBgn0229268 FBgn0221688 FBgn0221687 FBgn0207873 FBgn0207871 FBgn0196272 FBgn0196271 FBgn0166778 FBgn0166779 FBgn0075708 FBgn0075707 FBgn0158043 FBgn0158042 FBgn0141649 FBgn0141648 FBgn0128363 FBgn0128362 FBgn0112135 FBgn0112134 FBgn0088292 FBgn0088291 CPIJ008251 BGIBMGA011558 ACYPI40356 GB16040 AGAP011954 AAEL003441 PB25419 PB25420 GLEAN_00368
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	23453 w1118; Mi{ET1}promMB02637 17450 y1 w67c23; P{EPgy2}promEY08306 12922 y1 w67c23; P{SUPor-P}promKG02814 13691 y1 w67c23; P{SUPor-P}promKG00697 11363 cn1 P{PZ}prom04012b, l(2)04012a04012a/CyO; ry506
VDRC	v106533 P{KK112041}VIE-260B v3631 w1118; P{GD2206}v3631 v3633 w1118; P{GD2206}v3633 v37854 w1118; P{GD5120}v37854 v19709 w1118; P{GD2205}v19709/CyO v37855 w1118; P{GD5120}v37855/TM3
Genomic Clones ( 1 )
	BACR02A05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05688 IP05788 IP13255
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02321 GH02322
Other clones	31245 35525 37604 57129 101456 163832 165304 173808 214257.41 214543.67 CK01.131B.G11 EK140412 EK146227 EK228019 EK243540 EK269958 EP03849 EP07140 IP05888 IP12837 IP12937 IP13137 IP13355 IP13455 IP13555 IP15056 SD06723
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259210 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246493 246494 246495
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: prom CG30165 CG30166 (FlyBase Genome Annotators, 2008)
Additional comments	Annotations CG30164, CG30165 and CG30166 merged as CG42310 (which corresponds to prom) in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008) The symbol "CG4556" has been used erroneously in FlyBase to name 2 separate annotations in different releases of the genome annotation. The release 2 annotation "CG4556" was split into 3 separate annotations (CG4556, CG30164, CG30165) in release 3 of the genome annotation, but one of these annotations mistakenly retained the "CG4556" label instead of being given a new annotation number. Annotations CG30164, CG30165 and CG30166 were subsequently merged as CG42310 (which corresponds to prom) in release 5.9 of the genome annotation. The annotation labelled "CG4556" in release 3 of the genome annotation has been renamed to CG42383 in release 5.10 of the genome annotation to avoid confusion. The CG42383 annotation lies within an intron of the CG42310 annotation in release 5.10 of the genome annotation. (FlyBase Genome Annotators, 2008) The previous identification of CG42383 as the transcript responsible for the "eyes closed (eyc)" phenotype (FBrf0141505) was in error; the prom04012b and prom2 mutants previously referred to as "eyc" mutations map to the prom transcript. (Zelhof, 2006) Source for split of: CG4556 (FlyBase Genome Annotators, 2002-2003) Annotation CG4556 split into CG4556, CG30164, CG30165 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) FlyBase curator comment: in FBrf0141505, the "eyes closed (eyc)" complementation group is stated to correspond to the CG42383 annotation. However, FBrf0198649 shows that the prom04012b and prom2 mutants (referred to as "eycP" and "eyc1" respectively in FBrf0198649) map to the prom transcription unit (CG42383 maps within an intron of prom). These two alleles are thus listed as alleles of prom in FlyBase. The "UAS-eyc" construct (P{UAS-eyc.S}) described in FBrf0141505 contains the CG42383 open reading frame and is thus associated with the CG42383 gene in FlyBase. The "eyc" synonym thus appears under both the prom and CG42383 genes in FlyBase. (FlyBase, 1996-)
Other Comments
	eys and prom define two independent steps in interrhabdomeral space formation. (Husain et al., 2006) The presence of the prom protein in eyes ensures that the rhabdomere is surrounded by a crescent of eys protein. (Zelhof, 2006) New annotation (CG30166) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166671 NM_001144281 NM_001144282 RefSeq (Proteins) • NP_726444 NP_001137753 NP_001137754 DDBJ / EMBL / GenBank • AAM68313 ABH07113 ACL83206 ACL83207 AI062937 CL526003 DQ780943 Entrez Gene - A searchable database of RefSeq genes. • 246493 UniProtKB/TrEMBL • A0AVW1 B7YZQ3 Q06PM6 Q8MLN9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prominin (IPR008795)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0259210 DRSC - Results from RNAi screens. • FBgn0259210 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259210 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30164-RA;CG30166-RA;CG30165-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259210 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246493 246494 246495 InParanoid A subset of ortholog calls from InParanoid. • AAEL003441-PA Aedes aegypti (mosquito) ENSBTAP00000002536 Bos taurus (bovine) CPIJ008251 Culex pipens (mosquito) ENSCPOP00000005501 Cavia porcellus (guinea pig) 227753 Capitella spl (polychaete worm) ENSECAP00000013331 Equus caballus (horse) ENSGALP00000023357 Gallus gallus (chicken) ENSP00000318520 Homo sapiens (human) 175163 Lottia gigantea (owl limpet) XP_001605448.1 Nasonia vitripennis (wasp) ENSORLP00000010512 Oryzias latipes (japanese killifish) ENSPPYP00000013441 Pongo pygmaeus (orangutan) ENSPTRP00000020936 Pan troglodytes (chimpanzee) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/eyeclsd1.htm modMine - Data generated by the modENCODE project. • FBgn0259210 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12713 LH17288 FBgn0229269 FBgn0229268 FBgn0221688 FBgn0221687 FBgn0207873 FBgn0207871 FBgn0196272 FBgn0196271 FBgn0166778 FBgn0166779 FBgn0075708 FBgn0075707 FBgn0158043 FBgn0158042 FBgn0141649 FBgn0141648 FBgn0128363 FBgn0128362 FBgn0112135 FBgn0112134 FBgn0088292 FBgn0088291 CPIJ008251 BGIBMGA011558 ACYPI40356 GB16040 AGAP011954 AAEL003441 PB25419 PB25420 GLEAN_00368
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG4556   CG30164   CG30165   CG30166 (Keleman et al., 2009.8.5) CG42310 (FlyBase Genome Annotators, 2008, FlyBase Genome Annotators, 2008) eyc (Stewart, 2002, Sang and Ready, 2002, Husain et al., 2006) prom (Zelhof, 2008.6.16, Zelhof et al., 2006, Zelhof, 2006)
Name Synonym	eyes closed (Sang and Ready, 2002) prominin (Zelhof, 2008.6.16, Zelhof et al., 2006, Zelhof, 2006, Cook et al., 2008) Prominin (Moses, 2006)
Secondary FlyBase IDs
	FBgn0027659 FBgn0050164 FBgn0050165 FBgn0050166
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 7 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 1 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...