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Gene Dmel\cno

General Information
Symbol	Dmel\cno	Species	D. melanogaster
Name	canoe	Annotation symbol	CG42312
Feature type	protein_coding_gene	FlyBase ID	FBgn0259212
Gene Model Status	Current	Stock availability	24 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-49
Cytogenetic map	82F4-82F6	Sequence location	3R:998,392..1,043,147 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene canoe is referred to in FlyBase by the symbol Dmel\cno (CG42312, FBgn0259212). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: embryonic morphogenesis; dorsal closure; regulation of JNK cascade; epidermis morphogenesis; compound eye development; ommatidial rotation. 54 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; histaminergic neuron; organ system; extended germ band embryo; head mesoderm; cell part; adherens junction; acellular anatomical structure; rhabdomere; primary pigment cell; cell junction. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Dil domain; Dilute; Forkhead-associated (FHA) domain; PDZ/DHR/GLGF; Ras-association; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult ovary. Gene sequence location is 3R:998392..1043147.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cno: canoe Homozygous lethal; dorsal surface of embryo open.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Bothma et al., 2011, Curr. Biol. 21(18): 1571--1577 Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Sela et al., 2010, Genome Biol. 11(6): R59 Sequence features HFA12054 BKN22788 HFA12374 BKN32164
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82F4-82F6   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82E-82F   (determined by in situ hybridisation)   (Miyamoto et al., 1995)
Experimentally Determined Recombination Data
Location	3-49 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cno for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data. Due to an oversight in the implementation of gene annotation merges, the symbols for some of the transcripts and polypeptides of this gene were changed to non-unique designations in r5.9. Although there were no conflicts within a given release, the same symbols were used for different isoforms in different releases. The affected gene product symbols have now been changed to symbols not used previously in the database; see individual transcript reports for details. No evidence for 13aa QQQRYLGQSLPAE from SWP:Q24279 in the 18th exon of this gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cno-RC FBtr0299709  NM_169025   7381   1882 cno-RD FBtr0299710  NM_169026   6053   1817 cno-RE FBtr0300525  NM_079508   6956   2051
Additional Transcript Data & Comments
Reported size (kB)	8.2, 7.5, 7.0 (northern blot) (Miyamoto et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cno-PC   FBpp0288987   208.9   1882   7.83     NP_730891   AAN13260 cno-PD   FBpp0288988   200.5   1817   7.78     NP_730892   AAN13261 cno-PE   FBpp0289752   226.9   2051   7.23     NP_524232   AAF52067
Additional Polypeptide Data & Comments
Reported size (kDa)	1893 (aa); 200 (kD observed) (Miyamoto et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dil domain (IPR018444) Ras-association (IPR000159) Forkhead-associated (FHA) domain (IPR000253) PDZ/DHR/GLGF (IPR001478) Dilute (IPR002710) SMAD/FHA domain (IPR008984)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141038   AA141039   AA201201   AA201567   AA439349   AA539505   AA539680   AA695531   AA820744   AA949987   AA950976   AA978718   AA979465   AE014297 AAF52067   AE014297 AAN13260   AE014297 AAN13261   AI064681   AI106613   AI455059   AI455559   AI456631   AI515006   AI519335   AI519787   AW942708   AX260085   AY058547 AAL13776   BG632080   BI353144   BP546430   BP553473   BP553474   BT025933   BT044227   CA804713   CK132823   CO187651   CO190218   CO268448   CO271095   CO277118   CO286594   CO286812   CO294853   CO304625   CO307424   CO310656   CO311930   CO314856   CO318026   CO321561   CO332684   CO342672   CO344437   CZ466610   CZ467575   CZ469173   CZ473386   CZ473560   CZ473561   CZ479347   CZ479348   CZ480644   CZ480645   CZ482992   CZ484174   CZ484438   CZ485676   CZ489704   CZ489705   D49534 BAA08478   EC082493   EC082827   EC090555   EC090655   EC206990   EC209130   EC211813   EC211914   EC212915   EC213005   EC213453   EC225427   EC225896   EC229970   EC236965   EC238074   EC249964   EC252331   EL883829   EV592084   EV593573
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24279 Q8IPP4 Q95TT5 Q9VN82 Q8IPP3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epidermis   (Feinstein et al., 1995) embryonic stage 3   epithelial cell   • cortical cytoskeleton (Lecuyer et al., 2007) Comment:within polygonal cortical network epithelium   • cortical cytoskeleton (Lecuyer et al., 2007) Comment:within polygonal cortical network embryonic stage 5   organism | striped   (Miyamoto et al., 1995) organism | restricted   (Miyamoto et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Miyamoto et al., 1995) embryonic stage 5   organism | ubiquitous   (Miyamoto et al., 1995) embryonic stage 7 -- 10   posterior embryonic/larval midgut   (Miyamoto et al., 1995) embryonic stage 10   ectoderm   (Miyamoto et al., 1995) embryonic stage 13   embryonic/larval proventriculus   (Miyamoto et al., 1995) larval stage   eye-antennal disc   (Miyamoto et al., 1995)
Additional Descriptive Data
	In wild type embryos, cno transcripts are expressed in dorsal-ventral oriented rows of cells in the posterior portion of each thoracic and abdominal segment. cno was shown to be induced by ubiquitous Ubx expression. cno expression in various homeotic mutant backgrounds was also described. (Feinstein et al., 1995) cno transcripts are most abundant in embryos, decrease in larvae, and increase again in pupae and adults. The relative abundance of the three transcript species varies with developmental stage. In early stage 5 embryos, a low uniform level of cno transcripts is seen. At the cellular blastoderm stage, expression is seen along the dorsal midline and in three ectodermal stripes in the central region of the embryo. During stages 7-10, expression is confined to the dorsal furrows and the posterior midgut rudiment. Ectodermal expression becomes evident in stage 10. In stage 13, focal stainings are detected near the attachment site of the midgut with the foregut and hindgut. In eye discs, cno is expressed ubiquitously with a higher concentration of transcripts in the lateral edge region. (Miyamoto et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immuno-electron microscopy Stage Tissue/Position (including subcellular localization) Reference P-stage   photoreceptor cell   • adherens junction of internal side of plasma membrane of rhabdomere (Matsuo et al., 1999) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   lateral ectoderm   • adherens junction (Kutchma et al., 2007) embryonic stage 15   amnioserosa   (Matsuo et al., 1999) P-stage   photoreceptor cell   • adherens junction of rhabdomere (Matsuo et al., 1999) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Matsuo et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259212    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259212 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259212 expression level Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3688) embryo 02-04hr  (4663) embryo 04-06hr  (3344) embryo 06-08hr  (3670) embryo 08-10hr  (3467) embryo 10-12hr  (1721) embryo 12-14hr  (2282) embryo 14-16hr  (3390) embryo 16-18hr  (2659) embryo 18-20hr  (1644) embryo 20-22hr  (2441) embryo 22-24hr  (2063) larva L1  (665) larva L2  (561) larva L3 12hr old  (366) larva L3 puffstage 1-2  (279) larva L3 puffstage 3-6  (742) larva L3 puffstage 7-9  (913) white prepupae new  (1121) white prepupae 12hr  (959) white prepupae 24hr  (1564) pupae 2d postWPP  (1243) pupae 3d postWPP  (1176) pupae 4d postWPP  (690) adult male 01day  (715) adult male 05day  (651) adult male 30day  (667) adult female 01day  (1459) adult female 05day  (2267) adult female 30day  (2414) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3688) embryo 02-04hr  (4663) embryo 04-06hr  (3344) embryo 06-08hr  (3670) embryo 08-10hr  (3467) embryo 10-12hr  (1721) embryo 12-14hr  (2282) embryo 14-16hr  (3390) embryo 16-18hr  (2659) embryo 18-20hr  (1644) embryo 20-22hr  (2441) embryo 22-24hr  (2063) larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr  (1564) pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day  1459 adult female 05day  (2267) adult female 30day  (2414) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259212 expression level Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3688) embryo 02-04hr  (4663) embryo 04-06hr  (3344) embryo 06-08hr  (3670) embryo 08-10hr  (3467) embryo 10-12hr  (1721) embryo 12-14hr  (2282) embryo 14-16hr  (3390) embryo 16-18hr  (2659) embryo 18-20hr  (1644) embryo 20-22hr  (2441) embryo 22-24hr  (2063) larva L1  (665) larva L2  (561) larva L3 12hr old  (366) larva L3 puffstage 1-2  (279) larva L3 puffstage 3-6  (742) larva L3 puffstage 7-9  (913) white prepupae new  (1121) white prepupae 12hr  (959) white prepupae 24hr  (1564) pupae 2d postWPP  (1243) pupae 3d postWPP  (1176) pupae 4d postWPP  (690) adult male 01day  (715) adult male 05day  (651) adult male 30day  (667) adult female 01day  (1459) adult female 05day  (2267) adult female 30day  (2414) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3688) embryo 02-04hr  (4663) embryo 04-06hr  (3344) embryo 06-08hr  (3670) embryo 08-10hr  (3467) embryo 10-12hr  1721 embryo 12-14hr  2282 embryo 14-16hr  (3390) embryo 16-18hr  (2659) embryo 18-20hr  1644 embryo 20-22hr  2441 embryo 22-24hr  2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr  1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day  1459 adult female 05day  2267 adult female 30day  2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3688 embryo 02-04hr    4663 embryo 04-06hr    3344 embryo 06-08hr    3670 embryo 08-10hr    3467 embryo 10-12hr    1721 embryo 12-14hr    2282 embryo 14-16hr    3390 embryo 16-18hr    2659 embryo 18-20hr    1644 embryo 20-22hr    2441 embryo 22-24hr    2063 larva L1    665 larva L2    561 larva L3 12hr old    366 larva L3 puffstage 1-2    279 larva L3 puffstage 3-6    742 larva L3 puffstage 7-9    913 white prepupae new    1121 white prepupae 12hr    959 white prepupae 24hr    1564 pupae 2d postWPP    1243 pupae 3d postWPP    1176 pupae 4d postWPP    690 adult male 01day    715 adult male 05day    651 adult male 30day    667 adult female 01day    1459 adult female 05day    2267 adult female 30day    2414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259212    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259212 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259212 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31537-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage cno2 lethal | embryonic stage | germline clone cnoR2 lethal | embryonic stage | heat sensitive cno1 lethal | embryonic stage | partially (with cno2) cnomis1 lethal | embryonic stage | partially (with cnomis1) cno2 lethal | embryonic stage | recessive cnounspecified lethal | recessive cnoC16 cnoC87 cnoC167 cnoC670 cnoC1087 cnoC1309 cnoC1460 cnol4 cnol13 cnol35 cnomis10 cnoT1 cnoT23 cnoT33 cnoT42 cnoT44 viable, with Scer\GAL4pnr-MD237 cnoGD1395 Other Phenotypes Allele cell polarity defective cnomis1 cell polarity defective, with Scer\GAL4HLHmδ.0.5 cnoScer\UAS.cMa cell polarity defective (with cno2) cnomis1 cell polarity defective (with cnomis1) cno2 planar polarity defective | embryonic stage cnoR2 visible cnomis1 visible (with cno2) cnomis1 visible (with cnomis1) cno2 visible | recessive cno2 cnomis1 Phenotype manifest in Allele adherens junction cnoR2 cone cell cno3 cnomis1 cone cell, with Scer\GAL4hs.2sev cnoScer\UAS.cMa dorsal closure embryo cno2 dorsal closure embryo, with Scer\GAL4ptc-559.1 cnoScer\UAS.cBa dorsal closure embryo (with cno2) cnomis1 dorsal closure embryo (with cnomis1) cno2 embryo | dorsal cnounspecified embryo | dorsal closure stage | germline clone cnoR2 embryonic/first instar larval cuticle cnoR2 embryonic/first instar larval cuticle | dorsal cno3 embryonic dorsal epidermis cno1 cnounspecified eye cno2 cnomis1 eye | somatic clone cnomis10 eye photoreceptor cell cnomis1 eye photoreceptor cell, with Scer\GAL4hs.2sev cnoScer\UAS.cMa eye photoreceptor cell (with cno2) cnomis1 eye photoreceptor cell (with cnomis1) cno2 eye photoreceptor cell | somatic clone cnomis10 head mesoderm cnoR2 macrochaeta & postpronotum cnomis1 macrochaeta & scutellum cnomis1 macrochaeta & scutum cnomis1 macrochaeta & wing cnomis1 mesectoderm cnoR2 ommatidium cnomis1 ommatidium, with Scer\GAL4HLHmδ.0.5 cnoScer\UAS.cMa ommatidium (with cno2) cnomis1 ommatidium (with cnomis1) cno2 ommatidium | somatic clone cnomis10 photoreceptor cell R1, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R2, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R3, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R4, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R5, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R6, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R7 cnomis1 photoreceptor cell R7, with Scer\GAL4hs.2sev cnoScer\UAS.cMa photoreceptor cell R8 cnomis1 pigment cell cno3 cnomis1 primary pigment cell cnomis1 retina cnomis1 rhabdomere cnohs.PM cnomis1 rhabdomere, with Scer\GAL4hs.2sev cnoScer\UAS.cMa rhabdomere R1 & microvillus cnomis1 rhabdomere R2 cnomis1 rhabdomere R3 cnomis1 rhabdomere R4 & microvillus cnomis1 stage 14 embryo (with cno2) cnomis1 stage 14 embryo (with cnomis1) cno2
Classical Alleles ( 45 )
For All Classical Alleles Show
Allele of cno Class Mutagen Stocks Known lesion cno2 ethyl methanesulfonate 2 -- cnomis1 hypomorphic allele - genetic evidence Delta2-3 2 Yes cnomis10 amorphic allele - genetic evidence Delta2-3 1 Yes cno3 ethyl methanesulfonate 1 -- cnoc00629 piggyBac transposase 1 -- cnoc01949 piggyBac transposase 1 -- cnoc04321 piggyBac transposase 1 -- cnoC156 1 -- cnoC670 1 -- cnod03468 P-element activity 1 -- cnod03792 P-element activity 1 -- cnoe01534 piggyBac transposase 1 -- cnoe02872 piggyBac transposase 1 -- cnoEY13916 P-element activity 1 -- cnof00529 piggyBac transposase 1 -- cnof01707 piggyBac transposase 1 -- cnof01937 piggyBac transposase 1 -- cnof03124 piggyBac transposase 1 -- cnoMI00782 1 -- cno009105 P-element activity 0 Yes cno1 ethyl methanesulfonate 0 -- cnoC1087 0 -- cnoC1309 0 -- cnoC1460 0 -- cnoC167 0 -- cnoC16 0 -- cnoC87 0 -- cnoCB-5577-3 0 -- cnoCPTI000590 piggyBac transposase 0 Yes cnod06831 0 -- cnof01663 0 -- cnof06962 piggyBac transposase 0 -- cnol13 0 -- cnol35 0 -- cnol4 0 -- cnomisr13 Delta2-3 0 Yes cnoR10 ethyl methanesulfonate 0 Yes cnoR2 ethyl methanesulfonate 0 Yes cnoT1 0 -- cnoT23 hypomorphic allele - genetic evidence 0 -- cnoT33 hypomorphic allele - genetic evidence 0 -- cnoT42 0 -- cnoT44 hypomorphic allele - genetic evidence 0 -- cnots 0 -- cnounspecified ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cno Class Mutagen Stocks Known lesion cnoGD1395 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnoHMS00239 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnoKK112164 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnoGD10288 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cnohs.PM in vitro construct - regulatory fusion 0 Yes cnoRA1mut+RA2mut.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes cnoScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes cnoScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes cnoΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)6-7 (Megraw and Kaufman, 1998.10.2, Miyamoto et al., 1995, Matsuo et al., 1997) Df(3R)110 (Megraw and Kaufman, 1998.10.2) Df(3R)ED5147 (Roote, 2004.7.20, Ryder and Roote, 2004.11.10)
Not disrupted in	Df(3R)3-4 (Megraw and Kaufman, 1998.10.2, Miyamoto et al., 1995) Df(3R)107 (Megraw and Kaufman, 1998.10.2) Df(3R)ED5156 (Ryder and Roote, 2004.11.10) Df(3R)Z1 (Megraw and Kaufman, 1998.10.2, Miyamoto et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1395} NA P{KK112164} NA P{TRiP.HMS00239} NA P{UAS-cno.B} NA P{UAS-cno.RA1*+RA2*} NA P{UAS-cno.ΔN} NA P{UAS-cno} NA heat-shock construct P{hs-cno.M} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}cnoEY13916 NA P{XP}cnod03468 NA P{XP}cnod03792 NA P{XP}cnod06831 NA miscellaneous insertions Mi{MIC}cnoMI00782 NA P{BmΔ-w}cnomis1 NA P{RS3}cnoCB-5577-3 NA PBac{3HPy+}cnoC156 NA PBac{602.P.SVS-1}cnoCPTI000590 NA PBac{PB}cnoc00629 NA PBac{PB}cnoc01949 NA PBac{PB}cnoc04321 NA PBac{RB}cnoe01534 NA PBac{RB}cnoe02872 NA PBac{WH}cnof00529 NA PBac{WH}cnof01663 NA PBac{WH}cnof01707 NA PBac{WH}cnof01937 NA PBac{WH}cnof03124 NA PBac{WH}cnof06962 NA insertion of enhancer trap P{lacW}cno009105 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye development inferred from genetic interaction with mbt (Menzel et al., 2007) dorsal closure inferred from mutant phenotype (Boettner et al., 2003) embryonic morphogenesis inferred from mutant phenotype (Sawyer et al., 2009) epidermis morphogenesis inferred from mutant phenotype (Sawyer et al., 2009) ommatidial rotation inferred from mutant phenotype (Gaengel and Mlodzik, 2003) regulation of JNK cascade inferred from genetic interaction with bsk AND inferred from mutant phenotype (Boettner et al., 2003)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Matsuo et al., 1999) cell cortex inferred from direct assay (Denholm et al., 2005) connecting hemi-adherens junction inferred from direct assay (Sawyer et al., 2009)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity with EMBL:U83231 (FlyBase, 1992-)
Biological Process
CV term Evidence References
dorsal closure traceable author statement (Noselli and Agnes, 1999, Tepass et al., 2001) dorsal closure, elongation of leading edge cells non-traceable author statement (Harden, 2002) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) JNK cascade non-traceable author statement (Noselli and Agnes, 1999) Notch signaling pathway traceable author statement (Tepass et al., 2001) Ras protein signal transduction traceable author statement (Tepass et al., 2001) regulation of JNK cascade non-traceable author statement (Harden, 2002)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Humbert et al., 2003) traceable author statement (Noselli and Agnes, 1999, Liu and Lengyel, 2000) zonula adherens traceable author statement (Tepass et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cno allele Gene References cno2 bsk (Boettner et al., 2003) R (Boettner et al., 2003) S (Gaengel and Mlodzik, 2003) cno3 bsk (Takahashi et al., 1998) H (Johannes and Preiss, 2002) hep (Takahashi et al., 1998) Ras64B (Matsuo et al., 1997) Ras85D (Matsuo et al., 1997) S (Gaengel and Mlodzik, 2003) cnomis1 bsk (Takahashi et al., 1998) hep (Takahashi et al., 1998) mys (Miyamoto et al., 1995) N (Miyamoto et al., 1995) pyd (Takahashi et al., 1998) R (Boettner et al., 2003) sgg (Miyamoto et al., 1995) cnoScer\UAS.cBa R (Boettner et al., 2003) unspecified dsh (Yamamoto et al., 1997) N (Yamamoto et al., 1997) sca (Miyamoto et al., 1995) sgg (Yamamoto et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65834 DroID - A comprehensive database of gene and protein interactions. • FBgn0259212 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40620
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA15389   Dpse\GA16311
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004393-PA Aedes aegypti (mosquito) AGAP004039-PA Anopheles gambiae (mosquito) XP_393645.3 Apis mellifera (honey bee) XP_001944877.1 Acyrthosiphon pisum (pea aphid) 208117 Branchiostoma floridae (lancelet) XP_001893791.1 Brugia malayi (roundworm nematode) BGIBMGA004697-PA Bombyx mori (silk worm) ENSBTAP00000007309 Bos taurus (bovine) CN00780 Caenorhabditis brenneri (small nematode) CBP34462 Caenorhabditis briggsae (nematode) CE26729 Caenorhabditis elegans (worm) ENSCAFP00000001228 Canis familiaris (dog) JA12672 Caenorhabditis japonica (nematode) CPIJ007708 Culex pipens (mosquito) ENSCPOP00000007433 Cavia porcellus (guinea pig) RP27709 Caenorhabditis remanei (nematode) ENSCSAVP00000017818 Ciona savignyi (sedentary tunicate) 316993 Daphnia pulex (daphnia) ENSDARP00000039753 Danio rerio (zebra fish) ENSECAP00000012677 Equus caballus (horse) ENSGALP00000018461 Gallus gallus (chicken) 184008 Hypsipyla robusta (cedar shoot borer) ENSP00000345834 Homo sapiens (human) ISCW019802-PA Ixodes scapularis (deer tick) 210615 Lottia gigantea (owl limpet) ENSMODP00000007516 Monodelphis domestica (gray opossum) ENSMMUP00000027697 Macaca mulatta (rhesus monkey) 174672 Nematostella vectensis (starlet anemone) XP_001605722.1 Nasonia vitripennis (wasp) ENSOANP00000009340 Ornithorynchus anatinus (platypus) PHUM002453-PA Pediculus humanus (human body louse) ENSPPYP00000019236 Pongo pygmaeus (orangutan) ENSPTRP00000049438 Pan troglodytes (chimpanzee) ENSRNOP00000048254 Rattus norvegicus (norway rat) Smp_164340 Schistosoma mansoni (trematode parasite) XP_794644.2 Strongylocentrotus purpuratus (purple sea urchin) 170 Trichoplax adhaerens (metazoa) XP_971214.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022337 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014198 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11000 NV11659 LH16941 ISCW019802 FBgn0242386 FBgn0216296 FBgn0198287 FBgn0191131 FBgn0165605 JGI_V11_316993 FBgn0075408 FBgn0159791 FBgn0132984 FBgn0130221 FBgn0103490 FBgn0093092 CPIJ007708 BGIBMGA004697 ACYPI010098 GB11919 AGAP004039 AAEL004393 PHUM605280 GLEAN_14012
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}cnod03468 - P{XP}cnod03792 - PBac{PB}cnoc00629 - PBac{PB}cnoc01949 - PBac{PB}cnoc04321 - PBac{RB}cnoe01534 - PBac{RB}cnoe02872 - PBac{WH}cnof00529 - PBac{WH}cnof01707 - PBac{WH}cnof01937 - PBac{WH}cnof03124
VDRC	v102686 P{KK112164}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR01D10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 65 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP13276 LD24616
Other clones	FI05483
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06670 GM22458 LD04126 LD04638 LD11574 LD13894 LD17667 LD17965 LD24906 LD28576 LD31174 LD32725 LD34053 LD36715 LD38878 LD39564 LD46662
Other clones	1851 61262 62674 78552 79720 99417 104066 104260 118664 149129 164080 214415.60 273989 277095 CK01.60A.C7 CK01.61B.A8 CK01.119D.F2 CK01.133B.D6 CK01108 Dmel_neb_011897_0613_3021 Dmel_neb_015005_0588_0456 EK031103 EK047407 EK063312 EK063936 EK091353 EK101947 EK123027 EK185928 EK207837 EK222225 EK227238 EK238060 EK245322 EK254545 EK270036 EK304224 EP15318 EP19258 ESG0114d.B21_G12 FGH106C12 FGM224F03 GH02910 GM02977 IP13476
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259212 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40620 318789
Antibody Information
	polyclonal (Miyamoto et al., 1995, Matsuo et al., 1999) polyclonal (species: Rat; amino acids 729-1171 were used to generate antibody) (Kutchma et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cno CG2534 (Guan, 1999.11)
Source for database merge of	Source for merge of: cno anon-WO0172774.47 (FlyBase, 1996-) Source for merge of: cno CG31537 (FlyBase Genome Annotators, 2008) Source for merge of: lip cno (Mann, 1995.4.4)
Additional comments	snRNA:U4atac:82E is encoded in an intron of cno. (Graveley et al., 2011) Annotations CG2534 and CG31537 merged as CG42312 in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008) "S(CycEJP)68S10" is unlikely to correspond to "cno"; mutations in the two loci complement each other. (Brumby et al., 2004) Source for merge of cno anon-WO0172774.47 was sequence comparison (date:051113). (FlyBase, 1996-) Eleven further alleles (all EMS) discarded by Tubingen.
Other Comments
	cno regulates linkage between adherens junctions and the actin cytoskeleton during morphogenesis. (Sawyer et al., 2009) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) R and cno proteins act in the same molecular pathway during dorsal closure and the function of both proteins in dorsal closure depends on their ability to interact with each other. R acts upstream of cno in dorsal closure, but unlike cno, is not involved in the stimulation of JNK pathway activity. (Boettner et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG31537) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Both loss-of-function mutations of cno and overexpression of cno result in malformation of the rhabdomeres in the ommatidia. (Matsuo et al., 1999) Mutants are isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis: mutants exhibit pattern defects (dorsal open). (Moore et al., 1998) cno protein binds directly to pyd protein. (Takahashi et al., 1998) cno is involved in the JNK pathway for dorsal closure in embryos, as a modulator acting upstream of or in parallel with Rac1. (Takahashi et al., 1998) The mechanism by which cno product controls cone cell formation in the developing compound eye is studied. (Matsuo et al., 1997) lips is likely to be cno based on sequence identity and sequence of a nonsense cno mutation. (Feinstein et al., 1995) Isolated during a subtractive hybridisation protocol to identify Ubx-activated target genes. Ubx inducible during embryogenesis. (Feinstein et al., 1995) Genetic interactions suggest that cno participates with members of the N pathway in regulating adhesive cell-cell interactions for the determination of cell fate. (Miyamoto et al., 1995) cno mutants display failure of dorsal closure. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079508 NM_169025 NM_169026 RefSeq (Proteins) • NP_524232 NP_730891 NP_730892 DDBJ / EMBL / GenBank • AA820744 AAF52067 AAL13776 AAN13260 AAN13261 AW942708 AX260085 AY058547 BAA08478 CZ466610 CZ467575 CZ469173 CZ473386 CZ473560 CZ473561 CZ479347 CZ479348 CZ480644 CZ480645 CZ482992 CZ484174 CZ484438 CZ485676 CZ489704 CZ489705 D49534 Entrez Gene - A searchable database of RefSeq genes. • 40620 UniProtKB/TrEMBL • Q8IPP3 Q8IPP4 Q9VN82 Q95TT5 Q24279
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dil domain (IPR018444) Ras-association (IPR000159) Forkhead-associated (FHA) domain (IPR000253) PDZ/DHR/GLGF (IPR001478) Dilute (IPR002710) SMAD/FHA domain (IPR008984)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65834 DroID - A comprehensive database of gene and protein interactions. • FBgn0259212 DRSC - Results from RNAi screens. • FBgn0259212 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259212 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31537-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259212 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40620 318789 InParanoid A subset of ortholog calls from InParanoid. • AAEL004393-PA Aedes aegypti (mosquito) AGAP004039-PA Anopheles gambiae (mosquito) XP_393645.3 Apis mellifera (honey bee) XP_001944877.1 Acyrthosiphon pisum (pea aphid) 208117 Branchiostoma floridae (lancelet) XP_001893791.1 Brugia malayi (roundworm nematode) BGIBMGA004697-PA Bombyx mori (silk worm) ENSBTAP00000007309 Bos taurus (bovine) CN00780 Caenorhabditis brenneri (small nematode) CBP34462 Caenorhabditis briggsae (nematode) CE26729 Caenorhabditis elegans (worm) ENSCAFP00000001228 Canis familiaris (dog) JA12672 Caenorhabditis japonica (nematode) CPIJ007708 Culex pipens (mosquito) ENSCPOP00000007433 Cavia porcellus (guinea pig) RP27709 Caenorhabditis remanei (nematode) ENSCSAVP00000017818 Ciona savignyi (sedentary tunicate) 316993 Daphnia pulex (daphnia) ENSDARP00000039753 Danio rerio (zebra fish) ENSECAP00000012677 Equus caballus (horse) ENSGALP00000018461 Gallus gallus (chicken) 184008 Hypsipyla robusta (cedar shoot borer) ENSP00000345834 Homo sapiens (human) ISCW019802-PA Ixodes scapularis (deer tick) 210615 Lottia gigantea (owl limpet) ENSMODP00000007516 Monodelphis domestica (gray opossum) ENSMMUP00000027697 Macaca mulatta (rhesus monkey) 174672 Nematostella vectensis (starlet anemone) XP_001605722.1 Nasonia vitripennis (wasp) ENSOANP00000009340 Ornithorynchus anatinus (platypus) PHUM002453-PA Pediculus humanus (human body louse) ENSPPYP00000019236 Pongo pygmaeus (orangutan) ENSPTRP00000049438 Pan troglodytes (chimpanzee) ENSRNOP00000048254 Rattus norvegicus (norway rat) Smp_164340 Schistosoma mansoni (trematode parasite) XP_794644.2 Strongylocentrotus purpuratus (purple sea urchin) 170 Trichoplax adhaerens (metazoa) XP_971214.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022337 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014198 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/canoe1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40620 modMine - Data generated by the modENCODE project. • FBgn0259212 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11000 NV11659 LH16941 ISCW019802 FBgn0242386 FBgn0216296 FBgn0198287 FBgn0191131 FBgn0165605 JGI_V11_316993 FBgn0075408 FBgn0159791 FBgn0132984 FBgn0130221 FBgn0103490 FBgn0093092 CPIJ007708 BGIBMGA004697 ACYPI010098 GB11919 AGAP004039 AAEL004393 PHUM605280 GLEAN_14012
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	AF-6 (Wei et al., 2005) anon-WO0172774.47   Canoe (Carmena and Baylies, 2001) CG2534   CG31537 (Keleman et al., 2009.8.5) CG42312 (FlyBase Genome Annotators, 2008, Ni et al., 2010.12.1) Cno (Carmena and Baylies, 2002, Noselli and Agnes, 1999, Sawyer et al., 2006, Wei et al., 2005, Harris et al., 2008, Formstecher et al., 2005, Mirkovic et al., 2011) cno (Speicher et al., 2007, Menzel et al., 2007, Bakal et al., 2007, Lecuyer et al., 2007, Boettner and Van Aelst, 2007, Speicher et al., 2008, Sawyer et al., 2009, Fetting et al., 2009, Buffin and Gho, 2010, Graveley et al., 2011, Sela et al., 2010) dlhA   lip (Feinstein et al., 1995, ) mis
Name Synonym	Afadin (Sawyer et al., 2006, Margolis and Borg, 2005) afadin (Wei et al., 2005) canoe (Kuriyama et al., 1996, Menzel et al., 2007, O'Keefe et al., 2009, Fetting et al., 2009, Formstecher et al., 2005, Buffin and Gho, 2010, Bothma et al., 2011) Canoe (Tepass and Harris, 2007, Cho et al., 2005, Wei et al., 2005, Harris et al., 2008, Boettner and Van Aelst, 2007, Speicher et al., 2008) CG31537   CG42312 (FlyBase Genome Annotators, 2008) dorsal holes A   lips (Graba et al., 1997, Botas and Auwers, 1996, Feinstein et al., 1995, ) misty
Secondary FlyBase IDs
	FBgn0000340 FBgn0000465 FBgn0005637 FBgn0046384 FBgn0051537
References ( 128 )
Generate a list of	All references relating to this gene ( 128 )
List References by type	Research paper  ( 45 ) Supplementary material  ( 7 ) Review  ( 33 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 14 ) FlyBase analysis  ( 5 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 ) Patent  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 ) Book  ( 1 ) Poem  ( 1 )
Recent research papers ( 6 )
	Bothma et al., 2011, Curr. Biol. 21(18): 1571--1577 The Snail Repressor Inhibits Release, Not Elongation, of Paused Pol II in the Drosophila Embryo. [FBrf0216305] Jankovics et al., 2011, PLoS ONE 6(7): e22229 A functional genomic screen combined with time-lapse microscopy uncovers a novel set of genes involved in dorsal closure of Drosophila embryos. [FBrf0214545] Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672 Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849] Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation. [FBrf0216492] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Sela et al., 2010, Genome Biol. 11(6): R59 The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. [FBrf0214867] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...