FlyBase Gene Report: Dmel\Ir93a

General Information

Symbol

Dmel\Ir93a

Species

D. melanogaster

Name

Ionotropic receptor 93a

Annotation Symbol

CG42315

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259215

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27656904, PubMed:27161501). Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27656904, PubMed:27161501). (UniProt, Q9VDH6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

93A2-93A2

Sequence location

3R:20,851,709..20,859,945 [-]

Recombination map

3-69

RefSeq locus

NT_033777 REGION:20851709..20859945

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ligand-gated ion channel activity

inferred from sequence model

(Benton et al., 2009)

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception

inferred from expression pattern

(Benton et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Benton et al., 2009)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS

Protein Family (UniProt)

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q9VDH6)

Protein Signatures (InterPro)

Ionotropic glutamate receptor

Summaries

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS -: Ionotropic Receptors (IR) co-receptors are part of the IR family. They are broadly, but selectively, expressed in antennal sensory neurons in Drosophila. Some antenneal IRs only form functional odor-responsive ion channels as a heteromeric complex with an IR co-receptor. (Adapted from FBrf0222310).

Protein Function (UniProtKB)

(UniProt, Q9VDH6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir93a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.48

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq data). May be specific to sequenced strain; not included in gene model.

Mutation in sequenced strain: insertion of transposon.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir93a-RD

FBtr0336970

NM_142667

2742

868

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ir93a-PD

FBpp0307913

99.6

868

6.22

NP_650924

AAF55817

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Ionotropic glutamate receptor

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VDH6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir93a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir93a_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic head sensory system

(Fisher et al., 2012)

adult stage

sacculus | restricted

Comment: neurons surrounding the first and second chambers of the sacculus

(Benton et al., 2009)

neuron of coeloconic sensillum of antennal segment 3

(Benton et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antenna

(Croset et al., 2010)

Additional Descriptive Data

Ir93a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 adjacent to the chambers I and II of the sacculus.

(Benton et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antennal lobe glomerulus VP5

(Knecht et al., 2017)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

dorsal organ cool cell

• dendrite terminus

(Knecht et al., 2016)

adult stage

adult hygrosensory neuron Ir40a

(Knecht et al., 2016)

aristal sensory neuron VP3

(Budelli et al., 2019)

aristal sensory neuron VP2

(Budelli et al., 2019)

Additional Descriptive Data

Ir93a protein is detected in cold cell sensory endings. It is also detected in hot cells.

(Budelli et al., 2019)

Ir93a is expressed in dorsal organ cool cells marked by expression driven by Scer\GAL4^Ir21a.PK and localizes prominently to the dendritic bulb at the tip of the sensory processes. It is also expressed in Ir25a and Ir40a positive adult olfactory receptor neuron Ir40a.

(Knecht et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir93a-GAL4.237}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gustatory receptor neuron of the dorsal organ

(Sánchez-Alcañiz et al., 2018)

adult stage

adult antennal olfactory receptor neuron | subset

(Sánchez-Alcañiz et al., 2018)

Reporter: P{Ir93a-lexA.U}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

chamber I of sacculus | restricted

(Frank et al., 2017)

chamber II of sacculus | restricted

(Frank et al., 2017)

aristal sensory neuron VP2

(Frank et al., 2017)

aristal sensory neuron VP3

(Frank et al., 2017)

Reporter: P{VT044927-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

superior lateral protocerebrum

(Jefferis, 2016.3.4)

antennal mechanosensory and motor center

(Jefferis, 2016.3.4)

superior medial protocerebrum

(Jefferis, 2016.3.4)

adult antennal lobe

(Jefferis, 2016.3.4)

adult lateral accessory lobe

(Jefferis, 2016.3.4)

adult lateral horn

(Jefferis, 2016.3.4)

adult hygrosensory neuron Ir68a

(Sun et al., 2018)

adult hygrosensory neuron Ir40a VP4

(Sun et al., 2018)

chamber II of sacculus

(Sun et al., 2018)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir93a in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir93a

View exonic expression by tissue for Dmel\Ir93a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259215

DRscDB

42471/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0259215

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17275-RA;CG17274-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17274

Flygut - An atlas of the Drosophila adult midgut

FBgn0259215

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir93a

Transgenic constructs containing regulatory region of Ir93a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Ir93a^KK103661

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRIA1

3 of 15

Yes

Hsap\GRIA2

3 of 15

Yes

Hsap\GRIA3

3 of 15

Yes

Hsap\GRIA4

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gria1

3 of 15

Yes

Mmus\Gria2

3 of 15

Yes

Mmus\Gria3

3 of 15

Yes

Mmus\Gria4

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Rattus norvegicus (Norway rat) (16)

Rnor\Gria3

3 of 13

Yes

Rnor\Gria4

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Grin3b

2 of 13

Yes

Rnor\Grik1

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\gria1

3 of 12

Yes

Xtro\gria3

3 of 12

Yes

Xtro\gria4

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\grik5-like.1

1 of 12

Danio rerio (Zebrafish) (32)

Drer\gria1a

3 of 15

Yes

Drer\gria1b

3 of 15

Yes

Drer\gria2a

3 of 15

Yes

Drer\gria2b

3 of 15

Yes

Drer\gria3a

3 of 15

Yes

Drer\gria3b

3 of 15

Yes

Drer\gria4b

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\grin3ba

2 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

Drer\LOC100537813

1 of 15

Drer\LOC110438919

1 of 15

Drer\si:ch211-251b21.1

1 of 15

Drer\si:dkey-183j2.10

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-1

2 of 15

Yes

Cele\glr-2

2 of 15

Yes

Cele\glr-8

2 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR2

2 of 9

Yes

Atha\GLR3.3

2 of 9

Yes

Atha\GLR3.4

2 of 9

Yes

Atha\GLR3.5

2 of 9

Yes

Atha\GLR3.6

2 of 9

Yes

Atha\GLR5

2 of 9

Yes

Atha\GLUR2

2 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902FH )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA30143

Drosophila persimilis

Dper\GL23256

Drosophila willistoni

Dwil\GK22692

Drosophila virilis

Dvir\GJ24269

Drosophila mojavensis

Dmoj\GI22152

Drosophila grimshawi

Dgri\GH17280

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018162

Mayetiola destructor

Hessian fly

Mdes\Mdes016830

Mayetiola destructor

Hessian fly

Mdes\Mdes015305

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005012

Anopheles darlingi

American malaria mosquito

Adar\ADAC002667

Anopheles gambiae

Malaria mosquito

Agam\IR93a

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009222

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W014U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010960

Danaus plexippus

Monarch butterfly

Dple\DPOGS209236-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002270

Apis florea

Little honeybee

Aflo\2675032932

Apis mellifera

Western honey bee

Amel\GB50521

Apis mellifera

Western honey bee

Amel\GB42136

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19508

Bombus terrestris

Buff-tailed bumblebee

Bter\15212805

Linepithema humile

Argentine ant

Lhum\LH25937

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002054

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001464

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04142

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04143

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04145

Tribolium castaneum

Red flour beetle

Tcas\TC000374

Pediculus humanus

Human body louse

Phum\PHUM513120

Rhodnius prolixus

Kissing bug

Rpro\RPRC008486

Cimex lectularius

Bed bug

Clec\CLEC002676

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI43510

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18953

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01OK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014443

Ixodes scapularis

Black-legged tick

Isca\ISCW007957

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g05540

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_309629

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_258425

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_329001

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (43)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

model of syndromic X-linked intellectual disability 94

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

3 of 15

138248

GRIA2; glutamate ionotropic receptor AMPA type subunit 2

3 of 15

138247

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND BEHAVIORAL ABNORMALITIES; NEDLIB

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

3 of 15

305915

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, WU TYPE; MRXSW

syndromic X-linked intellectual disability 94

GRIA4; glutamate ionotropic receptor AMPA type subunit 4

3 of 15

138246

NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT SEIZURES AND GAIT ABNORMALITIES; NEDSGA

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259215

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-69

Cytogenetic map

93A2-93A2

Sequence location

3R:20,851,709..20,859,945 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93A2-93A2

Limits computationally determined from genome sequence between P{EP}Synd^EP409 and P{lacW}l(3)j5C7^j5C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-69

(FlyBase, 2016)

3-73.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

24810

w¹¹¹⁸; Mi{ET1}Ir93a^MB04433

63700

y¹ v¹; P{TRiP.HMJ30268}attP40

42090

y¹ w^*; Mi{MIC}Ir93a^MI05555

84075

y¹ v¹; P{TKO.GS05544}attP2/TM3 Sb¹

58887

w^*; TI{TI}mir-1011^KO Ir93a^mir-1011-KO/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb¹ Ser¹

VDRC

v100837

P{KK103661}VIE-260B

v102983

P{KK112981}VIE-260B

v342345

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02146}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH01149

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259215

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42471

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Knecht et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ir93a CG42315

(Benton et al., 2009)

Source for database merge of

Source for merge of: CG17274 CG17275

(FlyBase Genome Annotators, 2008)

Additional comments

Annotations CG17274 and CG17275 merged as CG42315 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

One of the introns of CG17274 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG17274 intron is mir-1011.

(Ruby et al., 2007)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 30 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42471

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VDH6

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259215

DRscDB

42471/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0259215

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir93a_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17274

Flygut - An atlas of the Drosophila adult midgut

FBgn0259215

FlyMine - An integrated database for Drosophila genomics

FBgn0259215

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42471

InterPro - A database of protein families, domains and functional sites

Ionotropic glutamate receptor

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42315

MARRVEL_MODEL

42471

modMine - A data warehouse for the modENCODE project

FBgn0259215

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259215

DRSC - Results frm RNAi screens

FBgn0259215

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17275-RA;CG17274-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259215

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

93a

(Ni, 2020)

CG17274

(Keleman et al., 2009.8.5, Lee et al., 2009, Ruby et al., 2007, Lipatov et al., 2005)

CG17275

(Keleman et al., 2009.8.5, Lee et al., 2009)

CG42315

(Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Perkins et al., 2009, FlyBase Genome Annotators, 2008)

CT35907

(Littleton and Ganetzky, 2000)

DmelIR93a

(Croset et al., 2010)

IR93a

(George and Stanewsky, 2021, Xiao and Xu, 2021, Ni, 2020, Lei et al., 2019, Gomez-Diaz et al., 2018, Rimal and Lee, 2018, Knecht et al., 2017, Transgenic RNAi Project members, 2017-, Menuz et al., 2014, Silbering et al., 2011, Croset et al., 2010, Benton et al., 2009)

Ir93a

(McLaughlin et al., 2021, Li et al., 2020, Budelli et al., 2019, Mossman et al., 2019, Frank et al., 2017, Ganguly et al., 2017, Crocker et al., 2016, Enjin et al., 2016, Knecht et al., 2016, Chen et al., 2014, Catalán et al., 2012, Tsubouchi et al., 2012)

ir93a

(Riveron et al., 2013)

Name Synonyms

CG17274

CG17275

CG42315

(FlyBase Genome Annotators, 2008)

Ionotropic receptor 93a

(Tsubouchi et al., 2012)

ionotropic receptor 93a

(Benton et al., 2009)

Secondary FlyBase IDs

FBgn0038835
FBgn0038836

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (56)

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