FB2021_05, released October 15, 2021

Gene: Dmel\Ir93a

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General Information
Symbol
Dmel\Ir93a
Species
D. melanogaster
Name
Ionotropic receptor 93a
Annotation Symbol
CG42315
Feature Type
protein_coding_gene
FlyBase ID
FBgn0259215
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27656904, PubMed:27161501). Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27656904, PubMed:27161501). (UniProt, Q9VDH6)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
93A2-93A2
Sequence location
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20851709..20859945
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ligand-gated ion channel activity
inferred from sequence model
(Benton et al., 2009)
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
enables signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in detection of chemical stimulus involved in sensory perception
inferred from expression pattern
(Benton et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence model
(Benton et al., 2009)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q9VDH6)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ANTENNAL IONOTROPIC CO-RECEPTORS -
Ionotropic Receptors (IR) co-receptors are part of the IR family. They are broadly, but selectively, expressed in antennal sensory neurons in Drosophila. Some antenneal IRs only form functional odor-responsive ion channels as a heteromeric complex with an IR co-receptor. (Adapted from FBrf0222310).
Protein Function (UniProtKB)
Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27656904, PubMed:27161501). Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27656904, PubMed:27161501).
(UniProt, Q9VDH6)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ir93a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.48

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq data). May be specific to sequenced strain; not included in gene model.

Mutation in sequenced strain: insertion of transposon.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ir93a-RD
FBtr0336970
NM_142667
2742
868
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ir93a-PD
FBpp0307913
99.6
868
6.22
NP_650924
AAF55817
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir93a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
antennal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic head sensory system
(Fisher et al., 2012)
adult stage
sacculus | restricted

Comment: neurons surrounding the first and second chambers of the sacculus

(Benton et al., 2009)
neuron of coeloconic sensillum of antennal segment 3
(Benton et al., 2009)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna
(Croset et al., 2010)
Additional Descriptive Data

Ir93a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 adjacent to the chambers I and II of the sacculus.

(Benton et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antennal lobe glomerulus VP5
(Knecht et al., 2017)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
dorsal organ cool cell
(Knecht et al., 2016)
adult stage
adult hygrosensory neuron Ir40a
(Knecht et al., 2016)
aristal sensory neuron VP3
(Budelli et al., 2019)
aristal sensory neuron VP2
(Budelli et al., 2019)
Additional Descriptive Data

Ir93a protein is detected in cold cell sensory endings. It is also detected in hot cells.

(Budelli et al., 2019)

Ir93a is expressed in dorsal organ cool cells marked by expression driven by Scer\GAL4Ir21a.PK and localizes prominently to the dendritic bulb at the tip of the sensory processes. It is also expressed in Ir25a and Ir40a positive adult olfactory receptor neuron Ir40a.

(Knecht et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir93a in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ir93a
Transgenic constructs containing regulatory region of Ir93a
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GRIA1
3 of 15
Yes
No
2  
Hsap\GRIA2
3 of 15
Yes
No
2  
Hsap\GRIA3
3 of 15
Yes
No
Hsap\GRIA4
3 of 15
Yes
No
Hsap\GRID1
2 of 15
No
No
Hsap\GRID2
2 of 15
No
No
Hsap\GRIK1
2 of 15
No
No
Hsap\GRIK2
2 of 15
No
No
Hsap\GRIK3
2 of 15
No
No
Hsap\GRIK4
2 of 15
No
No
Hsap\GRIK5
2 of 15
No
No
1  
Hsap\GRIN2A
2 of 15
No
No
Hsap\GRIN2B
2 of 15
No
No
Hsap\GRIN2C
2 of 15
No
No
Hsap\GRIN2D
2 of 15
No
No
Hsap\GRIN3A
2 of 15
No
No
Hsap\GRIN3B
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gria1
3 of 15
Yes
No
2  
Mmus\Gria2
3 of 15
Yes
No
Mmus\Gria3
3 of 15
Yes
No
Mmus\Gria4
3 of 15
Yes
No
Mmus\Grid1
2 of 15
No
No
Mmus\Grid2
2 of 15
No
No
Mmus\Grik1
2 of 15
No
No
Mmus\Grik2
2 of 15
No
No
Mmus\Grik3
2 of 15
No
No
Mmus\Grik4
2 of 15
No
No
Mmus\Grik5
2 of 15
No
No
Mmus\Grin2a
2 of 15
No
No
Mmus\Grin2b
2 of 15
No
No
Mmus\Grin2c
2 of 15
No
No
Mmus\Grin2d
2 of 15
No
No
Mmus\Grin3a
2 of 15
No
No
Mmus\Grin3b
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (16)
Rnor\Gria3
3 of 13
Yes
No
Rnor\Gria4
3 of 13
Yes
No
Rnor\Gria1
2 of 13
No
No
Rnor\Gria2
2 of 13
No
No
Rnor\Grid2
2 of 13
No
No
Rnor\Grik2
2 of 13
No
No
Rnor\Grik3
2 of 13
No
No
Rnor\Grik4
2 of 13
No
No
Rnor\Grik5
2 of 13
No
No
Rnor\Grin2a
2 of 13
No
No
Rnor\Grin2b
2 of 13
No
No
Rnor\Grin2c
2 of 13
No
No
Rnor\Grin2d
2 of 13
No
No
Rnor\Grin3a
2 of 13
No
Yes
Rnor\Grin3b
2 of 13
No
Yes
Rnor\Grik1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\gria1
3 of 12
Yes
No
Xtro\gria3
3 of 12
Yes
No
Xtro\gria4
3 of 12
Yes
No
Xtro\grid1
2 of 12
No
No
Xtro\grid2
2 of 12
No
No
Xtro\grik1
2 of 12
No
No
Xtro\grik4
2 of 12
No
No
Xtro\grin2b
2 of 12
No
No
Xtro\grin2c
2 of 12
No
No
Xtro\grin2d
2 of 12
No
No
Xtro\grin3b
2 of 12
No
Yes
Xtro\grik5-like.1
1 of 12
No
No
Danio rerio (Zebrafish) (32)
Drer\gria1a
3 of 15
Yes
No
Drer\gria1b
3 of 15
Yes
No
Drer\gria2a
3 of 15
Yes
No
Drer\gria2b
3 of 15
Yes
No
Drer\gria3a
3 of 15
Yes
No
Drer\gria3b
3 of 15
Yes
No
Drer\gria4b
3 of 15
Yes
No
Drer\gria4a
2 of 15
No
No
Drer\grid1a
2 of 15
No
No
Drer\grid1b
2 of 15
No
No
Drer\grid2
2 of 15
No
No
Drer\grik1a
2 of 15
No
No
Drer\grik1b
2 of 15
No
No
Drer\grik2
2 of 15
No
No
Drer\grik4
2 of 15
No
No
Drer\grin2aa
2 of 15
No
No
Drer\grin2ab
2 of 15
No
No
Drer\grin2bb
2 of 15
No
No
Drer\grin2ca
2 of 15
No
No
Drer\grin2cb
2 of 15
No
No
Drer\grin2da
2 of 15
No
No
Drer\grin3a
2 of 15
No
Yes
Drer\grin3ba
2 of 15
No
Yes
Drer\LOC100149482
2 of 15
No
No
Drer\LOC100331381
2 of 15
No
No
Drer\LOC100334689
2 of 15
No
No
Drer\grik5
1 of 15
No
No
Drer\grin3bb
1 of 15
No
Yes
Drer\LOC100537813
1 of 15
No
No
Drer\LOC110438919
1 of 15
No
No
Drer\si:ch211-251b21.1
1 of 15
No
No
Drer\si:dkey-183j2.10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\glr-1
2 of 15
Yes
No
Cele\glr-2
2 of 15
Yes
No
Cele\glr-8
2 of 15
Yes
No
Cele\C08B6.5
1 of 15
No
No
Cele\F59E12.8
1 of 15
No
Yes
Cele\glr-3
1 of 15
No
No
Cele\glr-4
1 of 15
No
No
Cele\glr-5
1 of 15
No
No
Cele\glr-6
1 of 15
No
No
Cele\glr-7
1 of 15
No
No
Cele\nmr-2
1 of 15
No
No
Cele\spp-22
1 of 15
No
Yes
Cele\T25E4.2
1 of 15
No
Yes
Cele\W02A2.5
1 of 15
No
No
Cele\ZK867.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (20)
Atha\GLR2
2 of 9
Yes
No
Atha\GLR3.3
2 of 9
Yes
No
Atha\GLR3.4
2 of 9
Yes
No
Atha\GLR3.5
2 of 9
Yes
No
Atha\GLR3.6
2 of 9
Yes
No
Atha\GLR5
2 of 9
Yes
No
Atha\GLUR2
2 of 9
Yes
No
Atha\ATGLR1.2
1 of 9
No
No
Atha\GLR1.1
1 of 9
No
No
Atha\GLR1.3
1 of 9
No
No
Atha\GLR1.4
1 of 9
No
No
Atha\GLR2.1
1 of 9
No
No
Atha\GLR2.2
1 of 9
No
No
Atha\GLR2.3
1 of 9
No
No
Atha\GLR2.4
1 of 9
No
No
Atha\GLR2.5
1 of 9
No
No
Atha\GLR2.6
1 of 9
No
No
Atha\GLR2.7
1 of 9
No
No
Atha\GLR2.8
1 of 9
No
No
Atha\GLR2.9
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902FH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012950
Drosophila simulans
Dsim\GD20027
Drosophila sechellia
Dsec\GM23153
Drosophila erecta
Dere\GG15081
Drosophila yakuba
Dyak\GE25033
Drosophila yakuba
Dyak\GE28685
Drosophila ananassae
Dana\GF17010
Drosophila pseudoobscura pseudoobscura
Dpse\GA30143
Drosophila persimilis
Dper\GL23256
Drosophila willistoni
Dwil\GK22692
Drosophila virilis
Dvir\GJ24269
Drosophila mojavensis
Dmoj\GI22152
Drosophila grimshawi
Dgri\GH17280
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018162
Mayetiola destructor
Hessian fly
Mdes\Mdes016830
Mayetiola destructor
Hessian fly
Mdes\Mdes015305
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005012
Anopheles darlingi
American malaria mosquito
Adar\ADAC002667
Anopheles gambiae
Malaria mosquito
Agam\IR93a
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009222
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W014U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010960
Danaus plexippus
Monarch butterfly
Dple\DPOGS209236-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002270
Apis florea
Little honeybee
Aflo\2675032932
Apis mellifera
Western honey bee
Amel\GB50521
Apis mellifera
Western honey bee
Amel\GB42136
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19508
Bombus terrestris
Buff-tailed bumblebee
Bter\15212805
Linepithema humile
Argentine ant
Lhum\LH25937
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002054
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001464
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04142
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04143
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04145
Tribolium castaneum
Red flour beetle
Tcas\TC000374
Pediculus humanus
Human body louse
Phum\PHUM513120
Rhodnius prolixus
Kissing bug
Rpro\RPRC008486
Cimex lectularius
Bed bug
Clec\CLEC002676
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI43510
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18953
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01OK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014443
Ixodes scapularis
Black-legged tick
Isca\ISCW007957
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05540
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309629
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_258425
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_329001
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (43)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG11155
3 of 10
clumsy
3 of 10
Ekar
3 of 10
GluRIA
3 of 10
GluRIB
3 of 10
GluRIIA
3 of 10
GluRIIB
3 of 10
GluRIIC
3 of 10
GluRIID
3 of 10
GluRIIE
3 of 10
Grik
3 of 10
Ir25a
3 of 10
Ir64a
3 of 10
Ir75a
3 of 10
Ir75c
3 of 10
Ir75d
3 of 10
Ir76b
3 of 10
Ir84a
3 of 10
Nmdar2
3 of 10
Ir7b
2 of 10
Ir7c
2 of 10
Ir7d
2 of 10
Ir7e
2 of 10
Ir7f
2 of 10
Ir7g
2 of 10
Ir8a
2 of 10
Ir21a
2 of 10
Ir31a
2 of 10
Ir60a
2 of 10
Ir68a
2 of 10
Ir75b
2 of 10
Ir85a
2 of 10
KaiR1D
2 of 10
Nmdar1
2 of 10
Ir7a
1 of 10
Ir11a
1 of 10
Ir40a
1 of 10
Ir41a
1 of 10
Ir68b
1 of 10
Ir76a
1 of 10
Ir87a
1 of 10
Ir92a
1 of 10
Ir94d
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GRIA1; glutamate ionotropic receptor AMPA type subunit 1
    3 of 15
    138248
         
        GRIA2; glutamate ionotropic receptor AMPA type subunit 2
        3 of 15
        138247
           
          GRIA3; glutamate ionotropic receptor AMPA type subunit 3
          3 of 15
          305915
          GRIA4; glutamate ionotropic receptor AMPA type subunit 4
          3 of 15
          138246
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-69
            Cytogenetic map
            93A2-93A2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            93A2-93A2
            Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-69

            (FlyBase, 2016)

            3-73.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (11)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Knecht et al., 2016)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Ir93a CG42315

              (Benton et al., 2009)
              Source for database merge of

              Source for merge of: CG17274 CG17275

              (FlyBase Genome Annotators, 2008)
              Additional comments

              Annotations CG17274 and CG17275 merged as CG42315 in release 5.9 of the genome annotation.

              (FlyBase Genome Annotators, 2008)

              One of the introns of CG17274 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG17274 intron is mir-1011.

              (Ruby et al., 2007)
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 32 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Synonyms and Secondary IDs (11)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (58)