FlyBase Gene Report: Dmel\ATP8A

General Information

Symbol

Dmel\ATP8A

Species

D. melanogaster

Name

ATPase 8A

Annotation Symbol

CG42321

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259221

Gene Model Status

Current

Stock Availability

18 publicly available

Enzyme Name (EC)

P-type phospholipid transporter (7.6.2.1)

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

50A5-50A8

Sequence location

2R:13,414,978..13,439,051 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13414978..13439051

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

ATPase-coupled intramembrane lipid transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

magnesium ion binding

inferred from electronic annotation with InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

phospholipid translocation

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN001184504

(assigned by GO_Central )

(Gaudet et al., 2011)

integral component of membrane

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence model

(Tanaka et al., 2011)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN001943259

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2) (7.6.2.1)

Summaries

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES -: The phospholipid transporting type IV P-ATPases are flippases that translocate phospholipids against concentration gradient from one side of a membrane to the other. This lipid shuttling forms new membrane structures, in particular vesicles. (Adapted from PMID:18439418 and PMID:26240149).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ATP8A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ATP8A-RE

FBtr0299754

NM_137029

4365

1150

ATP8A-RG

FBtr0299755

NM_001144177

5273

1324

ATP8A-RH

FBtr0299757

NM_001144179

5566

1350

ATP8A-RI

FBtr0299756

NM_001144178

4974

1216

ATP8A-RJ

FBtr0299758

NM_001144180

4655

1095

ATP8A-RK

FBtr0299759

NM_165984

4658

1176

ATP8A-RL

FBtr0299760

NM_001144181

4552

1091

ATP8A-RM

FBtr0299761

NM_001144182

4261

1150

ATP8A-RN

FBtr0299762

NM_170625

4553

1275

ATP8A-RO

FBtr0299763

NM_001144183

4787

1275

ATP8A-RP

FBtr0299764

NM_170624

5080

1301

ATP8A-RQ

FBtr0299765

NM_001144184

5460

1265

ATP8A-RR

FBtr0303100

NM_001201990

4930

1082

ATP8A-RS

FBtr0306698

NM_001259361

3980

1127

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

ATP8A-PE

FBpp0289032

130.9

1150

6.09

NP_610873

AAM68573

ATP8A-PG

FBpp0289033

149.6

1324

6.76

NP_001137649

ACL83103

ATP8A-PH

FBpp0289035

152.4

1350

7.04

NP_001137651

ACL83105

ATP8A-PI

FBpp0289034

137.5

1216

7.26

NP_001137650

ACL83104

ATP8A-PJ

FBpp0289036

124.7

1095

6.17

NP_001137652

ACL83106

ATP8A-PK

FBpp0289037

133.7

1176

6.51

NP_725290

AAF58378

ATP8A-PL

FBpp0289038

124.3

1091

6.11

NP_001137653

ACL83107

ATP8A-PM

FBpp0289039

130.9

1150

6.09

NP_001137654

ACL83108

ATP8A-PN

FBpp0289040

144.1

1275

7.18

NP_725292

AAM68575

ATP8A-PO

FBpp0289041

144.1

1275

7.18

NP_001137655

ACL83109

ATP8A-PP

FBpp0289042

146.9

1301

7.53

NP_725291

AAM68574

ATP8A-PQ

FBpp0289043

143.0

1265

6.80

NP_001137656

ACL83110

ATP8A-PR

FBpp0292219

123.3

1082

6.26

NP_001188919

ADV37166

ATP8A-PS

FBpp0297637

128.2

1127

5.82

NP_001246290

AFH08044

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1150 aa isoforms: ATP8A-PE, ATP8A-PM

1275 aa isoforms: ATP8A-PN, ATP8A-PO

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATP8A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic large intestine

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

hindgut proper primordium

Comment: reported as hindgut proper anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ATP8A in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ATP8A

View exonic expression by tissue for Dmel\ATP8A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259221

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259221

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17034-RA;CG30061-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17034

Flygut - An atlas of the Drosophila adult midgut

FBgn0259221

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ATP8A

Transgenic constructs containing regulatory region of ATP8A

Deletions and Duplications ( 1 )

Partially disrupted in

Df(2R)cnn^25cn1

(Zhang and Megraw, 2007)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

ATP8A^GD9980

viable

ATP8A^{MI06777-GFSTF.1}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

ATP8A^GD3507

viable, with Scer\GAL4^tin.CΔ4

ATP8A^GD3507

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

ATP8A^GD9980

Phenotype manifest in

Allele

larval multidendritic class IV neuron | larval stage, with Spyo\Cas9^ppk.PS

ATP8A^sgRNA.U6

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ATP8A1

14 of 15

Yes

Hsap\ATP8A2

12 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Atp8a1

14 of 15

Yes

Mmus\Atp8a2

12 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (30)

Rnor\Atp8a2

7 of 13

Yes

Rnor\Atp8a1

5 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

Yes

Rnor\Atp11a

3 of 13

Rnor\Atp11c

3 of 13

Rnor\Atp8b4

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (31)

Xtro\atp8a1

7 of 12

Yes

Xtro\atp8a2

3 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (39)

Drer\atp8a2

10 of 15

Yes

Drer\atp8b5b

5 of 15

Drer\atp8a1

4 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

Yes

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

Drer\si:dkey-211e20.10

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\tat-1

13 of 15

Yes

4 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (12)

Atha\ACA.l

7 of 9

Yes

Atha\ALA3

7 of 9

Yes

Atha\AT1G17500

7 of 9

Yes

Atha\AT1G54280

7 of 9

Yes

Atha\AT1G68710

7 of 9

Yes

Atha\AT3G13900

7 of 9

Yes

Atha\AT3G25610

7 of 9

Yes

Atha\AT3G27870

7 of 9

Yes

Atha\AT1G26130

6 of 9

Yes

Atha\AT1G72700

6 of 9

Yes

Atha\ALA1

2 of 9

Atha\ALA2

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\DRS2

13 of 15

Yes

Scer\DNF1

5 of 15

Scer\DNF2

4 of 15

Scer\DNF3

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\SPBC887.12

10 of 12

Yes

Spom\SPAC4F10.16c

3 of 12

Spom\SPAC24B11.12c

3 of 12

Yes

Spom\SPAC821.13c

2 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901IU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA30467

Drosophila persimilis

Dper\GL10402

Drosophila willistoni

Dwil\GK10743

Drosophila virilis

Dvir\GJ21316

Drosophila mojavensis

Dmoj\GI18942

Drosophila grimshawi

Dgri\GH23120

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500NT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021609

Glossina morsitans

Tsetse fly

Gmor\GMOY005494

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01321

Mayetiola destructor

Hessian fly

Mdes\Mdes001168

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL000767

Anopheles darlingi

American malaria mosquito

Adar\ADAC002109

Anopheles gambiae

Malaria mosquito

Agam\AGAP011483

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006230

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00YU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001074

Danaus plexippus

Monarch butterfly

Dple\DPOGS215959-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016449

Apis florea

Little honeybee

Aflo\2657161572

Apis mellifera

Western honey bee

Amel\GB55658

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19603

Bombus terrestris

Buff-tailed bumblebee

Bter\15215047

Linepithema humile

Argentine ant

Lhum\LH15015

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000eab

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016495

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04536

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07810

Pediculus humanus

Human body louse

Phum\PHUM041040

Rhodnius prolixus

Kissing bug

Rpro\RPRC002676

Cimex lectularius

Bed bug

Clec\CLEC009943

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005726

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI088207

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03844

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00X3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014473

Ixodes scapularis

Black-legged tick

Isca\ISCW009949

Tetranychus urticae

Two-spotted spider mite

Turt\tetur21g01130

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_318356

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0139 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atp8a1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atp8b2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atp8a1_1

Ciona intestinalis

Vase tunicate

Cint\LOC100186827

Ciona intestinalis

Vase tunicate

Cint\LOC100185432

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005896

Ciona intestinalis

Vase tunicate

Cint\LOC100179108

Gallus gallus

Domestic chicken

Ggal\LOC431656

Gallus gallus

Domestic chicken

Ggal\ATP8A2

Gallus gallus

Domestic chicken

Ggal\ATP8B3

Gallus gallus

Domestic chicken

Ggal\ATP8B1

Gallus gallus

Domestic chicken

Ggal\ATP10B

Gallus gallus

Domestic chicken

Ggal\ATP10A

Gallus gallus

Domestic chicken

Ggal\ATP8A1

Gallus gallus

Domestic chicken

Ggal\ATP8B2

Gallus gallus

Domestic chicken

Ggal\ATP10D

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

6 of 10

5 of 10

4 of 10

4 of 10

3 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ATP8A2; ATPase phospholipid transporting 8A2

model of cerebellar ataxia, mental retardation and dysequlibrium syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP8A1; ATPase phospholipid transporting 8A1

14 of 15

609542

ATP8A2; ATPase phospholipid transporting 8A2

12 of 15

605870

CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 4; CAMRQ4

cerebellar ataxia, mental retardation and dysequlibrium syndrome

ATP8B1; ATPase phospholipid transporting 8B1

4 of 15

602397

ATP8B2; ATPase phospholipid transporting 8B2

4 of 15

605867

ATP8B3; ATPase phospholipid transporting 8B3

4 of 15

605866

ATP8B4; ATPase phospholipid transporting 8B4 (putative)

4 of 15

609123

ATP11B; ATPase phospholipid transporting 11B (putative)

4 of 15

605869

ATP11A; ATPase phospholipid transporting 11A

3 of 15

605868

ATP11C; ATPase phospholipid transporting 11C

3 of 15

300516

HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED

X-linked congenital hemolytic anemia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259221

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36488

MIST (protein-protein) - An integrated Molecular Interaction Database

CG42321

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

50A5-50A8

Sequence location

2R:13,414,978..13,439,051 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50A5-50A8

Limits computationally determined from genome sequence between P{EP}Dp^EP358 and P{lacW}drk^k13809&P{EP}mip120^EP606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-72.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Bloomington

22098

w¹¹¹⁸; P{EPg}ATP8A^HP26676

25463

w¹¹¹⁸; Mi{ET1}ATP8A^MB05800

34250

y¹ w^*; Mi{MIC}ATP8A^MI01815

42175

y¹ w^*; Mi{MIC}ATP8A^MI06777

44824

y¹ w^*; Mi{MIC}ATP8A^MI08838

22883

y¹ w^67c23; Mi{ET1}ATP8A^MB00733

13573

y¹ w^67c23; P{SUPor-P}ATP8A^KG03082

14134

y¹ w^67c23; P{SUPor-P}ATP8A^KG05950

VDRC

v107000

P{KK101296}VIE-260B

v33667

w¹¹¹⁸ P{GD9980}v33667

v8136

w¹¹¹⁸; P{GD3507}v8136

v33668

w¹¹¹⁸; P{GD9980}v33668

More stocks available...

Genomic Clones (32)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP15278

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259221

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259221

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36488

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: ATP8A CG42321

(Sapar et al., 2018)

Source for database merge of

Source for merge of: CG17034 CG30061

(FlyBase Genome Annotators, 2008)

Source for merge of: CG17034 anon-WO0153538.54

(FlyBase, 1996-)

Additional comments

Annotations CG17034 and CG30061 merged as CG42321 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Source for merge of CG17034 anon-WO0153538.54 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

New annotation (CG30061) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 104 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36488

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259221

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259221

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17034

Flygut - An atlas of the Drosophila adult midgut

FBgn0259221

FlyMine - An integrated database for Drosophila genomics

FBgn0259221

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36488

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42321

modMine - A data warehouse for the modENCODE project

FBgn0259221

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259221

DRSC - Results frm RNAi screens

FBgn0259221

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259221

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17034-RA;CG30061-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259221

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36488

MIST (protein-protein) - An integrated Molecular Interaction Database

CG42321

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

ATP8A

(FlyBase Genome Annotators, 2019-, Gene Disruption Project members, 2018-, Sapar et al., 2018)

CG17034

(Schertel et al., 2013, Gan et al., 2010, Keleman et al., 2009.8.5, Zhang and Megraw, 2007)

CG30061

CG42321

(Harbison et al., 2019, Al-Ramahi et al., 2018, Sapar et al., 2018, Aradska et al., 2015, Gene Disruption Project members, 2015-, Vichas et al., 2015, Ma et al., 2012, Abruzzi et al., 2011, Perkins et al., 2009, FlyBase Genome Annotators, 2008)

DmCG42321

(Tanaka et al., 2011)

anon-WO0153538.54

Name Synonyms

ATPase 8A

CG17034

CG30061

Secondary FlyBase IDs

FBgn0033837
FBgn0045898
FBgn0050061

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections