FB2020_06, released Dec 22, 2020

Gene: Dmel\C3G

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General Information
Symbol
Dmel\C3G
Species
D. melanogaster
Name
C3G guanyl-nucleotide exchange factor
Annotation Symbol
CG42328
Feature Type
protein_coding_gene
FlyBase ID
FBgn0259228
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
C3G guanyl-nucleotide exchange factor (C3G) is expressed in the developing embryonic muscles and its product plays a role in body wall muscle development during larval stages. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

DC3G

Key Links
Genomic Location
Cytogenetic map
6D1-6D2
Sequence location
X:6,780,790..6,803,593 [-]
Recombination map

1-18

RefSeq locus
NC_004354 REGION:6780790..6803593
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables guanyl-nucleotide exchange factor activity
inferred from direct assay
(Shirinian et al., 2010)
inferred from mutant phenotype
(assigned by UniProt )
(Ishimaru et al., 1999)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in muscle attachment
inferred from mutant phenotype
(Shirinian et al., 2010)
involved_in positive regulation of GTPase activity
inferred from direct assay
(Shirinian et al., 2010)
involved_in positive regulation of smoothened signaling pathway
inferred from direct assay
(Marada et al., 2016)
involved_in Ras protein signal transduction
inferred from mutant phenotype
(assigned by UniProt )
(Ishimaru et al., 1999)
involved_in regulation of GTPase activity
inferred from direct assay
(Shirinian et al., 2010)
involved_in sarcomere organization
inferred from mutant phenotype
(Shirinian et al., 2010)
involved_in somatic muscle development
inferred from mutant phenotype
(Shirinian et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in intracellular anatomical structure
inferred from electronic annotation with InterPro:IPR008937
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS -
RasGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Ras family GTPases. The RasGEFs are characterized by a CDC25 homology domain. (Adapted from FBrf0220530).
Pathway (FlyBase)
Positive Regulators of Hedgehog Signaling Pathway -
Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
Protein Function (UniProtKB)
Guanine nucleotide-releasing protein that binds to SH3 domain of Crk. Transduces signals from Crk to activate RAS. Also involved in MAPK activation.
(UniProt, O77086)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
9

Please see the JBrowse view of Dmel\C3G for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
C3G-RC
FBtr0299791
NM_176694
7553
1520
C3G-RD
FBtr0299792
NM_001144694
5397
1285
C3G-RE
FBtr0299793
NM_001144695
5651
1417
C3G-RF
FBtr0299794
NM_001144696
5804
1468
C3G-RG
FBtr0299795
NM_001144697
5244
1234
C3G-RH
FBtr0300526
NM_132122
6467
1571
C3G-RI
FBtr0334967
NM_001272362
5648
1414
C3G-RJ
FBtr0334968
NM_001272363
5027
1234
C3G-RK
FBtr0334969
NM_001272364
5804
1468
C3G-RL
FBtr0340087
NM_001298037
6103
1357
Additional Transcript Data and Comments
Reported size (kB)

7.0 (northern blot)

(Ishimaru et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
C3G-PC
FBpp0289069
167.5
1520
7.24
NP_788867
AAO41635
C3G-PD
FBpp0289070
141.1
1285
6.41
NP_001138166
ACL82898
C3G-PE
FBpp0289071
154.6
1417
7.09
NP_001138167
ACL82899
C3G-PF
FBpp0289072
159.2
1468
6.91
NP_001138168
ACL82900
C3G-PG
FBpp0289073
136.5
1234
6.55
NP_001138169
ACL82901
C3G-PH
FBpp0289753
172.1
1571
7.09
NP_572350
AAF46200
C3G-PI
FBpp0306980
153.7
1414
6.78
NP_001259291
AGB95136
C3G-PJ
FBpp0306981
136.5
1234
6.55
NP_001259292
AGB95137
C3G-PK
FBpp0306982
160.7
1468
7.57
NP_001259293
AGB95138
C3G-PL
FBpp0309086
148.5
1357
6.89
NP_001284966
AHN59437
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1234 aa isoforms: C3G-PG, C3G-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)

1383 (aa); 151 (kD predicted)

(Ishimaru et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\C3G using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14
embryonic/larval hindgut

Comment: late embryonic stage 14

(Ishimaru et al., 1999)
embryonic/larval foregut

Comment: late embryonic stage 14

(Ishimaru et al., 1999)
organism | segmentally repeated

Comment: late stage 14

(Ishimaru et al., 1999)
embryonic stage 4 -- 17
(Ishimaru et al., 1999)
embryonic stage 11
visceral mesoderm
(Ishimaru et al., 1999)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage
organism | ubiquitous
(Shirinian et al., 2010)
visceral mesoderm
(Shirinian et al., 2010)
somatic mesoderm
(Shirinian et al., 2010)
embryonic/larval central nervous system
(Shirinian et al., 2010)
embryonic/larval somatic muscle
(Shirinian et al., 2010)
Additional Descriptive Data

C3G is expressed ubiquitously in embryos with stronger expression in the founder cells of the developing visceral mesoderm. It is also observed in the visceral mesoderm at later stages, in somatic muscle and in the CNS.

(Shirinian et al., 2010)

C3G transcript expression is detected starting at embryonic stage 4, with low levels throughout the embryo, and high levels at the anterior and posterior poles. A moderate level of expression is detected in all tissues throughout embryonic development, with higher levels of expression in some tissues. At stage 11, levels are high in the visceral mesoderm. At late stage 14, a segmentally repeated pattern of expression becomes apparent. Expression is also detected in the hindgut and foregut.

(Ishimaru et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\C3G in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of C3G
Transgenic constructs containing regulatory region of C3G
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4Mef2.PR
partially lethal - majority die
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
eclosion defective
increased cell number | adult stage, with Scer\GAL4GMR.PF
short lived
size defective | adult stage, with Scer\GAL4GMR.PF
some die during embryonic stage | heat sensitive, with Scer\GAL4Mef2.PR
some die during larval stage
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
anterior crossvein, with Scer\GAL4dpp.blk1
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
embryonic/larval somatic muscle
embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4GMR.PF
lens, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PF
pigment cell, with Scer\GAL4GMR.PF
rhabdomere, with Scer\GAL4GMR.PF
ventral longitudinal muscle
ventral longitudinal muscle, with Scer\GAL4Mef2.PR
wing disc, with Scer\GAL4dpp.blk1
wing vein L3, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAPGEF1
11 of 15
Yes
Yes
Hsap\RASGRF1
2 of 15
No
Yes
Hsap\RASGRF2
2 of 15
No
Yes
Hsap\SOS1
2 of 15
No
No
Hsap\SOS2
2 of 15
No
No
1  
Hsap\RALGPS1
1 of 15
No
No
Hsap\RALGPS2
1 of 15
No
No
Hsap\RAPGEF2
1 of 15
No
No
2  
Hsap\RASGEF1B
1 of 15
No
No
Hsap\RASGRP1
1 of 15
No
No
Hsap\RASGRP2
1 of 15
No
No
Hsap\RASGRP3
1 of 15
No
No
Hsap\RASGRP4
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rapgef1
11 of 15
Yes
Yes
Mmus\Rasgrf1
2 of 15
No
Yes
Mmus\Rasgrf2
2 of 15
No
Yes
Mmus\Sos1
2 of 15
No
No
Mmus\Sos2
2 of 15
No
No
Mmus\Ralgps1
1 of 15
No
No
Mmus\Ralgps2
1 of 15
No
No
Mmus\Rapgef2
1 of 15
No
No
Mmus\Rapgef6
1 of 15
No
No
Mmus\Rasgef1b
1 of 15
No
No
Mmus\Rasgrp1
1 of 15
No
No
Mmus\Rasgrp2
1 of 15
No
No
Mmus\Rasgrp3
1 of 15
No
No
Mmus\Rasgrp4
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
Rnor\Rapgef1
7 of 13
Yes
Yes
Rnor\Ralgps1
1 of 13
No
No
Rnor\Ralgps2
1 of 13
No
No
Rnor\Rasgrp1
1 of 13
No
No
Rnor\Rasgrp2
1 of 13
No
No
Rnor\Rasgrp3
1 of 13
No
No
Rnor\Rasgrp4
1 of 13
No
No
Rnor\Sos1
1 of 13
No
No
Rnor\Sos2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\rapgef1
6 of 12
Yes
Yes
Xtro\ralgps1
1 of 12
No
No
Xtro\ralgps2
1 of 12
No
No
Xtro\rasgrf1
1 of 12
No
No
Xtro\rasgrf2
1 of 12
No
No
Xtro\rasgrp1
1 of 12
No
No
Xtro\rasgrp3
1 of 12
No
No
Xtro\sos1
1 of 12
No
No
Xtro\sos2
1 of 12
No
No
Danio rerio (Zebrafish) (12)
Drer\rapgef1b
10 of 15
Yes
Yes
Drer\rapgef1a
8 of 15
No
Yes
Drer\rasgrf2b
2 of 15
No
Yes
Drer\si:ch211-234p18.3
2 of 15
No
Yes
Drer\sos1
2 of 15
No
No
Drer\LOC797658
1 of 15
No
No
Drer\plce1
1 of 15
No
Yes
Drer\ralgps1
1 of 15
No
No
Drer\rasgrf2a
1 of 15
No
No
Drer\rasgrp2
1 of 15
No
No
Drer\rasgrp4
1 of 15
No
No
Drer\sos2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\Y34B4A.4
9 of 15
Yes
Yes
Cele\sos-1
2 of 15
No
No
Cele\pxf-1
1 of 15
No
No
Cele\rgef-1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\CDC25
4 of 15
Yes
No
Scer\LTE1
2 of 15
No
No
Scer\BUD5
1 of 15
No
No
Scer\YCL068C
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ste6
2 of 12
Yes
No
Spom\efc25
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901F5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005260
Drosophila simulans
Dsim\GD16179
Drosophila sechellia
Dsec\GM12552
Drosophila erecta
Dere\GG17655
Drosophila yakuba
Dyak\C3G
Drosophila ananassae
Dana\GF20837
Drosophila pseudoobscura pseudoobscura
Dpse\GA16131
Drosophila persimilis
Dper\GL26876
Drosophila willistoni
Dwil\GK25837
Drosophila virilis
Dvir\GJ16545
Drosophila mojavensis
Dmoj\GI21607
Drosophila grimshawi
Dgri\GH24527
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500N8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006979
Musca domestica
House fly
Mdoa\17005400
Musca domestica
House fly
Mdoa\17015900
Glossina morsitans
Tsetse fly
Gmor\GMOY007326
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14481
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013817
Anopheles darlingi
American malaria mosquito
Adar\ADAC003939
Anopheles gambiae
Malaria mosquito
Agam\AGAP000932
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019106
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02GC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS204405-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015678
Apis florea
Little honeybee
Aflo\2904620948
Apis mellifera
Western honey bee
Amel\GB49150
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25894
Bombus terrestris
Buff-tailed bumblebee
Bter\15201617
Bombus terrestris
Buff-tailed bumblebee
Bter\15201623
Bombus terrestris
Buff-tailed bumblebee
Bter\15214328
Linepithema humile
Argentine ant
Lhum\LH21652
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002867
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009786
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01601
Tribolium castaneum
Red flour beetle
Tcas\TC004461
Pediculus humanus
Human body louse
Phum\PHUM211010
Rhodnius prolixus
Kissing bug
Rpro\RPRC008080
Cimex lectularius
Bed bug
Clec\CLEC007753
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008701
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08389
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02DW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009676
Ixodes scapularis
Black-legged tick
Isca\ISCW013763
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63473.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63474.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g01450
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g01430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_229485
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03MV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rapgef1
Ciona intestinalis
Vase tunicate
Cint\LOC100177942
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001832
Gallus gallus
Domestic chicken
Ggal\RAPGEF1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Sos
4 of 10
CG5522
3 of 10
PDZ-GEF
3 of 10
CG4853
2 of 10
CG7369
2 of 10
Epac
2 of 10
Rgl
2 of 10
CG34393
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAPGEF1; Rap guanine nucleotide exchange factor 1
    11 of 15
    600303
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        C3G - drk
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        C3G
        suppressible
        ksr
        (Ishimaru et al., 1999)
        C3G
        suppressible
        Rap1
        (Ishimaru et al., 1999)
        C3G
        suppressible
        Ras85D
        (Ishimaru et al., 1999)
        C3G
        suppressible
        rl
        (Ishimaru et al., 1999)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Cdc42
        enhanceable
        C3G
        (Raymond et al., 2004)
        Nsf2
        suppressible
        C3G
        (Laviolette et al., 2005)
        Rac1
        enhanceable
        C3G
        (Raymond et al., 2004)
        RacGAP84C
        enhanceable
        C3G
        (Raymond et al., 2004)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Positive Regulators of Hedgehog Signaling Pathway -
        Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-18

        Cytogenetic map
        6D1-6D2
        Sequence location
        X:6,780,790..6,803,593 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        6D1-6D2
        Limits computationally determined from genome sequence between P{EP}Ctr1AEP1364&P{EP}EP1445 and P{EP}C3GEP1613; Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        6C7-6D2
        (Ishimaru et al., 1999)
        Experimentally Determined Recombination Data
        Location

        1-18

        (FlyBase, 2016)

        1-18.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (86)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Shirinian et al., 2010)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: C3G CG14436

          (FlyBase Genome Annotators, 2008)
          Additional comments

          Annotations CG3126 and CG14436 merged as CG42328 in release 5.9 of the genome annotation.

          (FlyBase Genome Annotators, 2008)
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Overactivation of C3G during development results in cell fate changes and overproliferation, mimicking overactivity of the RAS-MAPK pathway.

          (Ishimaru et al., 1999)
          Origin and Etymology
          Discoverer
          Etymology

          Named "C3G" after the human ortholog.

          (FlyBase, 2009-)
          Identification
          External Crossreferences and Linkouts ( 82 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (10)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (60)