FlyBase Gene Report: Dmel\CG42329

OTHER NON-AMINO-ACYL ACYL GROUP TRANSFERASES -: Other acyl groups other than amino-acyl group transferases is a collection of transferases that do not fit into any of the other major acyl groups other than amino-acyl group transferases.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG42329 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPZ4)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq data). May be specific to sequenced strain; not included in gene model.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG42329-RA

FBtr0299796

NM_134746

2477

691

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG42329-PA

FBpp0289074

77.1

691

7.81

NP_608590

AAF51390

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VPZ4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG42329 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42329_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT21-0

(Xu et al., 2011)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG42329 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG42329

View exonic expression by tissue for Dmel\CG42329

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259229

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33312/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259229

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259229

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259229

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5156

Flygut - An atlas of the Drosophila adult midgut

FBgn0259229

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG42329

Transgenic constructs containing regulatory region of CG42329

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel7006

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG42329^c05647

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG42329^GD801

viable, with Scer\GAL4^Mef2.PR

CG42329^GD801

viable, with Scer\GAL4^pnr-MD237

CG42329^GD801

viable, with Scer\GAL4^tin.CΔ4

CG42329^GD801

Sterility

Allele

fertile

CG42329^c05647

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LOC112268211

2 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Oacyl

11 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Oacyl

10 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\LOC101732251

3 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\oacyl

7 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (40)

Cele\oac-3

10 of 15

Yes

Cele\oac-5

10 of 15

Yes

Cele\oac-6

10 of 15

Yes

Cele\oac-7

10 of 15

Yes

Cele\oac-14

10 of 15

Yes

Cele\oac-20

10 of 15

Yes

Cele\oac-31

10 of 15

Yes

Cele\oac-32

10 of 15

Yes

Cele\oac-53

9 of 15

Yes

Cele\nrf-6

7 of 15

Cele\oac-55

7 of 15

Yes

Cele\oac-50

6 of 15

Yes

Cele\ndg-4

5 of 15

Yes

Cele\oac-39

5 of 15

Yes

Cele\oac-46

5 of 15

Yes

Cele\oac-9

4 of 15

Yes

Cele\oac-54

4 of 15

Cele\rhy-1

4 of 15

Cele\bus-1

1 of 15

Yes

Cele\oac-1

1 of 15

Yes

Cele\oac-2

1 of 15

Yes

Cele\oac-8

1 of 15

Yes

Cele\oac-10

1 of 15

Yes

Cele\oac-12

1 of 15

Yes

Cele\oac-15

1 of 15

Yes

Cele\oac-18

1 of 15

Yes

Cele\oac-24

1 of 15

Yes

Cele\oac-26

1 of 15

Yes

Cele\oac-27

1 of 15

Yes

Cele\oac-29

1 of 15

Yes

Cele\oac-30

1 of 15

Yes

Cele\oac-33

1 of 15

Yes

Cele\oac-36

1 of 15

Yes

Cele\oac-37

1 of 15

Yes

Cele\oac-40

1 of 15

Yes

Cele\oac-41

1 of 15

Yes

Cele\oac-43

1 of 15

Yes

Cele\oac-44

1 of 15

Yes

Cele\oac-45

1 of 15

Yes

Cele\oac-56

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

8 of 10

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

drd

4 of 10

CG30467

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59563

DroID - A comprehensive database of gene and protein interactions.

FBgn0259229

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-2

Cytogenetic map

21F2-21F2

Sequence location

2L:1,219,293..1,229,802 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21F2-21F2

Limits computationally determined from genome sequence between P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619 and P{lacW}RFeSP^k11704

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-2

(FlyBase, 2016)

2-2.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17718

w¹¹¹⁸; PBac{PB}CG42329^c05647

43874

y¹ w^*; Mi{MIC}CG42329^MI05441

VDRC

v101613

P{KK105201}VIE-260B

v110085

P{KK106448}VIE-260B

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (92)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD06908

Other clones

IP06484

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259229

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259229

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33312

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG14343 CG5156

(FlyBase Genome Annotators, 2008)

Additional comments

Annotations CG14343 and CG5156 merged as CG42329 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Identified as one of 10 highest fold cycling genes as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33312

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF51390

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPZ4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VPZ4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPZ4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259229

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259229

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33312/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259229

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42329_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259229

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259229

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5156

Flygut - An atlas of the Drosophila adult midgut

FBgn0259229

FlyMine - An integrated database for Drosophila genomics

FBgn0259229

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33312

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42329

MARRVEL_MODEL - MARRVEL (model organism gene)

33312

modMine - A data warehouse for the modENCODE project

FBgn0259229

Linkouts

BioGRID - A database of protein and genetic interactions.

59563

DroID - A comprehensive database of gene and protein interactions.

FBgn0259229

DRSC - Results frm RNAi screens

FBgn0259229

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259229

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG14343

(Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5, Blumenthal, 2008, Spellman and Rubin, 2002)

CG42329

(Ando et al., 2019, Palu and Thummel, 2016, Steele et al., 2015, Kwon et al., 2013, FlyBase Genome Annotators, 2008)

CG5156

(Japanese National Institute of Genetics, 2012.5.21, Xu et al., 2011, Keleman et al., 2009.8.5, Blumenthal, 2008, Spellman and Rubin, 2002)

CT16503

(Ceriani et al., 2002)

Name Synonyms

CG14343

CG5156

Secondary FlyBase IDs

FBgn0031325
FBgn0031326

Datasets (1)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (1)

Result

Result Type

Title

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections